{"id":3720,"date":"2012-12-14T09:00:29","date_gmt":"2012-12-14T01:00:29","guid":{"rendered":"http:\/\/localhost:9966\/?p=3720"},"modified":"2026-06-23T15:47:03","modified_gmt":"2026-06-23T07:47:03","slug":"%e8%8d%af%e5%93%81%e4%b8%8d%e8%89%af%e5%8f%8d%e5%ba%94%e4%bf%a1%e6%81%af%e9%80%9a%e6%8a%a5%ef%bc%88%e7%ac%ac51%e6%9c%9f%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.blpa.com.cn\/?p=3720","title":{"rendered":"\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u4fe1\u606f\u901a\u62a5\uff08\u7b2c51\u671f\uff09"},"content":{"rendered":"

\n\t\u8b66\u60d5\u4ed6\u6c40\u7c7b\u836f\u54c1\u8840\u7cd6\u5f02\u5e38\u4e0d\u826f\u53cd\u5e94\u53ca\u4e0e<\/span>HIV\u86cb\u767d\u9176\u6291\u5236\u5242\u7684\u76f8\u4e92\u4f5c\u7528<\/span><\/span>\n<\/p>\n

\n\t\u53d1\u5e03\u65e5\u671f\uff1a<\/span>2012-11-20<\/span><\/span><\/b>\n<\/p>\n

\n\t\u7f16\u8005\u6309\uff1a<\/span><\/span>
\n<\/span>  \u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u4fe1\u606f\u901a\u62a5\u5236\u5ea6\u662f\u6211\u56fd\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u90e8\u95e8\u4e3a\u4fdd\u969c\u516c\u4f17\u7528\u836f\u5b89\u5168\u800c\u5efa\u7acb\u7684\u4e00\u9879\u5236\u5ea6\u3002\u300a\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u4fe1\u606f\u901a\u62a5\u300b\u516c\u5f00\u53d1\u5e03\u4ee5\u6765\uff0c\u4e3a\u63a8\u52a8\u6211\u56fd\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u5de5\u4f5c\uff0c\u4fdd\u969c\u5e7f\u5927\u4eba\u6c11\u7fa4\u4f17\u7528\u836f\u5b89\u5168\u8d77\u5230\u4e86\u79ef\u6781\u7684\u4f5c\u7528\u3002<\/span><\/span>
\n<\/span>  \u672c\u671f\u901a\u62a5\u7684\u54c1\u79cd\u4e3a\u4ed6\u6c40\u7c7b\u964d\u8102\u836f\u3002\u7531\u4e8e\u53d1\u73b0\u8be5\u4ea7\u54c1\u53ef\u80fd\u5f15\u8d77\u8840\u7cd6\u5f02\u5e38\u7b49\u4e0d\u826f\u53cd\u5e94\uff0c\u56fd\u5916\u836f\u54c1\u7ba1\u7406\u90e8\u95e8\u8fd1\u671f\u5bf9\u8be5\u54c1\u79cd\u91c7\u53d6\u4e86\u4fee\u8ba2\u8bf4\u660e\u4e66\u7b49\u98ce\u9669\u63a7\u5236\u63aa\u65bd\u3002\u6211\u56fd\u836f\u54c1\u76d1\u7ba1\u90e8\u95e8\u4e5f\u5728\u4e00\u76f4\u5173\u6ce8\u4ed6\u6c40\u7c7b\u7684\u5b89\u5168\u6027\u95ee\u9898\uff0c\u5e76\u5f00\u5c55\u4e86\u8bc4\u4f30\u5de5\u4f5c\u3002\u6839\u636e\u521d\u6b65\u8bc4\u4ef7\u7ed3\u679c\uff0c\u56fd\u5bb6\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u4e2d\u5fc3\u7279\u53d1\u5e03\u6b64\u671f\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u4fe1\u606f\u901a\u62a5\uff0c\u4ee5\u8fdb\u4e00\u6b65\u8b66\u793a\u4ed6\u6c40\u7c7b\u836f\u54c1\u7684\u98ce\u9669\uff0c\u89c4\u8303\u4e34\u5e8a\u5e94\u7528\uff0c\u4fdd\u969c\u516c\u4f17\u7528\u836f\u5b89\u5168\u3002<\/span><\/span><\/span>\n<\/p>\n

\n\t
\n<\/span>\u8b66\u60d5\u4ed6\u6c40\u7c7b\u836f\u54c1\u8840\u7cd6\u5f02\u5e38\u4e0d\u826f\u53cd\u5e94\u53ca<\/span><\/span><\/b><\/span><\/b>\n<\/p>\n

\n\t\u4e0e<\/span>HIV\u86cb\u767d\u9176\u6291\u5236\u5242\u7684\u76f8\u4e92\u4f5c\u7528<\/span><\/b><\/span>\n<\/p>\n

\n\t  \u4ed6\u6c40\u7c7b\u836f\u7269\uff0c\u5373<\/span>3-\u7f9f-3\u7532\u620a\u4e8c\u9170\u8f85\u9176A(HMG-CoA)\u8fd8\u539f\u9176\u6291\u5236\u5242\uff0c\u4e3a\u4e00\u7c7b\u4e34\u5e8a\u5e7f\u6cdb\u4f7f\u7528\u7684\u53e3\u670d\u964d\u8102\u836f\u3002\u4e3b\u8981\u4f5c\u7528\u4e3a\u964d\u4f4e\u8840\u6db2\u4e2d\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u80c6\u56fa\u9187\u6c34\u5e73\uff0c\u8fbe\u5230\u9884\u9632\u548c\u6cbb\u7597\u5fc3\u8840\u7ba1\u75be\u75c5\uff08\u5982\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u3001\u51a0\u5fc3\u75c5\uff09\u7684\u76ee\u7684\u3002\u56fd\u5185\u4e0a\u5e02\u7684\u4ed6\u6c40\u7c7b\u4ea7\u54c1\u5305\u62ec\uff1a\u8f9b\u4f10\u4ed6\u6c40\u3001\u6d1b\u4f10\u4ed6\u6c40\u3001\u666e\u4f10\u4ed6\u6c40\u3001\u745e\u8212\u4f10\u4ed6\u6c40\u3001\u963f\u6258\u4f10\u4ed6\u6c40\u3001\u6c1f\u4f10\u4ed6\u6c40\u3001\u5339\u4f10\u4ed6\u6c40\u3002<\/span>
\n<\/span>  \u8fd1\u671f\uff0c\u7f8e\u56fd\u3001\u6b27\u76df\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u90e8\u95e8\u5148\u540e\u53d1\u5e03\u4e86\u6709\u5173\u4ed6\u6c40\u7c7b\u836f\u54c1\u7684\u5b89\u5168\u6027\u4fe1\u606f\uff0c\u8b66\u793a\u4ed6\u6c40\u7c7b\u7684\u8840\u7cd6\u5f02\u5e38\u7b49\u4e0d\u826f\u53cd\u5e94\u548c\u836f\u7269\u76f8\u4e92\u4f5c\u7528\uff0c\u5e76\u4fee\u8ba2\u4e86\u836f\u54c1\u8bf4\u660e\u4e66\u3002\u56fd\u5bb6\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u4e2d\u5fc3\u9488\u5bf9\u5176\u5b89\u5168\u6027\u95ee\u9898\u8fdb\u884c\u4e86\u5206\u6790\u548c\u8bc4\u4f30\uff0c\u5e76\u5411\u5e7f\u5927\u533b\u52a1\u4eba\u5458\u548c\u516c\u4f17\u53d1\u5e03\u6b64\u671f\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u4fe1\u606f\u901a\u62a5\uff0c\u4ee5\u4fc3\u8fdb\u4e34\u5e8a\u5b89\u5168\u3001\u5408\u7406\u4f7f\u7528\u4ed6\u6c40\u7c7b\u836f\u54c1\u3002<\/span><\/span>
\n<\/span>  <\/span><\/span>\u4e00\u3001\u8840\u7cd6\u5f02\u5e38<\/span><\/span><\/b>
\n<\/span><\/b>  \u8840\u7cd6\u5f02\u5e38\u4e3a\u4ed6\u6c40\u7c7b\u65b0\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u53ca\u4e2a\u4f8b\u62a5\u544a\u53d1\u73b0\u8be5\u7c7b\u836f\u54c1\u53ef\u5f15\u8d77\u60a3\u8005\u8840\u7cd6\u5f02\u5e38\uff0c\u8868\u73b0\u4e3a\u7a7a\u8179\u8840\u7cd6\u6c34\u5e73\u5347\u9ad8\u3001\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\u6c34\u5e73\u5347\u9ad8\u3001\u65b0\u53d1\u7cd6\u5c3f\u75c5\u3001\u7cd6\u5c3f\u75c5\u8840\u7cd6\u63a7\u5236\u6076\u5316\u7b49\u3002\u4e3a\u6b64\uff0c\u6b27\u76df\u548c\u7f8e\u56fd\u836f\u54c1\u76d1\u7ba1\u90e8\u95e8\u5148\u540e\u5bf9\u6b64\u98ce\u9669\u8fdb\u884c\u4e86\u8bc4\u4f30\uff0c\u5e76\u5f97\u51fa\u4e86\u76f8\u4f3c\u7684\u7ed3\u8bba\uff0c\u8ba4\u4e3a\u4ed6\u6c40\u7c7b\u7684\u4f7f\u7528\u4e0e\u65b0\u53d1\u7cd6\u5c3f\u75c5\u3001\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\u548c<\/span>\/\u6216\u7a7a\u8179\u8840\u7cd6\u6c34\u5e73\u5347\u9ad8\u5b58\u5728\u8f83\u4e3a\u660e\u786e\u7684\u76f8\u5173\u6027\u3002<\/span>
\n<\/span>  \uff08\u4e00\uff09\u8840\u7cd6\u5f02\u5e38\u98ce\u9669\u53ca\u8bc1\u636e<\/span><\/span>
\n<\/span>  \u4e0e\u4ed6\u6c40\u7c7b\u836f\u54c1\u76f8\u5173\u7684\u4e34\u5e8a\u8bd5\u9a8c\u548c\u835f\u8403\u5206\u6790\u8bc1\u5b9e\u4e86\u6b64\u7c7b\u836f\u7269\u4e0e\u8840\u7cd6\u5f02\u5e38\u98ce\u9669\u7684\u76f8\u5173\u6027\u3002\u6709\u5173\u745e\u8212\u4f10\u4ed6\u6c40\u7684\u4e00\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff08<\/span>JUPITER\uff09\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u63a5\u53d7\u5b89\u6170\u5242\u6cbb\u7597\u7684\u60a3\u8005\u76f8\u6bd4\uff0c\u745e\u8212\u4f10\u4ed6\u6c40\u6cbb\u7597\u7ec4\u60a3\u8005\u4e2d\u62a5\u544a\u7684\u7cd6\u5c3f\u75c5\u589e\u52a0\u4e8627%\u3002\u5728\u6d89\u53ca\u666e\u4f10\u4ed6\u6c40\u548c\u963f\u6258\u4f10\u4ed6\u6c40\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff08PROVE-IT TIMI 22\uff09\u53d1\u73b0\uff0c\u5927\u5242\u91cf\u963f\u6258\u4f10\u4ed6\u6c40\u4e0e\u8840\u7cd6\u63a7\u5236\u6076\u5316\u6709\u5173\u3002Sattar\u7b49\u5bf9\u5305\u62ec91,140\u4f8b\u53d7\u8bd5\u8005\u768413\u9879\u4ed6\u6c40\u7c7b\u836f\u7269\u8bd5\u9a8c\u8fdb\u884c\u4e86\u4e00\u9879\u835f\u8403\u5206\u6790\uff0c\u7ed3\u679c\u8868\u660e\u4ed6\u6c40\u7c7b\u836f\u7269\u6cbb\u7597\u53ef\u4f7f\u65b0\u53d1\u7cd6\u5c3f\u75c5\u98ce\u9669\u5347\u9ad89%\uff08OR=1.09\uff1b95%CI 1.02-1.17\uff09\uff0c\u5404\u8bd5\u9a8c\u4e4b\u95f4\u57fa\u672c\u65e0\u5f02\u8d28\u6027\u3002\u7ecf\u7814\u7a76\u8005\u8ba1\u7b97\uff0c\u8be5\u7ed3\u679c\u8868\u793a\u6bcf1000\u4eba\/\u5e74\u5c06\u589e\u52a0\u7ea61\u4f8b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3002Rajpathak\u7b49\u7684\u835f\u8403\u5206\u6790\u5305\u542b\u4e866\u9879\u4ed6\u6c40\u7c7b\u836f\u7269\u8bd5\u9a8c\uff0c\u5171\u8ba157,593\u540d\u53d7\u8bd5\u8005\uff0c\u540c\u6837\u6307\u51fa\u7cd6\u5c3f\u75c5\u98ce\u9669\u6709\u8f7b\u5fae\u5347\u9ad8\uff08RR=1.13\uff0c95%CI 1.03-1.23\uff09\uff0c\u4e5f\u6ca1\u6709\u8bc1\u636e\u8bf4\u660e\u5404\u8bd5\u9a8c\u4e4b\u95f4\u5b58\u5728\u5f02\u8d28\u6027\u3002<\/span>
\n<\/span>  \u6b27\u76df\u8bc4\u4f30\u7ed3\u8bba\u8ba4\u4e3a\uff0c\u5df2\u6709\u5145\u5206\u8bc1\u636e\u8bc1\u660e\u4ed6\u6c40\u7c7b\u7684\u4f7f\u7528\u4e0e\u65b0\u53d1\u7cd6\u5c3f\u75c5\u76f8\u5173\uff0c\u5e76\u5c06\u4ed6\u6c40\u7c7b\u5f52\u7c7b\u4e3a\u53ef\u80fd\u5f15\u8d77\u8840\u7cd6\u5347\u9ad8\u7684\u836f\u7269\u3002\u5c3d\u7ba1\u5982\u6b64<\/span>,\u4e0e\u4ed6\u6c40\u7c7b\u6cbb\u7597\u51fa\u73b0\u7684\u7cd6\u5c3f\u75c5\u75c5\u4f8b\u76f8\u6bd4\uff0c\u5728\u76f8\u540c\u6cbb\u7597\u671f\u95f4\u5185\u8be5\u7c7b\u836f\u54c1\u53ef\u51cf\u5c11\u66f4\u591a\u7684\u6b7b\u4ea1\u6216\u5fc3\u808c\u6897\u6b7b\u3001\u4e2d\u98ce\u6216\u51a0\u72b6\u52a8\u8109\u8840\u8fd0\u91cd\u5efa\u75c5\u4f8b\uff0c\u56e0\u6b64\uff0c\u4ed6\u6c40\u7c7b\u836f\u7269\u7684\u6548\u76ca-\u98ce\u9669\u6bd4\u4ecd\u662f\u6b63\u5411\u7684\u3002\u6b27\u76df\u8fdb\u4e00\u6b65\u6307\u51fa\uff0c\u6b64\u98ce\u9669\u4e3b\u8981\u5b58\u5728\u4e8e\u90a3\u4e9b\u5df2\u5b58\u5728\u53d1\u751f\u7cd6\u5c3f\u75c5\u98ce\u9669\u7684\u60a3\u8005\u4e2d\uff0c\u5305\u62ec\u57fa\u7ebf\u7a7a\u8179\u8840\u7cd6\u5347\u9ad8(\u4e3a\u8bc4\u4ef7\u7684\u5173\u952e\u56e0\u7d20)\u3001\u9ad8\u8840\u538b\u53f2\u3001\u7518\u6cb9\u4e09\u916f\u5347\u9ad8\u4ee5\u53ca\u57fa\u7ebf\u4f53\u91cd\u6307\u6570\u589e\u52a0\u3002\u56e0\u6b64\uff0c\u5e94\u5f53\u4f9d\u636e\u76f8\u5173\u6307\u5357\u5bf9\u5371\u9669\u4eba\u7fa4\uff08\u5982\u7a7a\u8179\u8840\u7cd65.6-6.9 mmol\/L\u4e4b\u95f4\uff0c\u4f53\u91cd\u6307\u6570\u5927\u4e8e30kg\/m2\uff0c\u7518\u6cb9\u4e09\u916f\u5347\u9ad8\u6216\u60a3\u9ad8\u8840\u538b\uff09\u5728\u4e34\u5e8a\u75c7\u72b6\u548c\u751f\u5316\u6307\u6807\u4e24\u65b9\u9762\u8fdb\u884c\u76d1\u6d4b\u3002<\/span>
\n<\/span>  \uff08\u4e8c\uff09\u56fd\u5185\u5916\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u60c5\u51b5<\/span><\/span>
\n<\/span>  <\/span>2004\u5e741\u67081\u65e5\u81f32012\u5e743\u670831\u65e5\uff0c\u56fd\u5bb6\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u4e2d\u5fc3\u75c5\u4f8b\u62a5\u544a\u6570\u636e\u5e93\u4e2d\u5171\u68c0\u7d22\u52307\u4f8b\u4e0e\u4ed6\u6c40\u7c7b\u836f\u7269\u4f7f\u7528\u53ca\u8840\u7cd6\u5f02\u5e38\u76f8\u5173\u7684\u75c5\u4f8b\uff0c\u6d89\u53ca\u7684\u836f\u54c1\u5305\u62ec\uff1a\u8f9b\u4f10\u4ed6\u6c401\u4f8b\u3001\u963f\u6258\u4f10\u4ed6\u6c403\u4f8b\u3001\u745e\u8212\u4f10\u4ed6\u6c403\u4f8b\u3002\u4e0d\u826f\u53cd\u5e94\u8868\u73b0\u4e3a\uff1a\u8840\u7cd6\u6216\u7a7a\u8179\u8840\u7cd6\u5347\u9ad8\u3001\u65b0\u53d1\u7cd6\u5c3f\u75c5\u7b49\uff0c\u5f00\u59cb\u670d\u836f\u81f3\u53d1\u73b0\u8840\u7cd6\u5f02\u5e38\u4e0d\u826f\u53cd\u5e94\u65f6\u95f4\u4e3a1-3\u4e2a\u6708\uff0c\u4e0d\u826f\u53cd\u5e94\u7ed3\u679c\u5747\u4e3a\u597d\u8f6c\u3002<\/span>
\n<\/span>  \u5178\u578b\u75c5\u4f8b\uff1a\u60a3\u8005\u7537\uff0c<\/span>55\u5c81\uff0c\u56e0\u9ad8\u8840\u538b\u3001\u9ad8\u8840\u8102\u75c7\uff0c\u4e00\u76f4\u670d\u7528\u6c2f\u6c99\u5766\/\u6c22\u6c2f\u567b\u55ea\u3001\u963f\u53f8\u5339\u6797\u3001\u9152\u77f3\u9178\u7f8e\u6258\u6d1b\u5c14\u6cbb\u7597\u30022010\u5e741\u670824\u65e5\u52a0\u670d\u963f\u6258\u4f10\u4ed6\u6c4020mg\/\u6b21\uff0c\u4e00\u65e5\u4e00\u6b21\u964d\u8840\u8102\u6cbb\u7597\uff0c\u7528\u836f\u524d\u6d4b\u8840\u7cd6\uff0c\u9910\u524d\u7a7a\u81796.16mmol\/L,\u9910\u540e2\u5c0f\u65f66.24mmol\/L\uff0c\u670d\u7528\u81f32010\u5e743\u67083\u65e5\u6d4b\u8840\u7cd6\uff0c\u9910\u524d\u7a7a\u81796.95mmol\/L\uff0c\u9910\u540e2\u5c0f\u65f68.45mmol\/L\uff0c\u8840\u7cd6\u5347\u9ad8\u660e\u663e\uff0c\u6000\u7591\u4e3a\u963f\u6258\u4f10\u4ed6\u6c40\u6240\u5f15\u8d77\uff0c\u9042\u505c\u7528\u6b64\u836f\u30022010\u5e743\u670820\u65e5\u6d4b\u9910\u540e2\u5c0f\u65f6\u8840\u7cd6\u964d\u81f3\u6b63\u5e38\uff085.7mmol\/L\uff09\u3002<\/span>
\n<\/span>  \u68c0\u7d22\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u6570\u636e\u5e93\uff0c\u622a\u81f3<\/span>2012\u5e744\u67086\u65e5\uff0c\u6211\u56fd\u4e0a\u5e02\u76848\u4e2a\u4ed6\u6c40\u7c7b\u836f\u7269\u4e2d\uff0c\u6709\u5173\u8840\u7cd6\u5f02\u5e38\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\u5171\u8ba12540\u4f8b\u6b21\uff0c\u4e3b\u8981\u4e0d\u826f\u53cd\u5e94\u8868\u73b0\uff1a\u9ad8\u8840\u7cd6\u3001\u7cd6\u5c3f\u75c5\u3001\u7cd6\u8010\u91cf\u5f02\u5e38\u3001\u7cd6\u5c3f\u75c5\u52a0\u91cd\u3001\u4f4e\u8840\u7cd6\u7b49\u3002\u76f8\u6bd4\u8f83\uff0c\u963f\u6258\u4f10\u4ed6\u6c40\u3001\u745e\u8212\u4f10\u4ed6\u6c40\u7684\u8840\u7cd6\u5f02\u5e38\u62a5\u544a\u6bd4\u4f8b\u8f83\u9ad8\u3002<\/span>
\n<\/span>  <\/span><\/span>\u4e8c\u3001\u836f\u7269\u76f8\u4e92\u4f5c\u7528<\/span><\/span><\/b>
\n<\/span><\/b>  \u4ed6\u6c40\u7c7b\u836f\u7269\u901a\u8fc7\u809d\u9176<\/span>CYP3A4\u4ee3\u8c22\uff0c\u56e0\u6b64\uff0c\u7406\u8bba\u4e0a\u8ba4\u4e3a\u5bf9\u8be5\u9176\u6709\u6291\u5236\u4f5c\u7528\u7684\u836f\u7269\uff0c\u5747\u53ef\u5bfc\u81f4\u4ed6\u6c40\u7c7b\u66b4\u9732\u91cf\u5347\u9ad8\uff0c\u589e\u52a0\u5305\u62ec\u6a2a\u7eb9\u808c\u6eb6\u89e3\u5728\u5185\u7684\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f\u98ce\u9669\u3002\u6b64\u5916\uff0c\u4e00\u4e9b\u7814\u7a76\u4e5f\u8bc1\u5b9e\u4e86\u6b64\u7c7b\u76f8\u4e92\u4f5c\u7528\u98ce\u9669\u7684\u5b58\u5728\u3002<\/span>
\n<\/span>  \u8fd1\u671f\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08<\/span>FDA\uff09\u5bf9\u4ed6\u6c40\u7c7b\u4e0e\u4eba\u7c7b\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\uff08HIV\uff09\u548c\u4e19\u578b\u809d\u708e\u75c5\u6bd2\uff08HCV\uff09\u86cb\u767d\u9176\u6291\u5236\u5242\u7684\u76f8\u4e92\u4f5c\u7528\u8fdb\u884c\u4e86\u8b66\u544a\u3002HIV\u86cb\u767d\u9176\u6291\u5236\u5242\u662f\u6cbb\u7597HIV\u611f\u67d3\u7684\u6297\u75c5\u6bd2\u836f\u7269\uff0c\u5305\u62ec\u6d1b\u5339\u90a3\u97e6\u3001\u8fbe\u82a6\u90a3\u97e6\u3001\u6c99\u594e\u90a3\u97e6\u3001\u963f\u624e\u90a3\u97e6\u3001\u5229\u6258\u90a3\u97e6\u7b49\u3002HCV\u86cb\u767d\u9176\u6291\u5236\u5242\u662f\u7528\u4e8e\u6cbb\u7597\u4e19\u578b\u809d\u708e\u611f\u67d3\u7684\u6297\u75c5\u6bd2\u836f\u7269\uff0c\u5305\u62ec\u6ce2\u666e\u745e\u97e6\uff08boceprevir\uff09\u548c\u66ff\u62c9\u745e\u97e6\uff08telaprevir\uff09\uff0c\u4f46\u5747\u672a\u5728\u6211\u56fd\u6279\u51c6\u4e0a\u5e02\u3002\u8fd9\u4e24\u7c7b\u836f\u54c1\u5747\u4e3aCYP3A4\u6291\u5236\u5242\uff0c\u5408\u5e76\u4f7f\u7528\u53ef\u80fd\u589e\u52a0\u4ed6\u6c40\u7c7b\u7684\u8840\u836f\u6d53\u5ea6\uff0c\u5e76\u589e\u52a0\u808c\u8089\u635f\u4f24\u7684\u98ce\u9669\u3002<\/span>
\n<\/span>  \u9664<\/span>HIV\u548cHCV\u86cb\u767d\u9176\u6291\u5236\u5242\u5916\uff0c\u4e0e\u5176\u4ed6CYP3A4\u6291\u5236\u5242\u6216\u53ef\u80fd\u5f15\u8d77\u808c\u75c5\u7684\u836f\u7269\u5408\u7528\u4e5f\u53ef\u80fd\u5e26\u6765\u540c\u6837\u7684\u98ce\u9669\uff0c\u5982\u4f0a\u66f2\u5eb7\u5511\u3001\u916e\u5eb7\u5511\u3001\u7ea2\u9709\u7d20\u3001\u514b\u62c9\u9709\u7d20\u3001\u6cf0\u5229\u9709\u7d20\u3001\u5948\u6cd5\u5511\u916e\u3001\u73af\u5b62\u7d20\u3001\u80fa\u7898\u916e\u3001\u5730\u5c14\u786b\u5353\u7b49\u3002<\/span>
\n<\/span>  \u4e3a\u63a7\u5236\u836f\u54c1\u76f8\u4e92\u4f5c\u7528\u5e26\u6765\u7684\u98ce\u9669\uff0c\u7f8e\u56fd<\/span>FDA\u4fee\u8ba2\u7684\u8bf4\u660e\u4e66\u9664\u589e\u52a0\u4e86\u5bf9\u4e8e\u4ed6\u6c40\u7c7b\u836f\u7269\u4e0eHIV\u548cHCV\u86cb\u767d\u9176\u6291\u5236\u5242\u76f8\u4e92\u4f5c\u7528\u60c5\u51b5\u7684\u63cf\u8ff0\u5916\uff0c\u90e8\u5206\u54c1\u79cd\u8fd8\u589e\u52a0\u4e86\u5242\u91cf\u9650\u5236\uff0c\u5982\u4e0e\u5948\u975e\u90a3\u97e6\u5408\u7528\uff0c\u963f\u6258\u4f10\u4ed6\u6c40\u65e5\u5242\u91cf\u4e0d\u8d85\u8fc740mg\uff0c\u4e0e\u963f\u624e\u90a3\u97e6\/\u5229\u6258\u90a3\u97e6\u5408\u7528\uff0c\u745e\u8212\u4f10\u4ed6\u6c40\u65e5\u5242\u91cf\u4e0d\u8d85\u8fc710mg\u3002\u6b64\u5916\uff0c\u7531\u4e8e\u6d1b\u4f10\u4ed6\u6c40\u548c\u8f9b\u4f10\u4ed6\u6c40\u5bf9CYP3A4\u9176\u6bd4\u8f83\u654f\u611f\uff0c\u7981\u6b62\u8fd9\u4e24\u79cd\u836f\u54c1\u4e0eHIV\u6216HCV\u86cb\u767d\u9176\u6291\u5236\u5242\u5408\u7528\uff0c\u8be6\u89c1\u4e0b\u8868\u3002<\/span><\/span>\n<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

\n\t\t\t\t\t\u836f\u7269\u540d\u79f0<\/span><\/b><\/span>\n\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\u76f8\u4e92\u4f5c\u7528\u7684\u86cb\u767d\u9176\u6291\u5236\u5242<\/span><\/b><\/span>\n\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\u5efa\u8bae<\/span><\/b><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\u963f\u6258\u4f10\u4ed6\u6c40<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\u66ff\u62c9\u90a3\u97e6+\u5229\u6258\u90a3\u97e6<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\u907f\u514d\u4e0e\u963f\u6258\u4f10\u4ed6\u6c40\u5408\u7528<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\u66ff\u62c9\u745e\u97e6<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\u6d1b\u5339\u90a3\u97e6+\u5229\u6258\u90a3\u97e6<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\u614e\u7528\uff0c\u5c3d\u53ef\u80fd\u7528\u963f\u6258\u4f10\u4ed6\u6c40\u7684\u6700\u5c0f\u5242\u91cf<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\u8fbe\u82a6\u90a3\u97e6+\u5229\u6258\u90a3\u97e6<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\u963f\u6258\u4f10\u4ed6\u6c40\u65e5\u5242\u91cf\u4e0d\u8d85\u8fc720 mg<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\u798f\u6c99\u90a3\u4f1f<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\u798f\u6c99\u90a3\u4f1f+\u5229\u6258\u90a3\u97e6<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\u6c99\u594e\u90a3\u97e6+\u5229\u6258\u90a3\u97e6<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\u5948\u975e\u90a3\u97e6<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\u963f\u6258\u4f10\u4ed6\u6c40\u65e5\u5242\u91cf\u4e0d\u8d85\u8fc740 mg<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\u6c1f\u4f10\u4ed6\u6c40<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t <\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\u65e0\u6570\u636e<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\u6d1b\u4f10\u4ed6\u6c40<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\tHIV \u86cb\u767d\u9176\u6291\u5236\u5242<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\u7981\u5fcc<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\u6ce2\u666e\u745e\u97e6<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\u66ff\u62c9\u745e\u97e6<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\u5339\u4f10\u4ed6\u6c40<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\u963f\u624e\u90a3\u97e6\u00b1\u5229\u6258\u90a3\u97e6<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\u65e0\u5242\u91cf\u9650\u503c<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\u8fbe\u82a6\u90a3\u97e6+\u5229\u6258\u90a3\u97e6<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\u6d1b\u5339\u90a3\u97e6+\u5229\u6258\u90a3\u97e6<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\u5e15\u4f10\u4ed6\u6c40<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\u8fbe\u82a6\u90a3\u97e6+\u5229\u6258\u90a3\u97e6<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\u65e0\u5242\u91cf\u9650\u503c<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\u5339\u90a3\u97e6+\u5229\u6258\u90a3\u97e6<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\u745e\u8212\u4f10\u4ed6\u6c40<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\u963f\u624e\u90a3\u97e6\u00b1\u5229\u6258\u90a3\u97e6<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\u745e\u8212\u4f10\u4ed6\u6c40\u5242\u91cf\u4e0d\u8d85\u8fc710 mg\u6bcf\u65e51\u6b21<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\u6d1b\u5339\u90a3\u97e6+\u5229\u6258\u90a3\u97e6<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\u8f9b\u4f10\u4ed6\u6c40<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\tHIV \u86cb\u767d\u9176\u6291\u5236\u5242<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\u7981\u5fcc<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\u6ce2\u666e\u745e\u97e6<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\u66ff\u62c9\u745e\u97e6<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\n\t
\n<\/span>  <\/span><\/span>\u4e09\u3001\u5efa\u8bae<\/span><\/span><\/b>
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\n<\/span>  \u5bf9\u4e8e\u4ed6\u6c40\u7c7b\u7684\u8840\u7cd6\u5f02\u5e38\u98ce\u9669\uff0c\u5982\u679c\u60a3\u8005\u51fa\u73b0\u591a\u5c3f\u3001\u591a\u996e\u3001\u591a\u98df\u3001\u75b2\u4e4f\u7b49\u6000\u7591\u4e0e\u7cd6\u5c3f\u75c5\u6216\u8840\u7cd6\u7d0a\u4e71\u6709\u5173\u7684\u75c7\u72b6\uff0c\u7acb\u5373\u5411\u533b\u751f\u54a8\u8be2\uff0c\u4ee5\u660e\u786e\u75c5\u56e0\u5e76\u91c7\u53d6\u9002\u5f53\u7684\u5904\u7406\u63aa\u65bd\u3002\u5efa\u8bae\u4f7f\u7528\u4ed6\u6c40\u7c7b\u7684\u7cd6\u5c3f\u75c5\u60a3\u8005\u5bc6\u5207\u76d1\u6d4b\u8840\u7cd6\u72b6\u51b5\uff0c\u5982\u679c\u51fa\u73b0\u8840\u7cd6\u63a7\u5236\u6076\u5316\uff0c\u5e94\u7acb\u5373\u5c31\u8bca\u3002<\/span><\/span>
\n<\/span>  \u7531\u4e8e\u4ed6\u6c40\u7c7b\u4e0e\u8f83\u591a\u836f\u7269\u5b58\u5728\u76f8\u4e92\u4f5c\u7528\uff0c\u5efa\u8bae\u60a3\u8005\u5728\u6cbb\u7597\u524d\u5c06\u6240\u6709\u6b63\u5728\u4f7f\u7528\u7684\u836f\u54c1\u544a\u4e4b\u533b\u751f\uff0c\u5e76\u8ba4\u771f\u9605\u8bfb\u836f\u54c1\u8bf4\u660e\u4e66\uff0c\u4e0e\u533b\u751f\u5c31\u7528\u836f\u7684\u5b89\u5168\u6027\u95ee\u9898\u8fdb\u884c\u6709\u6548\u5730\u7684\u4ea4\u6d41\uff0c\u4fdd\u62a4\u81ea\u8eab\u5065\u5eb7\u5229\u76ca\u3002<\/span><\/span>
\n<\/span>  \u5efa\u8bae\u836f\u54c1\u751f\u4ea7\u4f01\u4e1a\u52a0\u5f3a\u5bf9\u836f\u54c1\u5b89\u5168\u6027\u7684\u7814\u7a76\uff0c\u8fdb\u4e00\u6b65\u5b8c\u5584\u836f\u54c1\u8bf4\u660e\u4e66\u548c\u6807\u7b7e\u4e2d\u4e0d\u826f\u53cd\u5e94\u3001\u76f8\u4e92\u4f5c\u7528\u7b49\u4fe1\u606f\u3002\u52a0\u5f3a\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u529b\u5ea6\uff0c\u52a0\u5f3a\u4e0e\u533b\u751f\u7684\u4fe1\u606f\u6c9f\u901a\uff0c\u91c7\u53d6\u6709\u6548\u63aa\u65bd\u6700\u5927\u9650\u5ea6\u5730\u4fdd\u969c\u60a3\u8005\u7684\u7528\u836f\u5b89\u5168\u3002<\/span><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

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