{"id":3920,"date":"2022-04-27T09:00:54","date_gmt":"2022-04-27T01:00:54","guid":{"rendered":"http:\/\/localhost:9966\/?p=3920"},"modified":"2026-06-23T15:47:17","modified_gmt":"2026-06-23T07:47:17","slug":"%e9%a6%96%e9%83%bd%e5%8c%bb%e7%a7%91%e5%a4%a7%e5%ad%a6%e9%99%84%e5%b1%9e%e5%8c%97%e4%ba%ac%e6%9c%9d%e9%98%b3%e5%8c%bb%e9%99%a2","status":"publish","type":"post","link":"https:\/\/www.blpa.com.cn\/?p=3920","title":{"rendered":"\u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u671d\u9633\u533b\u9662"},"content":{"rendered":"

\n\t\"\"\n<\/p>\n

\n\t\n<\/p>\n

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\n\t  \u836f\u4e8b\u90e8\u4e0b\u8bbe\u6709\u529e\u516c\u5ba4\u3001\u95e8\u8bca\u8c03\u5242\u4e2d\u5fc3\u3001\u75c5\u623f\u8c03\u5242\u4e2d\u5fc3\u3001\u836f\u5b66\u7814\u7a76\u4e2d\u5fc3\u3001\u4e34\u5e8a\u836f\u5b66\u4e2d\u5fc3\u3001\u91c7\u8d2d\u4e2d\u5fc3\u5171\u516d\u4e2a\u4e8c\u7ea7\u90e8\u95e8\u3002\u73b0\u6709\u4e3b\u4efb\u836f\u5e08<\/span>1\u4eba\u3001\u526f\u4e3b\u4efb\u836f\u5e086\u4eba\u3001\u4e3b\u7ba1\u836f\u5e0853\u4eba\u3001\u836f\u5e0843\u4eba\u3001\u4e3b\u7ba1\u62a4\u5e087\u4eba\u3001\u62a4\u5e088\u4eba\u3001\u52a9\u7406\u4f1a\u8ba1\u5e081\u4eba\uff0c\u5176\u4e2d\u535a\u58eb\u540e3\u4eba\uff0c\u535a\u58eb8\u4eba\u3001\u7855\u58eb16\u4eba\uff0c\u672c\u79d153\u4eba\u3002<\/span><\/span>\n<\/p>\n

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\n\t  \u95e8\u8bca\u8c03\u5242\u4e2d\u5fc3\u4e0b\u8bbe\u95e8\u8bca\u836f\u623f\u3001\u6025\u8bca\u836f\u623f\u3001\u7279\u9700\u836f\u623f\u3001\u53d1\u70ed\u836f\u623f\u3001\u8349\u836f\u623f\u548c\u714e\u836f\u5ba4\u516d\u4e2a\u90e8\u95e8\u3002\u95e8\u8bca\u8c03\u5242\u4e2d\u5fc3\u4e0d\u65ad\u4f18\u5316\u836f\u4e8b\u670d\u52a1\u5185\u5bb9\uff0c\u62d3\u5c55\u836f\u5b66\u670d\u52a1\u5185\u6db5\uff0c<\/span>\u201c\u60a3\u8005\u6559\u80b2\u5927\u8bb2\u5802\u201d\u3001\u201c\u95e8\u8bca\u836f\u5386\u201d\u3001\u836f\u5e08\u6e29\u99a8\u63d0\u793a\u5361\u7b49\u4e3e\u63aa\uff0c\u9010\u6b65\u5b9e\u73b0\u4e86\u4ee5\u201c\u60a3\u8005\u4e3a\u4e2d\u5fc3\u201d\u7684\u836f\u5b66\u670d\u52a1\u6a21\u5f0f\u8f6c\u6362\u3002\u6309\u7167\u533b\u7ba1\u5c40\u7edf\u4e00\u90e8\u7f72\uff0c\u7528\u836f\u54a8\u8be2\u4e2d\u5fc3\u4e8e4\u6708\u4efd\u6b63\u5f0f\u6302\u724c\u6210\u7acb\uff0c\u7531\u79d1\u4e3b\u4efb\u4eb2\u81ea\u5e26\u961f\uff0c\u7ec4\u5efa\u4e86\u4e00\u652f13\u4eba\u7684\u54a8\u8be2\u836f\u5e08\u56e2\u961f\uff0c\u4f18\u8d28\u3001\u4e13\u4e1a\u7684\u54a8\u8be2\u670d\u52a1\u4f7f\u7528\u836f\u54a8\u8be2\u4e2d\u5fc3\u9010\u6e10\u6210\u4e3a\u4e86\u5ba3\u4f20\u5b89\u5168\u5408\u7406\u7528\u836f\u6587\u5316\u7684\u524d\u6cbf\u9635\u5730\u3002<\/span><\/span>\n<\/p>\n

\n\t  \u75c5\u623f\u8c03\u5242\u4e2d\u5fc3\u4e0b\u8bbe\u9759\u8109\u7528\u836f\u8c03\u914d\u4e2d\u5fc3<\/span>(PIVAS)\u548c\u7247\u5242\u6446\u836f\u5ba4\uff0cPIVAS\u65e5\u5747\u914d\u7f6e\u9759\u8109\u7528\u836f\u7ea62000\u888b\uff0c\u5e74\u914d\u7f6e70\u4e07\u4f59\u888b\u3002\u75c5\u623f\u8c03\u5242\u4e2d\u5fc3\u4e8e2012\u5e74\u5e95\u987a\u5229\u542f\u52a8\u65b0\u578b\u836f\u54c1\u914d\u9001\u6a21\u5f0f\uff0c\u9010\u6e10\u5b9e\u65bd\u4e34\u65f6\u548c\u957f\u671f\u8f93\u6db2\u533b\u5631\u836f\u54c1\u4e0b\u9001\u75c5\u533a\u7684\u5de5\u4f5c\uff0c\u5207\u5b9e\u51cf\u8f7b\u4e86\u4e34\u5e8a\u62a4\u58eb\u7684\u5de5\u4f5c\u91cf\uff0c\u4fdd\u8bc1\u4e86\u6d41\u901a\u73af\u8282\u4e2d\u7684\u836f\u54c1\u8d28\u91cf\uff0c\u4fc3\u8fdb\u4e86\u75c5\u533a\u5408\u7406\u7528\u836f\u5de5\u4f5c\u7684\u5f00\u5c55\uff0c\u63d0\u9ad8\u4e86\u4e34\u5e8a\u4e0e\u60a3\u8005\u7684\u6ee1\u610f\u5ea6\u3002<\/span><\/span>\n<\/p>\n

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\n\t  \u4e34\u5e8a\u836f\u5b66\u4e2d\u5fc3\u5de5\u4f5c\u5305\u62ec\u4e34\u5e8a\u836f\u5e08\u3001\u8840\u836f\u6d53\u5ea6\u76d1\u6d4b\u548c\u836f\u7269\u8b66\u6212\u4e09\u4e2a\u4e3b\u8981\u65b9\u5411\uff0c\u8d1f\u8d23\u5168\u9662\u6297\u83cc\u836f\u7269\u548c\u5408\u7406\u7528\u836f\u7ba1\u7406\uff0c\u5df2\u5efa\u7acb\u4e86\u8f83\u6210\u719f\u7684\u6297\u83cc\u836f\u7269\u548c\u5408\u7406\u7528\u836f\u76d1\u7ba1\u5e73\u53f0\u3002\u914d\u6709<\/span>8\u540d\u4e13\u804c\u4e34\u5e8a\u836f\u5e08\uff0c\u5206\u522b\u6df1\u5165\u547c\u5438\u79d1\u3001SICU\u3001\u9aa8\u79d1\u3001\u80f8\u5916\u79d1\u3001\u8840\u7ba1\u5916\u79d1\u3001\u666e\u5916\u79d1\u3001\u809d\u80c6\u5916\u79d1\u3001\u795e\u7ecf\u5916\u79d1\u3001\u6025\u8bca\u79d1\u3001\u80be\u5185\u79d1\u7b49\u5f00\u5c55\u4e34\u5e8a\u836f\u5b66\u5de5\u4f5c\uff0c\u5b9a\u671f\u53d1\u5e03\u300a\u6297\u83cc\u836f\u7269\u4e34\u5e8a\u836f\u7269\u76d1\u6d4b\u901a\u62a5\u300b\u3001\u300a\u5408\u7406\u7528\u836f\u76d1\u6d4b\u901a\u62a5\u300b\u3002<\/span><\/span>\n<\/p>\n

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\n\t\u79d1\u5ba4\u7279\u8272<\/span><\/span><\/span>\n<\/p>\n

\n\t  <\/span>1. \u7cbe\u51c6\u7528\u836f\u4e13\u5bb6\u95e8\u8bca<\/span><\/b><\/span>\n<\/p>\n

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\n\t<\/span>\n<\/p>\n

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

\n\t\t\t\t\t\t\u76f8\u5173\u836f\u7269<\/span><\/b><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u68c0\u6d4b\u9879\u76ee<\/span><\/b><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u68c0\u6d4b\u610f\u4e49<\/span><\/b><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u5fc3\u8840\u7ba1\u75be\u75c5<\/span><\/span>\n\t\t\t\t\t<\/p>\n

\n\t\t\t\t\t\t\uff08\u5242\u91cf\u9ad8\u4e86\u51fa\u8840\u3001\u6bd2\u6027\u5927\uff1b<\/span><\/span>\n\t\t\t\t\t<\/p>\n

\n\t\t\t\t\t\t\u5242\u91cf\u4f4e\u4e86\u8840\u6813\u3001\u65e0\u6548\uff09<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u6c2f\u5421\u683c\u96f7<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tCYP2C19<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u8c03\u6574\u5242\u91cf\u51cf\u5c11\u51fa\u8840\u6216\u5fc3\u6897\u98ce\u9669<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u534e\u6cd5\u6797<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tCYP2C9<\/span><\/span>\n\t\t\t\t\t<\/p>\n

\n\t\t\t\t\t\tVKORC<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u8c03\u6574\u5242\u91cf\u51cf\u5c11\u51fa\u8840\u548c\u5352\u4e2d\u98ce\u9669<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u785d\u9178\u7518\u6cb9<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tALDH2<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u9884\u6d4b\u7597\u6548\u53ca\u764c\u75c7\u98ce\u9669<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u7f8e\u6258\u6d1b\u5c14<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tCYP2D6<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u8c03\u6574\u5242\u91cf\u3001\u589e\u5f3a\u7597\u6548<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u963f\u6258\u4f10\u4ed6\u6c40<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tSLCO1B1<\/span><\/span>\n\t\t\t\t\t<\/p>\n

\n\t\t\t\t\t\tApoE<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u8c03\u6574\u5242\u91cf\u3001\u964d\u4f4e\u6bd2\u6027<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u666e\u7f57\u5e15\u916e<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tCYP2D6<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u8c03\u6574\u5242\u91cf\u3001\u589e\u5f3a\u7597\u6548<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u6d88\u5316\u7cfb\u7edf\u75be\u75c5<\/span><\/span>\n\t\t\t\t\t<\/p>\n

\n\t\t\t\t\t\t\uff08\u836f\u7269\u65e0\u6548\u751a\u81f3\u6709\u81f4\u764c\u98ce\u9669\uff09<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u5965\u7f8e\u62c9\u5511<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tCYP2C19<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u8c03\u6574\u5242\u91cf\u964d\u4f4e\u81f4\u764c\u98ce\u9669<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u5170\u7d22\u62c9\u5511<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tCYP2C19<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u8c03\u6574\u5242\u91cf\u964d\u4f4e\u81f4\u764c\u98ce\u9669<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u96f7\u8d1d\u62c9\u5511<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tCYP2C19<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u8c03\u6574\u5242\u91cf\u964d\u4f4e\u81f4\u764c\u98ce\u9669<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u6cee\u6258\u62c9\u5511<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tCYP2C19<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u8c03\u6574\u5242\u91cf\u964d\u4f4e\u81f4\u764c\u98ce\u9669<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u80bf\u7624\u76f8\u5173\u75be\u75c5<\/span><\/span>\n\t\t\t\t\t<\/p>\n

\n\t\t\t\t\t\t\uff08\u9776\u5411\u836f\u7269\u5fc5\u987b\u662f\u7a81\u53d8\u60a3\u8005\u624d\u6709\u6548\uff0c\u672a\u7a81\u53d8\u60a3\u8005\u7597\u6548\u4e0d\u4f73\uff1b\u6297\u80bf\u7624\u836f\u7269\u6bd2\u6027\u5927\uff0c\u5e38\u5e38\u90fd\u662f\u56e0\u4e3a\u65e0\u6cd5\u8010\u53d7\u800c\u505c\u836f\uff09<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u4f0a\u7acb\u66ff\u5eb7<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tUGT1A1<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u8c03\u6574\u5408\u7406\u5316\u7597\u65b9\u6848\uff0c\u51cf\u5c11\u6bd2\u526f\u4f5c\u7528<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t5-\u6c1f\u5c3f\u5627\u5576<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tDYPD<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u51cf\u5c11\u6bd2\u526f\u4f5c\u7528\uff0c\u8c03\u6574\u5408\u7406\u5316\u7597\u65b9\u6848<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u5361\u57f9\u4ed6\u6ee8<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tDYPD<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u51cf\u5c11\u6bd2\u526f\u4f5c\u7528\uff0c\u8c03\u6574\u5408\u7406\u5316\u7597\u65b9\u6848<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u94c2\u7c7b\u836f\u7269<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tXRCC1<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u51cf\u5c11\u6bd2\u526f\u4f5c\u7528\uff0c\u8c03\u6574\u5408\u7406\u5316\u7597\u65b9\u6848<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u6765\u66f2\u5511<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tCYP19A1<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u51cf\u5c11\u6bd2\u526f\u4f5c\u7528\uff0c\u8c03\u6574\u5408\u7406\u5316\u7597\u65b9\u6848<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u963f\u90a3\u66f2\u5511<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tCYP19A1<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u51cf\u5c11\u6bd2\u526f\u4f5c\u7528\uff0c\u8c03\u6574\u5408\u7406\u5316\u7597\u65b9\u6848<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u5409\u975e\u66ff\u5c3c<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tEGFR<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u9884\u6d4b\u836f\u7269\u7597\u6548\u548c\u9884\u540e<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u5384\u6d1b\u66ff\u5c3c<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tEGFR<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t \u9884\u6d4b\u836f\u7269\u7597\u6548\u548c\u9884\u540e<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u514d\u75ab\u6291\u5236\u5242<\/span><\/span>\n\t\t\t\t\t<\/p>\n

\n\t\t\t\t\t\t\uff08\u5242\u91cf\u5927\u4e86\u6bd2\u6027\u5927\uff0c<\/span><\/span>\n\t\t\t\t\t<\/p>\n

\n\t\t\t\t\t\t\u5242\u91cf\u4f4e\u4e86\u4ea7\u751f\u6392\u65a5\uff09<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u4ed6\u514b\u83ab\u53f8<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tCYP3A5<\/span><\/span>\n\t\t\t\t\t<\/p>\n

\n\t\t\t\t\t\t\u8840\u836f\u6d53\u5ea6\u76d1\u6d4b<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u8c03\u6574\u5242\u91cf\uff0c\u51cf\u5c11\u6392\u5f02\u6216\u836f\u7269\u6bd2\u6027<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u73af\u5b62\u7d20A<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tCYP3A4<\/span><\/span>\n\t\t\t\t\t<\/p>\n

\n\t\t\t\t\t\t\u8840\u836f\u6d53\u5ea6\u76d1\u6d4b<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u8c03\u6574\u5242\u91cf\uff0c\u51cf\u5c11\u6392\u5f02\u6216\u836f\u7269\u6bd2\u6027<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u7cbe\u795e\u7cfb\u7edf\u75be\u75c5<\/span><\/span>\n\t\t\t\t\t<\/p>\n

\n\t\t\t\t\t\t\uff08\u7597\u6548\u4e0d\u4f73\u6216\u4e0d\u826f\u53cd\u5e94\u8fc7\u5927\u65e0\u6cd5\u8010\u53d7\uff09<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u6c1f\u897f\u6c40<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tCYP2D6<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u8c03\u6574\u5242\u91cf\u589e\u5f3a\u7597\u6548\uff0c\u51cf\u5c11\u4e0d\u826f\u53cd\u5e94<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u5e15\u7f57\u897f\u6c40<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tCYP2D6<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u8c03\u6574\u5242\u91cf\u589e\u5f3a\u7597\u6548\uff0c\u51cf\u5c11\u4e0d\u826f\u53cd\u5e94<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u5229\u57f9\u916e<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tCYP2D6<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u8c03\u6574\u5242\u91cf\u589e\u5f3a\u7597\u6548\uff0c\u51cf\u5c11\u4e0d\u826f\u53cd\u5e94<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u6587\u62c9\u6cd5\u8f9b<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tCYP2D6<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u8c03\u6574\u5242\u91cf\u589e\u5f3a\u7597\u6548\uff0c\u51cf\u5c11\u4e0d\u826f\u53cd\u5e94<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u897f\u915e\u666e\u5170<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tCYP2C19<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u8c03\u6574\u5242\u91cf\u589e\u5f3a\u7597\u6548\uff0c\u51cf\u5c11\u4e0d\u826f\u53cd\u5e94<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u9547\u75db\u836f\u7269<\/span><\/span>\n\t\t\t\t\t<\/p>\n

\n\t\t\t\t\t\t\uff08\u9547\u75db\u6548\u679c\u4e0d\u4f73\u6216\u836f\u7269\u4e2d\u5ea6\uff09<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u53ef\u5f85\u56e0<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tCYP2D6<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u9884\u6d4b\u7597\u6548\uff0c\u9884\u9632\u4e0d\u826f\u53cd\u5e94<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u66f2\u9a6c\u591a<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tCYP2D6<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u9884\u6d4b\u7597\u6548\uff0c\u9884\u9632\u4e0d\u826f\u53cd\u5e94<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u6297\u771f\u83cc\u7c7b\u836f\u7269<\/span><\/span>\n\t\t\t\t\t<\/p>\n

\n\t\t\t\t\t\t\uff08\u6bd2\u6027\u8fc7\u5927\u6216\u7597\u6548\u4e0d\u4f73\uff09<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u4f0f\u7acb\u5eb7\u5511<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tCYP2C19<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u8c03\u6574\u5242\u91cf\u589e\u5f3a\u7597\u6548\uff0c\u51cf\u5c11\u4e0d\u826f\u53cd\u5e94<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\t\t\u6291\u764c\u57fa\u56e0\u68c0\u6d4b<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t—<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\tBRCA1\u30012<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n

\n

\n\t\t\t\t\t\t\u9884\u6d4b\u60a3\u764c\u98ce\u9669\uff0c\u5224\u65ad\u764c\u75c7\u8fdb\u5c55<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\n\t <\/span><\/b>\n<\/p>\n

\n\t<\/span><\/b>\n<\/p>\n

\n\t <\/span><\/b><\/b>\n<\/p>\n

\n\t        2. \u6cbb\u7597\u836f\u7269\u76d1\u6d4b(\u7b80\u79f0TDM)<\/strong><\/span><\/span>\n<\/p>\n

\n\t  \u4ed6\u514b\u83ab\u53f8<\/span>(FK506)\u3001\u73af\u5b62\u7d20A\u3001\u96f7\u5e15\u9709\u7d20\u3001\u5730\u9ad8\u8f9b\u3001\u4e07\u53e4\u9709\u7d20\u3001\u7532\u6c28\u558b\u5464\u3001\u5361\u9a6c\u897f\u5e73\u3001\u4e19\u620a\u9178\u3001\u82ef\u59a5\u82f1\u7b499\u4e2a\u54c1\u79cd\u7684\u8840\u836f\u6d53\u5ea6\u76d1\u6d4b\u3002\u91c7\u7528\u65b0\u578b\u6db2\u76f8\u8272\u8c31\u8d28\u8c31\u6280\u672f\u8fdb\u884c\u51c6\u786e\u5b9a\u91cf\uff0c\u7cbe\u51c6\u5ea6\u3001\u68c0\u6d4b\u901f\u5ea6\u5168\u9762\u63d0\u9ad8\uff0c\u5e74\u68c0\u6d4b\u91cf>10000\u4f8b\uff0c\u4e3a\u60a3\u8005\u63d0\u4f9b\u826f\u597d\u7684\u7528\u836f\u65b9\u6848\u3002<\/span><\/span>\n<\/p>\n

\n\t <\/span>\n<\/p>\n

\n\t     <\/span>3. \u836f\u7269\u4e2d\u6bd2\u5feb\u901f\u7b5b\u67e5<\/span><\/b><\/span>\n<\/p>\n

\n\t  \u5df2\u5efa\u7acb\u4e86\u8f83\u5148\u8fdb\u7684<\/span>LC-MS\/MS\u5feb\u901f\u9ad8\u901a\u91cf\u7b5b\u67e5\u4f53\u5185300\u79cd\u4e2d\u6bd2\u836f\u7269\u7684\u65b9\u6cd5\uff0c\u8fd0\u7528\u8d28\u8c31\u4e2d\u76f8\u5173\u4fe1\u606f\u626b\u63cf\u6a21\u5f0f(Information Dependent Acquisition, IDA)\uff0c\u65b9\u6cd5\u7b80\u6d01\u3001\u7075\u654f\u3001\u51c6\u786e\u3002\u53ef\u5f00\u5c55\u672a\u77e5\u836f\u7269\u4e2d\u6bd2\u5b9a\u6027\u7b5b\u67e5\u53ca\u767e\u8349\u67af\u3001\u53ef\u4e50\u5b9a\u3001\u82ef\u4e8c\u6c2e\u5353\u7c7b\u836f\u7269\u7b49\u5b9a\u91cf\u68c0\u6d4b\uff0c\u53ef\u5feb\u901f\u5b9a\u6027\u9274\u522b\u4f53\u5185\u836f\u7269\u4e2d\u6bd2\u7684\u54c1\u79cd\u6216\u5b9a\u91cf\u4f53\u5185\u836f\u7269\u4e2d\u6bd2\u7684\u6d53\u5ea6\uff0c\u4f7f\u4e34\u5e8a\u533b\u751f\u5728\u62a2\u6551\u4e2d\u6709\u4e86\u5ba2\u89c2\u4f9d\u636e\uff0c\u5927\u5927\u63d0\u9ad8\u4e86\u62a2\u6551\u7684\u6210\u529f\u51e0\u7387\u3002<\/span><\/span>\n<\/p>\n

\n\t        4. \u5168\u8c31\u6c28\u57fa\u9178\u68c0\u6d4b<\/span><\/b>\n<\/p>\n

\n\t  \u901a\u8fc7\u4e0e\u56fd\u5916\u5b9e\u9a8c\u5ba4\u7684\u4ea4\u6d41\u4e0e\u6280\u672f\u5171\u4eab\uff0c\u6210\u529f\u5efa\u7acb\u4e86\u5b9a\u91cf\u68c0\u6d4b\u4eba\u4f53\u5185<\/span>42\u79cd\u6c28\u57fa\u9178\u7684\u51c6\u786e\u65b9\u6cd5\u3002 \u5f00\u5c55\u4ee5\u6db2\u8d28\u8054\u7528\u6280\u672f\u8fdb\u884c\u5168\u8c31\u6c28\u57fa\u9178\u68c0\u6d4b\uff0c\u7075\u654f\u5ea6\u3001\u51c6\u786e\u6027\u3001\u91cd\u73b0\u6027\u597d\uff0c\u800c\u4e14\u68c0\u6d4b\u6c28\u57fa\u9178\u79cd\u7c7b\u66f4\u4e3a\u9f50\u5168\u3002\u5229\u7528\u5df2\u5efa\u7acb\u7684LC-MS\/MS\u5168\u8c31\u6c28\u57fa\u9178\u68c0\u6d4b\u65b9\u6cd5\u53ca\u6c28\u57fa\u9178\u5b9a\u91cf\u7ed3\u679c\u7684\u5206\u6790\u8f6f\u4ef6\uff0c\u7cfb\u7edf\u8bc4\u4ef7\u4eba\u4f5313\u4e2a\u5065\u5eb7\u7cfb\u7edf(\u6c28\/\u80fd\u91cf\u4ee3\u8c22\u7cfb\u7edf\u3001\u5fc5\u9700\u6c28\u57fa\u9178\u8425\u517b\u7cfb\u7edf\u3001\u8461\u8404\u7cd6\u5f02\u751f\u4f5c\u7528\u3001\u795e\u7ecf\u5185\u5206\u6ccc\u4ee3\u8c22\u7cfb\u7edf\u3001\u5c3f\u7d20\u5faa\u73af\u4ee3\u8c22\u7cfb\u7edf\u3001\u4e2d\u67a2\u795e\u7ecf\u4ee3\u8c22\u7cfb\u7edf\u3001\u8f6f\u9aa8\u7ed3\u7f14\u7ec4\u7ec7\u7cfb\u7edf\u3001\u89e3\u6bd2\u6807\u8bb0\u7269\u3001\u8102\u80aa\u4ee3\u8c22\u7cfb\u7edf\u3001\u809d\u810f\u4ee3\u8c22\u7cfb\u7edf\u3001\u514d\u75ab\u7cfb\u7edf\u3001\u9541\u4ee3\u8c22\u7cfb\u7edf\u3001\u808c\u8089\u751f\u957f\u4ee3\u8c22\u7cfb\u7edf)\uff0c\u5df2\u6307\u5bfc500\u591a\u4f8b\u60a3\u8005\u76f8\u5e94\u75c5\u75c7\u7684\u8bca\u65ad\u4e0e\u6cbb\u7597\u3002<\/span><\/span>\n<\/p>\n

\n\t  <\/span><\/span>5. \u65b0\u751f\u513f\u9057\u4f20\u4ee3\u8c22\u75c5\u6db2\u8d28\u7b5b\u67e5<\/span><\/b><\/span>\n<\/p>\n

\n\t  \u9057\u4f20\u4ee3\u8c22\u75be\u75c5\u5c31\u662f\u6709\u4ee3\u8c22\u529f\u80fd\u7f3a\u9677\u7684\u4e00\u7c7b\u9057\u4f20\u75c5\uff0c\u6ca1\u6709\u7279\u522b\u7684\u4e34\u5e8a\u8868\u73b0\uff0c\u4e00\u65e6\u51fa\u73b0\u5f02\u5e38\uff0c\u8eab\u4f53\u548c\u667a\u529b\u7684\u635f\u4f24\u4e0d\u53ef\u9006\u8f6c\uff0c\u662f\u5bfc\u81f4\u513f\u7ae5\u592d\u6298\u6216\u6b8b\u75be\u7684\u4e3b\u8981\u75c5\u56e0\u4e4b\u4e00\u3002\u91c7\u7528\u4e0e\u8f83\u5148\u8fdb\u6280\u672f\u68c0\u6d4b\uff0c\u901a\u8fc7\u4e00\u6b21\u5b9e\u9a8c\u53ef\u4ee5\u7b5b\u67e5\u51fa\u5305\u62ec\u6c28\u57fa\u9178\u3001\u6709\u673a\u9178\u4ee3\u8c22\u7d0a\u4e71\u3001\u8102\u80aa\u9178\u6c27\u5316\u7f3a\u9677\u5728\u5185\u7684<\/span>35\u79cd\u9057\u4f20\u4ee3\u8c22\u6027\u75be\u75c5\u3002\u901a\u8fc7\u65e9\u671f\u8bca\u65ad\u3001\u65e9\u6cbb\u7597\uff0c\u80fd\u6709\u6548\u907f\u514d\u60a3\u513f\u91cd\u8981\u810f\u5668\u51fa\u73b0\u4e0d\u53ef\u9006\u6027\u635f\u5bb3\uff0c\u4fdd\u969c\u513f\u7ae5\u7684\u4f53\u683c\u548c\u667a\u80fd\u53d1\u80b2\u6b63\u5e38\u3002\u540c\u65f6\uff0c\u901a\u8fc7\u63a2\u7d22\u514d\u8d39\u8bd5\u70b9\u5c1d\u8bd5\u666e\u53ca\u65b0\u751f\u513f\u9057\u4f20\u4ee3\u8c22\u75c5\u6db2\u8d28\u7b5b\u67e5\u7684\u6a21\u5f0f\u3002<\/span><\/span>\n<\/p>\n

\n\t<\/p>\n","protected":false},"excerpt":{"rendered":"

\u836f\u4e8b\u90e8\uff08\u672c\u90e8\uff09   \u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u671d\u9633\u533b\u9662\u836f\u4e8b\u90e8\u662f\u8d1f\u8d23\u5168\u9662\u836f\u4e8b\u7ba1\u7406\u3001\u65b0\u836f\u9074\u9009\u8bc4\u4f30\u3001\u4e2d […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[110],"tags":[],"class_list":["post-3920","post","type-post","status-publish","format-standard","hentry","category-pharmacy-clinic-information"],"_links":{"self":[{"href":"https:\/\/www.blpa.com.cn\/index.php?rest_route=\/wp\/v2\/posts\/3920","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.blpa.com.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.blpa.com.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.blpa.com.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.blpa.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3920"}],"version-history":[{"count":1,"href":"https:\/\/www.blpa.com.cn\/index.php?rest_route=\/wp\/v2\/posts\/3920\/revisions"}],"predecessor-version":[{"id":3921,"href":"https:\/\/www.blpa.com.cn\/index.php?rest_route=\/wp\/v2\/posts\/3920\/revisions\/3921"}],"wp:attachment":[{"href":"https:\/\/www.blpa.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3920"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.blpa.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3920"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.blpa.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3920"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}