{"id":3796,"date":"2022-05-11T20:42:45","date_gmt":"2022-05-11T12:42:45","guid":{"rendered":"http:\/\/localhost:9966\/?p=3796"},"modified":"2026-06-23T15:47:05","modified_gmt":"2026-06-23T07:47:05","slug":"%e8%8d%af%e5%93%81%e4%b8%8d%e8%89%af%e5%8f%8d%e5%ba%94%e4%bf%a1%e6%81%af%e9%80%9a%e6%8a%a5%ef%bc%88%e7%ac%ac13%e6%9c%9f%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.blpa.com.cn\/?p=3796","title":{"rendered":"\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u4fe1\u606f\u901a\u62a5\uff08\u7b2c13\u671f\uff09"},"content":{"rendered":"

\n\t\u8b66\u60d5\u542b\u9486\u78c1\u5171\u632f\u9020\u5f71\u5242\u5f15\u8d77\u7684\u80be\u6e90\u6027\u7cfb\u7edf\u7ea4\u7ef4\u5316<\/span><\/span><\/span>\n<\/p>\n

\n\t\u53d1\u5e03\u65e5\u671f\uff1a<\/span>2007-10-29<\/span><\/span><\/b>\n<\/p>\n

\n\t\u7f16\u8005\u6309\uff1a<\/span><\/span><\/span>\n<\/p>\n

\n\t  \u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u4fe1\u606f\u901a\u62a5\u5236\u5ea6\u662f\u6211\u56fd\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u90e8\u95e8\u4e3a\u4fdd\u969c\u516c\u4f17\u7528\u836f\u5b89\u5168\u800c\u5efa\u7acb\u7684\u4e00\u9879\u5236\u5ea6\u3002\u300a\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u4fe1\u606f\u901a\u62a5\u300b\u9762\u5411\u793e\u4f1a\u516c\u5f00\u53d1\u5e03\u4ee5\u6765\uff0c\u5bf9\u63a8\u52a8\u6211\u56fd\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u5de5\u4f5c\uff0c\u4fdd\u969c\u5e7f\u5927\u4eba\u6c11\u7fa4\u4f17\u7528\u836f\u5b89\u5168\u8d77\u5230\u4e86\u79ef\u6781\u4f5c\u7528\u3002\u4ee5\u524d\u901a\u62a5\u6240\u5217\u4fe1\u606f\u5747\u6765\u81ea\u56fd\u5bb6\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u4e2d\u5fc3\u75c5\u4f8b\u62a5\u544a\u6570\u636e\u5e93\uff0c\u4f46\u662f\u968f\u7740\u836f\u54c1\u5e02\u573a\u7684\u5168\u7403\u5316\uff0c\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u4e5f\u8d8b\u4e8e\u56fd\u9645\u5316\uff0c\u5176\u4ed6\u56fd\u5bb6\u7684\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u4fe1\u606f\u5bf9\u4fdd\u969c\u6211\u56fd\u516c\u4f17\u7528\u836f\u5b89\u5168\u4e5f\u5177\u6709\u975e\u5e38\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u4e5f\u662f\u6211\u56fd\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u7684\u91cd\u8981\u5185\u5bb9\u4e4b\u4e00\u3002\u56e0\u6b64\uff0c\u901a\u8fc7\u4fe1\u606f\u901a\u62a5\u7684\u65b9\u5f0f\u53ca\u65f6\u53d1\u5e03\u836f\u54c1\u5728\u5168\u7403\u7684\u6700\u65b0\u5b89\u5168\u6027\u4fe1\u606f\uff0c\u4e5f\u5177\u6709\u79ef\u6781\u4f5c\u7528\u3002\u4e3a\u6b64\uff0c\u6211\u4eec\u5728\u539f\u6709\u901a\u62a5\u4e2d\u589e\u8bbe\u56fd\u5916\u4fe1\u606f\u7248\uff0c\u672a\u6765\u5c06\u6839\u636e\u76d1\u6d4b\u60c5\u51b5\uff0c\u4e0d\u5b9a\u671f\u53d1\u5e03\u56fd\u5916\u76d1\u7ba1\u6280\u672f\u4fe1\u606f\u3002<\/span><\/span><\/span>\n<\/p>\n

\n\t  \u300a\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u4fe1\u606f\u901a\u62a5\u300b\u56fd\u5916\u4fe1\u606f\u7248\u5c06\u4ecb\u7ecd\u56fd\u5916\u5176\u4ed6\u76d1\u7ba1\u90e8\u95e8\u786e\u8ba4\u7684\u6700\u65b0\u5b89\u5168\u6027\u4fe1\u606f\uff0c\u5206\u6790\u5b89\u5168\u6027\u4fe1\u606f\u53d1\u5e03\u7684\u80cc\u666f\u53ca\u76f8\u5173\u6280\u672f\u8d44\u6599\uff0c\u540c\u65f6\u53c2\u8003\u8be5\u836f\u54c1\u5728\u6211\u56fd\u4e34\u5e8a\u4f7f\u7528\u60c5\u51b5\uff0c\u8bc4\u4f30\u5176\u5728\u6211\u56fd\u7684\u98ce\u9669<\/span>\/\u6548\u76ca\u3002\u53d1\u5e03\u300a\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u4fe1\u606f\u901a\u62a5\u300b\u56fd\u5916\u4fe1\u606f\u7248\u65e8\u5728\u8ba9\u5e7f\u5927\u4eba\u6c11\u7fa4\u4f17\uff0c\u5c24\u5176\u662f\u533b\u52a1\u5de5\u4f5c\u8005\uff0c\u5168\u9762\u4e86\u89e3\u548c\u638c\u63e1\u6700\u65b0\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u4fe1\u606f\uff0c\u964d\u4f4e\u6216\u5c3d\u91cf\u907f\u514d\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u7684\u91cd\u590d\u53d1\u751f\uff0c\u4ece\u800c\u4e3a\u4fdd\u969c\u516c\u4f17\u7528\u836f\u7684\u5b89\u5168\u7b51\u8d77\u4e00\u9053\u6709\u6548\u5c4f\u969c\u3002<\/span>
\n<\/span>     <\/span> <\/span>\u8b66\u60d5\u542b\u9486\u78c1\u5171\u632f\u9020\u5f71\u5242\u5f15\u8d77\u7684\u80be\u6e90\u6027\u7cfb\u7edf\u7ea4\u7ef4\u5316<\/span><\/span><\/b><\/span>\n<\/p>\n

\n\t  \u4e00\u3001\u80cc\u666f<\/span><\/span>
\n<\/span>  \u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08<\/span>FDA\uff09\u4e8e2007\u5e745\u6708\u5728\u7f51\u7ad9\u4e0a\u53d1\u51fa\u901a\u544a\uff0c\u8981\u6c42\u4f01\u4e1a\u5bf9\u6240\u6709\u542b\u9486\u78c1\u5171\u632f\u6210\u50cf\uff08MRI\uff09\u9020\u5f71\u5242\uff08\u4ee5\u4e0b\u7b80\u79f0\u542b\u9486\u9020\u5f71\u5242\uff09\u52a0\u5165\u4e00\u4e2a\u65b0\u7684\u9ed1\u6846\u8b66\u544a\u3002\u8b66\u544a\u6709\u4e25\u91cd\u80be\u529f\u80fd\u4e0d\u5168\u7684\u60a3\u8005\u4f7f\u7528\u542b\u9486\u9020\u5f71\u5242\u6709\u53d1\u751f\u80be\u6e90\u6027\u7cfb\u7edf\u7ea4\u7ef4\u5316\uff08Nephrogenic Systemic Fibrosis\uff0cNSF\uff09\u7684\u98ce\u9669\uff0c\u6b64\u5916\uff0c\u8fd8\u8b66\u544a\u8981\u8fdb\u884c\u809d\u79fb\u690d\u6216\u521a\u521a\u5b8c\u6210\u809d\u79fb\u690d\u7684\u60a3\u8005\uff0c\u6216\u6709\u6162\u6027\u809d\u75c5\u7684\u60a3\u8005\uff0c\u5982\u679c\u4ed6\u4eec\u5b58\u5728\u4efb\u4f55\u7a0b\u5ea6\u7684\u80be\u529f\u80fd\u4e0d\u5168\u4e5f\u4f1a\u53d1\u751fNSF\u3002<\/span>
\n<\/span>  \u542b\u9486\u9020\u5f71\u5242\u53ef\u80fd\u8bf1\u53d1<\/span>NSF\u4e0d\u662f\u6700\u8fd1\u624d\u53d1\u73b0\u7684\u3002\u65e9\u57282006\u5e741\u6708\uff0c\u5965\u5730\u5229\u4e00\u9879\u7814\u7a76\u4e2d\u62a5\u90535\u540dNSF\u60a3\u8005\u53ef\u80fd\u4e0e\u4f7f\u7528\u8fc7\u542b\u9486\u9020\u5f71\u5242\u76f8\u5173[1]\u3002\u968f\u540e\u4e39\u9ea6\u533b\u836f\u7ba1\u7406\u5c40\u4e8e2006\u5e745\u6708\u62a5\u544a\u4e8625\u4f8b\u4f7f\u7528\u542b\u9486\u9020\u5f71\u5242\u540e\u53d1\u751fNSF\u7684\u75c5\u4f8b\uff0c\u5176\u4e2d20\u4f8b\u53d1\u751f\u5728\u4e39\u9ea6\uff0c5\u4f8b\u53d1\u751f\u5728\u5965\u5730\u5229\uff08\u89c1\u4e0a\uff09\u3002\u540c\u5e746\u6708\u7f8e\u56fd\u4e5f\u901a\u544a\u4e86\u6b64\u4fe1\u606f\u3002\u968f\u7740\u4e0e\u542b\u9486\u9020\u5f71\u5242\u6709\u5173\u7684NSF\u75c5\u4f8b\u62a5\u544a\u9010\u6e10\u589e\u591a\uff0c\u591a\u9879\u76f8\u5173\u7814\u7a76\u7684\u9646\u7eed\u53d1\u8868\uff0c\u7f8e\u56fdFDA\u4e8e2006\u5e7412\u6708\u66f4\u65b0\u4e86\u542b\u9486\u9020\u5f71\u5242\u53ef\u80fd\u4f1a\u8bf1\u53d1NSF\u7684\u4fe1\u606f\uff0c\u8ba4\u4e3a\u542b\u9486\u9020\u5f71\u5242\u4e0eNSF\u6709\u4e00\u5b9a\u7684\u76f8\u5173\u6027\u3002\u82f1\u56fd\u7b49\u6b27\u76df\u56fd\u5bb6\u4e8e2007\u5e742\u6708\u8b66\u544a\u4e86\u542b\u9486\u9020\u5f71\u5242\u53ef\u80fd\u5f15\u8d77NSF\u7684\u98ce\u9669\uff0c\u5e76\u4fee\u6539\u4e86\u542b\u9486\u9020\u5f71\u5242\u7684\u8bf4\u660e\u4e66\u3002<\/span>
\n<\/span>  \u81ea<\/span>2006\u5e74\u62a5\u9053\u542b\u9486\u9020\u5f71\u5242\u53ef\u80fd\u8bf1\u53d1NSF\u4ee5\u6765\uff0c\u56fd\u5bb6\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u4e2d\u5fc3\u4e00\u76f4\u5bf9\u542b\u9486\u9020\u5f71\u5242\u5f15\u8d77NSF\u7684\u98ce\u9669\u4fdd\u6301\u9ad8\u5ea6\u5173\u6ce8\uff0c\u53ca\u65f6\u8ddf\u8e2a\u56fd\u5916\u6700\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u606f\uff0c\u5e76\u5728\u4e2d\u5fc3\u7f51\u7ad9\uff08www.cdr.gov.cn\uff09\u548c\u300a\u4e2d\u56fd\u836f\u7269\u8b66\u6212\u300b\u6742\u5fd7\u7b49\u8f7d\u4f53\u4e2d\u520a\u8f7d\u4e86\u76f8\u5173\u4fe1\u606f\u53ca\u76f8\u5173\u7814\u7a76\uff0c\u540c\u65f6\u5bc6\u5207\u5173\u6ce8\u6211\u56fd\u542b\u9486\u9020\u5f71\u5242\u7684\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u60c5\u51b5\uff0c\u867d\u7136\u6211\u56fd\u76ee\u524d\u5c1a\u672a\u53d1\u73b0\u542b\u9486\u9020\u5f71\u5242\u8bf1\u53d1NSF\u7684\u62a5\u544a\uff0c\u4f46\u662f\u4e3a\u4e86\u5e7f\u5927\u533b\u62a4\u4eba\u5458\u548c\u60a3\u8005\u53ca\u65f6\u4e86\u89e3\u542b\u9486\u9020\u5f71\u5242\u53ef\u80fd\u8bf1\u53d1NSF\u7684\u98ce\u9669\uff0c\u4fdd\u969c\u4e34\u5e8a\u7528\u836f\u5b89\u5168\uff0c\u56fd\u5bb6\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u4e2d\u5fc3\u7279\u901a\u62a5\u6b64\u5b89\u5168\u4fe1\u606f\u3002<\/span><\/span>\n<\/p>\n

\n\t  \u4e8c\u3001\u4ea7\u54c1\u57fa\u672c\u60c5\u51b5<\/span><\/span>
\n<\/span>  \u542b\u9486\u9020\u5f71\u5242\u7528\u4ee5\u63d0\u9ad8\u56fe\u50cf\u7684\u5bf9\u6bd4\u5ea6\uff0c\u4f7f\u8eab\u4f53\u5404\u90e8\u5206\u7684\u5f02\u5e38\u7ec4\u7ec7\u6216\u60a3\u5904\u663e\u50cf\u3002\u9759\u8109\u6ce8\u5c04\u540e\uff0c\u4e3b\u8981\u7528\u4e8e\u5934\u90e8\u3001\u810a\u9ad3\u548c\u8eab\u4f53\u7b49\u4e00\u822c<\/span>MRI\u9020\u5f71\u3002\u6e38\u79bb\u7684\u9486\u5177\u6709\u9ad8\u6bd2\u6027\uff0c\u5728\u4f53\u5185\u5206\u5e03\u4e8e\u9aa8\u9abc\u548c\u809d\u810f\uff0c\u5e76\u53ef\u8fc5\u901f\u5bfc\u81f4\u809d\u810f\u574f\u6b7b\u3002\u6240\u6709\u7684\u542b\u9486\u9020\u5f71\u5242\u90fd\u662f\u87af\u5408\u7269\uff0c\u87af\u5408\u540e\u80fd\u6539\u53d8\u5176\u5728\u4f53\u5185\u7684\u5206\u5e03\u4ee5\u786e\u4fdd\u56fe\u50cf\u5bf9\u6bd4\u5f3a\u5ea6\uff0c\u540c\u65f6\u6539\u5584\u5176\u6bd2\u526f\u4f5c\u7528\u3002<\/span>
\n<\/span>  \u4e0e<\/span>X\u5c04\u7ebf\u589e\u5f3a\u5242\u4e0d\u540c\uff0c\u9486\u87af\u5408\u7269\u5bf9\u80be\u810f\u6ca1\u6709\u6bd2\u6027\u3002\u56e0\u6b64\uff0c\u8fd1\u5e74\u6765\u5bf9\u4e25\u91cd\u80be\u635f\u4f24\u6216\u66fe\u5bf9\u542b\u7898\u9020\u5f71\u5242\u4e25\u91cd\u8fc7\u654f\u7684\u60a3\u8005\uff0c\u63a8\u8350\u4f7f\u7528\u542b\u9486\u9020\u5f71\u5242\u6765\u66ff\u4ee3\u4f20\u7edf\u7684\u653e\u5c04\u6210\u50cf\u7528\u9020\u5f71\u5242\u3002<\/span>
\n<\/span>  \u5728\u6211\u56fd\uff0c\u542b\u9486\u9020\u5f71\u5242\u9486\u55b7\u9178\u8461\u80fa\u6ce8\u5c04\u6db2\uff08\u5546\u54c1\u540d\uff1a\u9a6c\u6839\u7ef4\u663e\uff09\u9996\u5148\u4e8e<\/span>1988\u5e74\u83b7\u5f97\u8fdb\u53e3\u6279\u51c6\uff0c\u76ee\u524d\u6211\u56fd\u4e0a\u5e02\u7684\u542b\u9486\u7c7b\u9020\u5f71\u5242\u6709\u9486\u8d1d\u8461\u80fa\u6ce8\u5c04\u6db2\uff08\u5546\u54c1\u540d\uff1a\u83ab\u8fea\u53f8\uff09\u3001\u9486\u53cc\u80fa\u6ce8\u5c04\u6db2\uff08\u5546\u54c1\u540d\uff1a\u6b27\u4e43\u5f71\uff09\u3001\u9486\u55b7\u9178\u8461\u80fa\u6ce8\u5c04\u6db2\u548c\u9486\u7279\u9178\u8461\u80fa\u6ce8\u5c04\u6db2\uff08\u5546\u54c1\u540d\uff1a\u591a\u5b83\u7075\uff09\u3002<\/span><\/span>\n<\/p>\n

\n\t  \u4e09\u3001\u80be\u6e90\u6027\u7ea4\u7ef4\u5316\u76ae\u80a4\u75c5<\/span>\/\u80be\u6e90\u6027\u7cfb\u7edf\u7ea4\u7ef4\u5316(NFD\/NSF)<\/span>
\n<\/span>  <\/span>1997\u5e74\uff0c\u80be\u6e90\u6027\u7ea4\u7ef4\u5316\u76ae\u80a4\u75c5\uff08Nephrogenic Fibrosing Dermopa\uff0dthy, NFD\uff09\u9996\u6b21\u5728\u7f8e\u56fd\u88ab\u53d1\u73b0\uff0c\u4e8e2000\u5e74\u9996\u6b21\u5728\u6742\u5fd7\u4e0a\u516c\u5f00\u53d1\u8868[2]\u3002NFD\u4f5c\u4e3a\u4e00\u79cd\u7279\u53d1\u6027\u76ae\u80a4\u75c5\uff0c\u5176\u4e3b\u8981\u7279\u5f81\u4e3a\uff1a\u56db\u80a2\u76ae\u80a4\u53d8\u539a\u53d8\u786c\uff0c\u6709\u65f6\u4f1a\u53d1\u751f\u5728\u8eaf\u5e72\u90e8\uff0c\u540c\u65f6\u4f34\u6709\u76ae\u80a4\u7ea4\u7ef4\u6bcd\u7ec6\u80de\u6837\u7ec6\u80de\u7684\u589e\u751f\u3001\u80f6\u539f\u8d28\u91cd\u7ec4\u53ca\u7c98\u86cb\u767d\u6c89\u79ef\u3002<\/span>
\n<\/span>  <\/span>NFD\u8f83NSF\u5177\u6709\u66f4\u660e\u663e\u548c\u53ef\u89c1\u7684\u76ae\u80a4\u75c5\u53d8\u7279\u5f81\uff0cNSF\u6d89\u53ca\u5230\u80ba\u3001\u809d\u3001\u808c\u8089\u548c\u5fc3\u810f\u7b49\u5668\u5b98[3]\u3002\u56fd\u9645\u80be\u6e90\u6027\u7ea4\u7ef4\u5316\u76ae\u80a4\u75c5\u7814\u7a76\u4e2d\u5fc3\uff08http:\/\/www.icnfdr.org\uff09\u8ba4\u4e3a\uff0cNSF\u8fd9\u4e00\u672f\u8bed\u6bd4NFD\u66f4\u786e\u5207\uff0c\u5b83\u80fd\u66f4\u51c6\u786e\u5730\u53cd\u5e94\u76ee\u524d\u4eba\u4eec\u5bf9\u6b64\u75be\u75c5\u7684\u7406\u89e3\u3002\u56e0\u6b64\uff0c\u5728\u672c\u901a\u62a5\u4e2d\u7528NSF\u6765\u8868\u793aNFD\u548cNSF\u3002<\/span>
\n<\/span>  <\/span>NSF\u4ec5\u53d1\u751f\u5728\u80be\u529f\u80fd\u635f\u5bb3\u7684\u60a3\u8005\u8eab\u4e0a\u3002NSF\u7684\u53d1\u75c5\u65f6\u95f4\u4e3a\u51e0\u5929\u5230\u51e0\u4e2a\u661f\u671f\u3002\u76ae\u80a4\u53d8\u5316\u9996\u5148\u662f\u53d1\u7ea2\u6216\u53d1\u9ed1\u3001\u51fa\u73b0\u4e18\u75b9\u6591\u5757\uff0c\u968f\u540e\u76ae\u80a4\u9ebb\u6728\uff0c\u8868\u76ae\u5448\u73b0\u6854\u9ec4\u8272\u6761\u5f62\u7ea4\u7ef4\u72b6\u3002\u75be\u75c5\u8bca\u65ad\u6839\u636e\u76ae\u80a4\u6d3b\u4f53\u7ec4\u7ec7\u68c0\u67e5\u7684\u7279\u5b9a\u7ec4\u7ec7\u5b66\u75c5\u7406\u7279\u5f81\u6765\u786e\u5b9a\uff1a\u80f6\u539f\u675f\u589e\u539a\u4e14\u5468\u56f4\u51fa\u73b0\u88c2\u7f1d\uff0c\u7c98\u86cb\u767d\u6c89\u79ef\uff0c\u7ea4\u7ef4\u6bcd\u7ec6\u80de\u6837\u7ec6\u80de\u548c\u5f39\u6027\u7ea4\u7ef4\u589e\u751f\u800c\u65e0\u53d1\u708e\u75c7\u72b6[4\u30015]\u3002<\/span>
\n<\/span>  \u76ae\u80a4\u635f\u5bb3\u4e00\u822c\u53d1\u751f\u5728\u8e1d\u5173\u8282\u81f3\u5927\u817f\u4e4b\u95f4\uff0c\u5448\u5bf9\u79f0\u72b6\u3002\u75be\u75c5\u540e\u671f\uff0c\u635f\u5bb3\u90e8\u4f4d\u4f1a\u6269\u5c55\u5230\u8155\u5173\u8282\u548c\u4e0a\u81c2\u4e4b\u95f4\u3002\u75c5\u4eba\u611f\u5230\u60a3\u90e8\u70e7\u707c\u3001\u7619\u75d2\u6216\u5267\u70c8\u523a\u75db\uff0c\u4e5f\u53ef\u80fd\u51fa\u73b0\u624b\u811a\u6d6e\u80bf\u5e76\u5448\u6c34\u6ce1\u72b6\u3002\u53e6\u5916\uff0c\u6709\u4e9b\u60a3\u8005\u773c\u775b\u6216\u9644\u8fd1\u51fa\u73b0\u9ec4\u8272\u4e18\u75b9\u3001\u6591\u5757\uff1b\u4e5f\u66fe\u6709\u75c5\u4f8b\u5728\u76ae\u80a4\u635f\u5bb3\u524d\u51fa\u73b0\u4e0d\u660e\u539f\u56e0\u8840\u538b\u5feb\u901f\u6ce2\u52a8\u7684\u60c5\u51b5\u3002<\/span><\/span>
\n<\/span>  \u8bb8\u591a\u60a3\u8005\u76ae\u80a4\u589e\u539a\u963b\u788d\u4e86\u5173\u8282\u7684\u5f2f\u66f2\u548c\u4f38\u5c55\uff0c\u5bfc\u81f4\u631b\u7f29\u53d8\u5f62\uff0c\u4e25\u91cd\u7684\u60a3\u8005\u6709\u53ef\u80fd\u4e0d\u80fd\u884c\u8d70\uff0c\u751a\u81f3\u624b\u81c2\u3001\u624b\u90e8\u3001\u817f\u548c\u811a\u5173\u8282\u4e0d\u80fd\u6d3b\u52a8\u3002\u60a3\u8005\u4e00\u822c\u5747\u5448\u73b0\u808c\u8089\u865a\u5f31\u7684\u75c7\u72b6\u3002<\/span>X\u5c04\u7ebf\u68c0\u67e5\u663e\u793a\u8f6f\u7ec4\u7ec7\u9499\u5316\uff0c\u9acb\u9aa8\u3001\u808b\u9aa8\u51fa\u73b0\u6df1\u90e8\u9aa8\u75db\u3002<\/span>
\n<\/span>  \u5927\u7ea6\u6709<\/span>5%\u7684\u60a3\u8005\u5448\u73b0\u51fa\u5feb\u901f\u8fdb\u5c55\u7684\u4e25\u91cd\u53d1\u75c5\u8fc7\u7a0b\u3002NSF\u5f15\u8d77\u7684\u8eab\u4f53\u5668\u5b98\u7ea4\u7ef4\u5316\uff08\u635f\u4f24\u673a\u4f53\u6b63\u5e38\u751f\u7406\u529f\u80fd\uff09\u53ef\u80fd\u4f1a\u5bfc\u81f4\u6b7b\u4ea1\uff0c\u547c\u5438\u6291\u5236\u6216\u884c\u52a8\u969c\u788d\uff08\u6613\u5f15\u8d77\u610f\u5916\u6454\u4f24\uff0c\u800c\u5bfc\u81f4\u9aa8\u6298\uff09\u6240\u81f4\u5e76\u53d1\u75c7\u4f7f\u75c5\u60c5\u8fdb\u4e00\u6b65\u6076\u5316\u3002<\/span>
\n<\/span>  \u76ee\u524d\uff0c\u5bf9<\/span>NSF\u5c1a\u65e0\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u7269\u7406\u6cbb\u7597\u6216\u5c40\u90e8\u3001\u7cfb\u7edf\u7c7b\u56fa\u9187\u836f\u7269\u7597\u6cd5\u90fd\u5177\u6709\u4e0d\u786e\u5b9a\u7684\u7597\u6548\u3002\u514d\u75ab\u6291\u5236\u7597\u6cd5\u662f\u65e0\u6548\u7684[6]\u3002\u8840\u6d46\u53bb\u9664\u6cd5[7]\u3001\u5149\u91cf\u5b50\u7597\u6cd5[8]\u548c\u9547\u9759\u5242[9]\u5bf9\u67d0\u4e9b\u60a3\u8005\u7684\u75c7\u72b6\u6709\u4e9b\u6539\u5584\u3002\u6709\u4e9b\u60a3\u8005\u5728\u81ea\u7136\u6761\u4ef6\u6216\u5728\u80be\u79fb\u690d\u6062\u590d\u6b63\u5e38\u80be\u529f\u80fd\u540e\u75c7\u72b6\u5f97\u5230\u6539\u5584[10]\u3002<\/span><\/span>\n<\/p>\n

\n\t  \u56db\u3001\u542b\u9486\u9020\u5f71\u5242\u5f15\u8d77<\/span>NSF\/NFD\u7684\u98ce\u9669\u5206\u6790<\/span>
\n<\/span>  \u9486\u53cc\u80fa\uff08\u5546\u54c1\u540d\uff1a\u6b27\u4e43\u5f71\uff09\u662f\u7b2c\u4e00\u4e2a\u62a5\u9053\u4e0e<\/span>NSF\u6709\u5173\u7684\u542b\u9486\u9020\u5f71\u5242\u3002\u76ee\u524d\u5168\u7403\u6709\u5173\u542b\u9486\u9020\u5f71\u5242\u5f15\u8d77NSF\u75c5\u4f8b\u62a5\u544a\u6709200\u591a\u4f8b\uff0c\u5176\u4e2d\u6b27\u4e43\u5f71\uff1a180\u4f8b\uff1b\u9a6c\u6839\u7ef4\u663e\uff1a78\u4f8b\uff1b\u9486\u6c1f\u585e\u80fa\uff08optiMARK\uff09\uff1a2\u4f8b\uff1b\u83ab\u8fea\u65af\uff1a1\u4f8b\uff08\u8be5\u60a3\u8005\u4e5f\u4f7f\u7528\u8fc7\u6b27\u4e43\u5f71\uff09\uff08\u82f1\u56fd2007\u5e746\u6708\u548c\u7f8e\u56fd2007\u5e743\u6708\u516c\u5e03\u6570\u636e\uff09\uff0c\u5176\u4ed6\u542b\u9486\u9020\u5f71\u5242\u8fd8\u672a\u6536\u5230\u7c7b\u4f3c\u7684\u62a5\u544a\u3002<\/span>
\n<\/span>  <\/span>2006\u5e741\u6708\uff0c\u4e00\u9879\u5965\u5730\u5229\u7684\u7814\u7a76\u8ba4\u4e3a\u542b\u9486\u9020\u5f71\u5242\u53ef\u80fd\u662f\u8bf1\u53d1NSF\u7684\u56e0\u7d20[1]\u30029\u4f8b\u91cd\u75c7\u80be\u75c5\u60a3\u8005\u4e2d\u67095\u4f8b\uff08\u5e73\u5747\u5e74\u9f8458\u5c81\uff09\u5728\u4f7f\u7528\u542b\u9486\u9020\u5f71\u5242\u8fdb\u884c\u78c1\u5171\u632f\u8840\u7ba1\u9020\u5f71\u540e2\uff5e4\u5468\u60a3\u4e0a\u4e86NSF\u3002\u8fd95\u4f8b\u60a3\u8005\u5f00\u59cb\u8868\u73b0\u4e3a\u4e0b\u80a2\u548c\u8db3\u90e8\u76ae\u80a4\u53d8\u539a\u786c\u7ed3\uff0c\u7136\u540e\u8513\u5ef6\u81f3\u8eaf\u5e72\u548c\u8eab\u4f53\u4e0a\u90e8\u3002NSF\u60a3\u8005\u4e0e\u5176\u4ed6\u60a3\u8005\u76f8\u6bd4\u5177\u6709\u66f4\u957f\u7684\u8840\u6db2\u900f\u6790\u53f2\uff0c\u4f46\u5e74\u9f84\u3001\u6027\u522b\u3001\u7528\u836f\u3001\u6f5c\u5728\u80be\u75c5\u3001\u900f\u6790\u9636\u6bb5\u6216\u5e76\u5b58\u75be\u75c5\u65b9\u9762\u672a\u8868\u73b0\u51fa\u5dee\u5f02\u3002<\/span>
\n<\/span>  \u4e00\u9879\u6765\u81ea\u4e39\u9ea6\u7684\u5927\u578b\u7814\u7a76\u4e5f\u663e\u793a\u542b\u9486\u9020\u5f71\u5242\u4e0e<\/span>NSF\u7684\u53d1\u751f\u76f8\u5173[11]\u3002\u57282005\u5e748\u6708\u81f32006\u5e745\u6708\u671f\u95f4\uff0c\u54e5\u672c\u54c8\u6839\u7684\u80be\u75c5\u4e2d\u5fc3\u56de\u987e\u5206\u6790\u4e86\u6240\u6709NSF\u7684\u75c5\u4f8b\u540e\u53d1\u73b0\uff0c\u6240\u670913\u4f8b\u4e25\u91cd\u80be\u75c5\u60a3\u8005\uff08\u5e73\u5747\u5e74\u9f8450\u5c81\uff09\u5728\u7b2c\u4e00\u6b21\u51fa\u73b0NSF\u7684\u75c7\u72b6\u524d\u5747\u4f7f\u7528\u8fc7\u9486\u53cc\u80fa\uff0c7\u4f8b\u53d1\u5c55\u6210\u4e25\u91cd\u6b8b\u75be\uff08\u5176\u4e2d1\u4f8b\u5728\u4f7f\u7528\u542b\u9486\u9020\u5f71\u5242\u540e21\u4e2a\u6708\u6b7b\u4ea1\uff09\uff0c\u5176\u4f59\u76846\u4f8b\u6ca1\u6709\u4ea7\u751f\u4e25\u91cd\u7684\u5f71\u54cd\u3002\u81ea2006\u5e743\u6708\u8be5\u4e2d\u5fc3\u505c\u7528\u9486\u53cc\u80fa\u540e\uff0c\u672a\u518d\u53d1\u73b0NSF\u75c5\u4f8b\u3002<\/span>
\n<\/span>  <\/span>Broome\u7b49\u4eba\u7684\u7814\u7a76\u7ed3\u679c\u8868\u660e\u80be\u900f\u6790\u60a3\u8005\u4f7f\u7528\u9486\u53cc\u80fa\u540e\u6709\u53d1\u751fNSF\u7684\u98ce\u9669[12]\u3002\u7814\u7a76\u4e2d\u4f7f\u7528\u8fc7\u9486\u53cc\u80fa\u7684301\u4f8b\u80be\u900f\u6790\u60a3\u8005\u4e2d\u670912\u4f8b\u5df2\u786e\u8bca\u60a3\u6709NSF\uff0c\u800c\u672a\u4f7f\u7528\u8fc7\u9486\u53cc\u80fa\u7684258\u4f8b\u4e2d\u672a\u53d1\u73b0NSF\u75c5\u4f8b\uff0c\u4f7f\u7528\u9486\u53cc\u80fa\u540e\u53d1\u751fNSF\u7684\u6bd4\u6570\u6bd4\u4e3a22.3[95%\uff0cCI 1.3\uff5e378.9]\u3002\u53e6\u5916\uff0c\u7814\u7a76\u8fd8\u8868\u660e\u5f53\u9486\u53cc\u80fa\u4f7f\u7528\u5242\u91cf\u4e3a\u63a8\u8350\u5242\u91cf\u76842\u500d\u65f6\uff0c\u5176\u98ce\u9669\u5ea6\u5c06\u660e\u663e\u589e\u52a0\u3002<\/span>
\n<\/span>  \u5728\u53e6\u4e00\u9879\u7814\u7a76\u4e2d\uff0c<\/span>254\u4f8b\u80be\u529f\u80fd\u4e0d\u5168\u7684\u60a3\u8005\u5728\u4f7f\u7528\u542b\u9486\u9020\u5f71\u5242\u540e\u67097\u4f8b\u53d1\u751f\u4e86NSF\uff0c\u53d1\u751f\u7387\u4e3a3%[13]\u3002\u5728Broome\u7684\u7814\u7a76\u4e2d\uff0c\u900f\u6790\u60a3\u8005\u4f7f\u7528\u542b\u9486\u9020\u5f71\u5242\u540eNSF\u7684\u53d1\u751f\u7387\u4e3a4\uff05[12]\u3002\u63a5\u53d7\u8fc7\u809d\u79fb\u690d\u624b\u672f\u7684\u60a3\u8005\u4e5f\u62a5\u9053\u5b58\u5728NSF\u53d1\u751f\u7684\u98ce\u9669[14,15]\u3002<\/span>
\n<\/span>  \u7efc\u4e0a\u6240\u8ff0\uff0c\u542b\u9486\u9020\u5f71\u5242\u5b58\u5728\u8bf1\u53d1<\/span>NSF\/NFD\u7684\u98ce\u9669\u3002<\/span><\/span>\n<\/p>\n

\n\t  \u4e94\u3001\u542b\u9486\u9020\u5f71\u5242\u8bf1\u53d1<\/span>NSF\u7684\u673a\u7406<\/span>
\n<\/span>  \u542b\u9486\u9020\u5f71\u5242\u5f15\u8d77<\/span>NSF\u7684\u673a\u5236\u76ee\u524d\u8fd8\u5728\u7814\u7a76\u9636\u6bb5\u3002\u76ee\u524d\u8ba4\u4e3a\uff1a\u80be\u635f\u4f24\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u56e0\u7d20\uff0c\u56e0\u4e3aNSF\u53ea\u53d1\u751f\u5728\u4e25\u91cd\u80be\u529f\u80fd\u4e0d\u5168\u7684\u60a3\u8005\u8eab\u4e0a\uff0c\u4ed6\u4eec\u9700\u8981\u82b1\u8d39\u66f4\u957f\u7684\u65f6\u95f4\u6392\u9664\u4f53\u5185\u7684\u9020\u5f71\u5242\u3002\u5728\u80be\u635f\u5bb3\u60a3\u8005\u4e2d\uff0c \u4e09\u4ef7\u9486\u79bb\u5b50\u53ef\u80fd\u4ece\u9ccc\u5408\u7269\u4e2d\u901a\u8fc7\u673a\u4f53\u5185\u79bb\u5b50\u7684\u91d1\u5c5e\u8f6c\u79fb\u4f5c\u7528\u91ca\u653e\u51fa\u6765\uff0c\u6e38\u79bb\u7684\u9486\u79bb\u5b50\u80fd\u523a\u6fc0\u7ec4\u7ec7\u548c\u5668\u5b98\u53d1\u751f\u7ea4\u7ef4\u5316\uff0c\u4ece\u800c\u5bfc\u81f4NSF\u3002<\/span>
\n<\/span>  \u9486\u5728\u4eba\u4f53\u7ec4\u7ec7\u5185\u6c89\u79ef\u5df2\u5728<\/span>NSF\u60a3\u8005\u7ec4\u7ec7\u4e2d\u5f97\u5230\u6838\u5b9e\u3002High\u7b49\u4eba\u68c0\u6d4b\u4e867\u4f8b\u53d1\u751fNSF\u524d\u4f7f\u7528\u8fc7\u542b\u9486\u9020\u5f71\u5242\u7684\u60a3\u8005\u4f53\u5185\u768413\u4e2a\u7ec4\u7ec7\uff0c\u5176\u4e2d\u67094\u4e2a\u7ec4\u7ec7\u51fa\u73b0\u4e86\u9486\u6c89\u79ef\u73b0\u8c61[16]\u3002\u800c\u4e14\u60a3\u8005\u5728\u4f7f\u7528\u542b\u9486\u9020\u5f71\u524211\u4e2a\u6708\u540e\u4ecd\u80fd\u5728\u5176\u7ec4\u7ec7\u6837\u672c\u4e2d\u68c0\u6d4b\u5230\u9486\uff0c\u800c\u672a\u53d1\u751fNSF\u7684\u60a3\u8005\u7ec4\u7ec7\u6837\u672c\u4e2d\u672a\u68c0\u6d4b\u5230\u9486\u3002Boyd\u7b49\u4eba\u4e5f\u8bc1\u5b9e\u4e86NSF\u60a3\u8005\u4f53\u5185\u9486\u7684\u6c89\u79ef\u73b0\u8c61\uff0c\u53d1\u73b0\u6c89\u79ef\u7684\u53d1\u751f\u4e00\u822c\u6709\u533a\u57df\u6027\u9650\u5236\uff0c\u4e14\u8be5\u533a\u57df\u5185\u4e5f\u51fa\u73b0\u78f7\u9178\u9499\u7684\u6c89\u79ef[17]\u3002\u9486\u5728\u7ec4\u7ec7\u4e2d\u6c89\u79ef\u53ef\u4ee5\u901a\u8fc7\u591a\u79cd\u673a\u5236\u8bf1\u53d1NSF\uff0c\u5982\u5faa\u73af\u6210\u7ea4\u7ef4\u7ec6\u80de\u548c\u8f6c\u5316\u751f\u957f\u56e0\u5b50\u7684\u4ecb\u5165\u7b49[18,19]\u3002<\/span><\/span>\n<\/p>\n

\n\t  \u516d\u3001\u5efa\u8bae<\/span><\/span>
\n<\/span>  \u9274\u4e8e\u542b\u9486\u9020\u5f71\u5242\u5177\u6709\u53ef\u80fd\u8bf1\u53d1<\/span>NSF\u7684\u98ce\u9669\uff0c\u5efa\u8bae\u5e7f\u5927\u533b\u62a4\u4eba\u5458\u4e25\u683c\u6309\u7167\u9002\u5e94\u75c7\u4f7f\u7528\uff0c\u4e0d\u8981\u8d85\u5242\u91cf\u4f7f\u7528\uff0c\u5e76\u5728\u4f7f\u7528\u524d\u5e94\u6ce8\u610f\u60a3\u8005\u80be\u529f\u80fd\u60c5\u51b5\uff0c\u5e76\u4e14\u5e94\u5728\u4f53\u5185\u7684\u9020\u5f71\u5242\u6e05\u9664\u540e\uff0c\u624d\u53ef\u518d\u6b21\u4f7f\u7528\u3002\u4e25\u91cd\u80be\u529f\u80fd\u4e0d\u5168\u7684\u60a3\u8005\u4f7f\u7528\u542b\u9486\u9020\u5f71\u5242\u540e\uff0c\u5e94\u53ca\u65f6\u8fdb\u884c\u8840\u6db2\u900f\u6790\uff0c\u4ee5\u5e2e\u52a9\u60a3\u8005\u5c3d\u5feb\u6392\u51fa\u4f53\u5185\u7684\u9486\uff0c\u51cf\u5c11\u9486\u5728\u60a3\u8005\u4f53\u5185\u505c\u7559\u7684\u65f6\u95f4\u3002<\/span><\/span>\n<\/p>\n

\n\t\u53c2\u8003\u6587\u732e<\/span><\/span>
\n<\/span>  <\/span>1\uff0eGrobner T. Gadolinium-a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? Nephrol Dial Transplant 2006; 21: 1104-08. Erratum 1745.<\/span>
\n<\/span>  <\/span>2\uff0eCowper SE, Robin HS, Steinberg SM, et al. Scleromyxoedema-like cutaneous diseases in renal-dialysis patients. Lancet 2000; 356:1000-01.<\/span>
\n<\/span>  <\/span>3\uff0eDaram SR, Cortese CM, Bastani B. Nephrogenic fibrosing der\uff0dmopathy\/nephrogenic systemic fibrosis: report of a new case with litera\uff0dture review. Am J Kidney Dis 2005; 46:754-59.<\/span>
\n<\/span>  <\/span>4\uff0eCowper SE, Su LD, Bhawan J, et al. Nephrogenic fibrosing der\uff0dmopathy. Am J Dermatopathol 2001; 23: 383-93.<\/span>
\n<\/span>  <\/span>5\uff0eMcNeill AM, Barr RJ. Scleromyxedema-like fibromucinosis in a patient undergoing hemodialysis. Int J Dermatol 2002; 41: 364-67.<\/span>
\n<\/span>  <\/span>6\uff0eGrobner T. Gadolinium-a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? Nephrol Dial Transplant 2006; 21: 1104-08. Erratum 1745.<\/span>
\n<\/span>  <\/span>7\uff0eBaron PW, Cantos K, Hillebrand DJ, Hu KO, et al. Nephrogenic fibrosing dermopathy after liver transplantation successfully treated with plasmapheresis. Am J Dermatopathol; 2003 25: 204-09.<\/span>
\n<\/span>  <\/span>8\uff0eGilliet M, Cozzio A, Burg G, Nestle FO. Successful treatment of three cases of nephrogenic fibrosing dermopathy with extracorporeal pho\uff0dtopheresis. Br J Dermatol 2005; 152: 531-36.<\/span>
\n<\/span>  <\/span>9\uff0eMoschella SL, Kay J, Mackool BT, Liu V. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 35-2004. A 68-year-old man with end stage renal disease and thickening of the skin. N Engl J Med 2004; 351: 2219-27.<\/span>
\n<\/span>  <\/span>10\uff0eCowper SE. Nephrogenic fibrosing dermopathy: the first 6 years. Curr Opin Rheumatol 2003; 15: 785-90.<\/span>
\n<\/span>  <\/span>11\uff0eMarckmann P, Skov L, Rossen K, et al. Nephrogenic systemic fibrosis: suspected causative role of gadodiamide used for contrast-en\uff0dhanced magnetic resonance imaging. J Am Soc Nephrol 2006; 17: 2359-62.<\/span>
\n<\/span>  <\/span>12\uff0eBroome DR, Girguis MS, Baron PW, Cottrell AC, et al. Gadodi\uff0damide-associated nephrogenic systemic fibrosis: why radiologists should be concerned. MR Imaging (In press). AJR Am J Roentgenol 2007; 188: 586-92.<\/span>
\n<\/span>  <\/span>13\uff0eSadowski E, Bennett L, Chang M, Wentland A, et al. Gadolini\uff0dum and Nephrogenic Fibrosing Dermopathy. RSNA 2006; E353B.<\/span>
\n<\/span>  <\/span>14\uff0eBaron PW, Cantos K, Hillebrand DJ, Hu KO, et al. Nephrogenic fibrosing dermopathy after liver transplantation successfully treated with plasmapheresis. Am J Dermatopathol; 2003 25: 204-09.<\/span>
\n<\/span>  <\/span>15\uff0eMaloo M, Abt P, Kashvap R, et al. Nephrogenic systemic fibro\uff0dsis among liver transplant recipients: a single institution experience and topic update. Am J Transplant 2006; 6: 2212-17.<\/span>
\n<\/span>  <\/span>16\uff0eHigh WA, Avers RA, Chandler J, et al. Gadolinium is de\uff0dtectable within the tissue of patients with nephrogenic systemic fibrosis. J Am Acad Dermatol 2007; 56: 21-26.<\/span>
\n<\/span>  <\/span>17\uff0eBoyd AS, Zic JA, Abraham JL. Gadolinium deposition in nephrogenic fibrosing dermopathy. J Am Acad Dermatol 2007; 56: 27-30.<\/span>
\n<\/span>  <\/span>18\uff0eJimenez SA, Artlett CM, Sandorfi N, et al. Dialysis-associated systemic fibrosis (nephrogenic fibrosing dermopathy): study of inflamma\uff0dtory cells and transforming growth factor beta1 expression in affected skin. Arthritis Rheum 2004; 50: 2660-66.<\/span>
\n<\/span>  <\/span>19\uff0eGalan A, Cowper SE, Bucala R. Nephrogenic systemic fibrosis (nephrogenic fibrosing dermopathy). Curr Opin Rheumatol 2006; 18: 614-17.<\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

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