{"id":3698,"date":"2014-08-11T09:00:28","date_gmt":"2014-08-11T01:00:28","guid":{"rendered":"http:\/\/localhost:9966\/?p=3698"},"modified":"2026-06-23T15:47:03","modified_gmt":"2026-06-23T07:47:03","slug":"%e8%8d%af%e5%93%81%e4%b8%8d%e8%89%af%e5%8f%8d%e5%ba%94%e4%bf%a1%e6%81%af%e9%80%9a%e6%8a%a5%ef%bc%88%e7%ac%ac62%e6%9c%9f%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.blpa.com.cn\/?p=3698","title":{"rendered":"\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u4fe1\u606f\u901a\u62a5\uff08\u7b2c62\u671f\uff09"},"content":{"rendered":"

\n\t\u9650\u5236\u66f2\u7f8e\u4ed6\u55ea\u9002\u5e94\u75c7\u5e76\u8b66\u60d5\u5176\u5f15\u8d77\u7684\u8fd0\u52a8\u969c\u788d\u7b49<\/span><\/span><\/span>\n<\/p>\n

\n\t\u5b89\u5168\u6027\u98ce\u9669<\/span><\/span><\/span>\n<\/p>\n

\n\t\u53d1\u5e03\u65e5\u671f\uff1a<\/span>2014-08-04<\/span><\/span><\/b>\n<\/p>\n

\n\t<\/span><\/b>\n<\/p>\n

\n\t\u7f16\u8005\u6309\uff1a<\/span><\/span><\/b>
\n<\/span><\/b>  \u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u4fe1\u606f\u901a\u62a5\u5236\u5ea6\u662f\u6211\u56fd\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u90e8\u95e8\u4e3a\u4fdd\u969c\u516c\u4f17\u7528\u836f\u5b89\u5168\u800c\u5efa\u7acb\u7684\u4e00\u9879\u5236\u5ea6\u3002\u300a\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u4fe1\u606f\u901a\u62a5\u300b\u9762\u5411\u793e\u4f1a\u516c\u5f00\u53d1\u5e03\uff0c\u5bf9\u63a8\u52a8\u6211\u56fd\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u5de5\u4f5c\uff0c\u4fdd\u969c\u5e7f\u5927\u4eba\u6c11\u7fa4\u4f17\u7528\u836f\u5b89\u5168\u8d77\u5230\u4e86\u79ef\u6781\u7684\u4f5c\u7528\u3002<\/span><\/span>
\n<\/span>  \u300a\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u4fe1\u606f\u901a\u62a5\u300b\u56fd\u5916\u4fe1\u606f\u7248\u4e3b\u8981\u4ecb\u7ecd\u6709\u5173\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u90e8\u95e8\u53d1\u5e03\u7684\u6700\u65b0\u5b89\u5168\u6027\u4fe1\u606f\uff0c\u5206\u6790\u5b89\u5168\u6027\u4fe1\u606f\u53d1\u5e03\u7684\u80cc\u666f\u53ca\u76f8\u5173\u6280\u672f\u8d44\u6599\uff0c\u540c\u65f6\u53c2\u8003\u901a\u62a5\u54c1\u79cd\u5728\u6211\u56fd\u4e34\u5e8a\u4f7f\u7528\u60c5\u51b5\uff0c\u8bc4\u4f30\u5176\u5728\u6211\u56fd\u7684\u5b89\u5168\u6027\u3002\u53d1\u5e03\u300a\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u4fe1\u606f\u901a\u62a5\u300b\u56fd\u5916\u4fe1\u606f\u7248\u65e8\u5728\u8ba9\u5e7f\u5927\u4eba\u6c11\u7fa4\u4f17\uff0c\u5c24\u5176\u662f\u533b\u52a1\u5de5\u4f5c\u8005\uff0c\u5168\u9762\u4e86\u89e3\u548c\u638c\u63e1\u6700\u65b0\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u4fe1\u606f\uff0c\u964d\u4f4e\u6216\u907f\u514d\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u7684\u91cd\u590d\u53d1\u751f<\/span> <\/span>
\n<\/span>  \u672c\u671f\u901a\u62a5\u7684\u54c1\u79cd\u662f\u66f2\u7f8e\u4ed6\u55ea\uff0c\u5c5e\u4e8e\u5fc3\u8840\u7ba1\u7cfb\u7edf\u836f\u7269\u3002\u6839\u636e\u56fd\u5bb6\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u6570\u636e\u4fe1\u606f\u8bc4\u4ef7\u60c5\u51b5\uff0c\u7ed3\u5408\u6b27\u76df\u836f\u54c1\u7ba1\u7406\u5c40\u53d1\u5e03\u7684\u76d1\u7ba1\u63aa\u65bd\uff0c\u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u603b\u5c40\u5efa\u8bae\u66f2\u7f8e\u4ed6\u55ea\u4ec5\u7528\u4e8e\u5bf9\u4e00\u7ebf\u6297\u5fc3\u7ede\u75db\u7597\u6cd5\u63a7\u5236\u4e0d\u4f73\u6216\u65e0\u6cd5\u8010\u53d7\u7684\u7a33\u5b9a\u578b\u5fc3\u7ede\u75db\u60a3\u8005\u7684\u5bf9\u75c7\u6cbb\u7597\uff0c\u4e0d\u518d\u7528\u4e8e\u8033\u9e23\u3001\u7729\u6655\u7684\u6cbb\u7597\uff1b\u5e15\u91d1\u68ee\u75c5\u7b49\u8fd0\u52a8\u969c\u788d\u7981\u7528\u548c\u4e25\u91cd\u80be\u529f\u80fd\u635f\u5bb3\u60a3\u8005\u7981\u7528\u3002\u4e3a\u4f7f\u5e7f\u5927\u533b\u52a1\u4eba\u5458\u548c\u60a3\u8005\u4e86\u89e3\u8be5\u836f\u54c1\u7684\u4f7f\u7528\u98ce\u9669\uff0c\u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u603b\u5c40\u7279\u53d1\u5e03\u6b64\u671f\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u4fe1\u606f\u901a\u62a5\u3002<\/span><\/span><\/span>\n<\/p>\n

\n\t\u9650\u5236\u66f2\u7f8e\u4ed6\u55ea\u9002\u5e94\u75c7\u5e76\u8b66\u60d5\u5176\u5f15\u8d77\u7684\u8fd0\u52a8\u969c\u788d\u7b49\u5b89\u5168\u6027\u98ce\u9669<\/span><\/span><\/b><\/span>\n<\/p>\n

\n\t  \u66f2\u7f8e\u4ed6\u55ea\u5c5e\u4e8e\u5fc3\u8840\u7ba1\u7cfb\u7edf\u836f\u7269\u3002\u6839\u636e\u56fd\u5bb6\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u6570\u636e\u4fe1\u606f\u8bc4\u4ef7\u60c5\u51b5\uff0c\u7ed3\u5408\u6b27\u76df\u836f\u54c1\u7ba1\u7406\u5c40\u53d1\u5e03\u7684\u76d1\u7ba1\u63aa\u65bd\uff0c\u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u603b\u5c40\u5efa\u8bae\u66f2\u7f8e\u4ed6\u55ea\u4ec5\u7528\u4e8e\u5bf9\u4e00\u7ebf\u6297\u5fc3\u7ede\u75db\u7597\u6cd5\u63a7\u5236\u4e0d\u4f73\u6216\u65e0\u6cd5\u8010\u53d7\u7684\u7a33\u5b9a\u578b\u5fc3\u7ede\u75db\u60a3\u8005\u7684\u5bf9\u75c7\u6cbb\u7597\uff0c\u4e0d\u518d\u7528\u4e8e\u8033\u9e23\u3001\u7729\u6655\u7684\u6cbb\u7597\uff1b\u5e15\u91d1\u68ee\u75c5\u7b49\u8fd0\u52a8\u969c\u788d\u7981\u7528\u548c\u4e25\u91cd\u80be\u529f\u80fd\u635f\u5bb3\u60a3\u8005\u7981\u7528\u3002\u4e3a\u4f7f\u5e7f\u5927\u533b\u52a1\u4eba\u5458\u548c\u60a3\u8005\u4e86\u89e3\u8be5\u836f\u54c1\u7684\u4f7f\u7528\u98ce\u9669\uff0c\u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u603b\u5c40\u7279\u5bf9\u66f2\u7f8e\u4ed6\u55ea\u7684\u5b89\u5168\u6027\u95ee\u9898\u8fdb\u884c\u901a\u62a5\u3002<\/span><\/span><\/span>\n<\/p>\n

\n\t  <\/span><\/span>\u4e00\u3001\u4ea7\u54c1\u57fa\u672c\u60c5\u51b5<\/span><\/span><\/b>
\n<\/span><\/b>  \u66f2\u7f8e\u4ed6\u55ea\u4f5c\u4e3a\u6297\u5fc3\u7ede\u75db\u836f\u7269\uff0c\u5177\u6709\u5bf9\u6297\u80be\u4e0a\u817a\u7d20\u3001\u53bb\u7532\u80be\u4e0a\u817a\u7d20\u53ca\u52a0\u538b\u7d20\u7684\u4f5c\u7528\uff0c\u80fd\u964d\u4f4e\u8840\u7ba1\u963b\u529b\uff0c\u589e\u52a0\u51a0\u8109\u53ca\u5faa\u73af\u8840\u6d41\u91cf\uff0c\u4fc3\u8fdb\u5fc3\u808c\u4ee3\u8c22\u53ca\u5fc3\u808c\u80fd\u91cf\u7684\u4ea7\u751f\uff0c\u540c\u65f6\u80fd\u964d\u4f4e\u5fc3\u808c\u8017\u6c27\u91cf\uff0c\u4ece\u800c\u6539\u5584\u5fc3\u808c\u6c27\u7684\u4f9b\u9700\u5e73\u8861\u3002\u9002\u5e94\u75c7\u6709\uff08<\/span>1\uff09\u4e34\u5e8a\u7528\u4e8e\u5fc3\u7ede\u75db\u53d1\u4f5c\u7684\u9884\u9632\u6027\u6cbb\u7597\uff1b\uff082\uff09\u7729\u6655\u548c\u8033\u9e23\u7684\u8f85\u52a9\u6027\u5bf9\u75c7\u6cbb\u7597\u3002\u56fd\u5916\u9002\u5e94\u75c7\u8fd8\u5305\u62ec\u8840\u7ba1\u539f\u56e0\u5bfc\u81f4\u7684\u89c6\u529b\u4e0b\u964d\u548c\u89c6\u91ce\u969c\u788d\u7684\u8f85\u52a9\u6027\u6cbb\u7597\u3002<\/span>
\n<\/span>  <\/span>1978\u5e74\uff0c\u6cd5\u56fd\u65bd\u7ef4\u96c5\u836f\u5382\u7814\u5236\u7684\u66f2\u7f8e\u4ed6\u55ea\u5728\u6cd5\u56fd\u83b7\u5f97\u4e0a\u5e02\u8bb8\u53ef\uff0c\u76ee\u524d\u66f2\u7f8e\u4ed6\u55ea\u5728\u5168\u740390\u591a\u4e2a\u56fd\u5bb6\u4e0a\u5e02\u30022000\u5e74\uff0c\u66f2\u7f8e\u4ed6\u55ea\u5728\u6211\u56fd\u4e0a\u5e02\uff0c\u76ee\u524d\u6709\u7247\u5242\uff0820 mg\uff09\u548c\u7f13\u91ca\u7247\u5242\uff0835 mg\uff09\u4e24\u79cd\u5242\u578b\uff0c\u6d89\u53ca\u751f\u4ea7\u4f01\u4e1a11\u5bb6\u3002<\/span><\/span>\n<\/p>\n

\n\t  <\/span><\/span>\u4e8c\u3001\u6b27\u76df\u5bf9\u66f2\u7f8e\u4ed6\u55ea\u7684\u98ce\u9669\u8bc4\u4f30\u4ee5\u53ca\u91c7\u53d6\u7684\u76d1\u7ba1\u63aa\u65bd<\/span><\/span><\/b>
\n<\/span><\/b>  <\/span>(\u4e00)\u6709\u6548\u6027\u8bc4\u4f30\u8bc1\u636e<\/span>
\n<\/span>  \u6b27\u76df\u4e8e<\/span>2011\u5e744\u6708\u542f\u52a8\u4e862001\/83\/EC\u6307\u4ee4\u7b2c31\u6761\u9879\uff0c\u5bf9\u66f2\u7f8e\u4ed6\u55ea\u98ce\u9669\/\u83b7\u76ca\u8fdb\u884c\u518d\u8bc4\u4ef7\uff0c\u76ee\u524d\u5df2\u5b8c\u6210\u4e86\u5bf9\u73b0\u6709\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u6570\u636e\u8bc4\u4ef7\uff0c\u5177\u4f53\u5982\u4e0b\uff1a<\/span>
\n<\/span>  <\/span>1.\u7528\u4e8e\u5fc3\u7ede\u75db\u7684\u6cbb\u7597<\/span>
\n<\/span>  <\/span>CHMP\u8bc4\u4f30\u4e86\u66f2\u7f8e\u4ed6\u55ea\u6cbb\u7597\u5fc3\u7ede\u75db\u7684\u6240\u6709\u7814\u7a76\u9879\u76ee\uff1aTRIMPOL-\u2161\u7814\u7a761\u3001Sellier\u7684\u7814\u7a762\u4ee5\u53ca\u6765\u81eaVASCO\u7814\u7a763\uff0c\u8fd9\u4e9b\u6570\u636e\u90fd\u652f\u6301\u66f2\u7f8e\u4ed6\u55ea\u5728\u6cbb\u7597\u5fc3\u7ede\u75db\u60a3\u8005\u4e2d\u5177\u6709\u7597\u6548\uff0c\u5728\u03b2-\u53d7\u4f53\u963b\u65ad\u5242\u7684\u57fa\u7840\u4e0a\u9644\u52a0\u4f7f\u7528\u66f2\u7f8e\u4ed6\u55ea\u65f6\u4e5f\u5177\u6709\u7597\u6548\u3002\u6b64\u5916\uff0cManchanda\u5c55\u5f00\u7684\u4e24\u9879\u7814\u7a76\u548c\u5176\u4ed6\u56db\u9879\u5c0f\u6837\u672c\u7814\u7a764-5\u7ed3\u679c\u663e\u793a\uff0c\u5728\u9499\u901a\u9053\u963b\u6ede\u5242\uff08CCB\uff09\u7684\u57fa\u7840\u4e0a\u9644\u52a0\u4f7f\u7528\u66f2\u7f8e\u4ed6\u55ea\u65f6\u540c\u6837\u5177\u6709\u7597\u6548\u3002CHMP\u8ba4\u4e3a\u66f2\u7f8e\u4ed6\u55ea\u53ef\u4ee5\u4f5c\u4e3a\u4e00\u79cd\u9644\u52a0\u6cbb\u7597\u836f\u4e0e\u4e00\u7ebf\u6297\u5fc3\u7ede\u75db\u836f\u7269\u8054\u5408\u4f7f\u7528\uff0c\u7279\u522b\u662f\u90a3\u4e9b\u56e0\u4e3a\u8840\u6d41\u52a8\u529b\u5b66\u4e0d\u8010\u53d7\u6027\u6216\u5fc3\u7387\u53d8\u65f6\u6027\u529f\u80fd\u4e0d\u5168\u800c\u65e0\u6cd5\u4f7f\u7528\u5176\u4ed6\u6297\u5fc3\u7ede\u75db\u836f\u7269\u5355\u72ec\u6cbb\u7597\u7684\u60a3\u8005\u3002<\/span>
\n<\/span>  <\/span>2.\u7528\u4e8e\u8033\u3001\u9f3b\u3001\u5589\u79d1\u7684\u6cbb\u7597<\/span>
\n<\/span>  <\/span>CHMP\u8bc4\u4f30\u4e86\u66f2\u7f8e\u4ed6\u55ea\u5728\u8033\u9f3b\u5589\u79d1\u9002\u5e94\u75c7\u65b9\u9762\u7684\u4e5d\u9879\u4e34\u5e8a\u7814\u7a76\uff08Wayoff\uff0c1984\u5e746\uff1bSterkers\uff0c2001\u5e74\uff1bVitte\uff0c2002\u5e747\uff1bHaguenauer\uff0c1980\u5e748\uff1bKluyskens\uff0c1990\u5e749\uff1bMartini\uff0c1990\u5e7410\uff1bMorgon\uff0c1990\u5e7411\uff1bCoyas\uff0c1990\u5e7412\uff1b\u6cd5\u56fd\u8033\u8717\u7814\u7a76\uff09\uff0c\u7eb3\u5165\u8fd9\u4e9b\u7814\u7a76\u7684\u5927\u90e8\u5206\u60a3\u8005\u90fd\u5b58\u5728\u591a\u79cd\u4e25\u91cd\u7a0b\u5ea6\u4e0d\u540c\u7684\u75be\u75c5\uff0c\u4e14\u672a\u5bf9\u8fd9\u4e9b\u75be\u75c5\u8fdb\u884c\u75c5\u7406\u5b66\u5206\u5c42\uff0c\u6cbb\u7597\u65f6\u95f4\u975e\u5e38\u6709\u9650\uff082\u81f33\u4e2a\u6708\uff09\uff0c\u4e0d\u7b26\u5408\u8fd9\u4e9b\u75be\u75c5\u5fc5\u9700\u957f\u671f\u6cbb\u7597\u7684\u8981\u6c42\u3002\u8fd9\u4e9b\u6570\u636e\u65e0\u6cd5\u652f\u6301\u66f2\u7f8e\u4ed6\u55ea\u5bf9\u60a3\u6709\u8033\u9e23\u3001\u7729\u6655\u6216\u542c\u529b\u4e0b\u964d\u75c7\u72b6\u7684\u60a3\u8005\u7684\u4e34\u5e8a\u6cbb\u7597\u4e2d\u83b7\u76ca\u3002CHMP\u8ba4\u4e3a\u5e94\u8be5\u5220\u9664\u66f2\u7f8e\u4ed6\u55ea\u5728\u8033\u9f3b\u5589\u79d1\u65b9\u9762\u7684\u9002\u5e94\u75c7\u3002<\/span>
\n<\/span>  <\/span>3.\u7528\u4e8e\u773c\u79d1\u7684\u6cbb\u7597<\/span>
\n<\/span>  <\/span>CHMP\u8bc4\u4f30\u4e86\u66f2\u7f8e\u4ed6\u55ea\u5728\u773c\u79d1\u9002\u5e94\u75c7\u65b9\u9762\u7684\u4e5d\u9879\u4e34\u5e8a\u7814\u7a76\uff08Guillaumat\uff0c1982\u5e7413\uff1bMillara\uff0c1988\u5e7414\uff1bNowak\uff0c2007\u5e7415\uff1bCouderc\uff0c1984\u5e74\uff1bAron-Rosa\uff0c1988\u5e74\uff1b\u6cd5\u56fdARMD 2\uff0c2008\u5e74\uff1bCornand\uff0c1982\u5e7416\uff1bCordella,1982\u5e7417\uff1bPerdriel\uff0c1988\u5e7418\uff09\uff0c\u5176\u4e2d\u516b\u9879\u7814\u7a76\u7eb3\u5165\u7684\u60a3\u8005\u5b58\u5728\u591a\u79cd\u590d\u6742\u7684\u4e25\u91cd\u7a0b\u5ea6\u4e0d\u540c\u7684\u75be\u75c5\uff0c\u4e14\u672a\u5bf9\u8fd9\u4e9b\u75be\u75c5\u8fdb\u884c\u75c5\u7406\u5b66\u5206\u5c42\uff0c\u6cbb\u7597\u65f6\u95f4\u77ed\uff082\u81f36\u4e2a\u6708\u4e4b\u95f4\uff09\uff0c\u4e0d\u7b26\u5408\u8fd9\u4e9b\u75be\u75c5\u9700\u8981\u957f\u671f\u6cbb\u7597\u7684\u8981\u6c42\u3002CHMP\u8ba4\u4e3a\u8fd9\u4e9b\u6570\u636e\u4e0d\u8db3\u4ee5\u652f\u6301\u66f2\u7f8e\u4ed6\u55ea\u5728\u8f85\u52a9\u6cbb\u7597\u8840\u7ba1\u539f\u56e0\u6240\u81f4\u7684\u89c6\u529b\u4e0b\u964d\u548c\u89c6\u91ce\u969c\u788d\u65b9\u9762\u7684\u4e34\u5e8a\u6709\u6548\u6027\uff0c\u5efa\u8bae\u5220\u9664\u3002<\/span>
\n<\/span>  <\/span>(\u4e8c)\u5b89\u5168\u6027\u7684\u8bc4\u4f30\u8bc1\u636e<\/span>
\n<\/span>  \u6b64\u5916\uff0c\u6b27\u76df\u8fd8\u5bf9\u66f2\u7f8e\u4ed6\u55ea\u7684\u5b89\u5168\u6027\u8fdb\u884c\u4e86\u8bc4\u4f30\uff0c\u7ed3\u679c\u5982\u4e0b\uff1a<\/span><\/span>
\n<\/span>  <\/span>CHMP\u8ba4\u4e3a\u542b\u66f2\u7f8e\u4ed6\u55ea\u7c7b\u836f\u7269\u5e94\u7981\u7528\u4e8e\u5e15\u91d1\u68ee\u7efc\u5408\u5f81\u3001\u9707\u98a4\u3001\u4e0d\u5b89\u817f\u7efc\u5408\u5f81\u4ee5\u53ca\u5176\u4ed6\u76f8\u5173\u8fd0\u52a8\u969c\u788d\u7684\u60a3\u8005\uff0c\u5e76\u5bf9\u8bf4\u660e\u4e66\u8fdb\u884c\u4fee\u6539\uff0c\u6dfb\u52a0\u66f2\u7f8e\u4ed6\u55ea\u53ef\u80fd\u5f15\u8d77\u5e15\u91d1\u68ee\u7efc\u5408\u5f81\u7684\u8b66\u544a\u4e8b\u9879\u3002<\/span>
\n<\/span>  \u5df2\u6709\u7684\u6587\u732e\u4e2d\u62a5\u9053\uff1a\u66f2\u7f8e\u4ed6\u55ea\u64a4\u836f\u4e4b\u540e\uff0c\u5e15\u91d1\u68ee\u75c7\u72b6\u5448\u53bb\u6fc0\u53d1\u9633\u6027\uff08\u64a4\u9664\u66f2\u7f8e\u4ed6\u55ea\u540e\u75c7\u72b6\u51cf\u8f7b\u6216\u6d88\u5931\uff09\u548c\u518d\u6fc0\u53d1\u9633\u6027\uff08\u518d\u6b21\u4f7f\u7528\u66f2\u7f8e\u4ed6\u55ea\u540e\u75c7\u72b6\u518d\u6b21\u51fa\u73b0\uff09\uff1b\u66f2\u7f8e\u4ed6\u55ea\u7ec4\u4e0e\u6297\u5e15\u91d1\u68ee\u6c0f\u75c5\u836f\u7269\u8054\u5408\u4f7f\u7528\u65f6\u4e0d\u826f\u53cd\u5e94\u7387\u660e\u663e\u9ad8\u4e8e\u5bf9\u7167\u7ec4\uff1b\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u670d\u7528\u66f2\u7f8e\u4ed6\u55ea\u4e4b\u540e\uff0c\u5f00\u59cb\u670d\u7528\u6297\u5e15\u91d1\u68ee\u6c0f\u75c5\u836f\u7269\u7684\u60a3\u8005\u4eba\u6570\u660e\u663e\u589e\u591a\u3002<\/span><\/span>
\n<\/span>  \u8001\u5e74\u60a3\u8005\u53ef\u80fd\u7531\u4e8e\u80be\u529f\u80fd\u964d\u4f4e\u4f7f\u5f97\u66f2\u7f8e\u4ed6\u55ea\u66b4\u9732\u91cf\u589e\u52a0\uff0c\u5177\u6709\u8f83\u9ad8\u66f2\u7f8e\u4ed6\u55ea\u8840\u6d46\u836f\u7269\u6d53\u5ea6\uff0c\u53d1\u751f\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u7684\u9891\u7387\u66f4\u9ad8\uff08<\/span>Emeriau PK\u7814\u7a76\uff09\uff0cCHMP\u8ba4\u4e3a\u542b\u66f2\u7f8e\u4ed6\u55ea\u7c7b\u836f\u54c1\u5e94\u7981\u7528\u4e8e\u4e25\u91cd\u80be\u529f\u80fd\u4e0d\u5168\u60a3\u8005\uff08\u808c\u9150\u6e05\u9664\u7387<30 ml\/min\uff09\uff0c\u5bf9\u4e8e\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u5bb3\uff08\u808c\u9150\u6e05\u9664\u7387\u301030-60\u3011ml\/min\uff09\u7684\u60a3\u8005\u5e94\u964d\u4f4e\u65e5\u5242\u91cf\u3002\u6b64\u5916\u98ce\u9669\u7ba1\u7406\u8ba1\u5212\u8fd8\u7eb3\u5165\u4e86\u65b0\u7684\u3001\u7f55\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3001\u7c92\u7ec6\u80de\u7f3a\u4e4f\u75c7\u548c\u809d\u810f\u75be\u75c5\uff0c\u5e76\u6dfb\u52a0\u5230\u8bf4\u660e\u4e66\u7684\u3010\u4e0d\u826f\u53cd\u5e94\u3011\u4e2d\u3002CHMP\u8fd8\u8981\u6c42\u5f00\u5c55\u4e0a\u5e02\u540e\u5b89\u5168\u6027\u7814\u7a76\uff0c\u76d1\u6d4b\u6240\u6709\u91cd\u8981\u7684\u3001\u6f5c\u5728\u7684\u5df2\u8bc6\u522b\u98ce\u9669\uff0c\u7279\u522b\u662f\u5e15\u91d1\u68ee\u6c0f\u75c5\u3002<\/span>
\n<\/span>  <\/span>(\u4e09)\u91c7\u53d6\u7684\u76d1\u7ba1\u63aa\u65bd<\/span>
\n<\/span>  \u5bf9\u5168\u90e8\u73b0\u6709\u6570\u636e\u8fdb\u884c\u8bc4\u4f30\u540e\uff0c\u6b27\u76df\u836f\u54c1\u7ba1\u7406\u5c40\u53d1\u5e03\u6d88\u606f\uff0c\u5efa\u8bae\u9650\u5236\u66f2\u7f8e\u4ed6\u55ea\u9002\u5e94\u75c7\u7684\u4f7f\u7528\uff0c\u4ec5\u7528\u4e8e\u5bf9\u4e00\u7ebf\u6297\u5fc3\u7ede\u75db\u7597\u6cd5\u63a7\u5236\u4e0d\u4f73\u6216\u65e0\u6cd5\u8010\u53d7\u7684\u7a33\u5b9a\u578b\u5fc3\u7ede\u75db\u60a3\u8005\u7684\u5bf9\u75c7\u6cbb\u7597\u3002\u5bf9\u4e8e\u8be5\u836f\u7684\u5176\u4ed6\u7684\u9002\u5e94\u75c7\uff08\u7729\u6655\u3001\u8033\u9e23\u548c\u89c6\u89c9\u969c\u788d\uff09\uff0c<\/span>CHMP\u8ba4\u4e3a\u4e34\u5e8a\u6709\u6548\u6027\u8bc1\u636e\u4e0d\u8db3\uff0c\u5efa\u8bae\u5220\u9664\u8fd9\u4e9b\u9002\u5e94\u75c7\u3002<\/span>
\n<\/span>  \u6b27\u76df\u8fd8\u5bf9\u4e0e\u66f2\u7f8e\u4ed6\u55ea\u6709\u5173\u7684\u8fd0\u52a8\u969c\u788d\u8fdb\u884c\u4e86\u8bc4\u4f30\uff0c\u5305\u62ec\u5e15\u91d1\u68ee\u7efc\u5408\u5f81\u3001\u4e0d\u5b89\u817f\u3001\u9707\u98a4\u548c\u8d70\u8def\u4e0d\u7a33\u7b49\uff0c<\/span>CHMP\u5efa\u8bae\u5728\u4ea7\u54c1\u8bf4\u660e\u4e66\u4e2d\u589e\u52a0\u65b0\u7684\u7981\u5fcc\u75c7\u548c\u8b66\u544a\u4ee5\u964d\u4f4e\u4f7f\u7528\u8be5\u836f\u53ef\u80fd\u5f15\u8d77\u7684\u8fd0\u52a8\u969c\u788d\u7684\u98ce\u9669\uff0c\u533b\u751f\u4e0d\u5e94\u5c06\u66f2\u7f8e\u4ed6\u55ea\u5904\u65b9\u7ed9\u6709\u5e15\u91d1\u68ee\u6c0f\u75c7\u72b6\u3001\u4e0d\u5b89\u817f\u3001\u9707\u98a4\u548c\u8d70\u8def\u4e0d\u7a33\u7b49\u8fd0\u52a8\u529f\u80fd\u969c\u788d\u7684\u60a3\u8005\u3002\u8001\u5e74\u60a3\u8005\u53ef\u80fd\u7531\u4e8e\u80be\u529f\u80fd\u964d\u4f4e\u4f7f\u5f97\u66f2\u7f8e\u4ed6\u55ea\u66b4\u9732\u91cf\u589e\u52a0\uff0c\u5177\u6709\u8f83\u9ad8\u66f2\u7f8e\u4ed6\u55ea\u8840\u6d46\u836f\u7269\u6d53\u5ea6\uff0c\u53d1\u751f\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u7684\u9891\u7387\u66f4\u9ad8\uff0cCHMP\u8ba4\u4e3a\u542b\u66f2\u7f8e\u4ed6\u55ea\u7c7b\u836f\u54c1\u5e94\u7981\u7528\u4e8e\u4e25\u91cd\u80be\u529f\u80fd\u4e0d\u5168\u60a3\u8005\uff08\u808c\u9150\u6e05\u9664\u7387<30 ml\/min\uff09\uff0c\u5bf9\u4e8e\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u5bb3\uff08\u808c\u9150\u6e05\u9664\u7387\u301030-60\u3011ml\/min\uff09\u7684\u60a3\u8005\u5e94\u964d\u4f4e\u65e5\u5242\u91cf\u3002\u6b64\u5916\uff0cCHMP\u5efa\u8bae\u5728\u8bf4\u660e\u4e66\u4e2d\u7eb3\u5165\u4e86\u65b0\u7684\u3001\u7f55\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3001\u7c92\u7ec6\u80de\u7f3a\u4e4f\u75c7\u548c\u809d\u810f\u75be\u75c5\u3002<\/span><\/span>\n<\/p>\n

\n\t  <\/span><\/span>\u4e09\u3001\u56fd\u5185\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u60c5\u51b5<\/span><\/span><\/b>
\n<\/span><\/b>  <\/span>(\u4e00)\u603b\u4f53\u60c5\u51b5<\/span>
\n<\/span>  \u622a\u81f3<\/span>2013\u5e7412\u670831\u65e5\uff0c\u56fd\u5bb6\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u6570\u636e\u5e93\u4e2d\u5171\u6536\u5230\u66f2\u7f8e\u4ed6\u55ea\u4e0d\u826f\u53cd\u5e94\/\u4e8b\u4ef6\u62a5\u544a1609\u4f8b\uff0c\u5176\u4e2d\u4e25\u91cd\u62a5\u544a21\u4f8b\uff0c\u5360\u62a5\u544a\u603b\u6570\u76841.3%\uff0c\u65e0\u6b7b\u4ea1\u75c5\u4f8b\u3002<\/span>
\n<\/span>  <\/span>(\u4e8c)\u7528\u836f\u539f\u56e0\u5206\u6790<\/span>
\n<\/span>  <\/span>1609\u4f8b\u4e0d\u826f\u53cd\u5e94\/\u4e8b\u4ef6\u62a5\u544a\u4e2d\uff0c\u7528\u4e8e\u6cbb\u7597\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u7684\u67091367\u4f8b\uff0c\u5360\u6240\u6709\u75c5\u4f8b\u62a5\u544a\u768484.9%\uff0c\u5176\u4e2d\u7528\u4e8e\u6cbb\u7597\u5fc3\u7ede\u75db\u7684645\u4f8b\uff0c\u7528\u4e8e\u6cbb\u7597\u5176\u4ed6\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\uff08\u5305\u62ec\u9ad8\u8840\u538b\u3001\u51a0\u5fc3\u75c5\u3001\u5fc3\u529f\u80fd\u4e0d\u5168\u3001\u8111\u6897\u585e\u7b49\uff09\u7684722\u4f8b\uff1b\u7528\u4e8e\u6cbb\u7597\u8033\u9e23\u3001\u7729\u6655\u7684\u6709143\u4f8b\uff0c\u5360\u6240\u6709\u75c5\u4f8b\u62a5\u544a\u76848.88%\u3002<\/span>
\n<\/span>  <\/span>(\u4e09)\u4e0d\u826f\u53cd\u5e94\u8868\u73b0\u5206\u6790<\/span>
\n<\/span>  \u66f2\u7f8e\u4ed6\u55ea\u7684\u4e0d\u826f\u53cd\u5e94\u8868\u73b0\u5171\u8ba1<\/span>2270\u4f8b\u6b21\uff0c\u4e3b\u8981\u7d2f\u53ca\u7cfb\u7edf-\u5668\u5b98\u4e3a\u80c3\u80a0\u7cfb\u7edf\u635f\u5bb3\uff0865.24%\uff09\u3001\u76ae\u80a4\u53ca\u5176\u9644\u4ef6\u635f\u5bb3\uff0812.60%\uff09\u3001\u4e2d\u67a2\u53ca\u5916\u5468\u795e\u7ecf\u7cfb\u7edf\u635f\u5bb3\uff088.19%\uff09\u3001\u5168\u8eab\u6027\u635f\u5bb3\uff084.41%\uff09\u3001\u5fc3\u8840\u7ba1\u7cfb\u7edf\u635f\u5bb3\uff081.98%\uff09\u3002<\/span>
\n<\/span>  \u4e0d\u826f\u53cd\u5e94\u4e3b\u8981\u8868\u73b0\u4e3a\u6076\u5fc3\u3001\u5455\u5410\u3001\u76ae\u75b9\u3001\u80c3\u80a0\u9053\u4e0d\u9002\u3001\u7619\u75d2\u3001\u5934\u6655\u3001\u5934\u75db\u3001\u5fc3\u60b8\u7b49\u3002\u5176\u4e2d\u6709<\/span>20\u4f8b\u8fd0\u52a8\u529f\u80fd\u969c\u788d\uff0c\u8868\u73b0\u4e3a\u9707\u98a4\uff0814\u4f8b\u6b21\uff09\u3001\u6b65\u5e45\u51cf\u5c0f\uff083\u4f8b\u6b21\uff09\u3001\u8fd0\u52a8\u969c\u788d\uff082\u4f8b\u6b21\uff09\u548c\u820c\u9ebb\u75f9\uff081\u4f8b\u6b21\uff09\uff1b2\u4f8b\u6b21\u809d\u529f\u80fd\u5f02\u5e38\uff1b\u672a\u6536\u5230\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3001\u7c92\u7ec6\u80de\u7f3a\u4e4f\u75c7\u7684\u4e0d\u826f\u53cd\u5e94\/\u4e8b\u4ef6\u62a5\u544a\u3002<\/span><\/span>\n<\/p>\n

\n\t  <\/span><\/span>\u56db\u3001<\/span>WHO\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u60c5\u51b5<\/span><\/b>
\n<\/span><\/b>  \u622a\u81f3<\/span>2013\u5e7412\u670831\u65e5\uff0cWHO\u5171\u6536\u5230\u66f2\u7f8e\u4ed6\u55ea\u7684\u4e0d\u826f\u53cd\u5e94\u62a5\u544a1193\u4f8b\uff0c\u6d89\u53ca1642\u4f8b\u6b21\uff0c\u4e3b\u8981\u7d2f\u53ca\u7cfb\u7edf-\u5668\u5b98\u4e3a\u76ae\u80a4\u53ca\u5176\u9644\u4ef6\u635f\u5bb3\uff0817.05%\uff09\u3001\u4e2d\u67a2\u53ca\u5916\u5468\u795e\u7ecf\u7cfb\u7edf\u635f\u5bb3\uff0816.14%\uff09\u3001\u80c3\u80a0\u7cfb\u7edf\u635f\u5bb3\uff0813.21%\uff09\u7b49\u3002<\/span>
\n<\/span>\u5176\u4e2d\u8fd0\u52a8\u529f\u80fd\u969c\u788d<\/span>45\u4f8b\u6b21\uff0c\u53602.74%\uff1b\u8840\u6db2\u6dcb\u5df4\u7cfb\u7edf\u635f\u5bb397\u4f8b\uff0c\u53605.91%\uff1b\u809d\u80c6\u7cfb\u7edf\u635f\u5bb361\u4f8b\uff0c\u53603.71%\u3002<\/span><\/span>\n<\/p>\n

\n\t  <\/span><\/span>\u4e94\u3001\u5efa\u8bae<\/span><\/span><\/b>
\n<\/span><\/b>  <\/span>(\u4e00)\u66f2\u7f8e\u4ed6\u55ea\u4ec5\u7528\u4e8e\u5bf9\u4e00\u7ebf\u6297\u5fc3\u7ede\u75db\u7597\u6cd5\u63a7\u5236\u4e0d\u4f73\u6216\u65e0\u6cd5\u8010\u53d7\u7684\u7a33\u5b9a\u578b\u5fc3\u7ede\u75db\u60a3\u8005\u7684\u5bf9\u75c7\u6cbb\u7597\uff0c\u4e0d\u518d\u7528\u4e8e\u8033\u9e23\u3001\u7729\u6655\u7684\u6cbb\u7597\u3002<\/span>
\n<\/span>  <\/span>(\u4e8c)\u5e15\u91d1\u68ee\u75c5\u3001\u5e15\u91d1\u68ee\u7efc\u5408\u5f81\u3001\u9707\u98a4\u3001\u4e0d\u5b89\u817f\u7efc\u5408\u5f81\u3001\u4ee5\u53ca\u5176\u4ed6\u76f8\u5173\u7684\u8fd0\u52a8\u969c\u788d\u7981\u7528\u548c\u4e25\u91cd\u80be\u529f\u80fd\u635f\u5bb3\uff08\u808c\u9150\u6e05\u9664\u7387<30 ml\/min\uff09\u8005\u7981\u6b62\u4f7f\u7528\u66f2\u7f8e\u4ed6\u55ea\u3002<\/span>
\n<\/span>  <\/span>(\u4e09)\u4f7f\u7528\u66f2\u7f8e\u4ed6\u55ea\u6cbb\u7597\uff0c\u5e94\u5bc6\u5207\u5173\u6ce8\u66f2\u7f8e\u4ed6\u55ea\u5bfc\u81f4\u7684\u5e15\u91d1\u68ee\u7efc\u5408\u5f81\uff08\u9707\u98a4\u3001\u8fd0\u52a8\u4e0d\u80fd\u3001\u5f20\u529b\u4ea2\u8fdb\uff09\uff0c\u6b65\u6001\u4e0d\u7a33\uff0c\u4e0d\u5b89\u817f\u7efc\u5408\u5f81\uff0c\u5176\u4ed6\u76f8\u5173\u8fd0\u52a8\u969c\u788d\u4ee5\u53ca\u7c92\u7ec6\u80de\u7f3a\u5c11\u75c7\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u6027\u7d2b\u765c\u3001\u809d\u708e\u7b49\u4e0d\u826f\u53cd\u5e94<\/span>
\n<\/span>  <\/span>(\u56db)\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u5bb3\uff08\u808c\u9150\u6e05\u9664\u738730-60 ml\/min\uff09\u60a3\u8005\u548c\u8001\u5e74\u60a3\u8005\uff0c\u7528\u836f\u5242\u91cf\u9700\u9002\u5ea6\u8c03\u6574\u3002<\/span>
\n<\/span>  <\/span>(\u4e94)\u76f8\u5173\u836f\u54c1\u751f\u4ea7\u4f01\u4e1a\u5e94\u5c06\u7528\u836f\u98ce\u9669\u53ca\u65f6\u544a\u77e5\u533b\u52a1\u4eba\u5458\u548c\u60a3\u8005\uff0c\u52a0\u5f3a\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u5de5\u4f5c\uff0c\u91c7\u53d6\u6709\u6548\u63aa\u65bd\u6700\u5927\u9650\u5ea6\u5730\u4fdd\u969c\u60a3\u8005\u7684\u7528\u836f\u5b89\u5168\u3002<\/span><\/span>\n<\/p>\n

\n\t\u53c2\u8003\u6587\u732e\uff1a<\/span><\/span><\/b>
\n<\/span><\/b>  <\/span>1.Szwed H, Sadowski Z, Elikowski W, Koronkiewicz A, Mamcarz A, Orszulak W etal.Combination treatment in stable effort angina using trimetazidine and metoprolol: results of a randomized, double-blind, multicentre study TRIMPOL II (TRIMetazidine in POLand). Eur Heart J 2001;22(24):2267-74<\/span>
\n<\/span>  <\/span>2.Sellier P, Broustet J. Assessment of anti-ischaemic and anti-anginal effect at trough plasma concentration and safety of trimetazidine MR 35 mg in patients with stable angina pectoris: a multicenter, double-blind, placebocontrolled study. American Journal of Cardiovascular Drugs: drugs devices and other interventions 2003;3(5):361-369.<\/span>
\n<\/span>  <\/span>3.Danchin N, Marzilli M, Parkhomenko A, Ribeiro JP. Efficacy comparison of trimetazidine with therapeutic alternatives in stable angina pectoris: a network meta-analyses. Cardiology 2011; 120 (2): 59-72.<\/span>
\n<\/span>  <\/span>4.Manchanda S.C, Krishnaswami S. Combination treatment with trimetazidine and diltiazemin stable anginapectoris. Heart (British Cardiac Society) 1997;78(4):353-357.<\/span>
\n<\/span>  <\/span>5.Manchanda S.C. Treatment of stable angina with low dose diltiazem in combination with the metabolic agenttrimetazidine. Int J Cardiol 2003;88(1):83-89.<\/span>
\n<\/span>  <\/span>6.Wayoff M. A double-blind placebo-controlled study of the activity of trimetazidine in cochleovestibular disease. La Semaine des Hopitaux de Paris, 1984;60:2729-39.<\/span>
\n<\/span>  <\/span>7.Vitte E, Semont A, Paolino M &Pennaforte S. Assessment of Vastarel\uff1f 35 mg in patients with peripheral vestibular disorder: Double-blind placebo-controlled study using the EquiTest as evaluation criteria. Journal fran\uff1faisdoto-rhinolaryngologie, 2002;51(5):241-6.<\/span>
\n<\/span>  <\/span>8.Haguenauer J.P. A double-blind controlled study versus a reference product of the activity of trimetazidine (Vastarel 20) in the long-term treatment of M\u00e9ni\u00e8re.s disease and vertigo of vascular origin. Le Praticien,1980;360:65-8.<\/span>
\n<\/span>  <\/span>9.Kluyskens P, Lambert P &DHooge D. Trimetazidineversus betahistine in vestibular vertigo. A double blindStudy. Annalesdoto-laryngologie et de chirurgiecervicofaciale : bulletin de la Soci\u00e9t\u00e9doto-laryngologie desh\uff1fpitaux de Paris, 1990;107(Suppl 1): 11-9.<\/span>
\n<\/span>  <\/span>10.Martini A& De Domenico F. Trimetazidineversus betahistine in M\u00e9ni\u00e8res disease. A double blind method. Annalesdoto-laryngologie et de chirurgiecervicofaciale : bulletin de la Soci\u00e9t\u00e9doto-laryngologie des h\uff1fpitauxde Paris, 1990;107(Suppl 1):20-7.<\/span>
\n<\/span>  <\/span>11.Morgon A. A multicenter double blind versus placebo study of trimetazidine in tinnitus. Results obtained after 2months of treatment. Annalesdoto-laryngologieet de chirurgiecervicofaciale. Bulletin de la Soci\u00e9t\u00e9dotolaryngologie des h\uff1fpitaux de Paris, 1990;107(Suppl 1):77-81.<\/span>
\n<\/span>  <\/span>12.Coyas A. A study of the efficacy of trim\u00e9tazidine in the treatment of ischaemia-related cochleovestibular disturbances. A crossover placebo-controlled trial. Ann OtoLaryng 1990;107:82-87.<\/span>
\n<\/span>  <\/span>13.Guillaumat D, Schultz D.S. Vastarel 20mg and ischemic syndromes of the posterior pole of the eye (771 clinicalcases). Tempo Med 1982;110 b,84-88.<\/span>
\n<\/span>  <\/span>14.Millara E, Richetta R, Schutz D. Vastarel 20 mg and chorioretinal ischemic disease. A multicenter study of 1865 patients. Rev OphtalmolFr 1988:37-49.<\/span>
\n<\/span>  <\/span>15.Nowak M.S, Wyb\u00f3r K, Go\uff1f R, A. Miecznik Z, Waszczykowska A, Pastuszka M, K\uff1fysik A, Gajdowska A.Protective effect on visual functions of long-term use of trimetazidine in treatment of primary open angleglaucoma and degenerative myopia. Arch Med Sci. 2007;3,2:152-156.<\/span>
\n<\/span>  <\/span>16.Cornand G. Therapeutic value of Vastarel 20 mg in arteriosclerosis of the optic fundus. Double-blind trialagainst reference drug. Tempo med 1982:110(bis):66-8.<\/span>
\n<\/span>  <\/span>17.CordellaA, Franchi A. Results of trimetazidine : A controlled study versus cinnarizine in degenerative vascular maculopathies. Tempo med 1982;110(bis):68.<\/span>
\n<\/span>  <\/span>18.Perdriel F. Electrophysiological study of the pharmacodynamic mechanism of action of trimetazidine. Single blind controlled trial with crossover. Rev OphtalmolFr 1988;21-7.<\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

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