{"id":3712,"date":"2013-08-07T09:00:28","date_gmt":"2013-08-07T01:00:28","guid":{"rendered":"http:\/\/localhost:9966\/?p=3712"},"modified":"2026-06-23T15:47:03","modified_gmt":"2026-06-23T07:47:03","slug":"%e8%8d%af%e5%93%81%e4%b8%8d%e8%89%af%e5%8f%8d%e5%ba%94%e4%bf%a1%e6%81%af%e9%80%9a%e6%8a%a5%ef%bc%88%e7%ac%ac55%e6%9c%9f%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.blpa.com.cn\/?p=3712","title":{"rendered":"\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u4fe1\u606f\u901a\u62a5\uff08\u7b2c55\u671f\uff09"},"content":{"rendered":"

\n\t\u8b66\u60d5\u8d28\u5b50\u6cf5\u6291\u5236\u5242\u7684\u9aa8\u6298\u3001\u4f4e\u9541\u8840\u75c7\u98ce\u9669\u4ee5\u53ca<\/span><\/span><\/span>\n<\/p>\n

\n\t\u4e0e\u6c2f\u5421\u683c\u96f7\u7684\u76f8\u4e92\u4f5c\u7528<\/span><\/span><\/span>\n<\/p>\n

\n\t\u53d1\u5e03\u65e5\u671f\uff1a<\/span>2013-05-31<\/span><\/span><\/b>\n<\/p>\n

\n\t<\/span>\n<\/p>\n

\n\t\u7f16\u8005\u6309\uff1a<\/span><\/span>
\n<\/span>  \u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u4fe1\u606f\u901a\u62a5\u5236\u5ea6\u662f\u6211\u56fd\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u90e8\u95e8\u4e3a\u4fdd\u969c\u516c\u4f17\u7528\u836f\u5b89\u5168\u800c\u5efa\u7acb\u7684\u4e00\u9879\u5236\u5ea6\u3002\u300a\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u4fe1\u606f\u901a\u62a5\u300b\uff08\u4ee5\u4e0b\u7b80\u79f0\u300a\u901a\u62a5\u300b\uff09\u516c\u5f00\u53d1\u5e03\u4ee5\u6765\uff0c\u4e3a\u63a8\u52a8\u6211\u56fd\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u5de5\u4f5c\uff0c\u4fdd\u969c\u5e7f\u5927\u4eba\u6c11\u7fa4\u4f17\u7528\u836f\u5b89\u5168\u8d77\u5230\u4e86\u79ef\u6781\u7684\u4f5c\u7528\u3002<\/span><\/span>
\n<\/span>  \u672c\u671f\u901a\u62a5\u7684\u54c1\u79cd\u4e3a\u8d28\u5b50\u6cf5\u6291\u5236\u5242\u3002\u7531\u4e8e\u53d1\u73b0\u8be5\u7c7b\u4ea7\u54c1\u53ef\u80fd\u5f15\u8d77\u9aa8\u6298\u3001\u4f4e\u9541\u8840\u75c7\u7b49\u98ce\u9669\uff0c\u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5bf9\u8be5\u7c7b\u4ea7\u54c1\u7684\u5b89\u5168\u6027\u95ee\u9898\u548c\u56fd\u5185\u5916\u7814\u7a76\u8fdb\u5c55\u5bc6\u5207\u5173\u6ce8\uff0c\u5e76\u5f00\u5c55\u4e86\u8bc4\u4f30\u5de5\u4f5c\u3002\u4e3a\u4f7f\u516c\u4f17\u53ca\u65f6\u4e86\u89e3\u8d28\u5b50\u6cf5\u6291\u5236\u5242\u7684\u76f8\u5173\u98ce\u9669\uff0c\u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u7279\u53d1\u5e03\u6b64\u671f\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u4fe1\u606f\u901a\u62a5\uff0c\u4ee5\u8fdb\u4e00\u6b65\u89c4\u8303\u8d28\u5b50\u6cf5\u6291\u5236\u5242\u4e34\u5e8a\u5e94\u7528\uff0c\u964d\u4f4e\u5176\u4f7f\u7528\u98ce\u9669\uff0c\u4fdd\u969c\u516c\u4f17\u7528\u836f\u5b89\u5168\u3002<\/span><\/span><\/span>\n<\/p>\n

\n\t
\n<\/span>\u8b66\u60d5\u8d28\u5b50\u6cf5\u6291\u5236\u5242\u7684\u9aa8\u6298\u3001\u4f4e\u9541\u8840\u75c7\u98ce\u9669\u4ee5\u53ca<\/span><\/span><\/b><\/span><\/b>\n<\/p>\n

\n\t\u4e0e\u6c2f\u5421\u683c\u96f7\u7684\u76f8\u4e92\u4f5c\u7528<\/span><\/span><\/b><\/span>\n<\/p>\n

\n\t  \u8d28\u5b50\u6cf5\u6291\u5236\u5242\uff08<\/span>Proton Pump Inhibitor, PPI\uff09\uff0c\u662f\u4e00\u7c7b\u6291\u5236\u80c3\u9178\u5206\u6ccc\u7684\u836f\u7269\uff0c\u4e5f\u79f0H+-K+ ATP\u9176\u6291\u5236\u5242\uff0c\u53ef\u4ee5\u7279\u5f02\u6027\u548c\u975e\u7ade\u4e89\u6027\u5730\u4f5c\u7528\u4e8e\u80c3\u9178\u5206\u6ccc\u7684\u7ec8\u672b\u73af\u8282\u2014\u2014\u80c3\u58c1\u7ec6\u80de\u4e0a\u7684H+-K+ ATP\u9176\u3002\u76ee\u524d\u4e34\u5e8a\u5e94\u7528\u8d28\u5b50\u6cf5\u6291\u5236\u5242\u6cbb\u7597\u7684\u76f8\u5173\u6027\u75be\u75c5\u4e3b\u8981\u6709\uff1a\u6d88\u5316\u6027\u6e83\u75a1\u3001\u5e7d\u95e8\u87ba\u6746\u83cc\u611f\u67d3\u3001\u80c3\u98df\u7ba1\u53cd\u6d41\u75c5\u3001\u4e0a\u6d88\u5316\u9053\u51fa\u8840\u3001Zollinger-Ellison\u7efc\u5408\u5f81\u3001\u975e\u753e\u4f53\u6297\u708e\u836f\uff08NSAIDS\uff09\u76f8\u5173\u6027\u6e83\u75a1\u3001\u6d88\u5316\u4e0d\u826f\u3001\u5e94\u6fc0\u6027\u6e83\u75a1\u3001Barrett\u98df\u7ba1\u7b49\u75be\u75c5\u3002\u56fd\u5185\u6279\u51c6\u4e0a\u5e02\u7684\u8d28\u5b50\u6cf5\u6291\u5236\u5242\u7c7b\u4ea7\u54c1\u5305\u62ec\uff1a\u5965\u7f8e\u62c9\u5511\u3001\u6cee\u6258\u62c9\u5511\u3001\u5170\u7d22\u62c9\u5511\u3001\u96f7\u8d1d\u62c9\u5511\u3001\u57c3\u7d22\u7f8e\u62c9\u5511\u3002<\/span>
\n<\/span>  \u8fd1\u51e0\u5e74\uff0c\u7f8e\u56fd\u3001\u6b27\u76df\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u90e8\u95e8\u5148\u540e\u53d1\u5e03\u4e86\u6709\u5173\u8d28\u5b50\u6cf5\u6291\u5236\u5242\u7c7b\u836f\u54c1\u7684\u5b89\u5168\u6027\u4fe1\u606f\uff0c\u8b66\u793a\u6b64\u7c7b\u836f\u54c1\u7684\u9aa8\u6298\u3001\u4f4e\u9541\u8840\u75c7\u7b49\u98ce\u9669\u4ee5\u53ca\u4e0e\u6c2f\u5421\u683c\u96f7\u7684\u836f\u7269\u76f8\u4e92\u4f5c\u7528\uff0c\u5e76\u4fee\u8ba2\u4e86\u836f\u54c1\u8bf4\u660e\u4e66\u3002\u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u9488\u5bf9\u5176\u5b89\u5168\u6027\u95ee\u9898\u8fdb\u884c\u4e86\u5206\u6790\u548c\u8bc4\u4f30\uff0c\u7279\u53d1\u5e03\u6b64\u671f\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u4fe1\u606f\u901a\u62a5\uff0c\u63d0\u9192\u5e7f\u5927\u533b\u52a1\u4eba\u5458\u53ca\u60a3\u8005\u5728\u4f7f\u7528\u8d28\u5b50\u6cf5\u6291\u5236\u5242\u524d\uff0c\u8be6\u7ec6\u4e86\u89e3\u672c\u54c1\u53ef\u80fd\u5b58\u5728\u7684\u7528\u836f\u98ce\u9669\uff0c\u907f\u514d\u6216\u51cf\u5c11\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f\u3002<\/span><\/span><\/span>\n<\/p>\n

\n\t  <\/span><\/span>\u4e00\u3001\u9aa8\u6298\u98ce\u9669<\/span><\/span><\/b>
\n<\/span><\/b>  \u51e0\u9879\u6d41\u884c\u75c5\u5b66\u7814\u7a76\u62a5\u544a\u53d1\u73b0\u957f\u671f\u5e94\u7528\u6216\u9ad8\u5242\u91cf\u4f7f\u7528\u8d28\u5b50\u6cf5\u6291\u5236\u5242\u53ef\u5f15\u8d77\u60a3\u8005\u5c24\u5176\u662f\u8001\u5e74\u60a3\u8005\u9acb\u9aa8\u3001\u8155\u9aa8\u3001\u810a\u9aa8\u9aa8\u6298\u7684\u98ce\u9669\u3002\u4e3a\u6b64\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u7ba1\u7406\u5c40\uff08<\/span>FDA\uff09\u5148\u540e\u5bf9\u6b64\u98ce\u9669\u8fdb\u884c\u4e86\u8bc4\u4f30\uff0c\u8ba4\u4e3a\u957f\u671f\u4f7f\u7528\u6216\u9ad8\u5242\u91cf\u4f7f\u7528\u8d28\u5b50\u6cf5\u6291\u5236\u5242\u4e0e\u9acb\u9aa8\u3001\u8155\u9aa8\u3001\u810a\u9aa8\u9aa8\u6298\u5b58\u5728\u4e00\u5b9a\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u76ee\u524d\u6b63\u5728\u8ba1\u5212\u4fee\u8ba2\u6b64\u7c7b\u836f\u54c1\u7684\u8bf4\u660e\u4e66\u8b66\u793a\u4fe1\u606f\u3002<\/span>
\n<\/span>  \uff08\u4e00\uff09\u9aa8\u6298\u98ce\u9669\u53ca\u8bc1\u636e<\/span><\/span>
\n<\/span>  <\/span>FDA\u8ba1\u5212\u4fee\u8ba2\u8d28\u5b50\u6cf5\u6291\u5236\u5242\u8bf4\u660e\u4e66\u7684\u51b3\u5b9a\u662f\u57fa\u4e8e\u5bf9\u591a\u9879\u516c\u5f00\u53d1\u8868\u7684\u6d41\u884c\u75c5\u5b66\u7814\u7a76\u7684\u8c03\u67e5\u5206\u6790\u3002\u8fd9\u4e9b\u7814\u7a76\u5bf9\u4f7f\u7528\u548c\u672a\u4f7f\u7528PPI\u7684\u60a3\u8005\u8fdb\u884c\u4e86\u6bd4\u8f83\uff0c\u7814\u7a76\u5bf9\u8c61\u9650\u5236\u5728\u672c\u8eab\u65e0\u4e25\u91cd\u9aa8\u6298\u98ce\u9669\u7684\u4eba\u7fa4\u3002\u7814\u7a76\u53d1\u73b0\u957f\u671f\u4f7f\u7528PPI\u548c\u8f83\u9ad8\u5242\u91cf\u4f7f\u7528PPI\u53ef\u4f7f\u9aa8\u6298\u98ce\u9669\u5347\u9ad8\uff0c\u5347\u9ad8\u7684\u98ce\u9669\u4e3b\u8981\u662f\u5728\u8001\u5e74\u60a3\u8005\u4e2d\u53d1\u73b0\u7684\u3002<\/span>
\n<\/span>  <\/span>FDA\u672a\u88ab\u5141\u8bb8\u67e5\u770b\u8fd9\u4e9b\u7814\u7a76\u7684\u539f\u59cb\u6570\u636e\u6216\u8bb0\u5f55\u3002\u6839\u636eFDA\u5bf9\u8fd9\u4e9b\u6587\u7ae0\u7684\u5ba1\u67e5\uff0c\u7814\u7a76\u8bbe\u8ba1\u79d1\u5b66\uff0c\u8003\u8651\u4e86PPI\u7684\u5242\u91cf\u548c\u4f7f\u7528\u65f6\u95f4\u7b49\u56e0\u7d20\uff0c\u5e76\u91c7\u53d6\u6070\u5f53\u7684\u7edf\u8ba1\u5b66\u65b9\u6cd5\u51cf\u5c11\u8bf8\u5982\u5e74\u9f84\u3001\u6027\u522b\u3001\u6f5c\u5728\u75be\u75c5\u3001\u5408\u5e76\u7528\u836f\u7b49\u56e0\u7d20\u5e26\u6765\u7684\u504f\u5dee\u3002\u7136\u800c\uff0c\u4e00\u4e9b\u7814\u7a76\u7684\u9650\u5236\u6027\u56e0\u7d20\u4e5f\u4f7fPPI\u4e0e\u9aa8\u6298\u7684\u5173\u8054\u6027\u8bc4\u4ef7\u4ea7\u751f\u4e86\u56f0\u96be\uff0c\u5bf9\u8fd9\u4e9b\u6570\u636e\u7684\u5206\u6790\u4e0d\u80fd\u5305\u542b\u6240\u6709\u53ef\u80fd\u5f71\u54cd\u5173\u8054\u6027\u8bc4\u4ef7\u7684\u6f5c\u5728\u98ce\u9669\u56e0\u7d20\uff0c\u5982\u5bb6\u65cf\u53f2\u3001\u5438\u70df\u53f2\u3001\u4f53\u91cd\u548c\u8eab\u9ad8\u3001\u996e\u9152\u53f2\u3001\u8282\u98df\u548c\u9499\u53ca\u7ef4\u751f\u7d20D\u7b49\u7684\u8865\u5145\u60c5\u51b5\u3001OTC\u836f\u7684\u4f7f\u7528\u60c5\u51b5\u548c\u6d88\u5316\u6027\u75be\u75c5\u7684\u5f71\u54cd\u7b49\u3002\u6709\u5173PPI\u5bfc\u81f4\u9aa8\u6298\u98ce\u9669\u5347\u9ad8\u7684\u673a\u5236\u5c1a\u4e0d\u6e05\u695a\uff0c FDA\u8ba4\u4e3a\u5173\u4e8e\u4e8c\u8005\u5173\u8054\u5173\u7cfb\u9700\u8981\u66f4\u591a\u6570\u636e\u6765\u8bc1\u5b9e\u3002FDA\u8ba1\u5212\u5206\u6790\u51e0\u9879\u6709\u5173\u4e8c\u81a6\u9178\u76d0\uff08\u7528\u4e8e\u9884\u9632\u9aa8\u6298\uff09\u7684\u5927\u578b\u3001\u957f\u671f\u3001\u5b89\u6170\u5242\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ee5\u8bc4\u4f30\u4f7f\u7528\u4e86\u8d28\u5b50\u6cf5\u6291\u5236\u5242\u548c\u672a\u4f7f\u7528\u8be5\u7c7b\u4ea7\u54c1\u7684\u9aa8\u8d28\u758f\u677e\u75c7\u5987\u5973\u7684\u9aa8\u6298\u98ce\u9669\u3002\u603b\u4e4b\uff0c\u76ee\u524d\u5df2\u83b7\u5f97\u7684\u6570\u636e\u63d0\u793a\u4f7f\u7528\u8d28\u5b50\u6cf5\u6291\u5236\u5242\u53ef\u80fd\u5bfc\u81f4\u9acb\u9aa8\u3001\u8155\u9aa8\u3001\u810a\u9aa8\u9aa8\u6298\u98ce\u9669\u5347\u9ad8\uff0c\u5e76\u63d0\u793a\u5347\u9ad8\u7684\u98ce\u9669\u53ef\u80fd\u4e0e\u5242\u91cf\u3001\u7528\u836f\u65f6\u95f4\u76f8\u5173\uff0c\u4f46\u98ce\u9669\u5f3a\u5ea6\u65e0\u6cd5\u786e\u5b9a\u3002FDA\u8981\u6c42\u533b\u751f\u5728\u5904\u65b9\u8d28\u5b50\u6cf5\u6291\u5236\u5242\u65f6\u5e94\u8003\u8651\u4f4e\u5242\u91cf\u3001\u77ed\u7597\u7a0b\u7684\u6cbb\u7597\u65b9\u5f0f\u3002<\/span>
\n<\/span>  \uff08\u4e8c\uff09\u56fd\u5185\u5916\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u60c5\u51b5<\/span><\/span>
\n<\/span>  \u68c0\u7d22\u56fd\u5bb6\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u4e2d\u5fc3\u6570\u636e\u5e93\uff0c\u622a\u81f3<\/span>2012\u5e745\u67081\u65e5\uff0c\u5c1a\u672a\u6536\u5230\u9aa8\u6298\u7684\u75c5\u4f8b\u62a5\u544a\u3002<\/span>
\n<\/span>  \u68c0\u7d22\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\uff08<\/span>WHO\uff09\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u6570\u636e\u5e93\uff0c\u622a\u81f32012\u5e745\u67081\u65e5\uff0c\u6211\u56fd\u4e0a\u5e02\u76845\u4e2aPPI\u7c7b\u836f\u7269\u4e2d\uff0c\u9aa8\u6298\u76f8\u5173\u7684\u4e0d\u826f\u53cd\u5e94\u5171\u8ba1585\u4f8b\u6b21\u3002<\/span><\/span>\n<\/p>\n

\n\t  <\/span><\/span>\u4e8c\u3001\u4f4e\u9541\u8840\u75c7\u98ce\u9669<\/span><\/span><\/b>
\n<\/span><\/b>  \u7f8e\u56fd<\/span>FDA\u548c\u6b27\u76df\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u6700\u8fd1\u4e24\u5e74\u9646\u7eed\u53d1\u5e03\u901a\u544a\uff0c\u63d0\u9192\u4f7f\u7528PPI3\u4e2a\u6708\u4ee5\u4e0a\u4f1a\u6709\u4f4e\u9541\u8840\u75c7\u7684\u98ce\u9669\u3002\u4f4e\u9541\u8840\u75c7\u7684\u4e25\u91cd\u8868\u73b0\u4e3b\u8981\u6709\u75b2\u52b3\u3001\u624b\u8db3\u6410\u6426\u3001\u8c35\u5984\u3001\u60ca\u53a5\u3001\u5934\u6655\u53ca\u5ba4\u6027\u5fc3\u5f8b\u5931\u5e38\u3002\u56e0\u6b64\u5bf9\u4e8e\u9700\u8981\u957f\u671f\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u5c24\u5176\u662f\u540c\u65f6\u5408\u5e76\u4f7f\u7528\u5176\u5b83\u53ef\u81f4\u4f4e\u9541\u8840\u75c7\u7684\u836f\u7269\u65f6\uff0c\u533b\u52a1\u4eba\u5458\u5e94\u8be5\u8003\u8651\u5728PPI\u6cbb\u7597\u4e4b\u524d\u8fdb\u884c\u8840\u9541\u68c0\u67e5\u5e76\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u5b9a\u671f\u68c0\u67e5\u3002<\/span>
\n<\/span>  \uff08\u4e00\uff09\u4f4e\u9541\u8840\u75c7\u98ce\u9669\u53ca\u8bc1\u636e<\/span><\/span>
\n<\/span>  <\/span>FDA\u5ba1\u67e5\u4e86\u836f\u54c1\u4e0d\u826f\u4e8b\u4ef6\u62a5\u544a\u7cfb\u7edf\uff08AERS\uff09\u3001\u533b\u5b66\u6587\u732e\u548c\u5b9a\u671f\u5b89\u5168\u6027\u66f4\u65b0\u62a5\u544a\u4e2d\u6709\u5173\u957f\u671f\u4f7f\u7528PPI\u7684\u4f4e\u9541\u8840\u75c7\u75c5\u4f8b\u62a5\u544a\uff0c\u91cd\u70b9\u5173\u6ce8\u4e8638\u4f8bAERS\u62a5\u544a\u548c23\u4f8b\u6587\u732e\u62a5\u544a\uff08\u5176\u4e2d\u81f3\u5c11\u67098\u4f8b\u786e\u8ba4\u4e3aAERS\u4e2d\u7684\u62a5\u544a\uff09\u3002AERS\u4e2d\u7684\u75c5\u4f8b\u6392\u9664\u4e86\u60a3\u8005\u6b63\u5728\u4f7f\u7528\u5229\u5c3f\u5242\u7684\u60c5\u51b5\uff0c\u6587\u732e\u62a5\u544a\u4e2d\u6709\u7684\u60a3\u8005\u4f7f\u7528\u4e86\u5229\u5c3f\u5242\uff0c\u4f46\u5229\u5c3f\u5242\u7684\u6539\u53d8\u4e0e\u8840\u9541\u6c34\u5e73\u5347\u9ad8\u65e0\u5173\u6216\u8840\u9541\u6c34\u5e73\u5347\u9ad8\u5e76\u505c\u7528\u4e86PPI\u3002FDA\u8bc4\u4f30\u8ba4\u4e3a\u4f4e\u9541\u8840\u75c7\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u4e0e\u957f\u671f\u4f7f\u7528PPI\u6709\u5173\u3002\u4f46\u7531\u4e8e\u4f4e\u9541\u8840\u75c7\u4e0d\u6613\u88ab\u67e5\u89c9\uff0c\u6216\u4f4e\u62a5\u73b0\u8c61\u7684\u5b58\u5728\uff0c\u73b0\u6709\u7684\u6570\u636e\u65e0\u6cd5\u5b9a\u91cf\u5206\u6790PPI\u6cbb\u7597\u5bfc\u81f4\u4f4e\u9541\u8840\u75c7\u7684\u53d1\u751f\u7387\u3002\u6210\u4eba\u62a5\u544a\u4e2d\uff0c\u53d1\u751f\u4f4e\u9541\u8840\u75c7\u7684\u60a3\u8005\u4f7f\u7528PPI\u81f3\u5c113\u4e2a\u6708\uff0c\u4f46\u7edd\u5927\u591a\u6570\u90fd\u662f\u5728\u4f7f\u75281\u5e74\u540e\u53d1\u751f\u7684\u3002\u7ea6\u56db\u5206\u4e4b\u4e00\u7684\u75c5\u4f8b\u62a5\u544a\u663e\u793a\u5355\u72ec\u8865\u5145\u9541\u5143\u7d20\u4e0d\u80fd\u6539\u5584\u4f4e\u9541\u8840\u75c7\uff0c\u5fc5\u987b\u505c\u6b62\u4f7f\u7528PPI\u3002\u4e00\u4e9b\u75c5\u4f8b\u8bb0\u5f55\u4e86\u9633\u6027\u53bb\u6fc0\u53d1\u548c\u9633\u6027\u518d\u6fc0\u53d1\u8fc7\u7a0b\uff08\u5373\u505c\u6b62\u4f7f\u7528PPI\u4f4e\u9541\u8840\u75c7\u597d\u8f6c\uff0c\u518d\u6b21\u4f7f\u7528PPI\u4f4e\u9541\u8840\u75c7\u518d\u6b21\u51fa\u73b0\uff09\u3002\u5728\u505c\u6b62\u4f7f\u7528PPI\u540e\uff0c\u8840\u9541\u6c34\u5e73\u6062\u590d\u6b63\u5e38\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a\u4e00\u5468\u3002\u518d\u6b21\u4f7f\u7528PPI\u5e76\u518d\u6b21\u51fa\u73b0\u4f4e\u9541\u8840\u75c7\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a\u4e24\u5468\u3002<\/span>
\n<\/span>  <\/span>EMA\u8bc4\u4f30\u4e86\u6b27\u76df\u836f\u7269\u8b66\u6212\u6570\u636e\u5e93\uff08EudraVigilance\uff09\u548cWHO\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u6570\u636e\u5e93\uff08Vigibase\uff09\u7684\u81ea\u53d1\u75c5\u4f8b\u62a5\u544a\u4ee5\u53ca\u6765\u81ea\u533b\u5b66\u6587\u732e\u7684\u75c5\u4f8b\u62a5\u544a\uff0c\u8ba4\u4e3a\u5927\u591a\u6570\u7684\u60a3\u8005\u5728\u8fc7\u53bb\u51e0\u5e74\u4e2d\u5747\u8868\u73b0\u51fa\u4e00\u5b9a\u7684\u4f4e\u9541\u8840\u75c7\u75c7\u72b6\uff0c\u5c3d\u7ba1\u8be5\u4e0d\u826f\u53cd\u5e94\u53ef\u80fd\u8f83\u4e3a\u7f55\u89c1\uff0c\u4f46\u8003\u8651\u5230PPI\u7684\u5e7f\u6cdb\u4f7f\u7528\u3001\u53d1\u751f\u4f4e\u9541\u8840\u75c7\u75c5\u4f8b\u7684\u4e25\u91cd\u6027\u3001\u4ee5\u53ca\u7531\u4e8e\u533b\u52a1\u4eba\u5458\u53ef\u80fd\u7f3a\u4e4f\u610f\u8bc6\u800c\u5bfc\u81f4\u8be5\u4e0d\u826f\u53cd\u5e94\u8bca\u65ad\u548c\u6cbb\u7597\u7684\u5ef6\u8fdf\uff0c\u5efa\u8bae\u5728\u4ea7\u54c1\u7279\u5f81\u6982\u8981\u7684\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9879\u4e2d\u5e94\u5f53\u544a\u77e5\u533b\u52a1\u4eba\u5458\u5982\u4e0b\u4fe1\u606f\uff1a<\/span>
\n<\/span>  <\/span>1.\u5728\u670d\u7528PPI\u81f3\u5c113\u4e2a\u6708\u7684\u60a3\u8005\u4e2d\u5df2\u6709\u4e25\u91cd\u7684\u4f4e\u9541\u8840\u75c7\u62a5\u544a\uff0c\u4f46\u5927\u90e8\u5206\u60a3\u8005\u662f\u670d\u7528\u4e861\u5e74\u3002<\/span>
\n<\/span>  <\/span>2.\u4f4e\u9541\u8840\u75c7\u7684\u4e25\u91cd\u8868\u73b0\u5f62\u5f0f\u4e3b\u8981\u4e3a\u75b2\u52b3\u3001\u624b\u8db3\u6410\u6426\u3001\u8c35\u5984\u3001\u60ca\u53a5\u3001\u5934\u6655\u53ca\u5ba4\u6027\u5fc3\u5f8b\u5931\u5e38\u3002\u4f46\u8fd9\u4e9b\u8868\u73b0\u5728\u521d\u671f\u53ef\u80fd\u662f\u9690\u533f\u7684\u4e14\u6613\u88ab\u5ffd\u89c6\u7684\u3002<\/span>
\n<\/span>  <\/span>3.\u5728\u591a\u6570\u60a3\u8005\u4e2d\uff0c\u4f4e\u9541\u8840\u75c7\u5728\u589e\u52a0\u9541\u6444\u5165\u548c\u505c\u7528PPI\u540e\u5f97\u5230\u597d\u8f6c\u3002<\/span>
\n<\/span>  <\/span>4.\u5bf9\u4e8e\u9700\u8981\u957f\u671f\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u7279\u522b\u662f\u90a3\u4e9b\u540c\u65f6\u670d\u7528\u5730\u9ad8\u8f9b\u6216\u5176\u4ed6\u53ef\u80fd\u5bfc\u81f4\u4f4e\u9541\u8840\u75c7\u836f\u7269\uff08\u5982\u5229\u5c3f\u5242\uff09\u7684\u60a3\u8005\uff0c\u533b\u52a1\u4eba\u5458\u5e94\u5f53\u8003\u8651\u5728\u5f00\u59cbPPI\u6cbb\u7597\u524d\u8fdb\u884c\u8840\u9541\u6d53\u5ea6\u6d4b\u5b9a\uff0c\u5e76\u5728\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u68c0\u67e5\u3002<\/span>
\n<\/span>  <\/span>5\u3001\u4f4e\u9541\u8840\u75c7\u662f\u53ef\u80fd\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u53d1\u751f\u9891\u7387\u672a\u77e5\u3002<\/span>
\n<\/span>  \uff08\u4e8c\uff09\u56fd\u5185\u5916\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u60c5\u51b5<\/span><\/span>
\n<\/span>  \u68c0\u7d22<\/span>WHO\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u6570\u636e\u5e93\uff0c\u622a\u81f32012\u5e745\u67081\u65e5\uff0c\u6211\u56fd\u4e0a\u5e02\u76845\u79cdPPI\u836f\u7269\uff0c\u4f4e\u9541\u8840\u75c7\u6709\u5173\u7684\u4e0d\u826f\u53cd\u5e94\u5171\u8ba1275\u4f8b\u6b21\uff1b5\u79cdPPI\u76f8\u6bd4\u8f83\uff0c\u4f4e\u8840\u9541\u75c7\u7684\u98ce\u9669\u65e0\u660e\u663e\u5dee\u522b\uff0c\u5728\u603b\u75c5\u4f8b\u62a5\u544a\u4e2d\u7684\u6bd4\u7387\u5747\u57280.26%-0.49%\u4e4b\u95f4\u3002<\/span>
\n<\/span>  \u68c0\u7d22\u56fd\u5bb6\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u4e2d\u5fc3\u6570\u636e\u5e93\uff0c\u622a\u81f3<\/span>2012\u5e745\u67081\u65e5\uff0c\u67093\u4f8b\u6cee\u6258\u62c9\u5511\u7684\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\u75c5\u4f8b\u62a5\u544a\u3002\u8fd9\u4e09\u4f8b\u60a3\u8005\u5206\u522b\u56e0\u8111\u51fa\u8840\u3001\u8f93\u5c3f\u7ba1\u7ed3\u77f3\u3001\u8179\u75db\u7b49\u539f\u56e0\u9759\u8109\u6ef4\u6ce8\u6ce8\u5c04\u7528\u6cee\u6258\u62c9\u5511\u94a0\uff0c\u51fa\u73b0\u4f4e\u8840\u9541\u75c7\u72b6\uff0c\u80fd\u8010\u53d7\uff0c\u672a\u505a\u5904\u7406\u5373\u81ea\u884c\u75ca\u6108\u3002\u6839\u636e\u836f\u54c1\u8bf4\u660e\u4e66\uff0c\u8fd9\u4e09\u4f8b\u62a5\u544a\u5747\u5b58\u5728\u8d85\u9002\u5e94\u75c7\u7528\u836f\u95ee\u9898\uff0c\u7528\u836f\u65f6\u95f4\u5747\u57281\u5468\u81f3\u4e24\u5468\u5185\uff0c\u867d\u6709\u4f4e\u8840\u9541\u75c7\u7684\u53d1\u751f\uff0c\u4f46\u56e0\u7528\u836f\u65f6\u95f4\u76f8\u5bf9\u8f83\u77ed\uff0c\u4e0d\u80fd\u5224\u5b9a\u4f4e\u8840\u9541\u75c7\u4e0e\u6ce8\u5c04\u7528\u6cee\u6258\u62c9\u5511\u94a0\u7684\u56e0\u679c\u5173\u7cfb\u3002<\/span><\/span>\n<\/p>\n

\n\t  <\/span><\/span>\u4e09\u3001\u4e0e\u6c2f\u5421\u683c\u96f7\u76f8\u4e92\u4f5c\u7528<\/span><\/span><\/b>
\n<\/span><\/b>  \u6c2f\u5421\u683c\u96f7\u662f\u4e00\u79cd\u6297\u51dd\u8840\u836f\uff0c\u4e3b\u8981\u7528\u4e8e\u6709\u5fc3\u810f\u75c5\u53f2\uff08\u5fc3\u810f\u75c5\u53d1\u4f5c\u6216\u4e2d\u98ce\uff09\u7684\u60a3\u8005\u9884\u9632\u65b0\u7684\u5fc3\u810f\u75c5\u4e8b\u4ef6\u7684\u53d1\u751f\u3002\u7531\u4e8e\u80c3\u707c\u70ed\u548c\u80c3\u6e83\u75a1\u662f\u6c2f\u5421\u683c\u96f7\u53ef\u80fd\u5f15\u53d1\u7684\u526f\u4f5c\u7528\uff0c\u56e0\u6b64\u4f7f\u7528\u6c2f\u5421\u683c\u96f7\u7684\u60a3\u8005\u53ef\u80fd\u540c\u65f6\u4f7f\u7528<\/span>PPI\u4ee5\u9632\u6b62\u6216\u51cf\u8f7b\u76f8\u5173\u75c7\u72b6\u3002\u76ee\u524d\u5df2\u6709\u76f8\u5173\u4e34\u5e8a\u8bc1\u636e\u663e\u793a\u670d\u7528\u67d0\u4e9bPPI\u4f1a\u964d\u4f4e\u6c2f\u5421\u683c\u96f7\u7684\u7597\u6548\uff0c\u4ece\u800c\u4f7f\u5f97\u60a3\u8005\u7684\u8840\u6813\u4e0d\u826f\u4e8b\u4ef6\u589e\u52a0\uff0c\u4f46\u5404\u7c7bPPI\u7684\u6291\u5236\u4f5c\u7528\u5e76\u4e0d\u76f8\u540c\uff0c\u5965\u7f8e\u62c9\u5511\u5bf9\u6c2f\u5421\u683c\u96f7\u7684\u6291\u5236\u4f5c\u7528\u6700\u660e\u663e\uff0c\u5176\u4ed6\u51e0\u79cd\u4ea7\u54c1\u7684\u5f71\u54cd\u8f83\u5f31\u6216\u4e0d\u660e\u663e\u3002<\/span>
\n<\/span>  \u7f8e\u56fd\u548c\u52a0\u62ff\u5927\u5df2\u7ecf\u4fee\u6539\u4e86\u6c2f\u5421\u683c\u96f7\u7684\u8bf4\u660e\u4e66\uff0c\u63d0\u793a\u60a3\u8005\u5e94\u907f\u514d\u5408\u5e76\u4f7f\u7528\u5bf9\u6c2f\u5421\u683c\u96f7\u7684\u6709\u6548\u6027\u5177\u6709\u8f83\u5f3a\u6216\u4e2d\u7b49\u6291\u5236\u4f5c\u7528\u7684<\/span>PPIs\uff0c\u5982\u5965\u7f8e\u62c9\u5511\u3002\u5982\u679c\u6b63\u5728\u4f7f\u7528\u6c2f\u5421\u683c\u96f7\u7684\u60a3\u8005\u5fc5\u987b\u4f7f\u7528PPI\uff0c\u5e94\u8003\u8651\u4f7f\u7528\u4e0d\u4f1a\u4ea7\u751f\u5f3a\u70c8\u76f8\u4e92\u4f5c\u7528\u7684\u836f\u7269\uff0c\u5982\u6cee\u6258\u62c9\u5511\u3002<\/span><\/span>\n<\/p>\n

\n\t  <\/span><\/span>\u56db\u3001\u5efa\u8bae<\/span><\/span><\/b>
\n<\/span><\/b>  \u8d28\u5b50\u6cf5\u6291\u5236\u5242\u662f\u6cbb\u7597\u6d88\u5316\u6027\u6e83\u75a1\u3001\u5e7d\u95e8\u87ba\u6746\u83cc\u611f\u67d3\u7b49\u80c3\u80a0\u9053\u75be\u75c5\u7684\u6709\u6548\u836f\u54c1\u3002\u7531\u4e8e\u60a3\u8005\u53ef\u80fd\u9700\u8981\u957f\u671f\u7528\u836f\uff0c\u56e0\u6b64\u533b\u52a1\u4eba\u5458\u548c\u60a3\u8005\u5e94\u5145\u5206\u91cd\u89c6\u6b64\u7c7b\u836f\u54c1\u7684\u5b89\u5168\u6027\u95ee\u9898\uff0c\u8be6\u7ec6\u4e86\u89e3\u6b64\u7c7b\u836f\u54c1\u7684\u4e0d\u826f\u53cd\u5e94\u3001\u7981\u5fcc\u75c7\u3001\u6ce8\u610f\u4e8b\u9879\u548c\u76f8\u4e92\u4f5c\u7528\u3002\u5728\u6cbb\u7597\u524d\u533b\u751f\u5e94\u8be2\u95ee\u60a3\u8005\u7684\u65e2\u5f80\u75c5\u53f2\uff08\u5982\u5fc3\u8840\u7ba1\u75be\u75c5\u7b49\uff09\u548c\u8054\u5408\u7528\u836f\u60c5\u51b5\uff0c\u5c06\u53ef\u80fd\u5b58\u5728\u7684\u5b89\u5168\u6027\u98ce\u9669\u544a\u77e5\u60a3\u8005\uff0c\u4e3a\u60a3\u8005\u5904\u65b9\u6700\u4f4e\u6709\u6548\u5242\u91cf\u7684\u836f\u54c1\uff0c\u5728\u589e\u52a0\u5242\u91cf\u6216\u8c03\u6574\u6cbb\u7597\u65b9\u6848\u65f6\uff0c\u5e94\u5bc6\u5207\u5173\u6ce8\u60a3\u8005\u7684\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u60c5\u51b5\u3002<\/span><\/span>
\n<\/span>  \u5982\u679c\u60a3\u8005\u957f\u671f\u670d\u7528\u8d28\u5b50\u6cf5\u6291\u5236\u5242\uff0c\u5728\u7528\u836f\u8fc7\u7a0b\u4e2d\uff0c\u8981\u6ce8\u610f\u53ef\u80fd\u51fa\u73b0\u7684\u9aa8\u6298\u98ce\u9669\uff08\u5c24\u5176\u662f\u8001\u5e74\u60a3\u8005\uff09\uff0c\u5b9a\u671f\u76d1\u6d4b\u8840\u9541\u6c34\u5e73\uff0c\u9632\u6b62\u4f4e\u9541\u8840\u75c7\u7684\u51fa\u73b0\u3002<\/span><\/span>
\n<\/span>  \u7531\u4e8e\u8d28\u5b50\u6cf5\u6291\u5236\u5242\u4e0e\u6c2f\u5421\u683c\u96f7\u5b58\u5728\u76f8\u4e92\u4f5c\u7528\uff0c\u5efa\u8bae\u6b63\u5728\u4f7f\u7528\u6c2f\u5421\u683c\u96f7\u7c7b\u7684\u60a3\u8005\u5728\u6cbb\u7597\u524d\uff0c\u4e0e\u533b\u751f\u5c31\u7528\u836f\u5b89\u5168\u6027\u95ee\u9898\u8fdb\u884c\u4ea4\u6d41\uff0c\u4ee5\u786e\u4fdd\u7528\u836f\u5b89\u5168\u3002<\/span><\/span>
\n<\/span>  \u5efa\u8bae\u836f\u54c1\u751f\u4ea7\u4f01\u4e1a\u52a0\u5f3a\u5bf9\u6b64\u7c7b\u836f\u54c1\u5b89\u5168\u6027\u7684\u7814\u7a76\uff0c\u5b8c\u5584\u836f\u54c1\u8bf4\u660e\u4e66\u4e2d\u4e0d\u826f\u53cd\u5e94\u548c\u836f\u54c1\u76f8\u4e92\u4f5c\u7528\u7b49\u4fe1\u606f\uff1b\u52a0\u5f3a\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u529b\u5ea6\uff0c\u786e\u4fdd\u4ea7\u54c1\u7684\u5b89\u5168\u6027\u4fe1\u606f\u53ca\u65f6\u4f20\u8fbe\u7ed9\u60a3\u8005\u548c\u533b\u751f\uff0c\u91c7\u53d6\u6709\u6548\u63aa\u65bd\u4fdd\u969c\u60a3\u8005\u7684\u7528\u836f\u5b89\u5168\u3002<\/span><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

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