{"id":3992,"date":"2021-12-28T09:00:33","date_gmt":"2021-12-28T01:00:33","guid":{"rendered":"http:\/\/localhost:9966\/?p=3992"},"modified":"2026-06-23T15:47:21","modified_gmt":"2026-06-23T07:47:21","slug":"%e5%9b%bd%e5%ae%b6%e5%8d%ab%e7%94%9f%e5%81%a5%e5%ba%b7%e5%a7%94%e5%8a%9e%e5%85%ac%e5%8e%85%e5%85%b3%e4%ba%8e%e5%8d%b0%e5%8f%91%e6%96%b0%e5%9e%8b%e6%8a%97%e8%82%bf%e7%98%a4%e8%8d%af%e7%89%a9%e4%b8%b4","status":"publish","type":"post","link":"https:\/\/www.blpa.com.cn\/?p=3992","title":{"rendered":"\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u529e\u516c\u5385\u5173\u4e8e\u5370\u53d1\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219\uff082021\u5e74\u7248\uff09\u7684\u901a\u77e5"},"content":{"rendered":"<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t\n<\/p>\n<p>\n\t\n<\/p>\n<p class=\"MsoNormal\" style=\"text-align:left;\">\n\t<span style=\"color:#444444;font-family:\u7b49\u7ebf;font-size:14pt;line-height:19.5pt;\">\u5404\u7701\u81ea\u6cbb\u533a\u76f4\u8f96\u5e02\u53ca\u65b0\u7586\u751f\u4ea7\u5efa\u8bbe\u5175\u56e2\u536b\u751f\u5065\u5eb7\u59d4\uff1a<\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:21pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;color:#444444;\">\u4e3a\u8fdb\u4e00\u6b65\u89c4\u8303\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\uff0c\u6211\u59d4\u7ec4\u7ec7\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u5408\u7406\u7528\u836f\u4e13\u5bb6\u59d4\u5458\u4f1a\u7275\u5934\u5bf9\u300a\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219<span>(2020<\/span>\u5e74\u7248<span>)<\/span>\u300b\u8fdb\u884c\u4fee\u6539\u5b8c\u5584\uff0c\u5236\u5b9a\u4e86\u300a\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219<span>(2021<\/span>\u5e74\u7248<span>)<\/span>\u300b<span>(<\/span>\u53ef\u5728\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u7f51\u7ad9<span>\u201c<\/span>\u533b\u653f\u533b\u7ba1<span>\u201d<\/span>\u680f\u76ee\u4e0b\u8f7d<span>)<\/span>\u3002\u73b0\u5370\u53d1\u4f60\u4eec\uff0c\u8bf7\u8ba4\u771f\u7ec4\u7ec7\u5b66\u4e60\uff0c\u5e76\u8d2f\u5f7b\u6267\u884c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<span><a href=\"http:\/\/clponline.yiaiwang.cn\/d\/file\/p\/2021\/12-28\/b532977d886e821b4bcca257e08a7797.doc\" target=\"_blank\"><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;color:black;\"><span>\u9644\u4ef6\uff1a<\/span><\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;color:black;\"><span> <\/span><\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;color:black;\"><span>\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219(2021<\/span><\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;color:black;\"><span>\u5e74\u7248)<\/span><\/span><\/a><\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\"><\/p>\n<p><\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;color:#444444;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"right\" style=\"text-align:right;text-indent:21.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;color:#444444;\">&emsp;&emsp;\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u529e\u516c\u5385<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"right\" style=\"text-align:right;text-indent:21.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;color:#444444;\">&emsp;&emsp;<span>2021<\/span>\u5e74<span>12<\/span>\u6708<span>20<\/span>\u65e5<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t<b><span style=\"font-size:24.0pt;line-height:150%;font-family:\u5b8b\u4f53;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t<b><span style=\"font-size:24.0pt;line-height:150%;font-family:\u5b8b\u4f53;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t<b><span style=\"font-size:24.0pt;line-height:150%;font-family:\u5b8b\u4f53;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t<b><span style=\"font-size:24.0pt;line-height:150%;font-family:\u5b8b\u4f53;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<span style=\"font-size:18.0pt;line-height:150%;font-family:;\" \"=\"\">\u9644\u4ef6\uff1a<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t<span style=\"font-size:18.0pt;line-height:150%;font-family:;\" \"=\"\">\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219<\/span><span style=\"font-size:18.0pt;line-height:150%;font-family:;\" \"=\"\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t<span style=\"font-size:18.0pt;line-height:150%;font-family:;\" \"=\"\">\uff08<span>2021<\/span>\u5e74\u7248\uff09<\/span><span style=\"font-size:18.0pt;line-height:150%;font-family:;\" \"=\"\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:36.15pt;\">\n\t<b><span style=\"font-size:18.0pt;line-height:150%;font-family:\u5b8b\u4f53;\">\u76ee \u5f55<\/span><\/b><span style=\"font-size:18.0pt;line-height:150%;font-family:\u5b8b\u4f53;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7b2c\u4e00\u90e8\u5206&emsp;\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u57fa\u672c\u539f\u5219<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<table class=\"MsoNormalTable ke-zeroborder\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"1059\" style=\"border-collapse:collapse;\">\n<tbody>\n<tr>\n<td width=\"1059\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e00\u3001\u75c5\u7406\u7ec4\u7ec7\u5b66\u786e\u8bca\u540e\u65b9\u53ef\u4f7f\u7528\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1059\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u9776\u70b9\u68c0\u6d4b\u540e\u65b9\u53ef\u4f7f\u7528\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1059\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e09\u3001\u4e25\u683c\u9075\u5faa\u9002\u5e94\u8bc1\u7528\u836f\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1059\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u56db\u3001\u4f53\u73b0\u60a3\u8005\u6cbb\u7597\u4ef7\u503c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1059\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e94\u3001\u7279\u6b8a\u60c5\u51b5\u4e0b\u7684\u836f\u7269\u5408\u7406\u4f7f\u7528\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516d\u3001\u91cd\u89c6\u836f\u7269\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:5.25pt;\">\n\t\t\t\t\t<span style=\"line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\">\n\t<b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\">\u7b2c\u4e8c\u90e8\u5206&emsp;\u5404\u7cfb\u7edf\u80bf\u7624\u7684\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219<\/span><\/b><b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\">\n\t<b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\">\u547c\u5438\u7cfb\u7edf\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<table class=\"MsoNormalTable ke-zeroborder\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"1058\" style=\"border-collapse:collapse;\">\n<tbody>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e00\u3001\u5409\u975e\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u5384\u6d1b\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e09\u3001\u57c3\u514b\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u56db\u3001\u963f\u6cd5\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e94\u3001\u8fbe\u53ef\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516d\u3001\u5965\u5e0c\u66ff\u5c3c<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e03\u3001\u963f\u7f8e\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516b\u3001\u4f0f\u7f8e\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e5d\u3001\u514b\u5511\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u3001\u963f\u6765\u66ff\u5c3c<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e00\u3001\u585e\u745e\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e8c\u3001\u6069\u6c99\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e09\u3001\u8d1d\u4f10\u73e0\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u56db\u3001\u91cd\u7ec4\u4eba\u8840\u7ba1\u5185\u76ae\u6291\u5236\u7d20\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e94\u3001\u5b89\u7f57\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u516d\u3001<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u4f9d\u7ef4\u83ab\u53f8<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e03\u3001\u666e\u62c9\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u516b\u3001\u8d5b\u6c83\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e5d\u3001\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u3001\u5e15\u535a\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e00\u3001\u5ea6\u4f10\u5229\u5c24\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e8c\u3001\u963f\u66ff\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e09\u3001\u5361\u745e\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u56db\u3001\u66ff\u96f7\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e94\u3001\u4fe1\u8fea\u5229\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u516d\u3001\u4f0a\u5339\u6728\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\">\n\t<b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\">\u6d88\u5316\u7cfb\u7edf\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<table class=\"MsoNormalTable ke-zeroborder\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"1058\" style=\"border-collapse:collapse;\">\n<tbody>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e00\u3001\u7d22\u62c9\u975e\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u745e\u6208\u975e\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e09\u3001\u4ed1\u4f10\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u56db\u3001\u591a\u7eb3\u975e\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e94\u3001\u963f\u66ff\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516d\u3001\u4fe1\u8fea\u5229\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e03\u3001\u5361\u745e\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516b\u3001\u66ff\u96f7\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e5d\u3001\u5e15\u535a\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u3001\u66f2\u59a5\u73e0\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e00\u3001\u963f\u5e15\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e8c\u3001\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e09\u3001\u7ef4\u8fea\u897f\u59a5\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u56db\u3001\u4f0a\u9a6c\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e94\u3001\u8212\u5c3c\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u516d\u3001\u963f\u4f10\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e03\u3001\u745e\u6d3e\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u516b\u3001\u4f9d\u7ef4\u83ab\u53f8\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e5d\u3001\u7d22\u51e1\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u3001<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e00\u3001\u897f\u59a5\u6614<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e8c\u3001\u544b\u55b9\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\">\n\t<b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\">\u8840\u6db2\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<table class=\"MsoNormalTable ke-zeroborder\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"1061\" style=\"border-collapse:collapse;\">\n<tbody>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e00\u3001\u4f0a\u9a6c\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u8fbe\u6c99\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e09\u3001\u5c3c\u6d1b\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u56db\u3001\u5409\u745e\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e94\u3001\u4f0a\u5e03\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516d\u3001\u8d1d\u6797\u59a5\u6b27\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e03\u3001\u7ef4\u5948\u514b\u62c9\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516b\u3001\u5229\u59a5\u6614\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e5d\u3001\u7ef4\u5e03\u59a5\u6614\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u3001\u897f\u8fbe\u672c\u80fa\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e00\u3001\u787c\u66ff\u4f50\u7c73\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e8c\u3001\u4fe1\u8fea\u5229\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e09\u3001<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u5361\u745e\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u56db\u3001\u66ff\u96f7\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e94\u3001\u6cfd\u5e03\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u516d\u3001\u6765\u90a3\u5ea6\u80fa\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e03\u3001\u6cca\u9a6c\u5ea6\u80fa\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u516b\u3001\u6c99\u5229\u5ea6\u80fa\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e5d\u3001\u4f0a\u6c99\u4f50\u7c73<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u3001\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e00\u3001\u82a6\u53ef\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\">\n\t<b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\">\u6ccc\u5c3f\u7cfb\u7edf\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<table class=\"MsoNormalTable ke-zeroborder\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"1063\" style=\"border-collapse:collapse;\">\n<tbody>\n<tr>\n<td width=\"1063\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e00\u3001\u4f9d\u7ef4\u83ab\u53f8\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1063\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u7d22\u62c9\u975e\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1063\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e09\u3001\u8212\u5c3c\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1063\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u56db\u3001\u963f\u6614\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1063\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e94\u3001\u57f9\u5511\u5e15\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516d\u3001\u4ed1\u4f10\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e03\u3001\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516b\u3001<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e5d\u3001\u66ff\u96f7\u5229\u73e0\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u3001\u7279\u745e\u666e\u5229\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e00\u3001\u5965\u62c9\u5e15\u5229\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\">\n\t<b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\">\u4e73\u817a\u764c\u7528\u836f<\/span><\/b><b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<table class=\"MsoNormalTable ke-zeroborder\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"1063\" style=\"border-collapse:collapse;\">\n<tbody>\n<tr>\n<td width=\"1063\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e00\u3001\u66f2\u59a5\u73e0\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u6069\u7f8e\u66f2\u59a5\u73e0\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e09\u3001\u5e15\u59a5\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u56db\u3001\u4f0a\u5c3c\u59a5\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1063\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e94\u3001\u62c9\u5e15\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516d\u3001\u5421\u54af\u66ff\u5c3c<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e03\u3001\u5948\u62c9\u66ff\u5c3c<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516b\u3001\u54cc\u67cf\u897f\u5229<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e5d\u3001\u963f\u8d1d\u897f\u5229\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u3001\u897f\u8fbe\u672c\u80fa\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\">\n\t<b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\">\u76ae\u80a4\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<table class=\"MsoNormalTable ke-zeroborder\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"1061\" style=\"border-collapse:collapse;\">\n<tbody>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e00\u3001\u4f0a\u9a6c\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u7ef4\u83ab\u975e\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e09\u3001\u8fbe\u62c9\u975e\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u56db\u3001\u66f2\u7f8e\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e94\u3001\u5e15\u535a\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516d\u3001\u7279\u745e\u666e\u5229\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\"> <\/span><\/b><b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\">\u9aa8\u4e0e\u8f6f\u7ec4\u7ec7\u80bf\u7624\u7528\u836f<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e00\u3001\u4f9d\u7ef4\u83ab\u53f8\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u5730\u8212\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e09\u3001\u5b89\u7f57\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\">\n\t<b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\">\u5934\u9888\u90e8\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<table class=\"MsoNormalTable ke-zeroborder\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"1063\" style=\"border-collapse:collapse;\">\n<tbody>\n<tr>\n<td width=\"1063\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e00\u3001\u5c3c\u59a5\u73e0\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u7279\u745e\u666e\u5229\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e09\u3001\u5361\u745e\u5229\u73e0\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u56db\u3001\u7d22\u62c9\u975e\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e94\u3001\u4ed1\u4f10\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516d\u3001\u5b89\u7f57\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e03\u3001\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516b\u3001<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u897f\u59a5\u6614\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e5d\u3001\u5e15\u535a\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:5.25pt;\">\n\t\t\t\t\t<b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\">\u751f\u6b96\u7cfb\u7edf\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e00\u3001\u5965\u62c9\u5e15\u5229\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u3001<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u5c3c\u62c9\u5e15\u5229\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e09\u3001\u6c1f\u5511\u5e15\u5229\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u56db\u3001\u5e15\u7c73\u5e15\u5229\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-family:\u7b49\u7ebf;\"> <\/span><\/b><b><span style=\"font-family:\u7b49\u7ebf;\">\u9644\u8868<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u9644\u8868<span>1<\/span>&emsp;\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u548c\u6cbb\u7597\u8c03\u6574\u65b9\u6848\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u9644\u8868<span>2<\/span>&emsp;\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u5206\u7ea7\u6807\u51c6\u548c\u6cbb\u7597\u5efa\u8bae\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\n\t\n<\/p>\n<p><b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><br \/>\n<\/span><\/b> <\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t<b><span style=\"font-size:18.0pt;line-height:150%;font-family:;\" \"=\"\">\u7b2c\u4e00\u90e8\u5206&emsp;\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t<b><span style=\"font-size:18.0pt;line-height:150%;font-family:;\" \"=\"\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"> <\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u672c\u539f\u5219<span> <\/span><\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e3a\u89c4\u8303\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\uff0c\u63d0\u9ad8\u80bf\u7624\u6cbb\u7597\u7684\u5408\u7406\u7528\u836f\u6c34\u5e73\uff0c\u4fdd\u969c\u533b\u7597\u8d28\u91cf\u548c\u533b\u7597\u5b89\u5168\uff0c\u7ef4\u62a4\u80bf\u7624\u60a3\u8005\u5065\u5eb7\u6743\u76ca\uff0c\u7279\u5236\u5b9a\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219\u3002\u672c\u6307\u5bfc\u539f\u5219\u6d89\u53ca\u7684\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u662f\u6307\u5c0f\u5206\u5b50\u9776\u5411\u836f\u7269\u548c\u5927\u5206\u5b50\u5355\u514b\u9686\u6297\u4f53\u7c7b\u836f\u7269\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6297\u80bf\u7624\u836f\u7269\u7684\u5e94\u7528\u6d89\u53ca\u4e34\u5e8a\u591a\u4e2a\u5b66\u79d1\uff0c\u5408\u7406\u5e94\u7528\u6297\u80bf\u7624\u836f\u7269\u662f\u63d0\u9ad8\u7597\u6548\u3001\u964d\u4f4e\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u7387\u4ee5\u53ca\u5408\u7406\u5229\u7528\u536b\u751f\u8d44\u6e90\u7684\u5173\u952e\u3002\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u9700\u8003\u8651\u836f\u7269\u53ef\u53ca\u6027\u3001\u60a3\u8005\u6cbb\u7597\u610f\u613f\u548c\u75be\u75c5\u9884\u540e\u7b49\u4e09\u5927\u8981\u7d20\u3002\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u662f\u5426\u5408\u7406\uff0c\u57fa\u4e8e\u4ee5\u4e0b\u4e24\u65b9\u9762\uff1a\u6709\u65e0\u6297\u80bf\u7624\u836f\u7269\u5e94\u7528\u6307\u5f81\uff1b\u9009\u7528\u7684\u54c1\u79cd\u53ca\u7ed9\u836f\u65b9\u6848\u662f\u5426\u9002\u5b9c\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e00\u3001\u75c5\u7406\u7ec4\u7ec7\u5b66\u786e\u8bca\u540e\u65b9\u53ef\u4f7f\u7528<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53ea\u6709\u7ecf\u7ec4\u7ec7\u6216\u7ec6\u80de\u5b66\u75c5\u7406\u786e\u8bca\u3001\u6216\u7279\u6b8a\u5206\u5b50\u75c5\u7406\u8bca\u65ad\u6210\u7acb\u7684\u6076\u6027\u80bf\u7624\uff0c\u624d\u6709\u6307\u5f81\u4f7f\u7528\u6297\u80bf\u7624\u836f\u7269\u3002\u5355\u7eaf\u4f9d\u636e\u60a3\u8005\u7684\u4e34\u5e8a\u75c7\u72b6\u3001\u4f53\u5f81\u548c\u5f71\u50cf\u5b66\u7ed3\u679c\u5f97\u51fa\u4e34\u5e8a\u8bca\u65ad\u7684\u80bf\u7624\u60a3\u8005\uff0c\u6ca1\u6709\u6297\u80bf\u7624\u836f\u7269\u6cbb\u7597\u7684\u6307\u5f81\uff0c\u7ecf\u591a\u5b66\u79d1\u4f1a\u8bca\u4e0d\u9002\u5b9c\u624b\u672f\u6216\u6d3b\u68c0\u7684\u75c5\u4f8b\u9664\u5916\u3002\u4f46\u662f\uff0c\u5bf9\u4e8e\u67d0\u4e9b\u96be\u4ee5\u83b7\u53d6\u75c5\u7406\u8bca\u65ad\u7684\u80bf\u7624\uff0c\u5982\u80f0\u817a\u764c\u3001\u598a\u5a20\u6ecb\u517b\u7ec6\u80de\u80bf\u7624\u7b49\uff0c\u5176\u786e\u8bca\u53ef\u53c2\u7167\u56fd\u5bb6\u76f8\u5173\u6307\u5357\u6216\u89c4\u8303\u6267\u884c\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u9776\u70b9\u68c0\u6d4b\u540e\u65b9\u53ef\u4f7f\u7528<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u73b0\u4ee3\u6297\u80bf\u7624\u836f\u7269\u7684\u4e00\u4e2a\u663e\u8457\u7279\u5f81\uff0c\u662f\u51fa\u73b0\u4e00\u6279\u9488\u5bf9\u5206\u5b50\u5f02\u5e38\u7279\u5f81\u7684\u836f\u7269<span>\u2014\u2014<\/span>\u5373\u9776\u5411\u836f\u7269\u3002\u6700\u5177\u4ee3\u8868\u6027\u7684\u836f\u7269\u662f\u9488\u5bf9\u8868\u76ae\u751f\u957f\u56e0\u5b50\u4fe1\u53f7\u901a\u8def\u5f02\u5e38\u7684\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u3002\u76ee\u524d\uff0c\u6839\u636e\u662f\u5426\u9700\u8981\u505a\u9776\u70b9\u68c0\u6d4b\uff0c\u53ef\u4ee5\u5c06\u5e38\u7528\u7684\u5c0f\u5206\u5b50\u9776\u5411\u836f\u7269\u548c\u5927\u5206\u5b50\u5355\u514b\u9686\u6297\u4f53\u7c7b\u836f\u7269\u5206\u4e3a\u4e24\u5927\u7c7b\uff08\u8868<span>1<\/span>\uff09\u3002\u5177\u4f53\u7684\u68c0\u6d4b\u9776\u70b9\u8be6\u89c1\u5404\u7ae0\u8282\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8868<span>1 <\/span>\u5e38\u7528\u7684\u5c0f\u5206\u5b50\u9776\u5411\u836f\u7269\u548c\u5927\u5206\u5b50\u5355\u514b\u9686\u6297\u4f53\u7c7b\u836f\u7269<span><\/span><\/span><\/b>\n<\/p>\n<table class=\"MsoNormalTable\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"1195\" style=\"border-collapse:collapse;border:none;\">\n<tbody>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u75c5\u79cd<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9700\u8981\u68c0\u6d4b\u9776\u70b9\u7684\u836f\u7269<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u9700\u8981\u68c0\u6d4b\u9776\u70b9\u7684\u836f\u7269<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80ba\u764c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5409\u975e\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5384\u6d1b\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57c3\u514b\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u6cd5\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fbe\u53ef\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5965\u5e0c\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u7f8e\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0f\u7f8e\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u514b\u5511\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u6765\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u585e\u745e\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6069\u6c99\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u666e\u62c9\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d5b\u6c83\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u91cd\u7ec4\u4eba\u8840\u7ba1\u5185\u76ae\u6291\u5236\u7d20<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f9d\u7ef4\u83ab\u53f8<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297<sup><span>*<\/span><\/sup><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297<sup><span>*#<\/span><\/sup><span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5ea6\u4f10\u5229\u5c24\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u66ff\u5229\u73e0\u5355\u6297<sup><span>*#<\/span><\/sup><span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5361\u745e\u5229\u73e0\u5355\u6297<sup><span>*<\/span><\/sup><span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66ff\u96f7\u5229\u73e0\u5355\u6297<sup><span>*<\/span><\/sup><span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4fe1\u8fea\u5229\u5355\u6297<sup><span>*<\/span><\/sup><span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f8\u819c\u95f4\u76ae\u7624<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297<sup><span><\/span><\/sup><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u5339\u6728\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u809d\u764c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7d22\u62c9\u975e\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u745e\u6208\u975e\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4ed1\u4f10\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u591a\u7eb3\u975e\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u66ff\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4fe1\u8fea\u5229\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5361\u745e\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66ff\u96f7\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u98df\u7ba1\u764c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5361\u745e\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80c3\u764c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66f2\u59a5\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ef4\u8fea\u897f\u59a5\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u5e15\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80c3\u80a0\u95f4\u8d28\u7624<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u9a6c\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u4f10\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u745e\u6208\u975e\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8212\u5c3c\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u745e\u6d3e\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u795e\u7ecf\u5185\u5206\u6ccc\u7624<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8212\u5c3c\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f9d\u7ef4\u83ab\u53f8<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7d22\u51e1\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ed3\u76f4\u80a0\u764c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u897f\u59a5\u6614\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u745e\u6208\u975e\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u544b\u55b9\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u767d\u8840\u75c5<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u9a6c\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fbe\u6c99\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c3c\u6d1b\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5409\u745e\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u5e03\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u6797\u59a5\u6b27\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ef4\u5948\u514b\u62c9<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6dcb\u5df4\u7624<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5229\u59a5\u6614\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ef4\u5e03\u59a5\u6614\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u897f\u8fbe\u672c\u80fa<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u5e03\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u787c\u66ff\u4f50\u7c73<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4fe1\u8fea\u5229\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5361\u745e\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66ff\u96f7\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cfd\u5e03\u66ff\u5c3c<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u591a\u53d1\u6027\u9aa8\u9ad3\u7624<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u787c\u66ff\u4f50\u7c73<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6765\u90a3\u5ea6\u80fa<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cca\u9a6c\u5ea6\u80fa<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c99\u5229\u5ea6\u80fa<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u6c99\u4f50\u7c73<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fbe\u96f7\u59a5\u5c24\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9aa8\u9ad3\u589e\u6b96\u6027\u75be\u75c5<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u82a6\u53ef\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80be\u764c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f9d\u7ef4\u83ab\u53f8<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7d22\u62c9\u975e\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8212\u5c3c\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u6614\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57f9\u5511\u5e15\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4ed1\u4f10\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c3f\u8def\u4e0a\u76ae\u764c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66ff\u96f7\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7279\u745e\u666e\u5229\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u524d\u5217\u817a\u764c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5965\u62c9\u5e15\u5229<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e73\u817a\u764c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66f2\u59a5\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6069\u7f8e\u66f2\u59a5\u73e0\u5355\u6297<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;color:red;\"><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u59a5\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u5c3c\u59a5\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u62c9\u5e15\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5421\u54af\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5948\u62c9\u66ff\u5c3c<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;color:red;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u54cc\u67cf\u897f\u5229<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u8d1d\u897f\u5229<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u897f\u8fbe\u672c\u80fa<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9ed1\u8272\u7d20\u7624<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u9a6c\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ef4\u83ab\u975e\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fbe\u62c9\u975e\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66f2\u7f8e\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7279\u745e\u666e\u5229\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ed3\u8282\u6027\u786c\u5316\u75c7\u76f8\u5173\u7684\u5ba4\u7ba1\u819c\u4e0b\u5de8\u7ec6\u80de\u661f\u5f62\u7ec6\u80de\u7624<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f9d\u7ef4\u83ab\u53f8<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ed3\u8282\u6027\u786c\u5316\u75c7\u76f8\u5173\u7684\u80be\u8840\u7ba1\u5e73\u6ed1\u808c\u8102\u80aa\u7624<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f9d\u7ef4\u83ab\u53f8<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9aa8\u5de8\u7ec6\u80de\u7624<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5730\u8212\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u817a\u6ce1\u72b6\u8f6f\u7ec4\u7ec7\u8089\u7624<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u900f\u660e\u7ec6\u80de\u8089\u7624<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5176\u4ed6\u665a\u671f\u8f6f\u7ec4\u7ec7\u8089\u7624<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9f3b\u54bd\u764c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c3c\u59a5\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7279\u745e\u666e\u5229\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5361\u745e\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7532\u72b6\u817a\u764c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7d22\u62c9\u975e\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4ed1\u4f10\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u897f\u59a5\u6614\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5375\u5de2\u764c\uff08\u4e00\u7ebf\u7ef4\u6301\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5965\u62c9\u5e15\u5229<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c3c\u62c9\u5e15\u5229<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5375\u5de2\u764c\u3010\u94c2\u654f\u611f\u590d\u53d1\uff08<span>PSR<\/span>\uff09\u7ef4\u6301\u3011<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5965\u62c9\u5e15\u5229<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c3c\u62c9\u5e15\u5229<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c1f\u5511\u5e15\u5229<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5375\u5de2\u764c\uff08\u591a\u7ebf\u590d\u53d1\u6cbb\u7597\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c1f\u5511\u5e15\u5229<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u7c73\u5e15\u5229<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<sup><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">*<\/span><\/sup><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9700\u6392\u9664<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u548c<span>ALK<\/span>\u878d\u5408\u9633\u6027\u7684\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<sup><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">#<\/span><\/sup><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a\u5e15\u535a\u5229\u73e0\u5355\u6297\u5355\u836f\u4f7f\u7528\u3001<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u66ff\u5229\u73e0\u5355\u6297<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5355\u836f\u4f7f\u7528\u524d\u9700\u68c0\u6d4b<span>PD-L1<\/span>\u8868\u8fbe\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u660e\u786e\u4f5c\u7528\u9776\u70b9\u7684\u836f\u7269\uff0c\u987b\u9075\u5faa\u9776\u70b9\u68c0\u6d4b\u540e\u65b9\u53ef\u4f7f\u7528\u7684\u539f\u5219\u3002\u68c0\u6d4b\u6240\u7528\u7684\u4eea\u5668\u8bbe\u5907\u3001\u8bca\u65ad\u8bd5\u5242\u548c\u68c0\u6d4b\u65b9\u6cd5\u5e94\u5f53\u7ecf\u8fc7\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u90e8\u95e8\u6279\u51c6\uff0c\u7279\u522b\u662f\u7ecf\u8fc7\u4f34\u968f\u8bca\u65ad\u9a8c\u8bc1\u7684\u65b9\u6cd5\u3002\u4e0d\u5f97\u5728\u672a\u505a\u76f8\u5173\u68c0\u67e5\u7684\u60c5\u51b5\u4e0b\u76f2\u76ee\u7528\u836f\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e09\u3001\u4e25\u683c\u9075\u5faa\u9002\u5e94\u8bc1\u7528\u836f<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6297\u80bf\u7624\u836f\u7269\u7684\u836f\u54c1\u8bf4\u660e\u4e66\u662f\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u7684\u6cd5\u5b9a\u4f9d\u636e\uff0c\u5176\u89c4\u5b9a\u7684\u9002\u5e94\u8bc1\u7ecf\u8fc7\u4e86\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u90e8\u95e8\u6279\u51c6\u3002\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u987b\u9075\u5faa\u836f\u54c1\u8bf4\u660e\u4e66\uff0c\u4e0d\u80fd\u968f\u610f\u8d85\u9002\u5e94\u8bc1\u4f7f\u7528\u3002\u5728\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u8fc7\u7a0b\u4e2d\uff0c\u53d1\u73b0\u65b0\u7684\u5177\u6709\u9ad8\u7ea7\u522b\u5faa\u8bc1\u533b\u5b66\u8bc1\u636e\u7684\u7528\u6cd5\u4f46\u836f\u54c1\u8bf4\u660e\u4e66\u4e2d\u672a\u4f53\u73b0\u7684\uff0c\u533b\u7597\u673a\u6784\u548c\u533b\u52a1\u4eba\u5458\u53ef\u53ca\u65f6\u5411\u836f\u54c1\u751f\u4ea7\u5382\u5546\u53cd\u9988\uff0c\u5efa\u8bae\u5176\u4e3b\u52a8\u5411\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u90e8\u95e8\u7533\u62a5\uff0c\u53ca\u65f6\u66f4\u65b0\u76f8\u5e94\u836f\u54c1\u8bf4\u660e\u4e66\uff0c\u4ee5\u4fdd\u8bc1\u836f\u54c1\u8bf4\u660e\u4e66\u7684\u79d1\u5b66\u6027\u3001\u6743\u5a01\u6027\uff0c\u6709\u6548\u6307\u5bfc\u4e34\u5e8a\u7528\u836f\u3002\u7279\u522b\u662f\u6709\u6761\u4ef6\u5feb\u901f\u6279\u51c6\u4e0a\u5e02\u7684\u836f\u54c1\uff0c\u66f4\u5e94\u5f53\u4fdd\u8bc1\u836f\u54c1\u8bf4\u660e\u4e66\u7684\u65f6\u6548\u6027\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56db\u3001\u4f53\u73b0\u60a3\u8005\u6cbb\u7597\u4ef7\u503c<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u73b0\u4ee3\u4e34\u5e8a\u80bf\u7624\u5b66\u9ad8\u5ea6\u91cd\u89c6\u6076\u6027\u80bf\u7624\u60a3\u8005\u7684\u6cbb\u7597\u4ef7\u503c\u3002\u5176\u6838\u5fc3\u601d\u60f3\u662f\uff0c\u5728\u76f8\u540c\u6cbb\u7597\u6210\u672c\u524d\u63d0\u4e0b\uff0c\u4f7f\u60a3\u8005\u83b7\u5f97\u66f4\u957f\u7684\u751f\u5b58\u65f6\u95f4\u548c\u66f4\u597d\u7684\u751f\u6d3b\u8d28\u91cf\u3002\u5728\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u4e2d\uff0c\u5e94\u5f53\u5145\u5206\u8003\u8651\u6297\u80bf\u7624\u836f\u7269\u7684\u6210\u672c<span>&#8211;<\/span>\u6548\u679c\u6bd4\uff0c\u4f18\u5148\u9009\u62e9\u5177\u6709\u836f\u7269\u7ecf\u6d4e\u5b66\u8bc4\u4ef7\u4f18\u52bf\u8bc1\u636e\u7684\u54c1\u79cd\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e94\u3001\u7279\u6b8a\u60c5\u51b5\u4e0b\u7684\u836f\u7269\u5408\u7406\u4f7f\u7528<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u968f\u7740\u764c\u75c7\u6cbb\u7597\u4e34\u5e8a\u5b9e\u8df5\u7684\u5feb\u901f\u53d1\u5c55\uff0c\u76ee\u524d\u4e0a\u5e02\u7684\u6297\u80bf\u7624\u836f\u7269\u5c1a\u4e0d\u80fd\u5b8c\u5168\u6ee1\u8db3\u80bf\u7624\u60a3\u8005\u7684\u7528\u836f\u9700\u6c42\uff0c\u836f\u54c1\u8bf4\u660e\u4e66\u4e5f\u5f80\u5f80\u6ede\u540e\u4e8e\u4e34\u5e8a\u5b9e\u8df5\uff0c\u4e00\u4e9b\u5177\u6709\u9ad8\u7ea7\u522b\u5faa\u8bc1\u533b\u5b66\u8bc1\u636e\u7684\u7528\u6cd5\u672a\u80fd\u53ca\u65f6\u5728\u836f\u54c1\u8bf4\u660e\u4e66\u4e2d\u660e\u786e\u89c4\u5b9a\u3002\u5728\u5c1a\u65e0\u66f4\u597d\u6cbb\u7597\u624b\u6bb5\u7b49\u7279\u6b8a\u60c5\u51b5\u4e0b\uff0c\u533b\u7597\u673a\u6784\u5e94\u5f53\u5236\u5b9a\u76f8\u5e94\u7ba1\u7406\u5236\u5ea6\u3001\u6280\u672f\u89c4\u8303\uff0c\u5bf9\u836f\u54c1\u8bf4\u660e\u4e66\u4e2d\u672a\u660e\u786e\u3001\u4f46\u5177\u6709\u5faa\u8bc1\u533b\u5b66\u8bc1\u636e\u7684\u836f\u54c1\u7528\u6cd5\u8fdb\u884c\u4e25\u683c\u7ba1\u7406\u3002\u7279\u6b8a\u60c5\u51b5\u4e0b\u6297\u80bf\u7624\u836f\u7269\u7684\u4f7f\u7528\u6743\u5e94\u5f53\u4ec5\u9650\u4e8e\u4e09\u7ea7\u533b\u9662\u6388\u6743\u7684\u5177\u6709\u9ad8\u7ea7\u4e13\u4e1a\u6280\u672f\u804c\u79f0\u7684\u533b\u5e08\uff0c\u5145\u5206\u9075\u5faa\u60a3\u8005\u77e5\u60c5\u540c\u610f\u539f\u5219\uff0c\u5e76\u4e14\u5e94\u5f53\u505a\u597d\u7528\u836f\u76d1\u6d4b\u548c\u8ddf\u8e2a\u89c2\u5bdf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7279\u6b8a\u60c5\u51b5\u4e0b\u6297\u80bf\u7624\u836f\u7269\u5faa\u8bc1\u533b\u5b66\u8bc1\u636e\u91c7\u7eb3\u6839\u636e\u4f9d\u6b21\u662f\uff1a\u5176\u4ed6\u56fd\u5bb6\u6216\u5730\u533a\u836f\u54c1\u8bf4\u660e\u4e66\u4e2d\u5df2\u6ce8\u660e\u7684\u7528\u6cd5\uff0c\u56fd\u9645\u6743\u5a01\u5b66\u534f\u4f1a\u6216\u7ec4\u7ec7\u53d1\u5e03\u7684\u8bca\u7597\u89c4\u8303\u3001\u4e34\u5e8a\u8bca\u7597\u6307\u5357\uff0c\u56fd\u5bb6\u7ea7\u5b66\u534f\u4f1a\u53d1\u5e03\u7684\u7ecf\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u5458\u4f1a\u8ba4\u53ef\u7684\u8bca\u7597\u89c4\u8303\u3001\u4e34\u5e8a\u8bca\u7597\u6307\u5357\u548c\u4e34\u5e8a\u8def\u5f84\u7b49\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u516d\u3001\u91cd\u89c6\u836f\u7269\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6297\u80bf\u7624\u836f\u7269\u7684\u76f8\u5173\u6027\u6bd2\u526f\u4f5c\u7528\u53d1\u751f\u7387\u8f83\u9ad8\uff0c\u4e5f\u5bb9\u6613\u4ea7\u751f\u7f55\u89c1\u7684\u6bd2\u526f\u4f5c\u7528\uff0c\u56e0\u6b64\u6297\u80bf\u7624\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u62a5\u544a\u5c24\u4e3a\u91cd\u8981\u3002\u533b\u7597\u673a\u6784\u5e94\u5f53\u5efa\u7acb\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u3001\u836f\u54c1\u635f\u5bb3\u4e8b\u4ef6\u76d1\u6d4b\u62a5\u544a\u5236\u5ea6\uff0c\u5e76\u6309\u7167\u56fd\u5bb6\u6709\u5173\u89c4\u5b9a\u5411\u76f8\u5173\u90e8\u95e8\u62a5\u544a\u3002\u533b\u7597\u673a\u6784\u5e94\u5f53\u5c06\u6297\u80bf\u7624\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u62a5\u544a\u7eb3\u5165\u533b\u7597\u8d28\u91cf\u8003\u6838\u4f53\u7cfb\uff0c\u5b9a\u671f\u5206\u6790\u548c\u62a5\u544a\u6297\u80bf\u7624\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u7684\u52a8\u6001\u548c\u8d8b\u52bf\u3002\u4e34\u5e8a\u533b\u5e08\u548c\u4e34\u5e8a\u836f\u5e08\u5e94\u5f53\u5bc6\u5207\u968f\u8bbf\u60a3\u8005\u7684\u7528\u836f\u76f8\u5173\u6bd2\u6027\uff0c\u5e76\u53ca\u65f6\u4e0a\u62a5\u4e0d\u826f\u53cd\u5e94\uff0c\u5c24\u5176\u662f\u4e25\u91cd\u7684\u548c\u65b0\u53d1\u73b0\u7684\u4e0d\u826f\u53cd\u5e94\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p><b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><br \/>\n<\/span><\/b> <\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:36.0pt;\">\n\t<b><span style=\"font-size:18.0pt;line-height:150%;font-family:;\" \"=\"\">\u7b2c\u4e8c\u90e8\u5206&emsp;\u5404\u7cfb\u7edf\u80bf\u7624\u7684\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u547c\u5438\u7cfb\u7edf\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e00\u3001\u5409\u975e\u66ff\u5c3c<span> Gefitinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>250mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">EGFR<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff09\u57fa\u56e0\u5177\u6709\u654f\u611f\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08<span>NSCLC<\/span>\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08<span>NMPA<\/span>\uff09\u6279\u51c6\u7684<span>EGFR<\/span>\u57fa\u56e0\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230\u7684<span>EGFR<\/span>\u654f\u611f\u7a81\u53d8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80bf\u7624\u7ec4\u7ec7\u548c\u8840\u6db2\u5747\u53ef\u7528\u4e8e<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u68c0\u6d4b\uff0c\u4f46\u7ec4\u7ec7\u68c0\u6d4b\u4f18\u5148\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u6761\u6807\u51c6\u4e5f\u9002\u7528\u4e8e\u5176\u4ed6\u5c0f\u5206\u5b50\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u671f\u95f4\u56e0\u836f\u7269\u6bd2\u6027\u4e0d\u53ef\u8010\u53d7\u65f6\uff0c\u53ef\u5728\u540c\u4e00\u4ee3\u836f\u7269\u4e4b\u95f4\u66ff\u6362\uff0c\u5982\u75be\u75c5\u8fdb\u5c55\u5219\u4e0d\u80fd\u5728\u540c\u4e00\u4ee3\u836f\u7269\u4e4b\u95f4\u66ff\u6362\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u5f71\u50cf\u5b66\u663e\u793a\u7f13\u6162\u8fdb\u5c55\u4f46\u4e34\u5e8a\u75c7\u72b6\u672a\u53d1\u751f\u6076\u5316\u7684\u60a3\u8005\uff0c\u53ef\u4ee5\u7ee7\u7eed\u4f7f\u7528\u539f\u836f\u7269\uff1b\u663e\u793a\u5be1\u8fdb\u5c55\u6216\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u8fdb\u5c55\u60a3\u8005\uff0c\u53ef\u4ee5\u7ee7\u7eed\u4f7f\u7528\u539f\u836f\u7269\u52a0\u5c40\u90e8\u6cbb\u7597\uff1b\u5bf9\u4e8e\u5e7f\u6cdb\u8fdb\u5c55\u7684\u60a3\u8005\uff0c\u5efa\u8bae\u6539\u6362\u4e3a\u5176\u4ed6\u6cbb\u7597\u65b9\u6848\u3002\u672c\u6761\u6807\u51c6\u4e5f\u9002\u7528\u4e8e\u5176\u4ed6\u5c0f\u5206\u5b50\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u76ae\u80a4\u9ecf\u819c\u53cd\u5e94\u548c\u8179\u6cfb\uff1b\u5e94\u7279\u522b\u6ce8\u610f\u95f4\u8d28\u6027\u80ba\u708e\u3001\u809d\u810f\u6bd2\u6027\u548c\u773c\u90e8\u75c7\u72b6\u7684\u53d1\u751f\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u5242\u91cf\u8c03\u6574\uff1a\uff08<span>1<\/span>\uff09<span>CYP3A4<\/span>\u5f3a\u8bf1\u5bfc\u5242\uff1a\u5982\u679c\u672a\u51fa\u73b0\u91cd\u5ea6\u836f\u7269\u4e0d\u826f\u53cd\u5e94\uff0c\u5409\u975e\u66ff\u5c3c\u65e5\u5242\u91cf\u53ef\u589e\u52a0\u81f3<span>500mg<\/span>\uff0c\u4e2d\u6b62\u5f3a\u6548<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u7ed9\u836f\u540e<span>7<\/span>\u5929\uff0c\u91cd\u65b0\u5f00\u59cb\u5409\u975e\u66ff\u5c3c<span>250mg<\/span>\u7ed9\u836f\u3002\uff08<span>2<\/span>\uff09<span>CYP3A4<\/span>\u6291\u5236\u5242\uff1a\u5f3a\u6548<span>CYP3A4<\/span>\u6291\u5236\u5242\uff08\u5982\u916e\u5eb7\u5511\u548c\u4f0a\u66f2\u5eb7\u5511\uff09\u80fd\u964d\u4f4e\u5409\u975e\u66ff\u5c3c\u4ee3\u8c22\uff0c\u589e\u52a0\u5176\u8840\u6d46\u6d53\u5ea6\u3002\u5409\u975e\u66ff\u5c3c\u4e0e\u5f3a\u6548<span>CYP3A4<\/span>\u6291\u5236\u5242\u5408\u5e76\u7528\u836f\u65f6\uff0c\u5e94\u76d1\u6d4b\u4e0d\u826f\u53cd\u5e94\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u67d0\u4e9b\u80bf\u7624\u6025\u75c7\u7684\u60c5\u51b5\u4e0b\u5982\u8111\u8f6c\u79fb\u660f\u8ff7\u6216\u547c\u5438\u8870\u7aed\uff0c\u5728\u5145\u5206\u77e5\u60c5\u7684\u60c5\u51b5\u4e0b\uff0c\u5bf9\u4e0d\u5438\u70df\u7684\u80ba\u817a\u764c\u60a3\u8005\uff0c\u53ef\u8003\u8651\u5728\u9a71\u52a8\u57fa\u56e0\u4e0d\u660e\u7684\u60c5\u51b5\u4e0b\u5c3d\u5feb\u7528\u836f\u3002\u4e00\u65e6\u75c5\u60c5\u7f13\u89e3\uff0c\u5fc5\u987b\u8865\u5145\u8fdb\u884c<span>EGFR<\/span>\u7a81\u53d8\u7684\u7ec4\u7ec7\u6216\u8840\u6db2\u68c0\u6d4b\u3002\uff08\u672c\u6761\u6807\u51c6\u4e5f\u9002\u7528\u4e8e\u5176\u4ed6<span>EGFR<\/span>\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff09<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u5384\u6d1b\u66ff\u5c3c<span> Erlotinib<\/span><\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>100mg<\/span>\u3001<span>150mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">EGFR<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u56e0\u5177\u6709\u654f\u611f\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:21.0pt;\">\n<table cellpadding=\"0\" cellspacing=\"0\" width=\"100%\">\n<tbody>\n<tr>\n<td>\n<div>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t\t<span style=\"font-size:8.0pt;\"><\/span>\n\t\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t\t<span style=\"font-size:7.5pt;font-family:\u5b8b\u4f53;\">\u672c\u6307\u5bfc\u539f\u5219\u201c\u5408\u7406\u7528\u836f\u8981\u70b9\u201d\u5e26<b><sup>\u203b<\/sup><\/b>\u90e8\u5206\u4e3a\u7279\u6b8a\u60c5\u51b5\u4e0b\u589e\u52a0\u9002\u5e94\u8bc1\u7528\u836f\u4e13\u5bb6\u5171\u8bc6\u3002<\/span><span style=\"font-size:8.0pt;\"><\/span>\n\t\t\t\t\t\t<\/p>\n<\/p><\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"506\" height=\"55\" src=\"file:\/\/C:\/Users\/%E7%8E%8B%E8%B1%AB\/AppData\/Local\/Temp\/msohtmlclip1\/01\/clip_image002.png\" align=\"left\" alt=\"\u6587\u672c\u6846: \u672c\u6307\u5bfc\u539f\u5219\u201c\u5408\u7406\u7528\u836f\u8981\u70b9\u201d\u5e26\u203b\u90e8\u5206\u4e3a\u7279\u6b8a\u60c5\u51b5\u4e0b\u589e\u52a0\u9002\u5e94\u8bc1\u7528\u836f\u4e13\u5bb6\u5171\u8bc6\u3002 \" \/><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684<span>EGFR<\/span>\u57fa\u56e0\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230\u7684<span>EGFR<\/span>\u654f\u611f\u7a81\u53d8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u8111\u8f6c\u79fb\u7684<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u7684<span>NSCLC<\/span>\u60a3\u8005\u548c<span>21<\/span>\u5916\u663e\u5b50<span>L858R<\/span>\u7f6e\u6362\u7a81\u53d8\u9633\u6027\u665a\u671f<span>NSCLC<\/span>\u60a3\u8005\uff0c\u53ef\u9009\u62e9\u5384\u6d1b\u66ff\u5c3c\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5384\u6d1b\u66ff\u5c3c\u5355\u836f\u7528\u4e8e<span>NSCLC<\/span>\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>150mg\/d<\/span>\uff0c\u81f3\u5c11\u5728\u996d\u524d<span>1<\/span>\u5c0f\u65f6\u6216\u996d\u540e<span>2<\/span>\u5c0f\u65f6\u670d\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u76ae\u80a4\u9ecf\u819c\u53cd\u5e94\u548c\u8179\u6cfb\u3002\u5e94\u7279\u522b\u6ce8\u610f\u95f4\u8d28\u6027\u80ba\u708e\u3001\u809d\u529f\u80fd\u5f02\u5e38\u548c\u773c\u90e8\u75c7\u72b6\u7684\u53d1\u751f\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u4e0e<span>CYP3A4<\/span>\u5f3a\u6291\u5236\u5242\u6216\u5f3a\u8bf1\u5bfc\u5242\u8054\u5408\u4f7f\u7528\u3002\u907f\u514d\u5384\u6d1b\u66ff\u5c3c\u4e0e\u80fd\u663e\u8457\u4e14\u6301\u7eed\u5347\u9ad8\u80c3\u6db2<span>pH<\/span>\u503c\u7684\u836f\u7269\u5408\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5438\u70df\u4f1a\u5bfc\u81f4\u5384\u6d1b\u66ff\u5c3c\u7684\u66b4\u9732\u91cf\u964d\u4f4e\uff0c\u5efa\u8bae\u60a3\u8005\u6212\u70df\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7f8e\u56fd<span>FDA<\/span>\u6279\u51c6\u5384\u6d1b\u66ff\u5c3c\u4e0e\u5409\u897f\u4ed6\u6ee8\u8054\u5408\u7528\u4e8e\u5c40\u90e8\u665a\u671f\u3001\u65e0\u6cd5\u5207\u9664\u6216\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff0c\u76ee\u524d\u56fd\u5185\u5c1a\u672a\u83b7\u6279\u6b64\u9002\u5e94\u8bc1\uff0c\u53ef\u5728\u4e0e\u60a3\u8005\u5145\u5206\u6c9f\u901a\u7684\u60c5\u51b5\u4e0b\u4f7f\u7528\u3002\u7528\u6cd5\u4e3a<span>l00mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e09\u3001\u57c3\u514b\u66ff\u5c3c<span> Icotinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>125mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.EGFR<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u56e0\u5177\u6709\u654f\u611f\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2161\uff5e\u2162<span>A<\/span>\u671f\u4f34\u6709<span>EGFR<\/span>\u57fa\u56e0\u654f\u611f\u7a81\u53d8<span>NSCLC<\/span>\u7684\u672f\u540e\u8f85\u52a9\u6cbb\u7597\u3002 <span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684<span>EGFR<\/span>\u57fa\u56e0\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230\u7684<span>EGFR<\/span>\u654f\u611f\u7a81\u53d8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.EGFR<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u56e0\u654f\u611f\u7a81\u53d8\u7684\u2161\uff5e\u2162<span>A<\/span>\u671f<span>NSCLC<\/span>\u60a3\u8005\u5b8c\u5168\u80bf\u7624\u5207\u9664\u672f\u540e\u63a8\u8350\u57c3\u514b\u66ff\u5c3c\u8f85\u52a9\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e38\u89c4\u5242\u91cf\u662f<span>125mg<\/span><\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\/<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b21<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u6bcf\u5929\u4e09\u6b21\uff0c\u5bf9\u4e8e<span>21<\/span>\u5916\u663e\u5b50<span>L858R<\/span>\u7f6e\u6362\u7a81\u53d8\u9633\u6027\u665a\u671f<span>NSCLC<\/span>\u60a3\u8005\uff0c\u53ef\u4ee5\u4f7f\u7528<span>250mg<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\/<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b21<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u6bcf\u5929\u4e09\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u8111\u8f6c\u79fb\u7684<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u7684<span>NSCLC<\/span>\u60a3\u8005\uff0c\u53ef\u4f18\u5148\u9009\u62e9\u57c3\u514b\u66ff\u5c3c\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u826f\u53cd\u5e94\u4e3b\u8981\u4e3a\u5e38\u89c1\u7684<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>2<\/span>\u7ea7<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ae\u75b9\u548c\u8179\u6cfb\uff0c\u5e94\u7279\u522b\u5173\u6ce8\u95f4\u8d28\u6027\u80ba\u708e\u7684\u53d1\u751f\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57c3\u514b\u66ff\u5c3c\u4e3b\u8981\u901a\u8fc7<span>CYP450<\/span>\u7cfb\u7edf\u7684<span>CYP2C19<\/span>\u548c<span>CYP3A4<\/span>\u4ee3\u8c22\uff0c\u5bf9<span>CYP2C9<\/span>\u548c<span>CYP3A4<\/span>\u6709\u660e\u663e\u7684\u6291\u5236\u4f5c\u7528\uff0c\u4e0e\u4e0a\u8ff0\u4e24\u79cd\u4ee3\u8c22\u9176\u8bf1\u5bfc\u5242\u548c\u5e95\u7269\u836f\u7269\u5408\u7528\u65f6\u5e94\u6ce8\u610f\u6f5c\u5728\u7684\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56db\u3001\u963f\u6cd5\u66ff\u5c3c<span> Afatinib<\/span><\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>30mg<\/span>\u3001<span>40mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5177\u6709<span>EGFR<\/span>\u57fa\u56e0\u654f\u611f\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\uff0c\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7<span>EGFR<\/span>\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08<span>EGFR-TKI<\/span>\uff09\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u542b\u94c2\u5316\u7597\u671f\u95f4\u6216\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u9cde\u72b6\u7ec4\u7ec7\u5b66\u7c7b\u578b\u7684<span>NSCLC<\/span>\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e00\u7ebf\u6cbb\u7597<span>EGFR<\/span>\u57fa\u56e0\u654f\u611f\u7a81\u53d8\u7684\u665a\u671f<span>NSCLC<\/span>\u60a3\u8005\uff0c\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684<span>EGFR<\/span>\u57fa\u56e0\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230\u7684<span>EGFR<\/span>\u57fa\u56e0\u654f\u611f\u7a81\u53d8\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u867d\u7136\u836f\u54c1\u8bf4\u660e\u4e66\u663e\u793a\u963f\u6cd5\u66ff\u5c3c\u4e0d\u9700\u8fdb\u884c\u57fa\u56e0\u68c0\u6d4b\u53ef\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u542b\u94c2\u5316\u7597\u671f\u95f4\u6216\u5316\u7597\u540e\u8fdb\u5c55\u7684\u665a\u671f\u80ba\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\uff0c\u4f46\u4ecd\u7136\u4e0d\u63a8\u8350\u7528\u4e8e<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u7684\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u975e\u5e38\u89c1<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u60a3\u8005\uff0c\u4f18\u5148\u4f7f\u7528\u963f\u6cd5\u66ff\u5c3c\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a<span>40mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u53ef\u6839\u636e\u60a3\u8005\u8010\u53d7\u6027\u8fdb\u884c\u5242\u91cf\u8c03\u6574\uff0c\u5242\u91cf\u8c03\u6574\u65b9\u6848\u89c1\u8868<span>2<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8868<span>2 <\/span>\u963f\u6cd5\u66ff\u5c3c\u63a8\u8350\u5242\u91cf\u8c03\u6574\u65b9\u6848<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<div align=\"center\">\n<table class=\"MsoNormalTable\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"1123\" style=\"border-collapse:collapse;border:none;\">\n<tbody>\n<tr>\n<td width=\"461\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">CTCAE<\/span><\/b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">a<\/span><\/sup><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08<span>4.0<\/span>\u7248\uff09\u836f\u7269\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"661\" colspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u6cd5\u66ff\u5c3c\u7684\u5efa\u8bae\u7ed9\u836f\u91cf<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"461\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>2<\/span>\u7ea7<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"321\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u4e2d\u65ad<sup><span>b<\/span><\/sup><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"340\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u8c03\u6574\u5242\u91cf<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"461\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\uff08\u5ef6\u957f<sup><span>c<\/span><\/sup>\u6216\u4e0d\u8010\u53d7\uff09\u6216\u2265<span>3<\/span>\u7ea7<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"321\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e2d\u65ad\u76f4\u5230\u6062\u590d\u81f3<span>0\/1<\/span>\u7ea7<sup><span>b<\/span><\/sup><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"340\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4ee5\u51cf\u91cf<span>10mg<\/span>\u9012\u51cf\u7ee7\u7eed<sup><span>d<\/span><\/sup><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p class=\"MsoNormal\" style=\"margin-left:0cm;text-indent:28.0pt;\">\n\t<sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">a<\/span><\/sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7f8e\u56fd\u56fd\u7acb\u764c\u75c7\u7814\u7a76\u6240\uff08<span>NCI<\/span>\uff09\u4e0d\u826f\u4e8b\u4ef6\u901a\u7528\u672f\u8bed\u6807\u51c6<span>4.0<\/span>\u7248\u3002<\/span><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/sup>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">b<\/span><\/sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53d1\u751f\u8179\u6cfb\u65f6\uff0c\u5e94\u7acb\u5373\u4f7f\u7528\u6297\u8179\u6cfb\u836f\u7269\uff08\u5982\u6d1b\u54cc\u4e01\u80fa\uff09\uff0c\u5e76\u4e14\u5bf9\u4e8e\u6301\u7eed\u8179\u6cfb\u7684\u60c5\u51b5\u5e94\u7ee7\u7eed\u7528\u836f\u76f4\u5230\u8179\u6cfb\u505c\u6b62\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"margin-left:0cm;text-indent:28.0pt;\">\n\t<sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">c<\/span><\/sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8179\u6cfb\uff1e<span>48<\/span>\u5c0f\u65f6\u548c<span>\/<\/span>\u6216\u76ae\u75b9\uff1e<span>7<\/span>\u5929\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"margin-left:0cm;text-indent:28.0pt;\">\n\t<sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">d<\/span><\/sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u60a3\u8005\u4e0d\u80fd\u8010\u53d7\u6bcf\u5929<span>20mg<\/span>\uff0c\u5e94\u8003\u8651\u6c38\u4e45\u505c\u7528\u672c\u54c1\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u4e34\u5e8a\u533b\u751f\u8bc4\u4ef7\u4e3a\u8010\u53d7\u6027\u5dee\u7684\u60a3\u8005\uff0c\u53ef\u4f7f\u7528<span>30mg<\/span>\u4f5c\u4e3a\u63a8\u8350\u5242\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u6cd5\u66ff\u5c3c\u4e0d\u5e94\u4e0e\u98df\u7269\u540c\u670d\uff0c\u5e94\u5f53\u5728\u8fdb\u98df\u540e\u81f3\u5c11<span>3<\/span>\u5c0f\u65f6\u6216\u8fdb\u98df\u524d\u81f3\u5c11<span>1<\/span>\u5c0f\u65f6\u670d\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u8179\u6cfb\u3001\u76ae\u80a4\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\u3001\u95f4\u8d28\u6027\u80ba\u708e\u7b49\u4e0d\u826f\u4e8b\u4ef6\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u9700\u8981\u4f7f\u7528<span>P-<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\uff0c\u5e94\u91c7\u7528\u4ea4\u9519\u5242\u91cf\u7ed9\u836f\uff0c\u5c3d\u53ef\u80fd\u5ef6\u957f\u4e0e\u963f\u6cd5\u66ff\u5c3c\u7ed9\u836f\u7684\u95f4\u9694\u65f6\u95f4\u3002<span>P-<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\u5e94\u5728\u963f\u6cd5\u66ff\u5c3c\u7ed9\u836f\u540e\u95f4\u9694<span>6<\/span>\u5c0f\u65f6\uff08<span>P-<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\u6bcf\u5929\u4e24\u6b21\u7ed9\u836f\uff09\u6216<span>12<\/span>\u5c0f\u65f6\uff08<span>P-<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\u6bcf\u5929\u4e00\u6b21\u7ed9\u836f\uff09\u7ed9\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u6cd5\u66ff\u5c3c\u4e0d\u901a\u8fc7<span>CYP<\/span>\u9176\u7cfb\u4ee3\u8c22\uff0c\u4f53\u5916\u5b9e\u9a8c\u7814\u7a76\u663e\u793a\u4e0e<span>CYP<\/span>\u6291\u5236\u5242\u6216\u8bf1\u5bfc\u5242\u8054\u7528\u65f6\uff0c\u5bf9\u963f\u6cd5\u66ff\u5c3c\u7684\u66b4\u9732\u91cf\u65e0\u660e\u663e\u5f71\u54cd\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u542b\u6709\u4e73\u7cd6\uff0c\u60a3\u6709\u7f55\u89c1\u9057\u4f20\u6027\u534a\u4e73\u7cd6\u4e0d\u8010\u75c7\u3001\u4e73\u7cd6\u9176\u7f3a\u4e4f\u75c7\u6216\u8461\u8404\u7cd6<span>&#8211;<\/span>\u534a\u4e73\u7cd6\u5438\u6536\u4e0d\u826f\u7684\u60a3\u8005\u4e0d\u5e94\u670d\u7528\u6b64\u836f\u54c1\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e94\u3001\u8fbe\u53ef\u66ff\u5c3c<span> Dacomitinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>15mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5355\u836f\u7528\u4e8e<span>EGFR19<\/span>\u5916\u663e\u5b50\u7f3a\u5931\u7a81\u53d8\u6216<span>21<\/span>\u5916\u663e\u5b50<span>L858R<\/span>\u7f6e\u6362\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684<span>EGFR<\/span>\u57fa\u56e0\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230\u7684<span>EGFR19<\/span>\u5916\u663e\u5b50\u7f3a\u5931\u7a81\u53d8\u6216<span>21<\/span>\u5916\u663e\u5b50<span>L858R<\/span>\u7f6e\u6362\u7a81\u53d8\u9633\u6027\u7684\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e<span>21<\/span>\u5916\u663e\u5b50<span>L858R<\/span>\u7f6e\u6362\u7a81\u53d8\u9633\u6027\u60a3\u8005\uff0c\u4f18\u5148\u63a8\u8350\u8fbe\u53ef\u66ff\u5c3c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u60a3\u8005\u63a5\u53d7\u672c\u836f\u7269\u6cbb\u7597\u76f4\u5230\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u65e0\u6cd5\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a<span>45mg<\/span>\u53e3\u670d\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u53ef\u4e0e\u98df\u7269\u540c\u670d\uff0c\u4e5f\u53ef\u4e0d\u4e0e\u98df\u7269\u540c\u670d\u3002\u5bf9\u4e8e\u4e34\u5e8a\u533b\u751f\u8bc4\u4ef7\u4e3a\u8010\u53d7\u6027\u5dee\u7684\u5e74\u8001\u4f53\u5f31\u60a3\u8005\uff0c\u8d77\u59cb\u5242\u91cf\u53ef\u4ece<span>30mg<\/span>\u53e3\u670d\u3001\u6bcf\u5929\u4e00\u6b21\u5f00\u59cb\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6bcf\u5929\u5728\u5927\u81f4\u76f8\u540c\u7684\u65f6\u95f4\u670d\u7528\u672c\u54c1\u3002\u5982\u679c\u60a3\u8005\u5455\u5410\u6216\u6f0f\u670d\u4e00\u5242\uff0c\u4e0d\u5e94\u8ffd\u52a0\u5242\u91cf\u6216\u8865\u5145\u670d\u7528\u6f0f\u670d\u5242\u91cf\uff0c\u800c\u5e94\u5728\u4e0b\u4e00\u6b21\u7684\u670d\u836f\u65f6\u95f4\u670d\u7528\u89c4\u5b9a\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fbe\u53ef\u66ff\u5c3c\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u4e3a\u8179\u6cfb\u3001\u76ae\u75b9\u3001\u7532\u6c9f\u708e\u3001\u53e3\u8154\u9ecf\u819c\u708e\u3001\u76ae\u80a4\u5e72\u71e5\u7b49\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u7279\u522b\u5173\u6ce8\u95f4\u8d28\u6027\u80ba\u708e\u7684\u53d1\u751f\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u51fa\u73b0\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u6839\u636e\u60a3\u8005\u7684\u8010\u53d7\u6027\uff0c\u4ee5\u6bcf\u6b21\u51cf\u91cf<span>15mg<\/span>\u7684\u65b9\u5f0f\u9010\u6b65\u964d\u4f4e\u672c\u54c1\u7684\u5242\u91cf\uff1a\uff08<span>1<\/span>\uff09\u9996\u6b21\u51cf\u91cf\u81f3<span>30mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u3002\uff08<span>2<\/span>\uff09\u7b2c\u4e8c\u6b21\u51cf\u91cf\u81f3<span>15mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u3002\u5982\u679c\u60a3\u8005\u4e0d\u8010\u53d7<span>15mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u7684\u7ed9\u836f\u5242\u91cf\uff0c\u5e94\u8be5\u6c38\u4e45\u505c\u7528\u3002\u5728\u547c\u5438\u7cfb\u7edf\u75c7\u72b6\u6076\u5316\u4e14\u53ef\u80fd\u9884\u793a\u95f4\u8d28\u6027\u80ba\u708e\uff08\u4f8b\u5982\u547c\u5438\u56f0\u96be\u3001\u54b3\u55fd\u548c\u53d1\u70ed\uff09\u7684\u60a3\u8005\u4e2d\u6682\u65f6\u505c\u7528\u672c\u54c1\u5e76\u7acb\u5373\u8fdb\u884c\u95f4\u8d28\u6027\u80ba\u708e\u7684\u8bca\u65ad\u3002\u5982\u679c\u786e\u8bca\u4e3a\u4efb\u4f55\u7ea7\u522b\u7684\u95f4\u8d28\u6027\u80ba\u708e\uff0c\u5219\u6c38\u4e45\u505c\u7528\u672c\u54c1\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u5efa\u8bae\u5bf9\u8f7b\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u6216\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u7684\u60a3\u8005\u8c03\u6574\u5242\u91cf\u3002\u5c1a\u672a\u786e\u5b9a\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u672c\u54c1\u63a8\u8350\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u670d\u7528\u672c\u54c1\u65f6\uff0c\u907f\u514d\u540c\u65f6\u4f7f\u7528\u8d28\u5b50\u6cf5\u6291\u5236\u5242\u3002\u53ef\u4f7f\u7528\u5c40\u90e8\u4f5c\u7528\u7684\u6297\u9178\u5242\u6216<span>H<sub>2<\/sub><\/span>\u53d7\u4f53\u62ee\u6297\u5242\u4ee3\u66ff\u8d28\u5b50\u6cf5\u6291\u5236\u5242\uff1b\u5fc5\u987b\u4e34\u65f6\u670d\u7528<span>H<sub>2<\/sub><\/span>\u53d7\u4f53\u62ee\u6297\u5242\u7684\u60c5\u51b5\u4e0b\uff0c\u81f3\u5c11\u63d0\u524d<span>6<\/span>\u5c0f\u65f6\u6216\u6ede\u540e<span>10<\/span>\u5c0f\u65f6\u540e\u7ed9\u4e88\u672c\u54c1\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u670d\u7528\u672c\u54c1\u65f6\uff0c\u907f\u514d\u540c\u65f6\u4f7f\u7528<span>CYP2D6<\/span>\u5e95\u7269\uff0c\u56e0\u4e3a<span>CYP2D6<\/span>\u5e95\u7269\u6d53\u5ea6\u7565\u5fae\u589e\u52a0\u53ef\u80fd\u4ea7\u751f\u4e25\u91cd\u7684\u6216\u5371\u53ca\u751f\u547d\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u516d\u3001<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5965\u5e0c\u66ff\u5c3c<span> Osimertinib<\/span><\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>40mg<\/span>\u3001<span>80mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u2160<span>B<\/span>\uff5e\u2162<span>A<\/span>\u671f<span>EGFR<\/span>\u57fa\u56e0\u5916\u663e\u5b50<span>19<\/span>\u7f3a\u5931\u6216<span>21<\/span>\u5916\u663e\u5b50<span>L858R<\/span>\u7f6e\u6362\u7a81\u53d8\u7684<span>NSCLC<\/span>\u60a3\u8005\u7684\u672f\u540e\u8f85\u52a9\u6cbb\u7597\uff0c\u5e76\u7531\u533b\u751f\u51b3\u5b9a\u63a5\u53d7\u6216\u4e0d\u63a5\u53d7\u8f85\u52a9\u5316\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5177\u6709<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">EGFR19<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5916\u663e\u5b50\u7f3a\u5931\u7a81\u53d8\u6216<span>21<\/span>\u5916\u663e\u5b50<span>L858R<\/span>\u7f6e\u6362\u7a81\u53d8<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u6210\u4eba\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u7ecf<span>EGFR-TKI<\/span>\u6cbb\u7597\u65f6\u6216\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\uff0c\u5e76\u4e14\u7ecf\u68c0\u6d4b\u786e\u8ba4\u5b58\u5728<span>EGFR-T790M<\/span>\u7a81\u53d8\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u6210\u4eba\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672f\u540e\u8f85\u52a9\u7528\u836f\u6216\u4e00\u7ebf\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684<span>EGFR<\/span>\u57fa\u56e0\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230\u7684<span>EGFR19<\/span>\u5916\u663e\u5b50\u7f3a\u5931\u7a81\u53d8\u6216<span>21<\/span>\u5916\u663e\u5b50<span>L858R<\/span>\u7f6e\u6362\u7a81\u53d8\u9633\u6027\u7684\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u65e2\u5f80\u7ecf<span>EGFR-TKI<\/span>\u6cbb\u7597\u65f6\u6216\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u60a3\u8005\uff0c\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230<span>EGFR-T790M<\/span>\u7a81\u53d8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.EGFR<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u56e0\u654f\u611f\u7a81\u53d8\u7684\u2160<span>B<\/span>\uff5e<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2162<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">A<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u671f<span>NSCLC<\/span>\u60a3\u8005\u5b8c\u5168\u80bf\u7624\u5207\u9664\u672f\u540e\u63a8\u8350<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5965\u5e0c\u66ff\u5c3c<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f85\u52a9\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.EGFR<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7a81\u53d8\u9633\u6027\u7684\u8111\u8f6c\u79fb\u6216\u8111\u819c\u8f6c\u79fb\u60a3\u8005\u63a8\u8350\u4f18\u5148\u4f7f\u7528\u5965\u5e0c\u66ff\u5c3c\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5965\u5e0c\u66ff\u5c3c\u63a8\u8350\u5242\u91cf\u4e3a<span>80mg<\/span>\u53e3\u670d\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u8fdb\u9910\u6216\u7a7a\u8179\u65f6\u670d\u7528\u5747\u53ef\u3002\u6839\u636e\u60a3\u8005\u4e2a\u4f53\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u6682\u505c\u7528\u836f\u6216\u51cf\u91cf\u3002\u5982\u679c\u9700\u8981\u51cf\u91cf\uff0c\u5219\u5242\u91cf\u5e94\u51cf\u81f3<span>40mg<\/span>\u53e3\u670d\uff0c\u6bcf\u5929\u4e00\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u76ae\u80a4\u53cd\u5e94\u548c\u8179\u6cfb\uff0c\u9700\u6ce8\u610f\u5fc3\u7535\u56fe<span>QTc<\/span>\u95f4\u671f\u5ef6\u957f\uff0c\u5e94\u7279\u522b\u6ce8\u610f\u95f4\u8d28\u6027\u80ba\u708e\u7684\u53d1\u751f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u4e0e<span>CYP3A4<\/span>\u5f3a\u8bf1\u5bfc\u5242\u3001\u4e73\u817a\u764c\u8010\u836f\u86cb\u767d\u5e95\u7269\u4ee5\u53ca<span>P-<\/span>\u7cd6\u86cb\u767d\u5e95\u7269\u8054\u5408\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e03<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u3001\u963f\u7f8e\u66ff\u5c3c<span> Almonertinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>55mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u7ecf<span>EGFR-TKI<\/span>\u6cbb\u7597\u65f6\u6216\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\uff0c\u5e76\u4e14\u7ecf\u68c0\u6d4b\u786e\u8ba4\u5b58\u5728<span>EGFR-T790M<\/span>\u7a81\u53d8\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u6210\u4eba\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u7f8e\u66ff\u5c3c\u63a8\u8350\u5242\u91cf\u4e3a<span>110mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u53e3\u670d\uff0c\u7a7a\u8179\u6216\u9910\u540e\u670d\u7528\u5747\u53ef\uff0c\u6574\u7247\u541e\u670d\uff0c\u4e0d\u8981\u5480\u56bc\u6216\u538b\u788e\u3002\u5bf9\u4e8e\u65e0\u6cd5\u6574\u7247\u541e\u54bd\u836f\u7269\u548c\u9700\u7ecf\u9f3b\u80c3\u7ba1\u5582\u9972\u7684\u60a3\u8005\uff0c\u53ef\u5c06\u836f\u7247\u76f4\u63a5\u6eb6\u4e8e\u4e0d\u542b\u78b3\u9178\u76d0\u7684\u996e\u7528\u6c34\u4e2d\u5b8c\u5168\u5206\u6563\u540e\u670d\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230<span>EGFR-T790M<\/span>\u7a81\u53d8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u7f8e\u66ff\u5c3c\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u4e3a\u76ae\u75b9\u3001\u8840\u808c\u9178\u78f7\u9178\u6fc0\u9176\u5347\u9ad8\u548c\u7619\u75d2\u7b49\uff0c\u8179\u6cfb\u7684\u53d1\u751f\u7387\u76f8\u5bf9\u8f83\u4f4e\u3002\u63a8\u8350\u5242\u91cf\u4e0b\u8fc4\u4eca\u65e0\u95f4\u8d28\u6027\u80ba\u708e\u7684\u53d1\u751f\uff0c\u4f46\u4ecd\u9700\u5728\u670d\u836f\u671f\u95f4\u6ce8\u610f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u4e0e<span>CYP3A4<\/span>\u5f3a\u8bf1\u5bfc\u5242\u548c\u5f3a\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\uff0c\u5e94\u614e\u7528\u4e73\u817a\u764c\u8010\u836f\u86cb\u767d\u548c<span>P-<\/span>\u7cd6\u86cb\u767d\u654f\u611f\u5e95\u7269\u7684\u7a84\u6cbb\u7597\u7a97\u836f\u7269\u3002\u907f\u514d\u4e0e\u5347\u9ad8\u8840\u808c\u9178\u78f7\u9178\u6fc0\u9176\u7684\u836f\u7269\uff08\u5982\u4ed6\u6c40\u7c7b\u836f\u7269\uff09\u8054\u5408\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u516b\u3001\u4f0f\u7f8e\u66ff\u5c3c<span> Furmonertinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff0c<span>40mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u7ecf<span>EGFR-TKI<\/span>\u6cbb\u7597\u65f6\u6216\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\uff0c\u5e76\u4e14\u7ecf\u68c0\u6d4b\u786e\u8ba4\u5b58\u5728<span>EGFR-T790M<\/span>\u7a81\u53d8\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u6210\u4eba\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230<span>EGFR-T790M<\/span>\u7a81\u53d8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a<span>80mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u7a7a\u8179\u53e3\u670d\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0f\u7f8e\u66ff\u5c3c\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u4e3a\u4e19\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08<span>ALT<\/span>\uff09\u548c<span>\/<\/span>\u6216\u5929\u95e8\u51ac\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08<span>AST<\/span>\uff09\u5347\u9ad8\u3001\u5fc3\u7535\u56fe<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">QTc<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u95f4\u671f\u5ef6\u957f\u3002\u9700\u8b66\u60d5\u95f4\u8d28\u6027\u80ba\u708e\u7684\u53d1\u751f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u4e0e<span>CYP3A4<\/span>\u5f3a\u8bf1\u5bfc\u5242\u6216\u5f3a\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e5d\u3001<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u514b\u5511\u66ff\u5c3c<span> Crizotinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>200mg<\/span>\u3001<span>250mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08<span>ALK<\/span>\uff09\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.ROS1<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9633\u6027\u7684\u665a\u671f<span>NSCLC<\/span>\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230\u7684<span>ROS1<\/span>\u9633\u6027\u6216\u8005<span>ALK<\/span>\u9633\u6027\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u809d\u529f\u80fd\u5f02\u5e38\u548c\u89c6\u89c9\u5f02\u5e38\uff0c\u5728\u6cbb\u7597\u5f00\u59cb\u7684\u6700\u521d\u4e24\u4e2a\u6708\u5e94\u6bcf\u5468\u68c0\u6d4b\u4e00\u6b21\uff0c\u4e4b\u540e\u6bcf\u6708\u68c0\u6d4b\u4e00\u6b21\u60a3\u8005\u7684\u809d\u529f\u80fd\uff0c\u809d\u635f\u4f24\u60a3\u8005\u5e94\u8c28\u614e\u4f7f\u7528\u514b\u5511\u66ff\u5c3c\u8fdb\u884c\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a<span>250mg<\/span>\u53e3\u670d\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u4e0e\u98df\u7269\u540c\u670d\u6216\u4e0d\u540c\u670d\u3002\u5982\u679c\u51fa\u73b0<span>CTCAE<\/span>\uff08<span>4.0<\/span>\u7248\uff09<span>3<\/span>\u7ea7\u6216<span>4<\/span>\u7ea7\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0c\u9700\u6309\u4ee5\u4e0b\u65b9\u6cd5\u51cf\u5c11\u5242\u91cf\uff1a\uff08<span>1<\/span>\uff09\u7b2c\u4e00\u6b21\u51cf\u5c11\u5242\u91cf\uff1a\u53e3\u670d\uff0c<span>200mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u3002\uff08<span>2<\/span>\uff09\u7b2c\u4e8c\u6b21\u51cf\u5c11\u5242\u91cf\uff1a\u53e3\u670d\uff0c<span>250mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff1b\u5982\u679c\u6bcf\u5929\u4e00\u6b21\u53e3\u670d<span>250mg<\/span>\u514b\u5511\u66ff\u5c3c\u80f6\u56ca\u4ecd\u65e0\u6cd5\u8010\u53d7\uff0c\u5219\u6c38\u4e45\u505c\u670d\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u907f\u514d\u5408\u5e76\u4f7f\u7528<span>CYP3A<\/span>\u5f3a\u6291\u5236\u5242\u6216<span>CYP3A<\/span>\u5f3a\u8bf1\u5bfc\u5242\uff0c\u5982\u679c\u65e0\u6cd5\u907f\u514d\u5408\u5e76\u4f7f\u7528<span>CYP3A<\/span>\u5f3a\u6291\u5236\u5242\uff0c\u5e94\u51cf\u5c11\u514b\u5511\u66ff\u5c3c\u7684\u5242\u91cf\u3002\u5e94\u8c28\u614e\u4e0e\u4e2d\u5ea6<span>CYP3A<\/span>\u6291\u5236\u5242\u5408\u5e76\u7528\u836f\u3002\u514b\u5511\u66ff\u5c3c\u80f6\u56ca\u53ef\u5ef6\u957f<span>QTc<\/span>\u95f4\u671f\uff0c\u907f\u514d\u5408\u5e76\u4f7f\u7528\u53ef\u5ef6\u957f<span>QTc<\/span>\u95f4\u671f\u7684\u836f\u7269\u3002\u514b\u5511\u66ff\u5c3c\u80f6\u56ca\u53ef\u5f15\u8d77\u5fc3\u52a8\u8fc7\u7f13\uff0c\u907f\u514d\u5408\u5e76\u4f7f\u7528\u53ef\u5f15\u8d77\u5fc3\u52a8\u8fc7\u7f13\u7684\u836f\u7269\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u4e8e<span>Profile1001<\/span>\u7814\u7a76\u7ed3\u679c\u548c<span>2021<\/span>\u7248<span>NCCN<\/span>\u6307\u5357\uff0c\u514b\u5511\u66ff\u5c3c\u9002\u7528\u4e8e<span>cMET14<\/span>\u5916\u663e\u5b50\u8df3\u8dc3\u7a81\u53d8\u7684\u665a\u671f<span>NSCLC<\/span>\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5341\u3001\u963f\u6765\u66ff\u5c3c<span> Alectinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>150mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">ALK<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u60a3\u8005\u7528\u836f\u524d\u5fc5\u987b\u83b7\u5f97\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u8bc1\u5b9e\u7684<span>ALK<\/span>\u9633\u6027\u7ed3\u679c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u60a3\u8005\u63a5\u53d7\u672c\u836f\u7269\u6cbb\u7597\u76f4\u5230\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u65e0\u6cd5\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a<span>600mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u968f\u9910\u53e3\u670d\u3002\u5982\u51fa\u73b0\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5e94\u6839\u636e\u60a3\u8005\u8010\u53d7\u6027\uff0c\u4ee5\u6bcf\u6b21\u51cf\u91cf<span>150mg<\/span>\u7684\u65b9\u5f0f\u9010\u6b65\u964d\u4f4e\u672c\u54c1\u7684\u5242\u91cf\uff1a\uff08<span>1<\/span>\uff09\u9996\u6b21\u51cf\u91cf\uff1a<span>450mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u3002\uff08<span>2<\/span>\uff09\u7b2c\u4e8c\u6b21\u51cf\u91cf\uff1a<span>300mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\uff1b\u5982\u679c\u60a3\u8005\u4e0d\u80fd\u8010\u53d7<span>300mg<\/span>\u6bcf\u5929\u4e24\u6b21\u7684\u7ed9\u836f\u5242\u91cf\uff0c\u5e94\u8be5\u6c38\u4e45\u505c\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u57fa\u7ebf\u65f6\u5e94\u76d1\u6d4b\u809d\u529f\u80fd\uff0c\u5305\u62ec<span>ALT<\/span>\u3001<span>AST<\/span>\u548c\u603b\u80c6\u7ea2\u7d20\uff0c\u5728\u6700\u521d\u6cbb\u7597\u7684<span>3<\/span>\u4e2a\u6708\u5185\u6bcf\u4e24\u5468\u76d1\u6d4b\u4e00\u6b21\uff0c\u4e4b\u540e\u5b9a\u671f\u8fdb\u884c\u76d1\u6d4b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u60a3\u8005\u62a5\u544a\u4efb\u4f55\u539f\u56e0\u4e0d\u660e\u7684\u808c\u75db\u3001\u89e6\u75db\u6216\u865a\u5f31\uff0c\u8bc4\u4f30\u808c\u9178\u78f7\u9178\u6fc0\u9176\u6c34\u5e73\uff0c\u5728\u7b2c\u4e00\u4e2a\u6708\u6cbb\u7597\u671f\u95f4\u6bcf\u4e24\u5468\u8bc4\u4f30\u4e00\u6b21\uff0c\u968f\u540e\u5728\u4e34\u5e8a\u4e0a\u6839\u636e\u60a3\u8005\u62a5\u544a\u7684\u75c7\u72b6\u6309\u9700\u8fdb\u884c\u8bc4\u4f30\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u786e\u8bca\u60a3\u6709\u95f4\u8d28\u6027\u80ba\u708e<span>\/<\/span>\u975e\u611f\u67d3\u6027\u80ba\u708e\u7684\u60a3\u8005\u5e94\u7acb\u5373\u4e2d\u65ad\u672c\u54c1\u6cbb\u7597\uff0c\u5982\u679c\u6ca1\u6709\u53d1\u73b0\u5176\u4ed6\u95f4\u8d28\u6027\u80ba\u708e<span>\/<\/span>\u975e\u611f\u67d3\u6027\u80ba\u708e\u7684\u6f5c\u5728\u75c5\u56e0\uff0c\u5219\u5e94\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5728\u670d\u7528\u963f\u6765\u66ff\u5c3c\u65f6\u53ca\u6cbb\u7597\u505c\u6b62\u540e\u81f3\u5c11<span>7<\/span>\u5929\u5185\uff0c\u5e94\u5efa\u8bae\u60a3\u8005\u907f\u514d\u957f\u65f6\u95f4\u9633\u5149\u66b4\u6652\u3002\u6b64\u5916\uff0c\u5e94\u5efa\u8bae\u60a3\u8005\u4f7f\u7528\u9632\u7d2b\u5916\u7ebf<span>A<\/span>\uff08<span>UVA<\/span>\uff09<span>\/<\/span>\u7d2b\u5916\u7ebf<span>B<\/span>\uff08<span>UVB<\/span>\uff09\u7684\u5e7f\u8c31\u9632\u6652\u971c\u548c\u6da6\u5507\u818f\uff08<span>SPF<\/span>\u2265<span>50<\/span>\uff09\uff0c\u9632\u6b62\u53ef\u80fd\u7684\u6652\u4f24\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5e94\u6839\u636e\u4e34\u5e8a\u6307\u5f81\u76d1\u6d4b\u5fc3\u7387\u548c\u8840\u538b\u3002\u5982\u679c\u53d1\u751f\u65e0\u75c7\u72b6\u5fc3\u52a8\u8fc7\u7f13\uff0c\u5219\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff1b\u5982\u679c\u60a3\u8005\u53d1\u751f\u75c7\u72b6\u6027\u5fc3\u52a8\u8fc7\u7f13\u6216\u5371\u53ca\u751f\u547d\u7684\u4e8b\u4ef6\uff0c\u5e94\u5bf9\u5408\u5e76\u7528\u836f\u4e2d\u5df2\u77e5\u5f15\u53d1\u5fc3\u52a8\u8fc7\u7f13\u7684\u836f\u7269\uff08\u5982\u964d\u538b\u836f\uff09\u8fdb\u884c\u8bc4\u4f30\uff0c\u5e76\u4f9d\u636e\u8bf4\u660e\u4e66\u8c03\u6574\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5f53\u963f\u6765\u66ff\u5c3c\u4e0e\u6cbb\u7597\u6307\u6570\u72ed\u7a84\u7684<span>P-<\/span>\u7cd6\u86cb\u767d\u6216\u4e73\u817a\u764c\u8010\u836f\u86cb\u767d\u5e95\u7269\uff08\u5982\u5730\u9ad8\u8f9b\u3001\u8fbe\u6bd4\u52a0\u7fa4\u3001\u7532\u6c28\u8776\u5464\uff09\u5408\u5e76\u7528\u836f\u65f6\uff0c\u5efa\u8bae\u8fdb\u884c\u9002\u5f53\u7684\u76d1\u6d4b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u963f\u6765\u66ff\u5c3c\u4e0e<span>CYP3A<\/span>\u8bf1\u5bfc\u5242\u6216\u6291\u5236\u5242\u5408\u5e76\u7528\u836f\u65f6\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e00\u3001\u585e\u745e\u66ff\u5c3c<span> Ceritinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>150mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">ALK<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230\u7684<span>ALK<\/span>\u9633\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u7684\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u5929\u4e00\u6b21\uff0c<span>450mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u5728\u540c\u4e00\u65f6\u95f4\u53e3\u670d\u7ed9\u836f\uff0c\u836f\u7269\u5e94\u4e0e\u98df\u7269\u540c\u65f6\u670d\u7528\u3002\u6839\u636e\u60a3\u8005\u4e2a\u4f53\u7684\u5b89\u5168\u6027\u6216\u8010\u53d7\u6027\uff0c\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u53ef\u80fd\u9700\u8981\u6682\u65f6\u4e2d\u65ad\u4f7f\u7528\u672c\u54c1\u6216\u4e0b\u8c03\u5242\u91cf\uff0c\u5e94\u4ee5<span>150mg<\/span>\u7684\u4e0b\u8c03\u5e45\u5ea6\u9010\u6e10\u51cf\u5c11\u672c\u54c1\u7684\u65e5\u5242\u91cf\u3002\u5e94\u6ce8\u610f\u65e9\u671f\u8bc6\u522b\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u5e76\u53ca\u65e9\u7ed9\u4e88\u6807\u51c6\u7684\u652f\u6301\u6027\u6cbb\u7597\u63aa\u65bd\u3002\u5bf9\u4e8e\u65e0\u6cd5\u8010\u53d7\u6bcf\u5929\u968f\u9910\u670d\u7528<span>150mg<\/span>\u5242\u91cf\u7684\u60a3\u8005\uff0c\u5e94\u505c\u7528\u672c\u54c1\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u987b\u6ce8\u610f\u80c3\u80a0\u9053\u4e0d\u826f\u53cd\u5e94\u3001\u809d\u6bd2\u6027\u3001\u95f4\u8d28\u6027\u80ba\u708e<span>\/<\/span>\u975e\u611f\u67d3\u6027\u80ba\u708e\u3001\u5fc3\u5f8b\u5931\u5e38\u3001\u9ad8\u8840\u7cd6\u7b49\u4e0d\u826f\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u5e94\u907f\u514d\u8054\u5408\u4f7f\u7528\u5f3a\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\u3002\u5982\u679c\u5fc5\u987b\u540c\u65f6\u4f7f\u7528\u5f3a\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\uff08\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u5229\u6258\u90a3\u97e6\u3001\u6c99\u594e\u90a3\u97e6\u3001\u6cf0\u5229\u9709\u7d20\u3001\u916e\u5eb7\u5511\u3001\u4f0a\u66f2\u5eb7\u5511\u3001\u4f0f\u7acb\u5eb7\u5511\u3001\u6cca\u6c99\u5eb7\u5511\u3001\u5948\u6cd5\u5511\u916e\uff09\u65e0\u6cd5\u907f\u514d\uff0c\u5219\u5e94\u5c06\u585e\u745e\u66ff\u5c3c\u7684\u5242\u91cf\u51cf\u5c11\u7ea6\u4e09\u5206\u4e4b\u4e00\uff0c\u5e76\u8fd1\u4f3c\u4e3a<span>150mg<\/span>\u5242\u91cf\u89c4\u683c\u7684\u500d\u6570\u3002\u5f53\u505c\u6b62\u7ed9\u4e88<span>CYP3A<\/span>\u6291\u5236\u5242\u540e\uff0c\u6062\u590d\u4f7f\u7528\u5f3a<span>CYP3A<\/span>\u6291\u5236\u5242\u4e4b\u524d\u7684\u7ed9\u836f\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f53\u5916\u7814\u7a76\u6570\u636e\u663e\u793a\uff0c\u672c\u54c1\u662f\u5916\u6392\u578b\u8f6c\u8fd0\u86cb\u767d<span>P-<\/span>\u7cd6\u86cb\u767d\u7684\u5e95\u7269\u3002\u5982\u679c\u672c\u54c1\u4e0e\u6291\u5236<span>P-<\/span>\u7cd6\u86cb\u767d\u7684\u836f\u7269\u8054\u5408\u4f7f\u7528\uff0c\u53ef\u80fd\u5bfc\u81f4\u672c\u54c1\u6d53\u5ea6\u5347\u9ad8\u3002\u8054\u5408\u4f7f\u7528<span>P-<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\u65f6\u5e94\u8c28\u614e\uff0c\u5e76\u5c0f\u5fc3\u76d1\u6d4b\u4e0d\u826f\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u4e8e\u4e00\u9879\u53d1\u8868\u4e8e<span>JCO<\/span>\u7684\u2161\u671f\u4e34\u5e8a\u7814\u7a76\uff08<span>NCT01964157<\/span>\uff09\uff0c\u5728\u7ecf\u5316\u7597\u6cbb\u7597\u540e\u7684<span>ROS1<\/span>\u91cd\u6392\u7684<span>NSCLC<\/span>\u60a3\u8005\u53ef\u9009\u62e9\u585e\u745e\u66ff\u5c3c\u8fdb\u884c\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e8c\u3001\u6069\u6c99\u66ff\u5c3c <span>Ensartinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u786c\u80f6\u56ca\u5242\uff1a<span>25mg<\/span>\u3001<span>100mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u6b64\u524d\u63a5\u53d7\u8fc7\u514b\u5511\u66ff\u5c3c\u6cbb\u7597\u540e\u8fdb\u5c55\u7684\u6216\u8005\u5bf9\u514b\u5511\u66ff\u5c3c\u4e0d\u8010\u53d7\u7684<span>ALK<\/span>\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230\u7684<span>ALK<\/span>\u9633\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u5929\u4e00\u6b21\uff0c\u6bcf\u6b21<span>225mg<\/span>\uff0c\u6bcf\u5929\u5728\u540c\u4e00\u65f6\u95f4\u53e3\u670d\u7ed9\u836f\uff0c\u7a7a\u8179\u6216\u4e0e\u98df\u7269\u540c\u670d\u3002\u5982\u679c\u6f0f\u670d<span>1<\/span>\u6b21\uff0c\u4e14\u8ddd\u4e0b\u6b21\u670d\u836f\u65f6\u95f4\u95f4\u9694<span>12<\/span>\u5c0f\u65f6\u4ee5\u4e0a\uff0c\u60a3\u8005\u5e94\u8865\u670d\u6f0f\u670d\u7684\u5242\u91cf\u3002\u82e5\u6cbb\u7597\u671f\u95f4\u53d1\u751f\u5455\u5410\uff0c\u60a3\u8005\u4e0d\u5e94\u670d\u7528\u989d\u5916\u5242\u91cf\uff0c\u4f46\u5e94\u7ee7\u7eed\u670d\u7528\u4e0b\u6b21\u8ba1\u5212\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u82e5\u672c\u54c1\u5e94\u7528\u4e2d\u51fa\u73b0<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u9700\u8981\u8c03\u6574\u5242\u91cf\u53ef\u53c2\u8003\u5982\u4e0b\u539f\u5219\uff1a\u672c\u54c1\u8d77\u59cb\u5242\u91cf\u4e3a<span>225mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff1b\u9996\u6b21\u51cf\u91cf\u8c03\u6574\u4e3a<span>200mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff1b\u82e5\u4ecd\u4e0d\u80fd\u8010\u53d7\uff0c\u518d\u4e00\u6b21\u51cf\u91cf\u8c03\u6574\u4e3a<span>150mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff1b<span>150mg<\/span>\u6bcf\u5929\u4e00\u6b21\u4ecd\u65e0\u6cd5\u8010\u53d7\uff0c\u5e94\u505c\u7528\u672c\u54c1\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u4e3b\u8981\u4e0d\u826f\u53cd\u5e94\u4e3a\u4e00\u8fc7\u6027\u836f\u75b9\uff0c\u4e3b\u8981\u8868\u73b0\u4e3a<span>1<\/span>\uff5e<span>2<\/span>\u7ea7\u76ae\u75b9\u548c\u7619\u75d2\u75c7\uff0c\u60a3\u8005\u53d1\u751f\u76ae\u75b9\u4e2d\u4f4d\u6301\u7eed\u65f6\u95f4\u4e3a<span>21.5<\/span>\u5929\u3002\u9664\u76ae\u75b9\u5916\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u4e3a<span>1<\/span>\uff5e<span>2<\/span>\u7ea7<span>ALT\/AST<\/span>\u5347\u9ad8\uff0c\u4ee5\u53ca<span>1<\/span>\uff5e<span>2<\/span>\u7ea7\u80c3\u80a0\u9053\u4e0d\u9002\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u4e0e<span>CYP3A4<\/span>\u5f3a\u8bf1\u5bfc\u5242\u6216\u5f3a\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e09\u3001<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297<span> Bevacizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>4ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408\u4ee5\u94c2\u7c7b\u4e3a\u57fa\u7840\u7684\u5316\u7597\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u7684\u665a\u671f\u3001\u8f6c\u79fb\u6027\u6216\u590d\u53d1\u6027\u975e\u9cde\u72b6\u7ec6\u80de<span>NSCLC<\/span>\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297\u4e0d\u9002\u7528\u4e8e\u665a\u671f\u80ba\u9cde\u72b6\u7ec6\u80de\u764c\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u4e25\u91cd\u51fa\u8840\u6216\u8005\u8fd1\u671f\u66fe\u6709\u54af\u8840\u3001\u80bf\u7624\u4fb5\u72af\u5927\u8840\u7ba1\u7684\u60a3\u8005\u4e0d\u5e94\u63a5\u53d7\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408\u4ee5\u94c2\u7c7b\u4e3a\u57fa\u7840\u7684\u5316\u7597\u6700\u591a<span>6<\/span>\u4e2a\u5468\u671f\uff0c\u968f\u540e\u7ed9\u4e88\u8d1d\u4f10\u73e0\u5355\u6297\u5355\u836f\u7ef4\u6301\u6cbb\u7597\u6216\u4e0e\u53ef\u7528\u4e8e\u7ef4\u6301\u6cbb\u7597\u7684\u5316\u7597\u836f\u7269\u5982\u57f9\u7f8e\u66f2\u585e\u8054\u5408\u7ef4\u6301\u6cbb\u7597\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297\u63a8\u8350\u5242\u91cf\u4e3a<span>15mg\/kg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\u3002\u4e5f\u53ef\u4ee5\u4f7f\u7528<span>7.5mg\/kg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51fa\u73b0\u4ee5\u4e0b\u60c5\u51b5\uff0c\u505c\u6b62\u4f7f\u7528\u8d1d\u4f10\u73e0\u5355\u6297\uff1a<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08<span>1<\/span>\uff09<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e25\u91cd\u80c3\u80a0\u9053\u4e0d\u826f\u53cd\u5e94\uff08\u80c3\u80a0\u9053\u7a7f\u5b54\u3001\u80c3\u80a0\u9053\u7618\u5f62\u6210\u3001\u8179\u8154\u8113\u80bf\uff09\uff0c\u5185\u810f\u7618\u5f62\u6210\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08<span>2<\/span>\uff09<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9700\u8981\u5e72\u9884\u6cbb\u7597\u7684\u4f24\u53e3\u88c2\u5f00\u4ee5\u53ca\u4f24\u53e3\u6108\u5408\u5e76\u53d1\u75c7\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08<span>3<\/span>\uff09<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u91cd\u5ea6\u51fa\u8840\uff08\u4f8b\u5982\u9700\u8981\u5e72\u9884\u6cbb\u7597\uff09<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u3002\uff08<span>4<\/span>\uff09<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u91cd\u5ea6\u52a8\u8109\u8840\u6813\u4e8b\u4ef6\u3002\uff08<span>5<\/span>\uff09\u5371\u53ca\u751f\u547d\uff08<span>4<\/span>\u7ea7\uff09\u7684\u9759\u8109\u8840\u6813\u6813\u585e\u4e8b\u4ef6\uff0c\u5305\u62ec\u80ba\u6813\u585e\u3002\uff08<span>6<\/span>\uff09\u9ad8\u8840\u538b\u5371\u8c61\u6216\u9ad8\u8840\u538b\u8111\u75c5\u3002\uff08<span>7<\/span>\uff09\u53ef\u9006\u6027\u540e\u90e8\u8111\u75c5\u7efc\u5408\u5f81\u3002\uff08<span>8<\/span>\uff09\u80be\u75c5\u7efc\u5408\u5f81\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u51fa\u73b0\u4ee5\u4e0b\u72b6\u51b5\uff0c\u9700\u6682\u505c\u4f7f\u7528\u8d1d\u4f10\u73e0\u5355\u6297\uff1a\uff08<span>1<\/span>\uff09\u62e9\u671f\u624b\u672f\u524d<span>4<\/span>\uff5e<span>6<\/span>\u5468\uff0c\u624b\u672f\u540e\u81f3\u5c11<span>28<\/span>\u5929\u53ca\u4f24\u53e3\u5b8c\u5168\u6062\u590d\u4e4b\u524d\u3002\uff08<span>2<\/span>\uff09\u836f\u7269\u63a7\u5236\u4e0d\u826f\u7684\u91cd\u5ea6\u9ad8\u8840\u538b\u3002\uff08<span>3<\/span>\uff09\u4e2d\u5ea6\u5230\u91cd\u5ea6\u7684\u86cb\u767d\u5c3f\u9700\u8981\u8fdb\u4e00\u6b65\u8bc4\u4f30\u3002\uff08<span>4<\/span>\uff09\u91cd\u5ea6\u8f93\u6db2\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u6b27\u76df\uff0c\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408\u5384\u6d1b\u66ff\u5c3c\u83b7\u6279\u7528\u4e8e<span>EGFR<\/span>\u57fa\u56e0\u5177\u6709\u654f\u611f\u7a81\u53d8\u7684\u3001\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u665a\u671f\u3001\u8f6c\u79fb\u6027\u6216\u590d\u53d1\u6027\u975e\u9cde\u72b6<span>NSCLC<\/span>\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\uff0c\u76ee\u524d\u56fd\u5185\u5c1a\u672a\u83b7\u6279\u6b64\u9002\u5e94\u8bc1\uff0c\u53ef\u5728\u4e0e\u60a3\u8005\u5145\u5206\u6c9f\u901a\u7684\u60c5\u51b5\u4e0b\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u56db\u3001\u91cd\u7ec4\u4eba\u8840\u7ba1\u5185\u76ae\u6291\u5236\u7d20<span> Endostatin<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9488\u5242\uff1a<span>15mg<\/span>\uff08<span>3ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u8054\u5408\u957f\u6625\u745e\u6ee8<span>\/<\/span>\u987a\u94c2\uff08<span>NP<\/span>\uff09\u5316\u7597\u65b9\u6848\u7528\u4e8e\u6cbb\u7597\u521d\u6cbb\u6216\u590d\u6cbb\u7684\u2162\uff5e\u2163\u671f<span>NSCLC<\/span>\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u91cd\u7ec4\u4eba\u8840\u7ba1\u5185\u76ae\u6291\u5236\u7d20\u4e0e<span>NP<\/span>\u65b9\u6848\u8054\u5408\u81f3<span>4<\/span>\u4e2a\u5468\u671f\uff0c\u7136\u540e\u91c7\u7528\u672c\u54c1\u8fdb\u884c\u7ef4\u6301\u6cbb\u7597\u3002\u672c\u54c1\u9002\u7528\u4e8e\u521d\u6cbb\u6216\u590d\u6cbb\u7684\u2162\uff5e\u2163\u671f<span>NSCLC<\/span>\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u51fa\u73b0\u4ee5\u4e0b\u72b6\u51b5\uff0c\u9700\u6682\u505c\u4f7f\u7528\u91cd\u7ec4\u4eba\u8840\u7ba1\u5185\u76ae\u6291\u5236\u7d20\uff1a\uff08<span>1<\/span>\uff09\u51fa\u73b0\u76f8\u5173\u5fc3\u810f\u6bd2\u6027\u53cd\u5e94\u65f6\uff0c\u5982\u2265<span>3<\/span>\u7ea7\u6216\u2264<span>2<\/span>\u7ea7\u4e14\u6bd2\u6027\u53cd\u5e94\u6301\u7eed\u5b58\u5728\u3002\uff08<span>2<\/span>\uff09\u2265<span>3<\/span>\u7ea7\u76ae\u80a4\u8fc7\u654f\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u91cd\u7ec4\u4eba\u8840\u7ba1\u5185\u76ae\u6291\u5236\u7d20\u4e3b\u8981\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\uff1a\u57fa\u4e8e\u2163\u671f\u7814\u7a76\u7ed3\u679c\uff0c\u53d1\u751f\u7387\u5206\u522b\u4e3a\uff1a\u5fc3\u5f8b\u5931\u5e38\uff08<span>0.7%<\/span>\uff09\u3001\u5fc3\u529f\u80fd\u4e0b\u964d\uff08<span>0.2%<\/span>\uff09\u3001\u51fa\u8840\uff08<span>0.4%<\/span>\uff09\u3001\u8fc7\u654f\u53cd\u5e94\uff08<span>0.2%<\/span>\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fc7\u654f\u4f53\u8d28\u6216\u5bf9\u86cb\u767d\u7c7b\u751f\u7269\u5236\u54c1\u6709\u8fc7\u654f\u53f2\u8005\u614e\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u4e25\u91cd\u5fc3\u810f\u75c5\u6216\u75c5\u53f2\u8005\u614e\u7528\uff0c\u672c\u54c1\u4e34\u5e8a\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u5e94\u5b9a\u671f\u68c0\u6d4b\u5fc3\u7535\u56fe\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e94\u3001<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c<span> Anlotinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>8mg<\/span>\u3001<span>10mg<\/span>\u3001<span>12mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5355\u836f\u9002\u7528\u4e8e\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7<span>2<\/span>\u79cd\u7cfb\u7edf\u5316\u7597\u540e\u51fa\u73b0\u8fdb\u5c55\u6216\u590d\u53d1\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u60a3\u8005\u7684\u6cbb\u7597\u3002\u5bf9\u4e8e\u5b58\u5728<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u6216<span>ALK<\/span>\u9633\u6027\u7684\u60a3\u8005\uff0c\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u5e94\u63a5\u53d7\u76f8\u5e94\u7684\u9776\u5411\u836f\u7269\u6cbb\u7597\u540e\u8fdb\u5c55\u3001\u4e14\u81f3\u5c11\u63a5\u53d7\u8fc7<span>2<\/span>\u79cd\u7cfb\u7edf\u5316\u7597\u540e\u51fa\u73b0\u8fdb\u5c55\u6216\u590d\u53d1\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5355\u836f\u9002\u7528\u4e8e\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7<span>2<\/span>\u79cd\u5316\u7597\u65b9\u6848\u6cbb\u7597\u540e\u8fdb\u5c55\u6216\u590d\u53d1\u7684\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f7f\u7528\u5b89\u7f57\u66ff\u5c3c\u524d\u65e0\u9700\u8fdb\u884c\u57fa\u56e0\u68c0\u6d4b\uff0c\u4f46\u5bf9\u4e8e\u5b58\u5728<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u6216<span>ALK<\/span>\u878d\u5408\u9633\u6027\u7684\u60a3\u8005\uff0c\u5728\u5f00\u59cb\u5b89\u7f57\u66ff\u5c3c\u6cbb\u7597\u524d\u5e94\u63a5\u53d7\u76f8\u5e94\u7684\u6807\u51c6\u9776\u5411\u836f\u7269\u6cbb\u7597\u540e\u8fdb\u5c55\u3001\u4e14\u81f3\u5c11\u63a5\u53d7\u8fc7<span>2<\/span>\u79cd\u7cfb\u7edf\u5316\u7597\u540e\u51fa\u73b0\u8fdb\u5c55\u6216\u590d\u53d1\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e2d\u592e\u578b\u80ba\u9cde\u72b6\u7ec6\u80de\u764c\u6216\u5177\u6709\u5927\u54af\u8840\u98ce\u9669\u7684\u60a3\u8005\u3001\u91cd\u5ea6\u809d\u80be\u529f\u80fd\u635f\u4f24\u7684\u60a3\u8005\u7981\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c\u6709\u589e\u52a0\u53d1\u751f\u51fa\u8840\u4e8b\u4ef6\u548c\u53d1\u751f\u8840\u6813<span>\/<\/span>\u6813\u585e\u4e8b\u4ef6\u7684\u98ce\u9669\uff0c\u56e0\u6b64\uff0c\u5177\u6709\u51fa\u8840\u98ce\u9669\u3001\u51dd\u8840\u529f\u80fd\u5f02\u5e38\u7684\u60a3\u8005\u3001\u5177\u6709\u8840\u6813<span>\/<\/span>\u5352\u4e2d\u75c5\u53f2\u7684\u60a3\u8005\u4ee5\u53ca\u670d\u7528\u6297\u51dd\u836f\u7269\u53ca\u76f8\u5173\u75be\u75c5\u7684\u60a3\u8005\u5e94\u614e\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u6b21<span>12mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u65e9\u9910\u524d\u53e3\u670d\uff0c\u8fde\u7eed\u670d\u836f<span>2<\/span>\u5468\uff0c\u505c\u836f<span>1<\/span>\u5468\uff0c\u5373<span>3<\/span>\u5468\u4e3a\u4e00\u4e2a\u7597\u7a0b\u3002\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u8981\u5bc6\u5207\u76d1\u6d4b\u4e0d\u826f\u53cd\u5e94\uff0c\u5e76\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7a0b\u5ea6\uff0c\u5728\u533b\u5e08\u6307\u5bfc\u4e0b\u8c03\u6574\u5242\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5e94\u5bc6\u5207\u5173\u6ce8\u9ad8\u8840\u538b\u7684\u53d1\u751f\uff0c\u5e38\u89c4\u964d\u538b\u836f\u7269\u53ef\u6709\u6548\u63a7\u5236\u60a3\u8005\u8840\u538b\uff0c\u5982\u567b\u55ea\u7c7b\u5229\u5c3f\u5242\uff0c\u8840\u7ba1\u7d27\u5f20\u7d20\u8f6c\u6362\u9176\u6291\u5236\u5242\uff08<span>ACEI<\/span>\uff09\u7b49\uff08\u9274\u4e8e\u836f\u7269\u76f8\u4e92\u4f5c\u7528\uff0c\u5bf9<span>ACEI<\/span>\u7c7b\u4e0d\u80fd\u63a7\u5236\u7684\u9ad8\u8840\u538b\u53ef\u914c\u60c5\u9009\u62e9\u9499\u79bb\u5b50\u62ee\u6297\u5242\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u4e0e<span>CYP1A2<\/span>\u548c<span>CYP3A4<\/span>\u7684\u5f3a\u6291\u5236\u5242\u548c\u5f3a\u8bf1\u5bfc\u5242\u8054\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5341\u516d\u3001\u4f9d\u7ef4\u83ab\u53f8<span>Everolimus<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>2.5mg<\/span>\u3001<span>5mg<\/span>\u3001<span>10mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u65e0\u6cd5\u624b\u672f\u5207\u9664\u7684\u3001\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u7684\u3001\u5206\u5316\u826f\u597d\u7684\u3001\u8fdb\u5c55\u671f\u975e\u529f\u80fd\u6027\u80c3\u80a0\u9053\u6216\u80ba\u6e90\u795e\u7ecf\u5185\u5206\u6ccc\u7624\u6210\u4eba\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>10mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u53e3\u670d\u7ed9\u836f\uff0c\u5728\u6bcf\u5929\u540c\u4e00\u65f6\u95f4\u670d\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u7528\u4e00\u676f\u6c34\u6574\u7247\u9001\u670d\u672c\u54c1\u7247\u5242\uff0c\u4e0d\u5e94\u5480\u56bc\u6216\u538b\u788e\u3002\u5bf9\u4e8e\u65e0\u6cd5\u541e\u54bd\u7247\u5242\u7684\u60a3\u8005\uff0c\u7528\u836f\u524d\u5c06\u672c\u54c1\u7247\u5242\u653e\u5165\u4e00\u676f\u6c34\u4e2d\uff08\u7ea6<span>30ml<\/span>\uff09\u8f7b\u8f7b\u6405\u62cc\u81f3\u5b8c\u5168\u6eb6\u89e3\uff08\u5927\u7ea6\u9700\u8981<span>7<\/span>\u5206\u949f\uff09\u540e\u7acb\u5373\u670d\u7528\u3002\u7528\u76f8\u540c\u5bb9\u91cf\u7684\u6c34\u6e05\u6d17\u6c34\u676f\u5e76\u5c06\u6e05\u6d17\u6db2\u5168\u90e8\u670d\u7528\uff0c\u4ee5\u786e\u4fdd\u670d\u7528\u4e86\u5b8c\u6574\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u53ea\u8981\u5b58\u5728\u4e34\u5e8a\u83b7\u76ca\u5c31\u5e94\u6301\u7eed\u6cbb\u7597\uff0c\u6216\u4f7f\u7528\u81f3\u51fa\u73b0\u4e0d\u80fd\u8010\u53d7\u7684\u6bd2\u6027\u53cd\u5e94\u65f6\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5728\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u6ca1\u6709\u8fdb\u884c\u672c\u54c1\u7684\u4e34\u5e8a\u7814\u7a76\u3002\u9884\u671f\u80be\u529f\u80fd\u635f\u4f24\u4e0d\u4f1a\u5f71\u54cd\u836f\u7269\u66b4\u9732\uff0c\u5728\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u4e0d\u63a8\u8350\u8c03\u6574\u4f9d\u7ef4\u83ab\u53f8\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5177\u6709\u514d\u75ab\u6291\u5236\u6027\uff0c\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u5e94\u5f7b\u5e95\u6cbb\u7597\u5df2\u7ecf\u5b58\u5728\u7684\u4fb5\u5165\u6027\u771f\u83cc\u611f\u67d3\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5bf9\u672c\u54c1\u6709\u6548\u6210\u5206\u3001\u5176\u4ed6\u96f7\u5e15\u9709\u7d20\u884d\u751f\u7269\u6216\u672c\u54c1\u4e2d\u4efb\u4f55\u8f85\u6599\u8fc7\u654f\u8005\u7981\u7528\u3002\u5728\u4f7f\u7528\u4f9d\u7ef4\u83ab\u53f8\u548c\u5176\u4ed6\u96f7\u5e15\u9709\u7d20\u884d\u751f\u7269\u60a3\u8005\u4e2d\u5df2\u89c2\u5bdf\u5230\u7684\u8fc7\u654f\u53cd\u5e94\u8868\u73b0\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\uff1a\u8fc7\u654f\u3001\u547c\u5438\u56f0\u96be\u3001\u6f6e\u7ea2\u3001\u80f8\u75db\u6216\u8840\u7ba1\u6027\u6c34\u80bf\uff08\u4f8b\u5982\uff0c\u4f34\u6216\u4e0d\u4f34\u547c\u5438\u529f\u80fd\u4e0d\u5168\u7684\u6c14\u9053\u6216\u820c\u80bf\u80c0\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u53e3\u8154\u708e\u5305\u62ec\u53e3\u8154\u6e83\u75a1\u548c\u53e3\u8154\u9ecf\u819c\u708e\u3002\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u53d1\u751f\u7387\u4e3a<span>44%<\/span>\uff5e<span>86%<\/span>\uff0c<span>4%<\/span>\uff5e<span>9%<\/span>\u7684\u60a3\u8005\u62a5\u544a\u4e86<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u53e3\u8154\u708e\u3002\u53e3\u8154\u708e\u5927\u90e8\u5206\u5728\u6cbb\u7597\u7684\u524d<span>8<\/span>\u5468\u5185\u53d1\u751f\u3002\u5982\u679c\u53d1\u751f\u53e3\u8154\u708e\uff0c\u5efa\u8bae\u4f7f\u7528\u5c40\u90e8\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u907f\u514d\u8054\u7528<span>CYP3A4<\/span>\u5f3a\u6548\u6291\u5236\u5242\u548c\u8bf1\u5bfc\u5242\u4ee5\u53ca<span>P-<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\u3002\u5408\u7528\u4e2d\u6548<span>CYP3A4<\/span>\u548c<span>\/<\/span>\u6216<span>P-<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\u5e94\u5c06\u4f9d\u7ef4\u83ab\u53f8\u5242\u91cf\u964d\u4f4e\u5927\u7ea6<span>50%<\/span>\uff1b\u5982\u9700\u4f7f\u7528\u5f3a<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u7684\u5ba4\u7ba1\u819c\u4e0b\u5de8\u7ec6\u80de\u661f\u5f62\u7ec6\u80de\u7624\u60a3\u8005\u5728\u5f00\u59cb\u6cbb\u7597\u65f6\u53ef\u80fd\u9700\u8981\u589e\u52a0\u672c\u54c1\u7684\u5242\u91cf\u4ee5\u8fbe\u5230\u8c37\u6d53\u5ea6<span>5<\/span>\uff5e<span>15ng\/ml<\/span>\u3002\u5c06\u672c\u54c1\u7684\u65e5\u5242\u91cf\u7ffb\u500d\u5e76\u8bc4\u4f30\u8010\u53d7\u6027\u3002\u5728\u5242\u91cf\u7ffb\u500d\u7684\u5927\u7ea6<span>2<\/span>\u5468\u540e\u8bc4\u4f30\u4f9d\u7ef4\u83ab\u53f8\u8c37\u6d53\u5ea6\u3002\u5fc5\u8981\u65f6\u6309\u589e\u5e45<span>1<\/span>\uff5e<span>4mg<\/span>\u8fdb\u4e00\u6b65\u8c03\u6574\u5242\u91cf\u4ee5\u7ef4\u6301\u8c37\u6d53\u5ea6\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e03\u3001\u666e\u62c9\u66ff\u5c3c<span> Pralsetinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>100mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u63a5\u53d7\u8fc7\u542b\u94c2\u5316\u7597\u7684\u8f6c\u67d3\u91cd\u6392\uff08<span>RET<\/span>\uff09\u57fa\u56e0\u878d\u5408\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u6210\u4eba\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u5145\u5206\u9a8c\u8bc1\u7684\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230<span>RET<\/span>\u57fa\u56e0\u878d\u5408\u9633\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u5929<span>400mg<\/span>\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u65e0\u6cd5\u8010\u53d7\u7684\u6bd2\u6027\u3002\u5e94\u5728\u6bcf\u5929\u76f8\u540c\u7684\u65f6\u95f4\u670d\u7528\uff0c\u7a7a\u8179\u72b6\u6001\u4e0b\u53e3\u670d\uff0c\u5373\u670d\u7528\u672c\u54c1\u524d\u81f3\u5c11<span>2<\/span>\u5c0f\u65f6\u4ee5\u53ca\u670d\u7528\u672c\u54c1\u540e\u81f3\u5c11<span>1<\/span>\u5c0f\u65f6\u8bf7\u52ff\u8fdb\u98df\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u6f0f\u670d\uff0c\u5e94\u5728\u5f53\u5929\u5c3d\u5feb\u8865\u670d\u3002\u5728\u7b2c\u4e8c\u5929\u91cd\u65b0\u6062\u590d\u672c\u54c1\u7684\u5e38\u89c4\u65e5\u5242\u91cf\u670d\u836f\u8ba1\u5212\u3002\u82e5\u5728\u670d\u836f\u540e\u53d1\u751f\u5455\u5410\u8bf7\u52ff\u8865\u670d\u989d\u5916\u5242\u91cf\uff0c\u4f46\u53ef\u6309\u8ba1\u5212\u7ee7\u7eed\u670d\u7528\u4e0b\u4e2a\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u51fa\u73b0\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u6839\u636e\u60a3\u8005\u7684\u8010\u53d7\u6027\uff0c\u4ee5\u6bcf\u6b21\u51cf\u91cf<span>100mg<\/span>\u7684\u65b9\u5f0f\u9010\u6b65\u964d\u4f4e\u672c\u54c1\u7684\u5242\u91cf\uff1a\uff08<span>1<\/span>\uff09\u9996\u6b21\u51cf\u91cf\u81f3<span>300mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u3002\uff08<span>2<\/span>\uff09\u7b2c\u4e8c\u6b21\u51cf\u91cf\u81f3<span>200mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u3002\uff08<span>3<\/span>\uff09\u7b2c\u4e09\u6b21\u51cf\u91cf\u81f3<span>100mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u3002\u5982\u679c\u60a3\u8005\u4e0d\u8010\u53d7<span>100mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u7684\u7ed9\u836f\u5242\u91cf\uff0c\u5e94\u8be5\u6c38\u4e45\u505c\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u53d1\u751f\u7387\u2265<span>25%<\/span>\uff09\u4e3a\u4fbf\u79d8\u3001\u9ad8\u8840\u538b\u3001\u75b2\u4e4f\u3001\u9aa8\u9abc\u808c\u8089\u75bc\u75db\u548c\u8179\u6cfb\u3002\u6700\u5e38\u89c1\u7684<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u7ed3\u679c\u5f02\u5e38\uff08\u53d1\u751f\u7387\u2265<span>2%<\/span>\uff09\u4e3a\u6dcb\u5df4\u7ec6\u80de\u964d\u4f4e\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u964d\u4f4e\u3001\u8840\u7ea2\u86cb\u767d\u964d\u4f4e\u3001\u78f7\u9178\u76d0\u964d\u4f4e\u3001\u9499\u964d\u4f4e\uff08\u6821\u6b63\uff09\u3001\u8840\u94a0\u964d\u4f4e\u3001<span>AST<\/span>\u5347\u9ad8\u3001<span>ALT<\/span>\u5347\u9ad8\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u548c\u78b1\u6027\u78f7\u9178\u9176\u5347\u9ad8\u3002\u5e94\u7279\u522b\u6ce8\u610f\u975e\u611f\u67d3\u6027\u80ba\u708e<span>\/<\/span>\u95f4\u8d28\u6027\u80ba\u708e\u53d1\u751f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u4e0e\u5f3a\u6548\u7684<span>P-<\/span>\u7cd6\u86cb\u767d\u548c<span>CYP3A<\/span>\u5171\u540c\u6291\u5236\u5242\u53ca<span>CYP3A<\/span>\u6291\u5236\u5242\u6216\u8bf1\u5bfc\u5242\uff08\u5982\u4f0f\u7acb\u5eb7\u5511\u3001\u82ef\u59a5\u82f1\u3001\u5361\u9a6c\u897f\u5e73\u3001\u5229\u798f\u5e73\u7b49\uff09\u8054\u5408\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u516b\u3001\u8d5b\u6c83\u66ff\u5c3c<span> Savolitinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>100mg<\/span>\u3001<span>200mg <\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d5b\u6c83\u66ff\u5c3c\u7528\u4e8e\u542b\u94c2\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u8010\u53d7\u6807\u51c6\u542b\u94c2\u5316\u7597\u7684\u3001\u5177\u6709\u95f4\u8d28<span>&#8211;<\/span>\u4e0a\u76ae\u8f6c\u5316\u56e0\u5b50\uff08<span>MET<\/span>\uff09\u5916\u663e\u5b50<span>14<\/span>\u8df3\u8dc3\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u6210\u4eba\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u6709\u7ecf\u5145\u5206\u9a8c\u8bc1\u7684\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230<span>MET<\/span>\u5916\u663e\u5b50<span>14<\/span>\u8df3\u8dc3\u7a81\u53d8\u3002\u5bf9\u4e8e\u80ba\u8089\u7624\u6837\u764c\uff0c\u66f4\u5e94\u6ce8\u610f\u68c0\u6d4b<span>MET<\/span>\u5916\u663e\u5b50<span>14<\/span>\u8df3\u8dc3\u7a81\u53d8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u4f53\u91cd\u2265<span>50kg<\/span>\u7684\u60a3\u8005\uff0c\u5efa\u8bae\u8d5b\u6c83\u66ff\u5c3c\u8d77\u59cb\u5242\u91cf\u4e3a<span>600mg<\/span>\uff0c\u5bf9\u4e8e\u4f53\u91cd\uff1c<span>50kg<\/span>\u7684\u60a3\u8005\uff0c\u5efa\u8bae\u8d77\u59cb\u5242\u91cf\u4e3a<span>400mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u53e3\u670d\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u60a3\u8005\u4e2a\u4f53\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u8c03\u6574\u7528\u836f\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<table class=\"MsoNormalTable\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"100%\" style=\"width:100.0%;border-collapse:collapse;border:none;\">\n<tbody>\n<tr>\n<td width=\"100%\" colspan=\"3\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"center\" style=\"margin-left:0cm;text-align:center;\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8868<span>3<\/span>&emsp;\u8d5b\u6c83\u66ff\u5c3c\u5242\u91cf\u8c03\u6574\u5efa\u8bae<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"36%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u6c34\u5e73<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"63%\" colspan=\"2\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d5b\u6c83\u66ff\u5c3c\u6bcf\u5929\u53e3\u670d\u5242\u91cf<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"36%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d77\u59cb\u5242\u91cf<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"31%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">600mg<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6bcf\u5929\u4e00\u6b21<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08\u4f53\u91cd<span>\u226550kg<\/span>\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"31%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">400mg<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6bcf\u5929\u4e00\u6b21<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08\u4f53\u91cd\uff1c<span>50kg<\/span>\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"36%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u6c34\u5e73<span>-1<\/span>\uff08\u7b2c\u4e00\u6b21\u51cf\u91cf\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"31%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">400mg<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6bcf\u5929\u4e00\u6b21<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"31%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">300mg<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6bcf\u5929\u4e00\u6b21<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"36%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u6c34\u5e73<span>-2<\/span>\uff08\u7b2c\u4e8c\u6b21\u51cf\u91cf\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"31%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">300mg<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6bcf\u5929\u4e00\u6b21<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"31%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">200mg<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6bcf\u5929\u4e00\u6b21<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"36%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u6c34\u5e73<span>-3<\/span>\uff08\u7b2c\u4e09\u6b21\u51cf\u91cf\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"31%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">200mg<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6bcf\u5929\u4e00\u6b21<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"31%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">&#8211;<\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u9700\u6ce8\u610f\u809d\u6bd2\u6027\u3001\u53d1\u70ed\u3001\u6c34\u80bf\u4ee5\u53ca\u8d85\u654f\u53cd\u5e94\u7684\u53d1\u751f\u3002\u53d1\u751f\u7387\u2265<span>10%<\/span>\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a\u6076\u5fc3\u3001\u6c34\u80bf\u3001\u75b2\u4e4f<span>\/<\/span>\u4e4f\u529b\u3001\u5455\u5410\u3001\u98df\u6b32\u51cf\u9000\u3001\u4f4e\u767d\u86cb\u767d\u8840\u75c7\u3001\u8d2b\u8840\u3001\u53d1\u70ed\u3001\u8179\u6cfb\uff0c\u4ee5\u53ca<span>AST<\/span>\u5347\u9ad8\u548c<span>ALT<\/span>\u5347\u9ad8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u907f\u514d\u548c<span>CYP3A4<\/span>\u7684\u5f3a\u8bf1\u5bfc\u5242\uff08\u5982\u82ef\u59a5\u82f1\u3001\u5229\u798f\u5e73\u548c\u5361\u9a6c\u897f\u5e73\uff09\u540c\u65f6\u4f7f\u7528\uff0c\u5e94\u8c28\u614e\u6216\u5c3d\u53ef\u80fd\u907f\u514d\u4e0e<span>CYP3A4<\/span>\u4e2d\u5ea6\u8bf1\u5bfc\u5242\uff08\u5982\u6ce2\u751f\u5766\u3001\u4f9d\u6cd5\u97e6\u4ed1\u3001\u4f9d\u66f2\u97e6\u6797\u548c\u83ab\u8fbe\u975e\u5c3c\uff09\u5408\u7528\u3002\u5bf9\u4e8e\u8d2f\u53f6\u8fde\u7fd8\uff08<span>St.John&#8217;s Wort<\/span>\uff09\u53ca\u5176\u63d0\u53d6\u7269\u5e94\u5728\u672c\u54c1\u670d\u7528\u524d<span>3<\/span>\u5468\u7981\u670d\u3002\u5e94\u614e\u7528\u4e8c\u7532\u53cc\u80cd\uff0c\u5e76\u76d1\u6d4b\u7531\u4e8e\u4e8c\u7532\u53cc\u80cd\u66b4\u9732\u91cf\u589e\u52a0\u53ef\u80fd\u5e26\u6765\u7684\u98ce\u9669\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e5d\u3001\u7eb3\u6b66\u5229\u5c24\u5355\u6297<span> Nivolumab<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:26.6pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a\u6ce8\u5c04\u6db2\uff1a<span>40mg<\/span>\uff08<span>4ml<\/span>\uff09<span>\/<\/span>\u74f6\u3001<span>100mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5355\u836f\u9002\u7528\u4e8e\u6cbb\u7597<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c<span>ALK<\/span>\u9634\u6027\u3001\u65e2\u5f80\u63a5\u53d7\u8fc7\u542b\u94c2\u65b9\u6848\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u6210\u4eba\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\u7528\u4e8e\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u3001\u521d\u6cbb\u7684\u975e\u4e0a\u76ae\u6837\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u6210\u4eba\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u6210\u4eba\u60a3\u8005\uff0c\u65e2\u5f80\u63a5\u53d7\u8fc7\u542b\u94c2\u65b9\u6848\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u60a3\u8005\u5fc5\u987b\u4e3a<span>EGFR<\/span>\u9634\u6027\u548c<span>ALK<\/span>\u9634\u6027\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53ea\u8981\u89c2\u5bdf\u5230\u4e34\u5e8a\u83b7\u76ca\uff0c\u5e94\u7ee7\u7eed\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\uff0c\u76f4\u81f3\u60a3\u8005\u4e0d\u80fd\u8010\u53d7\uff0c\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\uff08\u4f8b\u5982\u6700\u521d\u51e0\u4e2a\u6708\u5185\u80bf\u7624\u6682\u65f6\u589e\u5927\u6216\u51fa\u73b0\u65b0\u7684\u5c0f\u75c5\u7076\uff0c\u968f\u540e\u80bf\u7624\u7f29\u5c0f\uff09\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u5728\u4e2d\u56fd\u57fa\u4e8e<span>CheckMate 078<\/span>\u7814\u7a76\uff0c\u5355\u836f\u4f7f\u7528\u83b7\u6279\u7684\u5242\u91cf\u662f<span>3mg\/kg<\/span>\u6216<span>240mg<\/span>\u56fa\u5b9a\u5242\u91cf\uff0c\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff0c<span>30<\/span>\u5206\u949f\u8f93\u6ce8\u3002\u5728\u6b27\u7f8e\uff0c\u57fa\u4e8e<span>PPK<\/span>\u7814\u7a76\uff0c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u5df2\u7ecf\u83b7\u6279\u56fa\u5b9a\u5242\u91cf\uff0c<span>480mg<\/span>\u3001\u6bcf<span>4<\/span>\u5468\u4e00\u6b21\u6216\u8005<span>240mg<\/span>\u3001\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff0c<span>30<\/span>\u5206\u949f\u8f93\u6ce8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u53ef\u91c7\u7528<span>10mg\/ml <\/span>\u6eb6\u6db2\u76f4\u63a5\u8f93\u6ce8\uff0c\u6216\u8005\u91c7\u7528\u6ce8\u5c04\u7528\u6c2f\u5316\u94a0\u6eb6\u6db2\uff08<span>9mg\/ml<\/span>\uff0c<span>0.9%<\/span>\uff09\u6216\u6ce8\u5c04\u7528\u8461\u8404\u7cd6\u6eb6\u6db2\uff08<span>50mg\/ml<\/span>\uff0c<span>5%<\/span>\uff09\u7a00\u91ca\uff0c\u6d53\u5ea6\u53ef\u4f4e\u81f3<span>1mg\/ml<\/span>\u3002\u603b\u8f93\u6ce8\u91cf\u4e00\u5b9a\u4e0d\u80fd\u8d85\u8fc7<span>160ml<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0e\u4f0a\u5339\u6728\u5355\u6297\u8054\u5408\u6cbb\u7597\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u63a8\u8350\u5242\u91cf\u4e3a<span>360mg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c\u6216<span>3mg\/kg<\/span>\uff0c\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff0c\u9759\u8109\u8f93\u6ce8<span>30<\/span>\u5206\u949f\uff0c\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297<span>1mg\/kg<\/span>\uff0c\u6bcf<span>6<\/span>\u5468\u4e00\u6b21\uff0c\u9759\u8109\u8f93\u6ce8<span>30<\/span>\u5206\u949f\u3002\u5bf9\u4e8e\u6ca1\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u60a3\u8005\uff0c\u6cbb\u7597\u6301\u7eed\u6700\u957f\u81f3<span>24<\/span>\u4e2a\u6708\u3002\u4e0e\u4f0a\u5339\u6728\u5355\u6297\u8054\u7528\u65f6\uff0c\u5e94\u5148\u8f93\u6ce8\u672c\u54c1\uff0c\u4e4b\u540e\u540c\u4e00\u5929\u8f93\u6ce8\u4f0a\u5339\u6728\u5355\u6297\u3002\u6bcf\u6b21\u8f93\u6ce8\u9700\u4f7f\u7528\u5355\u72ec\u7684\u8f93\u6db2\u888b\u548c\u8fc7\u6ee4\u5668\uff0c\u8f93\u6ce8\u7ed3\u675f\u65f6\u51b2\u6d17\u8f93\u6db2\u7ba1\uff0c\u8bf7\u52ff\u901a\u8fc7\u540c\u4e00\u6839\u8f93\u6db2\u7ba1\u540c\u65f6\u7ed9\u4e88\u5176\u4ed6\u836f\u7269\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;color:red;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u6682\u505c\u7ed9\u836f\u6216\u505c\u836f\u3002\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53d1\u751f<span>4<\/span>\u7ea7\u6216\u590d\u53d1\u6027<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u867d\u7136\u8fdb\u884c\u6cbb\u7597\u8c03\u6574\u4f46\u4ecd\u6301\u7eed\u5b58\u5728<span>2<\/span>\u7ea7\u6216<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u6c38\u4e45\u6027\u505c\u7528\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8001\u5e74\u60a3\u8005\uff08\u2265<span>65<\/span>\u5c81\uff09\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u6570\u636e\u6709\u9650\u3002\u8f7b\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u6ca1\u6709\u5bf9\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u8fdb\u884c\u672c\u54c1\u7684\u76f8\u5173\u7814\u7a76\uff0c\u91cd\u5ea6\uff08\u603b\u80c6\u7ea2\u7d20\u3001<span>ALT<\/span>\u6216<span>AST<\/span>\uff1e<span>3<\/span>\u500d\u6b63\u5e38\u503c\u4e0a\u9650\uff09\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5fc5\u987b\u614e\u7528\u672c\u54c1\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u53ef\u5f15\u8d77\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u3002\u56e0\u4e3a\u4e0d\u826f\u53cd\u5e94\u53ef\u80fd\u5728\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u671f\u95f4\u6216\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u505c\u6b62\u540e\u7684\u4efb\u4f55\u65f6\u95f4\u53d1\u751f\uff0c\u5e94\u6301\u7eed\u8fdb\u884c\u60a3\u8005\u76d1\u6d4b\uff08\u81f3\u5c11\u81f3\u672b\u6b21\u7ed9\u836f\u540e<span>5<\/span>\u4e2a\u6708\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">12.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u5e94\u6682\u505c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u5e76\u7ed9\u4e88\u7cd6\u76ae\u8d28\u6fc0\u7d20\u3002\u82e5\u4f7f\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u514d\u75ab\u6291\u5236\u7597\u6cd5\u6cbb\u7597\u4e0d\u826f\u53cd\u5e94\uff0c\u75c7\u72b6\u6539\u5584\u540e\uff0c\u9700\u81f3\u5c11<span>1<\/span>\u4e2a\u6708\u7684\u65f6\u95f4\u9010\u6e10\u51cf\u91cf\u81f3\u505c\u836f\u3002\u5feb\u901f\u51cf\u91cf\u53ef\u80fd\u5f15\u8d77\u4e0d\u826f\u53cd\u5e94\u6076\u5316\u6216\u590d\u53d1\u3002\u5982\u679c\u4f7f\u7528\u4e86\u7cd6\u76ae\u8d28\u6fc0\u7d20\u4f46\u4ecd\u6076\u5316\u6216\u65e0\u6539\u5584\uff0c\u5219\u5e94\u589e\u52a0\u975e\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6027\u514d\u75ab\u6291\u5236\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">13.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u60a3\u8005\u63a5\u53d7\u514d\u75ab\u6291\u5236\u5242\u91cf\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u6cbb\u7597\u671f\u95f4\uff0c\u4e0d\u53ef\u91cd\u65b0\u4f7f\u7528\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">14.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u51fa\u73b0\u4efb\u4f55\u91cd\u5ea6\u3001\u590d\u53d1\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u4ee5\u53ca\u4efb\u4f55\u5371\u53ca\u751f\u547d\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5fc5\u987b\u6c38\u4e45\u505c\u6b62\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">15.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6ce8\u5c04\u6db2\u6bcf\u6beb\u5347\u542b<span>0.1mmol<\/span>\uff08\u6216<span>2.5mg<\/span>\uff09\u94a0\uff0c\u5728\u5bf9\u63a7\u5236\u94a0\u6444\u5165\u7684\u60a3\u8005\u8fdb\u884c\u6cbb\u7597\u65f6\u5e94\u8003\u8651\u8fd9\u4e00\u56e0\u7d20\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">16.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u662f\u4e00\u79cd\u4eba\u5355\u514b\u9686\u6297\u4f53\uff0c\u56e0\u5355\u514b\u9686\u6297\u4f53\u4e0d\u7ecf<span>CYP450<\/span>\u6216\u5176\u4ed6\u836f\u7269\u4ee3\u8c22\u9176\u4ee3\u8c22\uff0c\u56e0\u6b64\uff0c\u5408\u5e76\u4f7f\u7528\u7684\u836f\u7269\u5bf9\u8fd9\u4e9b\u9176\u7684\u6291\u5236\u6216\u8bf1\u5bfc\u4f5c\u7528\u9884\u671f\u4e0d\u4f1a\u5f71\u54cd\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u6027\u8d28\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">17.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5f53\u672c\u54c1\u4e0e\u4f0a\u5339\u6728\u5355\u6297\u8054\u5408\u6cbb\u7597\u65f6\uff0c\u82e5\u6682\u505c\u4efb\u4e00\u836f\u7269\uff0c\u5219\u5e94\u540c\u65f6\u6682\u505c\u53e6\u4e00\u836f\u7269\u3002\u82e5\u5728\u6682\u505c\u540e\u91cd\u65b0\u5f00\u59cb\u7ed9\u836f\uff0c\u5219\u5e94\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u8bc4\u4f30\u60c5\u51b5\u91cd\u65b0\u5f00\u59cb\u8054\u5408\u6cbb\u7597\u6216\u672c\u54c1\u5355\u836f\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">18.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7f8e\u56fd<span>FDA<\/span>\u6279\u51c6\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u80bf\u7624<span>PD-L1<\/span>\u8868\u8fbe\u9633\u6027\uff08\u5b9a\u4e49\u4e3a\u8868\u8fbe<span>PD-L1<\/span>\u7684\u80bf\u7624\u7ec6\u80de\u2265<span>1%<\/span>\uff09\u3001<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c<span>ALK<\/span>\u9634\u6027\u3001\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\uff0c\u76ee\u524d\u56fd\u5185\u5c1a\u672a\u83b7\u6279\u6b64\u9002\u5e94\u8bc1\uff0c\u53ef\u5728\u4e0e\u60a3\u8005\u5145\u5206\u6c9f\u901a\u7684\u60c5\u51b5\u4e0b\u4f7f\u7528\u3002\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u7528\u6cd5\u4e3a<span>3mg\/kg<\/span>\uff0c\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff1b\u4f0a\u5339\u6728\u5355\u6297\u7528\u6cd5\u4e3a<span>1mg\/kg<\/span>\uff0c\u6bcf<span>6<\/span>\u5468\u4e00\u6b21\u3002\u6b64\u5916\uff0c\u7f8e\u56fd<span>FDA<\/span>\u548c\u6b27\u76df<span>EMA<\/span>\u8fd8\u6279\u51c6\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\u548c\u4e24\u5468\u671f\u542b\u94c2\u53cc\u836f\u5316\u7597\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c<span>ALK<\/span>\u9634\u6027\u3001\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\uff0c\u76ee\u524d\u56fd\u5185\u5c1a\u672a\u83b7\u6279\u6b64\u9002\u5e94\u8bc1\uff0c\u53ef\u5728\u4e0e\u60a3\u8005\u5145\u5206\u6c9f\u901a\u7684\u60c5\u51b5\u4e0b\u4f7f\u7528\u3002\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u7528\u6cd5\u4e3a<span>360mg<\/span>\u56fa\u5b9a\u5242\u91cf\uff0c\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff1b\u4f0a\u5339\u6728\u5355\u6297\u7528\u6cd5\u4e3a<span>1mg\/kg<\/span>\uff0c\u6bcf<span>6<\/span>\u5468\u4e00\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u3001\u5e15\u535a\u5229\u73e0\u5355\u6297<span> Pembrolizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>4ml<\/span>\uff09<span>\/<\/span>\u74f6 <span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u94c2\u7c7b\u5316\u7597\u836f\u9002\u7528\u4e8e<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c<span>ALK<\/span>\u9634\u6027\u7684\u8f6c\u79fb\u6027\u975e\u9cde\u72b6<span>NSCLC<\/span>\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u9002\u7528\u4e8e\u7531\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u8bc4\u4f30\u4e3a<span>PD-L1<\/span>\u80bf\u7624\u6bd4\u4f8b\u5206\u6570\uff08<span>TPS<\/span>\uff09\u2265<span>1%<\/span>\u7684<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c<span>ALK<\/span>\u9634\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u4e00\u7ebf\u5355\u836f\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u5361\u94c2\u548c\u7d2b\u6749\u9187\u9002\u7528\u4e8e\u8f6c\u79fb\u6027\u9cde\u72b6<span>NSCLC<\/span>\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53ea\u8981\u89c2\u5bdf\u5230\u4e34\u5e8a\u83b7\u76ca\uff0c\u5e94\u7ee7\u7eed\u4f7f\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u53d1\u751f\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\uff0c\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u4f46\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u9996\u4e2a\u4e00\u7ebf\u80ba\u764c\u9002\u5e94\u8bc1\u662f\u57fa\u4e8e\u5168\u7403\u2162\u671f\u4e34\u5e8a\u7814\u7a76<span>KEYNOTE-189<\/span>\u7814\u7a76\u7ed3\u679c\uff0c\u5728\u4e2d\u56fd\u83b7\u6279\u7684\u80ba\u764c\u9002\u5e94\u8bc1\u5242\u91cf\u662f<span>200mg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c\u6216<span>400mg<\/span>\uff0c\u6bcf<span>6<\/span>\u5468\u4e00\u6b21\uff0c\u901a\u8fc7\u9759\u8109\u8f93\u6ce8\u7ed9\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u4f7f\u7528\u672c\u54c1\u4e4b\u524d\u5e94\u907f\u514d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u836f\u7269\u53ef\u80fd\u4f1a\u5f71\u54cd\u672c\u54c1\u7684\u836f\u6548\u5b66\u6d3b\u6027\u53ca\u7597\u6548\u3002\u4f46\u5728\u672c\u54c1\u5f00\u59cb\u7ed9\u836f\u540e\uff0c\u53ef\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u514d\u75ab\u4ecb\u5bfc\u6027\u4e0d\u826f\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u505c\u836f\uff0c\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53d1\u751f<span>4<\/span>\u7ea7\u6216\u590d\u53d1\u6027<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u867d\u7136\u8fdb\u884c\u6cbb\u7597\u8c03\u6574\u4f46\u4ecd\u6301\u7eed\u5b58\u5728<span>2<\/span>\u7ea7\u6216<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u6c38\u4e45\u6027\u505c\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8001\u5e74\u60a3\u8005\uff08\u2265<span>65<\/span>\u5c81\uff09\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u6570\u636e\u6709\u9650\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u5c1a\u672a\u5728\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u8fdb\u884c\u672c\u54c1\u7684\u76f8\u5173\u7814\u7a76\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u53ef\u5f15\u8d77\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u3002\u56e0\u4e3a\u4e0d\u826f\u53cd\u5e94\u53ef\u80fd\u5728\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u671f\u95f4\u6216\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u505c\u6b62\u540e\u7684\u4efb\u4f55\u65f6\u95f4\u53d1\u751f\uff0c\u5e94\u6301\u7eed\u8fdb\u884c\u60a3\u8005\u76d1\u6d4b\uff08\u81f3\u5c11\u81f3\u672b\u6b21\u7ed9\u836f\u540e<span>5<\/span>\u4e2a\u6708\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u5e94\u6682\u65f6\u505c\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\uff0c\u5e76\u5e94\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u3002\u5f53\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u6539\u5584\u81f3\u2264<span>1<\/span>\u7ea7\u65f6\uff0c\u9700\u81f3\u5c11\u4e00\u4e2a\u6708\u7684\u65f6\u95f4\u9010\u6b65\u51cf\u5c11\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7684\u7528\u91cf\u76f4\u81f3\u505c\u836f\u3002\u57fa\u4e8e\u6709\u9650\u7684\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff0c\u53d1\u751f\u7cd6\u76ae\u8d28\u6fc0\u7d20\u65e0\u6cd5\u63a7\u5236\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u65f6\u53ef\u4ee5\u8003\u8651\u4f7f\u7528\u5176\u4ed6\u5168\u8eab\u6027\u514d\u75ab\u6291\u5236\u5242\u3002\u5982\u679c\u4e0d\u826f\u53cd\u5e94\u4fdd\u6301\u5728\u2264<span>1<\/span>\u7ea7\uff0c\u4e14\u7cd6\u76ae\u8d28\u6fc0\u7d20\u5242\u91cf\u5df2\u964d\u81f3\u6bcf\u5929\u2264<span>10mg<\/span>\u6cfc\u5c3c\u677e\u6216\u7b49\u6548\u5242\u91cf\uff0c\u5219\u53ef\u5728\u6700\u540e\u4e00\u6b21\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ed9\u836f\u540e<span>12<\/span>\u5468\u5185\u91cd\u65b0\u5f00\u59cb\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u60a3\u8005\u63a5\u53d7\u514d\u75ab\u6291\u5236\u5242\u91cf\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u671f\u95f4\uff0c\u4e0d\u53ef\u91cd\u65b0\u4f7f\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">12.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u51fa\u73b0\u4efb\u4f55\u91cd\u5ea6\u3001\u590d\u53d1\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u4ee5\u53ca\u4efb\u4f55\u5371\u53ca\u751f\u547d\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5fc5\u987b\u6c38\u4e45\u505c\u6b62\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">13.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u662f\u4e00\u79cd\u4eba\u5355\u514b\u9686\u6297\u4f53\uff0c\u56e0\u5355\u514b\u9686\u6297\u4f53\u4e0d\u7ecf<span>CYP450<\/span>\u6216\u5176\u4ed6\u836f\u7269\u4ee3\u8c22\u9176\u4ee3\u8c22\uff0c\u56e0\u6b64\uff0c\u5408\u5e76\u4f7f\u7528\u7684\u836f\u7269\u5bf9\u8fd9\u4e9b\u9176\u7684\u6291\u5236\u6216\u8bf1\u5bfc\u4f5c\u7528\u9884\u671f\u4e0d\u4f1a\u5f71\u54cd\u5e15\u535a\u5229\u73e0\u5355\u6297\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u6027\u8d28\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">14.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7f8e\u56fd<span>FDA<\/span>\u3001\u6b27\u76df<span>EMA<\/span>\u548c\u65e5\u672c<span>PMDA<\/span>\u6279\u51c6\u5e15\u535a\u5229\u73e0\u5355\u6297\u7684\u9002\u5e94\u8bc1\u8fd8\u5305\u62ec\uff1a\u5728\u6392\u9664<span>EGFR<\/span>\u6216<span>ALK<\/span>\u9633\u6027\u57fa\u7840\u4e0a\uff0c\u7528\u4e8e<span>PD-L1<\/span>\u8868\u8fbe\u2265<span>1%<\/span>\u7684\u665a\u671f<span>NSCLC<\/span>\u4e8c\u7ebf\u5355\u836f\u6cbb\u7597\u3002\u7f8e\u56fd<span>FDA<\/span>\u8fd8\u6279\u51c6\u5e15\u535a\u5229\u73e0\u5355\u6297\u5355\u836f\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u548c\u513f\u7ae5\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027<span>MSI-H<\/span>\u6216\u9519\u914d\u4fee\u590d\u7f3a\u9677\u7684\u5b9e\u4f53\u7624\u4ee5\u53ca\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\u9ad8\uff08<span>TMB-H<\/span>\uff09\u7684\u65e0\u6cd5\u5207\u9664\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\uff08\u5305\u62ec\u5c0f\u7ec6\u80de\u80ba\u764c\uff09\u3002\u76ee\u524d\u56fd\u5185\u5c1a\u672a\u83b7\u6279\u8fd9\u4e9b\u9002\u5e94\u8bc1\uff0c\u53ef\u5728\u4e0e\u60a3\u8005\u5145\u5206\u6c9f\u901a\u7684\u60c5\u51b5\u4e0b\u3001\u6309\u7167<span>FDA<\/span>\u6279\u51c6\u7684\u7528\u6cd5\u6b63\u786e\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e00\u3001\u5ea6\u4f10\u5229\u5c24\u5355\u6297<span> Durvalumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>120mg<\/span>\uff08<span>2.4ml<\/span>\uff09<span>\/<\/span>\u74f6\u3001<span>500mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1<b>.<\/b><\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u9002\u7528\u4e8e\u5728\u63a5\u53d7\u94c2\u7c7b\u836f\u7269\u4e3a\u57fa\u7840\u7684\u5316\u7597\u540c\u6b65\u653e\u7597\u540e\u672a\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u4e0d\u53ef\u5207\u9664\u3001\u2162\u671f<span>NSCLC<\/span>\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u8054\u5408\u4f9d\u6258\u6cca\u82f7\u548c\u5361\u94c2\u6216\u987a\u94c2\uff0c\u4e00\u7ebf\u6cbb\u7597\u5e7f\u6cdb\u671f\u5c0f\u7ec6\u80de\u80ba\u764c\uff08<span>ES-SCLC<\/span>\uff09\u6210\u4eba\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u53ef\u5207\u9664\u7684\u2162\u671f<span>NSCLC<\/span>\uff1a\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u7684\u4f7f\u7528\u65b9\u6cd5\u662f<span>10mg\/kg<\/span>\uff0c\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\uff0c\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff0c\u6bcf\u6b21\u8f93\u6ce8\u9700\u8d85\u8fc7<span>60<\/span>\u5206\u949f\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u80fd\u8010\u53d7\u7684\u6bd2\u6027\u3002\u6700\u957f\u4f7f\u7528\u4e0d\u8d85\u8fc7<span>12<\/span>\u4e2a\u6708\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.ES-SCLC<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a<span>1500mg<\/span>\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u8054\u5408\u4f9d\u6258\u6cca\u82f7\u548c\u5361\u94c2\u6216\u987a\u94c2\uff0c\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c\u6301\u7eed<span>4<\/span>\u4e2a\u5468\u671f\uff0c\u7ee7\u4e4b\u4ee5<span>1500mg<\/span>\u6bcf<span>4<\/span>\u5468\u4e00\u6b21\u4f5c\u4e3a\u5355\u836f\u6cbb\u7597\uff0c\u76f4\u81f3\u53d1\u751f\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u80fd\u8010\u53d7\u7684\u6bd2\u6027\u3002\u4f53\u91cd\u5728<span>30kg<\/span>\u6216\u4ee5\u4e0b\u7684\u60a3\u8005\u5fc5\u987b\u63a5\u53d7\u57fa\u4e8e\u4f53\u91cd\u7684\u7ed9\u836f\uff0c\u5373\u5ea6\u4f10\u5229\u5c24\u5355\u6297<span>20mg\/kg<\/span>\u8054\u5408\u5316\u7597\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c\u6301\u7eed<span>4<\/span>\u4e2a\u5468\u671f\uff0c\u7ee7\u4e4b\u4ee5<span>20mg\/kg<\/span>\u6bcf<span>4<\/span>\u5468\u4e00\u6b21\u5355\u836f\u6cbb\u7597\uff0c\u76f4\u81f3\u4f53\u91cd\u589e\u52a0\u81f3\u5927\u4e8e<span>30kg<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><a name=\"_Hlk59364010\"><\/a><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u7684\u7c7b\u578b\u548c\u4e25\u91cd\u7a0b\u5ea6\uff0c\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\uff0c\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c1a\u672a\u786e\u7acb\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u5728<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u53ca\u9752\u5c11\u5e74\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u8001\u5e74\u60a3\u8005\uff08\u2265<span>65<\/span>\u5c81\uff09\u3001\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u3001\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u5747\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002\u5728\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u3001\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u4f7f\u7528\u7684\u5b89\u5168\u6027\u53ca\u6709\u6548\u6027\u5c1a\u672a\u5efa\u7acb\uff0c\u5982\u7ecf\u533b\u5e08\u8bc4\u4f30\u4f7f\u7528\u672c\u54c1\u9884\u671f\u83b7\u76ca\u5927\u4e8e\u98ce\u9669\uff0c\u9700\u5728\u533b\u5e08\u6307\u5bfc\u4e0b\u8c28\u614e\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e8c\u3001\u963f\u66ff\u5229\u73e0\u5355\u6297<span> Atezolizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>1200mg<\/span>\uff08<span>20ml<\/span>\uff09<span>\/<\/span>\u74f6 <span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u66ff\u5229\u73e0\u5355\u6297\u4e0e\u5361\u94c2\u548c\u4f9d\u6258\u6cca\u82f7\u8054\u5408\u7528\u4e8e<span>ES-SCLC<\/span>\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u66ff\u5229\u73e0\u5355\u6297\u7528\u4e8e\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u8bc4\u4f30\u4e3a\u2265<span>50%<\/span>\u80bf\u7624\u7ec6\u80de<span>PD-L1<\/span>\u67d3\u8272\u9633\u6027\uff08<span>TC<\/span>\u2265<span>50%<\/span>\uff09\u6216\u80bf\u7624\u6d78\u6da6<span>PD-L1<\/span>\u9633\u6027\u514d\u75ab\u7ec6\u80de\uff08<span>IC<\/span>\uff09\u8986\u76d6\u2265<span>10%<\/span>\u7684\u80bf\u7624\u9762\u79ef\uff08<span>IC<\/span>\u2265<span>10%<\/span>\uff09\u7684<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c<span>ALK<\/span>\u9634\u6027\u7684\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u4e00\u7ebf\u5355\u836f\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u66ff\u5229\u73e0\u5355\u6297\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u94c2\u7c7b\u5316\u7597\u7528\u4e8e<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c<span>ALK<\/span>\u9634\u6027\u7684\u8f6c\u79fb\u6027\u975e\u9cde\u72b6<span>NSCLC<\/span>\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u66ff\u5229\u73e0\u5355\u6297\u7684\u7528\u6cd5\u662f\u56fa\u5b9a\u5242\u91cf<span>1200mg<\/span>\uff0c\u901a\u8fc7\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\uff0c\u9996\u6b21\u7ed9\u836f\u81f3\u5c11\u6301\u7eed<span>60<\/span>\u5206\u949f\uff0c\u82e5\u9996\u6b21\u8f93\u6ce8\u60a3\u8005\u8010\u53d7\u6027\u826f\u597d\uff0c\u540e\u7eed\u53ef\u81f3\u5c11<span>30<\/span>\u5206\u949f\u3002\u7528\u4e8e<span>ES-SCLC<\/span>\u65f6\uff0c\u8bf1\u5bfc\u671f\u8054\u5408\u5361\u94c2\u548c\u4f9d\u6258\u6cca\u82f7\u65b9\u6848\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c\u6cbb\u7597<span>4<\/span>\u4e2a\u5468\u671f\u540e\u8fdb\u5165\u65e0\u5316\u7597\u7684\u7ef4\u6301\u671f\u3002\u7528\u4e8e<span>NSCLC<\/span>\u4e00\u7ebf\u5355\u836f\u6cbb\u7597\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\u3002\u7528\u4e8e<span>NSCLC<\/span>\u4e00\u7ebf\u8054\u5408\u5316\u7597\u65f6\uff0c\u8bf1\u5bfc\u671f\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u94c2\u7c7b\u65b9\u6848\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c\u6cbb\u7597<span>4<\/span>\u4e2a\u6216<span>6<\/span>\u4e2a\u6cbb\u7597\u5468\u671f\u540e\u8fdb\u5165\u963f\u66ff\u5229\u73e0\u5355\u6297\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u7684\u7ef4\u6301\u671f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u60a3\u8005\u53ef\u63a5\u53d7\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u76f4\u81f3\u65e0\u4e34\u5e8a\u83b7\u76ca\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u4f46\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\u3002\u5e94\u5bf9\u75be\u75c5\u8fdb\u5c55\u540e\u7ee7\u7eed\u4f7f\u7528\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u5f00\u5c55\u5bc6\u5207\u76d1\u6d4b\uff0c<span>4<\/span>\uff5e<span>8<\/span>\u5468\u5185\u91cd\u590d\u80bf\u7624\u7597\u6548\u8bc4\u4f30\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u6839\u636e\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u7684\u7c7b\u578b\u548c\u4e25\u91cd\u7a0b\u5ea6\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\uff0c\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u4f7f\u7528\u672c\u54c1\u4e4b\u524d\u5e94\u5c3d\u91cf\u907f\u514d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u836f\u7269\u53ef\u80fd\u4f1a\u5f71\u54cd\u672c\u54c1\u7684\u836f\u6548\u5b66\u6d3b\u6027\u53ca\u7597\u6548\u3002\u4f46\u5728\u672c\u54c1\u5f00\u59cb\u7ed9\u836f\u540e\uff0c\u53ef\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u3002\u5728\u60a3\u8005\u63a5\u53d7\u8fbe\u5230\u514d\u75ab\u6291\u5236\u5242\u91cf\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u671f\u95f4\uff0c\u4e0d\u5efa\u8bae\u91cd\u65b0\u4f7f\u7528\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c1a\u672a\u786e\u7acb\u963f\u66ff\u5229\u73e0\u5355\u6297\u5728<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u548c\u9752\u5c11\u5e74\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u8001\u5e74\u60a3\u8005\uff08\u2265<span>65<\/span>\u5c81\uff09\u3001\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u3001\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u5728\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u3001\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u4f7f\u7528\u7684\u5b89\u5168\u6027\u53ca\u6709\u6548\u6027\u5c1a\u672a\u5efa\u7acb\uff0c\u5982\u7ecf\u533b\u5e08\u8bc4\u4f30\u4f7f\u7528\u672c\u54c1\u9884\u671f\u83b7\u76ca\u5927\u4e8e\u98ce\u9669\uff0c\u9700\u5728\u533b\u5e08\u6307\u5bfc\u4e0b\u8c28\u614e\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7f8e\u56fd<span>FDA<\/span>\u6279\u51c6\u963f\u66ff\u5229\u73e0\u5355\u6297\u7684\u9002\u5e94\u8bc1\u8fd8\u5305\u62ec\uff1a\u963f\u66ff\u5229\u73e0\u5355\u6297\u4f5c\u4e3a<span>PD-L1 TC<\/span>\u2265<span>1% <\/span>\u2161<span>&#8211;<\/span>\u2162<span>A<\/span>\u671f<span>NSCLC<\/span>\u60a3\u8005\u63a5\u53d7\u624b\u672f\u548c\u542b\u94c2\u5316\u7597\u540e\u7684\u8f85\u52a9\u6cbb\u7597\uff1b\u8054\u5408\u767d\u86cb\u767d\u7d2b\u6749\u9187\u548c\u5361\u94c2\u7528\u4e8e<span>EGFR\/ALK<\/span>\u9634\u6027\u7684\u665a\u671f\u975e\u9cde\u72b6\u7ec6\u80de<span>NSCLC<\/span>\u4e00\u7ebf\u6cbb\u7597\uff1b\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u548c\u7d2b\u6749\u9187\u548c\u5361\u94c2\u7528\u4e8e<span>EGFR\/ALK<\/span>\u9634\u6027\u7684\u665a\u671f\u975e\u9cde\u72b6\u7ec6\u80de<span>NSCLC<\/span>\u4e00\u7ebf\u6cbb\u7597\uff1b\u963f\u66ff\u5229\u73e0\u5355\u6297\u5355\u836f\u7528\u4e8e\u665a\u671f<span>NSCLC<\/span>\u542b\u94c2\u5316\u7597\u8fdb\u5c55\u540e\u7684\u4e8c\u7ebf\u6cbb\u7597\uff1b\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u5168\u8eab\u7cfb\u7edf\u6027\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\uff1b\u4f5c\u4e3a\u4e0d\u9002\u5408\u542b\u94c2\u5316\u7597\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b\u4e0e\u5361\u6bd4\u66ff\u5c3c\u548c\u7ef4\u83ab\u975e\u5c3c\u8054\u5408\u7528\u4e8e\u6cbb\u7597<span>BRAF V600<\/span>\u7a81\u53d8\u9633\u6027\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u3002\u9664\u809d\u7ec6\u80de\u764c\u5916\uff0c\u8fd9\u4e9b\u9002\u5e94\u8bc1\u76ee\u524d\u56fd\u5185\u5c1a\u672a\u83b7\u6279\uff0c\u53ef\u5728\u4e0e\u60a3\u8005\u5145\u5206\u6c9f\u901a\u7684\u60c5\u51b5\u4e0b\u3001\u6309\u7167<span>FDA<\/span>\u6279\u51c6\u7684\u7528\u6cd5\u6b63\u786e\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e09\u3001\u5361\u745e\u5229\u73e0\u5355\u6297<span> Camrelizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7c89\u9488\u5242\uff1a<span>200mg\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5361\u745e\u5229\u73e0\u5355\u6297\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u5361\u94c2\u9002\u7528\u4e8e<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c<span>ALK<\/span>\u9634\u6027\u7684\u3001\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u7ec6\u80de<span>NSCLC<\/span>\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u8bca\u65ad\u4e3a<span>EGFR<\/span>\u7a81\u53d8\u9634\u6027\u548c<span>ALK<\/span>\u9634\u6027\u7684\u975e\u9cde\u72b6\u7ec6\u80de<span>NSCLC<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u8be5\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\u8bc4\u4f30\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u53cd\u5e94\u53ca\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u91c7\u7528\u9759\u8109\u8f93\u6ce8\u7684\u65b9\u5f0f\u7ed9\u836f\uff0c\u9759\u8109\u8f93\u6ce8\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>200mg<\/span>\uff0c\u6bcf\u6b21\u6301\u7eed<span>30<\/span>\uff5e<span>60<\/span>\u5206\u949f\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u5f53\u5361\u745e\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u7ed9\u836f\u65f6\uff0c\u5e94\u9996\u5148\u7ed9\u4e88\u5361\u745e\u5229\u73e0\u5355\u6297\u9759\u8109\u6ef4\u6ce8\uff0c\u95f4\u9694\u81f3\u5c11<span>30<\/span>\u5206\u949f\u540e\u518d\u7ed9\u4e88\u5316\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u51fa\u73b0\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\u3002\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u672c\u54c1\u5c1a\u65e0\u9488\u5bf9\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u5e08\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u672c\u54c1\u5c1a\u65e0\u9488\u5bf9\u4e2d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u4e2d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002\u8f7b\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u5e08\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5c1a\u65e0\u5728<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u53ca\u9752\u5c11\u5e74\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5728\u2265<span>65<\/span>\u5c81\u7684\u8001\u5e74\u60a3\u8005\u4e2d\u5e94\u7528\u6570\u636e\u6709\u9650\uff0c\u5efa\u8bae\u5728\u533b\u5e08\u7684\u6307\u5bfc\u4e0b\u614e\u7528\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u5efa\u8bae\u5728\u598a\u5a20\u671f\u95f4\u4f7f\u7528\u672c\u54c1\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56e0\u53ef\u80fd\u5e72\u6270\u672c\u54c1\u836f\u6548\u5b66\u6d3b\u6027\uff0c\u5e94\u907f\u514d\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002\u4f46\u662f\u5982\u679c\u4e3a\u4e86\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u540e\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">12.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5361\u745e\u5229\u73e0\u5355\u6297\u662f\u4e00\u79cd\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\uff0c\u5c1a\u672a\u8fdb\u884c\u4e0e\u5176\u4ed6\u836f\u7269\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u76f8\u4e92\u4f5c\u7528\u7814\u7a76\u3002\u56e0\u5355\u514b\u9686\u6297\u4f53\u4e0d\u7ecf<span>CYP450<\/span>\u9176\u6216\u5176\u4ed6\u836f\u7269\u4ee3\u8c22\u9176\u4ee3\u8c22\uff0c\u56e0\u6b64\u5408\u5e76\u4f7f\u7528\u7684\u836f\u7269\u5bf9\u8fd9\u4e9b\u9176\u7684\u6291\u5236\u6216\u8bf1\u5bfc\u4f5c\u7528\u9884\u671f\u4e0d\u4f1a\u5f71\u54cd\u5361\u745e\u5229\u73e0\u5355\u6297\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u6027\u8d28\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">13.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u7684\u5904\u7406\uff1a\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u5171<span>1023<\/span>\u4f8b\uff08<span>77.4%<\/span>\uff09\u53d1\u751f\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\uff0c\u5176\u4e2d<span>1<\/span>\u7ea7\u4e3a<span>827<\/span>\u4f8b\uff08<span>62.6%<\/span>\uff09\uff0c<span>2<\/span>\u7ea7\u4e3a<span>182<\/span>\u4f8b\uff08<span>13.8%<\/span>\uff09\uff0c<span>3<\/span>\u7ea7\u4e3a<span>14<\/span>\u4f8b\uff08<span>1.1%<\/span>\uff09\u3002\u6240\u6709\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u5747\u53d1\u751f\u5728\u4f53\u8868\uff0c\u5176\u4e2d<span>3.9%<\/span>\uff08<span>52\/1321<\/span>\uff09\u4f34\u53d1\u4e8e\u53e3\u8154\u3001<span>1.1%<\/span>\uff08<span>14\/1321<\/span>\uff09\u4f34\u53d1\u4e8e\u9f3b\u8154\u9ecf\u819c\u3001<span>0.5%<\/span>\uff08<span>7\/1321<\/span>\uff09\u4f34\u53d1\u4e8e\u773c\u7751\u3001<span>0.5%<\/span>\uff08<span>6\/1321<\/span>\uff09\u4f34\u53d1\u4e8e\u773c\u90e8\uff1b<span>16.5%<\/span>\u53d1\u751f\u5408\u5e76\u51fa\u8840\uff0c<span>1.1%<\/span>\u53d1\u751f\u5408\u5e76\u611f\u67d3\u3002\u81f3\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u53d1\u751f\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a<span>0.9<\/span>\u4e2a\u6708\uff08\u8303\u56f4\uff1a<span>0.0<\/span>\uff5e<span>8.1<\/span>\u4e2a\u6708\uff09\uff0c\u6301\u7eed\u7684\u4e2d\u4f4d\u65f6\u95f4\u662f<span>6.3<\/span>\u4e2a\u6708\uff08\u8303\u56f4\uff1a<span>0.2<\/span>\uff5e<span>32.8<\/span>\u4e2a\u6708\uff09\u3002\u53d1\u751f\u4e8e\u76ae\u80a4\u7684\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\uff0c\u521d\u59cb\u591a\u8868\u73b0\u4e3a\u4f53\u8868\u9c9c\u7ea2\u8272\u70b9\u72b6\u7269\uff0c\u76f4\u5f84\u2264<span>2mm<\/span>\uff0c\u968f\u7740\u7528\u836f\u6b21\u6570\u589e\u52a0\uff0c\u75c5\u53d8\u8303\u56f4\u53ef\u9010\u6e10\u589e\u5927\uff0c\u591a\u4e3a\u7ed3\u8282\u72b6\uff0c\u4e5f\u6709\u6591\u7247\u72b6\uff0c\u989c\u8272\u9c9c\u7ea2\u6216\u6697\u7ea2\uff0c\u9700\u89c2\u5bdf\u4e34\u5e8a\u75c7\u72b6\u548c\u4f53\u5f81\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5f53\u60a3\u8005\u51fa\u73b0\u8be5\u4e0d\u826f\u53cd\u5e94\u65f6\uff0c\u5e94\u907f\u514d\u6293\u6320\u6216\u6469\u64e6\uff0c\u6613\u6469\u64e6\u90e8\u4f4d\u53ef\u7528\u7eb1\u5e03\u4fdd\u62a4\u4ee5\u907f\u514d\u51fa\u8840\uff0c\u540c\u65f6\u5e94\u8054\u7cfb\u4e3b\u7ba1\u533b\u5e08\uff0c\u83b7\u5f97\u6070\u5f53\u7684\u5904\u7406\u5efa\u8bae\u3002\u7834\u6e83\u51fa\u8840\u8005\u53ef\u91c7\u7528\u5c40\u90e8\u538b\u8feb\u6b62\u8840\uff0c\u53cd\u590d\u51fa\u73b0\u8005\u53ef\u5728\u6b62\u8840\u540e\u4e8e\u76ae\u80a4\u79d1\u5c31\u8bca\uff0c\u6216\u91c7\u53d6\u5982\u6fc0\u5149\u6216\u624b\u672f\u5207\u9664\u7b49\u5c40\u90e8\u6cbb\u7597\uff1b\u5e76\u53d1\u611f\u67d3\u8005\u5e94\u7ed9\u4e88\u6297\u611f\u67d3\u6cbb\u7597\u3002\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u53ef\u80fd\u5728\u76ae\u80a4\u4ee5\u5916\u7684\u5176\u4ed6\u7ec4\u7ec7\u53d1\u751f\uff08\u5305\u62ec\u7751\u7ed3\u819c\u3001\u5185\u5916\u7726\u3001\u53e3\u8154\u9ecf\u819c\u3001\u54bd\u5589\u7b49\u6d88\u5316\u9053\u9ecf\u819c\u6216\u5176\u4ed6\u810f\u5668\uff09\uff0c\u5fc5\u8981\u65f6\u8fdb\u884c\u76f8\u5e94\u7684\u533b\u5b66\u68c0\u67e5\uff0c\u5982\u5927\u4fbf\u6f5c\u8840\u3001\u5185\u7aa5\u955c\u53ca\u5f71\u50cf\u5b66\u68c0\u67e5\uff08\u5177\u4f53\u76f8\u5173\u5185\u5bb9\u8be6\u89c1\u300a\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u4fe1\u606f\u6536\u96c6\u53ca\u98ce\u9669\u7ba1\u7406\u8ba1\u5212\u300b\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u56db\u3001\u66ff\u96f7\u5229\u73e0\u5355\u6297<span> Tislelizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u7d2b\u6749\u9187\u548c\u5361\u94c2\u6216\u767d\u86cb\u767d\u7d2b\u6749\u9187\u548c\u5361\u94c2\u7528\u4e8e\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u9cde\u72b6<span>NSCLC<\/span>\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u94c2\u7c7b\u5316\u7597\u7528\u4e8e<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c<span>ALK<\/span>\u9634\u6027\u3001\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6<span>NSCLC<\/span>\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u91c7\u7528\u9759\u8109\u8f93\u6ce8\u7684\u65b9\u5f0f\u7ed9\u836f\uff0c\u63a8\u8350\u5242\u91cf\u4e3a<span>200mg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\u3002\u7528\u836f\u76f4\u5230\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0e\u5316\u7597\u8054\u7528\u65f6\uff0c\u82e5\u4e3a\u540c\u65e5\u7ed9\u836f\u5219\u5148\u8f93\u6ce8\u66ff\u96f7\u5229\u73e0\u5355\u6297\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u6709\u521d\u6b65\u7684\u75be\u75c5\u8fdb\u5c55\u8868\u73b0\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\uff0c\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\uff0c\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\uff0c\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e94\u3001\u4fe1\u8fea\u5229\u5355\u6297<span> Sintilimab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u94c2\u7c7b\u5316\u7597\uff0c\u7528\u4e8e\u672a\u7ecf\u7cfb\u7edf\u6cbb\u7597\u7684<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c<span>ALK<\/span>\u9634\u6027\u7684\u665a\u671f\u6216\u590d\u53d1\u6027\u975e\u9cde\u72b6\u7ec6\u80de<span>NSCLC<\/span>\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u5409\u897f\u4ed6\u6ee8\u548c\u94c2\u7c7b\u5316\u7597\uff0c\u7528\u4e8e\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u665a\u671f\u6216\u590d\u53d1\u6027\u9cde\u72b6\u7ec6\u80de<span>NSCLC<\/span>\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u91c7\u7528\u9759\u8109\u8f93\u6ce8\u7684\u65b9\u5f0f\u7ed9\u836f\uff0c\u9759\u8109\u8f93\u6ce8\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>200mg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u4ea7\u751f\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u9759\u8109\u8f93\u6ce8\u65f6\u95f4\u5e94\u5728<span>30<\/span>\uff5e<span>60<\/span>\u5206\u949f\u5185\u3002\u4e0d\u5f97\u901a\u8fc7\u9759\u8109\u63a8\u6ce8\u6216\u5355\u6b21\u5feb\u901f\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u5f71\u50cf\u5b66\u521d\u6b65\u8bc1\u636e\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\u3002\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002\u76ee\u524d\u5c1a\u65e0\u9488\u5bf9\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u6216\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u72ec\u7acb\u7814\u7a76\u6570\u636e\u3002\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u6216\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c1a\u65e0\u5728<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u53ca\u9752\u5c11\u5e74\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e\u3002\u5728\u8001\u5e74\uff08\u2265<span>65<\/span>\u5c81\uff09\u4e0e\u5e74\u8f7b\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u672a\u663e\u793a\u663e\u8457\u5dee\u5f02\u3002\u5efa\u8bae\u5728\u533b\u751f\u7684\u6307\u5bfc\u4e0b\u614e\u7528\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u5efa\u8bae\u5728\u598a\u5a20\u671f\u95f4\u4f7f\u7528\u672c\u54c1\u6cbb\u7597\u3002\u5efa\u8bae\u54fa\u4e73\u671f\u5987\u5973\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u53ca\u672b\u6b21\u7ed9\u836f\u540e\u81f3\u5c11<span>5<\/span>\u4e2a\u6708\u5185\u505c\u6b62\u54fa\u4e73\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u907f\u514d\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\uff0c\u4f46\u662f\u5982\u679c\u4e3a\u4e86\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u540e\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u516d\u3001\u4f0a\u5339\u6728\u5355\u6297 <span>Ipilimumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>50mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u8054\u5408\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u7528\u4e8e\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u3001\u521d\u6cbb\u7684\u975e\u4e0a\u76ae\u6837\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u6210\u4eba\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>1mg\/kg<\/span>\uff0c\u6bcf<span>6<\/span>\u5468\u4e00\u6b21\uff0c\u9759\u8109\u8f93\u6ce8<span>30<\/span>\u5206\u949f\uff0c\u8054\u5408<span>360mg<\/span>\u7eb3\u6b66\u5229\u5c24\u5355\u6297\uff0c\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c\u6216\u8054\u5408<span>3mg\/kg<\/span>\u7eb3\u6b66\u5229\u5c24\u5355\u6297\uff0c\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff0c\u9759\u8109\u8f93\u6ce8<span>30<\/span>\u5206\u949f\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4ea7\u751f\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\uff0c\u6216\u81f3<span>24<\/span>\u4e2a\u6708\u7684\u60a3\u8005\u6ca1\u6709\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5df2\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5bf9\u4e8e\u4e34\u5e8a\u7a33\u5b9a\u4e14\u6709\u75be\u75c5\u8fdb\u5c55\u521d\u6b65\u8bc1\u636e\u7684\u60a3\u8005\uff0c\u5efa\u8bae\u7ee7\u7eed\u4f7f\u7528\u672c\u54c1\u8054\u5408\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u5728\u57fa\u7ebf\u65f6\u548c\u6bcf\u5242\u672c\u54c1\u7ed9\u836f\u4e4b\u524d\u8bc4\u4f30\u809d\u529f\u80fd\u548c\u7532\u72b6\u817a\u529f\u80fd\u3002\u6b64\u5916\uff0c\u5728\u7528\u672c\u54c1\u6cbb\u7597\u671f\u95f4\uff0c\u5fc5\u987b\u8bc4\u4f30\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u7684\u4efb\u4f55\u4f53\u5f81\u6216\u75c7\u72b6\uff08\u5305\u62ec\u8179\u6cfb\u548c\u7ed3\u80a0\u708e\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u53ef\u4e0d\u7ecf\u7a00\u91ca\u7528\u4e8e\u9759\u8109\u8f93\u6ce8\uff0c\u6216\u8005\u91c7\u7528\u6ce8\u5c04\u7528\u6c2f\u5316\u94a0\u6eb6\u6db2\uff08<span>9mg\/ml<\/span>\uff0c<span>0.9%<\/span>\uff09\u6216\u6ce8\u5c04\u7528\u8461\u8404\u7cd6\u6eb6\u6db2\uff08<span>50mg\/ml<\/span>\uff0c<span>5%<\/span>\uff09\u7a00\u91ca\u6d53\u5ea6\u81f3<span>1<\/span>\uff5e<span>4mg\/ml<\/span>\u540e\u8f93\u6ce8\u4f7f\u7528\u3002\u672c\u54c1\u4e0d\u5f97\u4ee5\u9759\u8109\u63a8\u6ce8\u6216\u5355\u6b21\u5feb\u901f\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5f53\u4e0e\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u7528\u65f6\uff0c\u5e94\u5148\u8f93\u6ce8\u7eb3\u6b66\u5229\u5c24\u5355\u6297\uff0c\u4e4b\u540e\u540c\u4e00\u5929\u8f93\u6ce8\u672c\u54c1\u3002\u6bcf\u6b21\u8f93\u6ce8\u9700\u4f7f\u7528\u5355\u72ec\u7684\u8f93\u6db2\u888b\u548c\u8fc7\u6ee4\u5668\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u5339\u6728\u5355\u6297\u8054\u5408\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u662f\u76ae\u75b9\u3001\u75b2\u4e4f\u3001\u8179\u6cfb\u3001\u7619\u75d2\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u548c\u6076\u5fc3\u3002\u5927\u591a\u6570\u4e0d\u826f\u53cd\u5e94\u4e3a\u8f7b\u4e2d\u5ea6\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51fa\u73b0<span>4<\/span>\u7ea7\u6216\u590d\u53d1\u6027<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u6216\u8005\u867d\u7136\u8fdb\u884c\u6cbb\u7597\u8c03\u6574\u4f46\u4ecd\u6301\u7eed\u5b58\u5728\u7684<span>2<\/span>\u7ea7\u6216<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\u65f6\uff0c\u5e94\u6c38\u4e45\u6027\u505c\u6b62\u672c\u54c1\u4e0e\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u6cbb\u7597<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5f53\u672c\u54c1\u4e0e\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u7ed9\u836f\u65f6\uff0c\u82e5\u6682\u505c\u4efb\u4e00\u836f\u7269\uff0c\u5219\u5e94\u540c\u65f6\u6682\u505c\u53e6\u4e00\u836f\u7269\u3002\u82e5\u5728\u6682\u505c\u540e\u91cd\u65b0\u5f00\u59cb\u7ed9\u836f\uff0c\u5219\u5e94\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u8bc4\u4f30\u60c5\u51b5\u91cd\u65b0\u5f00\u59cb\u8054\u5408\u6cbb\u7597\u6216\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u5355\u836f\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7f8e\u56fd<span>FDA<\/span>\u548c\u6b27\u76df<span>EMA<\/span>\u6279\u51c6\u4f0a\u5339\u6728\u5355\u6297\u8054\u5408\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u665a\u671f\u548c\u8f6c\u79fb\u6027<span>NSCLC<\/span>\uff0c\u8be6\u89c1\u201c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u201d\u5408\u7406\u7528\u836f\u8981\u70b9\u7b2c<span>18<\/span>\u6761\u3002<span><\/span><\/span>\n<\/p>\n<p><b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><br \/>\n<\/span><\/b> <\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6d88\u5316\u7cfb\u7edf\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e00\u3001<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7d22\u62c9\u975e\u5c3c<span> Sorafenib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">200mg<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u65e0\u6cd5\u624b\u672f\u6216\u8fdc\u5904\u8f6c\u79fb\u7684\u809d\u7ec6\u80de\u764c\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u6709\u8179\u6cfb\u3001\u4e4f\u529b\u3001\u8131\u53d1\u3001\u611f\u67d3\u3001\u624b\u8db3\u76ae\u80a4\u53cd\u5e94\u3001\u76ae\u75b9\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u670d\u7528\u5242\u91cf\u4e3a<span>0.4g<\/span><\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\/<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b21<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u7a7a\u8179\u6216\u4f34\u4f4e\u8102\u3001\u4e2d\u8102\u996e\u98df\u670d\u7528\uff0c\u5fc5\u987b\u6574\u7247\u541e\u670d\uff0c\u5982\u679c\u6f0f\u670d\u6216\u5455\u5410\u540c\u4e00\u5929\u5185\u4e0d\u5f97\u8865\u670d\u3002\u5bf9\u7591\u4f3c\u4e0d\u826f\u53cd\u5e94\u7684\u5904\u7406\u5305\u62ec\u6682\u505c\u6216\u51cf\u5c11\u7528\u91cf\uff0c\u5982\u9700\u51cf\u5c11\u5242\u91cf\uff0c\u7d22\u62c9\u975e\u5c3c\u7684\u5242\u91cf\u51cf\u4e3a\u6bcf\u5929\u4e00\u6b21\uff0c<span>0.4g<\/span><\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\/<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b21<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u53e3\u670d\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0e\u901a\u8fc7<span>UGT1A1<\/span>\u9014\u5f84\u4ee3\u8c22<span>\/<\/span>\u6e05\u9664\u7684\u836f\u7269\uff08\u5982\u4f0a\u7acb\u66ff\u5eb7\u3001\u591a\u897f\u4ed6\u8d5b\uff09\u8054\u5408\u5e94\u7528\u65f6\u9700\u8c28\u614e\u3002\u4e0e\u534e\u6cd5\u6797\u5408\u7528\u65f6\u5e94\u5b9a\u671f\u68c0\u6d4b<span>INR<\/span>\u503c\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u7f3a\u4e4f\u5728\u665a\u671f\u809d\u7ec6\u80de\u764c\u60a3\u8005\u4e2d\u7d22\u62c9\u975e\u5c3c\u4e0e\u4ecb\u5165\u6cbb\u7597\u5982\u809d\u52a8\u8109\u6813\u585e\u5316\u7597\uff08<span>TACE<\/span>\uff09\u6bd4\u8f83\u7684\u968f\u673a\u5bf9\u7167\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff0c\u56e0\u6b64\u5c1a\u4e0d\u80fd\u660e\u786e\u672c\u54c1\u76f8\u5bf9\u4ecb\u5165\u6cbb\u7597\u7684\u4f18\u52a3\uff0c\u4e5f\u4e0d\u80fd\u660e\u786e\u5bf9\u65e2\u5f80\u63a5\u53d7\u8fc7\u4ecb\u5165\u6cbb\u7597\u540e\u60a3\u8005\u4f7f\u7528\u7d22\u62c9\u975e\u5c3c\u662f\u5426\u6709\u76ca\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.TACTICS<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7814\u7a76\uff08<span>NCT01217034<\/span>\uff09\u8bc1\u5b9e\u9996\u6b21<span>TACE<\/span>\u8054\u5408\u7d22\u62c9\u975e\u5c3c\u8f83\u7d22\u62c9\u975e\u5c3c\u7ec4\u83b7\u76ca\u66f4\u4f73\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u745e\u6208\u975e\u5c3c<span> Regorafenib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>40mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u63a5\u53d7\u8fc7\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u7684\u809d\u7ec6\u80de\u764c\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u63a5\u53d7\u8fc7\u4f0a\u9a6c\u66ff\u5c3c\u53ca\u8212\u5c3c\u66ff\u5c3c\u6cbb\u7597\u7684\u5c40\u90e8\u665a\u671f\u7684\u3001\u65e0\u6cd5\u624b\u672f\u5207\u9664\u7684\u6216\u8f6c\u79fb\u6027\u80c3\u80a0\u95f4\u8d28\u7624\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u63a5\u53d7\u8fc7\u6c1f\u5c3f\u5627\u5576\u3001\u5965\u6c99\u5229\u94c2\u548c\u4f0a\u7acb\u66ff\u5eb7\u4e3a\u57fa\u7840\u7684\u5316\u7597\uff0c\u4ee5\u53ca\u65e2\u5f80\u63a5\u53d7\u8fc7\u6216\u4e0d\u9002\u5408\u63a5\u53d7\u6297<span>VEGF<\/span>\u6cbb\u7597\u3001\u6297<span>EGFR<\/span>\u6cbb\u7597\uff08<span>RAS<\/span>\u91ce\u751f\u578b\uff09\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u65e0\u9700\u8fdb\u884c\u57fa\u56e0\u68c0\u6d4b\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u836f\u54c1\u8bf4\u660e\u4e66\u63a8\u8350\u5242\u91cf\u4e3a<span>160mg<\/span>\u53e3\u670d\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u5efa\u8bae\u4e0e\u98df\u7269\u540c\u670d\uff0c\u7528\u836f<span>3<\/span>\u5468\u505c\u836f<span>1<\/span>\u5468\u3002\u57fa\u4e8e\u4e2a\u4eba\u7684\u5b89\u5168\u53ca\u8010\u53d7\u6027\u8003\u8651\uff0c\u53ef\u80fd\u9700\u8981\u4e2d\u65ad\u6216\u964d\u4f4e\u5242\u91cf\uff0c\u4e5f\u53ef\u4ee5\u8003\u8651\u91c7\u7528<span>80<\/span>\uff5e<span>120mg<\/span>\u8d77\u59cb\u5242\u91cf\u9010\u6e10\u9012\u589e\u3002\u5fc5\u987b\u6574\u7247\u541e\u670d\uff0c\u5982\u679c\u6f0f\u670d\u6216\u5455\u5410\u540c\u4e00\u5929\u5185\u4e0d\u5f97\u8865\u670d\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e9a\u6d32\u4eba\u7fa4\u6700\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u4e3a\u624b\u8db3\u76ae\u80a4\u53cd\u5e94\u3001\u809d\u529f\u80fd\u5f02\u5e38\uff08\u9ad8\u80c6\u7ea2\u7d20\u8840\u75c7\u3001<span>ALT<\/span>\u5347\u9ad8\u3001<span>AST<\/span>\u5347\u9ad8\uff09\u548c\u9ad8\u8840\u538b\uff0c\u540c\u65f6\uff0c\u8fd8\u8981\u6ce8\u610f\u75bc\u75db\u3001\u4e4f\u529b\u3001\u8179\u6cfb\u3001\u98df\u6b32\u4e0b\u964d\u53ca\u8fdb\u98df\u51cf\u5c11\u7b49\u4e0d\u826f\u53cd\u5e94\uff1b\u6700\u4e25\u91cd\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u3001\u51fa\u8840\u3001\u80c3\u80a0\u9053\u7a7f\u5b54\u53ca\u611f\u67d3\uff1b\u6709\u8840\u6813\u3001\u6813\u585e\u75c5\u53f2\u8005\u5e94\u8c28\u614e\u4f7f\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u745e\u6208\u975e\u5c3c\u4efb\u4e00\u6d3b\u6027\u7269\u8d28\u6216\u8f85\u6599\u6709\u8d85\u654f\u53cd\u5e94\u7684\u60a3\u8005\u7981\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u8054\u7528<span>CYP3A4<\/span>\u5f3a\u6548\u6291\u5236\u5242\u548c\u8bf1\u5bfc\u5242\uff0c\u8054\u7528\u4f0a\u7acb\u66ff\u5eb7\u53ef\u80fd\u589e\u52a0<span>UGT1A1<\/span>\u548c<span>UGT1A9<\/span>\u5e95\u7269\u7684\u5168\u8eab\u66b4\u9732\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e09\u3001\u4ed1\u4f10\u66ff\u5c3c<span> Lenvatinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>4mg<\/span>\u3001<span>10mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u5168\u8eab\u7cfb\u7edf\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u6709\u9ad8\u8840\u538b\u3001\u75b2\u4e4f\u3001\u8179\u6cfb\u3001\u98df\u6b32\u4e0b\u964d\u3001\u4f53\u91cd\u964d\u4f4e\u3001\u5173\u8282\u75db<span>\/<\/span>\u808c\u75db\u3001\u8179\u75db\u3001\u638c\u8dd6\u7ea2\u80bf\u7efc\u5408\u5f81\u3001\u86cb\u767d\u5c3f\u3001\u51fa\u8840\u4e8b\u4ef6\u3001\u53d1\u97f3\u56f0\u96be\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u75c7\u3001\u6076\u5fc3\uff0c\u4e25\u91cd\u7684\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u809d\u8870\u7aed\u3001\u8111\u51fa\u8840\u3001\u547c\u5438\u8870\u7aed\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e0e\u7532\u72b6\u817a\u764c\u548c\u80be\u764c\u4e0d\u540c\uff0c\u4ed1\u4f10\u66ff\u5c3c\u5728\u809d\u764c\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u5728\u4e34\u5e8a\u4e0a\u53d7\u5230\u4f53\u91cd\u7684\u663e\u8457\u5f71\u54cd\uff1a\u5bf9\u4e8e\u4f53\u91cd\uff1c<span>60kg<\/span>\u7684\u60a3\u8005\uff0c\u63a8\u8350\u65e5\u5242\u91cf\u4e3a<span>8mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff1b\u5bf9\u4e8e\u4f53\u91cd\uff1e<span>60kg<\/span>\u7684\u60a3\u8005\uff0c\u63a8\u8350\u65e5\u5242\u91cf\u4e3a<span>12mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4ed1\u4f10\u66ff\u5c3c\u5e94\u5728\u6bcf\u5929\u56fa\u5b9a\u65f6\u95f4\u670d\u7528\uff0c\u7a7a\u8179\u6216\u4e0e\u98df\u7269\u540c\u670d\u5747\u53ef\u3002\u5982\u679c\u60a3\u8005\u9057\u6f0f\u4e00\u6b21\u7528\u836f\u4e14\u65e0\u6cd5\u5728<span>12<\/span>\u5c0f\u65f6\u5185\u670d\u7528\uff0c\u65e0\u9700\u8865\u670d\uff0c\u5e94\u6309\u5e38\u89c4\u7528\u836f\u65f6\u95f4\u8fdb\u884c\u4e0b\u4e00\u6b21\u670d\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u56db\u3001\u591a\u7eb3\u975e\u5c3c<span>Donafenib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>0.1g<\/span><\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u5168\u8eab\u7cfb\u7edf\u6027\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a <span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u6709\u624b\u8db3\u76ae\u80a4\u53cd\u5e94\u3001\u8179\u6cfb\u3001\u8840\u5c0f\u677f\u8ba1\u6570\u51cf\u5c11\u3001\u9ad8\u8840\u538b\u3001\u5929\u95e8\u51ac\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\u5347\u9ad8\u3001\u8131\u53d1\u3001\u76ae\u75b9\u548c\u86cb\u767d\u5c3f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u6b21<span>0.2g<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u7a7a\u8179\u53e3\u670d\uff0c\u4ee5\u6e29\u5f00\u6c34\u541e\u670d\u3002\u5efa\u8bae\u6bcf\u5929\u540c\u4e00\u65f6\u6bb5\u670d\u836f\uff0c\u5982\u679c\u6f0f\u670d\u836f\u7269\uff0c\u65e0\u9700\u8865\u670d\uff0c\u5e94\u6309\u5e38\u89c4\u7528\u836f\u65f6\u95f4\u8fdb\u884c\u4e0b\u4e00\u6b21\u670d\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u4f53\u5916\u7814\u7a76\u63d0\u793a\uff0c\u591a\u7eb3\u975e\u5c3c\u4e3b\u8981\u901a\u8fc7<span>CYP3A4<\/span>\u548c<span>UGTIA9<\/span>\u4ee3\u8c22\uff0c\u6b64\u5916<span>CYP1B1<\/span>\u3001<span>CYP2C8<\/span>\u3001<span>CYP2C9<\/span>\u3001<span>CYP2C19<\/span>\u3001<span>CYP2D6<\/span>\u548c<span>CYP3A5<\/span>\u4e5f\u90e8\u5206\u53c2\u4e0e\u591a\u7eb3\u975e\u5c3c\u7684\u4ee3\u8c22\u3002\u8054\u7528\u76f8\u5173\u4ee3\u8c22\u9176\u7684\u6291\u5236\u5242\u6216\u8bf1\u5bfc\u5242\u65f6\u5e94\u5f53\u8c28\u614e\u3002<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e94\u3001\u963f\u66ff\u5229\u73e0\u5355\u6297<span> Atezolizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>1200mg<\/span>\uff08<span>20ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u66ff\u5229\u73e0\u5355\u6297\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u5168\u8eab\u7cfb\u7edf\u6027\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u66ff\u5229\u73e0\u5355\u6297\u4e0e\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408\u7528\u836f\u57fa\u4e8e<span>IMbrave150<\/span>\u7814\u7a76\uff1a\u9996\u5148\u9759\u8109\u8f93\u6ce8\u963f\u66ff\u5229\u73e0\u5355\u6297\uff0c\u63a8\u8350\u5242\u91cf\u4e3a<span>1200mg<\/span>\uff0c\u7ee7\u4e4b\u4ee5\u9759\u8109\u8f93\u6ce8\u8d1d\u4f10\u73e0\u5355\u6297<span>15mg\/kg<\/span>\u3002\u8be5\u65b9\u6848\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\u3002\u9996\u6b21\u7ed9\u836f\u81f3\u5c11\u6301\u7eed<span>60<\/span>\u5206\u949f\uff0c\u540e\u7eed\u53ef\u81f3\u5c11<span>30<\/span>\u5206\u949f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u60a3\u8005\u53ef\u63a5\u53d7\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u76f4\u81f3\u65e0\u4e34\u5e8a\u83b7\u76ca\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u4f46\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\u3002\u5e94\u5bf9\u75be\u75c5\u8fdb\u5c55\u540e\u7ee7\u7eed\u4f7f\u7528\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u5f00\u5c55\u5bc6\u5207\u76d1\u6d4b\uff0c<span>4<\/span>\uff5e<span>8<\/span>\u5468\u5185\u91cd\u590d\u80bf\u7624\u7597\u6548\u8bc4\u4f30\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u6cbb\u7597\u524d\u8fdb\u884c\u5305\u62ec\u7532\u72b6\u817a\u529f\u80fd\u3001\u5fc3\u808c\u9176\u7b49\u7684\u57fa\u7ebf\u68c0\u6d4b\uff0c\u5728\u6cbb\u7597\u4e2d\u5b9a\u671f\u968f\u8bbf\u7528\u4e8e\u65e9\u671f\u53d1\u73b0\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u540c\u65f6\u9700\u6ce8\u610f\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u4e5f\u53ef\u80fd\u51fa\u73b0\u4e8e\u6cbb\u7597\u7ed3\u675f\u540e\u3002\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u6839\u636e\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u7684\u7c7b\u578b\u548c\u4e25\u91cd\u7a0b\u5ea6\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\uff0c\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002\u4e25\u91cd\u8005\u6216\u8bca\u65ad\u5b58\u7591\u8005\u53ef\u7531\u6d88\u5316\u79d1\u3001\u98ce\u6e7f\u79d1\u3001\u76ae\u80a4\u79d1\u3001\u547c\u5438\u79d1\u3001\u80bf\u7624\u79d1\u7b49\u7ec4\u6210\u7684\u514d\u75ab\u4e0d\u826f\u53cd\u5e94\u591a\u5b66\u79d1\u7efc\u5408\u6cbb\u7597\uff08<span>MDT<\/span>\uff09\u8fdb\u884c\u4f1a\u8bca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u4f7f\u7528\u672c\u54c1\u4e4b\u524d\u5e94\u5c3d\u91cf\u907f\u514d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u836f\u7269\u53ef\u80fd\u4f1a\u5f71\u54cd\u672c\u54c1\u7684\u836f\u6548\u5b66\u6d3b\u6027\u53ca\u7597\u6548\u3002\u4f46\u5728\u672c\u54c1\u5f00\u59cb\u7ed9\u836f\u540e\uff0c\u53ef\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u3002\u5728\u60a3\u8005\u63a5\u53d7\u514d\u75ab\u6291\u5236\u5242\u91cf\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u671f\u95f4\uff0c\u4e0d\u5efa\u8bae\u91cd\u65b0\u4f7f\u7528\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c1a\u672a\u786e\u7acb\u963f\u66ff\u5229\u73e0\u5355\u6297\u5728<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u548c\u9752\u5c11\u5e74\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u8001\u5e74\u60a3\u8005\uff08\u2265<span>65<\/span>\u5c81\uff09\u3001\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u3001\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u5728\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u3001\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u4f7f\u7528\u7684\u5b89\u5168\u6027\u53ca\u6709\u6548\u6027\u5c1a\u672a\u5efa\u7acb\uff0c\u5982\u7ecf\u533b\u5e08\u8bc4\u4f30\u4f7f\u7528\u672c\u54c1\u9884\u671f\u83b7\u76ca\u5927\u4e8e\u98ce\u9669\uff0c\u9700\u5728\u533b\u5e08\u6307\u5bfc\u4e0b\u8c28\u614e\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u516d\u3001\u4fe1\u8fea\u5229\u5355\u6297<span> Sintilimab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u9002\u7528\u4e8e\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u7528\u4e8e\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u809d\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u8be5\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\u8bc4\u4f30\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u53cd\u5e94\u53ca\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u57fa\u4e8e<span>ORIENT-32<\/span>\u4e34\u5e8a\u7814\u7a76\uff0c\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\uff0c\u91c7\u7528\u9759\u8109\u8f93\u6ce8\u7684\u65b9\u5f0f\u7ed9\u836f\uff0c\u9759\u8109\u8f93\u6ce8\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>200mg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u6cbb\u7597\u524d\u8fdb\u884c\u5305\u62ec\u7532\u72b6\u817a\u529f\u80fd\u3001\u5fc3\u808c\u9176\u7b49\u7684\u57fa\u7ebf\u68c0\u6d4b\uff0c\u5728\u6cbb\u7597\u4e2d\u5b9a\u671f\u968f\u8bbf\u7528\u4e8e\u65e9\u671f\u53d1\u73b0\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u540c\u65f6\u9700\u6ce8\u610f\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u4e5f\u53ef\u80fd\u51fa\u73b0\u4e8e\u6cbb\u7597\u7ed3\u675f\u540e\u3002\u5982\u51fa\u73b0\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\u3002\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002\u4e25\u91cd\u8005\u6216\u8bca\u65ad\u5b58\u7591\u8005\u53ef\u7531\u6d88\u5316\u79d1\u3001\u98ce\u6e7f\u79d1\u3001\u76ae\u80a4\u79d1\u3001\u547c\u5438\u79d1\u3001\u80bf\u7624\u79d1\u7b49\u7ec4\u6210\u7684\u514d\u75ab\u4e0d\u826f\u53cd\u5e94<span>MDT<\/span>\u8fdb\u884c\u4f1a\u8bca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u672c\u54c1\u5c1a\u65e0\u9488\u5bf9\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\uff1b\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u672c\u54c1\u5c1a\u65e0\u9488\u5bf9\u4e2d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u8f7b\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\uff1b\u4e2d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u7684\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u2265<span>10%<\/span>\uff09\u5305\u62ec\u53d1\u70ed\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u75c7\u3001\u4f53\u91cd\u589e\u52a0\u3001\u80ba\u708e\u3001\u4e0a\u547c\u5438\u9053\u611f\u67d3\u3001\u76ae\u75b9\u3001\u8d2b\u8840\u3001\u54b3\u55fd\u3002\u6700\u5e38\u89c1\u7684<span>3<\/span>\u7ea7\u4ee5\u4e0a\u7684\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u4f53\u91cd\u589e\u52a0\u3001\u8d2b\u8840\u3001\u8f93\u6db2\u53cd\u5e94\u3001\u547c\u5438\u9053\u611f\u67d3\u3001\u611f\u67d3\u6027\u80ba\u708e\u3001\u514d\u75ab\u76f8\u5173\u6027\u80ba\u708e\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5c1a\u65e0\u5728<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u53ca\u9752\u5c11\u5e74\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5728\u2265<span>65<\/span>\u5c81\u7684\u8001\u5e74\u60a3\u8005\u4e2d\u5e94\u7528\u6570\u636e\u6709\u9650\uff0c\u5efa\u8bae\u5728\u533b\u751f\u7684\u6307\u5bfc\u4e0b\u614e\u7528\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u5efa\u8bae\u5728\u598a\u5a20\u671f\u95f4\u4f7f\u7528\u672c\u54c1\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56e0\u53ef\u80fd\u5e72\u6270\u672c\u54c1\u836f\u6548\u5b66\u6d3b\u6027\uff0c\u5e94\u907f\u514d\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002\u4f46\u662f\u5982\u679c\u4e3a\u4e86\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u540e\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span style=\"color:red;\"><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e03\u3001\u5361\u745e\u5229\u73e0\u5355\u6297<span> Camrelizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7c89\u9488\u5242\uff1a<span>200mg\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e00\u7ebf\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u60a3\u8005\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u63a5\u53d7\u8fc7\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u548c<span>\/<\/span>\u6216\u542b\u5965\u6c99\u5229\u94c2\u7cfb\u7edf\u5316\u7597\u7684\u665a\u671f\u809d\u7ec6\u80de\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u91c7\u7528\u9759\u8109\u8f93\u6ce8\u7684\u65b9\u5f0f\u7ed9\u836f\uff0c\u9759\u8109\u8f93\u6ce8\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>200mg<\/span>\uff0c\u6bcf<span>2<\/span>\u5468\u6216<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53ea\u8981\u89c2\u5bdf\u5230\u4e34\u5e8a\u83b7\u76ca\uff0c\u5e94\u7ee7\u7eed<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5361\u745e\u5229\u73e0\u5355\u6297<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\uff0c\u76f4\u81f3\u60a3\u8005\u4e0d\u80fd\u8010\u53d7\uff0c<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5373\u4f7f\u8003\u8651\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u53ef\u80fd\uff0c\u4f46<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u60a3\u8005\u4e2a\u4f53\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u7684\u7a0b\u5ea6\u4e0d\u540c\uff0c\u53ef\u6682\u505c\u7ed9\u836f\u6216\u505c\u836f\uff0c\u4e0d\u5efa\u8bae\u5242\u91cf\u8c03\u6574\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u6cbb\u7597\u524d\u8fdb\u884c\u5305\u62ec\u7532\u72b6\u817a\u529f\u80fd\u3001\u5fc3\u808c\u9176\u7b49\u7684\u57fa\u7ebf\u68c0\u6d4b\uff0c\u5728\u6cbb\u7597\u4e2d\u5b9a\u671f\u968f\u8bbf\u7528\u4e8e\u65e9\u671f\u53d1\u73b0\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u3002\u540c\u65f6\u9700\u6ce8\u610f\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u4e5f\u53ef\u80fd\u51fa\u73b0\u4e8e\u6cbb\u7597\u7ed3\u675f\u540e\u3002\u5982\u51fa\u73b0\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\u3002\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002\u53d1\u751f<span>4<\/span>\u7ea7\u6216\u590d\u53d1\u6027<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u867d\u7136\u8fdb\u884c\u6cbb\u7597\u8c03\u6574\u4f46\u4ecd\u6301\u7eed\u5b58\u5728<span>2<\/span>\u7ea7\u6216<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u6c38\u4e45\u6027\u505c\u7528\u5361\u745e\u5229\u73e0\u5355\u6297\u3002\u4e25\u91cd\u8005\u6216\u8bca\u65ad\u5b58\u7591\u8005\u53ef\u7531\u6d88\u5316\u79d1\u3001\u98ce\u6e7f\u79d1\u3001\u76ae\u80a4\u79d1\u3001\u547c\u5438\u79d1\u3001\u80bf\u7624\u79d1\u7b49\u7ec4\u6210\u7684\u514d\u75ab\u4e0d\u826f\u53cd\u5e94<span>MDT<\/span>\u8fdb\u884c\u4f1a\u8bca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5728\u2265<span>65<\/span>\u5c81\u7684\u8001\u5e74\u60a3\u8005\u4e2d\u5e94\u7528\u6570\u636e\u6709\u9650\uff0c\u5efa\u8bae\u5728\u533b\u5e08\u7684\u6307\u5bfc\u4e0b\u614e\u7528\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002\u4e0d\u5efa\u8bae\u5728\u598a\u5a20\u671f\u95f4\u4f7f\u7528\u672c\u54c1\u6cbb\u7597\u3002\u76ee\u524d\u672c\u54c1\u5c1a\u65e0\u9488\u5bf9\u4e2d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u4e2d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\uff0c\u8f7b\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u5e08\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002\u76ee\u524d\u672c\u54c1\u5c1a\u65e0\u9488\u5bf9\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\uff0c\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u4f7f\u7528\u672c\u54c1\u4e4b\u524d\u5e94\u907f\u514d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u836f\u7269\u53ef\u80fd\u4f1a\u5f71\u54cd\u672c\u54c1\u7684\u836f\u6548\u5b66\u6d3b\u6027\u53ca\u7597\u6548\u3002\u4f46\u5728\u672c\u54c1\u5f00\u59cb\u7ed9\u836f\u540e\uff0c\u53ef\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u514d\u75ab\u4ecb\u5bfc\u6027\u4e0d\u826f\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u7684\u5904\u7406\uff1a\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c<span>70%<\/span>\uff5e<span>80%<\/span>\u53d1\u751f\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u3002\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\uff0c\u5927\u591a\u53d1\u751f\u5728\u4f53\u8868\u76ae\u80a4\uff0c\u5c11\u6570\u53ef\u89c1\u4e8e\u53e3\u8154\u9ecf\u819c\u3001\u9f3b\u8154\u9ecf\u819c\u4ee5\u53ca\u773c\u7751\u7ed3\u819c\u3002\u53d1\u751f\u4e8e\u76ae\u80a4\u7684\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\uff0c\u521d\u59cb\u591a\u8868\u73b0\u4e3a\u4f53\u8868\u9c9c\u7ea2\u8272\u70b9\u72b6\u7269\uff0c\u76f4\u5f84\u2264<span>2mm<\/span>\uff0c\u968f\u7740\u7528\u836f\u6b21\u6570\u589e\u52a0\uff0c\u75c5\u53d8\u8303\u56f4\u53ef\u9010\u6e10\u589e\u5927\uff0c\u591a\u4e3a\u7ed3\u8282\u72b6\uff0c\u4e5f\u6709\u6591\u7247\u72b6\uff0c\u989c\u8272\u9c9c\u7ea2\u6216\u6697\u7ea2\uff0c\u9700\u89c2\u5bdf\u4e34\u5e8a\u75c7\u72b6\u548c\u4f53\u5f81\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5f53\u60a3\u8005\u51fa\u73b0\u8be5\u4e0d\u826f\u53cd\u5e94\u65f6\uff0c\u5e94\u907f\u514d\u6293\u6320\u6216\u6469\u64e6\uff0c\u6613\u6469\u64e6\u90e8\u4f4d\u53ef\u7528\u7eb1\u5e03\u4fdd\u62a4\u4ee5\u907f\u514d\u51fa\u8840\uff0c\u540c\u65f6\u5e94\u8054\u7cfb\u4e3b\u7ba1\u533b\u5e08\uff0c\u83b7\u5f97\u6070\u5f53\u7684\u5904\u7406\u5efa\u8bae\u3002\u7834\u6e83\u51fa\u8840\u8005\u53ef\u91c7\u7528\u5c40\u90e8\u538b\u8feb\u6b62\u8840\uff0c\u6216\u91c7\u53d6\u5982\u6fc0\u5149\u6216\u624b\u672f\u5207\u9664\u7b49\u5c40\u90e8\u6cbb\u7597\uff1b\u5e76\u53d1\u611f\u67d3\u8005\u5e94\u7ed9\u4e88\u6297\u611f\u67d3\u6cbb\u7597\u3002\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u53ef\u80fd\u5728\u76ae\u80a4\u4ee5\u5916\u7684\u5176\u4ed6\u7ec4\u7ec7\u53d1\u751f\uff08\u5305\u62ec\u7751\u7ed3\u819c\u3001\u5185\u5916\u7726\u3001\u53e3\u8154\u9ecf\u819c\u3001\u54bd\u5589\u7b49\u9ecf\u819c\u6216\u5176\u4ed6\u810f\u5668\uff09\uff0c\u5e94\u6839\u636e\u81ea\u67e5\u75c7\u72b6\u548c\u4f53\u5f81\uff0c\u5fc5\u8981\u65f6\u8fdb\u884c\u76f8\u5e94\u7684\u533b\u5b66\u68c0\u67e5\uff0c\u5982\u5927\u4fbf\u6f5c\u8840\u3001\u5185\u7aa5\u955c\u53ca\u5f71\u50cf\u5b66\u68c0\u67e5\uff08\u5177\u4f53\u76f8\u5173\u5185\u5bb9\u8be6\u89c1\u300a\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u4fe1\u606f\u6536\u96c6\u53ca\u98ce\u9669\u7ba1\u7406\u8ba1\u5212\u300b\uff09\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u516b\u3001\u66ff\u96f7\u5229\u73e0\u5355\u6297<span>Tislelizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u81f3\u5c11\u7ecf\u8fc7\u4e00\u79cd\u5168\u8eab\u6cbb\u7597\u7684\u809d\u7ec6\u80de\u764c\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u8be5\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\u8bc4\u4f30\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u53cd\u5e94\u53ca\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u91c7\u7528\u9759\u8109\u8f93\u6ce8\u7684\u65b9\u5f0f\u7ed9\u836f\uff0c\u9759\u8109\u8f93\u6ce8\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>200mg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u9002\u5e94\u8bc1\u662f\u57fa\u4e8e\u4e00\u9879\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\u548c\u603b\u751f\u5b58\u671f\u7ed3\u679c\u7ed9\u4e88\u7684\u9644\u6761\u4ef6\u6279\u51c6\u3002\u672c\u9002\u5e94\u8bc1\u7684\u5b8c\u5168\u6279\u51c6\u5c06\u53d6\u51b3\u4e8e\u6b63\u5728\u5f00\u5c55\u4e2d\u7684\u786e\u8bc1\u6027\u968f\u673a\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\u80fd\u5426\u8bc1\u5b9e\u672c\u54c1\u6cbb\u7597\u76f8\u5bf9\u5e94\u6807\u51c6\u6cbb\u7597\u7684\u663e\u8457\u4e34\u5e8a\u83b7\u76ca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u6cbb\u7597\u524d\u8fdb\u884c\u5305\u62ec\u7532\u72b6\u817a\u529f\u80fd\u3001\u5fc3\u808c\u9176\u7b49\u7684\u57fa\u7ebf\u68c0\u6d4b\uff0c\u5728\u6cbb\u7597\u4e2d\u5b9a\u671f\u968f\u8bbf\u7528\u4e8e\u65e9\u671f\u53d1\u73b0\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u3002\u540c\u65f6\u9700\u6ce8\u610f\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u4e5f\u53ef\u80fd\u51fa\u73b0\u4e8e\u6cbb\u7597\u7ed3\u675f\u540e\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\uff0c\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\u3002\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002\u4e25\u91cd\u8005\u6216\u8bca\u65ad\u5b58\u7591\u8005\u53ef\u7531\u6d88\u5316\u79d1\u3001\u98ce\u6e7f\u79d1\u3001\u76ae\u80a4\u79d1\u3001\u547c\u5438\u79d1\u3001\u80bf\u7624\u79d1\u7b49\u7ec4\u6210\u7684\u514d\u75ab\u4e0d\u826f\u53cd\u5e94<span>MDT<\/span>\u8fdb\u884c\u4f1a\u8bca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u5c1a\u65e0\u9488\u5bf9\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u5c1a\u65e0\u9488\u5bf9\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u54fa\u4e73\u671f\u5987\u5973\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u53ca\u672b\u6b21\u7ed9\u836f\u540e\u81f3\u5c11<span>5<\/span>\u4e2a\u6708\u5185\u505c\u6b62\u54fa\u4e73\u3002\u80b2\u9f84\u671f\u5987\u5973\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u671f\u95f4\uff0c\u4ee5\u53ca\u6700\u540e\u4e00\u6b21\u672c\u54c1\u7ed9\u836f\u540e\u81f3\u5c11<span>5<\/span>\u4e2a\u6708\u5185\u5e94\u91c7\u7528\u6709\u6548\u907f\u5b55\u63aa\u65bd\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56e0\u53ef\u80fd\u5e72\u6270\u672c\u54c1\u836f\u6548\u5b66\u6d3b\u6027\uff0c\u5e94\u907f\u514d\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002\u4f46\u662f\u5982\u679c\u4e3a\u4e86\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u540e\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e5d\u3001\u5e15\u535a\u5229\u73e0\u5355\u6297<span> Pembrolizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>4ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7531\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u8bc4\u4f30\u4e3a<span>PD-L1<\/span>\u7efc\u5408\u9633\u6027\u8bc4\u5206\uff08<span>CPS<\/span>\uff09\u2265<span>10<\/span>\u3001\u65e2\u5f80\u4e00\u7ebf\u5168\u8eab\u6cbb\u7597\u5931\u8d25\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.KRAS<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u3001<span>NRAS<\/span>\u548c<span>BRAF<\/span>\u57fa\u56e0\u5747\u4e3a\u91ce\u751f\u578b\uff0c\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ad8\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\uff08<span>MSI-H<\/span>\uff09\u6216\u9519\u914d\u4fee\u590d\u57fa\u56e0\u7f3a\u9677\u578b\uff08<span>dMMR<\/span>\uff09\u7ed3\u76f4\u80a0\u764c\uff08<span>CRC<\/span>\uff09\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u57fa\u4e8e<span>KEYNOTE-181<\/span>\u548c<span>KEYNOTE-177<\/span>\u7814\u7a76\u7ed3\u679c\uff0c<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u83b7\u6279\u7684\u5242\u91cf<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u662f<span>200mg<\/span>\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6216<span>400mg<\/span>\u6bcf<span>6<\/span>\u5468\u4e00\u6b21\uff0c\u901a\u8fc7\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\uff0c\u6bcf\u6b21\u6301\u7eed\u81f3\u5c11<span>30<\/span>\u5206\u949f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53ea\u8981\u89c2\u5bdf\u5230\u4e34\u5e8a\u83b7\u76ca\uff0c\u5e94\u7ee7\u7eed<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\uff0c\u76f4\u81f3\u60a3\u8005\u4e0d\u80fd\u8010\u53d7\uff0c<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\uff0c<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5373\u4f7f\u8003\u8651\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u53ef\u80fd\uff0c\u4f46<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u505c\u836f\uff0c\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53d1\u751f<span>4<\/span>\u7ea7\u6216\u590d\u53d1\u6027<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u867d\u7136\u8fdb\u884c\u6cbb\u7597\u8c03\u6574\u4f46\u4ecd\u6301\u7eed\u5b58\u5728<span>2<\/span>\u7ea7\u6216<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u6c38\u4e45\u6027\u505c\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u3002\u5982\u679c\u51fa\u73b0\u4efb\u4f55\u91cd\u5ea6\u3001\u590d\u53d1\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u4ee5\u53ca\u4efb\u4f55\u5371\u53ca\u751f\u547d\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5fc5\u987b\u6c38\u4e45\u505c\u6b62\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8001\u5e74\u60a3\u8005\uff08\u2265<span>65<\/span>\u5c81\uff09\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u6570\u636e\u6709\u9650\u3002\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u5c1a\u672a\u5728\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u8fdb\u884c\u672c\u54c1\u7684\u76f8\u5173\u7814\u7a76\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u4f7f\u7528\u672c\u54c1\u4e4b\u524d\u5e94\u907f\u514d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u836f\u7269\u53ef\u80fd\u4f1a\u5f71\u54cd\u672c\u54c1\u7684\u836f\u6548\u5b66\u6d3b\u6027\u53ca\u7597\u6548\u3002\u4f46\u5728\u672c\u54c1\u5f00\u59cb\u7ed9\u836f\u540e\uff0c\u53ef\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u514d\u75ab\u4ecb\u5bfc\u6027\u4e0d\u826f\u53cd\u5e94\u3002\u5728\u60a3\u8005\u63a5\u53d7\u514d\u75ab\u6291\u5236\u5242\u91cf\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u671f\u95f4\uff0c\u4e0d\u53ef\u91cd\u65b0\u4f7f\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u53ef\u80fd\u5f15\u8d77\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5efa\u8bae\u6cbb\u7597\u524d\u8fdb\u884c\u5305\u62ec\u7532\u72b6\u817a\u529f\u80fd\u3001\u5fc3\u808c\u9176\u7b49\u7684\u57fa\u7ebf\u68c0\u6d4b\uff0c\u5728\u6cbb\u7597\u4e2d\u5b9a\u671f\u968f\u8bbf\u7528\u4e8e\u65e9\u671f\u53d1\u73b0\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u3002\u56e0\u4e3a\u4e0d\u826f\u53cd\u5e94\u53ef\u80fd\u5728\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u671f\u95f4\u6216\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u505c\u6b62\u540e\u7684\u4efb\u4f55\u65f6\u95f4\u53d1\u751f\uff0c\u5e94\u6301\u7eed\u8fdb\u884c\u60a3\u8005\u76d1\u6d4b\uff08\u81f3\u5c11\u81f3\u672b\u6b21\u7ed9\u836f\u540e<span>5<\/span>\u4e2a\u6708\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u5e94\u6682\u65f6\u505c\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\uff0c\u5e76\u5e94\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u3002\u5f53\u514d\u75ab\u76f8\u5173\u7684\u4e0d\u826f\u53cd\u5e94\u6539\u5584\u81f3\u2264<span>1<\/span>\u7ea7\u65f6\uff0c\u9700\u9010\u6b65\u51cf\u91cf\u81f3\u505c\u836f\u3002\u57fa\u4e8e\u6709\u9650\u7684\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff0c\u53d1\u751f\u7cd6\u76ae\u8d28\u6fc0\u7d20\u65e0\u6cd5\u63a7\u5236\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u65f6\u53ef\u4ee5\u8003\u8651\u4f7f\u7528\u5176\u4ed6\u5168\u8eab\u6027\u514d\u75ab\u6291\u5236\u5242\u3002\u5982\u679c\u4e0d\u826f\u53cd\u5e94\u4fdd\u6301\u5728\u2264<span>1<\/span>\u7ea7\uff0c\u4e14\u7cd6\u76ae\u8d28\u6fc0\u7d20\u5242\u91cf\u5df2\u964d\u81f3\u6bcf\u5929\u2264<span>10mg<\/span>\u6cfc\u5c3c\u677e\u6216\u7b49\u6548\u5242\u91cf\uff0c\u5219\u53ef\u5728\u6700\u540e\u4e00\u6b21\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ed9\u836f\u540e<span>12<\/span>\u5468\u5185\u91cd\u65b0\u5f00\u59cb\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u3002\u4e25\u91cd\u8005\u6216\u8bca\u65ad\u5b58\u7591\u8005\u53ef\u7531\u6d88\u5316\u79d1\u3001\u98ce\u6e7f\u79d1\u3001\u76ae\u80a4\u79d1\u3001\u547c\u5438\u79d1\u3001\u80bf\u7624\u79d1\u7b49\u7ec4\u6210\u7684\u514d\u75ab\u4e0d\u826f\u53cd\u5e94<span>MDT<\/span>\u8fdb\u884c\u4f1a\u8bca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u3001\u66f2\u59a5\u73e0\u5355\u6297<span> Trastuzumab<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u5242\uff1a<span>440mg<\/span>\uff08<span>20ml<\/span>\uff09<span>\/<\/span>\u74f6<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u8054\u5408\u5361\u57f9\u4ed6\u6ee8\u6216\u6c1f\u5c3f\u5627\u5576\u548c\u987a\u94c2\u9002\u7528\u4e8e\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u9488\u5bf9\u8f6c\u79fb\u6027\u75be\u75c5\u6cbb\u7597\u7684<span>HER2<\/span>\u9633\u6027\u7684\u8f6c\u79fb\u6027\u80c3\u817a\u764c\u6216\u80c3\u98df\u7ba1\u4ea4\u754c\u817a\u764c\u60a3\u8005\uff0c\u5bf9\u4e8e\u987a\u94c2\u548c\u6c1f\u5c3f\u5627\u5576\u7c7b\u8fdb\u5c55\uff0c\u800c\u672a\u4f7f\u7528\u8fc7\u66f2\u59a5\u73e0\u5355\u6297\u7684<span>HER2<\/span>\u9633\u6027\u7684\u8f6c\u79fb\u6027\u80c3\u764c\u60a3\u8005\uff0c\u53ef\u4ee5\u8003\u8651\u66f2\u59a5\u73e0\u5355\u6297\u8054\u5408\u5176\u4ed6\u6709\u6548\u7684\u5316\u7597\u836f\u7269\u6cbb\u7597\uff1b\u66f2\u59a5\u73e0\u5355\u6297\u53ea\u80fd\u7528\u4e8e<span>HER2<\/span>\u9633\u6027\u7684\u8f6c\u79fb\u6027\u80c3\u764c\u60a3\u8005\uff0c<span>HER2<\/span>\u9633\u6027\u7684\u5b9a\u4e49\u4e3a\u4f7f\u7528\u5df2\u9a8c\u8bc1\u7684\u68c0\u6d4b\u65b9\u6cd5\u5f97\u5230\u7684<span>IHC3+<\/span>\u6216<span>IHC2+\/FISH+<\/span>\u7ed3\u679c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u672c\u54c1\u6cbb\u7597\u524d\uff0c\u5e94\u8fdb\u884c<span>HER2<\/span>\u68c0\u6d4b\uff0c\u76f8\u5173\u68c0\u6d4b\u5e94\u4f7f\u7528\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66f2\u59a5\u73e0\u5355\u6297\u5f00\u59cb\u6cbb\u7597\u524d\u5e94\u8fdb\u884c\u5de6\u5ba4\u5c04\u8840\u5206\u6570\uff08<span>LVEF<\/span>\uff09\u7684\u68c0\u6d4b\uff0c\u6cbb\u7597\u671f\u95f4\u987b\u5bc6\u5207\u76d1\u6d4b<span>LVEF<\/span>\u3002<span>LVEF<\/span>\u8f83\u6cbb\u7597\u524d\u7edd\u5bf9\u6570\u503c\u4e0b\u964d\u2265<span>16%<\/span>\uff0c\u6216<span>LVEF<\/span>\u4f4e\u4e8e\u8be5\u68c0\u6d4b\u4e2d\u5fc3\u6b63\u5e38\u8303\u56f4\u5e76\u4e14<span>LVEF<\/span>\u8f83\u6cbb\u7597\u524d\u7edd\u5bf9\u6570\u503c\u4e0b\u964d\u2265<span>10%<\/span>\uff0c\u5e94\u505c\u6b62\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u81f3\u5c11<span>4<\/span>\u5468\uff0c\u5e76\u6bcf<span>4<\/span>\u5468\u68c0\u6d4b\u4e00\u6b21<span>LVEF<\/span>\u3002<span>4<\/span>\uff5e<span>8<\/span>\u5468\u5185<span>LVEF<\/span>\u56de\u5347\u81f3\u6b63\u5e38\u8303\u56f4\u6216<span>LVEF<\/span>\u8f83\u6cbb\u7597\u524d\u7edd\u5bf9\u6570\u503c\u4e0b\u964d\u2264<span>15%<\/span>\uff0c\u53ef\u6062\u590d\u4f7f\u7528\u66f2\u59a5\u73e0\u5355\u6297\u3002<span>LVEF<\/span>\u6301\u7eed\u4e0b\u964d\uff08\uff1e<span>8<\/span>\u5468\uff09\uff0c\u6216\u8005\u4e09\u6b21\u4ee5\u4e0a\u56e0\u5fc3\u810f\u6bd2\u6027\u800c\u505c\u6b62\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\uff0c\u5e94\u6c38\u4e45\u505c\u6b62\u4f7f\u7528\u66f2\u59a5\u73e0\u5355\u6297\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80c3\u764c\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u60a3\u8005\u51fa\u73b0\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\u3001\u5de6\u5fc3\u5ba4\u529f\u80fd\u660e\u663e\u4e0b\u964d\u3001\u4e25\u91cd\u7684\u8f93\u6ce8\u53cd\u5e94\u548c\u80ba\u90e8\u53cd\u5e94\u65f6\uff0c\u8981\u4e2d\u65ad\u6216\u505c\u6b62\u66f2\u59a5\u73e0\u5355\u6297\u7684\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5341\u4e00\u3001\u963f\u5e15\u66ff\u5c3c<span> Apatinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>0.25g<\/span>\u3001<span>0.375g<\/span>\u3001<span>0.425g<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7<span>2<\/span>\u79cd\u7cfb\u7edf\u5316\u7597\u540e\u8fdb\u5c55\u6216\u590d\u53d1\u7684\u665a\u671f\u80c3\u817a\u764c\u6216\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c\u60a3\u8005\uff0c\u4e14\u60a3\u8005\u63a5\u53d7\u963f\u5e15\u66ff\u5c3c\u6cbb\u7597\u65f6\u4e00\u822c\u72b6\u51b5\u826f\u597d\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u836f\u54c1\u8bf4\u660e\u4e66\u63a8\u8350\u5242\u91cf\u4e3a<span>850mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u3002\u5bf9\u4e8e\u4f53\u529b\u72b6\u6001\u8bc4\u5206<span>ECOG<\/span>\u2265<span>2<\/span>\u3001\u56db\u7ebf\u5316\u7597\u4ee5\u540e\u3001\u80c3\u90e8\u539f\u53d1\u764c\u7076\u6ca1\u6709\u5207\u9664\u3001\u9aa8\u9ad3\u529f\u80fd\u50a8\u5907\u5dee\u3001\u5e74\u8001\u4f53\u5f31\u6216\u7626\u5c0f\u7684\u5973\u6027\u60a3\u8005\uff0c\u4e3a\u4e86\u786e\u4fdd\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u63d0\u9ad8\u4f9d\u4ece\u6027\uff0c\u53ef\u4ee5\u9002\u5f53\u964d\u4f4e\u8d77\u59cb\u5242\u91cf\uff0c\u5148\u4ece<span>250mg<\/span>\u5f00\u59cb\u670d\u836f\uff0c\u670d\u7528<span>1<\/span>\uff5e<span>2<\/span>\u5468\u540e\u518d\u914c\u60c5\u589e\u52a0\u5242\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u51fa\u73b0<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\u65f6\uff0c\u5efa\u8bae\u6682\u505c\u7528\u836f\uff0c\u5e76\u5bf9\u75c7\u5904\u7406\uff0c\u5f85\u75c7\u72b6\u7f13\u89e3\u6062\u590d\u5230<span>1<\/span>\u7ea7\u4ee5\u5185\uff0c\u968f\u540e\u964d\u4f4e\u5242\u91cf\u670d\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u7279\u522b\u5173\u6ce8\u8840\u538b\u5347\u9ad8\u3001\u86cb\u767d\u5c3f\u3001\u624b\u8db3\u76ae\u80a4\u53cd\u5e94\u3001\u51fa\u8840\u3001\u5fc3\u810f\u6bd2\u6027\u3001\u809d\u810f\u6bd2\u6027\u7b49\u4e0d\u826f\u53cd\u5e94\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u614e\u4e0e\u5ef6\u957f<span>QTc<\/span>\u95f4\u671f\u7684\u836f\u7269\u540c\u65f6\u4f7f\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e8c\u3001<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297<span> Nivolumab<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:26.6pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a\u6ce8\u5c04\u6db2\uff1a<span>40mg<\/span>\uff08<span>4ml<\/span>\uff09<span>\/<\/span>\u74f6\u3001<span>100mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8054\u5408\u542b\u6c1f\u5c3f\u5627\u5576\u548c\u94c2\u7c7b\u836f\u7269\u5316\u7597\u9002\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80c3\u764c\u3001\u80c3\u98df\u7ba1\u8fde\u63a5\u90e8\u764c\u6216\u98df\u7ba1\u817a\u764c\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e24\u79cd\u6216\u4e24\u79cd\u4ee5\u4e0a\u5168\u8eab\u6027\u6cbb\u7597\u65b9\u6848\u7684\u665a\u671f\u6216\u590d\u53d1\u6027\u80c3\u6216\u80c3\u98df\u7ba1\u8fde\u63a5\u90e8\u817a\u764c\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5355\u836f\u6cbb\u7597\u63a8\u8350\u5242\u91cf\u4e3a<span>3mg\/kg<\/span>\u6216<span>240mg<\/span>\u56fa\u5b9a\u5242\u91cf\uff0c\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff0c\u9759\u8109\u8f93\u6ce8<span>30<\/span>\u5206\u949f\u3002\u8054\u5408\u542b\u6c1f\u5c3f\u5627\u5576\u548c\u94c2\u7c7b\u836f\u7269\u5316\u7597\uff0c\u63a8\u8350\u5242\u91cf\u4e3a<span>360 mg<\/span>\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c\u9759\u8109\u6ce8\u5c04\u6301\u7eed<span>30<\/span>\u5206\u949f\u6216\u672c\u54c1<span>240mg<\/span>\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff0c\u9759\u8109\u6ce8\u5c04\u6301\u7eed<span>30<\/span>\u5206\u949f\u3002\u6700\u957f\u6cbb\u7597\u6301\u7eed\u65f6\u95f4\u4e3a<span>24<\/span>\u4e2a\u6708\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53ea\u8981\u89c2\u5bdf\u5230\u4e34\u5e8a\u83b7\u76ca\uff0c\u5e94\u7ee7\u7eed\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\uff0c\u76f4\u81f3\u60a3\u8005\u4e0d\u80fd\u8010\u53d7\uff0c\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u8003\u8651\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u53ef\u80fd\uff0c\u4f46\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u6682\u505c\u7ed9\u836f\u6216\u505c\u836f\uff0c\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53d1\u751f<span>4<\/span>\u7ea7\u6216\u590d\u53d1\u6027<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u867d\u7136\u8fdb\u884c\u6cbb\u7597\u8c03\u6574\u4f46\u4ecd\u6301\u7eed\u5b58\u5728<span>2<\/span>\u7ea7\u6216<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u53d1\u751f<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u80ba\u708e\u3001\u809d\u708e\u3001\u5fc3\u808c\u708e\uff0c\u5e94\u6c38\u4e45\u6027\u505c\u7528\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u3002\u5982\u679c\u51fa\u73b0\u4efb\u4f55\u91cd\u5ea6\u3001\u590d\u53d1\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u4ee5\u53ca\u4efb\u4f55\u5371\u53ca\u751f\u547d\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5fc5\u987b\u6c38\u4e45\u505c\u6b62\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8001\u5e74\u60a3\u8005\uff08\u2265<span>65<\/span>\u5c81\uff09\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u6570\u636e\u6709\u9650\u3002\u8f7b\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u6ca1\u6709\u5bf9\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u8fdb\u884c\u672c\u54c1\u7684\u76f8\u5173\u7814\u7a76\uff0c\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\uff08\u603b\u80c6\u7ea2\u7d20\u3001<span>ALT<\/span>\u6216<span>AST<\/span>\uff1e<span>3<\/span>\u500d\u6b63\u5e38\u503c\u4e0a\u9650\uff09\u60a3\u8005\u614e\u7528\u672c\u54c1\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u4f7f\u7528\u672c\u54c1\u4e4b\u524d\u5e94\u907f\u514d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u836f\u7269\u53ef\u80fd\u4f1a\u5f71\u54cd\u672c\u54c1\u7684\u836f\u6548\u5b66\u6d3b\u6027\u53ca\u7597\u6548\u3002\u4f46\u5728\u672c\u54c1\u5f00\u59cb\u7ed9\u836f\u540e\uff0c\u53ef\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u514d\u75ab\u4ecb\u5bfc\u6027\u4e0d\u826f\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u53ef\u80fd\u5f15\u8d77\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5efa\u8bae\u6cbb\u7597\u524d\u8fdb\u884c\u5305\u62ec\u7532\u72b6\u817a\u529f\u80fd\u3001\u5fc3\u808c\u9176\u7b49\u7684\u57fa\u7ebf\u68c0\u6d4b\uff0c\u5728\u6cbb\u7597\u4e2d\u5b9a\u671f\u968f\u8bbf\u7528\u4e8e\u65e9\u671f\u53d1\u73b0\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56e0\u4e3a\u4e0d\u826f\u53cd\u5e94\u53ef\u80fd\u5728\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u671f\u95f4\u6216\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u505c\u6b62\u540e\u7684\u4efb\u4f55\u65f6\u95f4\u53d1\u751f\uff0c\u5e94\u6301\u7eed\u8fdb\u884c\u60a3\u8005\u76d1\u6d4b\uff08\u81f3\u5c11\u81f3\u672b\u6b21\u7ed9\u836f\u540e<span>5<\/span>\u4e2a\u6708\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u5e94\u6682\u505c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u5e76\u7ed9\u4e88\u7cd6\u76ae\u8d28\u6fc0\u7d20\u3002\u82e5\u4f7f\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u514d\u75ab\u6291\u5236\u7597\u6cd5\u6cbb\u7597\u4e0d\u826f\u53cd\u5e94\uff0c\u75c7\u72b6\u6539\u5584\u540e\uff0c\u9700\u9010\u6e10\u51cf\u91cf\u81f3\u505c\u836f\uff0c\u5feb\u901f\u51cf\u91cf\u53ef\u80fd\u5f15\u8d77\u4e0d\u826f\u53cd\u5e94\u6076\u5316\u6216\u590d\u53d1\u3002\u5982\u679c\u4f7f\u7528\u4e86\u7cd6\u76ae\u8d28\u6fc0\u7d20\u4f46\u4ecd\u6076\u5316\u6216\u65e0\u6539\u5584\uff0c\u5219\u5e94\u589e\u52a0\u975e\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6027\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u3002\u4e25\u91cd\u8005\u6216\u8bca\u65ad\u5b58\u7591\u8005\u53ef\u7531\u6d88\u5316\u79d1\u3001\u98ce\u6e7f\u79d1\u3001\u76ae\u80a4\u79d1\u3001\u547c\u5438\u79d1\u3001\u80bf\u7624\u79d1\u7b49\u7ec4\u6210\u7684\u514d\u75ab\u4e0d\u826f\u53cd\u5e94<span>MDT<\/span>\u8fdb\u884c\u4f1a\u8bca\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u60a3\u8005\u63a5\u53d7\u514d\u75ab\u6291\u5236\u5242\u91cf\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u671f\u95f4\uff0c\u4e0d\u53ef\u91cd\u65b0\u4f7f\u7528\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e09\u3001\u7ef4\u8fea\u897f\u59a5\u5355\u6297<span> DisitamabVedotin<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51bb\u5e72\u5236\u5242\uff1a<span>60mg\/<\/span>\u652f<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u81f3\u5c11\u63a5\u53d7\u8fc7<span>2<\/span>\u4e2a\u7cfb\u7edf\u5316\u7597\u7684<span>HER2<\/span>\u8fc7\u8868\u8fbe\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80c3\u764c\uff08\u5305\u62ec\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c\uff09\u7684\u60a3\u8005\u3002<span>HER2<\/span>\u8fc7\u8868\u8fbe\u5b9a\u4e49\u4e3a<span>HER2<\/span>\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u68c0\u67e5\u7ed3\u679c\u4e3a<span>2+<\/span>\u6216<span>3+<\/span>\uff0c\u65e0\u8bba<span>FiSH\/CiSH<\/span>\u6269\u589e\u4e0e\u5426\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u672c\u54c1\u6cbb\u7597\u524d\uff0c\u5e94\u8fdb\u884c<span>HER2<\/span>\u68c0\u6d4b\uff0c\u76f8\u5173\u68c0\u6d4b\u5e94\u4f7f\u7528\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a<span>2.5mg\/kg<\/span>\uff0c\u6bcf\u4e24\u5468\u4e00\u6b21\uff0c\u9759\u8109\u6ef4\u6ce8\uff0c\u5386\u65f6<span>30<\/span>\uff5e<span>90<\/span>\u5206\u949f\uff08\u901a\u5e38\u5efa\u8bae<span>60<\/span>\u5206\u949f\u5de6\u53f3\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8be5\u9002\u5e94\u8bc1\u662f\u57fa\u4e8e\u4e00\u9879<span>HER2<\/span>\u8fc7\u8868\u8fbe\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80c3\u764c\u60a3\u8005\uff08\u5305\u62ec\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c\uff09\u7684\u2161\u671f\u5355\u81c2\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u7ed9\u4e88\u7684\u9644\u6761\u4ef6\u6279\u51c6\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e38\u89c1\u7684\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u7c7b\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u8840\u6db2\u5b66\u5f02\u5e38\u3001\u8f6c\u6c28\u9176\u5347\u9ad8\u3002\u5e38\u89c1\u7684\u4e34\u5e8a\u75c7\u72b6\u3001\u4f53\u5f81\u7c7b\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u8131\u53d1\u3001\u4e4f\u529b\u3001\u611f\u89c9\u51cf\u9000\u7b49\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u60a3\u8005\u53d1\u751f\u4e0e\u836f\u7269\u76f8\u5173\u7684\u2265<span>3<\/span>\u7ea7\u8840\u6db2\u5f02\u5e38\uff0c\u5efa\u8bae\u6682\u505c\u6cbb\u7597\uff0c\u5bf9\u75c7\u6cbb\u7597\uff0c\u6bcf\u5468\u4e24\u6b21\u8fdb\u884c\u8840\u6db2\u5b66\u68c0\u67e5\uff0c\u76f4\u81f3\u6062\u590d\u81f3<span> CTCAE<\/span>\u2264<span>1<\/span>\u7ea7\u6216\u5f00\u59cb\u6cbb\u7597\u524d\u7684\u6c34\u5e73\uff0c\u82e5\u6062\u590d\u7528\u836f\u540e\u518d\u6b21\u53d1\u751f\u4e0d\u826f\u53cd\u5e94\uff0c\u5219\u5e94\u8c03\u6574\u7ed9\u836f\u5242\u91cf\u3002\u5982\u679c\u60a3\u8005\u5728\u6682\u505c\u7528\u836f<span>28<\/span>\u5929\u540e\u4ecd\u672a\u6062\u590d\u81f3<span> CTCAE<\/span>\u2264<span>1<\/span>\u7ea7\u6216\u5f00\u59cb\u6cbb\u7597\u524d\u7684\u6c34\u5e73\uff0c\u5219\u5efa\u8bae\u505c\u6b62\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u60a3\u8005\u53d1\u751f\u4e0e\u836f\u7269\u76f8\u5173\u7684\u2265<span>3<\/span>\u7ea7\u8f6c\u6c28\u9176\u5347\u9ad8\uff0c\u5efa\u8bae\u6682\u505c\u6cbb\u7597\uff0c\u5bf9\u75c7\u6cbb\u7597\uff0c\u6bcf\u5468\u4e24\u6b21\u8fdb\u884c\u8840\u751f\u5316\u68c0\u67e5\uff0c\u76f4\u81f3\u6062\u590d\u81f3<span> CTCAE<\/span>\u2264<span>1<\/span>\u7ea7\u6216\u5f00\u59cb\u6cbb\u7597\u524d\u7684\u6c34\u5e73\uff0c\u82e5\u6062\u590d\u7528\u836f\u540e\u518d\u6b21\u53d1\u751f\u4e0d\u826f\u53cd\u5e94\uff0c\u5219\u5e94\u8c03\u6574\u7ed9\u836f\u5242\u91cf\u3002\u5982\u679c\u60a3\u8005\u5728\u6682\u505c\u7528\u836f<span>28<\/span>\u5929\u540e\u4ecd\u672a\u6062\u590d\u81f3<span> CTCAE<\/span>\u2264<span>1<\/span>\u7ea7\u6216\u5f00\u59cb\u6cbb\u7597\u524d\u7684\u6c34\u5e73\uff0c\u5219\u5efa\u8bae\u505c\u6b62\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u60a3\u8005\u53d1\u751f\u4e86\u836f\u7269\u76f8\u5173\u7684\u611f\u89c9\u5f02\u5e38\uff08\u5982\u9ebb\u6728\u7b49\uff09\uff0c\u4e14\u5728\u6682\u505c\u7528\u836f<span>28<\/span>\u5929\u540e\u4ecd\u672a\u6062\u590d\u81f3\u53ef\u7ee7\u7eed\u7ed9\u836f\u7684\u6c34\u5e73\uff0c\u5efa\u8bae\u505c\u6b62\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002\u76ee\u524d\u5c1a\u672a\u8003\u5bdf\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u5bf9\u672c\u54c1\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u5f71\u54cd\u3002\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\uff0c\u76ee\u524d\u5c1a\u672a\u8bc4\u4f30\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u836f\u4ee3\u52a8\u529b\u5b66\uff0c\u5c1a\u65e0\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c1a\u672a\u786e\u7acb\u672c\u54c1\u5728<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u53ca\u9752\u5c11\u5e74\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u2265<span>65<\/span>\u5c81\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u4e0e\u6574\u4f53\u4eba\u7fa4\u76f8\u6bd4\u672a\u89c1\u660e\u663e\u5dee\u5f02\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u56db\u3001\u4f0a\u9a6c\u66ff\u5c3c<span> Imatinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08<span>1<\/span>\uff09\u7247\u5242\uff1a<span>100mg<\/span>\u3001<span>400mg<\/span>\uff1b\uff08<span>2<\/span>\uff09\u80f6\u56ca\uff1a<span>50mg<\/span>\u3001<span>100mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u6cbb\u7597\u4e0d\u80fd\u5207\u9664\u548c<span>\/<\/span>\u6216\u53d1\u751f\u8f6c\u79fb\u7684\u80c3\u80a0\u95f4\u8d28\u7624\u6210\u4eba\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e<span>C-Kit<\/span>\uff08<span>CD117<\/span>\uff09\u9633\u6027\u80c3\u80a0\u95f4\u8d28\u7624\u624b\u672f\u5207\u9664\u540e\u5177\u6709\u660e\u663e\u590d\u53d1\u98ce\u9669\u7684\u6210\u4eba\u60a3\u8005\u7684\u8f85\u52a9\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a<span>400mg\/d<\/span>\uff0c\u5747\u4e3a\u6bcf\u5929\u4e00\u6b21\u53e3\u670d\uff0c\u5b9c\u5728\u8fdb\u9910\u65f6\u670d\u836f\u3002\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u4f8b\u5982\uff1a\u4f53\u6db2\u6f74\u7559\u3001\u6076\u5fc3\u3001\u8179\u6cfb\u3001\u76ae\u75b9\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u3001\u8d2b\u8840\u3001\u75bc\u75db\u6027\u808c\u75c9\u631b\u4ee5\u53ca\u809d\u529f\u80fd\u635f\u4f24\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bc6\u5207\u5173\u6ce8\u809d\u529f\u80fd\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u540e\u82e5\u672a\u80fd\u83b7\u5f97\u6ee1\u610f\u7597\u6548\uff0c\u5982\u679c\u6ca1\u6709\u4e25\u91cd\u836f\u7269\u4e0d\u826f\u53cd\u5e94\uff0c\u5242\u91cf\u53ef\u589e\u52a0\u5230\u6bcf\u5929<span>0.6<\/span>\uff5e<span>0.8g<\/span>\uff1b\u82e5\u60a3\u8005\u4ece\u672c\u836f\u6301\u7eed\u83b7\u76ca\uff0c\u53ef\u6301\u7eed\u63a5\u53d7\u672c\u836f\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u6f5c\u5728\u53ef\u5207\u9664\u7684\u80c3\u80a0\u95f4\u8d28\u7624\u60a3\u8005\uff0c\u4f0a\u9a6c\u66ff\u5c3c\u65b0\u8f85\u52a9\u6cbb\u7597\u4e5f\u53ef\u4ee4\u60a3\u8005\u83b7\u76ca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u662f<span>CYP3A4<\/span>\u7684\u5e95\u7269\uff0c\u540c\u65f6\u7ed9\u4e88<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u540e\u4f0a\u9a6c\u66ff\u5c3c\u7684\u8840\u6d46\u6d53\u5ea6\u964d\u4f4e\uff0c\u4ece\u800c\u5bfc\u81f4\u7597\u6548\u51cf\u4f4e\uff0c\u5e94\u907f\u514d\u4f0a\u9a6c\u66ff\u5c3c\u4e0e<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u540c\u65f6\u670d\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u9a6c\u66ff\u5c3c\u5e94\u5728\u8fdb\u9910\u65f6\u670d\u7528\uff0c\u5e76\u996e\u4e00\u5927\u676f\u6c34\u3002\uff08<span>1<\/span>\uff09\u4f7f\u7528\u80f6\u56ca\u5242\u578b\u65f6\uff0c\u5bf9\u4e8e\u4e0d\u80fd\u541e\u54bd\u80f6\u56ca\u7684\u60a3\u8005\uff08\u5305\u62ec\u513f\u7ae5\uff09\uff0c\u53ef\u4ee5\u5c06\u80f6\u56ca\u5185\u836f\u7269\u5206\u6563\u4e8e\u6c34\u6216\u82f9\u679c\u6c41\u4e2d\u3002\u4f7f\u7528\u7247\u5242\u65f6\uff0c\u53ef\u4ee5\u5c06\u836f\u7247\u5206\u6563\u4e8e\u4e0d\u542b\u6c14\u4f53\u7684\u6c34\u6216\u82f9\u679c\u6c41\u4e2d\uff08<span>100mg<\/span>\u7247\u7ea6\u7528<span>50ml<\/span>\uff0c<span>400mg<\/span>\u7ea6\u7528<span>200ml<\/span>\uff09\u3002\u5e94\u6405\u62cc\u6df7\u60ac\u6db2\uff0c\u4e00\u65e6\u836f\u7247\u5d29\u89e3\u5b8c\u5168\u5e94\u7acb\u5373\u670d\u7528\u3002\uff08<span>2<\/span>\uff09\u5982\u679c\u63a5\u53d7\u4f0a\u9a6c\u66ff\u5c3c\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u51fa\u73b0\u4e25\u91cd\u975e\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94\uff08\u5982\u4e25\u91cd\u4f53\u6db2\u6f74\u7559\uff09\uff0c\u5e94\u505c\u836f\uff0c\u76f4\u5230\u4e0d\u826f\u53cd\u5e94\u6d88\u5931\uff0c\u7136\u540e\u518d\u6839\u636e\u8be5\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\u8c03\u6574\u5242\u91cf\u3002\uff08<span>3<\/span>\uff09\u5bf9\u4e8e<span>3<\/span>\u5c81\u4ee5\u4e0a\u513f\u7ae5\u4f7f\u7528\u4f0a\u9a6c\u66ff\u5c3c\u7684\u7814\u7a76\uff0c\u4e3b\u8981\u6765\u81ea\u56fd\u5916\u513f\u7ae5\u7814\u7a76\u6570\u636e\uff0c\u4e2d\u56fd\u513f\u7ae5\u4eba\u7fa4\u7528\u836f\u5b89\u5168\u6709\u6548\u6027\u6570\u636e\u6709\u9650\u3002\u5c1a\u65e0<span>3<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u7528\u836f\u7ecf\u9a8c\u3002\uff08<span>4<\/span>\uff09\u5df2\u6709\u62a5\u544a\u663e\u793a\u63a5\u53d7\u4f0a\u9a6c\u66ff\u5c3c\u6cbb\u7597\u7684\u513f\u7ae5\u548c\u9752\u6625\u524d\u671f\u9752\u5c11\u5e74\u51fa\u73b0\u53d1\u80b2\u8fdf\u7f13\u3002\u6682\u4e0d\u77e5\u4f0a\u9a6c\u66ff\u5c3c\u5ef6\u957f\u6cbb\u7597\u5bf9\u513f\u7ae5\u53d1\u80b2\u7684\u957f\u671f\u5f71\u54cd\u3002\u56e0\u6b64\uff0c\u5efa\u8bae\u5bf9\u4f7f\u7528\u4f0a\u9a6c\u66ff\u5c3c\u7684\u513f\u7ae5\u7684\u53d1\u80b2\u60c5\u51b5\u8fdb\u884c\u5bc6\u5207\u76d1\u6d4b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e94\u3001\u8212\u5c3c\u66ff\u5c3c<span> Sunitinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>12.5mg<\/span>\u3001<span>25mg<\/span>\u3001<span>37.5mg<\/span>\u3001<span>50mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u9a6c\u66ff\u5c3c\u6cbb\u7597\u5931\u8d25\u6216\u4e0d\u80fd\u8010\u53d7\u7684\u80c3\u80a0\u95f4\u8d28\u7624\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u53ef\u5207\u9664\u7684\u3001\u8f6c\u79fb\u6027\u9ad8\u5206\u5316\u8fdb\u5c55\u671f\u80f0\u817a\u795e\u7ecf\u5185\u5206\u6ccc\u7624\u6210\u5e74\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u80c3\u80a0\u95f4\u8d28\u7624\u7684\u6bcf\u5929\u63a8\u8350\u6700\u9ad8\u5242\u91cf\u4e3a<span>50mg<\/span>\uff0c\u670d\u836f<span>4<\/span>\u5468\u3001\u505c\u836f<span>2<\/span>\u5468\uff0c\u4e0e\u8fdb\u98df\u65e0\u76f8\u5173\u6027\uff1b\u82e5\u5fc5\u987b\u4e0e<span>CYP3A4<\/span>\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\uff0c\u5242\u91cf\u53ef\u51cf\u81f3<span>37.5mg<\/span>\uff1b\u82e5\u5fc5\u987b\u4e0e<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u8054\u5408\u4f7f\u7528\uff0c\u6700\u5927\u5242\u91cf\u4e0d\u8d85\u8fc7<span>87.5mg<\/span>\u3002\u5bf9\u4e8e\u80f0\u817a\u795e\u7ecf\u5185\u5206\u6ccc\u7624\uff0c\u63a8\u8350\u5242\u91cf\u4e3a<span>37.5mg<\/span>\uff0c\u53e3\u670d\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u8fde\u7eed\u670d\u836f\uff0c\u65e0\u505c\u836f\u671f\u3002\u4e0e\u98df\u7269\u540c\u670d\u6216\u4e0d\u540c\u670d\u5747\u53ef\u3002<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u4f8b\u5982\uff1a\u767d\u7ec6\u80de\u51cf\u5c11\u3001\u8179\u6cfb\u3001\u4e4f\u529b\u3001\u624b\u8db3\u7efc\u5408\u5f81\uff1b\u6f5c\u5728\u4e25\u91cd\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a\u809d\u6bd2\u6027\u3001\u5de6\u5fc3\u5ba4\u529f\u80fd\u969c\u788d\u3001<span>QTc<\/span>\u95f4\u671f\u5ef6\u957f\u3001\u51fa\u8840\u3001\u9ad8\u8840\u538b\u3001\u7532\u72b6\u817a\u529f\u80fd\u4e0d\u5168\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u82e5\u51fa\u73b0\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\u7684\u4e34\u5e8a\u8868\u73b0\uff0c\u5efa\u8bae\u505c\u836f\uff1b\u65e0\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\u4e34\u5e8a\u8bc1\u636e\u4f46\u5c04\u8840\u5206\u6570\uff1c<span>50%<\/span>\u4ee5\u53ca\u5c04\u8840\u5206\u6570\u4f4e\u4e8e\u57fa\u7ebf<span>20%<\/span>\u7684\u60a3\u8005\u4e5f\u5e94\u505c\u836f\u548c<span>\/<\/span>\u6216\u51cf\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53ef\u5ef6\u957f<span>QTc<\/span>\u95f4\u671f\uff0c\u4e14\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u3002\u5e94\u614e\u7528\u4e8e\u5df2\u77e5\u6709<span>QTc<\/span>\u95f4\u671f\u5ef6\u957f\u75c5\u53f2\u7684\u60a3\u8005\u3001\u670d\u7528\u6297\u5fc3\u5f8b\u5931\u5e38\u836f\u7269\u7684\u60a3\u8005\u6216\u6709\u76f8\u5e94\u57fa\u7840\u5fc3\u810f\u75be\u75c5\u3001\u5fc3\u52a8\u8fc7\u7f13\u548c\u7535\u89e3\u8d28\u7d0a\u4e71\u7684\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f7f\u7528\u671f\u95f4\u5982\u679c\u53d1\u751f\u4e25\u91cd\u9ad8\u8840\u538b\uff0c\u5e94\u6682\u505c\u4f7f\u7528\uff0c\u76f4\u81f3\u9ad8\u8840\u538b\u5f97\u5230\u63a7\u5236\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5177\u6709\u809d\u6bd2\u6027\uff0c\u53ef\u80fd\u5bfc\u81f4\u809d\u810f\u8870\u7aed\u6216\u6b7b\u4ea1\u3002\u5df2\u5728\u4e34\u5e8a\u7814\u7a76\u4e2d\u89c2\u5bdf\u5230\u809d\u810f\u8870\u7aed\u7684\u53d1\u751f\uff08\u53d1\u751f\u7387\uff1c<span>1%<\/span>\uff09\u3002\u5728\u6cbb\u7597\u5f00\u59cb\u524d\u3001\u6bcf\u4e2a\u6cbb\u7597\u5468\u671f\u3001\u4ee5\u53ca\u4e34\u5e8a\u9700\u8981\u65f6\u5e94\u76d1\u6d4b\u809d\u529f\u80fd\uff08<span>ALT<\/span>\uff0c<span>AST<\/span>\uff0c\u80c6\u7ea2\u7d20\uff09\u3002\u5f53\u51fa\u73b0<span>3<\/span>\u7ea7\u6216<span>4<\/span>\u7ea7\u836f\u7269\u76f8\u5173\u7684\u809d\u529f\u80fd\u4e0d\u826f\u53cd\u5e94\u5e94\u4e2d\u65ad\u7528\u836f\uff0c\u82e5\u65e0\u6cd5\u6062\u590d\u5e94\u7ec8\u6b62\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u516d\u3001\u963f\u4f10\u66ff\u5c3c <span>Avapritinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>100mg<\/span>\u3001<span>200mg<\/span>\u3001<span>300mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u643a\u5e26\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50\u53d7\u4f53<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:Symbol;\">a<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08<span>PDGFRA<\/span>\uff09\u5916\u663e\u5b50<span>18<\/span>\u7a81\u53d8\uff08\u5305\u62ec<span>PDGFRAD842V<\/span>\u7a81\u53d8\uff09\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u80c3\u80a0\u95f4\u8d28\u7624\u6210\u4eba\u60a3\u8005\u3002<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6bcf\u5929\u63a8\u8350\u53e3\u670d\u5242\u91cf\u4e3a<span>300mg<\/span>\uff0c\u81f3\u5c11\u5728\u9910\u524d<span>1<\/span>\u5c0f\u65f6\u548c\u9910\u540e<span>2<\/span>\u5c0f\u65f6\u7a7a\u8179\u7ed9\u836f\uff1b\u6301\u7eed\u6cbb\u7597\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u4e0e\u5f3a\u6548\u6216\u4e2d\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\u5408\u7528\uff1b\u5982\u679c\u65e0\u6cd5\u907f\u514d\u4e0e\u4e2d\u6548<span>CYP3A4<\/span>\u6291\u5236\u5242\u5408\u7528\uff0c\u8d77\u59cb\u5242\u91cf\u53ef\u964d\u4f4e\u81f3<span>100mg<\/span>\u6bcf\u5929\u4e00\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8be5\u9002\u5e94\u8bc1\u662f\u57fa\u4e8e\u4e00\u9879\u5305\u62ec<span>81<\/span>\u4f8b<span>PDGFRA<\/span>\u5916\u663e\u5b50<span>18<\/span>\u7a81\u53d8\u7684<span>NAVIGATOR<\/span>\u4e34\u5e8a\u7814\u7a76\u7684\u7ed3\u679c\u7ed9\u4e88\u7684\u9644\u6761\u4ef6\u6279\u51c6\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e74\u9f84\u2265<span>65<\/span>\u5c81\u60a3\u8005\u4e0d\u9700\u8c03\u6574\u5242\u91cf\uff1b<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u548c\u9752\u5c11\u5e74\u60a3\u8005\u614e\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u8f7b\u4e2d\u5ea6\u809d\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u4e0d\u5efa\u8bae\u8c03\u6574\u5242\u91cf\uff1b\u91cd\u5ea6\u809d\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u614e\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u6076\u5fc3\u3001\u75b2\u4e4f\u3001\u8d2b\u8840\u3001\u7736\u5468\u6c34\u80bf\u3001\u9762\u90e8\u6c34\u80bf\u3001\u9ad8\u80c6\u7ea2\u7d20\u8840\u75c7\u3001\u8179\u6cfb\u3001\u5455\u5410\u3001\u5916\u5468\u6c34\u80bf\u3001\u6d41\u6cea\u589e\u52a0\u3001\u98df\u6b32\u4e0b\u964d\u548c\u8bb0\u5fc6\u53d7\u635f\uff1b\u6700\u5e38\u89c1\u7684\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u4e3a\u8d2b\u8840\u548c\u80f8\u8154\u79ef\u6db2\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e03\u3001\u745e\u6d3e\u66ff\u5c3c<span> Ripretinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>50mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u63a5\u53d7\u8fc7<span>3<\/span>\u79cd\u6216\u4ee5\u4e0a\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08\u5305\u62ec\u4f0a\u9a6c\u66ff\u5c3c\uff09\u7684\u665a\u671f\u80c3\u80a0\u95f4\u8d28\u7624\u6210\u4eba\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6bcf\u5929\u63a8\u8350\u53e3\u670d\u5242\u91cf\u4e3a<span>150mg<\/span>\uff0c\u53ef\u4e0e\u98df\u7269\u540c\u670d\u6216\u7a7a\u8179\u7ed9\u836f\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u65e0\u6cd5\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u56e0\u4e0d\u826f\u53cd\u5e94\u9700\u964d\u4f4e\u5242\u91cf\uff0c\u63a8\u8350\u7684\u5242\u91cf\u4e3a<span>100mg<\/span>\u6bcf\u5929\u4e00\u6b21\uff1b\u5982\u60a3\u8005\u65e0\u6cd5\u8010\u53d7<span>100mg<\/span>\u6bcf\u5929\u4e00\u6b21\uff0c\u5219\u5e94\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8be5\u9002\u5e94\u8bc1\u662f\u57fa\u4e8e<span>4<\/span>\u7ebf\u80c3\u80a0\u95f4\u8d28\u7624<span>INVICTUS<\/span>\u7814\u7a76\u7ed3\u679c\u7ed9\u4e88\u7684\u9644\u6761\u4ef6\u6279\u51c6\uff1b\u8be5\u9002\u5e94\u8bc1\u7684\u5b8c\u5168\u6279\u51c6\u5c06\u53d6\u51b3\u4e8e\u6b63\u5728\u8fdb\u884c\u7684<span>ZL-2307-002<\/span>\u8bd5\u9a8c\u5728\u4e2d\u56fd\u60a3\u8005\u7684\u4e34\u5e8a\u83b7\u76ca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\uff1b\u5c1a\u672a\u5728\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u786e\u5b9a\u63a8\u8350\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5728\u513f\u7ae5\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5c1a\u4e0d\u660e\u786e\uff1b\u4e34\u5e8a\u7814\u7a76\u4e2d\u7eb3\u5165\u7684\u5e74\u9f84\u2265<span>65<\/span>\u5c81\u7684\u60a3\u8005\u6570\u5c1a\u4e0d\u8db3\u4ee5\u5145\u5206\u8bc1\u660e\u8001\u5e74\u60a3\u8005\u4e0e\u8f83\u5e74\u8f7b\u60a3\u8005\u4e4b\u95f4\u662f\u5426\u5b58\u5728\u836f\u7269\u5e94\u7b54\u5dee\u5f02\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u8131\u53d1\u3001\u75b2\u4e4f\u3001\u6076\u5fc3\u3001\u8179\u75db\u3001\u4fbf\u79d8\u3001\u808c\u75db\u3001\u8179\u6cfb\u3001\u98df\u6b32\u4e0b\u964d\u3001\u638c\u8dd6\u7ea2\u80bf\u7efc\u5408\u5f81\u548c\u5455\u5410\uff1b\u6700\u5e38\u89c1\u7684\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u4e3a\u8179\u75db\u3001\u8d2b\u8840\u3001\u6076\u5fc3\u548c\u5455\u5410\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u4e0e\u5f3a\u6548<span>CYP3A<\/span>\u8bf1\u5bfc\u5242\u3001\u6291\u5236\u5242\u5408\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u516b\u3001\u4f9d\u7ef4\u83ab\u53f8<span> Everolimus<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>2.5mg<\/span>\u3001<span>5mg<\/span>\u3001<span>10mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u53ef\u5207\u9664\u7684\u3001\u5c40\u90e8\u6669\u671f\u6216\u8f6c\u79fb\u6027\u7684\u3001\u5206\u5316\u826f\u597d\u7684\uff08\u4e2d\u5ea6\u6216\u9ad8\u5ea6\u5206\u5316\uff09\u8fdb\u5c55\u671f\u80f0\u817a\u795e\u7ecf\u5185\u5206\u6ccc\u7624\u6210\u4eba\u60a3\u8005\uff1b\u65e0\u6cd5\u624b\u672f\u5207\u9664\u7684\u3001\u5c40\u90e8\u6669\u671f\u6216\u8f6c\u79fb\u6027\u7684\u3001\u5206\u5316\u826f\u597d\u7684\u3001\u8fdb\u5c55\u671f\u975e\u529f\u80fd\u6027\u80c3\u80a0\u9053\u6216\u80ba\u6e90\u795e\u7ecf\u5185\u5206\u6ccc\u7624\u6210\u4eba\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u53e3\u8154\u708e\u3001\u76ae\u75b9\u3001\u75b2\u52b3\u3001\u8179\u6cfb\u3001\u611f\u67d3\u3001\u6076\u5fc3\u3001\u98df\u6b32\u4e0b\u964d\u3001\u8d2b\u8840\u3001\u5473\u89c9\u969c\u788d\u3001\u5468\u56f4\u6c34\u80bf\u3001\u9ad8\u8840\u7cd6\u548c\u5934\u75db\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u975e\u611f\u67d3\u6027\u80ba\u708e\u662f\u96f7\u5e15\u9709\u7d20\u884d\u751f\u7269\uff08\u5305\u62ec\u672c\u54c1\uff09\u7684\u7c7b\u6548\u5e94\u3002\u5bf9\u672c\u54c1\u6709\u6548\u6210\u5206\u3001\u5176\u4ed6\u96f7\u5e15\u9709\u7d20\u884d\u751f\u7269\u6216\u672c\u54c1\u4e2d\u4efb\u4f55\u8f85\u6599\u8fc7\u654f\u8005\u7981\u7528\u3002\u4f7f\u7528\u4f9d\u7ef4\u83ab\u53f8\u548c\u5176\u4ed6\u96f7\u5e15\u9709\u7d20\u884d\u751f\u7269\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u7684\u8fc7\u654f\u53cd\u5e94\u8868\u73b0\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\uff1a\u547c\u5438\u56f0\u96be\u3001\u6f6e\u7ea2\u3001\u80f8\u75db\u6216\u8840\u7ba1\u6027\u6c34\u80bf\uff08\u4f8b\u5982\uff1a\u4f34\u6216\u4e0d\u4f34\u547c\u5438\u529f\u80fd\u4e0d\u5168\u7684\u6c14\u9053\u6216\u820c\u80bf\u80c0\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u540c\u65f6\u4f7f\u7528\u8840\u7ba1\u7d27\u5f20\u7d20\u8f6c\u6362\u9176\u6291\u5236\u5242\u7684\u60a3\u8005\uff0c\u53ef\u80fd\u53d1\u751f\u8840\u7ba1\u6027\u6c34\u80bf\u7684\u98ce\u9669\u5347\u9ad8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u5e94\u907f\u514d\u63a5\u79cd\u6d3b\u75ab\u82d7\uff0c\u4f8b\u5982\u6d41\u611f\u3001\u9ebb\u75b9\u3001\u816e\u817a\u708e\u3001\u98ce\u75b9\u3001\u53e3\u670d\u810a\u9ad3\u7070\u8d28\u708e\u3001\u5361\u4ecb\u82d7\u3001\u9ec4\u70ed\u75c5\u3001\u6c34\u75d8\u548c<span>TY21a<\/span>\u4f24\u5bd2\u75ab\u82d7\u7b49\uff0c\u907f\u514d\u4e0e\u63a5\u79cd\u8fc7\u6d3b\u75ab\u82d7\u7684\u4eba\u5bc6\u5207\u63a5\u89e6\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u6240\u6709\u60a3\u8005\u90fd\u5e94\u8fdb\u884c\u5e38\u89c4\u7684\u4f9d\u7ef4\u83ab\u53f8\u5168\u8840\u8c37\u6d53\u5ea6\u76d1\u6d4b\u3002\u2265<span>65<\/span>\u5c81\u8001\u5e74\u60a3\u8005\u7528\u836f\u7684\u6b7b\u4ea1\u7387\u53ca\u53d1\u751f\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u800c\u7ec8\u6b62\u6cbb\u7597\u7684\u53d1\u751f\u7387\u660e\u663e\u589e\u9ad8\u3002\u56e0\u6b64\uff0c\u8001\u5e74\u60a3\u8005\u4f7f\u7528\u4f9d\u7ef4\u83ab\u53f8\uff0c\u5fc5\u987b\u76d1\u6d4b\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f\uff0c\u5e76\u53ca\u65f6\u8c03\u6574\u7528\u836f\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u907f\u514d\u5408\u5e76\u4f7f\u7528\u5f3a\u6548<span>CYP3A4<\/span>\u6216<span>P-<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\u3001<span>CYP3A4<\/span>\u5f3a\u6548\u8bf1\u5bfc\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e5d\u3001\u7d22\u51e1\u66ff\u5c3c <span>Surufatinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a<span>50mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e0\u6cd5\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u6669\u671f\u6216\u8f6c\u79fb\u6027\u3001\u8fdb\u5c55\u671f\u975e\u529f\u80fd\u6027\u3001\u5206\u5316\u826f\u597d\uff08<span>Gl<\/span>\u3001<span>G2<\/span>\uff09\u7684\u975e\u80f0\u817a\u6765\u6e90\u7684\u795e\u7ecf\u5185\u5206\u6ccc\u7624\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u4e8e<span>SANET-ep<\/span>\u7814\u7a76\uff0c\u63a8\u8350\u5242\u91cf\u4e3a<span>300mg<\/span><\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\/<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b21<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u8fde\u7eed\u670d\u836f\uff08\u6bcf<span>4<\/span>\u5468\u4e3a\u4e00\u4e2a\u6cbb\u7597\u5468\u671f\uff09\u3002\u53ef\u968f\u4f4e\u8102\u9910\uff08<span>500<\/span>\u5343\u5361\uff0c\u7ea6<span>20<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">%<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8102\u80aa\uff09<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u540c\u670d\u6216\u7a7a\u8179\u53e3\u670d\uff0c\u9700\u6574\u7c92\u541e\u670d\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u7528\u836f\u8fc7\u7a0b\u4e2d\u6839\u636e\u60a3\u8005\u4e2a\u4f53\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u8c03\u6574\u7528\u836f\uff0c\u5305\u62ec\u6682\u505c\u7528\u836f\u3001\u964d\u4f4e\u5242\u91cf\u6216\u6c38\u4e45\u505c\u7528\u672c\u54c1\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7528\u836f\u540e\uff0c\u5982<span>4<\/span>\u5468\u5185\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u81f3\u2264<span>1<\/span>\u7ea7\uff0c\u5efa\u8bae\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u8c03\u6574\u5242\u91cf\uff1a\u7b2c\u4e00\u6b21\u5242\u91cf\u8c03\u6574\u81f3\u6bcf\u5929<span>250mg<\/span>\uff1b\u7b2c\u4e8c\u6b21\u5242\u91cf\u8c03\u6574\u81f3\u6bcf\u5929<span>200mg<\/span>\uff1b\u82e5\u4ecd\u4e0d\u8010\u53d7\uff0c\u5219\u53ef\u8003\u8651<span>200mg<\/span>\u6bcf\u5929\u4e00\u6b21\u670d\u836f<span>3<\/span>\u5468\u505c\u836f<span>1<\/span>\u5468\u6216\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u5c1a\u65e0\u5bf9\u809d\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5f71\u54cd\u7684\u76f8\u5173\u6570\u636e\uff0c\u8f7b\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u8d77\u59cb\u5242\u91cf\uff0c\u4e2d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u987b\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u8f7b\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u987b\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\u5e76\u4e25\u5bc6\u76d1\u6d4b\u809d\u529f\u80fd\uff0c\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7981\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e25\u91cd\u6d3b\u52a8\u6027\u51fa\u8840\u3001\u6d3b\u52a8\u6027\u6d88\u5316\u9053\u6e83\u75a1\u3001\u672a\u6108\u5408\u7684\u80c3\u80a0\u7a7f\u5b54\u6216\u6d88\u5316\u9053\u7618\u60a3\u8005\u7981\u7528\u3002\u598a\u5a20\u3001\u54fa\u4e73\u671f\u5987\u5973\u7981\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u5c1a\u65e0\u672c\u54c1\u7528\u4e8e<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u6216\u9752\u5c11\u5e74\u60a3\u8005\u7684\u4e34\u5e8a\u6570\u636e\uff0c\u4e0d\u5efa\u8bae\u670d\u7528\u672c\u54c1\u3002\u5efa\u8bae\u8001\u5e74\u60a3\u8005\uff08<span>\u226565<\/span>\u5c81\uff09\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u65e0\u9700\u8c03\u6574\u8d77\u59cb\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u86cb\u767d\u5c3f\u3001\u9ad8\u8840\u538b\u3001\u8840\u80c6\u7ea2\u7d20\u5347\u9ad8\u3001\u8179\u6cfb\u3001\u8840\u767d\u86cb\u767d\u964d\u4f4e\u3001\u8840\u7518\u6cb9\u4e09\u916f\u5347\u9ad8\u3001<span>AST\/ALT<\/span>\u5347\u9ad8\u3001\u8840\u4fc3\u7532\u72b6\u817a\u6fc0\u7d20\u5347\u9ad8\u3001\u8179\u75db\u3001\u75b2\u4e4f<span>\/<\/span>\u4e4f\u529b\u3001\u8840\u5c3f\u9178\u5347\u9ad8\u3001\u51fa\u8840\u548c\u9aa8\u9abc\u808c\u8089\u75bc\u75db\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u907f\u514d\u6216\u614e\u91cd\u5408\u5e76\u4f7f\u7528<span>CYP3A4\/5<\/span>\u6291\u5236\u5242\u3001\u8bf1\u5bfc\u5242\u6216\u5e95\u7269\u3002<span style=\"color:red;\"><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u3001\u8d1d\u4f10\u73e0\u5355\u6297<span> Bevacizumab<\/span><\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>4ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408\u4ee5\u6c1f\u5c3f\u5627\u5576\u4e3a\u57fa\u7840\u7684\u5316\u7597\u9002\u7528\u4e8e\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u5168\u8eab\u7cfb\u7edf\u6027\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u4e00\u3001\u4e8c\u7ebf\u6cbb\u7597\uff0c\u53ef\u9009\u62e9\u8d1d\u4f10\u73e0\u5355\u6297<span>+<\/span>\u5316\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e00\u7ebf\u63a5\u53d7\u542b\u8d1d\u4f10\u73e0\u5355\u6297\u65b9\u6848\u6cbb\u7597\u75be\u75c5\u63a7\u5236\u540e\uff0c\u968f\u540e\u7ed9\u4e88\u8d1d\u4f10\u73e0\u5355\u6297<span>+<\/span>\u6c1f\u5c3f\u5627\u5576\u7c7b\u836f\u7269\u7ef4\u6301\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e00\u7ebf\u4f7f\u7528\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\u75be\u75c5\u8fdb\u5c55\u7684\u60a3\u8005\uff0c\u4e8c\u7ebf\u8f6c\u6362\u5316\u7597\u65b9\u6848\u540e\u53ef\u7ee7\u7eed\u8054\u7528\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\u76f4\u81f3\u75be\u75c5\u518d\u6b21\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u8d1d\u4f10\u73e0\u5355\u6297\u9759\u8109\u8f93\u6ce8\u7684\u63a8\u8350\u5242\u91cf\u4e3a\uff1a\u8054\u5408\u5316\u7597\u65b9\u6848\u65f6\uff0c<span>5mg\/kg<\/span>\u4f53\u91cd\uff0c\u6bcf\u4e24\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u6216<span>7.5mg\/kg<\/span>\u4f53\u91cd\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\u3002\u4e0d\u63a8\u8350\u964d\u4f4e\u8d1d\u4f10\u73e0\u5355\u6297\u7684\u4f7f\u7528\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u4e0e\u963f\u66ff\u5229\u73e0\u5355\u6297\u8054\u5408\u7528\u836f\u6cbb\u7597\u809d\u7ec6\u80de\u764c\u57fa\u4e8e<span>IMbrave150<\/span>\u7814\u7a76\uff1a\u63a8\u8350\u5242\u91cf\u4e3a<span>15mg\/kg<\/span>\u9759\u8109\u6ce8\u5c04\uff0c\u5728\u540c\u4e00\u5929\u9759\u8109\u6ce8\u5c04\u963f\u66ff\u5229\u73e0\u5355\u6297<span>1200mg<\/span>\u7ed9\u836f\u540e\u8fdb\u884c\uff0c\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297\u7a00\u91ca\u540e\u91c7\u7528\u9759\u8109\u8f93\u6ce8\u7684\u65b9\u5f0f\u7ed9\u836f\uff0c\u9996\u6b21\u9759\u8109\u8f93\u6ce8\u65f6\u95f4\u9700\u6301\u7eed<span>90<\/span>\u5206\u949f\u3002\u5982\u679c\u7b2c\u4e00\u6b21\u8f93\u6ce8\u8010\u53d7\u6027\u826f\u597d\uff0c\u5219\u7b2c\u4e8c\u6b21\u8f93\u6ce8\u7684\u65f6\u95f4\u53ef\u4ee5\u7f29\u77ed\u5230<span>60<\/span>\u5206\u949f\u3002\u5982\u679c\u60a3\u8005\u5bf9<span>60<\/span>\u5206\u949f\u7684\u8f93\u6ce8\u4e5f\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u90a3\u4e48\u968f\u540e\u8fdb\u884c\u7684\u6240\u6709\u8f93\u6ce8\u90fd\u53ef\u4ee5\u7528<span>30<\/span>\u5206\u949f\u7684\u65f6\u95f4\u5b8c\u6210\u3002\u8d1d\u4f10\u73e0\u5355\u6297\u4e0d\u80fd\u91c7\u7528\u9759\u8109\u5185\u63a8\u6ce8\u6216\u5feb\u901f\u6ce8\u5c04\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u8001\u5e74\u60a3\u8005\u4e2d\u5e94\u7528\u65f6\u4e0d\u9700\u8981\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51fa\u73b0\u4ee5\u4e0b\u60c5\u51b5\uff0c\u505c\u6b62\u4f7f\u7528\u8d1d\u4f10\u73e0\u5355\u6297\uff1a\u80c3\u80a0\u9053\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff08\u80c3\u80a0\u9053\u7a7f\u5b54\u3001\u80c3\u80a0\u9053\u7618\u5f62\u6210\u3001\u8179\u8154\u8113\u80bf\uff09\uff0c\u6d89\u53ca\u5230\u5185\u810f\u7618\u5f62\u6210\uff1b\u4e25\u91cd\u51fa\u8840\uff08\u4f8b\u5982\u9700\u8981\u5e72\u9884\u6cbb\u7597\uff09\uff1b\u4e25\u91cd\u52a8\u8109\u8840\u6813\u4e8b\u4ef6\uff1b\u9ad8\u8840\u538b\u5371\u8c61\u6216\u9ad8\u8840\u538b\u8111\u75c5\uff1b\u53ef\u9006\u6027\u540e\u90e8\u767d\u8d28\u8111\u75c5\u7efc\u5408\u5f81\uff1b\u80be\u75c5\u7efc\u5408\u5f81\uff1b\u5371\u53ca\u751f\u547d\uff08<span>4<\/span>\u7ea7\uff09\u7684\u9759\u8109\u8840\u6813\u6813\u585e\u4e8b\u4ef6\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u51fa\u73b0\u4ee5\u4e0b\u72b6\u51b5\uff0c\u9700\u6682\u505c\u4f7f\u7528\u8d1d\u4f10\u73e0\u5355\u6297\uff1a\u62e9\u671f\u624b\u672f\u524d<span>4<\/span>\u5468\uff1b\u836f\u7269\u63a7\u5236\u4e0d\u826f\u7684\u4e25\u91cd\u9ad8\u8840\u538b\uff1b\u4e2d\u5ea6\u5230\u91cd\u5ea6\u7684\u86cb\u767d\u5c3f\u9700\u8981\u8fdb\u4e00\u6b65\u8bc4\u4f30\uff1b\u4e25\u91cd\u8f93\u6db2\u53cd\u5e94\uff1b\u9700\u8981\u5e72\u9884\u6cbb\u7597\u7684\u4f24\u53e3\u88c2\u5f00\u4ee5\u53ca\u4f24\u53e3\u6108\u5408\u5e76\u53d1\u75c7\uff08\u6682\u505c\u7528\u836f\u81f3\u4f24\u53e3\u5b8c\u5168\u6108\u5408\uff09\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u80fd\u5c06\u8d1d\u4f10\u73e0\u5355\u6297\u8f93\u6ce8\u6db2\u4e0e\u53f3\u65cb\u7cd6\u6216\u8461\u8404\u7cd6\u6eb6\u6db2\u540c\u65f6\u6216\u6df7\u5408\u7ed9\u836f\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297\u914d\u5236\uff0c\u7528<span>0.9%<\/span>\u7684\u6c2f\u5316\u94a0\u6eb6\u6db2\u7a00\u91ca\u5230\u9700\u8981\u7684\u7ed9\u836f\u5bb9\u79ef\u3002\u8d1d\u4f10\u73e0\u5355\u6297\u6eb6\u6db2\u7684\u7ec8\u6d53\u5ea6\u5e94\u8be5\u4fdd\u6301\u5728<span>1.4<\/span>\uff5e<span>16.5mg\/ml<\/span>\u4e4b\u95f4\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">12.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297\u7981\u6b62\u51b7\u51bb\u50a8\u5b58\uff0c\u7981\u6b62\u6447\u52a8\u3002\u5e94\u907f\u5149\uff0c<span>2<\/span>\uff5e<span>8<\/span>\u2103\u5728\u539f\u5305\u88c5\u4e2d\u50a8\u5b58\u548c\u8fd0\u8f93\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">13.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728<span>2<\/span>\uff5e<span>30<\/span>\u2103\u6761\u4ef6\u4e0b\uff0c<span>0.9%<\/span>\u7684\u6c2f\u5316\u94a0\u6eb6\u6db2\u4e2d\uff0c\u8d1d\u4f10\u73e0\u5355\u6297\u5728\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u7684\u5316\u5b66\u548c\u7269\u7406\u7a33\u5b9a\u6027\u53ef\u4ee5\u4fdd\u6301<span>48<\/span>\u4e2a\u5c0f\u65f6\u3002\u4ea7\u54c1\u5728\u65e0\u83cc\u6761\u4ef6\u4e0b\u914d\u5236\u540e\u5728<span>2<\/span>\uff5e<span>8<\/span>\u2103\u6761\u4ef6\u4e0b\u7684\u50a8\u5b58\u65f6\u95f4\u4e0d\u5b9c\u8d85\u8fc7<span>24<\/span>\u5c0f\u65f6\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e00\u3001\u897f\u59a5\u6614\u5355\u6297<span> Cetuximab<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>20ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u6cbb\u7597<span>RAS<\/span>\u3001<span>BRAF<\/span>\u57fa\u56e0\u91ce\u751f\u578b\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff1a\u4e0e<span>FOLFOX<\/span>\u6216<span>FOLFIRI<\/span>\u65b9\u6848\u8054\u5408\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\uff1b\u4e0e\u4f0a\u7acb\u66ff\u5eb7\u8054\u5408\u7528\u4e8e\u7ecf\u542b\u4f0a\u7acb\u66ff\u5eb7\u6cbb\u7597\u5931\u8d25\u540e\u7684\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u4f7f\u7528\u7ecf\u8fc7\u9a8c\u8bc1\u7684\u65b9\u6cd5\u68c0\u6d4b<span>RAS<\/span>\u57fa\u56e0\u72b6\u6001\uff0c<span>RAS<\/span>\u57fa\u56e0\u91ce\u751f\u578b\u662f\u63a5\u53d7\u897f\u59a5\u6614\u5355\u6297\u6cbb\u7597\u7684\u5148\u51b3\u6761\u4ef6\uff0c\u672c\u54c1\u4e0d\u7528\u4e8e\u6cbb\u7597<span>RAS<\/span>\u57fa\u56e0\u7a81\u53d8\u578b\u6216<span>RAS<\/span>\u72b6\u6001\u4e0d\u660e\u7684\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f6c\u5316\u6027\u6cbb\u7597\uff1a\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u5408\u5e76\u809d\u8f6c\u79fb\u548c<span>\/<\/span>\u6216\u80ba\u8f6c\u79fb\uff0c\u6f5c\u5728\u53ef\u5207\u9664\uff0c\u53ef\u9009\u62e9\u897f\u59a5\u6614\u5355\u6297\u8054\u5408\u5316\u7597\uff08<span>RAS<\/span>\u91ce\u751f\u578b\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u59d1\u606f\u6cbb\u7597\uff1a\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff08<span>RAS<\/span>\u91ce\u751f\u578b\uff09\u4e00\u3001\u4e8c\u7ebf\u6cbb\u7597\uff0c\u5c24\u5176\u662f\u5de6\u534a\u80a0\u764c\u60a3\u8005\uff0c\u53ef\u9009\u62e9\u897f\u59a5\u6614\u5355\u6297<span>+<\/span>\u5316\u7597\u3002\u5bf9\u4e00\u3001\u4e8c\u7ebf\u6cbb\u7597\u4e2d\u6ca1\u6709\u4f7f\u7528\u897f\u59a5\u6614\u5355\u6297\u7684\u60a3\u8005\uff08<span>RAS<\/span>\u91ce\u751f\u578b\uff09\uff0c\u53ef\u9009\u62e9\u897f\u59a5\u6614\u5355\u6297\u8054\u5408\u4f0a\u7acb\u66ff\u5eb7\u5316\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u521d\u59cb\u4f7f\u7528\u897f\u59a5\u6614\u5355\u6297\u6cbb\u7597\u6709\u6548\uff08<span>CR\/PR\/SD<\/span>\uff09\uff0c\u8fdb\u5c55\u540e\u63a5\u53d7\u4e0d\u542b\u897f\u59a5\u6614\u5355\u6297\u7684\u4e8c\u7ebf\u6216\u540e\u7ebf\u6cbb\u7597\u5e76\u518d\u6b21\u53d1\u751f\u8fdb\u5c55\u65f6\uff0c\u5982<span>RAS<\/span>\u57fa\u56e0\u4ecd\u4e3a\u91ce\u751f\u578b\uff0c\u53ef\u8003\u8651\u897f\u59a5\u6614\u5355\u6297\u8054\u5408\u4f0a\u7acb\u66ff\u5eb7\u8fdb\u884c\u518d\u6311\u6218\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5e38\u53ef\u5f15\u8d77\u4e0d\u540c\u7a0b\u5ea6\u7684\u76ae\u80a4\u6bd2\u6027\u53cd\u5e94\uff0c\u4e3b\u8981\u8868\u73b0\u4e3a\u75e4\u75ae\u6837\u76ae\u75b9\uff0c\u6b64\u7c7b\u60a3\u8005\u7528\u836f\u671f\u95f4\u5e94\u6ce8\u610f\u907f\u5149\u3002\u8f7b\u4e2d\u5ea6\u76ae\u80a4\u6bd2\u6027\u53cd\u5e94\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u53d1\u751f\u91cd\u5ea6\u76ae\u80a4\u6bd2\u6027\u53cd\u5e94\u8005\uff0c\u5e94\u914c\u60c5\u51cf\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e25\u91cd\u7684\u8f93\u6db2\u53cd\u5e94\u53d1\u751f\u7387\u4e3a<span>3%<\/span>\uff0c\u81f4\u6b7b\u7387\u4f4e\u4e8e<span>0.1%<\/span>\u3002\u5176\u4e2d<span>90%<\/span>\u53d1\u751f\u4e8e\u7b2c\u4e00\u6b21\u4f7f\u7528\u65f6\uff0c\u4ee5\u7a81\u53d1\u6027\u6c14\u9053\u6897\u963b\u3001\u8368\u9ebb\u75b9\u548c\u4f4e\u8840\u538b\u4e3a\u7279\u5f81\u3002\u9996\u6b21\u6ef4\u6ce8\u672c\u54c1\u4e4b\u524d\uff0c\u60a3\u8005\u5fc5\u987b\u63a5\u53d7\u6297\u7ec4\u80fa\u836f\u7269\u548c\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7c7b\u836f\u7269\u7684\u6cbb\u7597\uff0c\u5efa\u8bae\u5728\u968f\u540e\u6bcf\u6b21\u4f7f\u7528\u672c\u54c1\u4e4b\u524d\u90fd\u5bf9\u60a3\u8005\u8fdb\u884c\u8fd9\u79cd\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4ec5\u5bf9\u809d\u80be\u529f\u80fd\u6b63\u5e38\u7684\u60a3\u8005\uff08\u8840\u6e05\u808c\u9150\u2264\u6b63\u5e38\u503c\u4e0a\u9650\u7684<span>1.5<\/span>\u500d\uff0c\u8f6c\u6c28\u9176\u2264\u6b63\u5e38\u503c\u4e0a\u9650\u7684<span>5<\/span>\u500d\uff0c\u80c6\u7ea2\u7d20\u2264\u6b63\u5e38\u503c\u4e0a\u9650\u7684<span>1.5<\/span>\u500d\uff09\u8fdb\u884c\u8fc7\u672c\u54c1\u7684\u76f8\u5173\u7814\u7a76\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5e94\u50a8\u5b58\u5728<span>2<\/span>\uff5e<span>8<\/span>\u2103\uff0c\u7981\u6b62\u51b7\u51bb\uff0c\u5f00\u542f\u540e\u5e94\u7acb\u5373\u4f7f\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e8c\u3001\u544b\u55b9\u66ff\u5c3c<span> Fruquintinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u786c\u80f6\u56ca\u5242\uff1a<span>1mg<\/span>\u3001<span>5mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\uff1a\u672c\u54c1\u5355\u836f\u9002\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u6c1f\u5c3f\u5627\u5576\u7c7b\u3001\u5965\u6c99\u5229\u94c2\u548c\u4f0a\u7acb\u66ff\u5eb7\u4e3a\u57fa\u7840\u7684\u5316\u7597\uff0c\u4ee5\u53ca\u65e2\u5f80\u63a5\u53d7\u8fc7\u6216\u4e0d\u9002\u5408\u63a5\u53d7<span>VEGF<\/span>\u6cbb\u7597\u3001<span>EGFR<\/span>\u6cbb\u7597\uff08<span>RAS<\/span>\u91ce\u751f\u578b\uff09\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08<span>mCRC<\/span>\uff09\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u65e0\u9700\u8fdb\u884c\u57fa\u56e0\u68c0\u6d4b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a<span>5mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e00\u6b21\uff1b\u8fde\u7eed\u670d\u836f<span>3<\/span>\u5468\uff0c\u968f\u540e\u505c\u836f<span>1<\/span>\u5468\uff08\u6bcf<span>4<\/span>\u5468\u4e3a\u4e00\u4e2a\u6cbb\u7597\u5468\u671f\uff09\u3002\u6301\u7eed\u6309\u6cbb\u7597\u5468\u671f\u670d\u836f\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u544b\u55b9\u66ff\u5c3c\u53ef\u4e0e\u98df\u7269\u540c\u670d\u6216\u7a7a\u8179\u53e3\u670d\uff0c\u9700\u6574\u7c92\u541e\u670d\u3002\u5efa\u8bae\u6bcf\u5929\u540c\u4e00\u65f6\u6bb5\u670d\u836f\uff0c\u5982\u679c\u670d\u836f\u540e\u60a3\u8005\u5455\u5410\uff0c\u65e0\u9700\u8865\u670d\uff1b\u6f0f\u670d\u5242\u91cf\uff0c\u4e0d\u5e94\u5728\u6b21\u65e5\u52a0\u670d\uff0c\u5e94\u6309\u5e38\u89c4\u670d\u7528\u4e0b\u4e00\u6b21\u5904\u65b9\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e2d\u56fd\u4eba\u7fa4\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u53d1\u751f\u7387\u2265<span>20%<\/span>\uff09\u4e3a\u9ad8\u8840\u538b\u3001\u86cb\u767d\u5c3f\u3001\u624b\u8db3\u76ae\u80a4\u53cd\u5e94\u3001\u53d1\u58f0\u56f0\u96be\u3001\u51fa\u8840\u3001\u8f6c\u6c28\u9176\u5347\u9ad8\u3001\u7532\u72b6\u817a\u529f\u80fd\u68c0\u67e5\u5f02\u5e38\u3001\u8179\u75db<span>\/<\/span>\u8179\u90e8\u4e0d\u9002\u3001\u53e3\u8154\u9ecf\u819c\u708e\u3001\u75b2\u4e4f<span>\/<\/span>\u4e4f\u529b\u3001\u8179\u6cfb\u3001\u611f\u67d3\u3001\u8840\u80c6\u7ea2\u7d20\u5347\u9ad8\u4ee5\u53ca\u98df\u6b32\u4e0b\u964d\u3002\u76ee\u524d\u5c1a\u672a\u6709\u836f\u7269\u6027\u809d\u529f\u80fd\u635f\u4f24\u7684\u62a5\u544a\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e25\u91cd\u6d3b\u52a8\u6027\u51fa\u8840\u3001\u6d3b\u52a8\u6027\u6d88\u5316\u6027\u6e83\u75a1\u3001\u672a\u6108\u5408\u7684\u80c3\u80a0\u7a7f\u5b54\u3001\u6d88\u5316\u9053\u7618\u60a3\u8005\u7981\u7528\u3002\u91cd\u5ea6\u809d\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7981\u7528\u3002\u598a\u5a20\u3001\u54fa\u4e73\u671f\u5987\u5973\u7981\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5bf9\u672c\u54c1\u4efb\u4f55\u6210\u5206\u8fc7\u654f\u8005\u7981\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u5c1a\u65e0\u672c\u54c1\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u7684\u4e34\u5e8a\u8d44\u6599\u3002<span><\/span><\/span>\n<\/p>\n<p><b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><br \/>\n<\/span><\/b> <\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8840\u6db2\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e00\u3001\u4f0a\u9a6c\u66ff\u5c3c<span> Imatinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08<span>1<\/span>\uff09\u7247\u5242\uff1a<span>100mg<\/span>\u3001<span>400mg<\/span>\uff1b\uff08<span>2<\/span>\uff09\u80f6\u56ca\uff1a<span>50mg<\/span>\u3001<span>100mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u6cbb\u7597\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u7684\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08<span>Ph+CML<\/span>\uff09\u7684\u6162\u6027\u671f\u3001\u52a0\u901f\u671f\u6216\u6025\u53d8\u671f\uff1b\u8054\u5408\u5316\u7597\u6cbb\u7597\u65b0\u8bca\u65ad\u7684\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u7684\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08<span>Ph+ALL<\/span>\uff09\u7684\u513f\u7ae5\u60a3\u8005\uff1b\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u7684\u6216\u96be\u6cbb\u7684\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u7684\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08<span>Ph+ALL<\/span>\uff09\u7684\u6210\u4eba\u60a3\u8005\uff1b\u7528\u4e8e\u6cbb\u7597\u55dc\u9178\u7c92\u7ec6\u80de\u589e\u591a\u7efc\u5408\u5f81\uff08<span>HES<\/span>\uff09\u548c<span>\/<\/span>\u6216\u6162\u6027\u55dc\u9178\u7c92\u7ec6\u80de\u767d\u8840\u75c5\uff08<span>CEL<\/span>\uff09\u4f34\u6709<span>FIP1L1-PDGFR<\/span>\u03b1\u878d\u5408\u57fa\u56e0\u7684\u6210\u5e74\u60a3\u8005\uff1b\u7528\u4e8e\u6cbb\u7597\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81<span>\/<\/span>\u9aa8\u9ad3\u589e\u6b96\u6027\u75be\u75c5\uff08<span>MDS\/MPD<\/span>\uff09\u4f34\u6709\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08<span>PDGFR<\/span>\uff09\u57fa\u56e0\u91cd\u6392\u7684\u6210\u5e74\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u8bca\u65ad\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u6216<span>BCR-ABL<\/span>\u9633\u6027\u7684\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u6216\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff0c\u6216\u4f34\u6709<span>PDGFR<\/span>\u57fa\u56e0\u91cd\u6392\u7684\u9ad3\u7cfb\u589e\u6b96\u6027\u80bf\u7624\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u5f53\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\u8bc4\u4f30\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u8840\u6db2\u5b66\u3001\u7ec6\u80de\u9057\u4f20\u5b66\u548c\u5206\u5b50\u751f\u7269\u5b66\u53cd\u5e94\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e0d\u540c\u75be\u75c5\u79cd\u7c7b\u548c\u5206\u671f\uff0c\u9009\u62e9\u521d\u59cb\u6cbb\u7597\u5242\u91cf\uff0c\u6cbb\u7597\u4e2d\u6839\u636e\u7597\u6548\u548c\u4e0d\u826f\u53cd\u5e94\u8c03\u6574\u5242\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e38\u89c1\u4e0d\u826f\u4e8b\u4ef6\uff08\uff1e<span>10%<\/span>\uff09\u4e3a\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u3001\u8d2b\u8840\u3001\u5934\u75db\u3001\u6d88\u5316\u4e0d\u826f\u3001\u6c34\u80bf\u3001\u4f53\u91cd\u589e\u52a0\u3001\u6076\u5fc3\u3001\u5455\u5410\u3001\u808c\u8089\u75c9\u631b\u3001\u808c\u8089\u9aa8\u9abc\u75db\u3001\u8179\u6cfb\u3001\u76ae\u75b9\u3001\u75b2\u52b3\u548c\u8179\u75db\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u671f\u95f4\u56e0\u6bd2\u6027\u4e0d\u53ef\u8010\u53d7\u6216\u8010\u836f\u65f6\uff0c\u53ef\u9009\u62e9\u4e8c\u4ee3\u836f\u7269\u66ff\u6362\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u9a6c\u66ff\u5c3c\u7528\u4e8e\u6210\u4eba\u521d\u6cbb\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u7684\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08\u5168\u7403\u5176\u4ed6\u56fd\u5bb6\u5df2\u6279\u51c6\u7684\u9002\u5e94\u8bc1\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u662f<span>CYP3A4<\/span>\u7684\u5e95\u7269\uff0c\u540c\u65f6\u7ed9\u4e88<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u540e\u4f0a\u9a6c\u66ff\u5c3c\u7684\u8840\u6d46\u6d53\u5ea6\u964d\u4f4e\uff0c\u4ece\u800c\u5bfc\u81f4\u7597\u6548\u51cf\u4f4e\uff0c\u5e94\u907f\u514d\u4f0a\u9a6c\u66ff\u5c3c\u4e0e<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u540c\u65f6\u670d\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u9a6c\u66ff\u5c3c\u5e94\u5728\u8fdb\u9910\u65f6\u670d\u7528\uff0c\u5e76\u996e\u4e00\u5927\u676f\u6c34\u3002\uff08<span>1<\/span>\uff09\u4f7f\u7528\u80f6\u56ca\u5242\u578b\u65f6\uff0c\u5bf9\u4e8e\u4e0d\u80fd\u541e\u54bd\u80f6\u56ca\u7684\u60a3\u8005\uff08\u5305\u62ec\u513f\u7ae5\uff09\uff0c\u53ef\u4ee5\u5c06\u80f6\u56ca\u5185\u836f\u7269\u5206\u6563\u4e8e\u6c34\u6216\u82f9\u679c\u6c41\u4e2d\u3002\u4f7f\u7528\u7247\u5242\u65f6\uff0c\u53ef\u4ee5\u5c06\u836f\u7247\u5206\u6563\u4e8e\u4e0d\u542b\u6c14\u4f53\u7684\u6c34\u6216\u82f9\u679c\u6c41\u4e2d\uff08<span>100mg<\/span>\u7247\u7ea6\u7528<span>50ml<\/span>\uff0c<span>400mg<\/span>\u7ea6\u7528<span>200ml<\/span>\uff09\u3002\u5e94\u6405\u62cc\u6df7\u60ac\u6db2\uff0c\u4e00\u65e6\u836f\u7247\u5d29\u89e3\u5b8c\u5168\u5e94\u7acb\u5373\u670d\u7528\u3002\uff08<span>2<\/span>\uff09\u5982\u679c\u63a5\u53d7\u4f0a\u9a6c\u66ff\u5c3c\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u51fa\u73b0\u4e25\u91cd\u975e\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94\uff08\u5982\u4e25\u91cd\u4f53\u6db2\u6f74\u7559\uff09\uff0c\u5e94\u505c\u836f\uff0c\u76f4\u5230\u4e0d\u826f\u53cd\u5e94\u6d88\u5931\uff0c\u7136\u540e\u518d\u6839\u636e\u8be5\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\u8c03\u6574\u5242\u91cf\u3002\uff08<span>3<\/span>\uff09\u5bf9\u4e8e<span>3<\/span>\u5c81\u4ee5\u4e0a\u513f\u7ae5\u4f7f\u7528\u4f0a\u9a6c\u66ff\u5c3c\u7684\u7814\u7a76\uff0c\u4e3b\u8981\u6765\u81ea\u56fd\u5916\u513f\u7ae5\u7814\u7a76\u6570\u636e\uff0c\u4e2d\u56fd\u513f\u7ae5\u4eba\u7fa4\u7528\u836f\u5b89\u5168\u6709\u6548\u6027\u6570\u636e\u6709\u9650\u3002\u5c1a\u65e0<span>3<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u7528\u836f\u7ecf\u9a8c\u3002\uff08<span>4<\/span>\uff09\u5df2\u6709\u62a5\u544a\u663e\u793a\u63a5\u53d7\u4f0a\u9a6c\u66ff\u5c3c\u6cbb\u7597\u7684\u513f\u7ae5\u548c\u9752\u6625\u524d\u671f\u9752\u5c11\u5e74\u51fa\u73b0\u53d1\u80b2\u8fdf\u7f13\u3002\u6682\u4e0d\u77e5\u4f0a\u9a6c\u66ff\u5c3c\u5ef6\u957f\u6cbb\u7597\u5bf9\u513f\u7ae5\u53d1\u80b2\u7684\u957f\u671f\u5f71\u54cd\u3002\u56e0\u6b64\uff0c\u5efa\u8bae\u5bf9\u4f7f\u7528\u4f0a\u9a6c\u66ff\u5c3c\u7684\u513f\u7ae5\u7684\u53d1\u80b2\u60c5\u51b5\u8fdb\u884c\u5bc6\u5207\u76d1\u6d4b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u8fbe\u6c99\u66ff\u5c3c<span> Dasatinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>20mg<\/span>\u3001<span>50mg<\/span>\u3001<span>70mg<\/span>\u3001<span>100mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4f0a\u9a6c\u66ff\u5c3c\u8010\u836f\uff0c\u6216\u4e0d\u8010\u53d7\u7684\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u6162\u6027\u671f\u3001\u52a0\u901f\u671f\u548c\u6025\u53d8\u671f\uff08\u6025\u7c92\u53d8\u548c\u6025\u6dcb\u53d8\uff09\u6210\u5e74\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u8bca\u65ad\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u6216<span>BCR-ABL<\/span>\u9633\u6027\u7684\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u6216\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u8be5\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\uff08\u5305\u62ec<span>BCR-ABL<\/span>\u7a81\u53d8\uff09\u8bc4\u4f30\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u8840\u6db2\u5b66\u3001\u7ec6\u80de\u9057\u4f20\u5b66\u548c\u5206\u5b50\u5b66\u53cd\u5e94\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e0d\u540c\u75be\u75c5\u79cd\u7c7b\u548c\u5206\u671f\uff0c\u9009\u62e9\u521d\u59cb\u6cbb\u7597\u5242\u91cf\uff0c\u6cbb\u7597\u4e2d\u6839\u636e\u7597\u6548\u548c\u4e0d\u826f\u53cd\u5e94\u8c03\u6574\u5242\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e38\u89c1\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u3001\u8d2b\u8840\u3001\u80f8\u8154\u79ef\u6db2\u3001\u5934\u75db\u3001\u8179\u6cfb\u3001\u75b2\u52b3\u7b49\uff0c\u5c11\u6570\u6709\u80ba\u52a8\u8109\u9ad8\u538b\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u662f<span>CYP3A4<\/span>\u7684\u5e95\u7269\uff0c\u4e0d\u63a8\u8350\u8054\u5408\u5f3a\u6548\u7684<span>CYP3A4<\/span>\u6291\u5236\u5242\u3002\u5982\u679c\u65e0\u6cd5\u907f\u514d\u5408\u5e76\u7528\u836f\uff0c\u5219\u5e94\u5bf9\u6bd2\u6027\u53cd\u5e94\u8fdb\u884c\u5bc6\u5207\u76d1\u6d4b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fbe\u6c99\u66ff\u5c3c\u7528\u4e8e\u6210\u4eba\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u7684\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08<span>FDA<\/span>\u5df2\u6279\u51c6\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e09\u3001\u5c3c\u6d1b\u66ff\u5c3c<span> Nilotinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>150mg<\/span>\u3001<span>200mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65b0\u8bca\u65ad\u7684\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u7684\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u6162\u6027\u671f\u6210\u4eba\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u65e2\u5f80\u6cbb\u7597\uff08\u5305\u62ec\u4f0a\u9a6c\u66ff\u5c3c\uff09\u8010\u836f\u6216\u4e0d\u8010\u53d7\u7684\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u7684<span>Ph+CML<\/span>\u6162\u6027\u671f\u6216\u52a0\u901f\u671f\u6210\u4eba\u60a3\u8005\u3002<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c3c\u6d1b\u66ff\u5c3c\u4e0d\u53ef\u7528\u4e8e\u4f4e\u8840\u94be\u3001\u4f4e\u8840\u9541\u6216\u957f<span>QT<\/span>\u7efc\u5408\u5f81\u7684\u60a3\u8005\u3002\u5728\u4f7f\u7528\u5c3c\u6d1b\u66ff\u5c3c\u4ee5\u524d\u5fc5\u987b\u7ea0\u6b63\u4f4e\u94be\u548c\u4f4e\u9541\uff0c\u5e76\u5b9a\u671f\u8fdb\u884c\u76d1\u6d4b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e38\u89c1\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u3001\u8d2b\u8840\u3001\u98df\u6b32\u51cf\u9000\u3001\u76ae\u75b9\u3001\u808c\u8089\u5173\u8282\u75db\u7b49\u3002<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u8054\u5408\u53ef\u5ef6\u957f<span>QTc<\/span>\u95f4\u671f\u7684\u836f\u7269\u548c<span>CYP3A4<\/span>\u7684\u5f3a\u6548\u6291\u5236\u5242\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u809d\u529f\u80fd\u635f\u4f24\u7684\u60a3\u8005\u5efa\u8bae\u51cf\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u5f00\u59cb\u7ed9\u836f\u524d\u3001\u7ed9\u836f\u8fc7\u7a0b\u4e2d\u3001\u7ed9\u836f\u540e\u5747\u5e94\u5b9a\u671f\u8fdb\u884c\u5fc3\u7535\u56fe\u68c0\u67e5\u4ee5\u76d1\u6d4b<span>QTc<\/span>\uff0c\u5e76\u4e14\u5728\u4efb\u4f55\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u65f6\u4e5f\u5e94\u5982\u6b64\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56db\u3001\u5409\u745e\u66ff\u5c3c<span> Gilteritinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>40mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u7528\u4e8e\u6cbb\u7597\u91c7\u7528\u7ecf\u5145\u5206\u9a8c\u8bc1\u7684\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230\u643a\u5e26<span>FMS<\/span>\u6837\u916a\u6c28\u9178\u6fc0\u9176<span>3<\/span>\uff08<span>FLT3<\/span>\uff09\u7a81\u53d8\u7684\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08<span>AML<\/span>\uff09\u6210\u4eba\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u4f7f\u7528\u5bcc\u9a6c\u9178\u5409\u745e\u66ff\u5c3c\u7247\u4e4b\u524d\uff0c\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027<span>AML<\/span>\u60a3\u8005\u5fc5\u987b\u786e\u5b9a\u5176\u5916\u5468\u8840\u6216\u9aa8\u9ad3\u5177\u6709<span>FLT3<\/span>\u7a81\u53d8<span>[<\/span>\u5185\u90e8\u4e32\u8054\u91cd\u590d\uff08<span>ITD<\/span>\uff09\u6216\u916a\u6c28\u9178\u6fc0\u9176\u57df\uff08<span>TKD<\/span>\uff09<span>]<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u5f53\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\u8bc4\u4f30\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u8840\u6db2\u5b66\u3001\u7ec6\u80de\u9057\u4f20\u5b66\u548c\u5206\u5b50\u751f\u7269\u5b66\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bcc\u9a6c\u9178\u5409\u745e\u66ff\u5c3c\u7247\u7684\u63a8\u8350\u8d77\u59cb\u5242\u91cf\u4e3a<span>120mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u6bcf<span>28<\/span>\u5929\u4e3a\u4e00\u4e2a\u6cbb\u7597\u5468\u671f\u3002\u53e3\u670d\u7ed9\u836f\uff0c\u6574\u7247\u7528\u6c34\u9001\u670d\uff0c\u4e0d\u5f97\u63b0\u5f00\u6216\u78be\u788e\uff0c\u6bcf\u5929\u5927\u7ea6\u540c\u4e00\u65f6\u95f4\u670d\u7528\u3002\u5982\u6f0f\u670d\u6216\u672a\u5728\u539f\u8ba1\u5212\u65f6\u95f4\u670d\u836f\uff0c\u53ef\u4ee5\u5728\u5f53\u65e5\u5185\u5c3d\u5feb\u670d\u7528\uff0c\u4f46\u5e94\u5728\u4e0b\u4e00\u6b21\u6309\u8ba1\u5212\u670d\u836f\u7684<span> 12 <\/span>\u5c0f\u65f6\u524d\u8865\u670d\uff0c\u7b2c\u4e8c\u5929\u7ee7\u7eed\u6b63\u5e38\u8ba1\u5212\u65f6\u95f4\u670d\u836f\u3002\u6cbb\u7597\u4e2d\u6839\u636e\u7597\u6548\u548c\u4e0d\u826f\u53cd\u5e94\u8c03\u6574\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u6cbb\u7597\u5e94\u6301\u7eed\u8fdb\u884c\uff0c\u76f4\u81f3\u60a3\u8005\u4e0d\u518d\u6709\u4e34\u5e8a\u83b7\u76ca\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u7531\u4e8e\u4e34\u5e8a\u7f13\u89e3\u53ef\u80fd\u4f1a\u5ef6\u8fdf\uff0c\u56e0\u6b64\uff0c\u5e94\u8003\u8651\u4ee5\u5904\u65b9\u5242\u91cf\u6301\u7eed\u6cbb\u7597\u957f\u8fbe\u81f3<span>6<\/span>\u4e2a\u6cbb\u7597\u5468\u671f\uff0c\u786e\u4fdd\u6709\u5145\u5206\u65f6\u95f4\u8fbe\u5230\u4e34\u5e8a\u7f13\u89e3\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u6cbb\u7597<span>4<\/span>\u5468\u540e\u672a\u5b9e\u73b0\u4ee5\u4e0b\u51e0\u79cd\u60c5\u5f62\u4e4b\u4e00\uff0c\u5219\u5e94\u5728\u60a3\u8005\u8010\u53d7\u6216\u4e34\u5e8a\u6709\u4fdd\u8bc1\u7684\u60c5\u51b5\u4e0b\uff0c\u5c06\u5242\u91cf\u589e\u81f3<span>200mg<\/span>\u6bcf\u5929\u4e00\u6b21\uff1a\uff08<span>1<\/span>\uff09\u5b8c\u5168\u7f13\u89e3\uff08<span>CR<\/span>\uff09\u3002\uff08<span>2<\/span>\uff09\u9664\u8840\u5c0f\u677f\u6062\u590d\u4e0d\u5b8c\u5168\uff08\u8840\u5c0f\u677f\uff1c<span>100\u00d710<sup>9<\/sup>\/L<\/span>\uff09\uff0c\u5176\u4ed6\u6807\u51c6\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\uff08<span>CRp<\/span>\uff09\u3002\uff08<span>3<\/span>\uff09\u9664\u4ecd\u6709\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff08\u4e2d\u6027\u7c92\u7ec6\u80de\uff1c<span>1\u00d710<sup>9<\/sup>\/L<\/span>\uff09\uff0c\u4f34\u6216\u4e0d\u4f34\u8840\u5c0f\u677f\u5b8c\u5168\u6062\u590d\uff0c\u5176\u4ed6\u6807\u51c6\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\uff08<span>CRi<\/span>\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u5728\u6cbb\u7597\u5f00\u59cb\u524d\uff0c\u7b2c<span>1<\/span>\u4e2a\u6cbb\u7597\u5468\u671f\u7684\u6bcf\u5468\uff0c\u7b2c<span>2<\/span>\u4e2a\u6cbb\u7597\u5468\u671f\u7684\u7b2c<span>2<\/span>\u5468\uff0c\u548c\u4e4b\u540e\u7684\u6bcf\u4e2a\u6cbb\u7597\u5468\u671f\u8fdb\u884c\u8840\u7ec6\u80de\u8ba1\u6570\u548c\u8840\u6db2\u751f\u5316\u8bc4\u4f30\uff08\u5305\u62ec\u808c\u9178\u78f7\u9178\u6fc0\u9176\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u5728\u7ed9\u4e88\u672c\u54c1\u6cbb\u7597\u5f00\u59cb\u524d\uff0c\u7b2c<span>1<\/span>\u4e2a\u5468\u671f\u7684\u7b2c<span>8<\/span>\u5929\u548c\u7b2c<span>15<\/span>\u5929\uff0c\u4ee5\u53ca\u540e\u7eed<span>2<\/span>\u4e2a\u5468\u671f\u6cbb\u7597\u5f00\u59cb\u524d\u8fdb\u884c\u5fc3\u7535\u56fe\u68c0\u67e5\u3002<span>QTc<\/span>\u95f4\u671f\u5ef6\u957f\uff08\uff1e<span>500ms<\/span>\uff09\u7684\u60a3\u8005\u5e94\u4e2d\u65ad\u6cbb\u7597\u5e76\u964d\u4f4e\u672c\u54c1\u7684\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e38\u89c1\u4e0d\u826f\u4e8b\u4ef6\uff08\u2265<span>10%<\/span>\uff09\u4e3a<span>ALT<\/span>\u5347\u9ad8\u3001<span>AST<\/span>\u5347\u9ad8\u3001\u8d2b\u8840\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u6027\u53d1\u70ed\u3001\u8840\u5c0f\u677f\u8ba1\u6570\u51cf\u5c11\u3001\u8179\u6cfb\u3001\u6076\u5fc3\u3001\u8840\u78b1\u6027\u78f7\u9178\u9176\u5347\u9ad8\u3001\u75b2\u4e4f\u3001\u767d\u7ec6\u80de\u8ba1\u6570\u51cf\u5c11\u3001\u8840\u808c\u9178\u78f7\u9178\u6fc0\u9176\u5347\u9ad8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u4e3b\u8981\u7ecf<span>CYP3A4<\/span>\u9176\u4ee3\u8c22\uff0c\u5e94\u907f\u514d\u4e0e\u5f3a\u6548<span>CYP3A\/P-<\/span>\u7cd6\u86cb\u767d\u8bf1\u5bfc\u5242\u8054\u5408\u4f7f\u7528\u3002\u4e0e\u5f3a\u6548<span>CYP3A<\/span>\u548c<span>\/<\/span>\u6216<span>P-<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\u65f6\uff0c\u672c\u54c1\u7684\u66b4\u9732\u91cf\u589e\u52a0\u7ea6<span>1.5<\/span>\u500d\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u53ef\u80fd\u964d\u4f4e\u9776\u5411<span>5HT2B<\/span>\u53d7\u4f53\u6216\u03c3\u975e\u7279\u5f02\u6027\u53d7\u4f53\u7684\u836f\u7269\uff08\u5982\u827e\u53f8\u897f\u915e\u666e\u5170\u3001\u6c1f\u897f\u6c40\u3001\u820d\u66f2\u6797\uff09\u7684\u7597\u6548\u3002\u9664\u975e\u786e\u8ba4\u60a3\u8005\u83b7\u76ca\u5927\u4e8e\u98ce\u9669\uff0c\u5426\u5219\u5e94\u907f\u514d\u8fd9\u4e9b\u836f\u7269\u4e0e\u672c\u54c1\u7684\u8054\u5408\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u4e0d\u5efa\u8bae\u5728\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u4f7f\u7528\u672c\u54c1\uff0c\u56e0\u4e3a\u5c1a\u672a\u5728\u8be5\u4eba\u7fa4\u4e2d\u8fdb\u884c\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u8bc4\u4ef7\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">12.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u7fa4\u4f53\u836f\u4ee3\u52a8\u529b\u5b66\u6a21\u578b\u8bc4\u4ef7\uff0c\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u5c1a\u65e0\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u4e34\u5e8a\u7ecf\u9a8c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e94\u3001\u4f0a\u5e03\u66ff\u5c3c<span> Ibrutinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>140mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5355\u836f\u9002\u7528\u4e8e\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">MCL<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff09<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5355\u836f\u6cbb\u7597\u521d\u6cbb\u53ca\u590d\u53d1\u7684\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5<span>\/<\/span>\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5355\u836f\u6216\u4e0e\u5229\u59a5\u6614\u5355\u6297\u8054\u5408\u6cbb\u7597\u521d\u6cbb\u53ca\u590d\u53d1\u7684\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u5e03\u66ff\u5c3c\u7528\u4e8e<span>CLL<\/span>\u6cbb\u7597\u524d\uff0c\u5e94\u8fdb\u884c\u4e25\u683c\u4e34\u5e8a\u8bc4\u4f30\uff0c\u5982\u679c\u60a3\u8005\u6709\u660e\u786e<span>del<\/span>\uff08<span>17p<\/span>\uff09\uff0c\u9009<span>BTK<\/span>\u6291\u5236\u5242\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u8bca\u65ad\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u6216\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u6216\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff0c\u6839\u636e\u8bca\u65ad\u4e0d\u540c\uff0c\u6cbb\u7597\u5242\u91cf\u4e0d\u540c\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u8be5\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\u8bc4\u4f30\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u53cd\u5e94\u53ca\u6bd2\u6027\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597<span>MCL<\/span>\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>560mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\uff1b\u6cbb\u7597<span>CLL\/SLL<\/span>\u548c\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>420mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u63a8\u8350\u5242\u91cf\u662f\u6bcf\u5929<span>140mg<\/span>\u3002\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u907f\u514d\u4f7f\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53e3\u670d\u7ed9\u836f\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u6bcf\u5929\u7684\u7528\u836f\u65f6\u95f4\u5927\u81f4\u56fa\u5b9a\u3002\u5e94\u7528\u6c34\u9001\u670d\u6574\u7c92\u80f6\u56ca\u3002\u8bf7\u52ff\u6253\u5f00\u3001\u5f04\u7834\u6216\u5480\u56bc\u80f6\u56ca\u3002\u5982\u679c\u672a\u5728\u8ba1\u5212\u65f6\u95f4\u670d\u7528\u672c\u54c1\uff0c\u53ef\u4ee5\u5728\u5f53\u5929\u5c3d\u5feb\u670d\u7528\uff0c\u7b2c\u4e8c\u5929\u7ee7\u7eed\u5728\u6b63\u5e38\u8ba1\u5212\u65f6\u95f4\u670d\u836f\u3002\u8bf7\u52ff\u989d\u5916\u670d\u7528\u672c\u54c1\u4ee5\u5f25\u8865\u6f0f\u670d\u5242\u91cf\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51fa\u73b0\u4efb\u4f55\u2265<span>3<\/span>\u7ea7\u975e\u8840\u6db2\u5b66\u6bd2\u6027\u3001\u2265<span>3<\/span>\u7ea7\u4f34\u611f\u67d3\u6216\u53d1\u70ed\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u6216\u8005<span>4<\/span>\u7ea7\u8840\u6db2\u5b66\u6bd2\u6027\u65f6\uff0c\u5e94\u4e2d\u65ad\u6cbb\u7597\u3002\u5f85\u6bd2\u6027\u75c7\u72b6\u6d88\u9000\u81f3<span>1<\/span>\u7ea7\u6216\u57fa\u7ebf\u6c34\u5e73\uff08\u6062\u590d\uff09\u65f6\uff0c\u53ef\u4ee5\u8d77\u59cb\u5242\u91cf\u91cd\u65b0\u5f00\u59cb\u6cbb\u7597\u3002\u5982\u679c\u8be5\u6bd2\u6027\u518d\u6b21\u53d1\u751f\uff0c\u5e94\u5c06\u5242\u91cf\u51cf\u5c11<span>140mg<\/span>\uff0c\u5982\u6709\u9700\u8981\uff0c\u53ef\u4ee5\u8003\u8651\u518d\u51cf\u5c11<span>140mg<\/span>\u3002\u5982\u679c\u5728\u4e24\u6b21\u5242\u91cf\u964d\u4f4e\u540e\u8be5\u6bd2\u6027\u4ecd\u7136\u5b58\u5728\u6216\u518d\u6b21\u53d1\u751f\uff0c\u5e94\u505c\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a5\u53d7\u672c\u836f\u6cbb\u7597\u7684<span>MCL<\/span>\u60a3\u8005\u6700\u5e38\u53d1\u751f\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u2265<span>20%<\/span>\uff09\u662f\u8179\u6cfb\u3001\u51fa\u8840\uff08\u5982\u9752\u80bf\uff09\u3001\u75b2\u4e4f\u3001\u9aa8\u9abc\u808c\u8089\u75bc\u75db\u3001\u6076\u5fc3\u3001\u4e0a\u547c\u5438\u9053\u611f\u67d3\u3001\u54b3\u55fd\u548c\u76ae\u75b9\u3002\u6700\u5e38\u89c1\u7684<span>3<\/span>\u7ea7\u6216<span>4<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff08\u2265<span>5%<\/span>\uff09\u662f\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3001\u611f\u67d3\u6027\u80ba\u708e\u548c\u8d2b\u8840\u3002\u63a5\u53d7\u672c\u836f\u6cbb\u7597\u7684<span>CLL<\/span>\u6216<span>SLL<\/span>\u60a3\u8005\u6700\u5e38\u53d1\u751f\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u2265<span>20%<\/span>\uff09\u662f\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3001\u8d2b\u8840\u3001\u8179\u6cfb\u3001\u9aa8\u9abc\u808c\u8089\u75bc\u75db\u3001\u6076\u5fc3\u3001\u76ae\u75b9\u3001\u9752\u80bf\u3001\u75b2\u4e4f\u3001\u53d1\u70ed\u548c\u51fa\u8840\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u516d\u3001\u8d1d\u6797\u59a5\u6b27\u5355\u6297<span> Blinatumomab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7c89\u9488\u5242\uff1a<span>35<\/span>\u03bc<span>g\/<\/span>\u74f6\uff0c\u53e6\u5305\u542b<span>1<\/span>\u74f6<span>10ml<\/span>\u9759\u8109\u8f93\u6ce8\u6eb6\u6db2\u7a33\u5b9a\u5242<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u7528\u4e8e\u6210\u4eba\u590d\u53d1\u6216\u96be\u6cbb\u6027\u524d\u4f53<span>B<\/span>\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u5242\u91cf\uff1a\u2265<span>45kg<\/span>\u4f53\u91cd\u7684\u60a3\u8005\u63a5\u53d7\u56fa\u5b9a\u5242\u91cf\u7ed9\u836f\uff0c\uff1c<span>45kg<\/span>\u4f53\u91cd\u7684\u60a3\u8005\u6839\u636e\u4f53\u8868\u9762\u79ef\u8ba1\u7b97\u5242\u91cf\u3002\u96be\u6cbb\u53ca\u590d\u53d1\u75be\u75c5\u7684\u60a3\u8005\u9700\u5728\u7b2c\u4e00\u6cbb\u7597\u5468\u671f\u7684\u7b2c<span>1<\/span>\uff5e<span>7<\/span>\u5929\u4ece\u4f4e\u5242\u91cf\u8d77\u59cb\uff0c\u4f53\u91cd\u2265<span>45kg<\/span>\u8005\u7ed9\u4e88\u56fa\u5b9a\u5242\u91cf<span>9<\/span>\u03bc<span>g\/d<\/span>\uff0c\uff1c<span>45kg<\/span>\u8005\u6839\u636e\u4f53\u8868\u9762\u79ef\u7ed9\u4e88<span>5<\/span>\u03bc<span>g\/<\/span>\uff08<span>m<sup>2<\/sup><\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2022<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">d<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff09\uff1b\u7b2c<span>8<\/span>\u5929\u8d77\u81f3\u7b2c<span>28<\/span>\u5929\u589e\u52a0\u81f3\u8db3\u5242\u91cf\u5373\u2265<span>45kg<\/span>\u8005<span>28<\/span>\u03bc<span>g\/d<\/span>\uff0c\uff1c<span>45kg<\/span>\u8005<span>15<\/span>\u03bc<span>g\/<\/span>\uff08<span>m<sup>2<\/sup><\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2022<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">d<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff09\u3002\u7528\u4e8e\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\u9633\u6027\u60a3\u8005\u65e0\u9700\u7ecf\u8fc7\u5242\u91cf\u722c\u5761\uff0c\u8d77\u59cb\u5373\u7ed9\u4e88\u8db3\u5242\u91cf<span>28<\/span>\u03bc<span>g\/d<\/span>\uff08\u2265<span>45kg<\/span>\uff09\u6216<span>15<\/span>\u03bc<span>g\/<\/span>\uff08<span>m<sup>2<\/sup><\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2022<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">d<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff09\uff08\uff1c<span>45kg<\/span>\uff09\u3002\u5982\u6cbb\u7597\u671f\u95f4\u51fa\u73b0\u4e2d\u65ad\u7ed9\u836f\uff08\u5982\u56e0\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\uff09\uff0c\u672a\u8d85\u8fc7<span>7<\/span>\u5929\u53ef\u7ee7\u7eed\u8be5\u5468\u671f\u6cbb\u7597\u76f4\u81f3\u5171\u8f93\u6ce8<span>28<\/span>\u5929\uff0c\u4e2d\u65ad\u7ed9\u836f\u8d85\u8fc7<span>7<\/span>\u5929\u5219\u9700\u91cd\u65b0\u5f00\u59cb\u65b0\u7684\u6cbb\u7597\u5468\u671f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u7597\u7a0b\uff1a\u96be\u6cbb\u53ca\u590d\u53d1\u75be\u75c5\u60a3\u8005\u7684\u7597\u7a0b\u6700\u591a\u5305\u542b<span>2<\/span>\u4e2a\u5468\u671f\u7684\u8bf1\u5bfc\u6cbb\u7597\u3001\u4e4b\u540e<span>3<\/span>\u4e2a\u5468\u671f\u7684\u5de9\u56fa\u6cbb\u7597\u53ca\u5e8f\u8d2f\u6700\u591a<span>4<\/span>\u4e2a\u5468\u671f\u7684\u6301\u7eed\u6cbb\u7597\u3002<span>1<\/span>\u4e2a\u8bf1\u5bfc\u6216\u5de9\u56fa\u6cbb\u7597\u5468\u671f\u5171<span>42<\/span>\u5929\uff0c\u7531<span>28<\/span>\u5929\u8fde\u7eed\u7684\u9759\u8109\u8f93\u6ce8\u671f\u548c\u968f\u540e\u7684<span>14<\/span>\u5929\u65e0\u6cbb\u7597\u95f4\u6b47\u671f\u7ec4\u6210\uff0c<span>1<\/span>\u4e2a\u6301\u7eed\u6cbb\u7597\u5468\u671f\u5305\u62ec<span>28<\/span>\u5929\u8fde\u7eed\u9759\u8109\u8f93\u6ce8\u548c\u4e4b\u540e\u7684<span>56<\/span>\u5929\u65e0\u6cbb\u7597\u95f4\u6b47\u671f\uff08\u5171<span>84<\/span>\u5929\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5730\u585e\u7c73\u677e\u9884\u5148\u7528\u836f\uff1a\u5bf9\u4e8e\u6210\u4eba\u60a3\u8005\uff0c\u5728\u672c\u54c1\u6bcf\u4e2a\u5468\u671f\u5185\u7b2c\u4e00\u6b21\u7ed9\u836f\u524d<span>1<\/span>\u5c0f\u65f6\uff0c\u5347\u9ad8\u5242\u91cf\u524d\uff08\u4f8b\u5982\u7b2c<span>1<\/span>\u5468\u671f\u7b2c<span>8<\/span>\u5929\uff09\uff0c\u4ee5\u53ca\u5728\u4e2d\u65ad\u6cbb\u7597<span>4<\/span>\u5c0f\u65f6\u6216\u4ee5\u4e0a\u540e\u91cd\u542f\u8f93\u6ce8\u65f6\uff0c\u7528\u836f\u524d\u9884\u5148\u7ed9\u4e88<span>20mg<\/span>\u7684\u5730\u585e\u7c73\u677e\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9ad8\u80bf\u7624\u8d1f\u8377\u60a3\u8005\u7684\u524d\u671f\u6cbb\u7597\uff1a\u5bf9\u4e8e\u9aa8\u9ad3\u4e2d\u539f\u59cb\u7ec6\u80de\u6bd4\u4f8b\u2265<span>50%<\/span>\u6216\u5916\u5468\u8840\u539f\u59cb\u7ec6\u80de\u8ba1\u6570\uff1e<span>15<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u7684\u60a3\u8005\uff0c\u4f7f\u7528\u5730\u585e\u7c73\u677e\u6cbb\u7597\uff08\u4e0d\u8d85\u8fc7<span>24mg\/d<\/span>\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u672c\u54c1\u6cbb\u7597\u524d\u548c\u6cbb\u7597\u671f\u95f4\u8fdb\u884c\u9798\u5185\u6ce8\u5c04\u9884\u9632\u6027\u5316\u7597\uff0c\u4ee5\u9632\u6b62\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u590d\u53d1\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u7684\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u5c1a\u65e0\u8d1d\u6797\u59a5\u6b27\u5355\u6297\u7528\u4e8e\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\uff08\u808c\u9150\u6e05\u9664\u7387\uff1c<span>30ml\/min<\/span>\uff09\u6216\u6b63\u63a5\u53d7\u8840\u6db2\u900f\u6790\u7684\u60a3\u8005\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u4fe1\u606f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u6797\u59a5\u6b27\u5355\u6297\u5f00\u59cb\u6cbb\u7597\u65f6\u5bfc\u81f4\u7684\u7ec6\u80de\u56e0\u5b50\u77ed\u6682\u91ca\u653e\u53ef\u80fd\u4f1a\u6291\u5236<span>CYP450<\/span>\u9176\u3002\u5728\u5408\u5e76\u4f7f\u7528<span>CYP450<\/span>\u5e95\u7269\uff08\u5c24\u5176\u662f\u5177\u6709\u72ed\u7a84\u6cbb\u7597\u6307\u6570\u7684<span>CYP450<\/span>\u5e95\u7269\uff09\u7684\u60a3\u8005\u4e2d\uff0c\u7b2c<span>1<\/span>\u5468\u671f\u524d<span>9<\/span>\u5929\u548c\u7b2c<span>2<\/span>\u5468\u671f\u524d<span>2<\/span>\u5929\u53d1\u751f\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u7684\u98ce\u9669\u6700\u9ad8\u3002\u5e94\u5f53\u76d1\u6d4b\u8fd9\u4e9b\u60a3\u8005\u4e2d\u7684\u6bd2\u6027\uff08\u5982\u534e\u6cd5\u6797\uff09\u6216\u836f\u7269\u6d53\u5ea6\uff08\u5982\u73af\u5b62\u9709\u7d20\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff1a\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5728<span>15%<\/span>\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u60a3\u8005\u548c<span>7%<\/span>\u7684\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\u9633\u6027\u7684\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u60a3\u8005\u62a5\u544a\u4e86\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\u3002\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\u53d1\u751f\u4e2d\u4f4d\u65f6\u95f4\u4e3a\u8f93\u6ce8\u5f00\u59cb\u540e<span>2<\/span>\u5929\uff0c\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\u6d88\u9000\u4e2d\u4f4d\u65f6\u95f4\u4e3a<span>5<\/span>\u5929\u3002\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\u7684\u8868\u73b0\u5305\u62ec\u53d1\u70ed\u3001\u5934\u75db\u3001\u6076\u5fc3\u3001\u4e4f\u529b\u3001\u4f4e\u8840\u538b\u3001<span>ALT<\/span>\u5347\u9ad8\u3001<span>AST<\/span>\u5347\u9ad8\u3001\u603b\u80c6\u7ea2\u7d20\u5347\u9ad8\u4ee5\u53ca\u5f25\u6563\u6027\u8840\u7ba1\u5185\u51dd\u8840\u7b49\u3002\u63a5\u53d7\u8d1d\u6797\u59a5\u6b27\u5355\u6297\u6cbb\u7597\u540e\u7684\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\u7684\u8868\u73b0\u4e0e\u8f93\u6db2\u53cd\u5e94\u3001\u6bdb\u7ec6\u8840\u7ba1\u6e17\u6f0f\u7efc\u5408\u5f81\u548c\u566c\u8840\u7ec6\u80de\u6027\u7ec4\u7ec7\u7ec6\u80de\u589e\u751f\u75c7<span>\/<\/span>\u5de8\u566c\u7ec6\u80de\u6fc0\u6d3b\u7efc\u5408\u5f81\u7684\u8868\u73b0\u91cd\u53e0\u3002\u5927\u591a\u6570\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\u662f\u53ef\u9006\u7684\uff0c\u5e76\u4e14\u53ef\u5728\u8d1d\u6797\u59a5\u6b27\u5355\u6297\u7ed9\u836f\u524d\u901a\u8fc7\u8bc6\u522b\u9ad8\u5371\u75c5\u4eba\u3001\u5730\u585e\u7c73\u677e\u9884\u5148\u7528\u836f\u53ca\u9010\u6b65\u589e\u52a0\u5242\u91cf\u7684\u7ed9\u836f\u65b9\u5f0f\u8fdb\u884c\u9884\u9632\u3002\u4f4e\u7ea7\u522b\uff08<span>1<\/span>\uff5e<span>2<\/span>\u7ea7\uff09\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\u65e0\u9700\u6682\u505c\u8d1d\u6797\u59a5\u6b27\u5355\u6297\u7528\u836f\uff0c\u53ef\u5728\u5bc6\u5207\u76d1\u6d4b\u76f8\u5173\u6307\u6807\u53ca\u751f\u547d\u4f53\u5f81\u4e0b\u7ed9\u4e88\u5bf9\u75c7\u6cbb\u7597\u3002\u5bf9\u4e8e\u4e25\u91cd\uff08\u2265<span>3<\/span>\u7ea7\uff09\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff0c<span>3<\/span>\u7ea7\u9700\u6682\u505c\u7ed9\u836f\uff0c<span>4<\/span>\u7ea7\u8003\u8651\u6c38\u4e45\u505c\u836f\uff0c\u5e76\u9700\u8981\u4e25\u5bc6\u76d1\u6d4b\u751f\u547d\u4f53\u5f81\u5e76\u8fc5\u901f\u7ed9\u4e88\u79ef\u6781\u7684\u6cbb\u7597\uff0c\u6839\u636e\u4e34\u5e8a\u6307\u5f81\u7ed9\u4e88\u7cd6\u76ae\u8d28\u6fc0\u7d20\uff08\u9996\u9009\u5730\u585e\u7c73\u677e\uff09\u548c<span>IL-6<\/span>\u53d7\u4f53\u963b\u6ede\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u795e\u7ecf\u7cfb\u7edf\u6bd2\u6027\uff1a\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u795e\u7ecf\u7cfb\u7edf\u6bd2\u6027\u53d1\u751f\u4e8e\u5927\u7ea6<span>65%<\/span>\u7684\u60a3\u8005\u3002\u53d1\u751f\u9996\u9879\u4e8b\u4ef6\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a\u672c\u54c1\u6cbb\u7597\u7684\u524d<span>2<\/span>\u5468\u5185\uff0c\u5927\u591a\u6570\u795e\u7ecf\u7cfb\u7edf\u4e8b\u4ef6\u53ef\u4ee5\u6d88\u9000\u3002\u795e\u7ecf\u7cfb\u7edf\u6bd2\u6027\u7684\u6700\u5e38\u89c1\uff08\u2265<span>10%<\/span>\uff09\u8868\u73b0\u4e3a\u5934\u75db\u548c\u9707\u98a4\uff1b\u795e\u7ecf\u7cfb\u7edf\u6bd2\u6027\u7684\u7279\u5f81\u56e0\u5e74\u9f84\u7ec4\u800c\u5f02\u3002\u5f00\u59cb\u672c\u54c1\u7ed9\u836f\u540e\uff0c\u5927\u7ea6<span>13%<\/span>\u7684\u60a3\u8005\u53d1\u751f\u2265<span>3<\/span>\u7ea7\uff08\u4e25\u91cd\u3001\u5371\u53ca\u751f\u547d\u6216\u5bfc\u81f4\u6b7b\u4ea1\uff09\u7684\u795e\u7ecf\u7cfb\u7edf\u6bd2\u6027\uff0c\u5305\u62ec\u8111\u75c5\u3001\u62bd\u6410\u3001\u8a00\u8bed\u969c\u788d\u3001\u610f\u8bc6\u969c\u788d\u3001\u5b9a\u5411\u969c\u788d\u3001\u534f\u8c03\u969c\u788d\u548c\u5e73\u8861\u969c\u788d\u3002\u795e\u7ecf\u7cfb\u7edf\u6bd2\u6027\u7684\u8868\u73b0\u5305\u62ec\u9885\u795e\u7ecf\u75be\u75c5\u3002\u6240\u6709\u2265<span>3<\/span>\u7ea7\u7684\u795e\u7ecf\u7cfb\u7edf\u6bd2\u6027\u5747\u5e94\u6682\u505c\u7ed9\u836f\u5e76\u8fdb\u884c\u4f53\u683c\u68c0\u67e5\u3001\u751f\u547d\u4f53\u5f81\u76d1\u6d4b\u53ca\u5b89\u5168\u6027\u76f8\u5173\u5b9e\u9a8c\u5ba4\u68c0\u67e5\uff0c\u540c\u65f6\u6839\u636e\u60a3\u8005\u60c5\u51b5\u7ed9\u4e88\u5730\u585e\u7c73\u677e\u6cbb\u7597\uff0c\u6bcf\u5929\u6700\u5927\u5242\u91cf\u4e0d\u8d85\u8fc7<span>24mg\/d<\/span>\uff0c\u5730\u585e\u7c73\u677e\u51cf\u91cf\u65f6\u5e94\u4e8e<span>4<\/span>\u5929\u5185\u5b8c\u6210\u51cf\u91cf\u76f4\u81f3\u505c\u836f\u3002\u652f\u6301\u6027\u6cbb\u7597\u5982\u766b\u75eb\u53d1\u4f5c\u7684\u6297\u766b\u75eb\u836f\u5e94\u7531\u4e13\u79d1\u533b\u751f\u5224\u65ad\u540e\u914c\u60c5\u8003\u8651\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5176\u4ed6\u6cbb\u7597\uff1a\u8d1d\u6797\u59a5\u6b27\u5355\u6297\u53ef\u4ee5\u7528\u4e8e<span>CR1<\/span>\u6216<span>CR2<\/span>\u4f34\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\u9633\u6027\u7684\u6210\u4eba\u53ca\u513f\u7ae5\u524d\u4f53<span>B<\/span>\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u60a3\u8005\uff0c\u4ee5\u53ca\u513f\u7ae5\u590d\u53d1\u6216\u96be\u6cbb\u6027\u524d\u4f53<span>B<\/span>\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08\u5168\u7403\u5176\u4ed6\u56fd\u5bb6\u5df2\u83b7\u6279\u7684\u9002\u5e94\u8bc1\uff09\u3002\u540c\u65f6\u5df2\u6709\u4e0e\u4e8c\u4ee3\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u8fbe\u6c99\u66ff\u5c3c\u8054\u5408\u7528\u4e8e\u65b0\u8bca\u65ad\u7684\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u7684\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08\u2161\u671f\u4e34\u5e8a\u7814\u7a76\uff09\uff0c\u53ca\u4e0e\u4e09\u4ee3\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u535a\u7eb3\u66ff\u5c3c\u8054\u5408\u7528\u4e8e\u65b0\u8bca\u65ad\u53ca\u590d\u53d1\u6216\u96be\u6cbb\u6027\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u7684\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08\u2161\u671f\u4e34\u5e8a\u7814\u7a76\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e03\u3001\u7ef4\u5948\u514b\u62c9 <span>Venetoclax<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>10mg<\/span>\u3001<span>50mg<\/span>\u3001<span>100mg <\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0e\u963f\u624e\u80de\u82f7\u8054\u5408\u7528\u4e8e\u6cbb\u7597\u56e0\u5408\u5e76\u75c7\u4e0d\u9002\u5408\u63a5\u53d7\u5f3a\u8bf1\u5bfc\u5316\u7597\uff0c\u6216\u8005\u5e74\u9f84\u2265<span>75<\/span>\u5c81\u7684\u65b0\u8bca\u65ad\u7684\u6210\u4eba\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u4e0e\u963f\u624e\u80de\u82f7\u8054\u7528\u6cbb\u7597\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff0c\u5728\u7b2c<span>1<\/span>\u4e2a\u7597\u7a0b\u5f00\u59cb\u65f6\uff0c\u672c\u54c1\u9700\u8981\u8fdb\u884c\u5242\u91cf\u722c\u5761\uff0c\u5177\u4f53\u65b9\u6cd5\u662f\uff1a\u7ef4\u5948\u514b\u62c9<span>100mg d1<\/span>\uff0c<span>200mg d2<\/span>\uff0c<span>400mgd3<\/span>\uff0c\u540e<span>400mg\/d<\/span>\u7ee7\u7eed\u6cbb\u7597\uff0c\u6bcf\u7597\u7a0b<span>28<\/span>\u5929\u3002\u672c\u54c1\u6309\u7597\u7a0b\u4e0e\u963f\u624e\u80de\u82f7\u8054\u7528\u7ed9\u836f\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u53d1\u751f\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5e94\u5728\u9910\u540e<span>30<\/span>\u5206\u949f\u5185\u670d\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5e94\u5c3d\u53ef\u80fd\u5728\u6bcf\u5929\u540c\u4e00\u65f6\u95f4\u670d\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5e94\u6574\u7247\u541e\u670d\uff0c\u4e0d\u5f97\u5480\u56bc\u3001\u78be\u788e\u6216\u5728\u541e\u670d\u524d\u63b0\u788e\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u60a3\u8005\u5728\u5e38\u89c4\u670d\u836f\u65f6\u95f4\u7684<span>8<\/span>\u5c0f\u65f6\u5185\u6f0f\u670d\u4e00\u6b21\u672c\u54c1\uff0c\u5e94\u5c3d\u5feb\u8865\u670d\uff0c\u5e76\u6062\u590d\u6bcf\u5929\u5e38\u89c4\u7ed9\u836f\u3002\u82e5\u60a3\u8005\u6f0f\u670d\u672c\u54c1\u5df2\u8d85\u8fc7<span>8<\/span>\u5c0f\u65f6\uff0c\u5219\u4e0d\u9700\u8981\u8865\u670d\uff0c\u53ea\u9700\u5728\u7b2c\u4e8c\u5929\u6062\u590d\u5e38\u89c4\u7ed9\u836f\u3002\u5982\u60a3\u8005\u5728\u6b63\u5e38\u7ed9\u836f\u540e\u53d1\u751f\u5455\u5410\uff0c\u5728\u5455\u5410\u5f53\u5929\u4e0d\u9700\u8981\u518d\u6b21\u670d\u7528\u672c\u54c1\uff0c\u5728\u5e38\u89c4\u670d\u836f\u65f6\u95f4\u8fdb\u884c\u4e0b\u6b21\u7ed9\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5728<span>AML<\/span>\u60a3\u8005\u4e2d\u53d1\u751f\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\u98ce\u9669\u76f8\u5bf9\u8f83\u4f4e\uff0c\u4f46\u4ecd\u5e94\u4e88\u4ee5\u8db3\u591f\u91cd\u89c6\u3002\u5efa\u8bae\u5728\u672c\u54c1\u7ed9\u836f\u524d\uff0c\u60a3\u8005\u7684\u767d\u7ec6\u80de\u8ba1\u6570\u5e94\u5c0f\u4e8e<span>25\u00d710<sup>9<\/sup>\/L<\/span>\uff0c\u7ea0\u6b63\u7d0a\u4e71\u7684\u7535\u89e3\u8d28\u3002\u5728\u9996\u6b21\u7ed9\u836f\u524d\u4ee5\u53ca\u5242\u91cf\u722c\u5761\u671f\uff0c\u5e94\u7ed9\u4e88\u5145\u8db3\u7684\u6c34\u5316\u548c\u6297\u9ad8\u5c3f\u9178\u8840\u75c7\u836f\u7269\u3002\u722c\u5761\u671f\u5185\u6bcf\u6b21\u65b0\u5242\u91cf\u7ed9\u836f\u540e<span>6<\/span>\uff5e<span>8<\/span>\u5c0f\u65f6\u4ee5\u53ca\u8fbe\u5230\u6700\u7ec8\u5242\u91cf\u540e<span>24<\/span>\u5c0f\u65f6\uff0c\u5e94\u76d1\u6d4b\u8840\u751f\u5316\u4ee5\u8bc4\u4f30\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\u3002\u5bf9\u4e8e\u6709\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\u98ce\u9669\u7684\u60a3\u8005\uff0c\u53ef\u7ed9\u4e88\u989d\u5916\u63aa\u65bd\u52a0\u5f3a\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\u9884\u9632\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8840\u6db2\u5b66\u6bd2\u6027\u662f\u7ef4\u5948\u514b\u62c9\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u3002\u5728\u8bf1\u5bfc\u6cbb\u7597\u83b7\u5f97\u7f13\u89e3\u524d\uff0c\u5373\u4f7f\u53d1\u751f<span>4<\/span>\u7ea7\u8840\u7ec6\u80de\u51cf\u5c11\uff0c\u4e5f\u4e0d\u5e94\u4e2d\u65ad\u672c\u54c1\u6cbb\u7597\u3002\u5728\u83b7\u5f97\u7f13\u89e3\u540e\u7684\u9996\u4e2a\u7597\u7a0b\u4e2d\u518d\u6b21\u51fa\u73b0<span>4<\/span>\u7ea7\u8840\u7ec6\u80de\u51cf\u5c11\u4e14\u6301\u7eed\u8d85\u8fc7<span>7<\/span>\u5929\uff0c\u4ecd\u5efa\u8bae\u575a\u6301\u8db3\u5242\u91cf\u8db3\u7597\u7a0b\u4f7f\u7528\uff0c\u6cbb\u7597\u7ed3\u675f\u540e\u63a8\u8fdf\u4e0b\u4e00\u7597\u7a0b\u5f00\u59cb\uff0c<a name=\"OLE_LINK4\"><\/a>\u76d1\u6d4b\u8840\u7ec6\u80de\u8ba1\u6570\uff0c\u7b49\u5f85\u8840\u7ec6\u80de\u51cf\u5c11\u6062\u590d\u81f3<span>1<\/span>\u7ea7\u6216<span>2<\/span>\u7ea7\uff0c\u5219\u4ee5\u76f8\u540c\u5242\u91cf\u6062\u590d\u672c\u54c1\u4e0e\u963f\u624e\u80de\u82f7\u7684\u540e\u7eed\u6cbb\u7597\u3002\u82e5\u5728\u540e\u7eed\u7597\u7a0b\u4e2d\u518d\u6b21\u51fa\u73b0<span>4<\/span>\u7ea7\u8840\u7ec6\u80de\u51cf\u5c11\u4e14\u6301\u7eed\u8d85\u8fc7<span>7<\/span>\u5929\uff0c\u53ef\u8003\u8651\u5c06\u7ef4\u5948\u514b\u62c9\u7597\u7a0b\u4ece<span>28<\/span>\u5929\u51cf\u5c11\u81f3<span>21<\/span>\u5929\uff0c\u76d1\u6d4b\u8840\u7ec6\u80de\u8ba1\u6570\uff0c\u7b49\u5f85\u8840\u7ec6\u80de\u51cf\u5c11\u6062\u590d\u81f3<span>1<\/span>\u7ea7\u6216<span>2<\/span>\u7ea7\u518d\u5f00\u59cb\u540e\u7eed\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u4e0e<span>CYP3A<\/span>\u6291\u5236\u5242\u8054\u7528\u65f6\u9700\u8fdb\u884c\u76f8\u5e94\u7684\u8c03\u6574\u5242\u91cf\u3002\u672c\u54c1\u4e0e\u5f3a\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\uff08\u5982\u4f0a\u66f2\u5eb7\u5511\u3001\u4f0f\u7acb\u5eb7\u5511\u3001\u916e\u5eb7\u5511\u7b49\uff09\u8054\u7528\u65f6\uff0c\u7ef4\u5948\u514b\u62c9\u9700\u51cf\u91cf\u81f3<span>100mg\/d<\/span>\uff0c\u82e5\u5904\u4e8e\u5242\u91cf\u722c\u5761\u671f\uff0c\u51cf\u91cf\u65b9\u6cd5\u4e3a\uff1a\u7ef4\u5948\u514b\u62c9<span>10mg d1<\/span>\uff0c<span>20mg d2<\/span>\uff0c<span>50mgd3<\/span>\uff0c<span>100mg d4<\/span>\uff1b\u6cca\u6c99\u5eb7\u5511\u4e5f\u5c5e\u4e8e\u5f3a\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\uff0c\u4f46\u4e0e\u6cca\u6c99\u5eb7\u5511\u8054\u7528\u65f6\uff0c\u7ef4\u5948\u514b\u62c9\u9700\u51cf\u91cf\u81f3<span>70mg\/d<\/span>\uff0c\u82e5\u5904\u4e8e\u5242\u91cf\u722c\u5761\u671f\uff0c\u51cf\u91cf\u65b9\u6cd5\u4e3a\uff1a\u7ef4\u5948\u514b\u62c9<span>10mg d1<\/span>\uff0c<span>20mg d2<\/span>\uff0c<span>50mg d3<\/span>\uff0c<span>70mgd4<\/span>\uff1b\u4e0e\u4e2d\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\uff08\u5982\u6c1f\u5eb7\u5511\u7b49\uff09\u548c<span>P-<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\uff08\u5982\u80fa\u7898\u916e\u3001\u5361\u6258\u666e\u5229\u7b49\uff09\u8054\u7528\u65f6\uff0c\u7ef4\u5948\u514b\u62c9\u9700\u51cf\u91cf<span>50%<\/span>\u3002\u7981\u6b62\u672c\u54c1\u4e0e<span>CYP3A<\/span>\u8bf1\u5bfc\u5242\uff08\u5982\u5229\u798f\u5e73\u3001\u82ef\u59a5\u82f1\u94a0\u3001\u5361\u9a6c\u897f\u5e73\u7b49\uff09\u8054\u5408\u4f7f\u7528\u3002\u672c\u54c1\u4e0e<span>P-<\/span>\u7cd6\u86cb\u767d\u5e95\u7269\uff08\u5982\u5730\u9ad8\u8f9b\u7b49\uff09\u53ca\u534e\u6cd5\u6797\u7b49\u8054\u7528\uff0c\u9700\u5bc6\u5207\u76d1\u6d4b\u5408\u7528\u836f\u7269\u7684\u8840\u836f\u6d53\u5ea6\u3001<span>INR<\/span>\u7b49\u76f8\u5e94\u6307\u6807\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u4e2d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\uff08\u808c\u9150\u6e05\u9664\u7387\u2265<span>15ml\/min<\/span>\uff09\u60a3\u8005\u65e0\u9700\u5242\u91cf\u8c03\u6574\u3002\u8f7b\u5ea6\uff08<span>Child-PughA<\/span>\u7ea7\uff09\u6216\u4e2d\u5ea6\uff08<span>Child-PughB<\/span>\u7ea7\uff09\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\uff08<span>Child-Pugh C<\/span>\u7ea7\uff09\u60a3\u8005\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u65f6\uff0c\u7ed9\u836f\u5242\u91cf\u964d\u4f4e<span>50%<\/span>\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u516b\u3001\u5229\u59a5\u6614\u5355\u6297<span> Rituximab<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6\u3001<span>500mg<\/span>\uff08<span>50ml<\/span>\uff09<span>\/<\/span>\u74f6<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u6cbb\u7597\u6307\u5f81\u7684\u6ee4\u6ce1\u6027\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.CD20<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9633\u6027\u5f25\u6f2b\u5927<span>B<\/span>\u7ec6\u80de\u6027\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08<span>DLBCL<\/span>\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5355\u836f\u7528\u4e8e\u5229\u59a5\u6614\u5355\u6297\u8054\u5408\u5316\u7597\u540e\u8fbe\u5b8c\u5168\u6216\u90e8\u5206\u7f13\u89e3\u540e\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\uff08<span>FL<\/span>\uff09\u60a3\u8005\u7684\u7ef4\u6301\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8054\u5408\u6c1f\u8fbe\u62c9\u6ee8\u548c\u73af\u78f7\u9170\u80fa\uff08<span>FC<\/span>\uff09\u7528\u4e8e\u521d\u6cbb\u590d\u53d1\u6027<span>\/<\/span>\u96be\u6cbb\u6027\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a5\u53d7\u5229\u59a5\u6614\u5355\u6297\u6cbb\u7597\u540e\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u662f\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\uff0c\u4e3b\u8981\u5728\u9996\u6b21\u8f93\u6ce8\u65f6\u53d1\u751f\uff0c\u75c7\u72b6\u53ef\u8868\u73b0\u4e3a\uff1a\u6076\u5fc3\u3001\u7619\u75d2\u3001\u53d1\u70ed\u3001\u98ce\u75b9<span>\/<\/span>\u76ae\u75b9\u3001\u754f\u5bd2\u3001\u5bd2\u6218\u3001\u55b7\u568f\u3001\u8840\u7ba1\u795e\u7ecf\u6027\u6c34\u80bf\u3001\u54bd\u5589\u523a\u6fc0\u3001\u54b3\u55fd\u548c\u652f\u6c14\u7ba1\u75c9\u631b\uff0c\u540c\u65f6\u4f34\u6709\u6216\u4e0d\u4f34\u6709\u4e0e\u836f\u7269\u6cbb\u7597\u76f8\u5173\u7684\u4f4e\u8840\u538b\u6216\u9ad8\u8840\u538b\u3002\u6bcf\u6b21\u6ef4\u6ce8\u5229\u59a5\u6614\u5355\u6297\u524d\u5e94\u9884\u5148\u4f7f\u7528\u6297\u8fc7\u654f\u836f\u7269\u3002\u5982\u679c\u6240\u4f7f\u7528\u7684\u6cbb\u7597\u65b9\u6848\u4e0d\u5305\u62ec\u7cd6\u76ae\u8d28\u6fc0\u7d20\u65f6\uff0c\u8fd8\u5e94\u8be5\u9884\u5148\u4f7f\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u63a5\u53d7\u5229\u59a5\u6614\u5355\u6297\u548c\u6291\u5236\u7ec6\u80de\u589e\u6b96\u836f\u7269\u5316\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u5df2\u62a5\u544a\u53d1\u751f\u4e59\u578b\u809d\u708e\u518d\u6fc0\u6d3b\u7684\u75c5\u4f8b\u3002\u5e94\u5728\u5f00\u59cb\u5229\u59a5\u6614\u5355\u6297\u6cbb\u7597\u524d\u5bf9\u6240\u6709\u60a3\u8005\u6839\u636e\u5f53\u5730\u6307\u5357\u8fdb\u884c\u4e59\u809d\u75c5\u6bd2\u7684\u7b5b\u67e5\uff0c\u81f3\u5c11\u5e94\u5305\u62ec\u4e59\u809d\u8868\u9762\u6297\u539f\u548c\u4e59\u809d\u6838\u5fc3\u6297\u4f53\u6307\u6807\u3002\u4e0d\u5e94\u5bf9\u6d3b\u52a8\u6027\u4e59\u809d\u60a3\u8005\u4f7f\u7528\u5229\u59a5\u6614\u5355\u6297\u8fdb\u884c\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7981\u7528\u4e8e\u4e25\u91cd\u6d3b\u52a8\u6027\u611f\u67d3\u6216\u514d\u75ab\u5e94\u7b54\u4e25\u91cd\u635f\u4f24\uff08\u5982\u4f4e\u7403\u86cb\u767d\u8840\u75c7\uff0c<span>CD4<\/span>\u6216<span>CD8<\/span>\u7ec6\u80de\u8ba1\u6570\u4e25\u91cd\u4e0b\u964d\uff09\u60a3\u8005\u53ca\u4e25\u91cd\u5fc3\u8870<span>[<\/span>\u7ebd\u7ea6\u5fc3\u810f\u75c5\u5b66\u4f1a\uff08<span>NYHA<\/span>\uff09\u5206\u7c7b<a name=\"_Hlk59362002\"><\/a>\u2163\u7ea7<span>]<\/span>\u60a3\u8005\uff1b\u598a\u5a20\u671f\u95f4\u7981\u6b62\u5229\u59a5\u6614\u5355\u6297\u4e0e\u7532\u6c28\u8776\u5464\u8054\u5408\u7528\u836f\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5229\u59a5\u6614\u5355\u6297\u7ed9\u836f\u9700\u8981\u4e25\u683c\u9075\u5faa\u8bf4\u660e\u4e66\u7528\u6cd5\u7528\u91cf\uff0c\u5c24\u5176\u9700\u8981\u6ce8\u610f\u8d77\u59cb\u6ef4\u901f\u7684\u63a7\u5236\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u7528\u836f\u60a3\u8005\u8fdb\u884c\u4e25\u5bc6\u76d1\u62a4\uff0c\u76d1\u6d4b\u662f\u5426\u53d1\u751f\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\u53ca\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9884\u5148\u5b58\u5728\u80ba\u529f\u80fd\u4e0d\u5168\u6216\u80bf\u7624\u80ba\u6d78\u6da6\u7684\u60a3\u8005\u5fc5\u987b\u8fdb\u884c\u80f8\u90e8\u5f71\u50cf\u5b66\u68c0\u67e5\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f7f\u7528\u5229\u59a5\u6614\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u4e0d\u5b9c\u4f7f\u7528\u6d3b\u75c5\u6bd2\u75ab\u82d7\u8fdb\u884c\u63a5\u79cd\uff0c\u53ef\u4ee5\u63a5\u53d7\u975e\u6d3b\u75ab\u82d7\u7684\u63a5\u79cd\uff0c\u4f46\u5bf9\u975e\u6d3b\u75ab\u82d7\u7684\u5e94\u7b54\u7387\u53ef\u80fd\u4f1a\u4e0b\u964d\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e5d\u3001\u7ef4\u5e03\u59a5\u6614\u5355\u6297 <span>BrentuximabVedotin<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7c89\u9488\u5242\uff1a<span>50mg\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027\u7cfb\u7edf\u6027\u95f4\u53d8\u6027\u5927\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u3002\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5468\u56f4\u795e\u7ecf\u75c5\u53d8\uff1a\u7ef4\u5e03\u59a5\u6614\u5355\u6297\u6cbb\u7597\u53ef\u5f15\u8d77\u611f\u89c9\u548c\u8fd0\u52a8\u6027\u5468\u56f4\u795e\u7ecf\u75c5\u53d8\u4e14\u5177\u6709\u7d2f\u79ef\u6548\u5e94\uff0c\u53ef\u80fd\u9700\u8981\u63a8\u8fdf\u7ed9\u836f\u6216\u7ec8\u6b62\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\uff1a\u5355\u836f\u6cbb\u7597\u8f93\u6db2\u53cd\u5e94\u53d1\u751f\u7387\u4e3a<span>13%<\/span>\uff0c<span>3<\/span>\u7ea7\u4e8b\u4ef6\u53d1\u751f\u7387<span>9.8%<\/span>\u3002\u8d85\u654f\u53cd\u5e94\u53d1\u751f\u5c11\u89c1\uff0c\u5982\u53d1\u751f\u5e94\u7acb\u5373\u7ec8\u6b62\u8f93\u6ce8\u5e76\u7ed9\u4e88\u76f8\u5e94\u5904\u7406\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8840\u6db2\u6bd2\u6027\uff1a\u6bcf\u6b21\u7ed9\u836f\u524d\uff0c\u5e94\u76d1\u6d4b\u5168\u8840\u7ec6\u80de\u8ba1\u6570\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\uff1a\u80bf\u7624\u589e\u6b96\u8fc5\u901f\u548c\u80bf\u7624\u8d1f\u8377\u9ad8\u7684\u60a3\u8005\u53d1\u751f\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\u7684\u98ce\u9669\u8f83\u9ad8\uff0c\u5e94\u5bc6\u5207\u76d1\u6d4b\u5e76\u91c7\u53d6\u9002\u5f53\u7684\u63aa\u65bd\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e25\u91cd\u76ae\u80a4\u53cd\u5e94\uff1a\u5305\u62ec<span>Stevens-Johnson<\/span>\u7efc\u5408\u5f81\u548c\u4e2d\u6bd2\u6027\u8868\u76ae\u574f\u6b7b\u677e\u89e3\u75c7\u3002\u82e5\u53d1\u751f\u5e94\u7ec8\u6b62\u7ef4\u5e03\u59a5\u6614\u5355\u6297\u7ed9\u836f\uff0c\u5e76\u5e94\u63d0\u4f9b\u9002\u5f53\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80ba\u6bd2\u6027\uff1a\u5305\u62ec\u80ba\u708e\u3001\u95f4\u8d28\u6027\u80ba\u708e\u548c\u6025\u6027\u547c\u5438\u7a98\u8feb\u7efc\u5408\u5f81\uff0c\u5e94\u76d1\u6d4b\u5e76\u907f\u514d\u4e0e\u535a\u6765\u9709\u7d20\u5408\u5e76\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ef4\u5e03\u59a5\u6614\u5355\u6297\u4e0e<span>CYP3A4<\/span>\u9014\u5f84\u4ee3\u8c22\u7684\u836f\u7269\u5b58\u5728\u76f8\u4e92\u4f5c\u7528\uff08<span>CYP3A4<\/span>\u6291\u5236\u5242<span>\/<\/span>\u8bf1\u5bfc\u5242\uff09\uff1a\u5982\u4e0e\u916e\u5eb7\u5511\u8054\u7528\u53ef\u80fd\u4f1a\u63d0\u9ad8\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u7684\u53d1\u751f\u7387\uff1b\u5229\u798f\u5e73\u5bf9\u7ef4\u5e03\u59a5\u6614\u5355\u6297\u7684\u8840\u6d46\u66b4\u9732\u91cf\u6ca1\u6709\u5f71\u54cd\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u6bd2\u6027\u589e\u52a0\uff1a\u4e3b\u8981\u662f\u5176\u5171\u4ef7\u8026\u8fde\u7684\u5fae\u7ba1\u6291\u5236\u5242\u5355\u7532\u57fa\u6fb3\u745e\u4ed6\u6c40<span>E<\/span>\u96c6\u805a\u5f15\u8d77\uff0c\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\uff08\u808c\u9150\u6e05\u9664\u7387<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1c<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">30ml\/min<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff09\u60a3\u8005\u907f\u514d\u4f7f\u7528\u7ef4\u5e03\u59a5\u6614\u5355\u6297\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7f8e\u56fd<span>FDA<\/span>\u83b7\u6279\u7684\u5176\u4ed6\u9002\u5e94\u8bc1\uff1a\u5148\u524d\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6cbb\u7597\u7684\u539f\u53d1\u6027\u76ae\u80a4\u95f4\u53d8\u6027\u5927\u7ec6\u80de\u6dcb\u5df4\u7624\u6216<span>CD30<\/span>\u9633\u6027\u8548\u6837\u771f\u83cc\u75c5\u6210\u4eba\u60a3\u8005\uff1b\u8054\u5408\u5316\u7597\u6cbb\u7597\u521d\u6cbb<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2162\u6216<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2163<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u671f\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3001\u521d\u6cbb\u7cfb\u7edf\u6027\u95f4\u53d8\u6027\u5927\u7ec6\u80de\u6dcb\u5df4\u7624\u6216\u5176\u4ed6\u8868\u8fbe<span>CD30<\/span>\u7684\u5916\u5468<span>T<\/span>\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u3001\u897f\u8fbe\u672c\u80fa<span> Chidamide<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>5mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u7528\u4e8e\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u6b21\u5168\u8eab\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u7684\u5916\u5468<span>T<\/span>\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6210\u4eba\u63a8\u8350\u6bcf\u6b21\u670d\u836f<span>30mg<\/span>\uff0c\u6bcf\u5468\u670d\u836f\u4e24\u6b21\uff0c\u4e24\u6b21\u670d\u836f\u95f4\u9694\u4e0d\u5e94\u5c11\u4e8e<span>3<\/span>\u5929\uff08\u5982\u5468\u4e00\u548c\u5468\u56db\u3001\u5468\u4e8c\u548c\u5468\u4e94\u3001\u5468\u4e09\u548c\u5468\u516d\u7b49\uff09\uff0c\u65e9\u9910\u540e<span>30<\/span>\u5206\u949f\u670d\u7528\u3002\u82e5\u75c5\u60c5\u672a\u8fdb\u5c55\u6216\u672a\u51fa\u73b0\u4e0d\u80fd\u8010\u53d7\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5efa\u8bae\u6301\u7eed\u670d\u836f\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u8c03\u6574\uff1a<span>3<\/span>\u7ea7\u6216<span>4<\/span>\u7ea7\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\uff08\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\uff1c<span>1<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff09\u3001\u8840\u5c0f\u677f\u51cf\u5c11\uff08\u8840\u5c0f\u677f\u8ba1\u6570\uff1c<span>50<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff09\u3001\u8d2b\u8840\uff08\u8840\u7ea2\u86cb\u767d\u964d\u4f4e\u81f3\uff1c<span>80g\/L<\/span>\uff09\u65f6\uff0c\u6682\u505c\u7528\u836f\u3002\u5f85\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u503c\u6062\u590d\u81f3\u2265<span>1.5<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u3001\u8840\u5c0f\u677f\u6062\u590d\u81f3\u2265<span>75<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u3001\u8840\u7ea2\u86cb\u767d\u6062\u590d\u81f3\u2265<span>90g\/L<\/span>\uff0c\u5e76\u7ecf\u8fde\u7eed\u4e24\u6b21\u68c0\u67e5\u786e\u8ba4\uff0c\u53ef\u7ee7\u7eed\u6cbb\u7597\u3002\u5982\u4e4b\u524d\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a<span>3<\/span>\u7ea7\uff0c\u6062\u590d\u7528\u836f\u65f6\u53ef\u91c7\u7528\u539f\u5242\u91cf\u6216\u5242\u91cf\u964d\u4f4e\u81f3<span>20mg\/<\/span>\u6b21\uff1b\u5982\u4e4b\u524d\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a<span>4<\/span>\u7ea7\uff0c\u6062\u590d\u7528\u836f\u65f6\u5242\u91cf\u5e94\u964d\u4f4e\u81f3<span>20mg\/<\/span>\u6b21\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u6709\uff1a\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u8840\u5c0f\u677f\u8ba1\u6570\u51cf\u5c11\u3001\u767d\u7ec6\u80de\u6216\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u51cf\u5c11\u3001\u8840\u7ea2\u86cb\u767d\u964d\u4f4e\uff1b\u5168\u8eab\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u4e4f\u529b\u3001\u53d1\u70ed\uff1b\u80c3\u80a0\u9053\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u8179\u6cfb\u3001\u6076\u5fc3\u548c\u5455\u5410\uff1b\u4ee3\u8c22\u53ca\u8425\u517b\u7cfb\u7edf\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u98df\u6b32\u4e0b\u964d\u3001\u4f4e\u94be\u8840\u75c7\u548c\u4f4e\u9499\u8840\u75c7\uff1b\u4ee5\u53ca\u5934\u6655\u3001\u76ae\u75b9\u7b49\uff1b\u6781\u5c11\u6570\u60a3\u8005\u5fc3\u7535\u56fe\u4f1a\u51fa\u73b0<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">QTc<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u95f4\u671f\u5ef6\u957f\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u598a\u5a20\u671f\u5973\u6027\u60a3\u8005\u3001\u4e25\u91cd\u5fc3\u529f\u80fd\u4e0d\u5168\u60a3\u8005\uff08<span>NYHA<\/span>\u5fc3\u529f\u80fd\u4e0d\u5168\u5206\u7ea7\u2163\u7ea7\uff09\u7981\u7528\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e00\u3001\u787c\u66ff\u4f50\u7c73<span> Bortezomib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u5242\uff1a<span>1mg<\/span>\u3001<span>3.5mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u590d\u53d1\u6216\u96be\u6cbb\u6027\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u6216\u65e2\u5f80\u672a\u7ecf\u6cbb\u7597\u7684\u4e14\u4e0d\u9002\u5408\u63a5\u53d7\u9020\u8840\u5e72\u7ec6\u80de\u6818\u690d\u7684\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u6210\u4eba\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u521d\u6cbb\u53ca\u590d\u53d1\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3002<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u5e94\u8003\u8651\u6297\u75c5\u6bd2\u836f\u7269\u7684\u9884\u9632\u6cbb\u7597\uff0c\u964d\u4f4e\u5e26\u72b6\u75b1\u75b9\u518d\u6fc0\u6d3b\u7684\u98ce\u9669\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u542b\u6709\u7518\u9732\u9187\uff0c\u5728\u60a3\u8005\u521d\u6b21\u8bd5\u7528\u836f\u7269\u65f6\uff0c\u9700\u8981\u8be2\u95ee\u8fc7\u654f\u53f2\u53ca\u65e2\u5f80\u75c5\u53f2\uff0c\u8b66\u60d5\u9ad8\u80bf\u7624\u8d1f\u8377\u60a3\u8005\u53d1\u751f\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8ba1\u7b97\u7ed9\u836f\u4f53\u79ef\u9700\u4ed4\u7ec6\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u836f\u7269\u5177\u6709\u7ec6\u80de\u6bd2\u6027\uff0c\u914d\u5236\u65f6\u9700\u8981\u6234\u624b\u5957\u548c\u9632\u62a4\u7528\u54c1\uff0c\u907f\u514d\u76ae\u80a4\u76f4\u63a5\u63a5\u89e6\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4f7f\u7528\u65e0\u9700\u51cf\u91cf\uff0c\u8fdb\u884c\u900f\u6790\u7684\u60a3\u8005\u5e94\u5728\u900f\u6790\u540e\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u795e\u7ecf\u7cfb\u7edf\u75c7\u72b6\uff08\u5305\u62ec\u80a0\u6897\u963b\uff09\u3001\u75c5\u6bd2\u6fc0\u6d3b\u3001\u8840\u6db2\u7cfb\u7edf\u9aa8\u9ad3\u6291\u5236\u7b49\uff0c\u5c11\u89c1\u60c5\u51b5\u8fd8\u53ef\u4ee5\u51fa\u73b0\u6025\u6027\u80ba\u635f\u4f24\u3001\u80f0\u817a\u708e\u7b49\u3002<b><span><\/span><\/b><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u63a8\u8350\u8054\u7528\u5f3a\u6548\u7684<span>CYP3A4<\/span>\u6291\u5236\u5242\u3002\u5982\u679c\u65e0\u6cd5\u907f\u514d\u5408\u5e76\u7528\u836f\uff0c\u5219\u5e94\u5bf9\u6bd2\u6027\u53cd\u5e94\u8fdb\u884c\u5bc6\u5207\u76d1\u6d4b\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u787c\u66ff\u4f50\u7c73\u76ae\u4e0b\u6ce8\u5c04\u5177\u6709\u4e0e\u9759\u8109\u63a8\u6ce8\u540c\u6837\u7684\u7597\u6548\uff0c\u4e14\u795e\u7ecf\u75c5\u53d8\u53d1\u751f\u7387\u66f4\u4f4e\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u9700\u8981\u5177\u6709\u6cbb\u7597\u6307\u5f81\uff0c\u5373\u4ee5\u4e0b\u5176\u4e2d\u4e4b\u4e00\uff1a\u80be\u529f\u80fd\u5f02\u5e38\u3001\u8840\u9499\u5347\u9ad8\u3001\u8d2b\u8840\u53ca\u9aa8\u8d28\u7834\u574f\u3001\u8840\u6e05\u6e38\u79bb\u8f7b\u94fe\u6bd4\u503c\u5927\u4e8e<span>100<\/span>\u3001\u9aa8\u9ad3\u4e2d\u514b\u9686\u6d46\u7ec6\u80de\u5927\u4e8e<span>60%<\/span>\u3001\u6838\u78c1\u8bc1\u5b9e<span>2<\/span>\u5904\u6216\u4ee5\u4e0a\u9aa8\u8d28\u7834\u574f\u624d\u9700\u8981\u6cbb\u7597\u3002\u4e0d\u7b26\u5408\u4ee5\u4e0a\u6807\u51c6\u7684\u5192\u70df\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u76ee\u524d\u4e0d\u5efa\u8bae\u8fdb\u884c\u6cbb\u7597\uff0c\u5305\u62ec\u787c\u66ff\u4f50\u7c73\u7684\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u787c\u66ff\u4f50\u7c73\u5e94\u7528\u4e8e\u521d\u6cbb\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08<span>FDA<\/span>\u5df2\u83b7\u6279\uff0c\u57fa\u4e8e<span>LYM-3002<\/span>\u7814\u7a76\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08<span>FDA<\/span>\u5df2\u6279\u51c6\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">12.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5176\u4ed6\u7f55\u89c1\u6d46\u7ec6\u80de\u75c5\uff0c\u5982\u8f7b\u94fe\u6dc0\u7c89\u6837\u53d8\u6027\u3001<span>POEMS<\/span>\uff08\u4ec5\u2160\uff5e\u2161\u671f\u6570\u636e\uff09\u3001<span>MGRS<\/span>\uff08\u610f\u4e49\u672a\u660e\u5355\u514b\u9686\u514d\u75ab\u7403\u86cb\u767d\u8840\u75c7\u4f34\u80be\u810f\u635f\u4f24\uff0c\u4ec5\u6709\u2160\uff5e\u2161\u671f\u6570\u636e\uff09\u7b49\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5341\u4e8c\u3001\u4fe1\u8fea\u5229\u5355\u6297<span> Sintilimab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u9002\u7528\u4e8e\u81f3\u5c11\u7ecf\u8fc7\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u8bca\u65ad\u4e3a\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5e94\u8be5\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\u8bc4\u4f30\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u53cd\u5e94\u53ca\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u91c7\u7528\u9759\u8109\u8f93\u6ce8\u7684\u65b9\u5f0f\u7ed9\u836f\uff0c\u9759\u8109\u8f93\u6ce8\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>200mg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5982\u51fa\u73b0\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\u3002\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<b><span><\/span><\/b><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u672c\u54c1\u5c1a\u65e0\u9488\u5bf9\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\uff1b\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u672c\u54c1\u5c1a\u65e0\u9488\u5bf9\u4e2d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u8f7b\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\uff1b\u4e2d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u7684\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u2265<span>10%<\/span>\uff09\u5305\u62ec\u53d1\u70ed\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u75c7\u3001\u4f53\u91cd\u589e\u52a0\u3001\u80ba\u708e\u3001\u4e0a\u547c\u5438\u9053\u611f\u67d3\u3001\u76ae\u75b9\u3001\u8d2b\u8840\u3001\u54b3\u55fd\u3002\u6700\u5e38\u89c1\u7684<span>3<\/span>\u7ea7\u4ee5\u4e0a\u7684\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u4f53\u91cd\u589e\u52a0\u3001\u8d2b\u8840\u3001\u8f93\u6db2\u53cd\u5e94\u3001\u547c\u5438\u9053\u611f\u67d3\u3001\u611f\u67d3\u6027\u80ba\u708e\u3001\u514d\u75ab\u76f8\u5173\u6027\u80ba\u708e\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5c1a\u65e0<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u53ca\u9752\u5c11\u5e74\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5728\u2265<span>65<\/span>\u5c81\u7684\u8001\u5e74\u60a3\u8005\u4e2d\u5e94\u7528\u6570\u636e\u6709\u9650\uff0c\u5efa\u8bae\u5728\u533b\u751f\u7684\u6307\u5bfc\u4e0b\u614e\u7528\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e0d\u5efa\u8bae\u5728\u598a\u5a20\u671f\u95f4\u4f7f\u7528\u672c\u54c1\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">12.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u56e0\u53ef\u80fd\u5e72\u6270\u672c\u54c1\u836f\u6548\u5b66\u6d3b\u6027\uff0c\u5e94\u907f\u514d\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002\u4f46\u662f\u5982\u679c\u4e3a\u4e86\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u540e\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e09\u3001\u5361\u745e\u5229\u73e0\u5355\u6297<span> Camrelizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7c89\u9488\u5242\uff1a<span>200mg\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u9002\u7528\u4e8e\u81f3\u5c11\u7ecf\u8fc7\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u8bca\u65ad\u4e3a\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u8be5\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\u8bc4\u4f30\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u53cd\u5e94\u53ca\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u91c7\u7528\u9759\u8109\u8f93\u6ce8\u7684\u65b9\u5f0f\u7ed9\u836f\uff0c\u9759\u8109\u8f93\u6ce8\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>200mg<\/span>\uff0c\u6bcf<span>2<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u51fa\u73b0\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\u3002\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u672c\u54c1\u5c1a\u65e0\u9488\u5bf9\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u672c\u54c1\u5c1a\u65e0\u9488\u5bf9\u4e2d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u4e2d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002\u8f7b\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a5\u53d7\u672c\u836f\u6cbb\u7597\u7684\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u2265<span>10%<\/span>\uff09\u5305\u62ec\u76ae\u80a4\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u3001\u53d1\u70ed\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u3001\u4e0a\u547c\u5438\u9053\u611f\u67d3\u3001\u8d2b\u8840\u3001\u8f93\u6db2\u76f8\u5173\u53cd\u5e94\u3001\u54b3\u55fd\u3001\u53e3\u8154\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u3001\u9f3b\u54bd\u708e\u3001\u7619\u75d2\u75c7\u3002\u6700\u5e38\u89c1\u7684<span>3<\/span>\u7ea7\u4ee5\u4e0a\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u2265<span>2%<\/span>\uff09\u5305\u62ec\u6dcb\u5df4\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u3001\u767d\u7ec6\u80de\u8ba1\u6570\u51cf\u5c11\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u3001\u03b3<span>&#8211;<\/span>\u8c37\u6c28\u9170\u8f6c\u79fb\u9176\u5347\u9ad8\u3001\u5e26\u72b6\u75b1\u75b9\u3001\u80ba\u90e8\u708e\u75c7\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5c1a\u65e0<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u53ca\u9752\u5c11\u5e74\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5728\u2265<span>65<\/span>\u5c81\u7684\u8001\u5e74\u60a3\u8005\u4e2d\u5e94\u7528\u6570\u636e\u6709\u9650\uff0c\u5efa\u8bae\u5728\u533b\u751f\u7684\u6307\u5bfc\u4e0b\u614e\u7528\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u5efa\u8bae\u5728\u598a\u5a20\u671f\u95f4\u4f7f\u7528\u672c\u54c1\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">12.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56e0\u53ef\u80fd\u5e72\u6270\u672c\u54c1\u836f\u6548\u5b66\u6d3b\u6027\uff0c\u5e94\u907f\u514d\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002\u4f46\u662f\u5982\u679c\u4e3a\u4e86\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u540e\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">13.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u7684\u5904\u7406\uff1a\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u53ef\u6709\u7ea6<span>70%<\/span>\u53d1\u751f\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u3002\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\uff0c\u5927\u591a\u53d1\u751f\u5728\u4f53\u8868\u76ae\u80a4\uff0c\u5c11\u6570\u53ef\u89c1\u4e8e\u53e3\u8154\u9ecf\u819c\u3001\u9f3b\u8154\u9ecf\u819c\u4ee5\u53ca\u773c\u7751\u7ed3\u819c\u3002\u53d1\u751f\u4e8e\u76ae\u80a4\u7684\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\uff0c\u521d\u59cb\u591a\u8868\u73b0\u4e3a\u4f53\u8868\u9c9c\u7ea2\u8272\u70b9\u72b6\u7269\uff0c\u76f4\u5f84\u2264<span>2mm<\/span>\uff0c\u968f\u7740\u7528\u836f\u6b21\u6570\u589e\u52a0\uff0c\u75c5\u53d8\u8303\u56f4\u53ef\u9010\u6e10\u589e\u5927\uff0c\u591a\u4e3a\u7ed3\u8282\u72b6\uff0c\u4e5f\u6709\u6591\u7247\u72b6\uff0c\u989c\u8272\u9c9c\u7ea2\u6216\u6697\u7ea2\uff0c\u9700\u89c2\u5bdf\u4e34\u5e8a\u75c7\u72b6\u548c\u4f53\u5f81\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5f53\u60a3\u8005\u51fa\u73b0\u8be5\u4e0d\u826f\u53cd\u5e94\u65f6\uff0c\u5e94\u907f\u514d\u6293\u6320\u6216\u6469\u64e6\uff0c\u6613\u6469\u64e6\u90e8\u4f4d\u53ef\u7528\u7eb1\u5e03\u4fdd\u62a4\u4ee5\u907f\u514d\u51fa\u8840\uff0c\u540c\u65f6\u5e94\u8054\u7cfb\u4e3b\u7ba1\u533b\u751f\uff0c\u83b7\u5f97\u6070\u5f53\u7684\u5904\u7406\u5efa\u8bae\u3002\u7834\u6e83\u51fa\u8840\u8005\u53ef\u91c7\u7528\u5c40\u90e8\u538b\u8feb\u6b62\u8840\uff0c\u6216\u91c7\u53d6\u5982\u6fc0\u5149\u6216\u624b\u672f\u5207\u9664\u7b49\u5c40\u90e8\u6cbb\u7597\uff1b\u5e76\u53d1\u611f\u67d3\u8005\u5e94\u7ed9\u4e88\u6297\u611f\u67d3\u6cbb\u7597\u3002\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u53ef\u80fd\u5728\u76ae\u80a4\u4ee5\u5916\u7684\u5176\u4ed6\u7ec4\u7ec7\u53d1\u751f\uff08\u5305\u62ec\u5185\u810f\u5668\u5b98\uff09\uff0c\u5fc5\u8981\u65f6\u8fdb\u884c\u76f8\u5e94\u7684\u533b\u5b66\u68c0\u67e5\uff0c\u5982\u5927\u4fbf\u6f5c\u8840\u3001\u5185\u7aa5\u955c\u53ca\u5f71\u50cf\u5b66\u68c0\u67e5\uff08\u5177\u4f53\u76f8\u5173\u5185\u5bb9\u8be6\u89c1\u300a\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u4fe1\u606f\u6536\u96c6\u53ca\u98ce\u9669\u7ba1\u7406\u8ba1\u5212\u300b\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u56db\u3001\u66ff\u96f7\u5229\u73e0\u5355\u6297<span>Tislelizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u81f3\u5c11\u7ecf\u8fc7\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u8be5\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\u8bc4\u4f30\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u53cd\u5e94\u53ca\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u91c7\u7528\u9759\u8109\u8f93\u6ce8\u7684\u65b9\u5f0f\u7ed9\u836f\uff0c\u9759\u8109\u8f93\u6ce8\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>200mg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\uff0c\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\u3002\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u5c1a\u65e0\u9488\u5bf9\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u5c1a\u65e0\u9488\u5bf9\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u54fa\u4e73\u671f\u5987\u5973\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u53ca\u672b\u6b21\u7ed9\u836f\u540e\u81f3\u5c11<span>5<\/span>\u4e2a\u6708\u5185\u505c\u6b62\u54fa\u4e73\u3002\u80b2\u9f84\u671f\u5987\u5973\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u671f\u95f4\uff0c\u4ee5\u53ca\u6700\u540e\u4e00\u6b21\u672c\u54c1\u7ed9\u836f\u540e\u81f3\u5c11<span>5<\/span>\u4e2a\u6708\u5185\u5e94\u91c7\u7528\u6709\u6548\u907f\u5b55\u63aa\u65bd\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56e0\u53ef\u80fd\u5e72\u6270\u672c\u54c1\u836f\u6548\u5b66\u6d3b\u6027\uff0c\u5e94\u907f\u514d\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002\u4f46\u662f\u5982\u679c\u4e3a\u4e86\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u540e\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5176\u4ed6\uff1a\u5355\u836f\u6cbb\u7597\u590d\u53d1\u96be\u6cbb\u7ed3\u5916<span>NK\/T<\/span>\u7ec6\u80de\u6dcb\u5df4\u7624\uff08\u4ec5\u6709\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff09\u3002\u5355\u836f\u6cbb\u7597\u590d\u53d1\u96be\u6cbb\u5916\u5468<span>T<\/span>\u7ec6\u80de\u6dcb\u5df4\u7624\uff08\u4ec5\u6709\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e94\u3001\u6cfd\u5e03\u66ff\u5c3c <span>Zanubrutinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>80mg<\/span><\/span><b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u4eba\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08<span>MCL<\/span>\uff09\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u4eba\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08<span>CLL<\/span>\uff09<span>\/<\/span>\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08<span>SLL<\/span>\uff09\u60a3\u8005\u3002<\/span><b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cfd\u5e03\u66ff\u5c3c\u7528\u4e8e<span>CLL<\/span>\u6cbb\u7597\u524d\uff0c\u5e94\u8fdb\u884c\u4e25\u683c\u4e34\u5e8a\u8bc4\u4f30\uff0c\u5982\u679c\u60a3\u8005\u6709\u660e\u786e<span>del<\/span>\uff08<span>17p<\/span>\uff09\uff0c\u9009<span>BTK<\/span>\u6291\u5236\u5242\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u8be5\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\u8bc4\u4f30\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u53cd\u5e94\u53ca\u6bd2\u6027\uff0c\u6ce8\u610f\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\uff08\u5c24\u5176\u5728<span>CLL<\/span>\u60a3\u8005\u4e2d\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597<span>MCL<\/span>\u4e0e<span>CLL\/SLL<\/span>\u7684\u63a8\u8350\u5242\u91cf\u5747\u4e3a<span>160mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff08<span>Child-Pugh A<\/span>\u7ea7\u548c<span>B<\/span>\u7ea7\uff09\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff08<span>Child-Pugh B<\/span>\u7ea7\u548c<span>C<\/span>\u7ea7\uff09\u7684\u63a8\u8350\u5242\u91cf\u662f<span>80mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53e3\u670d\u7ed9\u836f\uff0c\u6bcf\u5929\u7684\u7528\u836f\u65f6\u95f4\u5927\u81f4\u56fa\u5b9a\u3002\u5e94\u7528\u6c34\u9001\u670d\u6574\u7c92\u80f6\u56ca\uff0c\u53ef\u5728\u996d\u524d\u6216\u996d\u540e\u670d\u7528\u3002\u7981\u6b62\u6253\u5f00\u3001\u5f04\u7834\u6216\u5480\u56bc\u80f6\u56ca\u3002\u5982\u679c\u672a\u5728\u8ba1\u5212\u65f6\u95f4\u670d\u7528\u672c\u54c1\uff0c\u60a3\u8005\u5e94\u5728\u76f8\u90bb\u670d\u836f\u95f4\u9694\u81f3\u5c11<span>8<\/span>\u5c0f\u65f6\u57fa\u7840\u4e0a\u5c3d\u5feb\u670d\u7528\uff0c\u5e76\u5728\u540e\u7eed\u6062\u590d\u6b63\u5e38\u7528\u836f\u8ba1\u5212\u3002\u8bf7\u52ff\u989d\u5916\u670d\u7528\u672c\u54c1\u4ee5\u5f25\u8865\u6f0f\u670d\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7c92\u7ec6\u80de\u51cf\u5c11\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u3001\u8d2b\u8840\u662f\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u3002\u7528\u836f\u671f\u95f4\u9700\u8981\u76d1\u6d4b\u8840\u5e38\u89c4\u3002\u51fa\u73b0<span>3<\/span>\u7ea7\u8840\u6db2\u5b66\u6bd2\u6027\u53ca\u4ee5\u4e0a\u6ce8\u610f\u5242\u91cf\u8c03\u6574\u3002<span>\u22653<\/span>\u7ea7\u4f34\u611f\u67d3\u6216\u53d1\u70ed\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u6216\u8005<span>4<\/span>\u7ea7\u8840\u6db2\u5b66\u6bd2\u6027\u65f6\uff0c\u5e94\u4e2d\u65ad\u6cbb\u7597\uff0c\u5f85\u6bd2\u6027\u75c7\u72b6\u6d88\u9000\u81f3<span>1<\/span>\u7ea7\u6216\u57fa\u7ebf\u6c34\u5e73\uff08\u6062\u590d\uff09\u65f6\uff0c\u53ef\u4ee5\u8d77\u59cb\u5242\u91cf\u91cd\u65b0\u5f00\u59cb\u6cbb\u7597\u3002\u5982\u679c\u8be5\u6bd2\u6027\u518d\u6b21\u53d1\u751f\uff0c\u5e94\u518d\u6b21\u4e2d\u65ad\u6cbb\u7597\uff0c\u5f85\u6bd2\u6027\u75c7\u72b6\u6d88\u9000\u81f3<span>1<\/span>\u7ea7\u6216\u57fa\u7ebf\u6c34\u5e73\uff08\u6062\u590d\uff09\u65f6\u4ee5<span>80mg<\/span><\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\/<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\u7684\u5242\u91cf\u91cd\u65b0\u5f00\u59cb\u7528\u836f\u3002\u5982\u679c\u5728\u5242\u91cf\u964d\u4f4e\u540e\u8be5\u6bd2\u6027\u7b2c\u4e09\u6b21\u53d1\u751f\uff0c\u5e94\u518d\u6b21\u4e2d\u65ad\u6cbb\u7597\uff0c\u5f85\u6bd2\u6027\u75c7\u72b6\u6d88\u9000\u81f3<span>1<\/span>\u7ea7\u6216\u57fa\u7ebf\u6c34\u5e73\uff08\u6062\u590d\uff09\u65f6\u4ee5<span>80mg<\/span><span>\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e00\u6b21\u7684\u5242\u91cf\u91cd\u65b0\u5f00\u59cb\u7528\u836f\u3002\u5982\u679c\u5728\u4e24\u6b21\u5242\u91cf\u964d\u4f4e\u540e\u8be5\u6bd2\u6027\u7b2c\u56db\u6b21\u53d1\u751f\uff0c\u5e94\u7ec8\u6b62\u672c\u54c1\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0e<span>CYP3A<\/span>\u6291\u5236\u5242\u6216\u8bf1\u5bfc\u5242\u8054\u5408\u7ed9\u836f\u65f6\u7684\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8868<span>4<\/span>&emsp;\u4e0e<span>CYP3A<\/span>\u6291\u5236\u5242\u6216\u8bf1\u5bfc\u5242\u8054\u5408\u7ed9\u836f\u65f6\u7684\u5242\u91cf\u8c03\u6574<span><\/span><\/span><\/b>\n<\/p>\n<table class=\"MsoNormalTable\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"1148\" style=\"width:430.65pt;border-collapse:collapse;border:none;\">\n<tbody>\n<tr>\n<td width=\"411\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8054\u5408\u7ed9\u836f<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"737\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u8c03\u6574\u5efa\u8bae<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"411\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5f3a\u6548<span>CYP3A<\/span>\u6291\u5236\u5242<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"737\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">80mg\/<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b21\uff0c\u6bcf\u5929\u4e00\u6b21<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51fa\u73b0\u4e0d\u826f\u53cd\u5e94\u65f6\u6839\u636e\u5242\u91cf\u8c03\u6574\u5efa\u8bae\u4e2d\u65ad\u7ed9\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"411\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e2d\u6548<span>CYP3A<\/span>\u6291\u5236\u5242<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"737\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">80mg\/<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51fa\u73b0\u4e0d\u826f\u53cd\u5e94\u65f6\u518d\u6b21\u5242\u91cf\u8c03\u6574<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"411\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5f3a\u6548\u6216\u4e2d\u6548<span>CYP3A<\/span>\u8bf1\u5bfc\u5242<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"737\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u540c\u65f6\u4f7f\u7528<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e59\u809d\u75c5\u6bd2\u518d\u6fc0\u6d3b\u7684\u98ce\u9669\uff1a\u4f7f\u7528\u6cfd\u5e03\u66ff\u5c3c\u8fc7\u7a0b\u4e2d\u9700\u8981\u6ce8\u610f\u4e59\u809d\u75c5\u6bd2\u6fc0\u6d3b\u7684\u98ce\u9669\u3002\u5e94\u5728\u4f7f\u7528\u524d\u660e\u786e\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u72b6\u6001\uff0c\u5bf9\u4e8e\u76ee\u524d\u6216\u65e2\u5f80\u6709\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u611f\u67d3\u7684\u60a3\u8005\uff0c\u5728\u5f00\u59cb\u6cbb\u7597\u524d\u9700\u8981\u54a8\u8be2\u809d\u708e\u4e13\u79d1\u533b\u5e08\uff0c\u5e76\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u6ce8\u610f\u76d1\u6d4b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u5efa\u8bae\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\uff08\u808c\u9150\u6e05\u9664\u7387\uff1c<span>30ml\/min<\/span>\uff09\u6216\u900f\u6790\u60a3\u8005\u4f7f\u7528\u672c\u54c1\u9700\u8981\u6ce8\u610f\u76d1\u6d4b\u4e0d\u826f\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5176\u4ed6\u9002\u5e94\u8bc1\uff1a\u4e00\u7ebf\u6cbb\u7597\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5<span>\/<\/span>\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08\u57fa\u4e8e\u5168\u7403\u591a\u4e2d\u5fc3\u2161\u671f\u4e34\u5e8a\u7814\u7a76<span>AU003<\/span>\u7684\u6570\u636e\uff0c\u4ee5\u53ca\u5168\u7403\u591a\u4e2d\u5fc3\u2162\u671f\u4e34\u5e8a\u7814\u7a76<span>SEQUOIA<\/span>\u7814\u7a76\u4e2d<span>17p-<\/span>\u4e9a\u7ec4\u7684\u6570\u636e\uff09\uff0c\u521d\u6cbb\u53ca\u590d\u53d1\u7684\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\u6dcb\u5df4\u7624\uff08\u2162\u671f\u4e34\u5e8a\u7814\u7a76\uff09\u3002\u590d\u53d1<span>\/<\/span>\u96be\u6cbb\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624\uff08\u4ec5\u6709\u2160\uff5e\u2161\u671f\u4e34\u5e8a\u7814\u7a76\uff09\uff0c\u590d\u53d1<span>\/<\/span>\u96be\u6cbb\u6ee4\u6ce1\u578b\u6dcb\u5df4\u7624\uff08\u4ec5\u6709\u2160\uff5e\u2161\u671f\u4e34\u5e8a\u7814\u7a76\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u516d\u3001\u6765\u90a3\u5ea6\u80fa<span> Lenalidomide<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10mg<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u3001<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">25mg<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u521d\u6cbb\u53ca\u590d\u53d1\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3002<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u836f\u7269\u5177\u6709\u9aa8\u9ad3\u6291\u5236\u4f5c\u7528\uff0c\u5e94\u7528\u540e\u9700\u8981\u76d1\u6d4b\u60a3\u8005\u8840\u5e38\u89c4\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u9002\u5408\u63a5\u6536\u81ea\u4f53\u5e72\u7ec6\u80de\u79fb\u690d\u7684\u75c5\u4eba\uff0c\u79fb\u690d\u524d\u5efa\u8bae\u63a5\u53d7\u4e0d\u8981\u8d85\u8fc7<span>4<\/span>\u4e2a\u7597\u7a0b\u542b\u6709\u6765\u90a3\u5ea6\u80fa\u7684\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u787c\u66ff\u4f50\u7c73\u4e0e\u6765\u90a3\u5ea6\u80fa\u5177\u6709\u534f\u540c\u4f5c\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80be\u529f\u80fd\u635f\u4f24\u7684\u9aa8\u9ad3\u7624\u60a3\u8005\u9700\u8981\u51cf\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u957f\u671f\u5e94\u7528\u4f1a\u589e\u52a0\u7b2c\u4e8c\u80bf\u7624\u7684\u98ce\u9669\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8840\u7ec6\u80de\u51cf\u5c11\u3001\u76ae\u75b9\u4e3a\u6765\u90a3\u5ea6\u80fa\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5176\u4f59\u5305\u62ec\u6df1\u9759\u8109\u8840\u6813\u3002<b><span><\/span><\/b><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u63a5\u53d7\u6765\u90a3\u5ea6\u80fa\u4e0e\u5730\u585e\u7c73\u677e\u8054\u5408\u6cbb\u7597\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\uff0c\u6df1\u9759\u8109\u8840\u6813\u548c\u80ba\u6813\u585e\u7684\u98ce\u9669\u663e\u8457\u5347\u9ad8\u3002\u9700\u8981\u5bc6\u5207\u6ce8\u610f\u8840\u6813\u5bfc\u81f4\u7684\u75c7\u72b6\u548c\u4f53\u5f81\uff0c\u5408\u5e76\u9ad8\u5371\u8840\u6813\u98ce\u9669\u65f6\u5efa\u8bae\u7ed9\u4e88\u9884\u9632\u6027\u6297\u51dd\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53ef\u80fd\u4f1a\u6709\u80da\u80ce<span>&#8211;<\/span>\u751f\u6b96\u6bd2\u6027\uff0c\u4f7f\u7528\u671f\u95f4\u6ce8\u610f\u907f\u5b55\u3002\u5bf9\u513f\u7ae5\u751f\u957f\u53d1\u80b2\u4f1a\u6709\u6f5c\u5728\u5f71\u54cd\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ee4\u6ce1\u7ec6\u80de\u6dcb\u5df4\u7624\uff08\u5168\u7403\u5176\u4ed6\u56fd\u5bb6\u5df2\u6279\u51c6\u7684\u9002\u5e94\u8bc1\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.POEMS<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7efc\u5408\u5f81\uff08\u4ec5\u6709\u2160\uff5e\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u94fe\u6dc0\u7c89\u6837\u53d8\u6027\uff08\u4ec5\u6709\u2160\uff5e\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">12.MGRS<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08\u4ec5\u6709\u2160\uff5e\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">13.del<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08<span>5q<\/span>\uff09\u7684<span>IPSS<\/span>\u8bc4\u5206\u4f4e\u5371<span>\/<\/span>\u4e2d\u5371<span>1<\/span>\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\uff08\u5168\u7403\u5176\u4ed6\u56fd\u5bb6\u5df2\u6279\u51c6\u7684\u9002\u5e94\u8bc1\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e03\u3001\u6cca\u9a6c\u5ea6\u80fa<span> Pomalidomide<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>1mg<\/span>\u3001<span>4mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u590d\u53d1\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff1a\u6cca\u9a6c\u5ea6\u80fa\u4e0e\u5730\u585e\u7c73\u677e\u8054\u7528\uff0c\u9002\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e24\u79cd\u6cbb\u7597\uff08\u5305\u62ec\u6765\u90a3\u5ea6\u80fa\u548c\u4e00\u79cd\u86cb\u767d\u9176\u4f53\u6291\u5236\u5242\uff09\uff0c\u4e14\u5728\u6700\u540e\u4e00\u6b21\u6cbb\u7597\u671f\u95f4\u6216\u6cbb\u7597\u7ed3\u675f\u540e<span>60<\/span>\u5929\u5185\u53d1\u751f\u75be\u75c5\u8fdb\u5c55\u7684\u6210\u5e74\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u836f\u7269\u5177\u6709\u9aa8\u9ad3\u6291\u5236\u4f5c\u7528\uff0c\u5e94\u7528\u540e\u9700\u8981\u76d1\u6d4b\u60a3\u8005\u8840\u5e38\u89c4\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u9002\u5408\u63a5\u53d7\u81ea\u4f53\u5e72\u7ec6\u80de\u79fb\u690d\u7684\u75c5\u4eba\uff0c\u79fb\u690d\u524d\u5efa\u8bae\u63a5\u53d7\u4e0d\u8981\u8d85\u8fc7<span>4<\/span>\u4e2a\u7597\u7a0b\u542b\u6709\u6cca\u9a6c\u5ea6\u80fa\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u787c\u66ff\u4f50\u7c73\u4e0e\u6cca\u9a6c\u5ea6\u80fa\u5177\u6709\u534f\u540c\u4f5c\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u9700\u8981\u900f\u6790\u7684\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u63a8\u8350\u7684\u8d77\u59cb\u5242\u91cf\u662f<span>3mg\/d<\/span>\uff08\u964d\u4f4e<span>25%<\/span>\uff09\u3002\u5728\u63a5\u53d7\u8840\u6db2\u900f\u6790\u7684\u5f53\u5929\uff0c\u5e94\u5728\u5b8c\u6210\u900f\u6790\u4e4b\u540e\u670d\u7528\u6cca\u9a6c\u5ea6\u80fa\u3002\u5176\u4ed6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u8f7b\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff08<span>Child-Pugh A<\/span>\u7ea7\u6216<span>B<\/span>\u7ea7\uff09\uff0c\u63a8\u8350\u8d77\u59cb\u5242\u91cf\u662f<span>3mg\/d<\/span>\uff08\u964d\u4f4e<span>25%<\/span>\uff09\u3002\u5bf9\u4e8e\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff08<span>Child-Pugh C<\/span>\u7ea7\uff09\uff0c\u63a8\u8350\u7ed9\u836f\u5242\u91cf\u662f<span>2mg<\/span>\uff08\u964d\u4f4e<span>50%<\/span>\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cca\u9a6c\u5ea6\u80fa\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\uff08\uff1e<span>30%<\/span>\uff09\u5305\u62ec\u75b2\u52b3\u4e4f\u529b\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u8d2b\u8840\u3001\u4fbf\u79d8\u3001\u6076\u5fc3\u3001\u8179\u6cfb\u3001\u547c\u5438\u56f0\u96be\u3001\u4e0a\u547c\u5438\u9053\u611f\u67d3\u3001\u80cc\u75db\u548c\u53d1\u70ed\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u63a5\u53d7\u6cca\u9a6c\u5ea6\u80fa\u6cbb\u7597\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\uff0c\u6cbb\u7597\u671f\u95f4\u6709\u53d1\u751f\u6df1\u9759\u8109\u8840\u6813\u548c\u80ba\u6813\u585e\u7684\u98ce\u9669\u3002\u5bf9\u4e8e\u6709\u5df2\u77e5\u98ce\u9669\u56e0\u7d20\uff08\u5305\u62ec\u8840\u6813\u53f2\uff09\u7684\u75c5\u4eba\uff0c\u53d1\u751f\u9759\u8109\u548c\u52a8\u8109\u8840\u6813\u6813\u585e\u4e8b\u4ef6\u7684\u98ce\u9669\u66f4\u9ad8\u3002\u63a8\u8350\u8fdb\u884c\u8840\u6813\u7684\u9884\u9632\u6cbb\u7597\uff0c\u5e94\u57fa\u4e8e\u5bf9\u60a3\u8005\u6f5c\u5728\u98ce\u9669\u56e0\u7d20\u7684\u8bc4\u4f30\u9009\u62e9\u6cbb\u7597\u65b9\u6848\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53ef\u80fd\u4f1a\u6709\u80da\u80ce<span>&#8211;<\/span>\u751f\u6b96\u6bd2\u6027\uff0c\u4f7f\u7528\u671f\u95f4\u987b\u6ce8\u610f\u907f\u5b55\uff0c\u65e0\u8bba\u7537\u5973\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0e\u5f3a\u6548<span> CYP1A2 <\/span>\u6291\u5236\u5242\u8054\u7528\uff08\u73af\u4e19\u6c99\u661f\u3001\u6c1f\u4f0f\u6c99\u660e\uff09\uff0c\u8003\u8651\u5176\u4ed6\u66ff\u4ee3\u7597\u6cd5\u3002\u5982\u65e0\u6cd5\u907f\u514d\u4e0e\u5f3a\u6548<span>CYP1A2 <\/span>\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\uff0c\u5219\u8d77\u59cb\u5242\u91cf\u5e94\u51cf\u5c11\u81f3<span>2mg<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5361\u6ce2\u897f\u8089\u7624\uff08\u7f8e\u56fd\u5df2\u6279\u51c6\u7684\u9002\u5e94\u8bc1\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cca\u9a6c\u5ea6\u80fa\u8054\u5408\u787c\u66ff\u4f50\u7c73\u4ee5\u53ca\u5730\u585e\u7c73\u677e\u6cbb\u7597\u590d\u53d1\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff1a\u6cca\u9a6c\u5ea6\u80fa\u4e0e\u787c\u66ff\u4f50\u7c73\u3001\u5730\u585e\u7c73\u677e\u8054\u7528\uff0c\u9002\u7528\u4e8e\u65e2\u5f80\u5df2\u63a5\u53d7\u81f3\u5c11\u4e00\u79cd\u6cbb\u7597\u65b9\u6848\uff08\u5305\u62ec\u6765\u90a3\u5ea6\u80fa\uff09\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u6210\u4eba\u60a3\u8005\uff08\u6b27\u6d32\u5df2\u6279\u51c6\u7684\u9002\u5e94\u8bc1\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">12.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u94fe\u6dc0\u7c89\u6837\u53d8\u6027\uff1a\u6709\u2160\uff5e\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff0c\u5e76\u88ab\u8f7b\u94fe\u6dc0\u7c89\u6837\u53d8\u6027<span>2021V2<\/span>\u7248<span>NCCN<\/span>\u6307\u5357\u63a8\u8350\uff08<span>2A<\/span>\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">13.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u539f\u53d1\u6027\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u6dcb\u5df4\u7624\uff1a\u6709\u2160\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff0c\u5e76\u88ab\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u6dcb\u5df4\u7624<span>2021V1<\/span>\u7248<span>NCCN<\/span>\u6307\u5357\u63a8\u8350\uff08<span>2A<\/span>\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u516b\u3001\u6c99\u5229\u5ea6\u80fa<span> Thalidomide<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08<span>1<\/span>\uff09\u7247\u5242\uff1a<span>25mg<\/span>\uff1b\uff08<span>2<\/span>\uff09\u80f6\u56ca\uff1a<span>25mg<\/span><\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7624\u578b\u9ebb\u98ce\u75c5\u3002<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c99\u5229\u5ea6\u80fa\u53ef\u4ee5\u5f15\u8d77\u5fc3\u7387\u51cf\u6162\uff0c\u4e25\u91cd\u8005\u51fa\u73b0\u4e09\u5ea6\u623f\u5ba4\u4f20\u5bfc\u963b\u6ede\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u672c\u54c1\u6709\u8fc7\u654f\u53cd\u5e94\u7684\u60a3\u8005\u614e\u7528\u3002\u6c99\u5229\u5ea6\u80fa\u5177\u6709\u81f4\u7578\u6027\uff0c\u5b55\u5987\u53ca\u54fa\u4e73\u671f\u5987\u5973\u3001\u513f\u7ae5\u7981\u7528\u3002\u5176\u4ed6\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u5fc3\u7387\u51cf\u6162\u3001\u76ae\u75b9\u3001\u4fbf\u79d8\u3001\u5468\u56f4\u795e\u7ecf\u75c5\u53d8\u3001\u55dc\u7761\u53ca\u6df1\u9759\u8109\u8840\u6813\u7b49\uff0c\u53ef\u901a\u8fc7\u51cf\u91cf\u4ee5\u53ca\u8f85\u52a9\u7528\u836f\u7f13\u89e3\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u787c\u66ff\u4f50\u7c73\u4e0e\u6c99\u5229\u5ea6\u80fa\u5177\u6709\u534f\u540c\u4f5c\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u63a5\u53d7\u6c99\u5229\u5ea6\u80fa\u4e0e\u5730\u585e\u7c73\u677e\u8054\u5408\u6cbb\u7597\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\uff0c\u6df1\u9759\u8109\u8840\u6813\u548c\u80ba\u6813\u585e\u7684\u98ce\u9669\u663e\u8457\u5347\u9ad8\u3002\u9700\u8981\u5bc6\u5207\u6ce8\u610f\u8840\u6813\u5bfc\u81f4\u7684\u75c7\u72b6\u548c\u4f53\u5f81\uff0c\u5408\u5e76\u9ad8\u5371\u8840\u6813\u98ce\u9669\u65f6\u5efa\u8bae\u7ed9\u4e88\u9884\u9632\u6027\u6297\u51dd\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ec6\u80de\u9057\u4f20\u5b66\u9ad8\u5371\u60a3\u8005\u4e0d\u5efa\u8bae\u5355\u72ec\u4f7f\u7528\u6c99\u5229\u5ea6\u80fa\u8fdb\u884c\u7ef4\u6301\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u670d\u7528\u540e\u4f1a\u51fa\u73b0\u55dc\u7761\uff0c\u7729\u6655\uff0c\u4e0d\u5efa\u8bae\u5f00\u8f66\uff0c\u5e94\u4e34\u7761\u524d\u670d\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c99\u5229\u5ea6\u80fa\u53ef\u4ee5\u7528\u4e8e\u521d\u6cbb\u53ca\u96be\u6cbb\u590d\u53d1\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u75c5\u4eba\uff08\u5728\u56fd\u5916\u5927\u591a\u6570\u56fd\u5bb6\u90fd\u5df2\u7ecf\u6279\u51c6\u7528\u4e8e\u521d\u6cbb\u4ee5\u53ca\u96be\u6cbb\u590d\u53d1\u9aa8\u9ad3\u7624\u6cbb\u7597\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5341\u4e5d\u3001\u4f0a\u6c99\u4f50\u7c73<span> Ixazomib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>2.3mg<\/span>\u3001<span>3mg<\/span>\u3001<span>4mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e0e\u6765\u90a3\u5ea6\u80fa\u548c\u5730\u585e\u7c73\u677e\u8054\u7528\uff0c\u6cbb\u7597\u5df2\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u79cd\u65e2\u5f80\u6cbb\u7597\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u6210\u4eba\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u7684\u7ed9\u836f\u9014\u5f84\u4e3a\u53e3\u670d\u3002\u60a3\u8005\u5e94\u8be5\u5728\u6bcf\u4e2a\u6cbb\u7597\u5468\u671f\u7b2c<span>1<\/span>\u3001<span>8<\/span>\u548c<span>15<\/span>\u5929\u5927\u81f4\u76f8\u540c\u7684\u65f6\u95f4\u670d\u836f\uff0c\u5728\u8fdb\u9910\u524d\u81f3\u5c11<span>1<\/span>\u5c0f\u65f6\u6216\u8fdb\u9910\u540e\u81f3\u5c11<span>2<\/span>\u5c0f\u65f6\u670d\u7528\u672c\u54c1\uff0c\u5e94\u7528\u6c34\u9001\u670d\u6574\u7c92\u80f6\u56ca\u3002\u8bf7\u52ff\u538b\u788e\u3001\u5480\u56bc\u6216\u6253\u5f00\u80f6\u56ca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5728\u5f00\u59cb\u4e00\u4e2a\u65b0\u7684\u6cbb\u7597\u5468\u671f\u524d\u5e94\u6ee1\u8db3\uff1a\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u8ba1\u6570\u5e94\u2265<span>1<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u3001\u8840\u5c0f\u677f\u8ba1\u6570\u5e94\u2265<span>75<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff0c\u975e\u8840\u6db2\u5b66\u6bd2\u6027\u4e00\u822c\u5e94\u6062\u590d\u81f3\u60a3\u8005\u7684\u57fa\u7ebf\u72b6\u51b5\u6216\u2264<span>1<\/span>\u7ea7\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u5e94\u6301\u7eed\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u7531\u4e8e<span>24<\/span>\u4e2a\u5468\u671f\u4e4b\u540e\u7684\u8010\u53d7\u6027\u548c\u6bd2\u6027\u76f8\u5173\u6570\u636e\u6709\u9650\uff0c\u56e0\u6b64\u5bf9\u4e8e\u9700\u8981\u957f\u4e8e<span>24<\/span>\u4e2a\u5468\u671f\u7684\u8054\u5408\u7ed9\u836f\u6cbb\u7597\uff0c\u5e94\u57fa\u4e8e\u60a3\u8005\u4e2a\u4f53\u83b7\u76ca\u98ce\u9669\u8bc4\u4f30\u7ed3\u679c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5982\u679c\u5ef6\u8bef\u6216\u6f0f\u670d\u4e00\u5242\u672c\u54c1\uff0c\u53ea\u6709\u5f53\u8ddd\u79bb\u4e0b\u6b21\u8ba1\u5212\u7ed9\u836f\u65f6\u95f4\u2265<span>72<\/span>\u5c0f\u65f6\uff0c\u65b9\u53ef\u8865\u670d\u6f0f\u670d\u5242\u91cf\u3002\u8ddd\u79bb\u5728\u4e0b\u6b21\u8ba1\u5212\u7ed9\u836f\u7684<span>72<\/span>\u5c0f\u65f6\u5185\u4e0d\u5f97\u8865\u670d\u6f0f\u670d\u5242\u91cf\u3002\u4e0d\u5f97\u670d\u7528\u53cc\u500d\u5242\u91cf\u4ee5\u5f25\u8865\u6f0f\u670d\u7684\u5242\u91cf\u3002\u5982\u679c\u60a3\u8005\u5728\u670d\u836f\u540e\u5455\u5410\uff0c\u4e0d\u5e94\u91cd\u590d\u670d\u836f\uff0c\u800c\u5e94\u5728\u4e0b\u6b21\u8ba1\u5212\u7ed9\u836f\u65f6\u6062\u590d\u7ed9\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u5e94\u8003\u8651\u6297\u75c5\u6bd2\u836f\u7269\u7684\u9884\u9632\u6cbb\u7597\uff0c\u964d\u4f4e\u5e26\u72b6\u75b1\u75b9\u75c5\u6bd2\u518d\u6fc0\u6d3b\u7684\u98ce\u9669\u3002\u5728\u4f0a\u6c99\u4f50\u7c73\u7814\u7a76\u4e2d\uff0c\u63a5\u53d7\u6297\u75c5\u6bd2\u836f\u7269\u9884\u9632\u6cbb\u7597\u60a3\u8005\u7684\u5e26\u72b6\u75b1\u75b9\u611f\u67d3\u53d1\u751f\u7387\u4f4e\u4e8e\u672a\u63a5\u53d7\u9884\u9632\u6cbb\u7597\u7684\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u4f0a\u6c99\u4f50\u7c73\u548c\u6765\u90a3\u5ea6\u80fa\u8840\u5c0f\u677f\u51cf\u5c11\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u548c\u76ae\u75b9\u7684\u91cd\u53e0\u6bd2\u6027\uff0c\u5efa\u8bae\u4ea4\u66ff\u8c03\u6574\u4f0a\u6c99\u4f50\u7c73\u548c\u6765\u90a3\u5ea6\u80fa\u7684\u5242\u91cf\u3002\u5bf9\u4e8e\u8fd9\u4e9b\u6bd2\u6027\uff0c\u5242\u91cf\u8c03\u6574\u7684\u7b2c\u4e00\u6b65\u662f\u505c\u7528<span>\/<\/span>\u51cf\u4f4e\u6765\u90a3\u5ea6\u80fa\u5242\u91cf\uff0c\u5173\u4e8e\u8fd9\u4e9b\u6bd2\u6027\u7684\u5242\u91cf\u51cf\u4f4e\u6b65\u9aa4\uff0c\u53c2\u89c1\u6765\u90a3\u5ea6\u80fa\u836f\u54c1\u8bf4\u660e\u4e66\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff08\u603b\u80c6\u7ea2\u7d20\u2264<span>ULN<\/span>\u548c<span>AST<\/span>\uff1e<span>ULN<\/span>\uff0c\u6216\u603b\u80c6\u7ea2\u7d20\uff1e<span>1<\/span>\uff5e<span>1.5<\/span>\u500d<span>ULN<\/span>\u548c<span>AST<\/span>\u4efb\u4f55\u6c34\u5e73\uff09\uff0c\u65e0\u9700\u8c03\u6574\u672c\u54c1\u7684\u5242\u91cf\u3002\u5bf9\u4e8e\u4e2d\u5ea6\uff08\u603b\u80c6\u7ea2\u7d20\uff1e<span>1.5<\/span>\uff5e<span>3<\/span>\u500d<span>ULN<\/span>\uff09\u6216\u91cd\u5ea6\uff08\u603b\u80c6\u7ea2\u7d20\uff1e<span>3<\/span>\u500d<span>ULN<\/span>\uff09\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u5efa\u8bae\u51cf\u91cf\u81f3<span>3mg<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff08\u808c\u9150\u6e05\u9664\u7387\u2265<span>30ml\/min<\/span>\uff09\uff0c\u65e0\u9700\u8c03\u6574\u672c\u54c1\u7684\u5242\u91cf\u3002\u5bf9\u4e8e\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\uff08\u808c\u9150\u6e05\u9664\u7387\uff1c<span>30ml\/min<\/span>\uff09\u6216\u9700\u900f\u6790\u7684\u7ec8\u672b\u671f\u80be\u75c5\u60a3\u8005\uff0c\u5efa\u8bae\u51cf\u91cf\u81f3<span>3mg<\/span>\u3002\u4f0a\u6c99\u4f50\u7c73\u4e0d\u80fd\u901a\u8fc7\u900f\u6790\u6e05\u9664\uff0c\u56e0\u6b64\u7ed9\u836f\u65f6\u53ef\u4ee5\u65e0\u9700\u8003\u8651\u900f\u6790\u65f6\u95f4\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u5e74\u9f84\u5927\u4e8e<span>65<\/span>\u5c81\u7684\u60a3\u8005\uff0c\u65e0\u9700\u8c03\u6574\u672c\u54c1\u7684\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u6c99\u4f50\u7c73\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\uff08\uff1e<span>20%<\/span>\uff09\u5305\u62ec\u8179\u6cfb\u3001\u4fbf\u79d8\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u3001\u5468\u56f4\u795e\u7ecf\u75c5\u53d8\u3001\u6076\u5fc3\u3001\u5916\u5468\u6c34\u80bf\u3001\u5455\u5410\u548c\u80cc\u75db\u3002\u5468\u56f4\u795e\u7ecf\u75c5\u53d8\u53d1\u751f\u7387\u4f4e\u4e8e\u787c\u66ff\u4f50\u7c73\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4f0a\u6c99\u4f50\u7c73\u548c<span>CYP3A<\/span>\u5f3a\u6548\u6291\u5236\u5242\u3001<span>CYP1A2<\/span>\u5f3a\u6548\u6291\u5236\u5242\u8054\u5408\u7ed9\u836f\u9700\u8981\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">12.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5f53\u4f0a\u6c99\u4f50\u7c73\u4e0e\u5730\u585e\u7c73\u677e\u8054\u5408\u7ed9\u836f\u65f6\uff0c\u9700\u8003\u8651\u53e3\u670d\u907f\u5b55\u836f\u7597\u6548\u964d\u4f4e\u7684\u98ce\u9669\u3002\u4f7f\u7528\u6fc0\u7d20\u907f\u5b55\u7684\u5973\u6027\u8fd8\u9700\u91c7\u7528\u5c4f\u969c\u907f\u5b55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">13.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65b0\u8bca\u65ad\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3001\u6dc0\u7c89\u6837\u53d8\u6027\u3001\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08\u4ec5\u6709<span>I<\/span>\uff5e\u2161\u671f\u4e34\u5e8a\u6570\u636e\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u3001\u8fbe\u96f7\u59a5\u5c24\u5355\u6297<span> Daratumumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>5ml<\/span>\uff09<span>\/<\/span>\u74f6\u3001<span>400mg<\/span>\uff08<span>20ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5355\u836f\u6cbb\u7597\u590d\u53d1\u548c\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u6210\u5e74\u60a3\u8005\uff0c\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u8fc7\u5305\u62ec\u86cb\u767d\u9176\u4f53\u6291\u5236\u5242\u548c\u514d\u75ab\u8c03\u8282\u5242\u7684\u6cbb\u7597\u4e14\u6700\u540e\u4e00\u6b21\u6cbb\u7597\u65f6\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5373\u523b\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\u7684\u5904\u7406\uff1a\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u662f\u4e00\u79cd\u751f\u7269\u5236\u5242\uff0c\u4f5c\u4e3a\u4e00\u79cd\u5916\u6e90\u6027\u86cb\u767d\u4e0e\u5176\u4ed6\u9776\u5411\u6027\u5355\u6297\u4e00\u6837\uff0c\u6709\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\uff08<span>IRR<\/span>\uff09\u3002<span>IRR<\/span>\u4e3b\u8981\u8868\u73b0\u4e3a\u9f3b\u585e\u3001\u54b3\u55fd\u3001\u54bd\u5589\u90e8\u523a\u6fc0\u611f\u3001\u5bd2\u6218\u3001\u6076\u5fc3\u548c\u5455\u5410\uff0c\u4e25\u91cd\u7684<span>IRR<\/span>\u8868\u73b0\u4e3a\u652f\u6c14\u7ba1\u75c9\u631b\uff0c\u547c\u5438\u56f0\u96be\uff0c\u5589\u5934\u6c34\u80bf\uff0c\u80ba\u6c34\u80bf\u548c\u9ad8\u8840\u538b\u3002\u6ce8\u5c04\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u65f6\u5e94\u4e25\u683c\u9075\u5b88\u89c4\u5b9a\u7684\u8f93\u6ce8\u901f\u7387\u4ee5\u964d\u4f4e\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\u7684\u53d1\u751f\u98ce\u9669\u3002\u5bf9\u4e8e\u4efb\u4f55\u7b49\u7ea7<span>\/<\/span>\u4e25\u91cd\u7a0b\u5ea6\u7684<span>IRR<\/span>\uff0c\u5e94\u7acb\u5373\u4e2d\u65ad\u672c\u54c1\u8f93\u6ce8\u5e76\u5bf9\u75c7\u6cbb\u7597\u3002\u8fbe\u96f7\u59a5\u5c24\u5355\u6297<span>IRR<\/span>\u4e3b\u8981\u53d1\u751f\u5728\u9996\u6b21\u8f93\u6ce8\u540e\u7ea6\u4e3a<span>46%<\/span>\uff0c\u53d1\u751f<span>IRR<\/span>\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a<span>1.5<\/span>\u5c0f\u65f6\uff0c\u7531\u4e8e\u53cd\u5e94\u5f15\u8d77\u7684\u8f93\u6ce8\u4e2d\u65ad\u53d1\u751f\u7387\u4e3a<span>35%<\/span>\u3002\u8f93\u6db2\u4e2d\u65ad\u540e\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u53ef\u5728\u5ba4\u6e29\u4e0b\u4fdd\u5b58<span>15<\/span>\u5c0f\u65f6\uff08\u5305\u62ec\u8f93\u6ce8\u65f6\u95f4\uff09\u3002\u53d1\u751f<span>1<\/span>\uff5e<span>2<\/span>\u7ea7\uff08\u8f7b\u4e2d\u5ea6\uff09\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\u7684\u75c7\u72b6\u6d88\u9000\u540e\uff0c\u53ef\u4ee5\u8003\u8651\u91cd\u65b0\u5f00\u59cb\u8f93\u6ce8\uff0c\u4f46\u662f\u901f\u7387\u4e0d\u5f97\u5927\u4e8e\u53d1\u751f<span>IRR<\/span>\u65f6\u8f93\u6ce8\u901f\u7387\u7684\u4e00\u534a\u3002\u5982\u679c\u60a3\u8005\u672a\u53d1\u751f\u4efb\u4f55\u8fdb\u4e00\u6b65\u7684<span>IRR<\/span>\u75c7\u72b6\uff0c\u53ef\u4ee5\u7ee7\u7eed\u9012\u589e\u8f93\u6ce8\u901f\u7387\uff0c\u589e\u91cf\u548c\u95f4\u9694\u89c6\u4e34\u5e8a\u60c5\u51b5\u800c\u5b9a\uff0c\u76f4\u81f3\u6700\u5927\u901f\u7387<span>200ml\/<\/span>\u5c0f\u65f6\u3002\u53d1\u751f<span>3<\/span>\u7ea7\uff08\u91cd\u5ea6\uff09\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\u7684\u75c7\u72b6\u6d88\u9000\u540e\uff0c\u53ef\u4ee5\u8003\u8651\u91cd\u65b0\u5f00\u59cb\u8f93\u6ce8\uff0c\u4f46\u662f\u901f\u7387\u4e0d\u5f97\u5927\u4e8e\u53d1\u751f<span>IRR<\/span>\u65f6\u8f93\u6ce8\u901f\u7387\u7684\u4e00\u534a\u3002\u5982\u679c\u60a3\u8005\u6ca1\u6709\u51fa\u73b0\u5176\u4ed6\u75c7\u72b6\uff0c\u53ef\u4ee5\u91cd\u65b0\u5f00\u59cb\u9012\u589e\u8f93\u6ce8\u901f\u7387\uff0c\u589e\u91cf\u548c\u95f4\u9694\u89c6\u4e34\u5e8a\u60c5\u51b5\u800c\u5b9a\u3002\u5982\u679c\u518d\u6b21\u53d1\u751f<span>3<\/span>\u7ea7\u75c7\u72b6\uff0c\u5e94\u91cd\u590d\u4e0a\u8ff0\u6b65\u9aa4\u3002\u7b2c\u4e09\u6b21\u53d1\u751f<span>\u22653<\/span>\u7ea7\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\u65f6\uff0c\u5e94\u6c38\u4e45\u7ec8\u6b62\u672c\u54c1\u6cbb\u7597\u3002\u53d1\u751f<span>4<\/span>\u7ea7\uff08\u5371\u53ca\u751f\u547d\uff09<span>IRR<\/span>\uff0c\u5e94\u6c38\u4e45\u7ec8\u6b62\u672c\u54c1\u6cbb\u7597\u3002\u6bcf\u6b21\u8f93\u6ce8\u672c\u54c1\u524d<span>1<\/span>\uff5e<span>3<\/span>\u5c0f\u65f6\u7ed9\u4e88\u6240\u6709\u60a3\u8005\u4ee5\u4e0b\u8f93\u6ce8\u524d\u7528\u836f\uff0c\u53ef\u4ee5\u964d\u4f4e<span>IRR<\/span>\u98ce\u9669\uff1a\uff08<span>1<\/span>\uff09\u7cd6\u76ae\u8d28\u6fc0\u7d20\uff08\u957f\u6548\u6216\u4e2d\u6548\uff09\uff1a\u9759\u8109\u8f93\u6ce8<span>100mg<\/span>\u7532\u6cfc\u5c3c\u9f99\u6216\u7b49\u6548\u836f\u7269\u3002\u5728\u7b2c\u4e8c\u6b21\u8f93\u6ce8\u540e\uff0c\u53ef\u4ee5\u51cf\u5c11\u7cd6\u76ae\u8d28\u6fc0\u7d20\u5242\u91cf\uff08\u53e3\u670d\u6216\u9759\u8109\u5185\u7ed9\u4e88\u7532\u6cfc\u5c3c\u9f99<span>60mg<\/span>\uff09\u3002\uff08<span>2<\/span>\uff09\u9000\u70ed\u5242\uff08\u53e3\u670d\u5bf9\u4e59\u9170\u6c28\u57fa\u915a<span>650<\/span>\uff5e<span>1000mg<\/span>\uff09\u3002\uff08<span>3<\/span>\uff09\u6297\u7ec4\u80fa\u836f\uff08\u53e3\u670d\u6216\u9759\u8109\u5185\u7ed9\u4e88\u82ef\u6d77\u62c9\u660e<span>25<\/span>\uff5e<span>50mg<\/span>\u6216\u7b49\u6548\u836f\u7269\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fdf\u53d1\u6027\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\uff1a\u8868\u73b0\u4e3a\u5ef6\u8fdf\u53d1\u70ed\u3002\u53ef\u5728\u6bcf\u6b21\u8f93\u6ce8\u672c\u54c1\u540e<span>2<\/span>\u5929\uff08\u4ece\u8f93\u6ce8\u540e\u6b21\u65e5\u5f00\u59cb\uff09\u6bcf\u5929\u7ed9\u4e88\u53e3\u670d\u7cd6\u76ae\u8d28\u6fc0\u7d20\uff08<span>20mg<\/span>\u7532\u6cfc\u5c3c\u9f99\u6216\u7b49\u6548\u5242\u91cf\u7684\u4e2d\u6548<span>\/<\/span>\u957f\u6548\u7cd6\u76ae\u8d28\u6fc0\u7d20\uff0c\u89c6\u5f53\u5730\u6807\u51c6\u800c\u5b9a\uff09\u964d\u4f4e\u8fdf\u53d1\u6027\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\u7684\u98ce\u9669\u3002\u53e6\u5916\uff0c\u5bf9\u4e8e\u60a3\u6709\u6162\u6027\u963b\u585e\u6027\u80ba\u75be\u75c5\u75c5\u53f2\u7684\u60a3\u8005\uff0c\u5e94\u8003\u8651\u4f7f\u7528\u5305\u62ec\u77ed\u6548\u548c\u957f\u6548\u652f\u6c14\u7ba1\u6269\u5f20\u5242\u4ee5\u53ca\u5438\u5165\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u5728\u5185\u7684\u8f93\u6ce8\u540e\u7528\u836f\u3002\u5728\u524d\u56db\u6b21\u8f93\u6ce8\u4e4b\u540e\uff0c\u5982\u679c\u60a3\u8005\u6ca1\u6709\u53d1\u751f\u91cd\u5927<span>IRR<\/span>\uff0c\u5219\u53ef\u4ee5\u7531\u533b\u5e08\u81ea\u884c\u51b3\u5b9a\u505c\u7528\u8fd9\u4e9b\u5438\u5165\u6027\u8f93\u6ce8\u540e\u836f\u7269\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u8840\u578b\u5224\u5b9a\u7684\u5f71\u54cd\u4ee5\u53ca\u8f93\u8840\u7b56\u7565\uff1a\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u53ef\u4ee5\u4e0e\u7ea2\u7ec6\u80de\u819c\u8868\u9762\u4f4e\u6c34\u5e73\u8868\u8fbe\u7684<span>CD38<\/span>\u6297\u539f\u7ed3\u5408\uff0c\u9020\u6210\u4ea4\u53c9\u914d\u8840\u8fc7\u7a0b\u4e2d\u7684\u95f4\u63a5\u6297\u4eba\u7403\u86cb\u767d\u8bd5\u9a8c\u5047\u9633\u6027\uff0c\u5e72\u6270\u914d\u8840\uff0c\u8fd9\u79cd\u5047\u9633\u6027\u53ef\u80fd\u6301\u7eed\u5230\u672b\u6b21\u8f93\u6ce8\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u540e<span>6<\/span>\u4e2a\u6708\u3002\u5e94\u5728\u60a3\u8005\u5f00\u59cb\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u6cbb\u7597\u524d\u5b8c\u6210\u8840\u578b\u5224\u5b9a\u5e76\u8fdb\u884c\u6297\u4f53\u7b5b\u67e5\u3002\u5728\u8ba1\u5212\u8f93\u8840\u7684\u60c5\u51b5\u4e0b\uff0c\u5e94\u901a\u77e5\u8f93\u8840\u4e2d\u5fc3\u8fd9\u4e00\u95f4\u63a5\u6297\u7403\u86cb\u767d\u8bd5\u9a8c\u7684\u5e72\u6270\u56e0\u7d20\u3002\u5e94\u7528\u4e8c\u786b\u82cf\u7cd6\u9187\u5904\u7406\u5f85\u68c0\u60a3\u8005\u7ea2\u7ec6\u80de\u662f\u5904\u7406\u65b9\u6cd5\u4e4b\u4e00\u3002\u7ea2\u7ec6\u80de\u57fa\u56e0\u5206\u578b\u4e0d\u53d7\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u7684\u5f71\u54cd\uff0c\u53ef\u4ee5\u968f\u65f6\u8fdb\u884c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u6709\u9aa8\u9ad3\u6291\u5236\uff0c\u5e94\u7528\u540e\u9700\u8981\u6ce8\u610f\u8840\u5e38\u89c4\u7684\u76d1\u6d4b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u53ef\u80fd\u4f1a\u5f15\u8d77\u5e26\u72b6\u75b1\u75b9\u611f\u67d3\u98ce\u9669\u589e\u52a0\uff0c\u7ea6<span>3%<\/span>\u7684\u60a3\u8005\u62a5\u544a\u4e86\u5e26\u72b6\u75b1\u75b9\u518d\u6fc0\u6d3b\u3002\u65e0\u8bba\u5355\u836f\u4f7f\u7528\u8fd8\u662f\u4e0e\u5176\u4ed6\u4efb\u610f\u65b9\u6848\u8054\u7528\uff0c\u90fd\u63a8\u8350\u4f7f\u7528\u6297\u75c5\u6bd2\u9884\u9632\u6027\u6cbb\u7597\u6765\u9884\u9632\u5e26\u72b6\u75b1\u75b9\u75c5\u6bd2\u518d\u6fc0\u6d3b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u4f34\u6709\u809d\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u4e0d\u9700\u8981\u8c03\u6574\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u6709\u4e59\u809d\u75c5\u6bd2\u518d\u71c3\u7684\u98ce\u9669\u3002\u5728\u4f7f\u7528\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u6cbb\u7597\u524d\u5e94\u8fdb\u884c\u4e59\u809d\u75c5\u6bd2\u7b5b\u67e5\uff0c\u4e59\u809d\u75c5\u6bd2\u643a\u5e26\u8005\u5e94\u9884\u9632\u6027\u4f7f\u7528\u6291\u5236\u75c5\u6bd2\u590d\u5236\u7684\u836f\u7269\u53ca\u76d1\u6d4b\u75c5\u6bd2\u8f7d\u91cf\uff1b\u5728\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u6cbb\u7597\u4e2d\uff0c\u82e5\u51fa\u73b0\u4e59\u809d\u75c5\u6bd2\u518d\u6fc0\u6d3b\u7684\u60a3\u8005\uff0c\u5e94\u505c\u6b62\u4f7f\u7528\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u53ca\u4efb\u4f55\u8054\u5408\u6fc0\u7d20\u3001\u5316\u7597\uff0c\u5e76\u7ed9\u4e88\u9002\u5f53\u7684\u6cbb\u7597\u3002\u5bf9\u4e8e\u4e59\u809d\u75c5\u6bd2\u8840\u6e05\u5b66\u68c0\u6d4b\u7ed3\u679c\u5448\u9633\u6027\u7684\u60a3\u8005\uff0c\u5e94\u5728\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u4ee5\u53ca\u6cbb\u7597\u7ed3\u675f\u540e\u81f3\u5c11<span>6<\/span>\u4e2a\u6708\u5185\u76d1\u6d4b\u4e59\u809d\u75c5\u6bd2\u518d\u6fc0\u6d3b\u7684\u4e34\u5e8a\u548c\u5b9e\u9a8c\u5ba4\u6307\u5f81\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5176\u4ed6\u6cbb\u7597\uff1a\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u8054\u5408\u5730\u585e\u7c73\u677e\u53ca\u787c\u66ff\u4f50\u7c73\u7528\u4e8e\u521d\u8bca\u7684\u7cfb\u7edf\u6027\u8f7b\u94fe\u578b\u6dc0\u7c89\u6837\u53d8\u4e2d\u7684<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5728\u8fdb\u884c\u4e2d\uff0c\u4e2d\u671f\u5206\u6790\u542b\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u7ec4\u8f83\u5bf9\u7167\u7ec4\u8840\u6db2\u5b66\u7f13\u89e3\u7387\u660e\u663e\u589e\u52a0\u3002\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u8054\u5408\u5176\u4ed6\u836f\u7269\u5728<span>NCCN<\/span>\u6307\u5357\u5df2\u7ecf\u83b7\u6279\u7528\u4e8e\u96be\u6cbb\u590d\u53d1\u4ee5\u53ca\u521d\u6cbb\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u6cbb\u7597\uff0c\u5305\u62ec\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u8054\u5408\u6765\u90a3\u5ea6\u80fa\u53ca\u5730\u585e\u7c73\u677e\u7528\u4e8e\u590d\u53d1\u60a3\u8005\u4ee5\u53ca\u8001\u5e74\u521d\u6cbb\u60a3\u8005\uff0c\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u8054\u5408\u787c\u66ff\u4f50\u7c73\u53ca\u5730\u585e\u7c73\u677e\u7528\u4e8e\u96be\u6cbb\u590d\u53d1\u60a3\u8005\uff0c\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u8054\u5408\u787c\u66ff\u4f50\u7c73\u3001\u7f8e\u6cd5\u4ed1\u53ca\u918b\u9178\u6cfc\u5c3c\u677e\u7528\u4e8e\u8001\u5e74\u521d\u6cbb\u60a3\u8005\uff0c\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u8054\u5408\u787c\u66ff\u4f50\u7c73\u3001\u6c99\u5229\u5ea6\u80fa\u53ca\u5730\u585e\u7c73\u677e\u7528\u4e8e\u5e74\u8f7b\u521d\u6cbb\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e00\u3001\u82a6\u53ef\u66ff\u5c3c<span> Ruxolitinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>5mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u4e2d\u5371\u6216\u9ad8\u5371\u7684\u539f\u53d1\u6027\u9aa8\u9ad3\u7ea4\u7ef4\u5316\uff08\u4ea6\u79f0\u4e3a\u6162\u6027\u7279\u53d1\u6027\u9aa8\u9ad3\u7ea4\u7ef4\u5316\uff09\u3001\u771f\u6027\u7ea2\u7ec6\u80de\u589e\u591a\u75c7\u7ee7\u53d1\u7684\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u6216\u539f\u53d1\u6027\u8840\u5c0f\u677f\u589e\u591a\u75c7\u7ee7\u53d1\u7684\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u7684\u6210\u5e74\u60a3\u8005\uff0c\u6cbb\u7597\u75be\u75c5\u76f8\u5173\u813e\u80bf\u5927\u6216\u75be\u75c5\u76f8\u5173\u75c7\u72b6\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u5242\u91cf\uff1a\u6309\u7167\u8840\u5c0f\u677f\u8ba1\u6570\u7ed9\u4e88\u8d77\u59cb\u5242\u91cf\u3002\uff08<span>1<\/span>\uff09\u8840\u5c0f\u677f\u8ba1\u6570\u5728\uff08<span>100<\/span>\uff5e<span>200<\/span>\uff09<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u00d7<span>10<sup>9<\/sup>\/L<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u8d77\u59cb\u5242\u91cf\u4e3a<span>15mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u3002\uff08<span>2<\/span>\uff09\u8840\u5c0f\u677f\u8ba1\u6570\uff1e<span>200<\/span><\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u00d7<span>10<sup>9<\/sup>\/L<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u8d77\u59cb\u5242\u91cf\u4e3a<span>20mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u3002\uff08<span>3<\/span>\uff09\u8840\u5c0f\u677f\u8ba1\u6570\u5728\uff08<span>50<\/span>\uff5e<span>100<\/span>\uff09<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u00d7<span>10<sup>9<\/sup>\/L<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u8d77\u59cb\u5242\u91cf\u4e3a<span>5mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u53ef\u80fd\u9020\u6210\u8840\u6db2\u7cfb\u7edf\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u8840\u5c0f\u677f\u51cf\u5c11\u3001\u8d2b\u8840\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u3002\u6cbb\u7597\u524d\uff0c\u5fc5\u987b\u8fdb\u884c\u5168\u8840\u7ec6\u80de\u8ba1\u6570\u68c0\u67e5\uff0c\u4e4b\u540e\u6bcf\u5468\u76d1\u6d4b\u4e00\u6b21\uff0c<span>4<\/span>\u5468\u540e\u53ef\u6bcf<span>2<\/span>\uff5e<span>4<\/span>\u5468\u76d1\u6d4b\u4e00\u6b21\uff0c\u76f4\u5230\u8fbe\u5230\u7a33\u5b9a\uff0c\u7136\u540e\u53ef\u4ee5\u6839\u636e\u4e34\u5e8a\u9700\u8981\u8fdb\u884c\u76d1\u6d4b\u3002\u5f53\u51fa\u73b0\u8840\u5c0f\u677f\u51cf\u5c11\u6216\u8d2b\u8840\u65f6\uff0c\u53ef\u51cf\u5c11\u5242\u91cf\u6216\u6682\u65f6\u505c\u6b62\u7528\u836f\uff0c\u5fc5\u8981\u65f6\u8f93\u6ce8\u8840\u5c0f\u677f\u6216\u7ea2\u7ec6\u80de\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e2d\u65ad\u6216\u7ec8\u6b62\u672c\u54c1\u6cbb\u7597\u540e\uff0c\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u7684\u75c7\u72b6\u53ef\u80fd\u5728\u5927\u7ea6\u4e00\u5468\u540e\u518d\u6b21\u51fa\u73b0\u3002\u82e5\u975e\u5fc5\u987b\u7d27\u6025\u7ec8\u6b62\u6cbb\u7597\uff0c\u5e94\u53ef\u4ee5\u8003\u8651\u9010\u6b65\u51cf\u5c11\u672c\u54c1\u7684\u7528\u836f\u5242\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u4e0e\u5f3a\u6548<span>CYP3A4<\/span>\u6291\u5236\u5242\u6216<span>CYP2C9<\/span>\u548c<span>CYP3A4<\/span>\u9176\u53cc\u91cd\u6291\u5236\u5242\u5408\u5e76\u4f7f\u7528\u65f6\uff0c\u6bcf\u5929\u603b\u5242\u91cf\u5e94\u51cf\u5c11\u7ea6<span>50%<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p><b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><br \/>\n<\/span><\/b> <\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ccc\u5c3f\u7cfb\u7edf\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e00\u3001\u4f9d\u7ef4\u83ab\u53f8<span> Everolimus<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>2.5mg<\/span>\u3001<span>5mg<\/span>\u3001<span>10mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u63a5\u53d7\u8212\u5c3c\u66ff\u5c3c\u6216\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u5931\u8d25\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\uff08<span>RCC<\/span>\uff09\uff0c\u6570\u636e\u4e3b\u8981\u57fa\u4e8e\u900f\u660e\u7ec6\u80de\u80be\u764c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0e\u4ed1\u4f10\u66ff\u5c3c\u8054\u7528\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u6297\u8840\u7ba1\u751f\u6210\u836f\u7269\u6cbb\u7597\u5931\u8d25\u6216\u8fdb\u5c55\u7684\u665a\u671f<span>RCC<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u809d\u529f\u80fd\u635f\u4f24\u4f1a\u4f7f\u4f9d\u7ef4\u83ab\u53f8\u66b4\u9732\u91cf\u589e\u52a0\uff0c\u6309\u5982\u4e0b\u65b9\u5f0f\u8fdb\u884c\u7ed9\u836f\u8c03\u6574\uff1a\uff08<span>1<\/span>\uff09\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\uff08<span>Child-Pugh A<\/span>\u7ea7\uff09\uff1a\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u5929<span>7.5mg<\/span>\uff1b\u5982\u679c\u4e0d\u80fd\u5f88\u597d\u5730\u8010\u53d7\uff0c\u53ef\u5c06\u5242\u91cf\u964d\u81f3\u6bcf\u5929<span>5mg<\/span>\u3002\uff08<span>2<\/span>\uff09\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\uff08<span>Child-Pugh B<\/span>\u7ea7\uff09\uff1a\u63a8\u8350\u5242\u91cf\u662f\u6bcf\u5929<span>5mg<\/span>\uff1b\u5982\u679c\u4e0d\u80fd\u5f88\u597d\u5730\u8010\u53d7\uff0c\u53ef\u5c06\u5242\u91cf\u964d\u81f3\u6bcf\u5929<span>2.5mg<\/span>\u3002\uff08<span>3<\/span>\uff09\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\uff08<span>Child-Pugh C<\/span>\u7ea7\uff09\uff1a\u5982\u679c\u9884\u671f\u7684\u83b7\u76ca\u9ad8\u4e8e\u98ce\u9669\uff0c\u53ef\u4ee5\u91c7\u7528\u6bcf\u5929<span>2.5mg<\/span>\uff0c\u4f46\u4e0d\u5f97\u8d85\u8fc7\u8fd9\u4e00\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u53e3\u8154\u708e\u7b49\uff1b\u5e94\u7279\u522b\u6ce8\u610f\u975e\u611f\u67d3\u6027\u80ba\u708e\u7684\u53d1\u751f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u5408\u5e76\u4f7f\u7528\u5f3a\u6548<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u5e94\u907f\u514d\u63a5\u79cd\u6d3b\u75ab\u82d7\uff0c\u907f\u514d\u4e0e\u63a5\u79cd\u8fc7\u6d3b\u75ab\u82d7\u7684\u4eba\u5bc6\u5207\u63a5\u89e6\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u548c\u4ed1\u4f10\u66ff\u5c3c\u7684\u8054\u5408\u6cbb\u7597\u7684\u5176\u4ed6\u6ce8\u610f\u4e8b\u9879\u8bf7\u53c2\u8003\u201c\u4ed1\u4f10\u66ff\u5c3c\u201d\u90e8\u5206\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u7d22\u62c9\u975e\u5c3c<span> Sorafenib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>200mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u665a\u671f\u80be\u764c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.CYP3A4<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8bf1\u5bfc\u5242\u8054\u5408\u7d22\u62c9\u975e\u5c3c\u53ef\u51cf\u4f4e\u7d22\u62c9\u975e\u5c3c\u7684\u836f\u7269\u6d53\u5ea6\uff0c\u800c\u6839\u636e\u76ee\u524d\u6570\u636e\uff0c<span>CYP3A4<\/span>\u6291\u5236\u5242\u548c\u7d22\u62c9\u975e\u5c3c\u5728\u4e34\u5e8a\u836f\u4ee3\u52a8\u529b\u5b66\u65b9\u9762\u4e0d\u592a\u53ef\u80fd\u5b58\u5728\u76f8\u4e92\u4f5c\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7a7a\u8179\u7ed9\u836f\uff0c\u7528\u836f\u524d\u65e0\u9700\u8fdb\u884c\u57fa\u56e0\u68c0\u6d4b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b58\u5728\u53ef\u7591\u7684\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u65f6\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u548c<span>\/<\/span>\u6216\u51cf\u5c11\u7d22\u62c9\u975e\u5c3c\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u6709\u8179\u6cfb\u3001\u4e4f\u529b\u3001\u8131\u53d1\u3001\u611f\u67d3\u3001\u624b\u8db3\u76ae\u80a4\u53cd\u5e94\u3001\u76ae\u75b9\u3002\u907f\u514d\u5e94\u7528<span>CYP3A4<\/span>\u5f3a\u6548\u6291\u5236\u5242\u548c\u5f3a\u6548\u8bf1\u5bfc\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u7d22\u62c9\u975e\u5c3c\u6216\u672c\u54c1\u4efb\u4e00\u975e\u6d3b\u6027\u6210\u5206\u6709\u4e25\u91cd\u8fc7\u654f\u75c7\u72b6\u7684\u60a3\u8005\u7981\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e09\u3001\u8212\u5c3c\u66ff\u5c3c<span> Sunitinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>12.5mg<\/span>\u3001<span>25mg<\/span>\u3001<span>37.5mg<\/span>\u3001<span>50mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u665a\u671f\u80be\u764c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a<span>50mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u53e3\u670d\uff0c\u670d\u836f<span>4<\/span>\u5468\uff0c\u505c\u836f<span>2<\/span>\u5468\uff08<span>4\/2<\/span>\u7ed9\u836f\u65b9\u6848\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u60a3\u8005\u4e2a\u4f53\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u4ee5<span>12.5mg<\/span>\u4e3a\u68af\u5ea6\u5355\u4f4d\u9010\u6b65\u8c03\u6574\u5242\u91cf\u3002\u6bcf\u5929\u6700\u9ad8\u5242\u91cf\u4e0d\u8d85\u8fc7<span>75mg<\/span>\uff0c\u6700\u4f4e\u5242\u91cf\u4e3a<span>25mg<\/span>\u3002\u6839\u636e\u60a3\u8005\u4e2a\u4f53\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u60c5\u51b5\u53ef\u80fd\u9700\u8981\u4e2d\u65ad\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u4e0e\u5f3a\u6548<span>CYP3A4\/5<\/span>\u6291\u5236\u5242\u6216\u8bf1\u5bfc\u5242\u5408\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8212\u5c3c\u66ff\u5c3c\u670d\u7528<span>4<\/span>\u5468\uff0c\u505c\u836f<span>2<\/span>\u5468\uff08<span>4\/2<\/span>\u7ed9\u836f\u65b9\u6848\uff09\u53ef\u80fd\u4f1a\u53d1\u73b0\u767d\u7ec6\u80de\u53ca\u8840\u5c0f\u677f\u4e0b\u964d\u7b49\u4e25\u91cd\u9aa8\u9ad3\u6291\u5236\uff0c\u56e0\u6b64\u7528\u836f\u671f\u95f4\u9700\u8981\u5bc6\u5207\u76d1\u6d4b\u8840\u5e38\u89c4\u3002\u5fc5\u8981\u65f6\u53ef\u91c7\u7528<span>2\/1<\/span>\u7ed9\u836f\u65b9\u6848\uff0c\u5373\u8212\u5c3c\u66ff\u5c3c\u670d\u7528<span>2<\/span>\u5468\uff0c\u505c\u836f<span>1<\/span>\u5468\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56db\u3001\u963f\u6614\u66ff\u5c3c<span> Axitinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>1mg<\/span>\u3001<span>5mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e00\u79cd\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u6216\u7ec6\u80de\u56e0\u5b50\u6cbb\u7597\u5931\u8d25\u7684\u8fdb\u5c55\u671f<span>RCC<\/span>\u7684\u6210\u4eba\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u9002\u7528\u4e8e\u665a\u671f\u80be\u900f\u660e\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u6614\u66ff\u5c3c\u63a8\u8350\u7684\u8d77\u59cb\u53e3\u670d\u5242\u91cf\u4e3a<span>5mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u53ef\u4e0e\u98df\u7269\u540c\u670d\u6216\u7a7a\u8179\u7ed9\u836f\uff0c\u6bcf\u5929\u4e24\u6b21\u7ed9\u836f\u7684\u65f6\u95f4\u95f4\u9694\u7ea6\u4e3a<span>12<\/span>\u5c0f\u65f6\u3002\u53ea\u8981\u89c2\u5bdf\u5230\u4e34\u5e8a\u83b7\u76ca\uff0c\u5c31\u5e94\u7ee7\u7eed\u6cbb\u7597\u76f4\u81f3\u53d1\u751f\u4e0d\u80fd\u63a5\u53d7\u7684\u6bd2\u6027\u3002\u5982\u679c\u60a3\u8005\u5455\u5410\u6216\u6f0f\u670d\u4e00\u6b21\u5242\u91cf\uff0c\u4e0d\u5e94\u53e6\u5916\u670d\u7528\u4e00\u6b21\u5242\u91cf\uff0c\u5e94\u6309\u5e38\u89c4\u670d\u7528\u4e0b\u4e00\u6b21\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u6839\u636e\u60a3\u8005\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u7684\u4e2a\u4f53\u5dee\u5f02\u589e\u52a0\u6216\u964d\u4f4e\u5242\u91cf\uff1a\uff08<span>1<\/span>\uff09\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\uff0c\u6ee1\u8db3\u4e0b\u8ff0\u6807\u51c6\u7684\u60a3\u8005\u53ef\u589e\u52a0\u5242\u91cf\uff1a\u80fd\u8010\u53d7\u963f\u6614\u66ff\u5c3c\u81f3\u5c11\u4e24\u5468\u8fde\u7eed\u6cbb\u7597\u3001\u672a\u51fa\u73b0<span>2<\/span>\u7ea7\u4ee5\u4e0a\u4e0d\u826f\u53cd\u5e94\u3001\u8840\u538b\u6b63\u5e38\u3001\u672a\u63a5\u53d7\u964d\u538b\u836f\u7269\u6cbb\u7597\u3002\u5f53\u63a8\u8350\u4ece<span>5mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u5f00\u59cb\u589e\u52a0\u5242\u91cf\u65f6\uff0c\u53ef\u5c06\u963f\u6614\u66ff\u5c3c\u5242\u91cf\u589e\u52a0\u81f3<span>7mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u7136\u540e\u91c7\u7528\u76f8\u540c\u6807\u51c6\uff0c\u8fdb\u4e00\u6b65\u5c06\u5242\u91cf\u589e\u52a0\u81f3<span>10mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u3002\uff08<span>2<\/span>\uff09\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u6216\u6c38\u4e45\u7ec8\u6b62\u7ed9\u836f\uff0c\u6216\u964d\u4f4e\u963f\u6614\u66ff\u5c3c\u5242\u91cf\u3002\u5982\u679c\u9700\u8981\u4ece<span>5mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u5f00\u59cb\u51cf\u91cf\uff0c\u5219\u63a8\u8350\u5242\u91cf\u4e3a<span>3mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u3002\u5982\u679c\u9700\u8981\u518d\u6b21\u51cf\u91cf\uff0c\u5219\u63a8\u8350\u5242\u91cf\u4e3a<span>2mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u4e0e\u5f3a\u6548<span>CYP3A4\/5<\/span>\u6291\u5236\u5242\u6216\u8bf1\u5bfc\u5242\u5408\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u665a\u671f\u80be\u900f\u660e\u7ec6\u80de\u764c\u65f6\uff0c\u63a8\u8350\u963f\u6614\u66ff\u5c3c\u7684\u5242\u91cf\u4e3a<span>5mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u5982\u80fd\u8010\u53d7\uff0c\u53ef\u8003\u8651\u5242\u91cf\u6ef4\u5b9a\u3002\u8054\u5408\u6cbb\u7597\u671f\u95f4\u5e15\u535a\u5229\u73e0\u5355\u6297\u7684\u7528\u836f\u8981\u70b9\u8bf7\u53c2\u89c1\u201c\u5e15\u535a\u5229\u73e0\u5355\u6297\u201d\u90e8\u5206\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e94\u3001\u57f9\u5511\u5e15\u5c3c<span> Pazopanib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>200mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u9002\u7528\u4e8e\u665a\u671f<span>RCC<\/span>\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u548c\u66fe\u63a5\u53d7\u7ec6\u80de\u56e0\u5b50\u6cbb\u7597\u7684\u665a\u671f<span>RCC<\/span>\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57f9\u5511\u5e15\u5c3c\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>800mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u7a7a\u8179\u670d\u836f\u3002\u5982\u679c\u6f0f\u670d\u5242\u91cf\uff0c\u4e14\u8ddd\u4e0b\u6b21\u5242\u91cf\u7684\u670d\u7528\u65f6\u95f4\u4e0d\u8db3<span>12<\/span>\u5c0f\u65f6\uff0c\u5219\u4e0d\u5e94\u8865\u670d\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u8c03\u6574\u5e94\u6839\u636e\u4e2a\u4f53\u8010\u53d7\u60c5\u51b5\uff0c\u6309<span>200mg<\/span>\u7684\u5e45\u5ea6\u9010\u6b65\u9012\u589e\u6216\u9012\u51cf\uff0c\u4ee5\u63a7\u5236\u4e0d\u826f\u53cd\u5e94\u3002\u57f9\u5511\u5e15\u5c3c\u7684\u5242\u91cf\u4e0d\u5e94\u8d85\u8fc7<span>800mg<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u57f9\u5511\u5e15\u5c3c\u4f7f\u7528\u671f\u95f4\uff0c\u8f7b\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u614e\u7528\u57f9\u5511\u5e15\u5c3c\uff0c\u5e76\u4e14\u5e94\u5bc6\u5207\u76d1\u6d4b\uff0c\u5bf9\u4e8e\u57fa\u7ebf\u603b\u80c6\u7ea2\u7d20\u7684\u6570\u503c\u2264<span>1.5<\/span>\u500d<span>ULN<\/span>\uff0c\u4e14<span>AST<\/span>\u53ca<span>ALT<\/span>\u7684\u6570\u503c\u2264<span>2<\/span>\u500d<span>ULN<\/span>\u7684\u60a3\u8005\uff0c\u5176\u5242\u91cf\u8c03\u6574\u53c2\u89c1\u9488\u5bf9\u836f\u7269\u6027\u809d\u6bd2\u6027\u7684\u5242\u91cf\u8c03\u6574\u6307\u5357\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u809d\u529f\u80fd\u635f\u4f24\u548c\u9ad8\u8840\u538b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u540c\u65f6\u4f7f\u7528<span>CYP3A4<\/span>\u3001<span>P-<\/span>\u7cd6\u86cb\u767d\u6216\u4e73\u817a\u764c\u8010\u836f\u86cb\u767d\u7684\u5f3a\u6291\u5236\u5242\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u516d\u3001\u4ed1\u4f10\u66ff\u5c3c<span> Lenvatinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>4mg<\/span>\u3001<span>10mg<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0e\u4f9d\u7ef4\u83ab\u53f8\u8054\u7528\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u6297\u8840\u7ba1\u751f\u6210\u836f\u7269\u6cbb\u7597\u5931\u8d25\u6216\u8fdb\u5c55\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\uff08<span>RCC<\/span>\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a<span>18mg<\/span>\u53e3\u670d\u8054\u5408\u4f9d\u7ef4\u83ab\u53f8<span>5mg<\/span>\u53e3\u670d\uff0c\u6bcf\u5929\u4e00\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u5408\u5e76\u4f7f\u7528\u5f3a\u6548<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u8fc7\u7a0b\u9700\u5bc6\u5207\u76d1\u6d4b\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f\u3002\u5728\u80be\u764c\u6cbb\u7597\u4e2d\uff0c\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u2265<span>30%<\/span>\uff09\u4e3a\u8179\u6cfb\u3001\u4e4f\u529b\u3001\u9aa8\u5173\u8282\u75bc\u75db\u3001\u98df\u6b32\u51cf\u9000\u3001\u6076\u5fc3\u3001\u5455\u5410\u3001\u53e3\u8154\u708e\u3001\u9ad8\u8840\u538b\u7b49\u3002\u5fc5\u8981\u65f6\u51cf\u91cf\u3001\u6682\u505c\u7528\u836f\u6216\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51cf\u91cf\u63a8\u8350\uff1a\u9700\u6309\u7167<span>18mg<\/span>\u2192<span>14mg<\/span>\u2192<span>10mg<\/span>\u2192<span>8mg<\/span>\u7684\u5242\u91cf\u51cf\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e25\u91cd\u80be\u529f\u80fd\u635f\u4f24\u548c\u809d\u529f\u80fd\u635f\u4f24\u7684\u60a3\u8005\uff0c\u4ed1\u4f10\u66ff\u5c3c\u7684\u5242\u91cf\u5e94\u6539\u4e3a<span>10mg<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4ed1\u4f10\u66ff\u5c3c\u5e94\u5728\u6bcf\u5929\u56fa\u5b9a\u65f6\u95f4\u670d\u7528\uff0c\u7a7a\u8179\u6216\u4e0e\u98df\u7269\u540c\u670d\u5747\u53ef\u3002\u5982\u679c\u60a3\u8005\u9057\u6f0f\u4e00\u6b21\u7528\u836f\u4e14\u65e0\u6cd5\u5728<span>12<\/span>\u5c0f\u65f6\u5185\u670d\u7528\uff0c\u65e0\u9700\u8865\u670d\uff0c\u5e94\u6309\u5e38\u89c4\u7528\u836f\u65f6\u95f4\u8fdb\u884c\u4e0b\u4e00\u6b21\u670d\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e03\u3001\u7eb3\u6b66\u5229\u5c24\u5355\u6297<span> Nivolumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>40mg<\/span>\uff08<span>4ml<\/span>\uff09<span>\/<\/span>\u74f6\u3001<span>100mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\u9002\u7528\u4e8e\u56fd\u9645\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\u8054\u5408\u6570\u636e\u5e93\uff08<span>IMDC<\/span>\uff09\u8bc4\u5206\u4e3a\u4e2d\u9ad8\u5371\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\u7528\u4e8e<span>IMDC<\/span>\u8bc4\u5206\u4e3a\u4e2d\u9ad8\u5371\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u57fa\u4e8e<span>CheckMate214<\/span>\u7814\u7a76\u3002\u8be5\u6cbb\u7597\u65b9\u6cd5\u5df2\u83b7\u5f97\u7f8e\u56fd<span>FDA<\/span>\u548c\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\u83b7\u6279\uff0c\u63a8\u8350\u4e34\u5e8a\u5242\u91cf\u662f\u7eb3\u6b66\u5229\u5c24\u5355\u6297<span>3mg\/kg<\/span>\u6bcf\u6b21\u6301\u7eed\u81f3\u5c11<span>60<\/span>\u5206\u949f<span>+<\/span>\u4f0a\u5339\u6728\u5355\u6297<span>1mg\/kg<\/span>\u6bcf\u6b21\u6301\u7eed\u81f3\u5c11<span>30<\/span>\u5206\u949f\uff0c\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c\u8fde\u7eed<span>4<\/span>\u6b21\u540e\uff0c\u6539\u4e3a\u7eb3\u6b66\u5229\u5c24\u5355\u6297<span>3mg\/kg<\/span>\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff0c\u6bcf\u6b21\u6301\u7eed\u81f3\u5c11<span>60<\/span>\u5206\u949f\u3002\u4f46\u8be5\u9002\u5e94\u8bc1\u5c1a\u672a\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\uff0c\u53ef\u5728\u4e0e\u60a3\u8005\u5145\u5206\u6c9f\u901a\u7684\u60c5\u51b5\u4e0b\u8003\u8651\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.IMDC<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8bc4\u5206\u5185\u5bb9\u5305\u62ec\uff1a\u8d2b\u8840\uff08\u4f4e\u4e8e\u6b63\u5e38\u503c\u4e0b\u9650\uff09\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u5347\u9ad8\uff08\u9ad8\u4e8e\u6b63\u5e38\u503c\u4e0a\u9650\uff09\u3001\u8840\u5c0f\u677f\u5347\u9ad8\uff08\u9ad8\u4e8e\u6b63\u5e38\u503c\u4e0a\u9650\uff09\u3001<span>KPS<\/span>\u8bc4\u5206\uff1c<span>80<\/span>\u3001\u4e00\u7ebf\u6cbb\u7597\u8ddd\u8bca\u65ad\u65f6\u95f4\uff1c<span>1<\/span>\u5e74\u3001\u9ad8\u9499\u8840\u75c7\u3002\u6bcf\u9879\u4e3a<span>1<\/span>\u5206\u3002\u603b\u5206<span>0<\/span>\u5206\u4e3a\u4f4e\u5371\u4eba\u7fa4\uff0c<span>1<\/span>\uff5e<span>2<\/span>\u5206\u4e3a\u4e2d\u5371\u4eba\u7fa4\uff0c\u2265<span>3<\/span>\u5206\u4e3a\u9ad8\u5371\u4eba\u7fa4\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56e0\u90e8\u5206\u60a3\u8005\u4f7f\u7528\u514d\u75ab\u6cbb\u7597\u53ef\u80fd\u4f1a\u51fa\u73b0\u5047\u6027\u8fdb\u5c55\uff08\u6cbb\u7597\u6700\u521d\u6570\u6708\u5185\u80bf\u7624\u51fa\u73b0\u77ed\u6682\u6027\u589e\u5927\u6216\u51fa\u73b0\u65b0\u7684\u5c0f\u75c5\u7076\uff0c\u968f\u540e\u80bf\u7624\u7f29\u5c0f\u751a\u81f3\u6d88\u5931\uff09\uff0c\u6545\u53ea\u8981\u89c2\u5bdf\u5230\u4e34\u5e8a\u83b7\u76ca\uff0c\u5e94\u7ee7\u7eed\u4f7f\u7528\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\u6216\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u5355\u836f\u6cbb\u7597\u81f3\u660e\u786e\u75be\u75c5\u8fdb\u5c55\u6216\u53d1\u751f\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u4f46\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u6682\u505c\u7ed9\u836f\u6216\u505c\u836f\u3002\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u5224\u65ad\u5176\u4e0e\u836f\u7269\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u53ca\u4f0a\u5339\u6728\u5355\u6297\u7684\u76f8\u5173\u6027\u3002\u5982\u53d1\u751f<span>4<\/span>\u7ea7\u6216\u590d\u53d1\u6027<span>3<\/span>\u7ea7\uff0c\u867d\u7136\u8fdb\u884c\u6cbb\u7597\u8c03\u6574\u4f46\u4ecd\u6301\u7eed\u5b58\u5728<span>2<\/span>\u7ea7\u6216<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u5145\u5206\u5206\u6790\u5f15\u53d1\u8be5\u4e0d\u826f\u53cd\u5e94\u7684\u53ef\u80fd\u7684\u836f\u7269\uff0c\u53ef\u80fd\u9700\u8981\u6c38\u4e45\u6027\u505c\u7528\u53cc\u6297\u6216\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6216\u4f0a\u5339\u6728\u5355\u6297\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8001\u5e74\u60a3\u8005\u6570\u636e\u6709\u9650\uff0c\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u6570\u636e\u6709\u9650\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u6ca1\u6709\u5bf9\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u8fdb\u884c\u672c\u54c1\u7684\u76f8\u5173\u7814\u7a76\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u00b1\u4f0a\u5339\u6728\u5355\u6297\u53ef\u5f15\u8d77\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u3002\u56e0\u4e3a\u4e0d\u826f\u53cd\u5e94\u53ef\u80fd\u5728\u514d\u75ab\u6cbb\u7597\u671f\u95f4\u6216\u514d\u75ab\u6cbb\u7597\u505c\u6b62\u540e\u7684\u4efb\u4f55\u65f6\u95f4\u53d1\u751f\uff0c\u5e94\u6301\u7eed\u8fdb\u884c\u60a3\u8005\u76d1\u6d4b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u6682\u505c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u5e76\u7ed9\u4e88\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u975e\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6027\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u3002\u5fc5\u8981\u65f6\u4e0e\u76f8\u5173\u9886\u57df\u5b66\u79d1\u8fdb\u884c\u591a\u5b66\u79d1\u8bca\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u60a3\u8005\u63a5\u53d7\u514d\u75ab\u6291\u5236\u5242\u91cf\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u6cbb\u7597\u671f\u95f4\uff0c\u4e0d\u53ef\u91cd\u65b0\u4f7f\u7528\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u516b\u3001\u5e15\u535a\u5229\u73e0\u5355\u6297<span> Pembrolizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>4ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u963f\u6614\u66ff\u5c3c\u9002\u7528\u4e8e\u665a\u671f\u80be\u900f\u660e\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u7528\u4e8e\u542b\u94c2\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u665a\u671f\u5c3f\u8def\u4e0a\u76ae\u764c\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u963f\u6614\u66ff\u5c3c\u7528\u4e8e\u665a\u671f\u80be\u900f\u660e\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u9002\u5e94\u8bc1\u662f\u57fa\u4e8e\u5168\u7403\u2162\u671f<span>KEYNOTE-426<\/span>\u4e34\u5e8a\u7814\u7a76\u7684\u7ed3\u679c\u3002\u5e15\u535a\u5229\u73e0\u5355\u6297\u901a\u8fc7\u9759\u8109\u6ce8\u5c04\u7ed9\u836f<span>200mg<\/span>\u56fa\u5b9a\u5242\u91cf\uff0c\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c\u6bcf\u6b21\u6301\u7eed\u81f3\u5c11<span>30<\/span>\u5206\u949f\uff0c\u963f\u6614\u66ff\u5c3c<span>5mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u53e3\u670d\uff08\u90e8\u5206\u60a3\u8005\u8fdb\u884c\u4e86\u5242\u91cf\u6ef4\u5b9a\uff09\u3002\u5e15\u535a\u5229\u73e0\u5355\u6297\u7528\u4e8e\u4e0d\u8010\u53d7\u94c2\u7c7b\u5316\u7597\u7684\u665a\u671f\u5c3f\u8def\u4e0a\u76ae\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u9002\u5e94\u8bc1\u662f\u57fa\u4e8e\u2161\u671f\u5355\u81c2\u4e34\u5e8a\u7814\u7a76<span>KEYNOTE-052<\/span>\u7684\u7814\u7a76\u7ed3\u679c\uff0c\u8be5\u8054\u5408\u65b9\u6848\u5df2\u83b7\u5f97\u7f8e\u56fd<span>FDA<\/span>\u6279\u51c6\uff0c\u4f46\u76ee\u524d\u5c1a\u672a\u5f97\u5230\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u7684\u6279\u51c6\uff0c\u53ef\u5728\u4e0e\u60a3\u8005\u5145\u5206\u6c9f\u901a\u7684\u60c5\u51b5\u4e0b\u8003\u8651\u4f7f\u7528\u3002\u5e15\u535a\u5229\u73e0\u5355\u6297\u7528\u4e8e\u665a\u671f\u5c3f\u8def\u4e0a\u76ae\u764c\u7684\u4e8c\u7ebf\u6cbb\u7597\u9002\u5e94\u8bc1\u662f\u57fa\u4e8e\u5168\u7403\u2162\u671f\u4e34\u5e8a\u7814\u7a76<span>KEYNOTE-045<\/span>\u7684\u7814\u7a76\u7ed3\u679c\uff0c\u8be5\u6cbb\u7597\u65b9\u6848\u5df2\u83b7\u5f97\u7f8e\u56fd<span>FDA<\/span>\u6279\u51c6\uff0c\u4f46\u76ee\u524d\u5c1a\u672a\u5f97\u5230\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u7684\u6279\u51c6\uff0c\u53ef\u5728\u4e0e\u60a3\u8005\u5145\u5206\u6c9f\u901a\u7684\u60c5\u51b5\u4e0b\u8003\u8651\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u65e2\u5f80\u9776\u5411\u6cbb\u7597\u5931\u8d25\u7684\u665a\u671f\u80be\u900f\u660e\u7ec6\u80de\u764c\uff0c\u4e5f\u53ef\u4ee5\u8003\u8651\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u963f\u6614\u66ff\u5c3c\u7528\u4e8e\u4e8c\u4e09\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u4f7f\u7528\u672c\u54c1\u4e4b\u524d\u5e94\u907f\u514d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u514d\u75ab\u6291\u5236\u5242\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u836f\u7269\u53ef\u80fd\u4f1a\u5f71\u54cd\u672c\u54c1\u7684\u836f\u6548\u5b66\u6d3b\u6027\u53ca\u7597\u6548\u3002\u4f46\u5728\u672c\u54c1\u5f00\u59cb\u7ed9\u836f\u540e\uff0c\u53ef\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u514d\u75ab\u4ecb\u5bfc\u6027\u4e0d\u826f\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u505c\u836f\uff0c\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u5224\u65ad\u5176\u4e0e\u836f\u7269\u7684\u76f8\u5173\u6027\u3002\u5982\u53d1\u751f<span>4<\/span>\u7ea7\u6216\u590d\u53d1\u6027<span>3<\/span>\u7ea7\uff0c\u8003\u8651\u4e0e\u5e15\u535a\u5229\u73e0\u5355\u6297\u76f8\u5173\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u867d\u7136\u8fdb\u884c\u6cbb\u7597\u8c03\u6574\u4f46\u4ecd\u6301\u7eed\u5b58\u5728<span>2<\/span>\u7ea7\u6216<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u6c38\u4e45\u6027\u505c\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u3002\u6709\u5173\u963f\u6614\u66ff\u5c3c\u7684\u5177\u4f53\u7528\u6cd5\u8be6\u89c1\u963f\u6614\u66ff\u5c3c\u90e8\u5206\u7684\u4ecb\u7ecd\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8001\u5e74\u60a3\u8005\uff08\u2265<span>65<\/span>\u5c81\uff09\u4e0e\u5e74\u8f7b\u60a3\u8005\uff08\uff1c<span>65<\/span>\u5c81\uff09\u5728\u5b89\u5168\u6027\u6216\u6709\u6548\u6027\u4e0a\u672a\u51fa\u73b0\u603b\u4f53\u7684\u5dee\u5f02\uff0c\u65e0\u9700\u5728\u8fd9\u4e00\u4eba\u7fa4\u4e2d\u8fdb\u884c\u8c03\u6574\uff0c\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u6570\u636e\u6709\u9650\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u5c1a\u672a\u5728\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u8fdb\u884c\u672c\u54c1\u7684\u76f8\u5173\u7814\u7a76\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u53ef\u5f15\u8d77\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u3002\u56e0\u4e3a\u4e0d\u826f\u53cd\u5e94\u53ef\u80fd\u5728\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u671f\u95f4\u6216\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u505c\u6b62\u540e\u7684\u4efb\u4f55\u65f6\u95f4\u53d1\u751f\uff0c\u5e94\u6301\u7eed\u8fdb\u884c\u60a3\u8005\u76d1\u6d4b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u6682\u505c\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\uff0c\u5e76\u7ed9\u4e88\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u975e\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6027\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u3002\u5fc5\u8981\u65f6\u4e0e\u76f8\u5173\u9886\u57df\u5b66\u79d1\u8fdb\u884c\u591a\u5b66\u79d1\u8bca\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u60a3\u8005\u63a5\u53d7\u514d\u75ab\u6291\u5236\u5242\u91cf\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u6cbb\u7597\u671f\u95f4\uff0c\u4e0d\u53ef\u91cd\u65b0\u4f7f\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e5d\u3001\u66ff\u96f7\u5229\u73e0\u5355\u6297 <span>Tislelizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u7528\u4e8e<span>PD-L1<\/span>\u9ad8\u8868\u8fbe\u7684\u542b\u94c2\u5316\u7597\u5931\u8d25\u5305\u62ec\u65b0\u8f85\u52a9\u6216\u8f85\u52a9\u5316\u7597<span>12<\/span>\u4e2a\u6708\u5185\u8fdb\u5c55\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u8be5\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\u8bc4\u4f30\uff0c\u7279\u522b\u662f\u80bf\u7624\u7ec4\u7ec7\u7684<span>PD-L1<\/span>\u8868\u8fbe\u60c5\u51b5\u68c0\u6d4b\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u53cd\u5e94\u53ca\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u91c7\u7528\u9759\u8109\u8f93\u6ce8\u7684\u65b9\u5f0f\u7ed9\u836f\uff0c\u9759\u8109\u8f93\u6ce8\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>200mg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\uff0c\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\u3002\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u5c1a\u65e0\u9488\u5bf9\u91cd\u5ea6\u809d\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u4ee5\u53ca\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u53ca\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u7684\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u8c28\u614e\u4f7f\u7528\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u54fa\u4e73\u671f\u5987\u5973\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u53ca\u672b\u6b21\u7ed9\u836f\u540e\u81f3\u5c11<span>5<\/span>\u4e2a\u6708\u5185\u505c\u6b62\u54fa\u4e73\u3002\u80b2\u9f84\u671f\u5987\u5973\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u671f\u95f4\uff0c\u4ee5\u53ca\u6700\u540e\u4e00\u6b21\u672c\u54c1\u7ed9\u836f\u540e\u81f3\u5c11<span>5<\/span>\u4e2a\u6708\u5185\u5e94\u91c7\u7528\u6709\u6548\u907f\u5b55\u63aa\u65bd\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56e0\u53ef\u80fd\u5e72\u6270\u672c\u54c1\u836f\u6548\u5b66\u6d3b\u6027\uff0c\u5e94\u907f\u514d\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002\u4f46\u662f\u5982\u679c\u4e3a\u4e86\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u540e\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u3001\u7279\u745e\u666e\u5229\u5355\u6297 <span>Toripalimab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c<\/span><\/b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\uff1a\u6ce8\u5c04\u6db2\uff1a<span>80mg<\/span>\uff08<span>2ml<\/span>\uff09<span>\/<\/span>\u74f6\u3001<span>240mg<\/span>\uff08<span>6ml<\/span>\uff09<span>\/<\/span>\u74f6<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u7528\u4e8e\u542b\u94c2\u5316\u7597\u5931\u8d25\u5305\u62ec\u65b0\u8f85\u52a9\u6216\u8f85\u52a9\u5316\u7597<span>12<\/span>\u4e2a\u6708\u5185\u8fdb\u5c55\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7279\u745e\u666e\u5229\u5355\u6297\u63a8\u8350\u5242\u91cf\u4e3a<span>3mg\/kg<\/span>\u3002\u9759\u8109\u8f93\u6ce8\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7279\u745e\u666e\u5229\u5355\u6297\u5728\u4e2d\u91cd\u5ea6\u809d\u80be\u529f\u80fd\u635f\u4f24\u4e2d\u4f7f\u7528\u7684\u5b89\u5168\u6027\u53ca\u6709\u6548\u6027\u5c1a\u672a\u5efa\u7acb\uff0c\u4e0d\u63a8\u8350\u7528\u4e8e\u4e2d\u91cd\u5ea6\u809d\u80be\u529f\u80fd\u635f\u4f24\u7684\u60a3\u8005\u3002\u8f7b\u5ea6\u809d\u80be\u529f\u80fd\u635f\u4f24\u7684\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8001\u5e74\u60a3\u8005\uff08\u2265<span>65<\/span>\u5c81\uff09\u5efa\u8bae\u5728\u533b\u751f\u7684\u6307\u5bfc\u4e0b\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\uff1b\u5c1a\u672a\u5efa\u7acb<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u53ca\u9752\u5c11\u5e74\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7279\u745e\u666e\u5229\u5355\u6297\u9996\u6b21\u9759\u8109\u8f93\u6ce8\u65f6\u95f4\u81f3\u5c11<span>60<\/span>\u5206\u949f\uff0c\u5982\u679c\u7b2c\u4e00\u6b21\u8f93\u6ce8\u8010\u53d7\u826f\u597d\uff0c\u5219\u7b2c\u4e8c\u6b21\u8f93\u6ce8\u65f6\u95f4\u53ef\u4ee5\u7f29\u77ed\u81f3<span>30<\/span>\u5206\u949f\uff0c\u5982\u679c\u60a3\u8005\u5bf9<span>30<\/span>\u5206\u949f\u7684\u8f93\u6ce8\u4e5f\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u540e\u7eed\u6240\u6709\u8f93\u6ce8\u5747\u53ef\u5728<span>30<\/span>\u5206\u949f\u5b8c\u6210\uff0c\u4e0d\u5f97\u91c7\u7528\u9759\u8109\u63a8\u6ce8\u6216\u5355\u6b21\u5feb\u901f\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u53ef\u53d1\u751f\u5728\u7279\u745e\u666e\u5229\u5355\u6297\u6cbb\u7597\u671f\u95f4\u53ca\u505c\u836f\u4ee5\u540e\uff0c\u53ef\u80fd\u7d2f\u53ca\u4efb\u4f55\u7ec4\u7ec7\u5668\u5b98\u3002\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u53ca\u6392\u9664\u5176\u4ed6\u539f\u56e0\u3002\u5927\u591a\u6570\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u662f\u53ef\u9006\u7684\uff0c\u5e76\u4e14\u53ef\u901a\u8fc7\u4e2d\u65ad\u7279\u745e\u666e\u5229\u5355\u6297\u3001\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u548c<span>\/<\/span>\u6216\u652f\u6301\u6cbb\u7597\u6765\u5904\u7406\u3002\u5bf9\u4e8e\u5927\u90e8\u5206<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u53ca\u67d0\u4e9b\u7279\u5b9a\u7684<span>2<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u9700\u6682\u505c\u7ed9\u836f\uff0c\u5bf9\u4e8e<span>4<\/span>\u7ea7\u53ca\u67d0\u4e9b\u7279\u5b9a\u7684<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u9700\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7279\u745e\u666e\u5229\u5355\u6297\u4e0d\u7ecf<span>CYP450<\/span>\u9176\u6216\u5176\u4ed6\u836f\u7269\u4ee3\u8c22\u9176\u4ee3\u8c22\uff0c\u56e0\u6b64\u5408\u5e76\u4f7f\u7528\u7684\u836f\u7269\u5bf9\u8fd9\u4e9b\u9176\u7684\u6291\u5236\u6216\u8bf1\u5bfc\u4f5c\u7528\u9884\u671f\u4e0d\u4f1a\u5f71\u54cd\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e00\u3001\u5965\u62c9\u5e15\u5229<span> Olaparib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>100mg<\/span>\u3001<span>150mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u643a\u5e26\u80da\u7cfb\u6216\u4f53\u7ec6\u80de<span>BRCA<\/span>\u7a81\u53d8\u4e14\u65e2\u5f80\u6cbb\u7597\uff08\u5305\u62ec\u4e00\u79cd\u65b0\u578b\u5185\u5206\u6ccc\u836f\u7269\uff09\u5931\u8d25\u7684\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u6210\u4eba\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5965\u62c9\u5e15\u5229\u7528\u4e8e\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u4e4b\u524d\uff0c\u5fc5\u987b\u91c7\u7528\u7ecf\u56fd\u5bb6\u836f\u76d1\u5c40\u6279\u51c6\u6216\u5176\u4ed6\u7ecf\u9a8c\u8bc1\u7684\u68c0\u6d4b\u65b9\u6cd5\uff0c\u786e\u8ba4\u60a3\u8005\u5b58\u5728\u80da\u7cfb\u548c<span>\/<\/span>\u6216\u4f53\u7ec6\u80de<span>BRCA1\/2<\/span>\u7a81\u53d8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a<span>300mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u5373\u6bcf\u5929\u603b\u5242\u91cf\u4e3a<span>600mg<\/span>\uff0c\u7528\u81f3\u75be\u75c5\u53d1\u751f\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.BRCA1\/2<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u7597\u7a0b\uff1a\u5efa\u8bae\u6301\u7eed\u6cbb\u7597\u76f4\u5230\u73b0\u6709\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u80fd\u8010\u53d7\u7684\u6bd2\u6027\u3002\u5bf9\u4e8e\u672a\u63a5\u53d7\u624b\u672f\u53bb\u52bf\u7684\u60a3\u8005\uff0c\u5e94\u5728\u6cbb\u7597\u671f\u95f4\u7ee7\u7eed\u4f7f\u7528\u4fc3\u9ec4\u4f53\u751f\u6210\u6fc0\u7d20\u91ca\u653e\u6fc0\u7d20\u7c7b\u4f3c\u7269\u8fdb\u884c\u836f\u7269\u53bb\u52bf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u6574\u7247\u541e\u670d\uff0c\u4e0d\u5e94\u5480\u56bc\u3001\u538b\u788e\u3001\u6eb6\u89e3\u6216\u63b0\u65ad\u836f\u7247\u3002\u5728\u8fdb\u9910\u6216\u7a7a\u8179\u65f6\u5747\u53ef\u670d\u7528\u3002\u5982\u679c\u60a3\u8005\u6f0f\u670d\u4e00\u5242\u836f\u7269\uff0c\u65e0\u9700\u8865\u670d\uff0c\u4ecd\u6309\u8ba1\u5212\u65f6\u95f4\u6b63\u5e38\u670d\u7528\u4e0b\u4e00\u5242\u91cf\uff0c\u5e76\u4e0d\u5f71\u54cd\u6574\u4f53\u7597\u6548\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5965\u62c9\u5e15\u5229\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u2265<span>20%<\/span>\uff09\u662f\uff1a\u8d2b\u8840\u3001\u6076\u5fc3\u3001\u75b2\u4e4f\uff08\u5305\u62ec\u4e4f\u529b\uff09\u3001\u5455\u5410\u3001\u8179\u6cfb\u3001\u5473\u89c9\u969c\u788d\u548c\u6d88\u5316\u4e0d\u826f\u3002\u6700\u5e38\u89c1\u7684\u751f\u5316\u68c0\u67e5\u5f02\u5e38\uff08\u2265<span>25%<\/span>\uff09\u662f\uff1a\u808c\u9150\u589e\u52a0\u3001\u7ea2\u7ec6\u80de\u5747\u6570\u4f53\u79ef\u5347\u9ad8\u3001\u8840\u7ea2\u86cb\u767d\u51cf\u4f4e\u3001\u6dcb\u5df4\u7ec6\u80de\u51cf\u4f4e\uff0c\u7edd\u5bf9\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u51cf\u4f4e\u3001\u8840\u5c0f\u677f\u51cf\u4f4e\u3002\u4e3a\u5904\u7406\u4e0d\u826f\u4e8b\u4ef6\uff0c\u6bd4\u5982\u8d2b\u8840\u3001\u6076\u5fc3\uff0c\u4e4f\u529b\u7b49\uff0c\u53ef\u8003\u8651\u4e2d\u65ad\u6cbb\u7597\u6216\u51cf\u91cf\u3002\u60a3\u8005\u5e94\u5728\u65e2\u5f80\u6297\u80bf\u7624\u6cbb\u7597\u5f15\u8d77\u7684\u8840\u6db2\u5b66\u6bd2\u6027\u6062\u590d\u4e4b\u540e\uff08\u8840\u7ea2\u86cb\u767d\u3001\u8840\u5c0f\u677f\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u6c34\u5e73\u5e94\u6062\u590d\u81f3\u2264<span>CTCAE l<\/span>\u7ea7\uff09\uff0c\u624d\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u3002\u5efa\u8bae\u5728\u57fa\u7ebf\u4ee5\u53ca\u6cbb\u7597\u7684\u524d<span>12<\/span>\u4e2a\u6708\u6bcf\u6708\u76d1\u6d4b\u5168\u8840\u7ec6\u80de\u8ba1\u6570\uff0c\u7136\u540e\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u671f\u95f4\u4efb\u4f55\u4e34\u5e8a\u663e\u8457\u53d8\u5316\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u9700\u8981\u51cf\u91cf\uff0c\u63a8\u8350\u5242\u91cf\u51cf\u81f3<span>250mg\/<\/span>\u6b21\uff08<span>1<\/span>\u7247<span>150mg<\/span>\u7247\u5242\uff0c<span>1<\/span>\u7247<span>100mg<\/span>\u7247\u5242\uff09\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u5373\u6bcf\u5929\u603b\u5242\u91cf\u4e3a<span>500mg<\/span>\u3002\u5982\u679c\u9700\u8981\u8fdb\u4e00\u6b65\u51cf\u91cf\uff0c\u5219\u63a8\u8350\u5242\u91cf\u51cf\u81f3<span>200mg\/<\/span>\u6b21\uff08<span>2<\/span>\u7247<span>100mg<\/span>\u7247\u5242\uff09\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u5373\u6bcf\u5929\u603b\u5242\u91cf\u4e3a<span>400mg<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u63a8\u8350\u672c\u54c1\u4e0e\u5f3a\u6548\u6216\u4e2d\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\u5408\u5e76\u4f7f\u7528\uff0c\u5982\u679c\u5fc5\u987b\u5408\u5e76\u4f7f\u7528\u5f3a\u6548\u6216\u4e2d\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\uff0c\u63a8\u8350\u5c06\u672c\u54c1\u5242\u91cf\u51cf\u81f3<span>100mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u5982\u679c\u5fc5\u987b\u5408\u5e76\u4f7f\u7528\u4e2d\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\uff0c\u63a8\u8350\u5c06\u672c\u54c1\u5242\u91cf\u51cf\u81f3<span>150mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p><b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><br \/>\n<\/span><\/b> <\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e73\u817a\u764c\u7528\u836f<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e00\u3001\u66f2\u59a5\u73e0\u5355\u6297<span> Trastuzumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u5242\uff1a<span>440mg<\/span>\uff08<span>20ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u590d\u53d1\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff1a\u672c\u54c1\u9002\u7528\u4e8e<span>HER2<\/span>\u9633\u6027\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff0c\u5355\u836f\u7528\u4e8e\u5df2\u63a5\u53d7\u8fc7\u591a\u4e2a\u5316\u7597\u65b9\u6848\u7684\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff1b\u4e0e\u7d2b\u6749\u9187\u6216\u591a\u897f\u4ed6\u8d5b\u7b49\u5316\u7597\u836f\u7269\u8054\u5408\uff0c\u7528\u4e8e\u672a\u63a5\u53d7\u5316\u7597\u7684\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e73\u817a\u764c\u8f85\u52a9\u6cbb\u7597\uff1a\u672c\u54c1\u9002\u7528\u4e8e\u80bf\u7624\u76f4\u5f84\uff1e<span>0.5cm<\/span>\u7684<span>HER2<\/span>\u9633\u6027\u53ef\u624b\u672f\u4e73\u817a\u764c\u7684\u8f85\u52a9\u6cbb\u7597\uff1b\u5bf9\u80bf\u7624\u76f4\u5f84\uff1c<span>0.5cm<\/span>\u6d78\u6da6\u6027\u4e73\u817a\u764c\uff0c\u9700\u8981\u7ed3\u5408\u5176\u4ed6\u56e0\u7d20\u8003\u8651\u662f\u5426\u4f7f\u7528\u3002\u66f2\u59a5\u73e0\u5355\u6297\u4e00\u822c\u4e0d\u4e0e\u84bd\u73af\u7c7b\u836f\u7269\u8054\u5408\u4f7f\u7528\uff0c\u4f46\u53ef\u5e8f\u8d2f\u4f7f\u7528\uff1b\u53ef\u4e0e\u7d2b\u6749\u7c7b\u53ca\u5176\u4ed6\uff08\u73af\u78f7\u9170\u80fa\u3001\u5361\u94c2\u7b49\uff09\u5316\u7597\u836f\u7269\u5408\u7528\uff0c\u8fd8\u53ef\u4e0e\u653e\u7597\u3001\u8f85\u52a9\u5185\u5206\u6ccc\u6cbb\u7597\u540c\u65f6\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e73\u817a\u764c\u65b0\u8f85\u52a9\u6cbb\u7597\uff1a\u4e0e\u5316\u7597\u8054\u5408\u8fdb\u884c\u65b0\u8f85\u52a9\u6cbb\u7597\uff0c\u7ee7\u4ee5\u8f85\u52a9\u6cbb\u7597\uff0c\u7528\u4e8e\u5c40\u90e8\u665a\u671f\uff08\u5305\u62ec\u708e\u6027\uff09\u7684<span>HER2<\/span>\u9633\u6027\u4e73\u817a\u764c\u3002\u672f\u540e\u7ee7\u7eed\u4f7f\u7528\u66f2\u59a5\u73e0\u5355\u6297\u603b\u7597\u7a0b\u4e3a<span>1<\/span>\u5e74\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5728\u63a5\u53d7\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u524d\uff0c\u5e94\u5728\u6709\u8d44\u8d28\u7684\u75c5\u7406\u5b9e\u9a8c\u5ba4\u8fdb\u884c<span>HER2<\/span>\u68c0\u6d4b\uff0c<span>HER2<\/span>\u9633\u6027\u60a3\u8005\u65b9\u53ef\u5e94\u7528\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e0e\u84bd\u73af\u7c7b\u836f\u7269\u540c\u671f\u5e94\u7528\u987b\u614e\u91cd\uff0c\u53ef\u80fd\u589e\u52a0\u5fc3\u810f\u6bd2\u6027\uff0c\u4e25\u91cd\u8005\u4f1a\u53d1\u751f\u5fc3\u529b\u8870\u7aed\uff0c\u5efa\u8bae\u5e8f\u8d2f\u4f7f\u7528\u6216\u5206\u522b\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u8981\u5bf9\u65e2\u5f80\u53f2\u3001\u4f53\u683c\u68c0\u67e5\u3001\u5fc3\u7535\u56fe\u3001\u8d85\u58f0\u5fc3\u52a8\u56fe<span>LVEF<\/span>\u57fa\u7ebf\u8bc4\u4f30\u540e\uff0c\u518d\u5f00\u59cb\u5e94\u7528\u66f2\u59a5\u73e0\u5355\u6297\uff0c\u4f7f\u7528\u671f\u95f4\u5e94\u6bcf<span>3<\/span>\u4e2a\u6708\u76d1\u6d4b<span>LVEF<\/span>\u3002\u82e5\u60a3\u8005\u6709\u65e0\u75c7\u72b6\u6027\u5fc3\u529f\u80fd\u4e0d\u5168\uff0c\u76d1\u6d4b\u9891\u7387\u5e94\u66f4\u9ad8\u3002\u51fa\u73b0\u4e0b\u5217\u60c5\u51b5\u65f6\uff1a\u6cbb\u7597\u4e2d\u82e5\u51fa\u73b0<span>LVEF<\/span>\uff1c<span>50%<\/span>\u6216\u4f4e\u4e8e\u6cbb\u7597\u524d<span>16%<\/span>\u4ee5\u4e0a\uff0c\u5e94\u6682\u505c\u6cbb\u7597\uff0c\u5e76\u8ddf\u8e2a\u76d1\u6d4b<span>LVEF<\/span>\u52a8\u6001\u53d8\u5316\uff0c\u76f4\u81f3\u6062\u590d\u5230<span>50%<\/span>\u4ee5\u4e0a\u65b9\u53ef\u7ee7\u7eed\u7528\u836f\u3002<span>LVEF<\/span>\u6301\u7eed\u4e0b\u964d\uff08\u5927\u4e8e<span>8<\/span>\u5468\uff09\uff0c\u6216\u8005\u4e09\u6b21\u4ee5\u4e0a\u56e0\u5fc3\u810f\u6bd2\u6027\u800c\u505c\u6b62\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\uff0c\u5e94\u6c38\u4e45\u505c\u7528\u66f2\u59a5\u73e0\u5355\u6297\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u8bc1\u5b9e\uff0c<span>HER2<\/span>\u9633\u6027\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\uff0c\u5728\u5176\u4ed6\u5316\u7597\u836f\u7269\u6216\u5185\u5206\u6ccc\u836f\u7269\u6cbb\u7597\u65f6\uff0c\u8054\u5408\u66f2\u59a5\u73e0\u5355\u6297\u53ef\u8fdb\u4e00\u6b65\u589e\u52a0\u4e34\u5e8a\u83b7\u76ca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u540e\u8fdb\u5c55\u7684<span>HER2<\/span>\u9633\u6027\u4e73\u817a\u764c\uff0c\u4e5f\u6709\u8bc1\u636e\u8bc1\u5b9e\u7ee7\u7eed\u4f7f\u7528\u66f2\u59a5\u73e0\u5355\u6297\u7684\u4e34\u5e8a\u83b7\u76ca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u6bcf\u5468\u7ed9\u836f\u65b9\u6848\u521d\u6b21\u8d1f\u8377\u5242\u91cf\uff1a\u5efa\u8bae\u672c\u54c1\u7684\u521d\u6b21\u8d1f\u8377\u91cf\u4e3a<span>4mg\/kg<\/span>\u3002\u9759\u8109\u8f93\u6ce8<span>90<\/span>\u5206\u949f\u4ee5\u4e0a\u3002\u7ef4\u6301\u5242\u91cf\uff1a\u5efa\u8bae\u672c\u54c1\u6bcf\u5468\u7528\u91cf\u4e3a<span>2mg\/kg<\/span>\u3002\u5982\u521d\u6b21\u8d1f\u8377\u91cf\u53ef\u8010\u53d7\uff0c\u5219\u6b64\u5242\u91cf\u53ef\u9759\u8109\u8f93\u6ce8<span>30<\/span>\u5206\u949f\u3002<span>3<\/span>\u5468\u7ed9\u836f\u65b9\u6848\u521d\u59cb\u8d1f\u8377\u5242\u91cf\u4e3a<span>8mg\/kg<\/span>\uff0c\u968f\u540e<span>6mg\/kg<\/span>\u6bcf\u4e09\u5468\u7ed9\u836f\u4e00\u6b21\u3002\u4e14\u91cd\u590d<span>6mg\/kg<\/span>\u6bcf\u4e09\u5468\u7ed9\u836f\u4e00\u6b21\u65f6\u8f93\u6ce8\u65f6\u95f4\u7ea6\u4e3a<span>90<\/span>\u5206\u949f\u3002\u5982\u679c\u60a3\u8005\u5728\u9996\u6b21\u8f93\u6ce8\u65f6\u8010\u53d7\u6027\u826f\u597d\uff0c\u540e\u7eed\u8f93\u6ce8\u53ef\u6539\u4e3a<span>30<\/span>\u5206\u949f\u3002\u914d\u7f6e\u540e\u7684\u6eb6\u6db2\u7a00\u91ca\u4e8e<span>250ml<\/span>\u7684<span>0.9%<\/span>\u6c2f\u5316\u94a0\u4e2d\uff0c\u4e0d\u53ef\u4f7f\u7528<span>5%<\/span>\u7684\u8461\u8404\u7cd6\uff08\u53ef\u4f7f\u86cb\u767d\u805a\u96c6\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u7597\u7a0b\uff1a\u4e73\u817a\u764c\u60a3\u8005\u672f\u540e\u4f7f\u7528\u66f2\u59a5\u73e0\u5355\u6297\u8f85\u52a9\u6cbb\u7597\u65f6\u95f4\u4e3a<span>1<\/span>\u5e74\uff0c\u4e0d\u5efa\u8bae\u5ef6\u957f\u6cbb\u7597\u65f6\u95f4\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u6069\u7f8e\u66f2\u59a5\u73e0\u5355\u6297<span> Trastuzumab Emtansine<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9488\u5242\uff1a<span>100mg\/<\/span>\u74f6\u3001<span>160mg\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5355\u836f\u9002\u7528\u4e8e\u63a5\u53d7\u4e86\u7d2b\u6749\u7c7b\u8054\u5408\u66f2\u59a5\u73e0\u5355\u6297\u4e3a\u57fa\u7840\u7684\u65b0\u8f85\u52a9\u6cbb\u7597\u540e\u4ecd\u6b8b\u5b58\u4fb5\u88ad\u6027\u75c5\u7076\u7684<span>HER2<\/span>\u9633\u6027\u65e9\u671f\u4e73\u817a\u764c\u60a3\u8005\u7684\u8f85\u52a9\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6069\u7f8e\u66f2\u59a5\u73e0\u5355\u6297\uff08<span>T-DM1<\/span>\uff09\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\u4e3a\u4e0d\u540c\u836f\u7269\uff0c\u7981\u6b62\u5728\u4e34\u5e8a\u5e94\u7528\u4e2d\u8fdb\u884c\u66ff\u6362\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a5\u53d7<span>T-DM1<\/span>\u8f85\u52a9\u6cbb\u7597\u7684\u60a3\u8005\u5e94\u7b26\u5408\u4ee5\u4e0b\u8981\u6c42\uff1a\uff08<span>1<\/span>\uff09\u5e94\u5728\u6709\u8d44\u8d28\u7684\u75c5\u7406\u5b9e\u9a8c\u5ba4\u901a\u8fc7<span>HER2<\/span>\u68c0\u6d4b\u786e\u8ba4\u4e3a<span>HER2<\/span>\u9633\u6027\u3002\uff08<span>2<\/span>\uff09\u5b8c\u6210\u4ee5\u66f2\u59a5\u73e0\u5355\u6297\uff08<span>H<\/span>\uff09\u548c\u7d2b\u6749\u7c7b\u4e3a\u57fa\u7840\u7684\u65b0\u8f85\u52a9\u6cbb\u7597\u65b9\u6848\u3002\uff08<span>3<\/span>\uff09\u65b0\u8f85\u52a9\u6cbb\u7597\u540e\u7684\u75c5\u7406\u8bc4\u4f30\u7ed3\u679c\u672a\u80fd\u8fbe\u5230\u75c5\u7406\u5b66\u5b8c\u5168\u7f13\u89e3\u3002\u75c5\u7406\u5b66\u5b8c\u5168\u7f13\u89e3\uff08<span>pCR<\/span>\uff09\u5b9a\u4e49\u4e3a\u4e73\u817a\u539f\u53d1\u7076\u65e0\u6d78\u6da6\u6027\u764c\u4e14\u533a\u57df\u6dcb\u5df4\u7ed3\u9634\u6027\uff0c\u5373<span>ypT0\/Tis ypN0<\/span>\u3002\u65b0\u8f85\u52a9\u6cbb\u7597\u540e\u4ec5\u6b8b\u4f59\u4e73\u817a\u8109\u7ba1\u5185\u80bf\u7624\u6216\u4ec5\u6dcb\u5df4\u7ed3\u5185\u6b8b\u4f59<span>ITC<\/span>\u5747\u4e0d\u80fd\u8bca\u65ad<span>pCR<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.T-DM1<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>3.6mg\/kg<\/span>\uff0c\u91c7\u7528\u9759\u8109\u8f93\u6ce8\u7ed9\u836f\uff0c\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff08<span>21<\/span>\u5929\u4e3a\u4e00\u4e2a\u5468\u671f\uff09\u3002\u65e9\u671f\u4e73\u817a\u764c\u60a3\u8005\u5e94\u63a5\u53d7\u5171<span>14<\/span>\u4e2a\u5468\u671f\u7684\u6cbb\u7597\uff0c\u9664\u975e\u75be\u75c5\u590d\u53d1\u6216\u51fa\u73b0\u65e0\u6cd5\u63a7\u5236\u7684\u6bd2\u6027\u3002\u53d1\u751f\u4e0d\u826f\u53cd\u5e94\u65f6\u5e94\u6839\u636e\u8bf4\u660e\u4e66\u53ca\u65f6\u8c03\u6574\u5242\u91cf\uff0c\u5242\u91cf\u964d\u4f4e\u65b9\u6848\u5982\u4e0b\u8868\u3002\u964d\u4f4e\u5242\u91cf\u540e\uff0c\u4e0d\u5e94\u518d\u589e\u52a0<span>T-DM1<\/span>\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<table class=\"MsoTableGrid\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"100%\" style=\"width:100.0%;border-collapse:collapse;border:none;\">\n<tbody>\n<tr>\n<td width=\"100%\" colspan=\"2\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8868<span>5<\/span>&emsp;\u6069\u7f8e\u66f2\u59a5\u73e0\u5355\u6297\u5242\u91cf\u964d\u4f4e\u65b9\u6848<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"50%\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u964d\u4f4e\u65b9\u6848<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"50%\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u6c34\u5e73<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"50%\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d77\u59cb\u5242\u91cf<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"50%\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.6mg\/kg<\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"50%\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7b2c\u4e00\u6b21\u964d\u4f4e\u5242\u91cf<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"50%\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3mg\/kg<\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"50%\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7b2c\u4e8c\u6b21\u964d\u4f4e\u5242\u91cf<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"50%\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.4mg\/kg<\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"50%\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9700\u8981\u8fdb\u4e00\u6b65\u964d\u4f4e\u5242\u91cf<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"50%\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ec8\u6b62\u6cbb\u7597<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u8981\u5bf9\u65e2\u5f80\u53f2\u3001\u4f53\u683c\u68c0\u67e5\u3001\u5fc3\u7535\u56fe\u3001\u8d85\u58f0\u5fc3\u52a8\u56fe<span>LVEF<\/span>\u57fa\u7ebf\u8bc4\u4f30\u540e\uff0c\u518d\u5f00\u59cb\u5e94\u7528<span>T-DM1<\/span>\uff0c\u4f7f\u7528\u671f\u95f4\u5e94\u6bcf<span>3<\/span>\u4e2a\u6708\u76d1\u6d4b<span>LVEF<\/span>\u3002\u82e5\u60a3\u8005\u6709\u65e0\u75c7\u72b6\u6027\u5fc3\u529f\u80fd\u4e0d\u5168\uff0c\u76d1\u6d4b\u9891\u7387\u5e94\u66f4\u9ad8\u3002\u51fa\u73b0\u4e0b\u5217\u60c5\u51b5\u65f6\uff1a\uff08<span>1<\/span>\uff09<span>LVEF<\/span>\uff1c<span>45%<\/span>\u5e94\u6682\u505c\u6cbb\u7597\uff0c<span>3<\/span>\u5468\u5185\u91cd\u590d\u8bc4\u4f30<span>LVEF<\/span>\u3002\u5982\u679c\u786e\u8ba4<span>LVEF<\/span>\uff1c<span>45%<\/span>\uff0c\u5e94\u7ec8\u6b62\u6cbb\u7597\u3002\uff08<span>2<\/span>\uff09<span>LVEF<\/span>\u4e3a<span>45%<\/span>\u81f3\uff1c<span>50%<\/span>\uff0c\u4e14\u76f8\u5bf9\u57fa\u7ebf\u4e0b\u964d\u2265<span>10%<\/span>\uff0c\u5e94\u6682\u505c\u6cbb\u7597\uff0c\u5e76\u5728<span>3<\/span>\u5468\u5185\u91cd\u590d\u8bc4\u4f30<span>LVEF<\/span>\u3002\u5982\u679c<span>LVEF<\/span>\u4ecd\u4e3a\uff1c<span>50%<\/span>\uff0c\u5e76\u4e14\u76f8\u5bf9\u57fa\u7ebf\u672a\u6062\u590d\u81f3\uff1c<span>10%<\/span>\uff0c\u5e94\u7ec8\u6b62\u6cbb\u7597\u3002\uff08<span>3<\/span>\uff09<span>LVEF<\/span>\u4e3a<span>45%<\/span>\u81f3\uff1c<span>50%<\/span>\uff0c\u76f8\u5bf9\u57fa\u7ebf\u4e0b\u964d\uff1c<span>10%<\/span>\uff0c\u53ef\u7ee7\u7eed\u6cbb\u7597\uff0c\u5e76\u5728<span>3<\/span>\u5468\u5185\u91cd\u590d\u8bc4\u4f30<span>LVEF<\/span>\u3002\uff08<span>4<\/span>\uff09<span>LVEF<\/span>\u2265<span>50%<\/span>\uff0c\u53ef\u7ee7\u7eed\u8fdb\u884c\u6cbb\u7597\u3002\uff08<span>5<\/span>\uff09\u75c7\u72b6\u6027\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\uff0c<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u5de6\u5fc3\u5ba4\u6536\u7f29\u529f\u80fd\u969c\u788d\u6216<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u5fc3\u529b\u8870\u7aed\uff0c\u6216<span>2<\/span>\u7ea7\u5fc3\u529b\u8870\u7aed\u4f34\u6709<span>LVEF<\/span>\uff1c<span>45%<\/span>\uff0c\u5e94\u7ec8\u6b62\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u5728\u6bcf\u6b21<span>T-DM1<\/span>\u7ed9\u836f\u4e4b\u524d\u76d1\u6d4b\u8840\u5c0f\u677f\u8ba1\u6570\uff1a\uff08<span>1<\/span>\uff09\u5982\u679c\u8ba1\u5212\u6cbb\u7597\u65e5\u65f6\u4e3a<span>2<\/span>\uff5e<span>3<\/span>\u7ea7\uff08<span>25<\/span>\uff5e<span>75<\/span>\uff09\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff0c\u5219\u5e94\u5ef6\u8fdf\u81f3\u8840\u5c0f\u677f\u8ba1\u6570\u6062\u590d\u81f3\u2264<span>1<\/span>\u7ea7\uff08\u2265<span>75<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff09\u540e\u4ee5\u76f8\u540c\u5242\u91cf\u6c34\u5e73\u8fdb\u884c\u6cbb\u7597\u3002\u5982\u679c\u60a3\u8005\u56e0\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u9700\u5ef6\u8fdf\u4e24\u6b21\u7ed9\u836f\uff0c\u5e94\u8003\u8651\u964d\u4f4e\u4e00\u4e2a\u5242\u91cf\u6c34\u5e73\u8fdb\u884c\u6cbb\u7597\u3002\uff08<span>2<\/span>\uff09\u5982\u679c\u8840\u5c0f\u677f\u964d\u4f4e\u8fbe\u5230<span>4<\/span>\u7ea7\uff08\uff1c<span>25<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff09\uff0c\u5219\u5e94\u5ef6\u8fdf\u81f3\u8840\u5c0f\u677f\u8ba1\u6570\u6062\u590d\u81f3\u2264<span>1<\/span>\u7ea7\uff08\u2265<span>75<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff09\u540e\u964d\u4f4e\u4e00\u4e2a\u5242\u91cf\u6c34\u5e73\u8fdb\u884c\u6cbb\u7597\u3002\uff08<span>3<\/span>\uff09\u5bf9\u4e8e\u51fa\u73b0\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\uff08\u8840\u5c0f\u677f\u8ba1\u6570\uff1c<span>100<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff09\u7684\u60a3\u8005\u548c\u6b63\u5728\u63a5\u53d7\u6297\u51dd\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u5728\u672c\u54c1\u6cbb\u7597\u671f\u95f4\uff0c\u5e94\u8be5\u5bf9\u5176\u8fdb\u884c\u5bc6\u5207\u76d1\u6d4b\u3002\uff08<span>4<\/span>\uff09\u7edd\u5927\u591a\u6570\u8840\u5c0f\u677f\u51cf\u5c11\u53ef\u4ee5\u6839\u636e\u8bf4\u660e\u4e66\u8fdb\u884c\u6682\u505c\u6216\u51cf\u91cf\u53ca\u505c\u836f\u5904\u7406\u540e\u6062\u590d\u3002\u7ecf\u5e38\u89c4\u5347\u8840\u5c0f\u677f\u6cbb\u7597\u540e\u6548\u679c\u4e0d\u4f73\u65f6\uff0c\u5e94\u5c3d\u65e9\u8bf7\u8840\u6db2\u79d1\u4e13\u79d1\u533b\u5e08\u4f1a\u8bca\uff0c\u5fc5\u8981\u65f6\u7ed9\u4e88\u9488\u5bf9\u6027\u7684\u68c0\u67e5\u5982\u9aa8\u9ad3\u7a7f\u523a\u3001\u8840\u5c0f\u677f\u751f\u6210\u7d20\u6297\u4f53\u3001\u8840\u5c0f\u677f\u6297\u4f53\u68c0\u6d4b\u7b49\uff0c\u660e\u786e\u53ef\u80fd\u7684\u75c5\u56e0\u540e\u7ed9\u4e88\u5bf9\u75c7\u5904\u7406\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e24\u9879\u56fd\u9645\u591a\u4e2d\u5fc3\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u63d0\u793a\uff1a<span>T-DM1<\/span>\u7528\u4e8e\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u5931\u8d25\u7684<span>HER2<\/span>\u9633\u6027\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\uff0c\u5bf9\u6bd4\u62c9\u5e15\u66ff\u5c3c\u8054\u5408\u5361\u57f9\u4ed6\u6ee8\u548c\u533b\u5e08\u9009\u62e9\u7684\u6cbb\u7597\u65b9\u6848\u5747\u53ef\u663e\u8457\u5ef6\u957f\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u548c\u603b\u751f\u5b58\u671f\u3002<span>T-DM1<\/span>\u53ef\u4f5c\u4e3a<span>HER2<\/span>\u9633\u6027\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\u4e8c\u7ebf\u53ca\u540e\u7ebf\u7684\u6cbb\u7597\u9009\u62e9\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e09\u3001\u5e15\u59a5\u73e0\u5355\u6297<span> Pertuzumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>420mg<\/span>\uff08<span>14ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e73\u817a\u764c\u8f85\u52a9\u6cbb\u7597\uff1a\u672c\u54c1\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\u548c\u5316\u7597\u8054\u5408\uff0c\u7528\u4e8e\u9ad8\u590d\u53d1\u98ce\u9669\u7684<span>HER2<\/span>\u9633\u6027\u65e9\u671f\u4e73\u817a\u764c\u60a3\u8005\u7684\u8f85\u52a9\u6cbb\u7597\u3002\u5e15\u59a5\u73e0\u5355\u6297\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\u8054\u5408\uff0c\u8fd8\u53ef\u4e0e\u8f85\u52a9\u5185\u5206\u6ccc\u6cbb\u7597\u540c\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e73\u817a\u764c\u65b0\u8f85\u52a9\u6cbb\u7597\uff1a\u672c\u54c1\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\u548c\u5316\u7597\u8054\u5408\uff0c\u7528\u4e8e<span>HER2<\/span>\u9633\u6027\u3001\u5c40\u90e8\u665a\u671f\u3001\u708e\u6027\u6216\u65e9\u671f\u4e73\u817a\u764c\u60a3\u8005\uff08\u80bf\u7624\u76f4\u5f84\uff1e<span>2cm<\/span>\u6216\u6dcb\u5df4\u7ed3\u9633\u6027\uff09\u7684\u65b0\u8f85\u52a9\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u590d\u53d1\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u6cbb\u7597\uff1a\u672c\u54c1\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\u548c\u7d2b\u6749\u7c7b\u5316\u7597\u836f\u8054\u5408\u7528\u4e8e<span>HER2<\/span>\u9633\u6027\u3001\u8f6c\u79fb\u6027\u6216\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u590d\u53d1\u6027\u4e73\u817a\u764c\u60a3\u8005\u3002\u60a3\u8005\u65e2\u5f80\u9488\u5bf9\u8f6c\u79fb\u6027\u75be\u75c5\u5e94\u672a\u63a5\u53d7\u8fc7\u6297<span>HER2<\/span>\u6cbb\u7597\uff0c\u6216\u65e2\u5f80\u8f85\u52a9\u6cbb\u7597\u9636\u6bb5\u63a5\u53d7\u8fc7\u6297<span>HER2<\/span>\u6cbb\u7597\uff0c\u505c\u6b62\u6297<span>HER2<\/span>\u6cbb\u7597\u540e\u4e00\u5e74\u4ee5\u4e0a\u590d\u53d1\u8f6c\u79fb\u7684\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u63a5\u53d7\u5e15\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u75c5\u7076\u7ec4\u7ec7\u6807\u672c\uff0c\u5e94\u5728\u6709\u8d44\u8d28\u7684\u75c5\u7406\u5b9e\u9a8c\u5ba4\u8fdb\u884c<span>HER2<\/span>\u68c0\u6d4b\uff0c<span>HER2<\/span>\u9633\u6027\u60a3\u8005\u65b9\u53ef\u5e94\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5e15\u59a5\u73e0\u5355\u6297\u7684\u63a8\u8350\u8d77\u59cb\u5242\u91cf\u4e3a<span>840mg<\/span>\uff0c\u9759\u8109\u8f93\u6ce8<span>60<\/span>\u5206\u949f\uff0c\u6b64\u540e\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u7ed9\u836f\u5242\u91cf\u4e3a<span>420mg<\/span>\uff0c\u8f93\u6ce8\u65f6\u95f4<span>30<\/span>\uff5e<span>60<\/span>\u5206\u949f\u3002\u5728\u6bcf\u6b21\u5b8c\u6210\u5e15\u59a5\u73e0\u5355\u6297\u8f93\u6db2\u540e\uff0c\u5efa\u8bae\u89c2\u5bdf<span>30<\/span>\uff5e<span>60<\/span>\u5206\u949f\u3002\u89c2\u5bdf\u65f6\u95f4\u7ed3\u675f\u540e\u65b9\u53ef\u7ed9\u4e88\u540e\u7eed\u66f2\u59a5\u73e0\u5355\u6297\u6216\u5316\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5e15\u59a5\u73e0\u5355\u6297\u548c\u66f2\u59a5\u73e0\u5355\u6297\u5fc5\u987b\u5e8f\u8d2f\u7ed9\u836f\uff0c\u4f46\u5148\u540e\u987a\u5e8f\u5747\u53ef\u3002\u5728\u4e0e\u5e15\u59a5\u73e0\u5355\u6297\u8054\u5408\u4f7f\u7528\u65f6\uff0c\u66f2\u59a5\u73e0\u5355\u6297\u7684\u4f7f\u7528\u5efa\u8bae\u91c7\u7528\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\u4f7f\u7528\uff1b\u5bf9\u4e8e\u63a5\u53d7\u7d2b\u6749\u7c7b\u836f\u7269\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u5e15\u59a5\u73e0\u5355\u6297\u548c\u66f2\u59a5\u73e0\u5355\u6297\u7ed9\u836f\u5e94\u5148\u4e8e\u7d2b\u6749\u7c7b\u836f\u7269\uff1b\u5bf9\u4e8e\u63a5\u53d7\u84bd\u73af\u7c7b\u836f\u7269\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u5e15\u59a5\u73e0\u5355\u6297\u548c\u66f2\u59a5\u73e0\u5355\u6297\u5e94\u5728\u5b8c\u6210\u5b8c\u6574\u84bd\u73af\u7c7b\u836f\u7269\u6cbb\u7597\u65b9\u6848\u540e\u7ed9\u4e88\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5e15\u59a5\u73e0\u5355\u6297\u7a00\u91ca\u4e8e<span>250ml<\/span>\u7684<span>0.9%<\/span>\u6c2f\u5316\u94a0\u4e2d\uff0c\u4e0d\u5f97\u4f7f\u7528<span>5%<\/span>\u8461\u8404\u7cd6\u6eb6\u6db2\u7a00\u91ca\u5e15\u59a5\u73e0\u5355\u6297\uff0c\u540c\u65f6\u4e5f\u4e0d\u5f97\u4e0e\u5176\u4ed6\u836f\u7269\u6df7\u5408\u6216\u7a00\u91ca\u3002\u914d\u7f6e\u597d\u540e\u5e94\u8f7b\u8f7b\u5012\u7f6e\u8f93\u6db2\u888b\u4ee5\u6df7\u5408\u6eb6\u6db2\uff0c\u907f\u514d\u8d77\u6ce1\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u672f\u524d\u65b0\u8f85\u52a9\u6cbb\u7597\u65f6\uff0c\u5efa\u8bae\u60a3\u8005\u63a5\u53d7<span>4<\/span>\uff5e<span>6<\/span>\u4e2a\u5468\u671f\u7684\u542b\u5e15\u59a5\u73e0\u5355\u6297\u8054\u5408\u6cbb\u7597\u3002\u7528\u4e8e\u8f85\u52a9\u6cbb\u7597\u65f6\uff08\u624b\u672f\u540e\uff09\uff0c\u4f5c\u4e3a\u65e9\u671f\u4e73\u817a\u764c\u5b8c\u6574\u6cbb\u7597\u65b9\u6848\u7684\u4e00\u90e8\u5206\uff08\u5305\u62ec\u6807\u51c6\u7684\u84bd\u73af\u7c7b\u548c<span>\/<\/span>\u6216\u7d2b\u6749\u7c7b\u5316\u7597\uff09\uff0c\u5e15\u59a5\u73e0\u5355\u6297\u5e94\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\u8054\u5408\u4f7f\u7528\uff0c\u7597\u7a0b\u4e00\u5e74\u3002\u7528\u4e8e\u590d\u53d1\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u6cbb\u7597\u65f6\uff0c\u5e15\u59a5\u73e0\u5355\u6297\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\u548c\u7d2b\u6749\u7c7b\u5316\u7597\u836f\u7269\u8054\u5408\u4f7f\u7528\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u63a7\u5236\u7684\u6bd2\u6027\uff0c\u5373\u4f7f\u7ec8\u6b62\u5316\u7597\u540e\uff0c\u5e15\u59a5\u73e0\u5355\u6297\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\u7684\u6cbb\u7597\u4e5f\u53ef\u7ee7\u7eed\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5728\u9996\u6b21\u63a5\u53d7\u5e15\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u4e4b\u524d\u8bc4\u4f30<span>LVEF<\/span>\uff0c\u5e76\u5728\u6cbb\u7597\u671f\u95f4\u4e88\u4ee5\u5b9a\u671f\u8bc4\u4f30\uff08\u7ea6<span>4<\/span>\u4e2a\u5468\u671f\u89c1\u8868<span>6<\/span>\uff09\uff0c\u4ee5\u786e\u4fdd<span>LVEF<\/span>\u5728\u6b63\u5e38\u8303\u56f4\u5185\uff08\uff1e<span>50%<\/span>\uff09\u3002\u5982\u679c<span>LVEF<\/span>\u4e0b\u964d\u5e76\u672a\u6539\u5584\uff0c\u6216\u8005\u5728\u540e\u7eed\u8bc4\u4f30\u4e2d\u8fdb\u4e00\u6b65\u4e0b\u964d\uff0c\u5e94\u8003\u8651\u505c\u7528\u5e15\u59a5\u73e0\u5355\u6297\u53ca\u66f2\u59a5\u73e0\u5355\u6297\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e34\u5e8a\u7814\u7a76\u8bc1\u5b9e\uff0c<span>HER2<\/span>\u9633\u6027\u590d\u53d1\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\uff0c\u5728\u5176\u4ed6\u5316\u7597\u836f\u7269\u6216\u5185\u5206\u6ccc\u836f\u7269\u6cbb\u7597\u65f6\uff0c\u8054\u5408\u5e15\u59a5\u73e0\u5355\u6297\u548c\u66f2\u59a5\u73e0\u5355\u6297\u53ef\u8fdb\u4e00\u6b65\u589e\u52a0\u4e34\u5e8a\u83b7\u76ca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u59a5\u73e0\u5355\u6297\u7528\u4e8e<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u548c\u9752\u5c11\u5e74\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5c1a\u672a\u786e\u5b9a\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8868<span>6<\/span>&emsp;\u5de6\u5fc3\u5ba4\u529f\u80fd\u4e0d\u5168\u7684\u5e15\u59a5\u73e0\u5355\u6297\u5242\u91cf\u63a8\u8350<span><\/span><\/span><\/b>\n<\/p>\n<div align=\"center\">\n<table class=\"MsoNormalTable ke-zeroborder\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"1115\" style=\"border-collapse:collapse;\">\n<tbody>\n<tr>\n<td width=\"175\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n\t\t\t\t\t<a name=\"OLE_LINK93\"><\/a><a name=\"OLE_LINK94\"><\/a> <\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"> <\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"175\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u524d\u7684<span>LVEF<\/span>\uff1a<span><\/span><\/span><\/b>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"175\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">LVEF<\/span><\/b><b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76d1\u6d4b\u95f4\u9694\uff1a<span><\/span><\/span><\/b>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"295\" colspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5f53<span>LVEF<\/span>\u4e0b\u964d\u81f3\u4ee5\u4e0b\u6c34\u5e73\uff0c\u5e15\u59a5\u73e0\u5355\u6297\u548c\u66f2\u59a5\u73e0\u5355\u6297\u81f3\u5c11\u6682\u505c<span>3<\/span>\u5468\uff1a<span><\/span><\/span><\/b>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"295\" colspan=\"3\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c<span>LVEF<\/span>\u7f13\u89e3\u81f3\u4ee5\u4e0b\u6c34\u5e73\uff0c\u5219\u5728<span>3<\/span>\u5468\u540e\u91cd\u65b0\u4f7f\u7528\u5e15\u59a5\u73e0\u5355\u6297\u548c\u66f2\u59a5\u73e0\u5355\u6297\uff1a<span><\/span><\/span><\/b>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"175\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f6c\u79fb\u6027\u4e73\u817a\u764c<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"175\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2265<span>50%<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"175\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea6<span>12<\/span>\u5468<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"148\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1c<span>40%<\/span>\u6216<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"148\" colspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">40%<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>45%<\/span>\uff0c\u4e0e\u6cbb\u7597\u524d\u7edd\u5bf9\u6570\u503c\u76f8\u6bd4\u964d\u4f4e\u4e86\u2265<span>10%<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"147\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1e<span>45%<\/span>\u6216<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"147\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">40%<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>45%<\/span>\uff0c\u4e0e\u6cbb\u7597\u524d\u7edd\u5bf9\u6570\u503c\u76f8\u6bd4\u964d\u4f4e\u4e86\uff1c<span>10%<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"175\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e9\u671f\u4e73\u817a\u764c<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"175\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2265<span>55%<sup>*<\/sup><\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"175\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea6<span>12<\/span>\u5468\uff08\u5728\u65b0\u8f85\u52a9\u6cbb\u7597\u671f\u95f4\u76d1\u6d4b\u4e00\u6b21\uff09<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"296\" colspan=\"3\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1c<span>50%<\/span>\uff0c\u4e14\u4e0e\u6cbb\u7597\u524d\u7edd\u5bf9\u6570\u503c\u76f8\u6bd4\u964d\u4f4e\u4e86\u2265<span>10%<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"147\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2265<span>50%<\/span>\u6216<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"147\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0e\u6cbb\u7597\u524d\u7edd\u5bf9\u6570\u503c\u76f8\u6bd4\u964d\u4f4e\u4e86\uff1c<span>10%<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"175\" style=\"border:none;\">\n\t\t\t\t<\/td>\n<td width=\"175\" style=\"border:none;\">\n\t\t\t\t<\/td>\n<td width=\"175\" style=\"border:none;\">\n\t\t\t\t<\/td>\n<td width=\"148\" style=\"border:none;\">\n\t\t\t\t<\/td>\n<td width=\"147\" style=\"border:none;\">\n\t\t\t\t<\/td>\n<td width=\"1\" style=\"border:none;\">\n\t\t\t\t<\/td>\n<td width=\"147\" style=\"border:none;\">\n\t\t\t\t<\/td>\n<td width=\"147\" style=\"border:none;\">\n\t\t\t\t<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<sup><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">*<\/span><\/sup><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u63a5\u53d7\u84bd\u73af\u7c7b\u836f\u7269\u5316\u7597\u7684\u60a3\u8005\uff0c\u5728\u5b8c\u6210\u84bd\u73af\u7c7b\u836f\u7269\u5316\u7597\u4e4b\u540e\u548c\u5728\u9996\u6b21\u5e15\u59a5\u73e0\u5355\u6297\u548c\u66f2\u59a5\u73e0\u5355\u6297\u4e4b\u524d\uff0c<span>LVEF<\/span>\u503c\u9700\u2265<span>50%<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56db\u3001\u4f0a\u5c3c\u59a5\u5355\u6297<span> Inetetamab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9488\u5242\uff1a<span>50mg\/<\/span>\u652f<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u9002\u7528\u4e8e<span>HER2<\/span>\u9633\u6027\uff0c\u4e0e\u957f\u6625\u745e\u6ee8\u8054\u5408\u6cbb\u7597\u5df2\u63a5\u53d7\u8fc7<span>1<\/span>\u4e2a\u6216\u591a\u4e2a\u5316\u7597\u65b9\u6848\u7684\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u63a5\u53d7\u4f0a\u5c3c\u59a5\u5355\u6297\u6cbb\u7597\u524d\uff0c\u5e94\u5728\u6709\u8d44\u8d28\u7684\u75c5\u7406\u5b9e\u9a8c\u5ba4\u8fdb\u884c<span>HER2<\/span>\u68c0\u6d4b\uff0c<span>HER2<\/span>\u9633\u6027\u60a3\u8005\u65b9\u53ef\u5e94\u7528\u4f0a\u5c3c\u59a5\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u5c3c\u59a5\u5355\u6297\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76\u4e2d\u4f7f\u7528\u4e86\u5355\u5468\u7528\u836f\u65b9\u6848\u548c\u4e09\u5468\u7528\u836f\u65b9\u6848\u3002\u5355\u5468\u7528\u836f\u65b9\u6848\u4e2d\u4f0a\u5c3c\u59a5\u5355\u6297\u7684\u63a8\u8350\u521d\u59cb\u8d1f\u8377\u5242\u91cf\u4e3a<span>4mg\/kg<\/span>\uff0c\u9759\u8109\u6ef4\u6ce8<span>90<\/span>\u5206\u949f\u4ee5\u4e0a\uff1b\u7ef4\u6301\u5242\u91cf\u4e3a<span>2mg\/kg<\/span>\uff0c\u6bcf\u5468\u4e00\u6b21\u3002\u4e09\u5468\u7528\u836f\u65b9\u6848\u4e2d\u4f0a\u5c3c\u59a5\u5355\u6297\u7684\u63a8\u8350\u521d\u59cb\u8d1f\u8377\u5242\u91cf\u4e3a<span>8mg\/kg<\/span>\uff0c\u9759\u8109\u6ef4\u6ce8<span>90<\/span>\u5206\u949f\u4ee5\u4e0a\uff1b\u7ef4\u6301\u5242\u91cf\u4e3a<span>6mg\/kg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0e\u84bd\u73af\u7c7b\u836f\u7269\u540c\u671f\u5e94\u7528\u987b\u614e\u91cd\uff0c\u53ef\u80fd\u589e\u52a0\u5fc3\u810f\u6bd2\u6027\uff0c\u4e25\u91cd\u8005\u4f1a\u53d1\u751f\u5fc3\u529b\u8870\u7aed\uff0c\u5e94\u5e8f\u8d2f\u4f7f\u7528\u6216\u5206\u522b\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f7f\u7528\u4f0a\u5c3c\u59a5\u5355\u6297\u6cbb\u7597\u524d\uff0c\u5e94\u8fdb\u884c\u75c5\u53f2\u3001\u4f53\u68c0\u3001\u5fc3\u7535\u56fe\u3001\u8d85\u58f0\u5fc3\u52a8\u56fe<span>LVEF<\/span>\u57fa\u7ebf\u8bc4\u4f30\uff0c\u4f7f\u7528\u671f\u95f4\u5e94\u6bcf<span>3<\/span>\u4e2a\u6708\u76d1\u6d4b<span>LVEF<\/span>\u3002\u82e5<span>LVEF<\/span>\u503c\u76f8\u5bf9\u57fa\u7ebf\u4e0b\u964d\uff1e<span>10%<\/span>\uff0c\u5e76\u4e14\u4e0b\u964d\u81f3<span>50%<\/span>\u4ee5\u4e0b\uff0c\u5219\u5e94\u6682\u505c\u4f7f\u7528\u4f0a\u5c3c\u59a5\u5355\u6297\uff0c\u5e76\u5728\u7ea6<span>3<\/span>\u5468\u5185\u91cd\u590d\u8bc4\u4f30<span>LVEF<\/span>\u3002\u82e5<span>LVEF<\/span>\u65e0\u6539\u5584\u6216\u8fdb\u4e00\u6b65\u4e0b\u964d\uff0c\u6216\u51fa\u73b0\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\uff0c\u5219\u5f3a\u70c8\u5efa\u8bae\u7ec8\u6b62\u4f0a\u5c3c\u59a5\u5355\u6297\u7528\u836f\u3002\u5bf9\u4e8e\u53d1\u751f\u65e0\u75c7\u72b6\u5fc3\u529f\u80fd\u4e0d\u5168\u7684\u60a3\u8005\uff0c\u5e94\u9891\u7e41\u76d1\u6d4b\uff08\u5982\u6bcf<span>6<\/span>\uff5e<span>8<\/span>\u5468\u4e00\u6b21\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u63a8\u8350\u5408\u5e76\u6709\u4ee5\u4e0b\u75be\u75c5\u7684\u60a3\u8005\u4f7f\u7528\u672c\u54c1\uff1a\uff08<span>1<\/span>\uff09\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\u3002\uff08<span>2<\/span>\uff09\u9ad8\u5371\u3001\u672a\u63a7\u5236\u5fc3\u5f8b\u5931\u5e38\u3002\uff08<span>3<\/span>\uff09\u9700\u8981\u836f\u7269\u6cbb\u7597\u7684\u5fc3\u7ede\u75db\u3002\uff08<span>4<\/span>\uff09\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u5fc3\u74e3\u819c\u75be\u75c5\u3002\uff08<span>5<\/span>\uff09\u5fc3\u7535\u56fe\u63d0\u793a\u900f\u58c1\u6027\u5fc3\u808c\u6897\u6b7b\u3002\uff08<span>6<\/span>\uff09\u63a7\u5236\u4e0d\u4f73\u7684\u9ad8\u8840\u538b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f7f\u7528\u4f0a\u5c3c\u59a5\u5355\u6297\u53d1\u751f\u547c\u5438\u56f0\u96be\u6216\u8005\u4e34\u5e8a\u663e\u8457\u7684\u4f4e\u8840\u538b\u65f6\u5e94\u4e2d\u65ad\u8f93\u6ce8\uff0c\u540c\u65f6\u7ed9\u4e88\u76f8\u5e94\u836f\u7269\u6cbb\u7597\uff0c\u5305\u62ec\u80be\u4e0a\u817a\u7d20\u3001\u7cd6\u76ae\u8d28\u6fc0\u7d20\u3001\u82ef\u6d77\u62c9\u660e\u3001\u652f\u6c14\u7ba1\u6269\u5f20\u5242\u548c\u6c27\u6c14\u7b49\u3002\u53d1\u751f\u4e25\u91cd\u548c\u5371\u53ca\u751f\u547d\u7684\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\u7684\u60a3\u8005\u5e94\u6c38\u4e45\u505c\u6b62\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><a name=\"_Hlk44948457\"><\/a><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u5c3c\u59a5\u5355\u6297\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u663e\u793a\uff0c\u4f0a\u5c3c\u59a5\u5355\u6297\u8054\u5408\u957f\u6625\u745e\u6ee8\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7<span>1<\/span>\u4e2a\u6216\u591a\u4e2a\u5316\u7597\u65b9\u6848\u7684<span>HER2<\/span>\u9633\u6027\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\uff0c\u5bf9\u6bd4\u957f\u6625\u745e\u6ee8\u53ef\u663e\u8457\u5ef6\u957f\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08<span>39.1<\/span>\u5468<i><span>vs<\/span><\/i><span>14.0<\/span>\u5468\uff0c<span>HR<\/span>\uff1d<span>0.24<\/span>\uff0c<i><span>p<\/span><\/i>\uff1c<span>0.0001<\/span>\uff09\uff0c\u4f7f\u5f97\u60a3\u8005\u4e34\u5e8a\u83b7\u76ca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e94\u3001\u62c9\u5e15\u66ff\u5c3c<span> Lapatinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>0.25g<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u62c9\u5e15\u66ff\u5c3c\u4e0e\u5361\u57f9\u4ed6\u6ee8\u8054\u7528\uff0c\u9002\u7528\u4e8e<span>HER2<\/span>\u8fc7\u8868\u8fbe\u4e14\u65e2\u5f80\u63a5\u53d7\u8fc7\u5305\u62ec\u84bd\u73af\u7c7b\u3001\u7d2b\u6749\u7c7b\u548c\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u7684\u665a\u671f\u6216\u8005\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8003\u8651\u4f7f\u7528\u672c\u836f\u7684\u60a3\u8005\u9700\u8fdb\u884c\u7ec4\u7ec7\u6807\u672c\uff08\u539f\u53d1\u7076\u6216\u8f6c\u79fb\u7076\uff09\u7684<span>HER2<\/span>\u68c0\u6d4b\uff0c\u65e0\u8bba\u662f\u539f\u53d1\u7076\u8fd8\u662f\u8f6c\u79fb\u7076\uff0c<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">HER2<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9633\u6027\u60a3\u8005\u65b9\u53ef\u5e94\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4ec5\u9002\u7528\u4e8e\u590d\u53d1\u8f6c\u79fb\u60a3\u8005\uff0c\u539f\u5219\u4e0a\u4e0d\u63a8\u8350\u4e00\u7ebf\u4f7f\u7528\uff0c\u9664\u975e\u662f\u60a3\u8005\u6709\u66f2\u59a5\u73e0\u5355\u6297\u7684\u7981\u5fcc\u8bc1\u6216\u53c2\u52a0\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5355\u72ec\u4f7f\u7528\u65f6<span>1.25g<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\/<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b21<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u7b2c<span>1<\/span>\uff5e<span>21<\/span>\u5929\u8fde\u7eed\u670d\u7528\u3002\u4e0e\u5361\u57f9\u4ed6\u6ee8\u8054\u7528\u65f6\uff0c\u62c9\u5e15\u66ff\u5c3c\u7684\u63a8\u8350\u5242\u91cf\u540c\u4e0a\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u6bcf<span>21<\/span>\u5929<span>1<\/span>\u4e2a\u5468\u671f\uff0c\u5efa\u8bae\u5c06\u6bcf\u5929\u5242\u91cf\u4e00\u6b21\u6027\u670d\u7528\uff0c\u4e0d\u63a8\u8350\u5206\u6b21\u670d\u7528\u3002\u5e94\u5728\u9910\u524d\u81f3\u5c11<span>1<\/span>\u5c0f\u65f6\uff0c\u6216\u9910\u540e\u81f3\u5c11<span>1<\/span>\u5c0f\u65f6\u670d\u7528\u3002\u5361\u57f9\u4ed6\u6ee8\u63a8\u8350\u5242\u91cf\u4e3a<span>2g\/<\/span>\uff08<span>m<sup>2<\/sup><\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:;\" \"=\"\">\u25aa<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">d<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff09\uff0c\u5206\u4e24\u6b21\u53e3\u670d\u3002\u95f4\u9694\u7ea6<span>12<\/span>\u5c0f\u65f6\uff0c\u8fde\u670d<span>14<\/span>\u5929\uff0c\u4f11\u606f<span>7<\/span>\u5929\uff0c<span>21<\/span>\u5929\u4e3a\u4e00\u4e2a\u5468\u671f\u3002\u5361\u57f9\u4ed6\u6ee8\u5e94\u548c\u98df\u7269\u540c\u65f6\u670d\u7528\uff0c\u6216\u9910\u540e<span>30<\/span>\u5206\u949f\u5185\u670d\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e3b\u8981\u4e0d\u826f\u53cd\u5e94\u4e3a\u8179\u6cfb\u548c\u76ae\u75b9\uff0c\u8179\u6cfb\u53ef\u5bf9\u75c7\u6b62\u6cfb\uff0c\u7528\u836f\u671f\u95f4\u907f\u514d\u76f4\u63a5\u65e5\u6652\uff0c\u5916\u51fa\u6ce8\u610f\u9632\u6652\u3002\u4f7f\u7528\u672c\u54c1\u53ef\u53d1\u751f\u5fc3\u810f\u6bd2\u6027\uff0c\u4e3b\u8981\u8868\u73b0\u4e3a<span>LVEF<\/span>\u51cf\u4f4e\uff0c\u5efa\u8bae\u6cbb\u7597\u524d\u8bc4\u4f30<span>LVEF<\/span>\uff0c\u6cbb\u7597\u4e2d\u5b9a\u671f\u68c0\u6d4b<span>LVEF<\/span>\uff0c\u82e5<span>LVEF<\/span>\u4e0b\u964d\u81f3\u6b63\u5e38\u503c\u4e0b\u9650\uff0c\u6216\u51fa\u73b0<span>2<\/span>\u7ea7\u6216<span>2<\/span>\u7ea7\u4ee5\u4e0a\u4e0e<span>LVEF<\/span>\u4e0b\u964d\u76f8\u5173\u7684\u75c7\u72b6\uff0c\u5e94\u505c\u836f\u3002\u82e5\u6062\u590d\u81f3\u6b63\u5e38\uff0c\u4e14\u60a3\u8005\u65e0\u75c7\u72b6\uff0c\u53ef\u4ee5\u5728\u505c\u7528\u81f3\u5c11<span>2<\/span>\u5468\u540e\u5c06\u672c\u54c1\u51cf\u91cf\u4f7f\u7528\uff08\u6bcf\u5929<span>1g<\/span>\u4e0e\u5361\u57f9\u4ed6\u6ee8\u8054\u7528\uff09\u3002\u90e8\u5206\u75c5\u4eba\u8fd8\u53ef\u51fa\u73b0\u809d\u529f\u80fd\u635f\u4f24\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u60a3\u8005\u6f0f\u670d\u4e86\u67d0\u4e00\u5929\u7684\u5242\u91cf\uff0c\u7b2c\u4e8c\u5929\u7684\u5242\u91cf\u4e0d\u8981\u52a0\u500d\uff0c\u5728\u4e0b\u4e00\u6b21\u670d\u836f\u65f6\u95f4\u6309\u8ba1\u5212\u7ee7\u7eed\u670d\u7528\u5373\u53ef\u3002\u6cbb\u7597\u5e94\u5f53\u6301\u7eed\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u80fd\u8010\u53d7\u7684\u6bd2\u6027\u53cd\u5e94\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u4e3b\u8981\u7ecf<span>CYP3A4<\/span>\u4ee3\u8c22\u3002\u670d\u836f\u671f\u95f4\u7981\u98df\u8461\u8404\u67da\u3001\u8461\u8404\u67da\u679c\u6c41\uff0c\u4e0e<span>CYP3A4<\/span>\u6291\u5236\u5242\u6216\u8bf1\u5bfc\u5242\u8054\u5408\u7ed9\u836f\u65f6\u9700\u8c28\u614e\uff0c\u8c28\u614e\u4e0e\u8d28\u5b50\u6cf5\u6291\u5236\u5242\u5408\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e5f\u6709\u4e34\u5e8a\u7814\u7a76\u8bc1\u660e\uff0c\u62c9\u5e15\u66ff\u5c3c\u8054\u5408\u5176\u4ed6\u5316\u7597\u836f\u7269\u6216\u5185\u5206\u6ccc\u6cbb\u7597\u836f\u7269\u53ef\u4f7f\u75c5\u4eba\u4e34\u5e8a\u83b7\u76ca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u516d\u3001\u5421\u54af\u66ff\u5c3c<span> Pyrotinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>80mg<\/span>\u3001<span>160mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5421\u54af\u66ff\u5c3c\u8054\u5408\u5361\u57f9\u4ed6\u6ee8\uff0c\u9002\u7528\u4e8e\u6cbb\u7597<span>HER2<\/span>\u9633\u6027\u3001\u65e2\u5f80\u672a\u63a5\u53d7\u6216\u63a5\u53d7\u8fc7\u66f2\u59a5\u73e0\u5355\u6297\u7684\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u3002\u4f7f\u7528\u5421\u54af\u66ff\u5c3c\u524d\u60a3\u8005\u5e94<a name=\"_Hlk44948602\"><\/a>\u63a5\u53d7\u8fc7\u84bd\u73af\u7c7b\u6216\u7d2b\u6749\u7c7b\u5316\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u4f7f\u7528\u5421\u54af\u66ff\u5c3c\u6cbb\u7597\u524d\uff0c\u5e94\u4f7f\u7528\u7ecf\u5145\u5206\u9a8c\u8bc1\u7684\u68c0\u6d4b\u65b9\u6cd5\u8fdb\u884c<span>HER2<\/span>\u72b6\u6001\u7684\u68c0\u6d4b\u3002\u5421\u54af\u66ff\u5c3c\u4ec5\u53ef\u7528\u4e8e<span>HER2<\/span>\u9633\u6027\u7684\u4e73\u817a\u764c\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u7528\u4e8e<span>HER2<\/span>\u9633\u6027\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53ea\u8981\u89c2\u5bdf\u5230\u4e34\u5e8a\u83b7\u76ca\uff0c\u5e94\u7ee7\u7eed\u5421\u54af\u66ff\u5c3c\u6cbb\u7597\uff0c\u76f4\u81f3\u60a3\u8005\u4e0d\u80fd\u8010\u53d7\u6216\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5421\u54af\u66ff\u5c3c\u63a8\u8350\u5242\u91cf\u4e3a<span>400mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u9910\u540e<span>30<\/span>\u5206\u949f\u5185\u53e3\u670d\uff0c\u6bcf\u5929\u540c\u4e00\u65f6\u95f4\u670d\u836f\u3002\u8fde\u7eed\u670d\u7528\uff0c\u6bcf<span>21<\/span>\u5929\u4e3a\u4e00\u4e2a\u5468\u671f\u3002\u5982\u679c\u60a3\u8005\u6f0f\u670d\u67d0\u4e00\u5929\u7684\u5421\u54af\u66ff\u5c3c\uff0c\u4e0d\u9700\u8981\u8865\u670d\uff0c\u4e0b\u4e00\u6b21\u6309\u8ba1\u5212\u670d\u836f\u5373\u53ef\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u5982\u60a3\u8005\u51fa\u73b0\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u901a\u8fc7\u6682\u505c\u7ed9\u836f\u3001\u964d\u4f4e\u5242\u91cf\u6216\u8005\u505c\u6b62\u7ed9\u836f\u8fdb\u884c\u7ba1\u7406\u3002\u5bf9\u4e8e\u8179\u6cfb\u3001\u76ae\u80a4\u4e0d\u826f\u53cd\u5e94\u53ef\u9996\u5148\u8fdb\u884c\u5bf9\u75c7\u6cbb\u7597\u5e76\u5bc6\u5207\u89c2\u5bdf\u3002\u4e00\u4e9b\u6301\u7eed\u5b58\u5728\u7684<span>2<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\u4e5f\u53ef\u80fd\u9700\u8981\u591a\u6b21\u6682\u505c\u7528\u836f\u548c<span>\/<\/span>\u6216\u4e0b\u8c03\u5242\u91cf\u3002\u5982\u6682\u505c\u7ed9\u836f\u540e\u53d7\u8bd5\u8005\u4ecd\u6709\u4e34\u5e8a\u4e0d\u53ef\u63a7\u5236\uff08\u5373\u4e34\u5e8a\u6cbb\u7597\u6216\u89c2\u5bdf\u2264<span>14<\/span>\u5929\u540e\u4ecd\u5b58\u5728\uff0c\u51fa\u73b0\u2265\u4e24\u6b21\uff09\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5219\u5728\u6682\u505c\u540e\u6062\u590d\u7528\u836f\u65f6\u5e94\u51cf\u5c11\u4e00\u4e2a\u6c34\u5e73\u7684\u5242\u91cf\uff0c\u5421\u54af\u66ff\u5c3c\u5141\u8bb8\u4e0b\u8c03\u6700\u4f4e\u5242\u91cf\u4e3a<span>240mg<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u5408\u5e76\u4f7f\u7528<span>CYP3A4<\/span>\u5f3a\u6291\u5236\u5242\u548c\u5f3a\u8bf1\u5bfc\u5242\uff0c\u5e94\u5bc6\u5207\u76d1\u6d4b\uff0c\u7ed3\u5408\u4e34\u5e8a\u89c2\u5bdf\u8003\u8651\u662f\u5426\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5421\u54af\u66ff\u5c3c\u4e3b\u8981\u7ecf\u809d\u810f\u4ee3\u8c22\uff0c\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u7684\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002\u80be\u529f\u80fd\u635f\u4f24\u5bf9\u5421\u54af\u66ff\u5c3c\u66b4\u9732\u5f71\u54cd\u975e\u5e38\u6709\u9650\uff0c\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4ecd\u5e94\u5728\u533b\u5e08\u6307\u5bfc\u4e0b\u8c28\u614e\u4f7f\u7528\u5421\u54af\u66ff\u5c3c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8179\u6cfb\u662f\u5421\u54af\u66ff\u5c3c\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u89c2\u5bdf\u5230\u7684\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u3002\u6cbb\u7597\u671f\u95f4\u60a3\u8005\u5e94\u5173\u6ce8\u6392\u4fbf\u6027\u72b6\u548c\u9891\u7387\u7684\u53d8\u5316\uff0c\u53d1\u73b0\u5927\u4fbf\u4e0d\u6210\u5f62\u540e\uff0c\u5c3d\u65e9\u5f00\u59cb\u6297\u8179\u6cfb\u6cbb\u7597\uff0c\u53ef\u9009\u7528\u6d1b\u54cc\u4e01\u80fa\u6216\u8499\u8131\u77f3\u6563\u3002\u5982\u51fa\u73b0\u6301\u7eed\u7684<span>3<\/span>\u7ea7\u8179\u6cfb\u3001\u6216<span>1<\/span>\uff5e<span>2<\/span>\u7ea7\u8179\u6cfb\u4f34\u5e76\u53d1\u75c7\uff08\u2265<span>2<\/span>\u7ea7\u7684\u6076\u5fc3\u3001\u5455\u5410\u3001\u53d1\u70ed\u3001\u4fbf\u8840\u6216\u8131\u6c34\u7b49\uff09\u65f6\uff0c\u60a3\u8005\u5e94\u7acb\u5373\u8054\u7cfb\u533b\u5e08\u5e76\u63a5\u53d7\u6cbb\u7597\u4e0a\u7684\u6307\u5bfc\uff0c\u5c3d\u65e9\u5f00\u59cb\u5bf9\u75c7\u6cbb\u7597\u3002\u53d1\u751f\u8179\u6cfb\u540e\u53ef\u6839\u636e\u5242\u91cf\u8c03\u6574\u6307\u5bfc\u539f\u5219\u8fdb\u884c\u5904\u7406\u3002\u5bf9\u4e8e\u6cbb\u7597\u671f\u95f4\u9891\u7e41\u53d1\u751f\u8179\u6cfb\u7684\u60a3\u8005\uff0c\u5e94\u8b66\u60d5\u53d1\u751f\u4e25\u91cd\u8179\u6cfb\u7684\u53ef\u80fd\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c1a\u7f3a\u4e4f\u5421\u54af\u66ff\u5c3c\u5728<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u548c\u9752\u5c11\u5e74\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5421\u54af\u66ff\u5c3c\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08<span>PUFFIN<\/span>\uff09\u6570\u636e\u663e\u793a\uff0c\u5421\u54af\u66ff\u5c3c\u8054\u5408\u5361\u57f9\u4ed6\u6ee8\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u5931\u8d25\uff0c\u540c\u65f6\u63a5\u53d7\u8fc7\u84bd\u73af\u7c7b\u6216\u7d2b\u6749\u7c7b\u5316\u7597\u7684<span>HER2<\/span>\u9633\u6027\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\uff0c\u5bf9\u6bd4\u62c9\u5e15\u66ff\u5c3c\u8054\u5408\u5361\u57f9\u4ed6\u6ee8\u53ef\u663e\u8457\u5ef6\u957f\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08<span>12.5<\/span>\u4e2a\u6708<i><span>vs<\/span><\/i><span>6.8<\/span>\u4e2a\u6708\uff0c<span>HR<\/span>\uff1d<span>0.39<\/span>\uff0c<i><span>p<\/span><\/i>\uff1c<span>0.0001<\/span>\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e03\u3001\u5948\u62c9\u66ff\u5c3c<span> Neratinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>40mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u7528\u4e8e<span>HER2<\/span>\u9633\u6027\u7684\u65e9\u671f\u4e73\u817a\u764c\u6210\u5e74\u60a3\u8005\uff0c\u5728\u63a5\u53d7\u542b\u66f2\u59a5\u73e0\u5355\u6297\u8f85\u52a9\u6cbb\u7597\u4e4b\u540e\u7684\u5f3a\u5316\u8f85\u52a9\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8003\u8651\u4f7f\u7528\u672c\u836f\u7684\u60a3\u8005\u9700\u8fdb\u884c<span>HER2<\/span>\u68c0\u6d4b\uff0c<span>HER2<\/span>\u9633\u6027\u60a3\u8005\u65b9\u53ef\u5e94\u7528\u5948\u62c9\u66ff\u5c3c\u8fdb\u884c\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5948\u62c9\u66ff\u5c3c\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>240mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u968f\u9910\u670d\u7528\uff0c\u8fde\u7eed\u7528\u836f\u4e00\u5e74\u3002\u6307\u5bfc\u60a3\u8005\u5728\u6bcf\u5929\u5927\u81f4\u540c\u4e00\u65f6\u95f4\u670d\u7528\u5948\u62c9\u66ff\u5c3c\uff0c\u5e94\u6574\u7247\u541e\u670d\u5948\u62c9\u66ff\u5c3c\uff08\u836f\u7247\u5728\u541e\u670d\u524d\u4e0d\u5f97\u5480\u56bc\u3001\u538b\u788e\u6216\u5288\u5f00\uff09\u3002\u5982\u679c\u60a3\u8005\u6f0f\u670d\uff0c\u4e0d\u5f97\u8865\u670d\u6f0f\u670d\u7684\u5242\u91cf\uff0c\u5e94\u6307\u5bfc\u60a3\u8005\u6309\u6bcf\u5929\u5242\u91cf\u4e8e\u6b21\u65e5\u91cd\u65b0\u670d\u7528\u5948\u62c9\u66ff\u5c3c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e3b\u8981\u4e0d\u826f\u53cd\u5e94\u4e3a\u8179\u6cfb\u3002\u9884\u9632\u6027\u4f7f\u7528\u6b62\u6cfb\u836f\u3001\u996e\u98df\u6539\u53d8\u4ee5\u53ca\u9002\u5f53\u8c03\u6574\u5948\u62c9\u66ff\u5c3c\u5242\u91cf\u53ef\u964d\u4f4e\u8179\u6cfb\u53d1\u751f\u7387\u548c\u8179\u6cfb\u7684\u4e25\u91cd\u7a0b\u5ea6\u3002\u6307\u5bfc\u60a3\u8005\u4e8e\u7b2c\u4e00\u5242\u5948\u62c9\u66ff\u5c3c\u7ed9\u836f\u65f6\u5373\u5f00\u59cb\u9884\u9632\u6027\u670d\u7528\u6b62\u6cfb\u836f\u6d1b\u54cc\u4e01\u80fa\uff0c\u6301\u7eed\u7528\u836f<span>2<\/span>\u4e2a\u5468\u671f\uff08<span>56<\/span>\u5929\uff09\u3002\u6d1b\u54cc\u4e01\u80fa\u7684\u9884\u9632\u6027\u7528\u836f\u65b9\u6848\u5982\u4e0b\u8868\uff1a<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8868<span>7<\/span>&emsp;\u6d1b\u54cc\u4e01\u80fa\u9884\u9632\u6027\u7528\u836f\u65b9\u6848<span><\/span><\/span><\/b>\n<\/p>\n<table class=\"MsoTableGrid\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\" style=\"border-collapse:collapse;border:none;\">\n<tbody>\n<tr>\n<td width=\"539\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5948\u62c9\u66ff\u5c3c\u7528\u836f\u65f6\u95f4<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"577\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6d1b\u54cc\u4e01\u80fa\u5242\u91cf\u548c\u670d\u836f\u9891\u7387<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"539\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7b2c<span>1<\/span>\uff5e<span>2<\/span>\u5468\uff08\u7b2c<span>1<\/span>\uff5e<span>14<\/span>\u5929\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"577\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4mg<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u6bcf\u5929\u4e09\u6b21<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"539\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7b2c<span>3<\/span>\uff5e<span>4<\/span>\u5468\uff08\u7b2c<span>15<\/span>\uff5e<span>28<\/span>\u5929\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"577\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4mg<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u6bcf\u5929\u4e24\u6b21<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"539\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7b2c<span>5<\/span>\uff5e<span>8<\/span>\u5468\uff08\u7b2c<span>29<\/span>\uff5e<span>56<\/span>\u5929\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"577\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4mg<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u6bcf\u5929\u4e24\u6b21<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"539\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7b2c<span>9<\/span>\uff5e<span>52<\/span>\u5468\uff08\u7b2c<span>57<\/span>\uff5e<span>365<\/span>\u5929\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"577\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4mg<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6309\u9700\u4f7f\u7528\uff0c\u4e0d\u5f97\u8d85\u8fc7<span>16mg\/d<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e34\u5e8a\u9700\u8981\uff0c\u53ef\u4ee5\u901a\u8fc7\u6682\u65f6\u4e2d\u65ad\u5948\u62c9\u66ff\u5c3c\u7ed9\u836f\u6216\u51cf\u5c11\u5176\u7528\u836f\u5242\u91cf\u6765\u63a7\u5236\u8179\u6cfb\uff0c\u6700\u4f4e\u5948\u62c9\u66ff\u5c3c\u670d\u7528\u5242\u91cf\u4e3a<span>120mg\/d<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u5948\u62c9\u66ff\u5c3c\u8d77\u59cb\u5242\u91cf\u964d\u4f4e\u81f3<span>80mg<\/span>\u3002\u5bf9\u4e8e\u8f7b\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u4e0d\u63a8\u8350\u5242\u91cf\u8c03\u6574\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u836f\u7269\u76f8\u4e92\u4f5c\u7528\uff1a\uff08<span>1<\/span>\uff09\u8d28\u5b50\u6cf5\u6291\u5236\u5242\uff08<span>PPI<\/span>\uff09\uff1a\u907f\u514d\u4e0e\u5948\u62c9\u66ff\u5c3c\u8054\u5408\u7528\u836f\u3002\uff08<span>2<\/span>\uff09<span>H<sub>2<\/sub><\/span>\u53d7\u4f53\u62ee\u6297\u5242\uff1a\u5728\u4e0b\u4e00\u5242<span>H<sub>2<\/sub><\/span>\u53d7\u4f53\u62ee\u6297\u5242\u7ed9\u836f\u524d\u81f3\u5c11<span>2<\/span>\u5c0f\u65f6\u6216\u5728<span>H<sub>2<\/sub><\/span>\u53d7\u4f53\u62ee\u6297\u5242\u7ed9\u836f\u540e<span>10<\/span>\u5c0f\u65f6\u670d\u7528\u5948\u62c9\u66ff\u5c3c\u3002\uff08<span>3<\/span>\uff09\u6297\u9178\u836f\uff1a\u5728\u6297\u9178\u836f\u7ed9\u836f<span>3<\/span>\u5c0f\u65f6\u540e\u65b9\u53ef\u7ed9\u4e88\u5948\u62c9\u66ff\u5c3c\u3002\uff08<span>4<\/span>\uff09\u907f\u514d\u5948\u62c9\u66ff\u5c3c\u4e0e\u5f3a\u6548\u6216\u4e2d\u7b49<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u4f34\u968f\u7528\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u4e34\u5e8a\u7814\u7a76\u8868\u660e\uff0c\u5948\u62c9\u66ff\u5c3c\u8054\u5408\u5361\u57f9\u4ed6\u6ee8\u5bf9\u6cbb\u7597\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u53ef\u4f7f\u75c5\u4eba\u4e34\u5e8a\u83b7\u76ca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u516b\u3001\u54cc\u67cf\u897f\u5229<span> Palbociclib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>75mg<\/span>\u3001<span>100mg<\/span>\u3001<span>125mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u9002\u7528\u4e8e\u6fc0\u7d20\u53d7\u4f53\uff08<span>HR<\/span>\uff09\u9633\u6027\u3001<span>HER2<\/span>\u9634\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff1a\uff08<span>1<\/span>\uff09\u4e0e\u82b3\u9999\u5316\u9176\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\uff0c\u4f5c\u4e3a\u7edd\u7ecf\u540e\u5973\u6027\u60a3\u8005\u7684\u521d\u59cb\u5185\u5206\u6ccc\u6cbb\u7597\u3002\u9274\u4e8e\u82b3\u9999\u5316\u9176\u6291\u5236\u5242\u7684\u4f5c\u7528\u673a\u5236\uff0c\u7edd\u7ecf\u524d<span>\/<\/span>\u56f4\u7edd\u7ecf\u671f\u5973\u6027\u63a5\u53d7\u54cc\u67cf\u897f\u5229\u4e0e\u82b3\u9999\u5316\u9176\u6291\u5236\u5242\u8054\u5408\u6cbb\u7597\u65f6\uff0c\u5fc5\u987b\u8fdb\u884c\u5375\u5de2\u5207\u9664\u6216\u4f7f\u7528\u4fc3\u9ec4\u4f53\u751f\u6210\u6fc0\u7d20\u91ca\u653e\u6fc0\u7d20\u6fc0\u52a8\u5242\u6291\u5236\u5375\u5de2\u529f\u80fd\u3002\uff08<span>2<\/span>\uff09\u4e0e\u6c1f\u7ef4\u53f8\u7fa4\u8054\u5408\u4f7f\u7528\u6cbb\u7597\u5185\u5206\u6ccc\u6cbb\u7597\u540e\u8fdb\u5c55\u7684\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u5973\u6027\u60a3\u8005\u3002\u54cc\u67cf\u897f\u5229\u8054\u5408\u6c1f\u7ef4\u53f8\u7fa4\u7528\u4e8e\u7edd\u7ecf\u524d<span>\/<\/span>\u56f4\u7edd\u7ecf\u671f\u5973\u6027\uff0c\u9700\u8981\u4e0e\u4fc3\u9ec4\u4f53\u751f\u6210\u6fc0\u7d20\u91ca\u653e\u6fc0\u7d20\u6fc0\u52a8\u5242\u8054\u5408\u7528\u836f\u3002\uff08<span>3<\/span>\uff09\u7537\u6027\u4e73\u817a\u764c\uff1a<span>2019<\/span>\u5e74<span>4<\/span>\u6708<span>4<\/span>\u65e5\uff0c<span>FDA<\/span>\u6279\u51c6\u4e86\u7f8e\u56fd\u54cc\u67cf\u897f\u5229<span>HR<\/span>\u9633\u6027\u3001<span>HER2<\/span>\u9634\u6027\u665a\u671f\u7537\u6027\u4e73\u817a\u764c\u7684\u9002\u5e94\u8bc1\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5728\u63a5\u53d7\u54cc\u67cf\u897f\u5229\u6cbb\u7597\u524d\uff0c\u5e94\u5728\u6709\u8d44\u8d28\u7684\u75c5\u7406\u5b9e\u9a8c\u5ba4\u8fdb\u884c\u68c0\u6d4b\u8bc1\u5b9e<span>HR<\/span>\u9633\u6027\u3001<span>HER2<\/span>\u9634\u6027\u60a3\u8005\u65b9\u53ef\u4f7f\u7528\u3002<span>HR<\/span>\u9633\u6027\u7684\u5b9a\u4e49\u4e3a\u96cc\u6fc0\u7d20\u53d7\u4f53\u514d\u75ab\u7ec4\u5316\u67d3\u8272\u663e\u793a\u8d85\u8fc7<span>1%<\/span>\u7684\u80bf\u7624\u7ec6\u80de\u6838\u67d3\u8272\u9633\u6027\u3002<span>HER2<\/span>\u9634\u6027\u7684\u5b9a\u4e49\u4e3a<span>IHC0-1+<\/span>\u6216<span>FISH<\/span>\u9634\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u8d77\u59cb\u5242\u91cf\u662f<span>125mg\/d<\/span>\uff0c<span>4<\/span>\u5468\u4e3a\u4e00\u4e2a\u7528\u836f\u5468\u671f\uff1a\u670d\u836f<span>3<\/span>\u5468\u540e\u9700\u505c\u836f<span>1<\/span>\u5468\u3002\u5e94\u4e0e\u98df\u7269\u540c\u670d\uff0c\u4e0d\u5f97\u4e0e\u8461\u8404\u67da\u6216\u8461\u8404\u67da\u6c41\u540c\u670d\uff0c\u6700\u597d\u968f\u9910\u670d\u836f\u4ee5\u786e\u4fdd\u54cc\u67cf\u897f\u5229\u66b4\u9732\u91cf\u4e00\u81f4\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5e38\u89c1\u526f\u4f5c\u7528\u4e3a\u9aa8\u9ad3\u6291\u5236\uff0c\u56e0\u6b64\u5efa\u8bae\u5728\u4f7f\u7528\u672c\u54c1\u524d\u884c\u8840\u5e38\u89c4\u68c0\u67e5\uff0c\u5728\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u8ba1\u6570\u2265<span>1<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u4e14\u8840\u5c0f\u677f\u8ba1\u6570\u2265<span>50<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u65f6\u5f00\u59cb\u63a5\u53d7\u6cbb\u7597\u3002\u5728\u7b2c<span>15<\/span>\u5929\u68c0\u6d4b\u8840\u5e38\u89c4\uff0c\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u8ba1\u6570<span>0.5<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u81f3\u2264<span>1<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u65f6\uff0c\u53ef\u4ee5\u7ee7\u7eed\u670d\u836f\u81f3<span>21<\/span>\u5929\u3002\u5982\u679c\u7b2c<span>15<\/span>\u5929\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u8ba1\u6570\u2264<span>0.5<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u65f6\uff0c\u9700\u6682\u505c\u670d\u7528\u54cc\u67cf\u897f\u5229\uff0c\u76f4\u81f3\u6062\u590d\u81f3\u2265<span>1<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff0c\u518d\u4ee5\u964d\u4f4e\u4e00\u4e2a\u5242\u91cf\u7ea7\u5f00\u59cb\u4e0b\u4e00\u7597\u7a0b\u6cbb\u7597\u3002\u5982\u679c\u4e0b\u4e2a\u7597\u7a0b\u524d\u4e00\u5929\u68c0\u6d4b\u8840\u5e38\u89c4\uff0c\u4e2d\u6027\u7c92\u7ec6\u80de\u6062\u590d\u81f3\u2265<span>1<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff0c\u53ef\u4ee5\u539f\u5242\u91cf\u5f00\u59cb\u4e0b\u4e00\u7597\u7a0b\uff0c\u4f46\u5982\u679c\u5ef6\u8fdf\u6062\u590d\uff0c\u5219\u9700\u8981\u964d\u4f4e\u4e00\u4e2a\u5242\u91cf\u7ea7\u5f00\u59cb\u4e0b\u4e00\u7597\u7a0b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u907f\u514d\u4f34\u968f\u4f7f\u7528<span>CYP3A<\/span>\u5f3a\u6548\u6291\u5236\u5242\uff0c\u8003\u8651\u5f3a\u6548\u6291\u5236\u5242\u66ff\u6362\u4e3a\u6ca1\u6709\u6216\u53ea\u5fae\u5f31<span>CYP3A<\/span>\u6291\u5236\u4f5c\u7528\u7684\u5176\u4ed6\u4f34\u968f\u7528\u836f\u3002\u5982\u679c\u60a3\u8005\u5fc5\u987b\u4f34\u968f\u7528\u836f<span>CYP3A<\/span>\u5f3a\u6548\u6291\u5236\u5242\uff0c\u5219\u5c06\u54cc\u67cf\u897f\u5229\u5242\u91cf\u51cf\u5c11\u81f3<span>75mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u3002\u5982\u679c\u505c\u7528\u5f3a\u6548\u6291\u5236\u5242\uff0c\u5219\u5c06\u54cc\u67cf\u897f\u5229\u7684\u5242\u91cf\u589e\u52a0\u81f3\u5f00\u59cb\u4f7f\u7528<span>CYP3A<\/span>\u5f3a\u6548\u6291\u5236\u5242\u4e4b\u524d\u7684\u5242\u91cf\uff08\u5728\u6291\u5236\u5242\u7684<span>3<\/span>\uff5e<span>5<\/span>\u4e2a\u534a\u8870\u671f\u540e\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e5d\u3001\u963f\u8d1d\u897f\u5229 <span>Abemaciclib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>50mg<\/span>\u3001<span>100mg<\/span>\u3001<span>150mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">HR<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9633\u6027\u3001<span>HER2<\/span>\u9634\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff1a\uff08<span>1<\/span>\uff09\u4e0e\u82b3\u9999\u5316\u9176\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\u4f5c\u4e3a\u7edd\u7ecf\u540e\u5973\u6027\u60a3\u8005\u7684\u521d\u59cb\u5185\u5206\u6ccc\u6cbb\u7597\u3002\uff08<span>2<\/span>\uff09\u4e0e\u6c1f\u7ef4\u53f8\u7fa4\u8054\u5408\u7528\u4e8e\u65e2\u5f80\u66fe\u63a5\u53d7\u5185\u5206\u6ccc\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5728\u63a5\u53d7\u963f\u8d1d\u897f\u5229\u6cbb\u7597\u524d\uff0c\u5e94\u5728\u6709\u8d44\u8d28\u7684\u75c5\u7406\u5b9e\u9a8c\u5ba4\u8fdb\u884c\u68c0\u6d4b\u8bc1\u5b9e<span>HR<\/span>\u9633\u6027\u3001<span>HER2<\/span>\u9634\u6027\u60a3\u8005\u65b9\u53ef\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u8d1d\u897f\u5229\u6cbb\u7597\u5e94\u8be5\u7531\u5177\u6709\u6297\u80bf\u7624\u6cbb\u7597\u7ecf\u9a8c\u7684\u533b\u5e08\u8d77\u59cb\u4f7f\u7528\u5e76\u8fdb\u884c\u6cbb\u7597\u671f\u95f4\u7684\u76d1\u6d4b\u3002\u963f\u8d1d\u897f\u5229\u4e0e\u5185\u5206\u6ccc\u6cbb\u7597\u8054\u5408\u4f7f\u7528\u65f6\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>150mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\u3002\u5982\u679c\u60a3\u8005\u5455\u5410\u6216\u6f0f\u670d\u67d0\u4e00\u6b21\u963f\u8d1d\u897f\u5229\uff0c\u4e0d\u5e94\u8865\u670d\uff0c\u4e0b\u4e00\u6b21\u670d\u836f\u65f6\u95f4\u6309\u8ba1\u5212\u670d\u836f\u5373\u53ef\u3002\u963f\u8d1d\u897f\u5229\u53ef\u5728\u7a7a\u8179\u6216\u8fdb\u98df\u60c5\u51b5\u4e0b\u7ed9\u836f\u3002\u963f\u8d1d\u897f\u5229\u4e0d\u5e94\u968f\u8461\u8404\u67da\u6216\u8461\u8404\u67da\u6c41\u540c\u670d\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u5ea6\uff08<span>Child<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">&#8211;<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">Pugh A<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\uff09\u6216\u4e2d\u5ea6\uff08<span>Child<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">&#8211;<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">Pugh B<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\uff09\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u987b\u8c03\u6574\u5242\u91cf\uff1b\u91cd\u5ea6\uff08<span>Child<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">&#8211;<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">Pugh C<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\uff09\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5efa\u8bae\u964d\u4f4e\u7ed9\u836f\u9891\u7387\u81f3\u6bcf\u5929<span>1<\/span>\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u5728\u4ee5\u4e0b\u65f6\u95f4\u76d1\u6d4b\u5168\u8840\u7ec6\u80de\u8ba1\u6570\uff0c\u5305\u62ec\uff1a\u5f00\u59cb\u963f\u8d1d\u897f\u5229\u6cbb\u7597\u4e4b\u524d\u3001\u6cbb\u7597\u6700\u521d<span>2<\/span>\u4e2a\u6708\u5185\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\u3001\u63a5\u4e0b\u6765<span>2<\/span>\u4e2a\u6708\u5185\u6bcf\u6708\u4e00\u6b21\u4ee5\u53ca\u51fa\u73b0\u4e34\u5e8a\u6307\u5f81\u65f6\u3002\u5728\u5f00\u59cb\u6cbb\u7597\u524d\uff0c\u5efa\u8bae\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u8ba1\u6570\u5e94<span>\u22651.5<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u3001\u8840\u5c0f\u677f\u8ba1\u6570\u5e94<span>\u2265100<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u4e14\u8840\u7ea2\u86cb\u767d\u5e94<span>\u226580g\/L<\/span>\u3002\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u7ecf\u5e38\u88ab\u62a5\u544a\uff0c\u6cbb\u7597\u5f00\u59cb\u81f3<span>3<\/span>\u7ea7\u6216<span>4<\/span>\u7ea7\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u53d1\u751f\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a<span>29<\/span>\uff5e<span>33<\/span>\u5929\uff0c\u81f3\u7f13\u89e3\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a<span>11<\/span>\uff5e<span>15<\/span>\u5929\u3002\u5bf9\u4e8e\u53d1\u751f<span>3<\/span>\u7ea7\u6216<span>4<\/span>\u7ea7\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u7684\u60a3\u8005\uff0c\u5efa\u8bae\u6682\u505c\u7ed9\u836f\uff0c\u76f4\u81f3\u6bd2\u6027\u964d\u4f4e\u81f3<span>2<\/span>\u7ea7\u6216\u4ee5\u4e0b\u3002\u91cd\u65b0\u7ed9\u836f\u65f6\u8003\u8651\u662f\u5426\u9700\u8981\u964d\u4f4e\u5242\u91cf\u3002<\/span><u><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/u>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5e38\u89c1\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u8179\u6cfb\uff0c\u53d1\u751f\u7387\u5728\u6cbb\u7597\u7684\u7b2c<span>1<\/span>\u4e2a\u6708\u5185\u6700\u9ad8\uff0c\u968f\u540e\u964d\u4f4e\u3002\u5728\u5404\u9879\u7814\u7a76\u4e2d\uff0c\u6cbb\u7597\u5f00\u59cb\u81f3\u9996\u6b21\u8179\u6cfb\u4e8b\u4ef6\u53d1\u751f\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a<span>6<\/span>\uff5e<span>8<\/span>\u5929\uff0c\u8179\u6cfb\u6301\u7eed\u4e2d\u4f4d\u65f6\u95f4\u4e3a<span>9<\/span>\uff5e<span>12<\/span>\u5929\uff08<span>2<\/span>\u7ea7\uff09\u548c<span>6<\/span>\uff5e<span>8<\/span>\u5929\uff08<span>3<\/span>\u7ea7\uff09\u3002\u901a\u8fc7\u652f\u6301\u6cbb\u7597\uff08\u4f8b\u5982\u6d1b\u54cc\u4e01\u80fa\uff09\u548c<span>\/<\/span>\u6216\u8c03\u6574\u5242\u91cf\uff0c\u8179\u6cfb\u53ef\u7f13\u89e3\u81f3\u57fa\u7ebf\u6216\u8f83\u4f4e\u7ea7\u522b\u3002\u5982\u679c\u53d1\u751f\u8179\u6cfb\uff0c\u5e94\u5f53\u5c3d\u65e9\u91c7\u53d6\u652f\u6301\u6027\u63aa\u65bd\u3002\u8fd9\u4e9b\u63aa\u65bd\u5305\u62ec\u4ee5\u4e0b\uff1a\u5728\u9996\u6b21\u51fa\u73b0\u7a00\u4fbf\u75c7\u72b6\u65f6\uff0c\u60a3\u8005\u5e94\u5f53\u5f00\u59cb\u6297\u8179\u6cfb\u6cbb\u7597\u3002\u9f13\u52b1\u60a3\u8005\u996e\u7528\u6db2\u4f53\uff08\u4f8b\u5982\uff0c\u6bcf\u5929<span>8<\/span>\uff5e<span>10<\/span>\u676f\u767d\u5f00\u6c34\uff09\u3002\u5982\u679c\u63a5\u53d7\u6297\u8179\u6cfb\u6cbb\u7597\u540e\uff0c\u8179\u6cfb\u672a\u80fd\u5728<span>24<\/span>\u5c0f\u65f6\u5185\u7f13\u89e3\u81f3\u81f3\u5c11<span>1<\/span>\u7ea7\uff0c\u5219\u5e94\u5f53\u6682\u505c\u836f\u7269\uff0c\u76f4\u81f3\u8179\u6cfb\u7f13\u89e3\u81f3\u81f3\u5c11<span>1<\/span>\u7ea7\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5e94\u907f\u514d\u5408\u5e76\u4f7f\u7528\u5f3a\u6548<span>CYP3A4<\/span>\u6291\u5236\u5242\u3002\u5982\u679c\u4e0d\u80fd\u907f\u514d\u4f7f\u7528\u5f3a\u6548<span>CYP3A4<\/span>\u6291\u5236\u5242\uff0c\u963f\u8d1d\u897f\u5229\u7684\u5242\u91cf\u5e94\u964d\u4f4e\u81f3<span>100mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\u3002\u5982\u679c\u7ec8\u6b62<span>CYP3A4<\/span>\u6291\u5236\u5242\u6cbb\u7597\uff0c\u963f\u8d1d\u897f\u5229\u5242\u91cf\u5e94\u5347\u9ad8\u81f3\u5f00\u59cb<span>CYP3A4<\/span>\u6291\u5236\u5242\u6cbb\u7597\u524d\u6240\u4f7f\u7528\u7684\u5242\u91cf\uff08\u5728\u8be5<span>CYP3A4<\/span>\u6291\u5236\u5242\u7684<span>3<\/span>\uff5e<span>5<\/span>\u4e2a\u534a\u8870\u671f\u4e4b\u540e\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u3001\u897f\u8fbe\u672c\u80fa<span> Chidamide<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>5mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8054\u5408\u82b3\u9999\u5316\u9176\u6291\u5236\u5242\u7528\u4e8e<span>HR<\/span>\u9633\u6027\u3001<span>HER2<\/span>\u9634\u6027\u3001\u7edd\u7ecf\u540e\u3001\u7ecf\u5185\u5206\u6ccc\u6cbb\u7597\u590d\u53d1\u6216\u8fdb\u5c55\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u63a5\u53d7\u897f\u8fbe\u672c\u80fa\u6cbb\u7597\u524d\uff0c\u7ecf\u75c5\u7406\u5b66\u8bc1\u5b9e<span>HR<\/span>\u9633\u6027\u3001<span>HER2<\/span>\u9634\u6027\u60a3\u8005\u65b9\u53ef\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u8d77\u59cb\u5242\u91cf\u662f\u6bcf\u6b21\u670d\u836f<span>30mg<\/span>\uff0c\u6bcf\u5468\u670d\u836f\u4e24\u6b21\uff0c\u4e24\u6b21\u670d\u836f\u95f4\u9694\u4e0d\u5e94\u5c11\u4e8e<span>3<\/span>\u5929\uff08\u5982\u5468\u4e00\u548c\u5468\u56db\u3001\u5468\u4e8c\u548c\u5468\u4e94\u3001\u5468\u4e09\u548c\u5468\u516d\u7b49\uff09\u3002\u6bcf<span>4<\/span>\u5468\u4e3a\u4e00\u4e2a\u7528\u836f\u5468\u671f\u3002\u82e5\u75c5\u60c5\u672a\u8fdb\u5c55\u6216\u672a\u51fa\u73b0\u4e0d\u80fd\u8010\u53d7\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5efa\u8bae\u6301\u7eed\u670d\u836f\u3002\u9910\u540e<span>30<\/span>\u5206\u949f\u670d\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u4e3b\u8981\u662f\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94\uff0c\u56e0\u6b64\u5efa\u8bae\u5728\u4f7f\u7528\u672c\u54c1\u524d\u884c\u8840\u5e38\u89c4\u68c0\u67e5\uff0c\u6307\u6807\u6ee1\u8db3\u4ee5\u4e0b\u6761\u4ef6\u65b9\u53ef\u5f00\u59cb\u7528\u836f\uff1a\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u503c\u2265<span>1.5<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff0c\u8840\u5c0f\u677f\u2265<span>75<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff0c\u8840\u7ea2\u86cb\u767d\u2265<span>90g\/L<\/span>\u3002\u7528\u836f\u671f\u95f4\u9700\u5b9a\u671f\u68c0\u6d4b\u8840\u5e38\u89c4\uff08\u901a\u5e38\u4e3a\u6bcf\u5468\u4e00\u6b21\uff09\u3002\u5f53\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94\u4e25\u91cd\u7a0b\u5ea6\u8fbe\u5230<span>3<\/span>\u7ea7\u6216<span>4<\/span>\u7ea7\u65f6\uff0c\u5e94\u6682\u505c\u672c\u54c1\u7528\u836f\u3002\u5f85\u6307\u6807\u6062\u590d\u81f3\u670d\u836f\u524d\u6c34\u5e73\u65f6\uff0c\u7ecf\u8fc7\u8fde\u7eed\u4e24\u6b21\u68c0\u67e5\u786e\u8ba4\uff0c\u53ef\u7ee7\u7eed\u672c\u54c1\u6cbb\u7597\u3002\u6062\u590d\u7528\u836f\u65f6\u7684\u5242\u91cf\u5982\u4e0b\uff1a\u5982\u4e4b\u524d\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a<span>3<\/span>\u7ea7\uff0c\u6062\u590d\u7528\u836f\u65f6\u53ef\u91c7\u7528\u539f\u5242\u91cf\u6216\u5242\u91cf\u964d\u4f4e\u81f3<span>20mg\/<\/span>\u6b21\uff1b\u5982\u4e4b\u524d\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a<span>4<\/span>\u7ea7\uff0c\u6062\u590d\u7528\u836f\u65f6\u5242\u91cf\u5e94\u964d\u4f4e\u81f3<span>20mg\/<\/span>\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u4e34\u5e8a\u76f8\u5173\u6d53\u5ea6\u4e0b\uff0c\u897f\u8fbe\u672c\u80fa\u5bf9\u4eba\u809d\u5fae\u7c92\u4f53<span>CYP450<\/span>\u9176\u4e3b\u8981\u4e9a\u578b\u65e0\u660e\u663e\u6291\u5236\u6216\u8bf1\u5bfc\u4f5c\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\"><br \/>\n<\/span> <\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ae\u80a4\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u4e00\u3001\u4f0a\u9a6c\u66ff\u5c3c<span> Imatinib<\/span><\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08<span>1<\/span>\uff09\u7247\u5242\uff1a<span>100mg<\/span>\u3001<span>400mg<\/span>\uff1b\uff08<span>2<\/span>\uff09\u80f6\u56ca\uff1a<span>50mg<\/span>\u3001<span>100mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5bf9\u4e0d\u80fd\u5207\u9664\u548c<span>\/<\/span>\u6216\u8f6c\u79fb\u6027<span>KIT<\/span>\u7a81\u53d8\u7684\u6076\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u7ecf\u7531\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u786e\u5b9a\u80bf\u7624\u4e3a<span>C-KIT<\/span>\u7a81\u53d8\u9633\u6027\uff0c\u624d\u53ef\u4f7f\u7528\u4f0a\u9a6c\u66ff\u5c3c\u6cbb\u7597\uff0c\u514d\u75ab\u7ec4\u5316<span>CD117<\/span>\u9633\u6027\u4e0d\u80fd\u66ff\u4ee3<span>KIT<\/span>\u7a81\u53d8\u57fa\u56e0\u68c0\u6d4b\uff0c\u4f0a\u9a6c\u66ff\u5c3c\u4e0d\u80fd\u7528\u4e8e<span>KIT<\/span>\u91ce\u751f\u578b\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e<span>KIT<\/span>\u7a81\u53d8\u7684\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>400mg<\/span>\uff1b<span>400mg<\/span>\u6cbb\u7597\u8fdb\u5c55\u540e\u53ef\u9075\u533b\u5631\u589e\u91cf\u81f3<span>600mg<\/span>\u3001<span>800mg<\/span>\uff0c\u4ecd\u6709\u90e8\u5206\u60a3\u8005\u83b7\u76ca\uff0c\u4f46\u4e0d\u826f\u53cd\u5e94\u4ea6\u52a0\u91cd\u3002<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5e38\u89c1\u7684\u53cd\u5e94\u5305\u62ec\u6c34\u80bf\u3001\u4e4f\u529b\u3001\u98df\u6b32\u51cf\u9000\u3001\u76ae\u75b9\u3001\u7c92\u7ec6\u80de\u4e0b\u964d\u7b49\uff0c\u670d\u836f\u671f\u95f4\u5e94\u5b9a\u671f\u68c0\u6d4b\u8840\u5e38\u89c4\u3001\u809d\u80be\u529f\u80fd\u3002<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u662f<span>CYP3A4<\/span>\u7684\u5e95\u7269\uff0c\u540c\u65f6\u7ed9\u4e88<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u540e\u4f0a\u9a6c\u66ff\u5c3c\u7684\u8840\u6d46\u6d53\u5ea6\u964d\u4f4e\uff0c\u4ece\u800c\u5bfc\u81f4\u7597\u6548\u51cf\u4f4e\uff0c\u5e94\u907f\u514d\u4f0a\u9a6c\u66ff\u5c3c\u4e0e<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u540c\u65f6\u670d\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u4f0a\u9a6c\u66ff\u5c3c\u5e94\u5728\u8fdb\u9910\u65f6\u670d\u7528\uff0c\u5e76\u996e\u4e00\u5927\u676f\u6c34\u3002\u5e76\u6ce8\u610f\uff1a\uff08<span>1<\/span>\uff09\u4f7f\u7528\u80f6\u56ca\u5242\u578b\u65f6\uff0c\u5bf9\u4e8e\u4e0d\u80fd\u541e\u54bd\u80f6\u56ca\u7684\u60a3\u8005\uff08\u5305\u62ec\u513f\u7ae5\uff09\uff0c\u53ef\u4ee5\u5c06\u80f6\u56ca\u5185\u836f\u7269\u5206\u6563\u4e8e\u6c34\u6216\u82f9\u679c\u6c41\u4e2d\u3002\u4f7f\u7528\u7247\u5242\u65f6\uff0c\u53ef\u4ee5\u5c06\u836f\u7247\u5206\u6563\u4e8e\u4e0d\u542b\u6c14\u4f53\u7684\u6c34\u6216\u82f9\u679c\u6c41\u4e2d\uff08<span>100mg<\/span>\u7247\u7ea6\u7528<span>50ml<\/span>\uff0c<span>400mg<\/span>\u7ea6\u7528<span>200ml<\/span>\uff09\u3002\u5e94\u6405\u62cc\u6df7\u60ac\u6db2\uff0c\u4e00\u65e6\u836f\u7247\u5d29\u89e3\u5b8c\u5168\u5e94\u7acb\u5373\u670d\u7528\u3002\uff08<span>2<\/span>\uff09\u5982\u679c\u63a5\u53d7\u4f0a\u9a6c\u66ff\u5c3c\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u51fa\u73b0\u4e25\u91cd\u975e\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94\uff08\u5982\u4e25\u91cd\u4f53\u6db2\u6f74\u7559\uff09\uff0c\u5e94\u505c\u836f\uff0c\u76f4\u5230\u4e0d\u826f\u53cd\u5e94\u6d88\u5931\uff0c\u7136\u540e\u518d\u6839\u636e\u8be5\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\u8c03\u6574\u5242\u91cf\u3002\uff08<span>3<\/span>\uff09\u5bf9\u4e8e<span>3<\/span>\u5c81\u4ee5\u4e0a\u513f\u7ae5\u4f7f\u7528\u4f0a\u9a6c\u66ff\u5c3c\u7684\u7814\u7a76\uff0c\u4e3b\u8981\u6765\u81ea\u56fd\u5916\u513f\u7ae5\u7814\u7a76\u6570\u636e\uff0c\u4e2d\u56fd\u513f\u7ae5\u4eba\u7fa4\u7528\u836f\u5b89\u5168\u6709\u6548\u6027\u6570\u636e\u6709\u9650\u3002\u5c1a\u65e0<span>3<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u7528\u836f\u7ecf\u9a8c\u3002\uff08<span>4<\/span>\uff09\u5df2\u6709\u62a5\u544a\u663e\u793a\u63a5\u53d7\u4f0a\u9a6c\u66ff\u5c3c\u7684\u513f\u7ae5\u548c\u9752\u6625\u524d\u671f\u9752\u5c11\u5e74\u51fa\u73b0\u53d1\u80b2\u8fdf\u7f13\u3002\u6682\u4e0d\u77e5\u4f0a\u9a6c\u66ff\u5c3c\u5ef6\u957f\u6cbb\u7597\u5bf9\u513f\u7ae5\u53d1\u80b2\u7684\u957f\u671f\u5f71\u54cd\u3002\u56e0\u6b64\uff0c\u5efa\u8bae\u5bf9\u4f7f\u7528\u4f0a\u9a6c\u66ff\u5c3c\u7684\u513f\u7ae5\u7684\u53d1\u80b2\u60c5\u51b5\u8fdb\u884c\u5bc6\u5207\u76d1\u6d4b\u3002<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u4e8c\u3001<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u7ef4\u83ab\u975e\u5c3c<span> Vemurafenib<\/span><\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c<\/span><\/b><b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">240mg<\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u786e\u5b9a\u7684<span>BRAF V600<\/span>\u7a81\u53d8\u9633\u6027\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u7ecf\u7531\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u786e\u5b9a\u80bf\u7624\u4e3a<span>BRAF V600<\/span>\u7a81\u53d8\u9633\u6027\uff0c\u624d\u53ef\u4f7f\u7528\u7ef4\u83ab\u975e\u5c3c\u6cbb\u7597\uff0c\u7ef4\u83ab\u975e\u5c3c\u4e0d\u80fd\u7528\u4e8e<span>BRAF<\/span>\u91ce\u751f\u578b\u9ed1\u8272\u7d20\u7624\u60a3\u8005<i>\u3002<\/i><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:26.85pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ef4\u83ab\u975e\u5c3c\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>960mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\uff08<span>1920mg<\/span>\u6bcf\u5929\u603b\u5242\u91cf\uff09\uff0c\u4e0d\u63a8\u8350\u5c06\u5242\u91cf\u51cf\u81f3\u4f4e\u4e8e<span>480mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:26.85pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u76ae\u80a4\u53cd\u5e94\u5982\u76ae\u75b9\uff0c\u5149\u654f\u53cd\u5e94\u7b49<i>\u3002<\/i><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u7ebf<span>QTc<\/span>\uff1e<span>500ms<\/span>\u65f6\u4e0d\u5efa\u8bae\u5f00\u59cb\u670d\u7528\u7ef4\u83ab\u975e\u5c3c\uff0c\u5bf9\u4e8e\u5b58\u5728\u65e0\u6cd5\u7ea0\u6b63\u7684\u7535\u89e3\u8d28\u5f02\u5e38\u3001\u957f<span>QTc<\/span>\u7efc\u5408\u5f81\u6216\u6b63\u5728\u670d\u7528\u5df2\u77e5\u80fd\u5ef6\u957f<span>QTc<\/span>\u95f4\u671f\u7684\u836f\u7269\u7684\u60a3\u8005\uff0c\u4e0d\u5efa\u8bae\u63a5\u53d7\u7ef4\u83ab\u975e\u5c3c\u6cbb\u7597<i>\u3002<\/i><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ca1\u6709\u8bc1\u636e\u8868\u660e\u7ef4\u83ab\u975e\u5c3c\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\u53ef\u4ee5\u589e\u6548\uff0c\u4f7f\u7528\u7ef4\u83ab\u975e\u5c3c\u65f6\u4e0d\u5efa\u8bae\u4e0e\u4f0a\u5339\u6728\u5355\u6297\u8054\u5408\u7528\u836f<i>\u3002<\/i><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u598a\u5a20\u671f\u5987\u5973\u7981\u6b62\u4f7f\u7528\u7ef4\u83ab\u975e\u5c3c\uff0c\u9664\u975e\u5bf9\u4e8e\u6bcd\u4eb2\u7684\u53ef\u80fd\u53d7\u76ca\u8d85\u8fc7\u5bf9\u80ce\u513f\u7684\u53ef\u80fd\u98ce\u9669\u3002\u4e0d\u5efa\u8bae\u54fa\u4e73\u671f\u5987\u5973\u4f7f\u7528\u7ef4\u83ab\u975e\u5c3c\uff0c\u5fc5\u987b\u5728\u6743\u8861\u54fa\u4e73\u5582\u517b\u5bf9\u5a74\u513f\u7684\u76ca\u5904\u4ee5\u53ca\u6cbb\u7597\u5bf9\u6bcd\u4eb2\u7684\u76ca\u5904\u4e4b\u540e\uff0c\u505a\u51fa\u662f\u5426\u505c\u6b62\u6bcd\u4e73\u5582\u517b\u6216\u505c\u6b62\u7ef4\u83ab\u975e\u5c3c\u6cbb\u7597\u7684\u51b3\u5b9a<i>\u3002<\/i><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f7f\u7528\u7ef4\u83ab\u975e\u5c3c\u65f6\u4e0d\u5efa\u8bae\u4e0e\u7ecf<span>CYP1A2<\/span>\u548c<span>CYP3A4<\/span>\u4ee3\u8c22\u3001\u4e14\u5b89\u5168\u6cbb\u7597\u7a97\u8f83\u7a84\u7684\u836f\u7269\u8054\u5408\u5e94\u7528\uff0c\u4f7f\u7528\u7ef4\u83ab\u975e\u5c3c\u65f6\u614e\u7528\u5f3a\u6548<span>CYP3A4<\/span>\u6291\u5236\u5242\u6216\u8bf1\u5bfc\u5242\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e09\u3001\u8fbe\u62c9\u975e\u5c3c<span> Dabrafenib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>50mg<\/span>\u3001<span>75mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fbe\u62c9\u975e\u5c3c\u8054\u5408\u66f2\u7f8e\u66ff\u5c3c\u9002\u7528\u4e8e\u6cbb\u7597<span>BRAF V600<\/span>\u7a81\u53d8\u9633\u6027\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fbe\u62c9\u975e\u5c3c\u8054\u5408\u66f2\u7f8e\u66ff\u5c3c\u9002\u7528\u4e8e<span>BRAF V600<\/span>\u7a81\u53d8\u9633\u6027\u7684\u2162\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u5b8c\u5168\u5207\u9664\u540e\u7684\u8f85\u52a9\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u8054\u5408\u66f2\u7f8e\u66ff\u5c3c\u6cbb\u7597\u524d\u987b\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u8fdb\u884c<span>BRAF V600<\/span>\u7a81\u53d8\u68c0\u6d4b\uff0c\u786e\u8ba4\u4e3a<span>BRAF V600<\/span>\u7a81\u53d8\u9633\u6027\u7684\u60a3\u8005\u65b9\u53ef\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u3002\u672c\u54c1\u8054\u5408\u66f2\u7f8e\u66ff\u5c3c\u4e0d\u9002\u7528\u4e8e<span>BRAF<\/span>\u91ce\u751f\u578b\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fbe\u62c9\u975e\u5c3c\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>150mg<\/span>\u6bcf\u5929\u4e24\u6b21\uff08<span>300mg<\/span>\u6bcf\u5929\u603b\u5242\u91cf\uff09\u3002\u672c\u54c1\u9700\u8054\u5408\u66f2\u7f8e\u66ff\u5c3c\u6cbb\u7597\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fbe\u62c9\u975e\u5c3c\u5e94\u5728\u9910\u524d\u81f3\u5c11<span>1<\/span>\u5c0f\u65f6\u524d\u6216\u9910\u540e\u81f3\u5c11<span>2<\/span>\u5c0f\u65f6\u540e\u670d\u7528\uff0c\u7ed9\u836f\u95f4\u9694\u7ea6<span>12<\/span>\u5c0f\u65f6\u3002\u5e94\u5728\u6bcf\u5929\u76f8\u540c\u65f6\u95f4\u670d\u7528\u672c\u54c1\uff0c\u5982\u679c\u9519\u8fc7\u4e00\u5242\u8fbe\u62c9\u975e\u5c3c\uff0c\u4e14\u8ddd\u4e0b\u4e00\u6b21\u670d\u836f\u65f6\u95f4\u4e0d\u8db3<span>6<\/span>\u5c0f\u65f6\uff0c\u5219\u4e0d\u5e94\u8865\u670d\u3002\u5f53\u8fbe\u62c9\u975e\u5c3c\u8054\u5408\u5e94\u7528\u66f2\u7f8e\u66ff\u5c3c\u65f6\uff0c\u5e94\u5728\u6bcf\u5929\u76f8\u540c\u65f6\u95f4\u670d\u7528\u66f2\u7f8e\u66ff\u5c3c\u6bcf\u5929\u4e00\u6b21\uff0c\u4e0e\u5728\u65e9\u6668\u6216\u665a\u4e0a\u7ed9\u836f\u7684\u8fbe\u62c9\u975e\u5c3c\u4e00\u8d77\u670d\u7528\u3002\u8bf7\u52ff\u6253\u5f00\u3001\u538b\u788e\u6216\u63b0\u65ad\u8fbe\u62c9\u975e\u5c3c\u80f6\u56ca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u7ed9\u4e88\u8fbe\u62c9\u975e\u5c3c\u8054\u5408\u5e94\u7528\u66f2\u7f8e\u66ff\u5c3c\u6cbb\u7597\u65f6\uff0c\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\uff1a\u53d1\u70ed\u3001\u5bd2\u6218\u3001\u76ae\u75b9\u3001\u5934\u75db\u3001\u5934\u6655\u3001\u5173\u8282\u75db\u3001\u54b3\u55fd\u7b49\u3002\u5982\u679c\u51fa\u73b0\u6cbb\u7597\u76f8\u5173\u7684\u6bd2\u6027\uff0c\u5219\u4e24\u79cd\u6cbb\u7597\u5e94\u540c\u65f6\u8fdb\u884c\u5242\u91cf\u51cf\u5c11\u3001\u4e2d\u65ad\u6216\u505c\u6b62\u3002\u5982\u679c\u51fa\u73b0\u4e0e\u8fbe\u62c9\u975e\u5c3c\u76f8\u5173\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u8461\u8404\u819c\u708e\u3001\u975e\u76ae\u80a4\u6076\u6027\u80bf\u7624\uff09\uff0c\u4ec5\u9700\u5bf9\u8fbe\u62c9\u975e\u5c3c\u6cbb\u7597\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u3001\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u9996\u6b21\u6cbb\u7597\u65f6\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u5e94\u614e\u7528\u8fbe\u62c9\u975e\u5c3c\u3002\u8001\u5e74\u60a3\u8005\uff08\u2265<span>65<\/span>\u5c81\uff09\u65e0\u9700\u8c03\u6574\u521d\u59cb\u5242\u91cf\u3002\u5c1a\u672a\u786e\u5b9a\u8fbe\u62c9\u975e\u5c3c\u5728\u513f\u7ae5\u548c\u9752\u5c11\u5e74\uff08\uff1c<span>18<\/span>\u5c81\uff09\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.CYP2C8<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6216<span>CYP3A4<\/span>\u5f3a\u6548\u6291\u5236\u5242\u6216\u8bf1\u5bfc\u5242\u7684\u836f\u7269\u53ef\u80fd\u5f71\u54cd\u8fbe\u62c9\u975e\u5c3c\u7684\u8840\u836f\u6d53\u5ea6\u3002\u53ef\u80fd\u60c5\u51b5\u4e0b\uff0c\u63a5\u53d7\u8fbe\u62c9\u975e\u5c3c\u6cbb\u7597\u65f6\u5e94\u8003\u8651\u66ff\u4ee3\u73b0\u6709\u670d\u7528\u836f\u7269\u4e2d<span>CYP2C8<\/span>\u548c<span>CYP3A4<\/span>\u7684\u6291\u5236\u5242\u6216\u8bf1\u5bfc\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u7f8e\u56fd\u548c\u6b27\u76df\uff0c\u8fbe\u62c9\u975e\u5c3c\u8054\u5408\u66f2\u7f8e\u66ff\u5c3c\u5206\u522b\u83b7\u6279\u7528\u4e8e<span>BRAF V600E<\/span>\u548c<span>BRAF V600<\/span>\u7a81\u53d8\u7684\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u6cbb\u7597\u3002\u5728\u7f8e\u56fd\uff0c\u8fbe\u62c9\u975e\u5c3c\u8054\u5408\u66f2\u7f8e\u66ff\u5c3c\u83b7\u6279\u7528\u4e8e<span>BRAF V600E<\/span>\u7a81\u53d8\u7684\u5c40\u665a\u671f\u6216\u8f6c\u79fb\u6027\u7532\u72b6\u817a\u672a\u5206\u5316\u764c\u6cbb\u7597\u3002\u76ee\u524d\u8fd9\u4e24\u4e2a\u9002\u5e94\u8bc1\u5728\u4e2d\u56fd\u5c1a\u672a\u83b7\u6279\uff0c\u53ef\u5728\u4e0e\u60a3\u8005\u5145\u5206\u6c9f\u901a\u7684\u60c5\u51b5\u4e0b\u4f7f\u7528\u3002\u5728\u7f8e\u56fd\uff0c\u63a8\u8350\u5242\u91cf\u4e3a\u8fbe\u62c9\u975e\u5c3c<span>150mg<\/span>\u6bcf\u5929\u4e24\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56db\u3001\u66f2\u7f8e\u66ff\u5c3c<span> Trametinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>0.5mg<\/span>\u3001<span>2mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66f2\u7f8e\u66ff\u5c3c\u8054\u5408\u8fbe\u62c9\u975e\u5c3c\u9002\u7528\u4e8e\u6cbb\u7597<span>BRAF V600<\/span>\u7a81\u53d8\u9633\u6027\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66f2\u7f8e\u66ff\u5c3c\u8054\u5408\u8fbe\u62c9\u975e\u5c3c\u9002\u7528\u4e8e<span>BRAF V600<\/span>\u7a81\u53d8\u9633\u6027\u7684\u2162\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u5b8c\u5168\u5207\u9664\u540e\u7684\u8f85\u52a9\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66f2\u7f8e\u66ff\u5c3c\u8054\u5408\u8fbe\u62c9\u975e\u5c3c\u6cbb\u7597\u524d\u987b\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u8fdb\u884c<span>BRAF V600<\/span>\u7a81\u53d8\u68c0\u6d4b\uff0c\u786e\u8ba4\u4e3a<span>BRAF V600<\/span>\u7a81\u53d8\u9633\u6027\u7684\u60a3\u8005\u65b9\u53ef\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u3002\u672c\u54c1\u8054\u5408\u8fbe\u62c9\u975e\u5c3c\u4e0d\u9002\u7528\u4e8e<span>BRAF<\/span>\u91ce\u751f\u578b\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66f2\u7f8e\u66ff\u5c3c\u7684\u63a8\u8350\u5242\u91cf\u662f<span>2mg<\/span>\u6bcf\u5929\u4e00\u6b21\u53e3\u670d\uff0c\u9700\u8054\u5408\u8fbe\u62c9\u975e\u5c3c\u6cbb\u7597\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u53cd\u5e94\u3002\u9996\u6b21\u5242\u91cf\u51cf\u5c11\uff0c\u6bcf\u5929\u4e00\u6b21<span>1.5mg<\/span>\uff1b\u7b2c\u4e8c\u6b21\u51cf\u91cf\uff0c\u6bcf\u5929\u4e00\u6b21<span>1mg<\/span>\uff1b\u5982\u679c\u4e0d\u80fd\u8010\u53d7\u6bcf\u5929\u4e00\u6b21<span>1mg<\/span>\uff0c\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66f2\u7f8e\u66ff\u5c3c\u5e94\u5728\u9910\u524d\u81f3\u5c11<span>1<\/span>\u5c0f\u65f6\u524d\u6216\u9910\u540e\u81f3\u5c11<span>2<\/span>\u5c0f\u65f6\u540e\u670d\u7528\u3002\u5e94\u5728\u6bcf\u5929\u76f8\u540c\u65f6\u95f4\u670d\u7528\u66f2\u7f8e\u66ff\u5c3c\u3002\u5982\u679c\u9519\u8fc7\u4e00\u5242\u672c\u54c1\uff0c\u987b\u6700\u665a\u5728\u9884\u5b9a\u7684\u4e0b\u4e00\u6b21\u7ed9\u836f\u4e4b\u524d<span>12<\/span>\u5c0f\u65f6\u8865\u4e0a\u3002\u5982\u679c\u8ddd\u79bb\u4e0b\u6b21\u9884\u5b9a\u7684\u7ed9\u836f\u65f6\u95f4\u77ed\u4e8e<span>12<\/span>\u5c0f\u65f6\uff0c\u5219\u4e0d\u5e94\u8be5\u8865\u670d\u3002\u672c\u54c1\u8054\u5408\u8fbe\u62c9\u975e\u5c3c\u65f6\uff0c\u5e94\u5728\u6bcf\u5929\u76f8\u540c\u65f6\u95f4\u670d\u7528\u672c\u54c1\u6bcf\u5929\u4e00\u6b21\uff0c\u4e0e\u5728\u65e9\u6668\u6216\u665a\u4e0a\u7ed9\u836f\u7684\u8fbe\u62c9\u975e\u5c3c\u4e00\u8d77\u670d\u7528\u3002\u4e0d\u5e94\u5480\u56bc\u6216\u538b\u788e\u672c\u54c1\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u7ed9\u4e88\u66f2\u7f8e\u66ff\u5c3c\u8054\u5408\u5e94\u7528\u8fbe\u62c9\u975e\u5c3c\u6cbb\u7597\u65f6\uff0c\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\uff1a\u53d1\u70ed\u3001\u5bd2\u6218\u3001\u76ae\u75b9\u3001\u5934\u75db\u3001\u5934\u6655\u3001\u5173\u8282\u75db\u3001\u54b3\u55fd\u7b49\u3002\u5982\u679c\u51fa\u73b0\u6cbb\u7597\u76f8\u5173\u7684\u6bd2\u6027\uff0c\u5219\u4e24\u79cd\u6cbb\u7597\u5e94\u540c\u65f6\u8fdb\u884c\u5242\u91cf\u51cf\u5c11\u3001\u4e2d\u65ad\u6216\u505c\u6b62\u3002\u5bf9\u4e8e\u4e3b\u8981\u4e0e\u66f2\u7f8e\u66ff\u5c3c\u76f8\u5173\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u89c6\u7f51\u819c\u9759\u8109\u963b\u585e\u3001\u89c6\u7f51\u819c\u8272\u7d20\u4e0a\u76ae\u8131\u79bb\u3001\u95f4\u8d28\u6027\u80ba\u708e\u548c\u5355\u7eaf\u6027\u9759\u8109\u8840\u6813\u6813\u585e\uff09\uff0c\u4ec5\u9700\u5bf9\u66f2\u7f8e\u66ff\u5c3c\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u3001\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u3001\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u5e94\u614e\u7528\u8fbe\u62c9\u975e\u5c3c\u3002\u8001\u5e74\u60a3\u8005\uff08\u2265<span>65<\/span>\u5c81\uff09\u65e0\u9700\u8c03\u6574\u521d\u59cb\u5242\u91cf\u3002\u5c1a\u672a\u786e\u5b9a\u8fbe\u62c9\u975e\u5c3c\u5728\u513f\u7ae5\u548c\u9752\u5c11\u5e74\uff08\uff1c<span>18<\/span>\u5c81\uff09\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ecf\u6c34\u89e3\u9176\u4ee3\u8c22\u7684\u836f\u7269\u53ef\u80fd\u5f71\u54cd\u66f2\u7f8e\u66ff\u5c3c\u66b4\u9732\uff0c\u836f\u7269\u95f4\u76f8\u4e92\u4f5c\u7528\u4e0d\u80fd\u6392\u9664\u3002\u66f2\u7f8e\u66ff\u5c3c\u5e94\u8c28\u614e\u5408\u7528\u5f3a\u6548<span>P-<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u7f8e\u56fd\u548c\u6b27\u76df\uff0c\u66f2\u7f8e\u66ff\u5c3c\u8054\u5408\u8fbe\u62c9\u975e\u5c3c\u5206\u522b\u83b7\u6279\u7528\u4e8e<span>BRAF V600E<\/span>\u548c<span>BRAF V600<\/span>\u7a81\u53d8\u7684\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u6cbb\u7597\u3002\u5728\u7f8e\u56fd\uff0c\u66f2\u7f8e\u66ff\u5c3c\u8054\u5408\u8fbe\u62c9\u975e\u5c3c\u83b7\u6279\u7528\u4e8e<span>BRAF V600E<\/span>\u7a81\u53d8\u7684\u5c40\u665a\u671f\u6216\u8f6c\u79fb\u6027\u7532\u72b6\u817a\u672a\u5206\u5316\u764c\u6cbb\u7597\u3002\u76ee\u524d\u8fd9\u4e24\u4e2a\u9002\u5e94\u8bc1\u5728\u4e2d\u56fd\u5c1a\u672a\u83b7\u6279\uff0c\u53ef\u5728\u4e0e\u60a3\u8005\u5145\u5206\u6c9f\u901a\u7684\u60c5\u51b5\u4e0b\u4f7f\u7528\u3002\u5728\u7f8e\u56fd\uff0c\u63a8\u8350\u5242\u91cf\u4e3a\u66f2\u7f8e\u66ff\u5c3c<span>2mg<\/span>\u6bcf\u5929\u4e00\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e94\u3001\u5e15\u535a\u5229\u73e0\u5355\u6297<span> Pembrolizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>4ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u76ae\u80a4\u578b\u9ed1\u8272\u7d20\u7624\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7ecf\u4e00\u7ebf\u6cbb\u7597\u5931\u8d25\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u63a8\u8350\u7ed9\u836f\u65b9\u6848\u4e3a<span>200mg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\u6216\u8005<span>400mg<\/span>\u6bcf<span>6<\/span>\u5468\u4e00\u6b21\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u4f46\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u505c\u836f\uff0c\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e3b\u8981\u4e0d\u826f\u53cd\u5e94\u662f\u75b2\u52b3\u3001\u7619\u75d2\u3001\u8179\u6cfb\u548c\u76ae\u75b9\u3002\u63a5\u53d7\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u53ef\u53d1\u751f\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u4e25\u91cd\u548c\u81f4\u6b7b\u75c5\u4f8b\u3002\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u53ef\u540c\u65f6\u53d1\u751f\u5728\u591a\u4e2a\u5668\u5b98\u7cfb\u7edf\uff0c\u9700\u8981\u5bf9\u4e8e\u7591\u4f3c\u75c5\u4f8b\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u5b9a\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u5e94\u6682\u65f6\u505c\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\uff0c\u5e76\u5e94\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u3002\u5f53\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u6539\u5584\u81f3\u2264<span>1<\/span>\u7ea7\u65f6\uff0c\u9700\u81f3\u5c11\u4e00\u4e2a\u6708\u7684\u65f6\u95f4\u9010\u6b65\u51cf\u5c11\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7684\u7528\u91cf\u76f4\u81f3\u505c\u836f\u3002\u5018\u82e5\u53d1\u751f\u7cd6\u76ae\u8d28\u6fc0\u7d20\u65e0\u6cd5\u63a7\u5236\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u65f6\uff0c\u53ef\u4ee5\u8003\u8651\u4f7f\u7528\u5176\u4ed6\u5168\u8eab\u6027\u514d\u75ab\u6291\u5236\u5242\u3002\u5982\u679c\u4e0d\u826f\u53cd\u5e94\u4fdd\u6301\u5728\u2264<span>1<\/span>\u7ea7\uff0c\u4e14\u7cd6\u76ae\u8d28\u6fc0\u7d20\u5242\u91cf\u5df2\u964d\u81f3\u2264<span>10mg<\/span>\u6cfc\u5c3c\u677e\u6216\u7b49\u6548\u5242\u91cf\uff0c\u53ef\u5728\u6700\u540e\u4e00\u6b21\u4f7f\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ed9\u836f\u540e<span>12<\/span>\u5468\u5185\u91cd\u65b0\u5f00\u59cb\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u3002\u5bf9\u4e8e\u4efb\u4f55\u590d\u53d1\u6027<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u4ee5\u53ca\u4efb\u4f55<span>4<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u6c38\u4e45\u505c\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u51fa\u73b0\u8f7b\u4e2d\u5ea6\u8f93\u6db2\u53cd\u5e94\u7684\u60a3\u8005\u5728\u5bc6\u5207\u76d1\u6d4b\u4e0b\u53ef\u7ee7\u7eed\u63a5\u53d7\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\uff0c\u53ef\u8003\u8651\u7528\u89e3\u70ed\u9547\u75db\u7c7b\u6297\u708e\u836f\u548c\u6297\u7ec4\u80fa\u836f\u9884\u9632\u3002\u5bf9\u4e8e\u91cd\u5ea6\u7684\u8f93\u6db2\u53cd\u5e94\uff0c\u5fc5\u987b\u505c\u6b62\u8f93\u6db2\u5e76\u6c38\u4e45\u505c\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5b55\u5987\u5728\u598a\u5a20\u671f\u4f7f\u7528\u53ef\u80fd\u4f1a\u5bf9\u80ce\u513f\u9020\u6210\u4f24\u5bb3\uff0c\u9664\u975e\u5b55\u5987\u7684\u4e34\u5e8a\u75be\u75c5\u9700\u8981\uff0c\u598a\u5a20\u671f\u4e0d\u5f97\u7528\u836f\u3002\u5efa\u8bae\u80b2\u9f84\u5973\u6027\u5728\u7528\u836f\u671f\u95f4\u91c7\u7528\u9ad8\u6548\u907f\u5b55\u65b9\u6cd5\uff0c\u5e76\u5728\u6700\u540e\u4e00\u6b21\u7528\u836f\u540e\u56db\u4e2a\u6708\u5185\u6301\u7eed\u907f\u5b55\u3002\u4e0d\u80fd\u6392\u9664\u672c\u54c1\u5bf9\u65b0\u751f\u513f\u7684\u98ce\u9669\uff0c\u5e94\u6743\u8861\u54fa\u4e73\u5bf9\u80ce\u513f\u7684\u83b7\u76ca\u4ee5\u53ca\u672c\u54c1\u6cbb\u7597\u5bf9\u5973\u6027\u60a3\u8005\u7684\u83b7\u76ca\u6765\u51b3\u7b56\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5c1a\u672a\u786e\u5b9a<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u4f7f\u7528\u672c\u54c1\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u5728\u8001\u5e74\u4eba\u7fa4\u4e2d\u4e0d\u9700\u8981\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u5c1a\u672a\u5728\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u8fdb\u884c\u672c\u54c1\u7684\u76f8\u5173\u7814\u7a76\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5728\u4f7f\u7528\u8be5\u836f\u524d\u907f\u514d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u516d\u3001\u7279\u745e\u666e\u5229\u5355\u6297<span> Toripalimab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">80mg<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\uff08<span>2ml<\/span>\uff09<span>\/<\/span>\u74f6\u3001<span>240mg<\/span>\uff08<span>6ml<\/span>\uff09<span>\/<\/span>\u74f6<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u5168\u8eab\u7cfb\u7edf\u6cbb\u7597\u5931\u8d25\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u9ed1\u8272\u7d20\u7624\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>3mg\/kg<\/span>\uff0c\u9759\u8109\u8f93\u6ce8\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff0c\u76f4\u5230\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u5df2\u89c2\u5bdf\u5230\u90e8\u5206\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u7684\u60a3\u8005\u5b58\u5728\u80bf\u7624\u975e\u5178\u578b\u53cd\u5e94\uff0c\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u5728\u5f71\u50cf\u5b66\u4e0a\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u665a\u671f\u9ecf\u819c\u578b\u9ed1\u8272\u7d20\u7624\uff0c<span>PD-1<\/span>\u5355\u6297\u5355\u836f\u7597\u6548\u6709\u9650\uff0c\u6839\u636e<span>CT13<\/span>\u7814\u7a76\uff0c\u5efa\u8bae\u91c7\u7528\u7279\u745e\u666e\u5229\u5355\u6297\uff08<span>3mg\/kg<\/span>\uff0c\u9759\u8109\u8f93\u6ce8\u6bcf\u4e24\u5468\u4e00\u6b21\uff09\u8054\u5408\u963f\u6614\u66ff\u5c3c\uff08<span>5mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\uff09\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e0d\u826f\u53cd\u5e94\u4e3a\u8d2b\u8840\u3001<span>ALT<\/span>\u5347\u9ad8\u3001\u4e4f\u529b\u3001<span>AST<\/span>\u5347\u9ad8\u3001\u76ae\u75b9\u3001\u53d1\u70ed\u3001\u8840\u4fc3\u7532\u72b6\u817a\u6fc0\u7d20\u5347\u9ad8\u3001\u767d\u7ec6\u80de\u8ba1\u6570\u51cf\u5c11\u3001\u54b3\u55fd\u3001\u7619\u75d2\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u75c7\u3001\u98df\u6b32\u4e0b\u964d\u3001\u8840\u7cd6\u5347\u9ad8\u548c\u8840\u80c6\u7ea2\u7d20\u5347\u9ad8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u5927\u591a\u6570\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u662f\u53ef\u9006\u7684\uff0c\u4e14\u53ef\u901a\u8fc7\u4e2d\u65ad\u7279\u745e\u666e\u5229\u5355\u6297\u5e76\u4f7f\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u652f\u6301\u6cbb\u7597\u3002\u5bf9\u4e8e\u5927\u90e8\u5206<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u53ca\u67d0\u4e9b\u7279\u5b9a\u7684<span>2<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u9700\u6682\u505c\u7ed9\u836f\uff0c\u5e76\u7ed9\u4e88<span>1<\/span>\uff5e<span>2mg\/<\/span>\uff08<span>kg<\/span><\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u2022<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">d<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\uff09\u5f3a\u7684\u677e\u7b49\u6548\u5242\u91cf\u53ca\u5176\u4ed6\u6cbb\u7597\uff0c\u76f4\u81f3\u6539\u5584\u5230\u2264<span>1<\/span>\u7ea7\u3002\u7cd6\u76ae\u8d28\u6fc0\u7d20\u9700\u81f3\u5c11\u4e00\u4e2a\u6708\u7684\u65f6\u95f4\u9010\u6e10\u51cf\u91cf\u76f4\u81f3\u505c\u836f\uff0c\u5feb\u901f\u51cf\u91cf\u53ef\u80fd\u5f15\u8d77\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u7684\u53cd\u590d\u3002\u5982\u679c\u4e0d\u826f\u53cd\u5e94\u5728\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u540e\u7ee7\u7eed\u6076\u5316\u6216\u65e0\u6539\u5584\uff0c\u5219\u5e94\u589e\u52a0\u7cd6\u76ae\u8d28\u6fc0\u7d20\u4ee5\u5916\u7684\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e<span>4<\/span>\u7ea7\u53ca\u67d0\u4e9b\u7279\u5b9a\u7684<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ca\u4efb\u4f55\u590d\u53d1\u6027<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u672b\u6b21\u7ed9\u836f\u540e<span>12<\/span>\u5468\u5185<span>2<\/span>\uff5e<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u672a\u6539\u5584\u5230<span>0<\/span>\uff5e<span>1<\/span>\u7ea7\uff08\u9664\u5916\u5185\u5206\u6ccc\u75be\u75c5\uff09\uff0c\u4ee5\u53ca\u672b\u6b21\u7ed9\u836f<span>12<\/span>\u5468\u5185\u7cd6\u76ae\u8d28\u6fc0\u7d20\u672a\u80fd\u964d\u81f3\u2264<span>10mg\/d<\/span>\u5f3a\u7684\u677e\u7b49\u6548\u5242\u91cf\uff0c\u5e94\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u7981\u5fcc\uff1a\uff08<span>1<\/span>\uff09\u7981\u6b62\u7528\u4e8e\u5bf9\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\u6d3b\u6027\u6210\u5206\u6216\u8f85\u6599\u5b58\u5728\u8d85\u654f\u53cd\u5e94\u7684\u60a3\u8005\u3002\uff08<span>2<\/span>\uff09\u4e0d\u53ef\u4e0e\u5176\u4ed6\u836f\u54c1\u6df7\u5408\u6216\u7a00\u91ca\uff0c\u836f\u74f6\u4e2d\u5269\u4f59\u7684\u836f\u7269\u4e0d\u53ef\u91cd\u590d\u4f7f\u7528\u3002\uff08<span>3<\/span>\uff09\u4e0d\u5f97\u91c7\u7528\u9759\u8109\u63a8\u6ce8\u6216\u5355\u6b21\u5feb\u901f\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56e0\u53ef\u80fd\u5e72\u6270\u672c\u54c1\u836f\u6548\u5b66\u6d3b\u6027\uff0c\u5e94\u907f\u514d\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002\u4f46\u662f\u5982\u679c\u4e3a\u4e86\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u540e\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p><b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><br \/>\n<\/span><\/b> <\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9aa8\u4e0e\u8f6f\u7ec4\u7ec7\u80bf\u7624\u7528\u836f<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e00\u3001\u4f9d\u7ef4\u83ab\u53f8<span> Everolimus<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.5mg<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u3001<span>5mg<\/span>\u3001<span>10mg<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9700\u8981\u6cbb\u7597\u5e72\u9884\u4f46\u4e0d\u9002\u4e8e\u624b\u672f\u5207\u9664\u7684\u7ed3\u8282\u6027\u786c\u5316\u75c7\u76f8\u5173\u7684\u5ba4\u7ba1\u819c\u4e0b\u5de8\u7ec6\u80de\u661f\u5f62\u7ec6\u80de\u7624\u6210\u4eba\u548c\u513f\u7ae5\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u6cbb\u7597\u4e0d\u9700\u7acb\u5373\u624b\u672f\u6cbb\u7597\u7684\u7ed3\u8282\u6027\u786c\u5316\u75c7\u76f8\u5173\u7684\u80be\u8840\u7ba1\u5e73\u6ed1\u808c\u8102\u80aa\u7624\u6210\u4eba\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u63a8\u8350\u5242\u91cf\u4e3a<span>10mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u53e3\u670d\u7ed9\u836f\uff0c\u5728\u6bcf\u4e00\u5929\u540c\u4e00\u65f6\u95f4\u670d\u7528\uff0c\u53ef\u4e0e\u98df\u7269\u540c\u670d\u6216\u4e0d\u4e0e\u98df\u7269\u540c\u65f6\u670d\u7528\uff0c\u4e0d\u5e94\u5480\u56bc\u548c\u538b\u788e\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9057\u6f0f\u5242\u91cf\uff1a\u672c\u54c1\u5728\u6b63\u5e38\u670d\u7528\u65f6\u95f4\u540e<span>6<\/span>\u5c0f\u65f6\u5185\u5747\u53ef\u8865\u670d\u9057\u6f0f\u5242\u91cf\uff0c\u8d85\u8fc7<span>6<\/span>\u5c0f\u65f6\u540e\u5e94\u8df3\u8fc7\u8be5\u5242\u91cf\uff0c\u6b21\u65e5\u6309\u6b63\u5e38\u65f6\u95f4\u670d\u7528\u672c\u54c1\u3002\u4e0d\u53ef\u5c06\u5242\u91cf\u7ffb\u500d\u4ee5\u5f25\u8865\u9057\u6f0f\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u809d\u529f\u80fd\u635f\u4f24\u4f1a\u4f7f\u4f9d\u7ef4\u83ab\u53f8\u66b4\u9732\u91cf\u589e\u52a0\uff0c\u6309\u5982\u4e0b\u65b9\u5f0f\u8fdb\u884c\u7ed9\u836f\u8c03\u6574\uff1a\uff08<span>1<\/span>\uff09\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\uff1a\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u5929<span>7.5mg<\/span>\uff1b\u5982\u679c\u4e0d\u80fd\u5f88\u597d\u5730\u8010\u53d7\uff0c\u53ef\u5c06\u5242\u91cf\u964d\u81f3\u6bcf\u5929<span>5mg<\/span>\u3002\uff08<span>2<\/span>\uff09\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\uff1a\u63a8\u8350\u5242\u91cf\u662f\u6bcf\u5929<span>5mg<\/span>\uff1b\u5982\u679c\u4e0d\u80fd\u5f88\u597d\u5730\u8010\u53d7\uff0c\u53ef\u5c06\u5242\u91cf\u964d\u81f3\u6bcf\u5929<span>2.5mg<\/span>\u3002\uff08<span>3<\/span>\uff09\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\uff1a\u5982\u679c\u9884\u671f\u7684\u83b7\u76ca\u9ad8\u4e8e\u98ce\u9669\uff0c\u53ef\u4ee5\u91c7\u7528\u6bcf\u5929<span>2.5mg<\/span>\uff0c\u4f46\u4e0d\u5f97\u8d85\u8fc7\u8fd9\u4e00\u5242\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u53e3\u8154\u708e\u7b49\uff1b\u5e94\u7279\u522b\u6ce8\u610f\u95f4\u8d28\u6027\u80ba\u708e\u7684\u53d1\u751f\uff0c\u53ef\u80fd\u4f1a\u53d1\u751f\u808c\u9150\u3001\u8840\u7cd6\u548c\u8840\u8102\u5f02\u5e38\uff0c\u6ce8\u610f\u7528\u836f\u671f\u95f4\u590d\u67e5\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u5408\u5e76\u4f7f\u7528\u5f3a\u6548<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\uff0c\u786e\u9700\u5408\u7528\u7684\uff0c\u9700\u589e\u52a0\u5242\u91cf\uff0c\u6700\u5927\u5242\u91cf\u6bcf\u5929<span>20mg<\/span>\u3002\u5982\u9700\u4f7f\u7528<span>CYP3A4<\/span>\u4e2d\u5ea6\u6291\u5236\u5242\u6216<span>P-<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\uff0c\u51cf\u91cf\u81f3\u6bcf\u5929<span>2.5mg<\/span>\uff0c\u5982\u679c\u8010\u53d7\u53ef\u589e\u52a0\u81f3\u5242\u91cf\u6bcf\u5929<span>5mg<\/span>\u3002\u907f\u514d\u5408\u7528\u53ef\u6291\u5236<span>CYP<\/span>\u548c<span>P-<\/span>\u7cd6\u86cb\u767d\u6d3b\u6027\u7684\u98df\u7269\u6216\u8425\u517b\u8865\u5145\u5242\uff0c\u5982\u8461\u8404\u67da\u6c41\u7b49\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u5e94\u907f\u514d\u63a5\u79cd\u6d3b\u75ab\u82d7\uff0c\u907f\u514d\u4e0e\u63a5\u79cd\u8fc7\u6d3b\u75ab\u82d7\u7684\u4eba\u5bc6\u5207\u63a5\u89e6\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u598a\u5a20\u5987\u5973\u670d\u7528\u65f6\u53ef\u80fd\u5bf9\u80ce\u513f\u4ea7\u751f\u5371\u5bb3\uff0c\u5e94\u5145\u5206\u544a\u77e5\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u3001<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5730\u8212\u5355\u6297<span> Denosumab<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>120mg<\/span>\uff08<span>1.7ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u4e0d\u53ef\u624b\u672f\u5207\u9664\u6216\u8005\u624b\u672f\u5207\u9664\u53ef\u80fd\u5bfc\u81f4\u4e25\u91cd\u529f\u80fd\u969c\u788d\u7684\u9aa8\u5de8\u7ec6\u80de\u7624\uff0c\u5305\u62ec\u6210\u4eba\u548c\u9aa8\u9abc\u53d1\u80b2\u6210\u719f\uff08\u5b9a\u4e49\u4e3a\u81f3\u5c11\u4e00\u5904\u6210\u719f\u957f\u9aa8\u4e14\u4f53\u91cd\u2265<span>45kg<\/span>\uff09\u7684\u9752\u5c11\u5e74\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5730\u8212\u5355\u6297\u6cbb\u7597<span>120mg<\/span>\u6bcf<span>4<\/span>\u5468\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\uff08\u4e0a\u81c2\u3001\u5927\u817f\u6216\u8179\u90e8\uff09\uff0c\u7981\u6b62\u9759\u8109\u3001\u808c\u8089\u548c\u76ae\u5185\u6ce8\u5c04\uff0c\u6cbb\u7597\u7b2c<span>1<\/span>\u4e2a\u6708\u7684\u7b2c<span>8<\/span>\u548c\u7b2c<span>15<\/span>\u5929\u9700\u5730\u8212\u5355\u6297<span>120mg<\/span>\u76ae\u4e0b\u8865\u5145\u6ce8\u5c04\u5404\u4e00\u6b21\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5730\u8212\u5355\u6297\u6cbb\u7597\u524d\u5fc5\u987b\u5148\u68c0\u6d4b\u8840\u9499\u6c34\u5e73\uff0c\u5982\u6709\u4f4e\u9499\u8840\u75c7\u9700\u8981\u5148\u7ea0\u6b63\u3002\u5bf9\u4e8e\u6709\u6613\u53d1\u751f\u4f4e\u9499\u8840\u75c7\u548c\u77ff\u7269\u8d28\u4ee3\u8c22\u5931\u8861\u503e\u5411\u60a3\u8005\uff08\u5982\u6709\u7532\u72b6\u65c1\u817a\u529f\u80fd\u51cf\u9000\u75c7\u53f2\u3001\u7532\u72b6\u817a\u548c\u7532\u72b6\u65c1\u817a\u624b\u672f\u53f2\u3001\u8425\u517b\u4e0d\u826f\u3001\u5c0f\u80a0\u5207\u9664\u3001\u4e25\u91cd\u80be\u529f\u80fd\u635f\u4f24\u5982\u808c\u9150\u6e05\u9664\u7387\u2264<span>30ml\/min<\/span>\u548c<span>\/<\/span>\u6216\u63a5\u53d7\u900f\u6790\u548c\u9499\u8865\u5145\u4e0d\u8db3<span>\/<\/span>\u65e0\u9499\u8865\u5145\uff09\uff0c\u4e34\u5e8a\u9700\u5bc6\u5207\u76d1\u6d4b\u5176\u8840\u808c\u9150\u53ca\u8840\u7535\u89e3\u8d28\u6c34\u5e73\uff08\u5982\u78f7\u548c\u9541\uff09\uff0c\u5e76\u6307\u5bfc\u6b64\u7c7b\u60a3\u8005\u5173\u6ce8\u4f4e\u9499\u8840\u75c7\u7684\u75c7\u72b6\uff0c\u6bcf\u5929\u670d\u7528\u9499<span>500mg<\/span>\u548c\u7ef4\u751f\u7d20<span>D 400IU<\/span>\u4ee5\u6cbb\u7597\u6216\u9884\u9632\u4f4e\u9499\u8840\u75c7\u3002\u5730\u8212\u5355\u6297\u4e0d\u5b9c\u4e0e\u53cc\u81a6\u9178\u76d0\u5408\u5e76\u7528\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u670d\u7528\u514d\u75ab\u6291\u5236\u5242\u6216\u514d\u75ab\u7cfb\u7edf\u53d7\u635f\u7684\u60a3\u8005\u63a5\u53d7\u5730\u8212\u5355\u6297\u6cbb\u7597\u53d1\u751f\u4e25\u91cd\u611f\u67d3\u7684\u98ce\u9669\u53ef\u80fd\u4f1a\u589e\u52a0\uff0c\u7528\u836f\u524d\u9700\u5145\u5206\u8003\u8651\u6548\u76ca<span>&#8211;<\/span>\u98ce\u9669\u6bd4\u3002\u5bf9\u4e8e\u4f7f\u7528\u5730\u8212\u5355\u6297\u53d1\u751f\u4e25\u91cd\u611f\u67d3\u8005\uff0c\u533b\u5e08\u5e94\u8bc4\u4f30\u7ee7\u7eed\u7528\u836f\u7684\u98ce\u9669\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0b\u988c\u9aa8\u574f\u6b7b\uff08\u53ef\u81ea\u53d1\u6027\u53d1\u751f\uff09\u901a\u5e38\u4f34\u968f\u7740\u62d4\u7259\u548c\u5ef6\u8fdf\u6108\u5408\u7684\u5c40\u90e8\u611f\u67d3\u53d1\u751f\u3002\u5730\u8212\u5355\u6297\u5f00\u59cb\u6cbb\u7597\u524d\u5e94\u8fdb\u884c\u5e38\u89c4\u7684\u53e3\u8154\u68c0\u67e5\uff0c\u6cbb\u7597\u5f00\u59cb\u540e\u9700\u4fdd\u6301\u826f\u597d\u7684\u53e3\u8154\u536b\u751f\u3002\u6cbb\u7597\u671f\u95f4\u907f\u514d\u4fb5\u5165\u6027\u9f7f\u79d1\u624b\u672f\u548c\u64cd\u4f5c\uff08\u5982\u62d4\u7259\u3001\u7259\u79d1\u690d\u5165\u3001\u9aa8\u624b\u672f\u7b49\uff09\u3002\u5982\u53d1\u751f\u4e0b\u988c\u9aa8\u574f\u6b7b\uff0c\u9488\u5bf9\u4e0b\u988c\u9aa8\u574f\u6b7b\u7684\u6cbb\u7597\u53ef\u80fd\u53cd\u5012\u52a0\u91cd\u75c5\u60c5\uff0c\u6b64\u65f6\u5e94\u8003\u8651\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u80b2\u9f84\u671f\u5987\u5973\u5728\u63a5\u53d7\u6cbb\u7597\u671f\u95f4\u4ee5\u53ca\u5728\u6700\u540e\u4e00\u5242\u6cbb\u7597\u540e\u81f3\u5c11<span>5<\/span>\u4e2a\u6708\u5185\u91c7\u53d6\u6709\u6548\u7684\u907f\u5b55\u63aa\u65bd\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u5173\u8282\u75db\u3001\u5934\u75db\u3001\u6076\u5fc3\u3001\u80cc\u90e8\u75bc\u75db\u3001\u75b2\u52b3\u548c\u56db\u80a2\u75bc\u75db\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7f8e\u56fd<span>FDA<\/span>\u6279\u51c6\u7684\u5176\u4ed6\u9002\u5e94\u8bc1\u8fd8\u5305\u62ec\uff1a\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u548c\u5b9e\u4f53\u7624\u9aa8\u8f6c\u79fb\u60a3\u8005\u4e2d\u9aa8\u76f8\u5173\u4e8b\u4ef6\u9884\u9632\uff1b\u53cc\u81a6\u9178\u76d0\u96be\u6cbb\u6027\u6076\u6027\u80bf\u7624\u5bfc\u81f4\u7684\u9ad8\u9499\u8840\u75c7\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5730\u8212\u5355\u6297\u7528\u4e8e\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u548c\u5b9e\u4f53\u7624\u9aa8\u8f6c\u79fb\u60a3\u8005\u4e2d\u9aa8\u76f8\u5173\u4e8b\u4ef6\u9884\u9632\u7684\u65b0\u9002\u5e94\u8bc1\u4e0a\u5e02\u7533\u8bf7\u5df2\u4e8e<span>2020<\/span>\u5e74<span>4<\/span>\u6708\u88ab\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6b63\u5f0f\u53d7\u7406\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e09\u3001<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c<span> Anlotinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>8mg<\/span>\u3001<span>10mg<\/span>\u3001<span>12mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u7528\u4e8e\u817a\u6ce1\u72b6\u8f6f\u7ec4\u7ec7\u8089\u7624\u3001\u900f\u660e\u7ec6\u80de\u8089\u7624\u4ee5\u53ca\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u542b\u84bd\u73af\u7c7b\u5316\u7597\u65b9\u6848\u6cbb\u7597\u540e\u8fdb\u5c55\u6216\u590d\u53d1\u7684\u5176\u4ed6\u665a\u671f\u8f6f\u7ec4\u7ec7\u8089\u7624\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>12mg<\/span>\u6bcf\u5929\u4e00\u6b21\u65e9\u9910\u524d\u53e3\u670d\u3002\u8fde\u7eed\u670d\u836f<span>2<\/span>\u5468\uff0c\u505c\u836f<span>1<\/span>\u5468\uff0c\u5373<span>3<\/span>\u5468\uff08<span>21<\/span>\u5929\uff09\u4e3a\u4e00\u4e2a\u6cbb\u7597\u5468\u671f\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u4e0d\u826f\u53cd\u5e94\u3002\u7528\u836f\u671f\u95f4\u5982\u51fa\u73b0\u6f0f\u670d\uff0c\u786e\u8ba4\u8ddd\u4e0b\u6b21\u7528\u836f\u65f6\u95f4\u77ed\u4e8e<span>12<\/span>\u5c0f\u65f6\uff0c\u5219\u4e0d\u518d\u8865\u670d\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c\u6240\u81f4\u7684\u4e0d\u826f\u53cd\u5e94\u53ef\u901a\u8fc7\u5bf9\u75c7\u6cbb\u7597\u3001\u6682\u505c\u7528\u836f\u548c<span>\/<\/span>\u6216\u8c03\u6574\u5242\u91cf\u7b49\u65b9\u5f0f\u5904\u7406\u3002\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7a0b\u5ea6\uff0c\u5efa\u8bae\u6309\u4ee5\u4e0b\u65b9\u6cd5\u8c03\u6574\u5242\u91cf\uff1a\uff08<span>1<\/span>\uff09\u7b2c\u4e00\u6b21\u8c03\u6574\u5242\u91cf\uff1a<span>10mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u8fde\u670d<span>2<\/span>\u5468\uff0c\u505c\u836f<span>1<\/span>\u5468\u3002\uff08<span>2<\/span>\uff09\u7b2c\u4e8c\u6b21\u8c03\u6574\u5242\u91cf\uff1a<span>8mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u8fde\u670d<span>2<\/span>\u5468\uff0c\u505c\u836f<span>1<\/span>\u5468\u3002\u5982<span>8mg<\/span>\u5242\u91cf\u4ecd\u65e0\u6cd5\u8010\u53d7\uff0c\u5219\u6c38\u4e45\u505c\u836f\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53d1\u751f\u975e\u51fa\u8840\u6027\u4e0d\u826f\u53cd\u5e94\u65f6\uff0c\u53c2\u7167\u8868<span>8<\/span>\u7684\u603b\u539f\u5219\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8868<span>8<\/span>&emsp;\u5b89\u7f57\u66ff\u5c3c\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7ea7\u522b\u7684\u5242\u91cf\u8c03\u6574\u603b\u539f\u5219<span><\/span><\/span><\/b>\n<\/p>\n<table class=\"MsoTableGrid\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"1148\" style=\"width:430.65pt;border-collapse:collapse;border:none;\">\n<tbody>\n<tr>\n<td width=\"379\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u826f\u53cd\u5e94\u7ea7\u522b<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08<span>NCI CTCAE 5.0<\/span>\uff09<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"379\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ed9\u836f\u65f6\u95f4<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"391\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u8c03\u6574\u539f\u5219<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"379\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"379\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7528\u836f\uff0c\u5f85\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u5230\uff1c<span>2<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"391\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u540e\u7ee7\u7eed\u7ed9\u836f\uff1b\u5982<span>2<\/span>\u5468\u540e\u4ecd\u672a\u6062\u590d\uff0c\u5219\u8003\u8651\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"379\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"379\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7528\u836f\uff0c\u5f85\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u5230\uff1c<span>2<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"391\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u540e\u7ee7\u7eed\u7ed9\u836f\uff1b\u5982<span>2<\/span>\u5468\u540e\u4ecd\u672a\u6062\u590d\uff0c\u5219\u8003\u8651\u6c38\u4e45\u505c\u836f\uff1b\u6216\u6839\u636e\u533b\u5e08\u5224\u65ad\u8003\u8651\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">NCI CTCAE 5.0<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\u5e38\u89c1\u836f\u7269\u6bd2\u6027\u53cd\u5e94\u5206\u7ea7\u6807\u51c6<span>5.0<\/span>\u7248\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51fa\u8840\u662f\u5b89\u7f57\u66ff\u5c3c\u6700\u91cd\u8981\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5177\u6709\u51fa\u8840\u98ce\u9669\u3001\u51dd\u8840\u529f\u80fd\u5f02\u5e38\u60a3\u8005\u5e94\u614e\u7528\u5b89\u7f57\u66ff\u5c3c\uff0c\u670d\u836f\u671f\u95f4\u5e94\u4e25\u5bc6\u76d1\u6d4b\u51dd\u8840\u9176\u539f\u65f6\u95f4\u548c<span>INR<\/span>\u3002\u4e00\u65e6\u51fa\u73b0<span>2<\/span>\u7ea7\u51fa\u8840\u4e8b\u4ef6\u5e94\u6682\u505c\u7528\u836f\uff0c\u5982<span>2<\/span>\u5468\u5185\u80fd\u6062\u590d\u81f3\uff1c<span>2<\/span>\u7ea7\u8005\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u7ee7\u7eed\u7528\u836f\uff1b\u5982\u518d\u6b21\u51fa\u73b0\uff0c\u5e94\u8003\u8651\u6c38\u4e45\u505c\u836f\u3002\u4e00\u65e6\u51fa\u73b0<span>3<\/span>\u7ea7\u6216\u4ee5\u4e0a\u7684\u51fa\u8840\u4e8b\u4ef6\uff0c\u6c38\u4e45\u505c\u836f\u3002\u5f53\u53d1\u751f\u51fa\u8840\u7684\u4e0d\u826f\u53cd\u5e94\u65f6\u53c2\u7167\u8868<span>9<\/span>\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8868<span>9<\/span>&emsp;\u5b89\u7f57\u66ff\u5c3c\u53d1\u751f<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51fa\u8840\u4e0d\u826f\u53cd\u5e94\u65f6\u7684\u5242\u91cf\u8c03\u6574\u539f\u5219<span><\/span><\/span><\/b>\n<\/p>\n<table class=\"MsoTableGrid\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\" style=\"border-collapse:collapse;border:none;\">\n<tbody>\n<tr>\n<td width=\"336\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51fa\u8840\u4e8b\u4ef6<sup><span>*<\/span><\/sup><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"801\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u8c03\u6574\u539f\u5219<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"336\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"801\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7528\u836f\uff0c\u5e76\u91c7\u53d6\u79ef\u6781\u5bf9\u75c7\u6cbb\u7597\u5904\u7406\uff1b<span>2<\/span>\u5468\u5185\u80fd\u6062\u590d\u81f3\uff1c<span>2<\/span>\u7ea7\u65f6\uff0c\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u7ee7\u7eed\u7528\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"336\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2265<span>3<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"801\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f\uff0c\u5e76\u91c7\u53d6\u7d27\u6025\u533b\u5b66\u5e72\u9884\u5904\u7406<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\" style=\"text-indent:28.3pt;\">\n\t<sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">*<\/span><\/sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51fa\u8840\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\uff1a\u54af\u8840\u3001\u6d88\u5316\u9053\u51fa\u8840\u3001\u9f3b\u51fa\u8840\u3001\u652f\u6c14\u7ba1\u51fa\u8840\u3001\u7259\u9f88\u51fa\u8840\u3001\u8089\u773c\u8840\u5c3f\u3001\u4fbf\u6f5c\u8840\u548c\u8111\u51fa\u8840\u7b49\u3002<b><span><\/span><\/b><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d<span>4<\/span>\u5468\u5185\u51fa\u73b0\u2265<span>CTCAE3<\/span>\u7ea7\u7684\u4efb\u4f55\u51fa\u8840\u4e8b\u4ef6\u3001\u5b58\u5728\u672a\u6108\u5408\u521b\u53e3\u3001\u6e83\u75a1\u6216\u9aa8\u6298\u548c<span>6<\/span>\u4e2a\u6708\u5185\u53d1\u751f\u8fc7\u52a8<span>\/<\/span>\u9759\u8109\u8840\u6813\u4e8b\u4ef6\u5982\u8111\u8840\u7ba1\u610f\u5916\uff08\u5305\u62ec\u6682\u65f6\u6027\u7f3a\u8840\u6027\u53d1\u4f5c\uff09\u3001\u6df1\u9759\u8109\u8840\u6813\u53ca\u80ba\u6813\u585e\u7684\u60a3\u8005\uff0c\u5e94\u5728\u533b\u5e08\u6307\u5bfc\u4e0b\u7528\u836f\uff0c\u5bf9\u5408\u7528\u534e\u6cd5\u6797\u7684\u60a3\u8005\u5e94\u6bcf<span>1<\/span>\uff5e<span>2<\/span>\u5468\u76d1\u6d4b\u51dd\u8840\u9176\u539f\u65f6\u95f4\u548c<span>INR<\/span>\u503c\uff0c\u5e76\u6ce8\u610f\u4e34\u5e8a\u51fa\u8840\u8ff9\u8c61\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9ad8\u8840\u538b\u662f\u5b89\u7f57\u66ff\u5c3c\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u7528\u836f\u671f\u95f4\u5e94\u5bc6\u5207\u76d1\u6d4b\u8840\u538b\uff0c\u9ad8\u8840\u538b\u591a\u5728\u5f00\u59cb\u670d\u836f\u540e<span>2<\/span>\u5468\u5185\u51fa\u73b0\uff0c\u5229\u5c3f\u5242\u3001\u03b2\u53d7\u4f53\u963b\u6ede\u5242\u548c\u9499\u901a\u9053\u62ee\u6297\u5242\u7b49\u5e38\u89c4\u964d\u8840\u538b\u836f\u7269\u4e00\u822c\u53ef\u4ee5\u63a7\u5236\u3002\u5f00\u59cb\u7528\u836f\u7684\u524d<span>6<\/span>\u5468\u5e94\u6bcf\u5929\u76d1\u6d4b\u8840\u538b\uff0c\u540e\u7eed\u7528\u836f\u671f\u95f4\u6bcf\u5468\u76d1\u6d4b\u8840\u538b<span>2<\/span>\uff5e<span>3<\/span>\u6b21\uff0c\u53d1\u73b0\u8840\u538b\u5347\u9ad8\u6216\u5934\u75db\u5934\u6655\u75c7\u72b6\u5e94\u79ef\u6781\u4e0e\u533b\u5e08\u6c9f\u901a\u5e76\u5728\u533b\u5e08\u6307\u5bfc\u4e0b\u63a5\u53d7\u964d\u538b\u836f\u7269\u6cbb\u7597\uff0c\u6682\u505c\u5b89\u7f57\u66ff\u5c3c\u6cbb\u7597\u6216\u5242\u91cf\u8c03\u6574\u3002\u5f53\u53d1\u751f<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u9ad8\u8840\u538b\uff08\u6536\u7f29\u538b\u2265<span>180mmHg<\/span>\u6216\u8212\u5f20\u538b\u2265<span>110mmHg<\/span>\uff09\uff0c\u5e94\u6682\u505c\u7528\u836f\uff1b\u5982\u6062\u590d\u7528\u836f\u540e\u518d\u6b21\u51fa\u73b0<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u9ad8\u8840\u538b\uff0c\u5e94\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u540e\u7ee7\u7eed\u7528\u836f\u3002\u5982<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u9ad8\u8840\u538b\u6301\u7eed\uff0c\u5efa\u8bae\u505c\u836f\u3002\u51fa\u73b0\u9ad8\u8840\u538b\u5371\u8c61\u7684\u60a3\u8005\uff0c\u5e94\u7acb\u5373\u505c\u836f\u5e76\u63a5\u53d7\u5fc3\u8840\u7ba1\u4e13\u79d1\u51b6\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c\u53ef\u5ef6\u957f<span>QTc<\/span>\u95f4\u671f\uff0c<span>QTc<\/span>\u95f4\u671f\u5ef6\u957f\u53ef\u5bfc\u81f4\u5ba4\u6027\u5feb\u901f\u6027\u5fc3\u5f8b\u5931\u5e38\uff08\u5982\u5c16\u7aef\u626d\u8f6c\u578b\u5ba4\u6027\u5fc3\u52a8\u8fc7\u901f\uff09\uff0c\u6b7b\u4ea1\u98ce\u9669\u589e\u52a0\u3002\u60a3\u6709\u5148\u5929\u6027\u957f<span>QTc<\/span>\u95f4\u671f\u7efc\u5408\u5f81\u7684\u60a3\u8005\u5e94\u907f\u514d\u7528\u836f\uff0c\u60a3\u6709\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\u3001\u8840\u7535\u89e3\u8d28\u5f02\u5e38\u6216\u4f7f\u7528\u5df2\u77e5\u80fd\u591f\u5ef6\u957f<span>QTc<\/span>\u95f4\u671f\u836f\u7269\u7684\u60a3\u8005\u5e94\u5b9a\u671f\uff08\u6bcf<span>3<\/span>\uff5e<span>6<\/span>\u5468\uff09\u63a5\u53d7\u5fc3\u7535\u56fe\u548c\u8840\u7535\u89e3\u8d28\u7684\u68c0\u6d4b\u3002\u8fde\u7eed\u4e24\u6b21\u72ec\u7acb\u5fc3\u7535\u56fe\u68c0\u6d4b<span>QTc<\/span>\u95f4\u671f\uff1e<span>500ms<\/span>\u7684\u60a3\u8005\u5e94\u6682\u505c\u7528\u836f\uff0c\u76f4\u81f3<span>QTc<\/span>\u95f4\u671f\u2264<span>480ms<\/span>\u6216\u964d\u81f3\u57fa\u7ebf\u6c34\u5e73\uff08\u5f53\u57fa\u7ebf<span>QTc<\/span>\u95f4\u671f\uff1e<span>480ms<\/span>\uff09\uff0c\u5e94\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u7528\u836f\u3002\u5bf9\u4e8e\u51fa\u73b0\u4efb\u4f55\u7ea7\u522b\u7684<span>QTc<\/span>\u95f4\u671f\u5ef6\u957f\uff08\u2265<span>450ms<\/span>\uff09\u5e76\u4f34\u6709\u5c16\u7aef\u626d\u8f6c\u578b\u5ba4\u6027\u5fc3\u52a8\u8fc7\u901f\u3001\u591a\u5f62\u6027\u5ba4\u6027\u5fc3\u52a8\u8fc7\u901f\u3001\u4e25\u91cd\u5fc3\u5f8b\u5931\u5e38\u7684\u60a3\u8005\u5e94\u6c38\u4e45\u505c\u836f\uff0c\u5e76\u53ca\u65f6\u53bb\u5fc3\u8840\u7ba1\u4e13\u79d1\u5c31\u8bca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u7840\u5fc3\u529f\u80fd\u5f02\u5e38\u7684\u60a3\u8005\uff0c\u5e94\u6bcf<span>6<\/span>\u5468\u505a\u5fc3\u810f\u529f\u80fd\u68c0\u67e5\uff0c\u5982\u51fa\u73b0\u2162\uff5e\u2163\u7ea7\u5fc3\u529f\u80fd\u4e0d\u5168\u6216\u5fc3\u810f\u5f69\u8d85\u663e\u793a\u5de6\u5ba4\u5c04\u8840\u5206\u6570\uff1c<span>50%<\/span>\u7684\u60a3\u8005\u5e94\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80bf\u7624\u60a3\u8005\u80ba\u53ca\u80f8\u819c\u4e0b\u75c5\u7076\u9000\u7f29\u5b58\u5728\u81ea\u53d1\u6027\u6c14\u80f8\u98ce\u9669\uff0c\u5b89\u7f57\u66ff\u5c3c\u6cbb\u7597\u671f\u95f4\u6216\u6cbb\u7597\u540e\u7a81\u53d1\u80f8\u75db\u6216\u547c\u5438\u56f0\u96be\u7b49\u75c7\u72b6\u5e94\u7acb\u5373\u5c31\u533b\uff0c\u786e\u8ba4\u6c14\u80f8\u540e\u5e94\u884c\u80f8\u8154\u95ed\u5f0f\u5f15\u6d41\u672f\u6216\u5176\u4ed6\u533b\u5b66\u5e72\u9884\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c\u53ef\u5f15\u8d77\u8f6c\u6c28\u9176\u6216\u603b\u80c6\u7ea2\u7d20\u5347\u9ad8\u3002\u8f7b\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u614e\u7528\uff0c\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7981\u7528\u3002\u670d\u7528\u5b89\u7f57\u66ff\u5c3c\u671f\u95f4\u5e94\u76d1\u6d4b\u8f6c\u6c28\u9176\u548c\u80c6\u7ea2\u7d20\uff0c\u5efa\u8bae\u5728\u6cbb\u7597\u5f00\u59cb\u524d\u3001\u6bcf\u4e2a\u6cbb\u7597\u5468\u671f\u4ee5\u53ca\u4e34\u5e8a\u9700\u8981\u65f6\u68c0\u6d4b\u809d\u529f\u80fd\uff08<span>ALT<\/span>\u3001<span>AST<\/span>\u3001\u80c6\u7ea2\u7d20\uff09\u3002\u5f53\u60a3\u8005\u53d1\u751f<span>2<\/span>\u7ea7\u809d\u529f\u80fd\u5f02\u5e38\u65f6\uff0c\u5e94\u589e\u52a0\u68c0\u6d4b\u9891\u7387\uff0c\u5f53\u60a3\u8005\u53d1\u751f<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u8f6c\u6c28\u9176\u6216\u603b\u80c6\u7ea2\u7d20\u5347\u9ad8\u65f6\uff0c\u5e94\u6682\u505c\u7528\u836f\uff0c\u540c\u65f6\u6bcf\u5468\u68c0\u6d4b\u8f6c\u6c28\u9176\u53ca\u603b\u80c6\u7ea2\u7d20<span>2<\/span>\uff5e<span>3<\/span>\u6b21\uff0c<span>2<\/span>\u5468\u5185\u6062\u590d\u81f3\uff1c<span>2<\/span>\u7ea7\u540e\u53ef\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u7ee7\u7eed\u7528\u836f\uff1b\u5982\u4e0b\u8c03\u5242\u91cf\u540e\u4ecd\u51fa\u73b0<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u8f6c\u6c28\u9176\u6216\u80c6\u7ea2\u7d20\u6301\u7eed\u5347\u9ad8\uff0c\u5efa\u8bae\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u7840\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u614e\u7528\u5b89\u7f57\u66ff\u5c3c\uff0c\u5efa\u8bae\u6bcf<span>6<\/span>\u5468\u68c0\u67e5\u5c3f\u5e38\u89c4\uff0c\u5bf9\u8fde\u7eed\u4e24\u6b21\u5c3f\u86cb\u767d\uff08<span>++<\/span>\uff09\u4ee5\u4e0a\u8005\u8fdb\u884c<span>24<\/span>\u5c0f\u65f6\u5c3f\u86cb\u767d\u5b9a\u91cf\u68c0\u6d4b\uff0c\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7ea7\u522b\u91c7\u53d6\u6682\u505c\u7528\u836f\u3001\u5242\u91cf\u8c03\u6574\u548c\u6c38\u4e45\u505c\u836f\u7b49\u5904\u7406\u63aa\u65bd\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u5b89\u7f57\u66ff\u5c3c\u6cbb\u7597\u5f00\u59cb\u524d\uff0c\u5efa\u8bae\u68c0\u6d4b\u57fa\u7ebf\u7532\u72b6\u817a\u529f\u80fd\uff0c\u5728\u6cbb\u7597\u671f\u95f4\uff0c\u5bf9\u6240\u6709\u60a3\u8005\u5e94\u5bc6\u5207\u89c2\u5bdf\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u7684\u4f53\u5f81\u548c\u75c7\u72b6\uff0c\u5b9a\u671f\u8fdb\u884c\u7532\u72b6\u817a\u529f\u80fd\u7684\u5b9e\u9a8c\u5ba4\u76d1\u6d4b\uff0c\u5bf9\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u7684\u60a3\u8005\u8fdb\u884c\u89c4\u8303\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c\u53ef\u5bfc\u81f4\u8179\u6cfb\uff0c\u6ce8\u610f\u8bc4\u4f30\u662f\u5426\u6709\u8131\u6c34\u6216\u7535\u89e3\u8d28\u5931\u8861\uff0c\u5fc5\u8981\u65f6\u8003\u8651\u9759\u8109\u8865\u6db2\uff0c\u4f7f\u7528\u6d1b\u54cc\u4e01\u80fa\u3001\u76ca\u751f\u83cc\u548c\u8499\u8131\u77f3\u6563\u6cbb\u7597\u3002\u4e25\u91cd\u65f6\u4e5f\u53ef\u8003\u8651\u9884\u9632\u6027\u6297\u751f\u7d20\u6cbb\u7597\u5e76\u52a0\u7528\u751f\u957f\u6291\u7d20\u3002\u5bf9\u53d1\u751f\u4e25\u91cd\u6216\u6301\u7eed\u6027\u8179\u6cfb\u751a\u81f3\u8131\u6c34\u7684\u60a3\u8005\uff0c\u9700\u8981\u9274\u522b\u5176\u4ed6\u8179\u6cfb\u539f\u56e0\uff08\u80a0\u9053\u83cc\u7fa4\u7d0a\u4e71\u3001\u514d\u75ab\u529f\u80fd\u4f4e\u4e0b\u3001\u7c7b\u764c\u7efc\u5408\u5f81\u7b49\uff09\uff0c\u53ef\u91c7\u53d6\u6682\u505c\u7528\u836f\u3001\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u76f4\u81f3\u6c38\u4e45\u505c\u836f\u63aa\u65bd\uff0c\u5e76\u6839\u636e\u8179\u6cfb\u539f\u56e0\u79ef\u6781\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">12.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c\u6cbb\u7597\u53ef\u4ee5\u51fa\u73b0\u53e3\u8154\u75bc\u75db\u3001\u53e3\u8154\u9ecf\u819c\u708e\u548c\u7259\u75bc\u3002\u7259\u9f88\u3001\u53e3\u8154\u80bf\u75db\u60a3\u8005\u5e94\u4fdd\u6301\u53e3\u8154\u6e05\u6d01\u3001\u6b62\u75db\uff0c\u9632\u6cbb\u591a\u91cd\u611f\u67d3\uff0c\u9632\u6b62\u53e3\u8154\u9ecf\u819c\u708e\u8fdb\u4e00\u6b65\u52a0\u91cd\u3002\u63a8\u8350\u4f7f\u7528\u542b\u5229\u591a\u5361\u56e0\u3001\u78b3\u9178\u6c22\u94a0\u6216\u6c2f\u5df1\u5b9a\u7b49\u6210\u5206\u7684\u542b\u6f31\u5242\u6216\u6d82\u5242\u5bf9\u75c7\u5904\u7406\uff0c\u4fc3\u8fdb\u53e3\u8154\u9ecf\u819c\u6108\u5408\u3002\u6ce8\u610f\u5747\u8861\u8425\u517b\u548c\u6c34\u7684\u6444\u53d6\uff0c\u81b3\u98df\u4e2a\u4f53\u5316\uff0c\u907f\u514d\u70ed\u3001\u8f9b\u8fa3\u98df\u7269\uff0c\u5fcc\u70df\u9152\uff0c\u7981\u7528\u542b\u9152\u7cbe\u7684\u542b\u6f31\u5242\uff0c\u5fc5\u8981\u65f6\u53ef\u5230\u53e3\u8154\u4e13\u79d1\u5c31\u8bca\u3002\u53d1\u751f\u7259\u9f88\u3001\u53e3\u8154\u80bf\u75db\u65f6\uff0c\u53ef\u91c7\u53d6\u6682\u505c\u7528\u836f\u3001\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u76f4\u81f3\u6c38\u4e45\u505c\u836f\u63aa\u65bd\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">13.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u624b\u8db3\u7efc\u5408\u5f81\u591a\u5728\u5b89\u7f57\u66ff\u5c3c\u7ed9\u836f<span>2<\/span>\u5468\u5185\u51fa\u73b0\uff0c\u8868\u73b0\u4e3a\u624b\u8db3\u638c\u5e95\u90e8\u4f4d\u76ae\u80a4\u80bf\u80c0\u3001\u5265\u843d\u3001\u6c34\u6ce1\u3001\u76b2\u88c2\u3001\u51fa\u8840\u6216\u7ea2\u6591\u7684\u590d\u5408\u8868\u73b0\uff0c\u5e38\u4f34\u6709\u75bc\u75db\u3002<span>2<\/span>\u7ea7\u624b\u8db3\u7efc\u5408\u5f81\u60a3\u8005\u5e94\u91c7\u53d6\u5bf9\u75c7\u6cbb\u7597\u5904\u7406\uff0c\u5305\u62ec\u52a0\u5f3a\u76ae\u80a4\u62a4\u7406\uff0c\u4fdd\u6301\u76ae\u80a4\u6e05\u6d01\uff0c\u907f\u514d\u7ee7\u53d1\u611f\u67d3\uff0c\u907f\u514d\u538b\u529b\u548c\u6469\u64e6\uff1b\u5c40\u90e8\u4f7f\u7528\u542b\u5c3f\u7d20\u548c\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6210\u5206\u7684\u4e73\u6db2\u6216\u6da6\u6ed1\u5242\uff1b\u53d1\u751f\u611f\u67d3\u65f6\u5c40\u90e8\u4f7f\u7528\u6297\u771f\u83cc\u836f\u6216\u6297\u751f\u7d20\u6cbb\u7597\uff0c\u5efa\u8bae\u5728\u76ae\u80a4\u4e13\u79d1\u533b\u5e08\u6307\u5bfc\u4e0b\u4f7f\u7528\u3002\u5982\u51fa\u73b0\u2265<span>3<\/span>\u7ea7\u7684\u624b\u8db3\u7efc\u5408\u5f81\uff0c\u5e94\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u540e\u7ee7\u7eed\u7528\u836f\u3002\u5982\u4e0d\u826f\u53cd\u5e94\u4ecd\u6301\u7eed\uff0c\u5e94\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">14.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51fa\u73b0\u9ad8\u8102\u8840\u75c7\u7684\u60a3\u8005\u5efa\u8bae\u8c03\u6574\u4e3a\u4f4e\u8102\u996e\u98df\u3002\u2265<span>2<\/span>\u7ea7\u7684\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\uff08\u2265<span>7.75mmol\/L<\/span>\uff09\u6216\u2265<span>2<\/span>\u7ea7\u7684\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\uff08\u2265<span>2.5<\/span>\u500d<span>ULN<\/span>\uff09\uff0c\u5e94\u4f7f\u7528\u7f9f\u7532\u57fa\u620a\u4e8c\u9170\u8f85\u9176<span>A<\/span>\u8fd8\u539f\u9176\u6291\u5236\u5242\u7b49\u964d\u8840\u8102\u836f\u7269\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">15.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c1a\u4e0d\u786e\u5b9a\u5b89\u7f57\u66ff\u5c3c\u662f\u5426\u53ef\u5bfc\u81f4\u766b\u75eb\u6216\u589e\u52a0\u766b\u75eb\u98ce\u9669\uff0c\u65e2\u5f80\u6709\u766b\u75eb\u75c5\u53f2\u7684\u60a3\u8005\u5e94\u614e\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">16.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53ef\u9006\u6027\u540e\u90e8\u767d\u8d28\u8111\u75c5\u7efc\u5408\u5f81\u5728<span>VEGFR<\/span>\u6291\u5236\u5242\u7c7b\u836f\u7269\u6cbb\u7597\u80bf\u7624\u4e2d\u6709\u62a5\u9053\uff0c\u5e76\u4e14\u53ef\u80fd\u81f4\u547d\u3002\u5728\u5b89\u7f57\u66ff\u5c3c\u7814\u7a76\u4e2d\u5c1a\u672a\u62a5\u544a\u6b64\u7c7b\u4e8b\u4ef6\u53d1\u751f\uff0c\u5728\u5b9e\u9645\u4f7f\u7528\u8fc7\u7a0b\u4e2d\uff0c\u5e94\u5bc6\u5207\u76d1\u6d4b\u76f8\u5173\u7684\u75c7\u72b6\u548c\u4f53\u5f81\uff0c\u4e00\u65e6\u53d1\u751f\u53ef\u9006\u6027\u540e\u90e8\u767d\u8d28\u8111\u75c5\u7efc\u5408\u5f81\u7684\u60a3\u8005\u5e94\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">17.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c\u53ef\u80fd\u5f71\u54cd\u60a3\u8005\u4f24\u53e3\u6108\u5408\uff0c\u5efa\u8bae\u51c6\u5907\u63a5\u53d7\u5916\u79d1\u624b\u672f\u7684\u60a3\u8005\u6682\u505c\u7ed9\u836f\u4ee5\u9884\u9632\u672f\u540e\u4f24\u53e3\u6108\u5408\u5ef6\u8fdf\uff0c\u672f\u540e\u4f55\u65f6\u6062\u590d\u7528\u836f\u7531\u4e34\u5e8a\u533b\u5e08\u6839\u636e\u60a3\u8005\u5177\u4f53\u60c5\u51b5\u5224\u65ad\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">18.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u7f3a\u4e4f<span>18<\/span>\u5c81\u4ee5\u4e0b\u60a3\u8005\u5e94\u7528\u5b89\u7f57\u66ff\u5c3c\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u8d44\u6599\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2265<span>65<\/span>\u5c81<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8001\u5e74\u60a3\u8005\u4f7f\u7528\u5b89\u7f57\u66ff\u5c3c\u65f6\uff0c\u65e0\u9700\u8c03\u6574\u7528\u836f\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">19.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80b2\u9f84\u671f\u5973\u6027\u5728\u63a5\u53d7\u5b89\u7f57\u66ff\u5c3c\u6cbb\u7597\u671f\u95f4\u548c\u6cbb\u7597\u7ed3\u675f\u81f3\u5c11<span>6<\/span>\u4e2a\u6708\u5185\u5e94\u91c7\u53d6\u6709\u6548\u7684\u907f\u5b55\u63aa\u65bd\uff0c\u598a\u5a20\u671f\u53ca\u54fa\u4e73\u671f\u5987\u5973\u7981\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">20.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u5b89\u7f57\u66ff\u5c3c\u907f\u514d\u4e0e<span>CYP1A2<\/span>\u548c<span>CYP3A4\/5<\/span>\u7684\u5f3a\u6291\u5236\u5242\u53ca\u5f3a\u8bf1\u5bfc\u5242\u5408\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">21.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c\u88ab\u63a8\u8350\u4f5c\u4e3a\u665a\u671f\u6216\u4e0d\u53ef\u5207\u9664\u8f6f\u7ec4\u7ec7\u8089\u7624\u7684\u4e8c\u7ebf\u6cbb\u7597\u836f\u7269\u3001\u665a\u671f\u6216\u4e0d\u53ef\u5207\u9664\u817a\u6ce1\u72b6\u8f6f\u7ec4\u7ec7\u8089\u7624\u7684\u4e00\u7ebf\u6cbb\u7597\u836f\u7269\u3002<span><\/span><\/span>\n<\/p>\n<p><b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><br \/>\n<\/span><\/b> <\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5934\u9888\u90e8\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e00\u3001\u5c3c\u59a5\u73e0\u5355\u6297<span> Nimotuzumab <\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>50mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0e\u653e\u7597\u8054\u5408\u6cbb\u7597<span>EGFR<\/span>\u57fa\u56e0\u9633\u6027\u8868\u8fbe\u7684\u2162\uff5e\u2163\u671f\u9f3b\u54bd\u764c\u3002<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9996\u6b21\u7ed9\u836f\u5e94\u5728\u653e\u5c04\u6cbb\u7597\u7684\u7b2c\u4e00\u5929\uff0c\u5e76\u5728\u653e\u5c04\u6cbb\u7597\u5f00\u59cb\u524d\u5b8c\u6210\u3002\u4e4b\u540e\u6bcf\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u5171<span>8<\/span>\u5468\uff0c\u60a3\u8005\u540c\u65f6\u63a5\u53d7\u6807\u51c6\u7684\u653e\u5c04\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u76ae\u80a4\u53cd\u5e94\u548c\u8179\u6cfb\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c1a\u672a\u786e\u5b9a<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u4f7f\u7528\u672c\u54c1\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u7531\u719f\u7ec3\u638c\u63e1<span>EGFR<\/span>\u68c0\u6d4b\u6280\u672f\u7684\u4e13\u804c\u4eba\u5458\u8fdb\u884c<span>EGFR<\/span>\u8868\u8fbe\u6c34\u5e73\u7684\u68c0\u9a8c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c3c\u59a5\u73e0\u5355\u6297\u51bb\u878d\u540e\u6297\u4f53\u5927\u90e8\u5206\u6d3b\u6027\u5c06\u4e27\u5931\uff0c\u6545\u5728\u50a8\u5b58\u8fc7\u7a0b\u4e2d\u4e25\u7981\u51b7\u51bb\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c3c\u59a5\u73e0\u5355\u6297\u914d\u5236\u7684\u6eb6\u6db2\u5728\u8f93\u6db2\u5bb9\u5668\u4e2d<span>2<\/span>\uff5e<span>8<\/span>\u2103\u65f6\uff0c\u5176\u7269\u7406\u548c\u5316\u5b66\u7a33\u5b9a\u6027\u53ef\u4fdd\u6301<span>12<\/span>\u5c0f\u65f6\uff0c\u5728\u5ba4\u6e29\u4e0b\u53ef\u4fdd\u6301<span>8<\/span>\u5c0f\u65f6\u3002\u50a8\u5b58\u65f6\u95f4\u8d85\u8fc7\u4e0a\u8ff0\u65f6\u95f4\uff0c\u4e0d\u5b9c\u7ee7\u7eed\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b55\u5987\u6216\u6ca1\u6709\u91c7\u53d6\u6709\u6548\u907f\u5b55\u63aa\u65bd\u7684\u5987\u5973\u5e94\u614e\u7528\u3002\u672c\u54c1\u5c5e\u4e8e<span>IgG1<\/span>\u7c7b\u6297\u4f53\uff0c\u7531\u4e8e\u4eba<span>IgG1<\/span>\u80fd\u591f\u5206\u6ccc\u81f3\u4e73\u6c41\uff0c\u5efa\u8bae\u54fa\u4e73\u671f\u5987\u5973\u5728\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u4ee5\u53ca\u5728\u6700\u540e\u4e00\u6b21\u7ed9\u836f\u540e<span>60<\/span>\u5929\u5185\u505c\u6b62\u54fa\u4e73\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u7279\u745e\u666e\u5229\u5355\u6297 <span>Toripalimab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">80mg<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\uff08<span>2ml<\/span>\uff09<span>\/<\/span>\u74f6\u3001<span>240mg<\/span>\uff08<span>6ml<\/span>\uff09<span>\/<\/span>\u74f6<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e8c\u7ebf\u53ca\u4ee5\u4e0a\u7cfb\u7edf\u6cbb\u7597\u5931\u8d25\u7684\u590d\u53d1<span>\/<\/span>\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u665a\u671f\u9f3b\u54bd\u764c\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>3mg\/kg<\/span>\uff0c\u9759\u8109\u8f93\u6ce8\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff0c\u76f4\u5230\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u90e8\u5206\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u7684\u60a3\u8005\u53ef\u80fd\u5b58\u5728\u80bf\u7624\u975e\u5178\u578b\u53cd\u5e94\uff0c\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u5728\u5f71\u50cf\u5b66\u4e0a\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u826f\u53cd\u5e94\u4e3a\u8d2b\u8840\u3001<span>ALT<\/span>\u5347\u9ad8\u3001\u4e4f\u529b\u3001<span>AST<\/span>\u5347\u9ad8\u3001\u76ae\u75b9\u3001\u53d1\u70ed\u3001\u8840\u4fc3\u7532\u72b6\u817a\u6fc0\u7d20\u5347\u9ad8\u3001\u767d\u7ec6\u80de\u8ba1\u6570\u51cf\u5c11\u3001\u54b3\u55fd\u3001\u7619\u75d2\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u75c7\u3001\u98df\u6b32\u4e0b\u964d\u3001\u8840\u7cd6\u5347\u9ad8\u548c\u8840\u80c6\u7ea2\u7d20\u5347\u9ad8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u5927\u591a\u6570\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u662f\u53ef\u9006\u7684\uff0c\u5e76\u4e14\u53ef\u901a\u8fc7\u4e2d\u65ad\u7279\u745e\u666e\u5229\u5355\u6297\u3001\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u548c\uff0f\u6216\u652f\u6301\u6cbb\u7597\u6765\u5904\u7406\u3002\u5bf9\u4e8e\u5927\u90e8\u5206<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u53ca\u67d0\u4e9b\u7279\u5b9a\u7684<span>2<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u9700\u6682\u505c\u7ed9\u836f\u3002\u5bf9\u4e8e<span>4<\/span>\u7ea7\u53ca\u67d0\u4e9b\u7279\u5b9a\u7684<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u9700\u6c38\u4e45\u505c\u836f\u3002\u5bf9\u4e8e<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u53ca\u67d0\u4e9b\u7279\u5b9a\u7684<span>2<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u7ed9\u4e88<span>1<\/span>\uff5e<span>2mg\/<\/span>\uff08<span>kg<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2022<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">d<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff09\u5f3a\u7684\u677e\u7b49\u6548\u5242\u91cf\u53ca\u5176\u4ed6\u6cbb\u7597\uff0c\u76f4\u81f3\u6539\u5584\u5230\u2264<span>1<\/span>\u7ea7\u3002\u7cd6\u76ae\u8d28\u6fc0\u7d20\u9700\u81f3\u5c11\u4e00\u4e2a\u6708\u7684\u65f6\u95f4\u9010\u6e10\u51cf\u91cf\u76f4\u81f3\u505c\u836f\uff0c\u5feb\u901f\u51cf\u91cf\u53ef\u80fd\u5f15\u8d77\u4e0d\u826f\u53cd\u5e94\u6076\u5316\u6216\u590d\u53d1\u3002\u5982\u679c\u4e0d\u826f\u53cd\u5e94\u5728\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u540e\u7ee7\u7eed\u6076\u5316\u6216\u65e0\u6539\u5584\uff0c\u5219\u5e94\u589e\u52a0\u975e\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7c7b\u522b\u7684\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e<span>4<\/span>\u7ea7\u53ca\u67d0\u4e9b\u7279\u5b9a\u7684<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ca\u4efb\u4f55\u590d\u53d1\u6027<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u672b\u6b21\u7ed9\u836f\u540e<span>12<\/span>\u5468\u5185<span>2<\/span>\uff5e<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u672a\u6539\u5584\u5230<span>0<\/span>\uff5e<span>1<\/span>\u7ea7\uff08\u9664\u5916\u5185\u5206\u6ccc\u75be\u75c5\uff09\uff0c\u4ee5\u53ca\u672b\u6b21\u7ed9\u836f<span>12<\/span>\u5468\u5185\u7cd6\u76ae\u8d28\u6fc0\u7d20\u672a\u80fd\u964d\u81f3<span>\u226410mg\/d<\/span>\u5f3a\u7684\u677e\u7b49\u6548\u5242\u91cf\uff0c\u5e94\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7981\u5fcc\uff1a\uff08<span>1<\/span>\uff09\u7981\u6b62\u7528\u4e8e\u5bf9\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\u6d3b\u6027\u6210\u5206\u6216\u8f85\u6599\u5b58\u5728\u8d85\u654f\u53cd\u5e94\u7684\u60a3\u8005\u3002\uff08<span>2<\/span>\uff09\u4e0d\u53ef\u4e0e\u5176\u4ed6\u836f\u54c1\u6df7\u5408\u6216\u7a00\u91ca\uff0c\u836f\u74f6\u4e2d\u5269\u4f59\u7684\u836f\u7269\u4e0d\u53ef\u91cd\u590d\u4f7f\u7528\u3002\uff08<span>3<\/span>\uff09\u4e0d\u5f97\u91c7\u7528\u9759\u8109\u63a8\u6ce8\u6216\u5355\u6b21\u5feb\u901f\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56e0\u53ef\u80fd\u5e72\u6270\u672c\u54c1\u836f\u6548\u5b66\u6d3b\u6027\uff0c\u5e94\u907f\u514d\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002\u4f46\u662f\u5982\u679c\u4e3a\u4e86\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u540e\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e09\u3001\u5361\u745e\u5229\u73e0\u5355\u6297 <span>Camrelizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7c89\u9488\u5242\uff1a<span>200mg\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e8c\u7ebf\u53ca\u4ee5\u4e0a\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u665a\u671f\u9f3b\u54bd\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u8054\u5408\u987a\u94c2\u548c\u5409\u897f\u4ed6\u6ee8\u7528\u4e8e\u5c40\u90e8\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u5c40\u90e8\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>200mg\/<\/span>\u6b21\uff0c\u9759\u8109\u8f93\u6ce8\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c\u76f4\u5230\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u5f71\u50cf\u5b66\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u533b\u751f\u53ef\u57fa\u4e8e\u5bf9\u60a3\u8005\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u8003\u8651\u662f\u5426\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5f53\u5361\u745e\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u7ed9\u836f\u65f6\uff0c\u5e94\u9996\u5148\u7ed9\u4e88\u5361\u745e\u5229\u73e0\u5355\u6297\u9759\u8109\u6ef4\u6ce8\uff0c\u95f4\u9694\u81f3\u5c11<span>30<\/span>\u5206\u949f\u540e\u518d\u7ed9\u4e88\u5316\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u662f\uff1a\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u3001<span>AST<\/span>\u5347\u9ad8\u3001<span>ALT<\/span>\u5347\u9ad8\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u3001\u4e4f\u529b\u3001\u86cb\u767d\u5c3f\u3001\u53d1\u70ed\u548c\u767d\u7ec6\u80de\u51cf\u5c11\u75c7\u3002\u5355\u836f\u6cbb\u7597\u6240\u62a5\u544a\u7684\u5927\u591a\u6570\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\u4e3a<span>1<\/span>\u7ea7\u6216<span>2<\/span>\u7ea7\uff0c\u6700\u5e38\u89c1\u7684\uff1e<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\u662f\uff1a\u8d2b\u8840\u3001\u4f4e\u94a0\u8840\u75c7\u3001\u03b3<span>&#8211;<\/span>\u8c37\u6c28\u9170\u8f6c\u79fb\u9176\u5347\u9ad8\u3001<span>AST<\/span>\u5347\u9ad8\u7b49\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u5927\u591a\u6570\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u662f\u53ef\u9006\u7684\uff0c\u4e14\u53ef\u901a\u8fc7\u4e2d\u65ad\u5361\u745e\u5229\u73e0\u5355\u6297\u5e76\u4f7f\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u652f\u6301\u6cbb\u7597\u3002\u5bf9\u4e8e\u5927\u90e8\u5206<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u53ca\u67d0\u4e9b\u7279\u5b9a\u7684<span>2<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u9700\u6682\u505c\u7ed9\u836f\uff0c\u5e76\u7ed9\u4e88<span>1<\/span>\uff5e<span>2mg\/<\/span>\uff08<span>kg<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2022<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">d<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff09\u5f3a\u7684\u677e\u7b49\u6548\u5242\u91cf\u53ca\u5176\u4ed6\u6cbb\u7597\uff0c\u76f4\u81f3\u6539\u5584\u5230\u2264<span>1<\/span>\u7ea7\u3002\u7cd6\u76ae\u8d28\u6fc0\u7d20\u9700\u81f3\u5c11\u4e00\u4e2a\u6708\u7684\u65f6\u95f4\u9010\u6e10\u51cf\u91cf\u76f4\u81f3\u505c\u836f\uff0c\u5feb\u901f\u51cf\u91cf\u53ef\u80fd\u5f15\u8d77\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u7684\u53cd\u590d\u3002\u5982\u679c\u4e0d\u826f\u53cd\u5e94\u5728\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u540e\u7ee7\u7eed\u6076\u5316\u6216\u65e0\u6539\u5584\uff0c\u5219\u5e94\u589e\u52a0\u7cd6\u76ae\u8d28\u6fc0\u7d20\u4ee5\u5916\u7684\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\uff0c\u5927\u591a\u53d1\u751f\u5728\u4f53\u8868\u76ae\u80a4\uff0c\u5c11\u6570\u53ef\u89c1\u4e8e\u53e3\u8154\u9ecf\u819c\u3001\u9f3b\u8154\u9ecf\u819c\u4ee5\u53ca\u773c\u7751\u7ed3\u819c\u3002\u53d1\u751f\u4e8e\u76ae\u80a4\u7684\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\uff0c\u521d\u59cb\u591a\u8868\u73b0\u4e3a\u4f53\u8868\u9c9c\u7ea2\u8272\u70b9\u72b6\u7269\uff0c\u76f4\u5f84\uff1c<span>2mm<\/span>\uff0c\u968f\u7740\u7528\u836f\u6b21\u6570\u589e\u52a0\uff0c\u75c5\u53d8\u8303\u56f4\u53ef\u9010\u6e10\u589e\u5927\uff0c\u591a\u4e3a\u7ed3\u8282\u72b6\uff0c\u4e5f\u6709\u6591\u7247\u72b6\uff0c\u989c\u8272\u9c9c\u7ea2\u6216\u6697\u7ea2\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e<span>4<\/span>\u7ea7\u53ca\u67d0\u4e9b\u7279\u5b9a\u7684<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ca\u4efb\u4f55\u590d\u53d1\u6027<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u672b\u6b21\u7ed9\u836f\u540e<span>12<\/span>\u5468\u5185<span>2<\/span>\uff5e<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u672a\u6539\u5584\u5230<span>0<\/span>\uff5e<span>1<\/span>\u7ea7\uff08\u9664\u5916\u5185\u5206\u6ccc\u75be\u75c5\uff09\uff0c\u4ee5\u53ca\u672b\u6b21\u7ed9\u836f<span>12<\/span>\u5468\u5185\u7cd6\u76ae\u8d28\u6fc0\u7d20\u672a\u80fd\u964d\u81f3\u2264<span>10mg\/d<\/span>\u5f3a\u7684\u677e\u7b49\u6548\u5242\u91cf\uff0c\u5e94\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56e0\u53ef\u80fd\u5e72\u6270\u672c\u54c1\u836f\u6548\u5b66\u6d3b\u6027\uff0c\u5e94\u907f\u514d\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002\u4f46\u662f\u5982\u679c\u4e3a\u4e86\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u540e\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56db\u3001\u7d22\u62c9\u975e\u5c3c<span> Sorafenib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>200mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.6pt;vertical-align:middle;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u5c40\u90e8\u590d\u53d1\u6216\u8f6c\u79fb\u7684\u8fdb\u5c55\u6027\u7684\u653e\u5c04\u6027\u7898\u96be\u6cbb\u6027\u5206\u5316\u578b\u7532\u72b6\u817a\u764c\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7a7a\u8179\u7ed9\u836f\uff0c\u7528\u836f\u524d\u65e0\u9700\u8fdb\u884c\u57fa\u56e0\u68c0\u6d4b\u3002\u82e5\u957f\u671f\u75c5\u60c5\u7a33\u5b9a\uff0c\u4e0d\u9700\u670d\u7528\u6b64\u7c7b\u836f\u7269\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b58\u5728\u53ef\u7591\u7684\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u65f6\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u548c<span>\/<\/span>\u6216\u51cf\u5c11\u7d22\u62c9\u975e\u5c3c\u5242\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u6709\u8179\u6cfb\uff0c\u4e4f\u529b\uff0c\u8131\u53d1\uff0c\u611f\u67d3\uff0c\u624b\u8db3\u76ae\u80a4\u53cd\u5e94\uff0c\u76ae\u75b9\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u7d22\u62c9\u975e\u5c3c\u6216\u672c\u54c1\u4efb\u4e00\u975e\u6d3b\u6027\u6210\u5206\u6709\u4e25\u91cd\u8fc7\u654f\u75c7\u72b6\u7684\u60a3\u8005\u7981\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0e<span>UGT1A1<\/span>\u9014\u5f84\u4ee3\u8c22<span>\/<\/span>\u6e05\u9664\u7684\u836f\u7269\u8054\u5408\u5e94\u7528\u65f6\uff0c\u9700\u8c28\u614e\uff1b\u4e0e\u591a\u897f\u4ed6\u8d5b\u8054\u5408\u5e94\u7528\u65f6\uff0c\u9700\u8c28\u614e\uff1b\u4e0e<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u8054\u5408\u5e94\u7528\u65f6\u53ef\u5bfc\u81f4\u7d22\u62c9\u975e\u5c3c\u7684\u836f\u7269\u6d53\u5ea6\u964d\u4f4e\uff1b\u4e0e\u65b0\u9709\u7d20\u8054\u5408\u5e94\u7528\u53ef\u5bfc\u81f4\u7d22\u62c9\u975e\u5c3c\u7684\u66b4\u9732\u91cf\u4e0b\u964d\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e94\u3001\u4ed1\u4f10\u66ff\u5c3c<span> Lenvatinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>4mg<\/span>\u3001<span>10mg<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fdb\u5c55\u6027\u3001\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u653e\u5c04\u6027\u7898\u96be\u6cbb\u5206\u5316\u578b\u7532\u72b6\u817a\u764c\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u65e5\u5242\u91cf\u4e3a<span>24mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u5e94\u6301\u7eed\u6cbb\u7597\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u63a5\u53d7\u4ed1\u4f10\u66ff\u5c3c\u7684\u60a3\u8005\u4e2d\uff0c\u5e94\u8c28\u614e\u4f7f\u7528\u5df1\u77e5\u5177\u6709\u8f83\u7a84\u6cbb\u7597\u6307\u6570\u7684<span>CYP3A4<\/span>\u5e95\u7269\uff08\u4f8b\u5982\u963f\u53f8\u54aa\u5511\u3001\u7279\u975e\u90a3\u5b9a\u3001\u897f\u6c99\u5fc5\u5229\u3001\u5339\u83ab\u9f50\u7279\u3001\u594e\u5c3c\u4e01\u3001\u82c4\u666e\u5730\u5c14\uff09\u6216\u9ea6\u89d2\u751f\u7269\u78b1\uff08\u9ea6\u89d2\u80fa\u3001\u4e8c\u6c22\u9ea6\u89d2\u80fa\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u8fc7\u7a0b\u9700\u5bc6\u5207\u76d1\u6d4b\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f\u3002\u5728\u7532\u72b6\u817a\u764c\u6cbb\u7597\u4e2d\uff0c\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08\uff1e<span>30%<\/span>\uff09\u4e3a\u9ad8\u8840\u538b\u3001\u75b2\u4e4f\u3001\u8179\u6cfb\u3001\u5173\u8282\u75db<span>\/<\/span>\u808c\u75db\u3001\u98df\u6b32\u4e0b\u964d\u3001\u4f53\u91cd\u51cf\u8f7b\u3001\u6076\u5fc3\u3001\u53e3\u8154\u9ecf\u819c\u708e\u3001\u5934\u75db\u3001\u5455\u5410\u3001\u86cb\u767d\u5c3f\u7b49\u3002\u5fc5\u8981\u65f6\u51cf\u91cf\u3001\u6682\u505c\u7528\u836f\u6216\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e00\u65e6\u51fa\u73b0\u6301\u7eed\u6027\u6216\u4e0d\u53ef\u8010\u53d7\u7684<span>2<\/span>\uff5e<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u5f53\u6682\u505c\u7ed9\u836f\uff0c\u76f4\u81f3\u7f13\u89e3\u81f3<span>0<\/span>\uff5e<span>1<\/span>\u7ea7\u6216\u57fa\u7ebf\u6c34\u5e73\uff0c\u6309\u8c03\u6574\u540e\u51cf\u91cf\u63a8\u8350\uff1a<span>20mg\u219214mg\u219210mg<\/span>\u7684\u65e5\u5242\u91cf\u51cf\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e25\u91cd\u80be\u529f\u80fd\u635f\u4f24\u548c\u809d\u529f\u80fd\u635f\u4f24\u7684\u60a3\u8005\uff0c\u4ed1\u4f10\u66ff\u5c3c\u7684\u5242\u91cf\u5e94\u6539\u4e3a<span>10mg<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4ed1\u4f10\u66ff\u5c3c\u5e94\u5728\u6bcf\u5929\u56fa\u5b9a\u65f6\u95f4\u670d\u7528\uff0c\u7a7a\u8179\u6216\u4e0e\u98df\u7269\u540c\u670d\u5747\u53ef\u3002\u5982\u679c\u60a3\u8005\u9057\u6f0f\u4e00\u6b21\u7528\u836f\u4e14\u65e0\u6cd5\u5728<span>12<\/span>\u5c0f\u65f6\u5185\u670d\u7528\uff0c\u65e0\u9700\u8865\u670d\uff0c\u5e94\u6309\u5e38\u89c4\u7528\u836f\u65f6\u95f4\u8fdb\u884c\u4e0b\u4e00\u6b21\u670d\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u516d\u3001\u5b89\u7f57\u66ff\u5c3c <span>Anlotinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>8mg<\/span>\u3001<span>10mg<\/span>\u3001<span>12mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u5177\u6709\u4e34\u5e8a\u75c7\u72b6\u6216\u660e\u786e\u75be\u75c5\u8fdb\u5c55\u7684\u3001\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u7532\u72b6\u817a\u9ad3\u6837\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>12mg<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\/<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b21<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u65e9\u9910\u524d\u53e3\u670d\u3002\u8fde\u7eed\u670d\u836f<span>2<\/span>\u5468\uff0c\u505c\u836f<span>1<\/span>\u5468\uff0c\u5373<span>3<\/span>\u5468\uff08<span>21<\/span>\u5929\uff09\u4e3a\u4e00\u4e2a\u7597\u7a0b\u3002\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u4e0d\u826f\u53cd\u5e94\u3002\u7528\u836f\u671f\u95f4\u5982\u51fa\u73b0\u6f0f\u670d\uff0c\u786e\u8ba4\u8ddd\u4e0b\u6b21\u7528\u836f\u65f6\u95f4\u77ed\u4e8e<span>12<\/span>\u5c0f\u65f6\uff0c\u5219\u4e0d\u518d\u8865\u670d\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u5e94\u5bc6\u5207\u76d1\u6d4b\u4e0d\u826f\u53cd\u5e94\uff0c\u5e76\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u60c5\u51b5\u8fdb\u884c\u8c03\u6574\u4ee5\u4f7f\u60a3\u8005\u80fd\u591f\u8010\u53d7\u6cbb\u7597\u3002\u672c\u54c1\u6240\u81f4\u7684\u4e0d\u826f\u53cd\u5e94\u53ef\u901a\u8fc7\u5bf9\u75c7\u6cbb\u7597\u3001\u6682\u505c\u7528\u836f\u548c<span>\/<\/span>\u6216\u8c03\u6574\u5242\u91cf\u7b49\u65b9\u5f0f\u5904\u7406\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7a0b\u5ea6\u5206\u7ea7\u7ba1\u7406\uff08\u975e\u51fa\u8840\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\uff09\u3002\u5982\u51fa\u73b0<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\u9700\u6682\u505c\u7528\u836f\uff0c\u76f4\u81f3\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u81f3\uff1c<span>2<\/span>\u7ea7\u540e\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\uff08<span>12mg<\/span>\u2192<span>10mg<\/span>\u2192<span>8mg<\/span>\uff09\u7ee7\u7eed\u7528\u836f\uff0c\u82e5\u4e0d\u826f\u53cd\u5e94\u6301\u7eed\u8d85\u8fc7<span>2<\/span>\u5468\u5219\u6c38\u4e45\u505c\u836f\u3002\u5982\u51fa\u73b0<span>4<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\u5e94\u8003\u8651\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c\u7684\u91cd\u8981\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\uff1a\u51fa\u8840\u3001\u9ad8\u8840\u538b\u3001\u86cb\u767d\u5c3f\u3001\u624b\u8db3\u7efc\u5408\u5f81\u3001\u8179\u6cfb\u3001\u5fc3\u808c\u7f3a\u8840\u7b49\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u6cbb\u7597\u671f\u95f4\u5e94\u5bf9\u60a3\u8005\u7684\u51fa\u8840\u76f8\u5173\u4f53\u5f81\u548c\u75c7\u72b6\u8fdb\u884c\u76d1\u6d4b\u3002\u5177\u6709\u51fa\u8840\u98ce\u9669\u3001\u51dd\u8840\u529f\u80fd\u5f02\u5e38\u7684\u60a3\u8005\u5e94\u614e\u7528\uff0c\u670d\u7528\u671f\u95f4\u5e94\u4e25\u5bc6\u76d1\u6d4b\u8840\u5c0f\u677f\u3001\u51dd\u8840\u9176\u539f\u65f6\u95f4\u3002\u51fa\u73b0<span>2<\/span>\u7ea7\u51fa\u8840\u4e8b\u4ef6\u7684\u60a3\u8005\u5e94\u6682\u505c\u5b89\u7f57\u66ff\u5c3c\u6cbb\u7597\uff0c\u5982\u4e24\u5468\u5185\u6062\u590d\u81f3\uff1c<span>2<\/span>\u7ea7\uff0c\u5219\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u7ee7\u7eed\u7528\u836f\u3002\u5982\u518d\u6b21\u51fa\u8840\uff0c\u5e94\u6c38\u4e45\u505c\u836f\u3002\u4e00\u65e6\u51fa\u73b0<span>3<\/span>\u7ea7\u6216\u4ee5\u4e0a\u7684\u51fa\u8840\u4e8b\u4ef6\uff0c\u5219\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56e0\u4e34\u5e8a\u8bd5\u9a8c\u6392\u9664\u4e86\u5b58\u5728\u51fa\u8840\u4f53\u8d28\u8ff9\u8c61\u6216\u75c5\u53f2\u3001\u7528\u836f\u524d<span>4<\/span>\u5468\u5185\u51fa\u73b0\u2265<span>3<\/span>\u7ea7\u7684\u4efb\u4f55\u51fa\u8840\u4e8b\u4ef6\u3001\u5b58\u5728\u672a\u6108\u5408\u521b\u53e3\u3001\u6e83\u75a1\u6216\u9aa8\u6298\uff0c\u56e0\u6b64\u5177\u6709\u4ee5\u4e0a\u98ce\u9669\u7684\u60a3\u8005\u5e94\u5728\u533b\u5e08\u6307\u5bfc\u4e0b\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e03\u3001\u7eb3\u6b66\u5229\u5c24\u5355\u6297<span> Nivolumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">40mg<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08<span>4ml<\/span>\uff09<span>\/<\/span>\u74f6\u3001<span>100mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u9002\u7528\u4e8e\u6cbb\u7597\u63a5\u53d7\u542b\u94c2\u7c7b\u65b9\u6848\u6cbb\u7597\u671f\u95f4\u6216\u4e4b\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u4e14\u80bf\u7624<span>PD-L1<\/span>\u8868\u8fbe\u9633\u6027\uff08\u5b9a\u4e49\u4e3a\u8868\u8fbe<span>PD-L1<\/span>\u7684\u80bf\u7624\u7ec6\u80de\u2265<span>1%<\/span>\uff09\u7684\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u63a5\u53d7\u542b\u94c2\u7c7b\u65b9\u6848\u6cbb\u7597\u671f\u95f4\u6216\u4e4b\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u4e14\u80bf\u7624<span>PD-L1<\/span>\u8868\u8fbe\u9633\u6027\uff08\u5b9a\u4e49\u4e3a\u8868\u8fbe<span>PD-L1<\/span>\u7684\u80bf\u7624\u7ec6\u80de\u2265<span>1%<\/span>\uff09\u7684\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u63a8\u8350\u7ed9\u836f\u65b9\u6848\u4e3a<span>3mg\/kg<\/span>\u6216<span>240mg<\/span>\u56fa\u5b9a\u5242\u91cf\uff0c\u9759\u8109\u6ce8\u5c04\uff0c\u6301\u7eed<span>30<\/span>\u5206\u949f\uff0c\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4ea7\u751f\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u53ea\u8981\u89c2\u5bdf\u5230\u4e34\u5e8a\u83b7\u76ca\uff0c\u5e94\u7ee7\u7eed\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u60a3\u8005\u4e0d\u80fd\u8010\u53d7\u3002\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u505c\u836f\uff0c\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u53ef\u5f15\u8d77\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u6301\u7eed\u8fdb\u884c\u60a3\u8005\u76d1\u6d4b\uff08\u81f3\u5c11\u81f3\u672b\u6b21\u7ed9\u836f\u540e<span>5<\/span>\u4e2a\u6708\uff09\uff0c\u56e0\u4e3a\u4e0d\u826f\u53cd\u5e94\u53ef\u80fd\u5728\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u671f\u95f4\u6216\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u505c\u6b62\u540e\u7684\u4efb\u4f55\u65f6\u95f4\u53d1\u751f\u3002\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u5e94\u6682\u505c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u5e76\u7ed9\u4e88\u7cd6\u76ae\u8d28\u6fc0\u7d20\u3002\u82e5\u4f7f\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u514d\u75ab\u6291\u5236\u7597\u6cd5\u6cbb\u7597\u4e0d\u826f\u53cd\u5e94\uff0c\u75c7\u72b6\u6539\u5584\u540e\uff0c\u9700\u81f3\u5c11<span>1<\/span>\u4e2a\u6708\u7684\u65f6\u95f4\u9010\u6e10\u51cf\u91cf\u81f3\u505c\u836f\u3002\u5feb\u901f\u51cf\u91cf\u53ef\u80fd\u5f15\u8d77\u4e0d\u826f\u53cd\u5e94\u6076\u5316\u6216\u590d\u53d1\u3002\u5982\u679c\u867d\u4f7f\u7528\u4e86\u7cd6\u76ae\u8d28\u6fc0\u7d20\u4f46\u4ecd\u6076\u5316\u6216\u65e0\u6539\u5584\uff0c\u5219\u5e94\u589e\u52a0\u975e\u7cd6\u76ae\u8d28\u6fc0\u7d20\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u3002\u5728\u60a3\u8005\u63a5\u53d7\u514d\u75ab\u6291\u5236\u5242\u91cf\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u671f\u95f4\uff0c\u4e0d\u53ef\u91cd\u65b0\u4f7f\u7528\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u3002\u5728\u63a5\u53d7\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u5e94\u4f7f\u7528\u9884\u9632\u6027\u6297\u751f\u7d20\u9884\u9632\u673a\u4f1a\u6027\u611f\u67d3\u3002\u82e5\u51fa\u73b0\u4efb\u4f55\u91cd\u5ea6\u3001\u590d\u53d1\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u4ee5\u53ca\u4efb\u4f55\u5371\u53ca\u751f\u547d\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5fc5\u987b\u6c38\u4e45\u505c\u6b62\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51fa\u73b0\u8f7b\u4e2d\u5ea6\u8f93\u6db2\u53cd\u5e94\u7684\u60a3\u8005\u5728\u63a5\u53d7\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u65f6\u5e94\u5bc6\u5207\u76d1\u6d4b\uff0c\u5e76\u4f9d\u7167\u8f93\u6db2\u53cd\u5e94\u7684\u6cbb\u7597\u6307\u5357\u9884\u9632\u7528\u836f\u3002\u5982\u679c\u51fa\u73b0\u91cd\u5ea6\u6216\u5371\u53ca\u751f\u547d\u7684\u8f93\u6db2\u53cd\u5e94\uff0c\u5fc5\u987b\u505c\u6b62\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\uff0c\u7ed9\u4e88\u9002\u5f53\u7684\u836f\u7269\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6709\u53ef\u80fd\u4f1a\u7ecf\u6bcd\u4f53\u4f20\u8f93\u81f3\u53d1\u80b2\u4e2d\u7684\u80ce\u513f\u3002\u4e0d\u5efa\u8bae\u5728\u598a\u5a20\u671f\u95f4\u3001\u5728\u4e0d\u91c7\u7528\u6709\u6548\u907f\u5b55\u63aa\u65bd\u7684\u80b2\u9f84\u671f\u5973\u6027\u4e2d\u4f7f\u7528\u7eb3\u6b66\u5229\u5c24\u5355\u6297\uff0c\u9664\u975e\u4e34\u5e8a\u83b7\u76ca\u5927\u4e8e\u6f5c\u5728\u98ce\u9669\u3002\u5e94\u5728\u6700\u540e\u4e00\u6b21\u5e94\u7528\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u540e\u81f3\u5c11<span>5<\/span>\u4e2a\u6708\u5185\u91c7\u7528\u6709\u6548\u907f\u5b55\u63aa\u65bd\u3002\u65e0\u6cd5\u6392\u9664\u4f1a\u5bf9\u65b0\u751f\u513f<span>\/<\/span>\u5a74\u513f\u9020\u6210\u98ce\u9669\uff0c\u5728\u8003\u8651\u6bcd\u4e73\u5582\u517b\u5bf9\u5b69\u5b50\u7684\u76ca\u5904\u4ee5\u53ca\u6cbb\u7597\u5bf9\u5987\u5973\u7684\u76ca\u5904\u540e\uff0c\u5fc5\u987b\u505a\u51fa\u662f\u505c\u6b62\u6bcd\u4e73\u5582\u517b\u8fd8\u662f\u505c\u6b62\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u7684\u51b3\u5b9a\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c1a\u672a\u786e\u7acb\u672c\u54c1\u5728<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u5728\u8001\u5e74\u4eba\u7fa4\u4e2d\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u6570\u636e\u6709\u9650\u3002\u8f7b\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u6ca1\u6709\u5bf9\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u8fdb\u884c\u672c\u54c1\u7684\u76f8\u5173\u7814\u7a76\uff0c\u91cd\u5ea6\uff08\u603b\u80c6\u7ea2\u7d20\uff1e<span>3<\/span>\u500d<span>ULN<\/span>\uff09\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5fc5\u987b\u614e\u7528\u672c\u54c1\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u907f\u514d\u5728\u57fa\u7ebf\u5f00\u59cb\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u524d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u516b\u3001\u897f\u59a5\u6614\u5355\u6297 <span>Cetuximab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>20ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u7528\u4e8e\u6cbb\u7597\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\uff1a\u4e0e\u94c2\u7c7b\u548c\u6c1f\u5c3f\u5627\u5576\u5316\u7597\u8054\u5408\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u590d\u53d1\u548c<span>\/<\/span>\u6216\u8f6c\u79fb\u6027\u75be\u75c5\u3002<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5fc5\u987b\u5728\u6709\u6297\u80bf\u7624\u836f\u7269\u4f7f\u7528\u7ecf\u9a8c\u7684\u533b\u5e08\u6307\u5bfc\u4e0b\u4f7f\u7528\u3002\u5728\u7528\u836f\u8fc7\u7a0b\u4e2d\u53ca\u7528\u836f\u7ed3\u675f\u540e<span>1<\/span>\u5c0f\u65f6\u5185\uff0c\u9700\u5bc6\u5207\u76d1\u6d4b\u60a3\u8005\u7684\u72b6\u51b5\uff0c\u5e76\u5fc5\u987b\u914d\u5907\u590d\u82cf\u8bbe\u5907\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5e94\u50a8\u5b58\u5728<span>2<\/span>\uff5e<span>8<\/span>\u2103\uff0c\u5f00\u542f\u540e\u5e94\u7acb\u5373\u4f7f\u7528\uff0c\u7981\u6b62\u51b7\u51bb\u3002\u8bf7\u7f6e\u4e8e\u513f\u7ae5\u4e0d\u53ef\u89e6\u53ca\u5904\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u9996\u6b21\u6ef4\u6ce8\u672c\u54c1\u4e4b\u524d\u81f3\u5c11<span>1<\/span>\u5c0f\u65f6\uff0c\u60a3\u8005\u5fc5\u987b\u63a5\u53d7\u6297\u7ec4\u80fa\u836f\u7269\u548c<span>\/<\/span>\u6216\u7cd6\u76ae\u8d28\u6fc0\u7d20\u836f\u7269\u7684\u9884\u9632\u7528\u836f\u3002\u5efa\u8bae\u5728\u540e\u7eed\u6cbb\u7597\u4e2d\uff0c\u6bcf\u6b21\u4f7f\u7528\u672c\u54c1\u524d\u90fd\u7ed9\u4e88\u60a3\u8005\u4e0a\u8ff0\u9884\u9632\u7528\u836f\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6240\u6709\u9002\u5e94\u8bc1\uff0c\u672c\u54c1\u6bcf\u5468\u7ed9\u836f\u4e00\u6b21\u3002\u521d\u59cb\u5242\u91cf\u6309\u4f53\u8868\u9762\u79ef\u4e3a<span>400mg\/<\/span>\u33a1\uff0c\u4e4b\u540e\u6bcf\u5468\u7ed9\u836f\u5242\u91cf\u6309\u4f53\u8868\u9762\u79ef\u4e3a<span>250mg\/<\/span>\u33a1\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u4e0e\u94c2\u7c7b\u5316\u5408\u7269\u4e3a\u57fa\u7840\u7684\u5316\u7597\u836f\u7269\u8054\u5408\u5e94\u7528\u4e8e\u590d\u53d1\u548c<span>\/<\/span>\u6216\u8f6c\u79fb\u6027\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u7684\u6cbb\u7597\uff0c\u968f\u540e\u7ee7\u7eed\u4f7f\u7528\u672c\u54c1\u8fdb\u884c\u7ef4\u6301\u6cbb\u7597\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u3002\u5316\u7597\u836f\u7269\u7684\u4f7f\u7528\u5fc5\u987b\u5728\u672c\u54c1\u6ef4\u6ce8\u7ed3\u675f<span>1<\/span>\u5c0f\u65f6\u4e4b\u540e\u5f00\u59cb\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e0\u8bba<span>EGFR<\/span>\u7684\u8868\u8fbe\u72b6\u51b5\u5982\u4f55\uff0c\u6240\u6709\u6709\u6548\u6027\u7ec8\u70b9\u5747\u8bc1\u5b9e\u6709\u4e34\u5e8a\u83b7\u76ca\u3002\u5c1a\u65e0\u8bc1\u636e\u8bc1\u5b9e<span>EGFR<\/span>\u8868\u8fbe\u7b49\u76f8\u5173\u6807\u5fd7\u7269\u68c0\u6d4b\u80fd\u9884\u6d4b\u672c\u54c1\u5728\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u4e2d\u7684\u7597\u6548\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5168\u7403\u7814\u7a76\uff08<span>EXTREME<\/span>\uff09\u662f\u4e00\u9879\u7eb3\u5165<span>442<\/span>\u4f8b\u5c40\u90e8\u590d\u53d1\u548c<span>\/<\/span>\u6216\u8f6c\u79fb\u6027\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u7684\u591a\u4e2d\u5fc3\u2162\u671f\u7814\u7a76\u3002\u4e2d\u56fd\u7814\u7a76\uff08<span>CHANGE2<\/span>\uff09\u662f\u4e00\u7ebf\u6cbb\u7597\u4e2d\u56fd\u5934\u9888\u90e8\u590d\u53d1\u6027\u548c<span>\/<\/span>\u6216\u8f6c\u79fb\u6027\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u2162\u671f\u7814\u7a76\u3002<span>CHANGE2<\/span>\u7684\u6709\u6548\u6027\u7ed3\u679c\u4e0e<span>EXTREME<\/span>\u7ed3\u679c\u4e00\u81f4\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u53ef\u4f7f\u7528\u8f93\u6db2\u6cf5\u3001\u91cd\u529b\u6ef4\u6ce8\u6216\u6ce8\u5c04\u6cf5\u8fdb\u884c\u9759\u8109\u7ed9\u836f\u3002\u9996\u6b21\u7ed9\u836f\u5e94\u7f13\u6162\uff0c\u6ef4\u6ce8\u901f\u5ea6\u4e0d\u5f97\u8d85\u8fc7<span>5mg\/min<\/span>\u3002\u5efa\u8bae\u6ef4\u6ce8\u65f6\u95f4\u4e3a<span>120<\/span>\u5206\u949f\uff0c\u968f\u540e\u6bcf\u5468\u7ed9\u836f\u7684\u6ef4\u6ce8\u65f6\u95f4\u4e3a<span>60<\/span>\u5206\u949f\uff0c\u6ef4\u6ce8\u901f\u5ea6\u4e0d\u5f97\u8d85\u8fc7<span>10mg\/min<\/span>\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u7684\u4e3b\u8981\u4e0d\u826f\u53cd\u5e94\u6709\u76ae\u80a4\u53cd\u5e94\uff0c\u53d1\u751f\u7387\u7ea6<span>80%<\/span>\u4ee5\u4e0a\uff0c\u7ea6\u8d85\u8fc7<span>10%<\/span>\u7684\u60a3\u8005\u53d1\u751f\u4f4e\u9541\u8840\u75c7\uff0c<span>10%<\/span>\u4ee5\u4e0a\u60a3\u8005\u53d1\u751f\u8f7b\u4e2d\u5ea6\u7684\u8f93\u6db2\u53cd\u5e94\uff0c<span>1%<\/span>\u4ee5\u4e0a\u7684\u60a3\u8005\u4f1a\u53d1\u751f\u91cd\u5ea6\u8f93\u6db2\u53cd\u5e94\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c1a\u65e0\u513f\u7ae5\u60a3\u8005\u7684\u7528\u836f\u7ecf\u9a8c\uff0c\u672a\u786e\u7acb\u672c\u54c1\u5728\u672a\u6ee1<span>18<\/span>\u5c81\u60a3\u8005\u4e2d\u7684\u6709\u6548\u6027\u3002\u8001\u5e74\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002<span>75<\/span>\u5c81\u4ee5\u4e0a\u60a3\u8005\u7684\u7528\u836f\u7ecf\u9a8c\u6709\u9650\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u6027\u8d28\u4e0d\u4f1a\u53d7\u79cd\u65cf\u3001\u5e74\u9f84\u3001\u6027\u522b\u3001\u809d\u80be\u72b6\u51b5\u7684\u5f71\u54cd\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u4ec5\u5bf9\u809d\u80be\u529f\u80fd\u6b63\u5e38\u7684\u60a3\u8005\u8fdb\u884c\u8fc7\u672c\u54c1\u7684\u76f8\u5173\u7814\u7a76\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u4e5d\u3001\u5e15\u535a\u5229\u73e0\u5355\u6297 <span>Pembrolizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>4ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u901a\u8fc7\u5145\u5206\u9a8c\u8bc1\u7684\u68c0\u6d4b\u8bc4\u4f30\u80bf\u7624\u8868\u8fbe<span>PD-L1<\/span>\uff08\u7efc\u5408\u9633\u6027\u8bc4\u5206\u2265<span>20<\/span>\uff09\u7684\u8f6c\u79fb\u6027\u6216\u4e0d\u53ef\u5207\u9664\u7684\u590d\u53d1\u6027\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u590d\u53d1<span>\/<\/span>\u8f6c\u79fb\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u4e00\u7ebf\u9002\u5e94\u8bc1\u662f\u57fa\u4e8e\u5168\u7403\u2162\u671f<span>KEYNOTE-048<\/span>\u4e34\u5e8a\u7814\u7a76\u7684\u7ed3\u679c\u3002\u5e15\u535a\u5229\u73e0\u5355\u6297\u901a\u8fc7\u9759\u8109\u6ce8\u5c04\u7ed9\u836f<span>200mg<\/span>\u56fa\u5b9a\u5242\u91cf\uff0c\u9759\u8109\u8f93\u6ce8<span>30<\/span>\u5206\u949f\u4ee5\u4e0a\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u5e15\u535a\u5229\u73e0\u5355\u6297\u5355\u836f\u65b9\u6848\u5df2\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u548c<span>FDA<\/span>\u6279\u51c6\uff0c\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u65b9\u6848\u5df2\u83b7\u5f97\u7f8e\u56fd<span>FDA<\/span>\u6279\u51c6\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u4f46\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u505c\u836f\uff0c\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u4e3b\u8981\u4e0d\u826f\u53cd\u5e94\u662f\u75b2\u52b3\u3001\u7619\u75d2\u3001\u8179\u6cfb\u548c\u76ae\u75b9\u3002\u63a5\u53d7\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u53ef\u53d1\u751f\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u4e25\u91cd\u548c\u81f4\u6b7b\u75c5\u4f8b\u3002\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u53ef\u540c\u65f6\u53d1\u751f\u5728\u591a\u4e2a\u5668\u5b98\u7cfb\u7edf\uff0c\u9700\u8981\u5bf9\u4e8e\u7591\u4f3c\u75c5\u4f8b\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u5b9a\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u5e94\u6682\u65f6\u505c\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\uff0c\u5e76\u5e94\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u3002\u5f53\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u6539\u5584\u81f3\u2264<span>1<\/span>\u7ea7\u65f6\uff0c\u9700\u81f3\u5c11\u4e00\u4e2a\u6708\u7684\u65f6\u95f4\u9010\u6b65\u51cf\u5c11\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7684\u7528\u91cf\u76f4\u81f3\u505c\u836f\u3002\u5018\u82e5\u53d1\u751f\u7cd6\u76ae\u8d28\u6fc0\u7d20\u65e0\u6cd5\u63a7\u5236\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u65f6\uff0c\u53ef\u4ee5\u8003\u8651\u4f7f\u7528\u5176\u4ed6\u5168\u8eab\u6027\u514d\u75ab\u6291\u5236\u5242\u3002\u5982\u679c\u4e0d\u826f\u53cd\u5e94\u4fdd\u6301\u5728\u2264<span>1<\/span>\u7ea7\uff0c\u4e14\u7cd6\u76ae\u8d28\u6fc0\u7d20\u5242\u91cf\u5df2\u964d\u81f3\u2264<span>10mg<\/span>\u6cfc\u5c3c\u677e\u6216\u7b49\u6548\u5242\u91cf\uff0c\u53ef\u5728\u6700\u540e\u4e00\u6b21\u4f7f\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ed9\u836f\u540e<span>12<\/span>\u5468\u5185\u91cd\u65b0\u5f00\u59cb\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u3002\u5bf9\u4e8e\u4efb\u4f55\u590d\u53d1\u6027<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u4ee5\u53ca\u4efb\u4f55<span>4<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u6c38\u4e45\u505c\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u51fa\u73b0\u8f7b\u4e2d\u5ea6\u8f93\u6db2\u53cd\u5e94\u7684\u60a3\u8005\u5728\u5bc6\u5207\u76d1\u6d4b\u4e0b\u53ef\u7ee7\u7eed\u63a5\u53d7\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\uff0c\u53ef\u8003\u8651\u7528\u89e3\u70ed\u9547\u75db\u7c7b\u6297\u708e\u836f\u548c\u6297\u7ec4\u80fa\u836f\u9884\u9632\u3002\u5bf9\u4e8e\u91cd\u5ea6\u7684\u8f93\u6db2\u53cd\u5e94\uff0c\u5fc5\u987b\u505c\u6b62\u8f93\u6db2\u5e76\u6c38\u4e45\u505c\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5b55\u5987\u5728\u598a\u5a20\u671f\u4f7f\u7528\u53ef\u80fd\u4f1a\u5bf9\u80ce\u513f\u9020\u6210\u4f24\u5bb3\uff0c\u9664\u975e\u5b55\u5987\u7684\u4e34\u5e8a\u75be\u75c5\u9700\u8981\uff0c\u598a\u5a20\u671f\u4e0d\u5f97\u7528\u836f\u3002\u5efa\u8bae\u80b2\u9f84\u5973\u6027\u5728\u7528\u836f\u671f\u95f4\u91c7\u7528\u9ad8\u6548\u907f\u5b55\u65b9\u6cd5\uff0c\u5e76\u5728\u6700\u540e\u4e00\u6b21\u7528\u836f\u540e\u56db\u4e2a\u6708\u5185\u6301\u7eed\u907f\u5b55\u3002\u4e0d\u80fd\u6392\u9664\u672c\u54c1\u5bf9\u65b0\u751f\u513f\u7684\u98ce\u9669\uff0c\u5e94\u6743\u8861\u54fa\u4e73\u5bf9\u80ce\u513f\u7684\u83b7\u76ca\u4ee5\u53ca\u672c\u54c1\u6cbb\u7597\u5bf9\u5973\u6027\u60a3\u8005\u7684\u83b7\u76ca\u6765\u51b3\u7b56\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5c1a\u672a\u786e\u5b9a<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u4f7f\u7528\u672c\u54c1\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6027\uff0c\u5728\u8001\u5e74\u4eba\u7fa4\u4e2d\u4e0d\u9700\u8981\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u5c1a\u672a\u5728\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u8fdb\u884c\u672c\u54c1\u7684\u76f8\u5173\u7814\u7a76\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5728\u4f7f\u7528\u8be5\u836f\u524d\u907f\u514d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p><b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><br \/>\n<\/span><\/b> <\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u751f\u6b96\u7cfb\u7edf\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e00\u3001\u5965\u62c9\u5e15\u5229<span> Olaparib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>100mg<\/span>\u3001<span>150mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u643a\u5e26\u80da\u7cfb\u6216\u4f53\u7ec6\u80de<span>BRCA<\/span>\u7a81\u53d8\u665a\u671f\u4e0a\u76ae\u6027\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u764c\u521d\u6cbb\u6210\u4eba\u60a3\u8005\u5728\u4e00\u7ebf\u542b\u94c2\u5316\u7597\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u6216\u90e8\u5206\u7f13\u89e3\u540e\u7684\u7ef4\u6301\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u94c2\u654f\u611f\u7684\u590d\u53d1\u6027\u4e0a\u76ae\u6027\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u764c\u6210\u4eba\u60a3\u8005\u5728\u542b\u94c2\u5316\u7597\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u6216\u90e8\u5206\u7f13\u89e3\u540e\u7684\u7ef4\u6301\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u5e76\u540c\u6e90\u91cd\u7ec4\u4fee\u590d\u7f3a\u9677\u9633\u6027\u7684\u665a\u671f\u4e0a\u76ae\u6027\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u764c\u521d\u6cbb\u6210\u4eba\u60a3\u8005\u5728\u4e00\u7ebf\u542b\u94c2\u5316\u7597\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u6216\u90e8\u5206\u7f13\u89e3\u540e\u4e0e\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408\u8fdb\u884c\u7684\u7ef4\u6301\u6cbb\u7597\uff08\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5c1a\u672a\u6279\u51c6\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u643a\u5e26\u80da\u7cfb<span>BRCA<\/span>\u7a81\u53d8\u3001\u7ecf\u8fc7\u4e09\u7ebf\u6216\u66f4\u591a\u7ebf\u5316\u7597\u7684\u665a\u671f\u5375\u5de2\u764c\u6210\u4eba\u60a3\u8005\uff08\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5c1a\u672a\u6279\u51c6\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5965\u62c9\u5e15\u5229\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u65b9\u6848\u7528\u4e8e\u4e00\u7ebf\u7ef4\u6301\u6cbb\u7597\u7684\u9002\u5e94\u8bc1\u57fa\u4e8e\u2162\u671f<span>PAOLA-1<\/span>\u7814\u7a76\u7ed3\u679c\uff1b\u5965\u62c9\u5e15\u5229\u7528\u4e8e\u540e\u7ebf\u5375\u5de2\u764c\u6cbb\u7597\u7684\u9002\u5e94\u8bc1\u57fa\u4e8e\u2162\u671f<span>SOLO-3<\/span>\u7814\u7a76\u7ed3\u679c\u3002\u4ee5\u4e0a\u9002\u5e94\u8bc1\u5df2\u83b7\u5f97\u7f8e\u56fd<span>FDA<\/span>\u6279\u51c6\uff0c\u4f46\u76ee\u524d\u5c1a\u672a\u5f97\u5230\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u7684\u83b7\u6279\uff0c\u53ef\u5728\u4e0e\u60a3\u8005\u5145\u5206\u6c9f\u901a\u7684\u60c5\u51b5\u4e0b\u8003\u8651\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a\u6b63\u5e38\u6210\u4eba<span>300mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u5373\u6bcf\u5929\u603b\u5242\u91cf\u4e3a<span>600mg<\/span>\u3002\u5e94\u5728\u542b\u94c2\u5316\u7597\u7ed3\u675f\u540e\u7684<span>8<\/span>\u5468\u5185\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u3002\u63a8\u8350\u7597\u7a0b\uff1a<span>BRCA<\/span>\u7a81\u53d8\u7684\u665a\u671f\u5375\u5de2\u764c\u7684\u4e00\u7ebf\u7ef4\u6301\u6cbb\u7597\u53ef\u6301\u7eed\u6cbb\u7597\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u53d1\u751f\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u53cd\u5e94\uff0c\u6216\u5b8c\u6210<span>2<\/span>\u5e74\u6cbb\u7597\u3002<span>2<\/span>\u5e74\u6cbb\u7597\u540e\uff0c\u5b8c\u5168\u7f13\u89e3\uff08\u5f71\u50cf\u5b66\u65e0\u80bf\u7624\u8bc1\u636e\uff09\u7684\u60a3\u8005\u5e94\u505c\u6b62\u6cbb\u7597\uff0c\u5f71\u50cf\u5b66\u663e\u793a\u6709\u80bf\u7624\u4e14\u4e34\u5e8a\u533b\u751f\u8ba4\u4e3a\u60a3\u8005\u80fd\u4ece\u6301\u7eed\u6cbb\u7597\u4e2d\u8fdb\u4e00\u6b65\u83b7\u76ca\u7684\u60c5\u51b5\u4e0b\u53ef\u4ee5\u7ee7\u7eed\u6cbb\u7597\u8d85\u8fc7<span>2<\/span>\u5e74\u3002\u94c2\u654f\u611f\u7684\u590d\u53d1\u6027\u5375\u5de2\u764c\u7684\u7ef4\u6301\u6cbb\u7597\u53ef\u6301\u7eed\u6cbb\u7597\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u53d1\u751f\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u6574\u7247\u541e\u670d\uff0c\u4e0d\u5e94\u5480\u56bc\u3001\u538b\u788e\u3001\u6eb6\u89e3\u6216\u63b0\u65ad\u836f\u7247\u3002\u5728\u8fdb\u9910\u6216\u7a7a\u8179\u65f6\u5747\u53ef\u670d\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u60a3\u8005\u6f0f\u670d\u4e00\u5242\u836f\u7269\uff0c\u65e0\u9700\u8865\u670d\uff0c\u4ecd\u6309\u8ba1\u5212\u65f6\u95f4\u6b63\u5e38\u670d\u7528\u4e0b\u4e00\u5242\u91cf\uff0c\u5e76\u4e0d\u5f71\u54cd\u6574\u4f53\u7597\u6548\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u60a3\u8005\u5e94\u5728\u65e2\u5f80\u6297\u80bf\u7624\u6cbb\u7597\u5f15\u8d77\u7684\u8840\u6db2\u5b66\u6bd2\u6027\u6062\u590d\u4e4b\u540e\uff08\u8840\u7ea2\u86cb\u767d\u3001\u8840\u5c0f\u677f\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u6c34\u5e73\u5e94\u6062\u590d\u81f3\u2264<span>CTCAE 1<\/span>\u7ea7\uff09\uff0c\u624d\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u3002\u5728\u6cbb\u7597\u6700\u521d\u7684<span>12<\/span>\u4e2a\u6708\u5185\uff0c\u63a8\u8350\u5728\u57fa\u7ebf\u8fdb\u884c\u5168\u8840\u7ec6\u80de\u68c0\u6d4b\uff0c\u968f\u540e\u6bcf\u6708\u76d1\u6d4b\u4e00\u6b21\uff0c\u4e4b\u540e\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u671f\u95f4\u51fa\u73b0\u7684\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u53c2\u6570\u53d8\u5316\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5e38\u89c1\u7684\u5404\u7c7b\u4e0d\u826f\u53cd\u5e94\u4e3a\u8d2b\u8840\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u4e0b\u964d\u3001\u6076\u5fc3\u3001\u5455\u5410\u3001\u8179\u6cfb\u3001\u4e0a\u547c\u5438\u9053\u611f\u67d3\u3001\u75b2\u4e4f\u3001\u98df\u6b32\u4e0b\u964d\u3001\u5173\u8282\u75db\u3001\u808c\u75db\u3001\u5473\u89c9\u969c\u788d\u548c\u5934\u75db\u7b49\uff0c\u5176\u4e2d\u53d1\u751f\u7387\u6700\u9ad8\u7684\u4e0d\u826f\u53cd\u5e94\u4f9d\u6b21\u4e3a\u6076\u5fc3\u3001\u75b2\u4e4f\u548c\u8d2b\u8840\uff0c\u5927\u591a\u4e3a<span>1<\/span>\uff5e<span>2<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u7684\u8d2b\u8840\u53d1\u751f\u7387\u7ea6\u4e3a<span>20%<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>4<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\u53ef\u901a\u8fc7\u5242\u91cf\u4e2d\u65ad\u6765\u7ba1\u7406\u3002\u5f85\u75c7\u72b6\u6062\u590d\u81f3\u2264<span>1<\/span>\u7ea7\u65f6\uff0c\u91cd\u65b0\u5f00\u59cb\u539f\u5242\u91cf\u6216\u51cf\u91cf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u9700\u8981\u51cf\u91cf\uff0c\u63a8\u8350\u5242\u91cf\u51cf\u81f3<span>250mg\/<\/span>\u6b21\uff08<span>1<\/span>\u7247<span>150mg<\/span>\u7247\u5242\uff0c<span>1<\/span>\u7247<span>100mg<\/span>\u7247\u5242\uff09\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u5373\u6bcf\u5929\u603b\u5242\u91cf\u4e3a<span>500mg<\/span>\u3002\u5982\u679c\u9700\u8981\u8fdb\u4e00\u6b65\u51cf\u91cf\uff0c\u5219\u63a8\u8350\u5242\u91cf\u51cf\u81f3<span>200mg\/<\/span>\u6b21\uff08<span>2<\/span>\u7247<span>100mg<\/span>\u7247\u5242\uff09\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u5373\u6bcf\u5929\u603b\u5242\u91cf\u4e3a<span>400mg<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u63a8\u8350\u672c\u54c1\u4e0e\u5f3a\u6548\u6216\u4e2d\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\u5408\u5e76\u4f7f\u7528\uff0c\u5982\u679c\u5fc5\u987b\u5408\u5e76\u4f7f\u7528\u5f3a\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\uff0c\u63a8\u8350\u5c06\u672c\u54c1\u5242\u91cf\u51cf\u81f3<span>100mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u5982\u679c\u5fc5\u987b\u5408\u5e76\u4f7f\u7528\u4e2d\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\uff0c\u63a8\u8350\u5c06\u672c\u54c1\u5242\u91cf\u51cf\u81f3<span>150mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u5c3c\u62c9\u5e15\u5229<span> Niraparib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>100mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u9002\u7528\u4e8e\u665a\u671f\u4e0a\u76ae\u6027\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u764c\u6210\u4eba\u60a3\u8005\u5bf9\u4e00\u7ebf\u542b\u94c2\u5316\u7597\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u6216\u90e8\u5206\u7f13\u89e3\u540e\u7684\u7ef4\u6301\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u9002\u7528\u4e8e\u94c2\u654f\u611f\u7684\u590d\u53d1\u6027\u4e0a\u76ae\u6027\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u764c\u6210\u4eba\u60a3\u8005\u5728\u542b\u94c2\u5316\u7597\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u6216\u90e8\u5206\u7f13\u89e3\u540e\u7684\u7ef4\u6301\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4ecb\u7ecd\uff1a\uff08<span>1<\/span>\uff09\u5375\u5de2\u764c\u4e00\u7ebf\u7ef4\u6301\u6cbb\u7597\uff1a\u5bf9\u4e8e\u4f53\u91cd\uff1c<span>77kg<\/span>\u6216\u8005\u57fa\u7ebf\u8840\u5c0f\u677f\u8ba1\u6570\uff1c<span>150<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u7684\u60a3\u8005\uff0c\u672c\u54c1\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u5929\u4e00\u6b21\u53e3\u670d<span>200mg<\/span>\uff1b\u5bf9\u4e8e\u4f53\u91cd\u2265<span>77kg<\/span>\u4e14\u57fa\u7ebf\u8840\u5c0f\u677f\u8ba1\u6570\u2265<span>150<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u7684\u60a3\u8005\uff0c\u672c\u54c1\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u5929\u4e00\u6b21\u53e3\u670d<span>300mg<\/span>\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u4e0d\u826f\u53cd\u5e94\u3002\u60a3\u8005\u5e94\u5728\u542b\u94c2\u5316\u7597\u7ed3\u675f\u540e\u7684<span>12<\/span>\u5468\u5185\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u3002\uff08<span>2<\/span>\uff09\u590d\u53d1\u6027\u5375\u5de2\u764c\u7ef4\u6301\u6cbb\u7597\uff1a\u672c\u54c1\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u5929\u4e00\u6b21\u53e3\u670d<span>300mg<\/span>\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u4e0d\u826f\u53cd\u5e94\u3002\u5bf9\u4e8e\u4f53\u91cd\u4f4e\u4e8e<span>58kg<\/span>\u7684\u60a3\u8005\uff0c\u53ef\u8003\u8651<span>200mg<\/span>\u7684\u8d77\u59cb\u5242\u91cf\u3002\u590d\u53d1\u6027\u5375\u5de2\u764c\u7ef4\u6301\u6cbb\u7597\u7684\u60a3\u8005\u5e94\u5728\u542b\u94c2\u5316\u7597\u7ed3\u675f\u540e\u7684<span>8<\/span>\u5468\u5185\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u3002\uff08<span>3<\/span>\uff09\u7ecf\u8fc7\u4e09\u6b21\u6216\u4e09\u6b21\u4ee5\u4e0a\u5316\u7597\u540e\u7684\u665a\u671f\u5375\u5de2\u764c\u6cbb\u7597\uff1a\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u5929\u4e00\u6b21\u53e3\u670d<span>300mg<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u6bcf\u5929\u5927\u81f4\u76f8\u540c\u65f6\u95f4\u670d\u7528\uff0c\u5e94\u6574\u7c92\u541e\u670d\uff0c\u4e0d\u5e94\u6eb6\u89e3\u6216\u6253\u5f00\u80f6\u56ca\u3002\u5728\u8fdb\u9910\u6216\u7a7a\u8179\u65f6\u5747\u53ef\u670d\u7528\u3002\u7761\u524d\u7ed9\u836f\u53ef\u80fd\u4f1a\u6709\u5229\u4e8e\u63a7\u5236\u6076\u5fc3\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u60a3\u8005\u5455\u5410\u6216\u6f0f\u670d\u4e00\u5242\u836f\u7269\uff0c\u4e0d\u5e94\u8865\u670d\uff0c\u800c\u5e94\u5728\u7b2c\u4e8c\u5929\u7684\u5e38\u89c4\u65f6\u95f4\u670d\u7528\u4e0b\u4e00\u6b21\u5904\u65b9\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u60a3\u8005\u5e94\u5728\u65e2\u5f80\u6297\u80bf\u7624\u6cbb\u7597\u5f15\u8d77\u7684\u8840\u6db2\u5b66\u6bd2\u6027\u6062\u590d\u4e4b\u540e\uff08\u57fa\u7ebf\u8840\u6db2\u5b66\u53c2\u6570\u5fc5\u987b\u7b26\u5408\u4ee5\u4e0b\u6807\u51c6\uff1a\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u6570\u2265<span>1.5<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff0c\u8840\u5c0f\u677f\u2265<span>100<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff0c\u4e14\u8840\u7ea2\u86cb\u767d\u2265<span>90g\/L<\/span>\uff09\uff0c\u624d\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u3002\u5728\u6cbb\u7597\u6700\u521d\u7684<span>12<\/span>\u4e2a\u6708\u5185\uff0c\u63a8\u8350\u7b2c\u4e00\u4e2a\u6708\u5185\u6bcf\u5468\u68c0\u6d4b\u4e00\u6b21\u5168\u8840\u7ec6\u80de\u8ba1\u6570\uff0c\u5728\u63a5\u4e0b\u6765<span>11<\/span>\u4e2a\u6708\u7684\u6cbb\u7597\u4e2d\u6bcf\u6708\u68c0\u6d4b\u4e00\u6b21\uff0c<span>1<\/span>\u5e74\u540e\u5b9a\u671f\u68c0\u6d4b\u3002\u5982\u679c\u60a3\u8005\u53d1\u751f\u91cd\u5ea6\u6301\u7eed\u6027\u8840\u6db2\u5b66\u6bd2\u6027\u53cd\u5e94\uff0c\u4e14\u5728\u6682\u505c\u7528\u836f\u540e<span>28<\/span>\u5929\u5185\u4ecd\u672a\u597d\u8f6c\uff0c\u5e94\u505c\u7528\u672c\u54c1\uff0c\u5e76\u8f6c\u8bca\u60a3\u8005\u81f3\u8840\u6db2\u79d1\uff0c\u8fdb\u884c\u8fdb\u4e00\u6b65\u68c0\u67e5\uff0c\u5305\u62ec\u9aa8\u9ad3\u5206\u6790\u548c\u8840\u6db2\u6837\u672c\u9057\u4f20\u5b66\u5206\u6790\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5e38\u89c1\u7684\u5404\u7c7b\u4e0d\u826f\u53cd\u5e94\u4e3a\u8d2b\u8840\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u5fc3\u60b8\u3001\u6076\u5fc3\u3001\u5455\u5410\u3001\u8179\u6cfb\u3001\u4fbf\u79d8\u3001\u8179\u75db<span>\/<\/span>\u8179\u80c0\u3001\u6d88\u5316\u4e0d\u826f\u3001\u53e3\u5e72\u3001\u75b2\u4e4f\u3001\u98df\u6b32\u51cf\u9000\u3001\u6ccc\u5c3f\u7cfb\u7edf\u611f\u67d3\u3001<span>AST\/ALT<\/span>\u5347\u9ad8\u3001\u5173\u8282\u75db\u3001\u808c\u75db\u3001\u5934\u75db\u3001\u5934\u6655\u3001\u5473\u89c9\u969c\u788d\u3001\u5931\u7720\u7b49\u3002\u5c3c\u62c9\u5e15\u5229\u7528\u4e8e\u4e2d\u56fd\u94c2\u654f\u611f\u590d\u53d1\u5375\u5de2\u764c\u7ef4\u6301\u6cbb\u7597\u7684<span>NORA<\/span>\u7814\u7a76\u6570\u636e\u663e\u793a\u53d1\u751f\u7387\u6700\u9ad8\u7684\u4e0d\u826f\u53cd\u5e94\u4f9d\u6b21\u4e3a\u767d\u7ec6\u80de\u8ba1\u6570\u51cf\u5c11\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u548c\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\uff0c\u5927\u591a\u4e3a<span>1<\/span>\uff5e<span>2<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u7684\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u53d1\u751f\u7387\u4e3a<span>11.3%<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>4<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\u53ef\u901a\u8fc7\u5242\u91cf\u4e2d\u65ad\u548c\u5bf9\u75c7\u5904\u7406\u6765\u7ba1\u7406\u3002\u5bf9\u4e8e\u975e\u8840\u6db2\u5b66\u6bd2\u6027\uff0c\u5f85\u75c7\u72b6\u6062\u590d\u81f3\u2264<span>1<\/span>\u7ea7\u65f6\uff0c\u91cd\u65b0\u5f00\u59cb\u539f\u5242\u91cf\u6216\u51cf\u91cf\u6cbb\u7597\u3002\u5bf9\u4e8e\u8840\u6db2\u5b66\u6bd2\u6027\uff0c\u5f53\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u6570\u6062\u590d\u81f3\u2265<span>1.5<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff0c\u8840\u5c0f\u677f\u6062\u590d\u81f3\u2265<span>100<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff0c\u4e14\u8840\u7ea2\u86cb\u767d\u6062\u590d\u81f3\u2265<span>90g\/L<\/span>\u65f6\uff0c\u91cd\u65b0\u5f00\u59cb\u539f\u5242\u91cf\u6216\u51cf\u91cf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u9700\u8981\u51cf\u91cf\uff0c\u63a8\u8350\u5242\u91cf\u51cf\u81f3<span>200mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e00\u6b21\u3002\u9700\u8981\u8fdb\u4e00\u6b65\u51cf\u91cf\uff0c\u5219\u63a8\u8350\u5242\u91cf\u51cf\u81f3<span>100mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e00\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u901a\u8fc7\u7fa7\u9178\u916f\u9176\u8fdb\u884c\u4ee3\u8c22\uff0c\u5728\u4e0e<span>CYP<\/span>\u8bf1\u5bfc\u5242\u548c<span>CYP<\/span>\u6291\u5236\u5242\u5408\u5e76\u4f7f\u7528\u65f6\uff0c\u4e0d\u9700\u8981\u8c03\u6574\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u8f7b\u4e2d\u5ea6\u809d\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u4e0d\u9700\u8981\u8c03\u6574\u5242\u91cf\u3002\u5bf9\u4e8e\u91cd\u5ea6\u809d\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u5e94\u614e\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u65e2\u5f80\u5df2\u63a5\u53d7\u8fc7\u2265\u4e09\u6b21\u5316\u7597\u7684\u80bf\u7624\u540c\u6e90\u91cd\u7ec4\u4fee\u590d\u7f3a\u9677\u9633\u6027\u7684\u665a\u671f\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u764c\u6210\u4eba\u60a3\u8005\u7684\u6cbb\u7597\uff0c\u5176\u764c\u75c7\u5177\u6709\u4e0b\u8ff0\u7279\u5f81\u4e4b\u4e00\uff1a\u6709\u5bb3\u6216\u7591\u4f3c\u6709\u5bb3\u7684<span>BRCA<\/span>\u7a81\u53d8\uff0c\u6216\u57fa\u56e0\u7ec4\u4e0d\u7a33\u5b9a\u4e14\u672b\u6b21\u542b\u94c2\u5316\u7597\u5e94\u7b54\u540e\u8d85\u8fc7<span>6<\/span>\u4e2a\u6708\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e09\u3001\u6c1f\u5511\u5e15\u5229<span> Fluzoparib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>50mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u94c2\u654f\u611f\u7684\u590d\u53d1\u6027\u4e0a\u76ae\u6027\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u764c\u6210\u4eba\u60a3\u8005\u5728\u542b\u94c2\u5316\u7597\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u6216\u90e8\u5206\u7f13\u89e3\u540e\u7684\u7ef4\u6301\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u7ecf\u8fc7\u4e8c\u7ebf\u53ca\u4ee5\u4e0a\u5316\u7597\u7684\u4f34\u6709\u80da\u7cfb<span>BRCA<\/span>\u7a81\u53d8\u7684\u94c2\u654f\u611f\u590d\u53d1\u6027\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a<span>150mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\uff08\u65e9\u665a\u5404\u4e00\u6b21\uff09\uff0c\u5373\u6bcf\u5929\u603b\u5242\u91cf\u4e3a<span>300mg<\/span>\u3002\u60a3\u8005\u5728\u5f00\u59cb\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u540e\uff0c\u5e94\u6301\u7eed\u6cbb\u7597\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u53d1\u751f\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u53cd\u5e94\u3002\u9488\u5bf9\u94c2\u654f\u611f\u590d\u53d1\u6027\u5375\u5de2\u764c\u7684\u7ef4\u6301\u6cbb\u7597\uff0c\u60a3\u8005\u5e94\u5728\u542b\u94c2\u5316\u7597\u7ed3\u675f\u540e\u7684<span>4<\/span>\uff5e<span>8<\/span>\u5468\u5185\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53e3\u670d\u7ed9\u836f\uff0c\u5e94\u6574\u7c92\u541e\u670d\u3002\u5728\u8fdb\u9910\u6216\u7a7a\u8179\u65f6\u5747\u53ef\u670d\u7528\uff08\u63a8\u8350\u8fdb\u9910\u540e\u670d\u7528\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u60a3\u8005\u6f0f\u670d\u4e00\u5242\u836f\u7269\uff0c\u65e0\u9700\u8865\u670d\uff0c\u4ecd\u6309\u8ba1\u5212\u65f6\u95f4\u6b63\u5e38\u670d\u7528\u4e0b\u4e00\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u60a3\u8005\u5e94\u5728\u65e2\u5f80\u6297\u80bf\u7624\u6cbb\u7597\u5f15\u8d77\u7684\u8840\u6db2\u5b66\u6bd2\u6027\u6062\u590d\u4e4b\u540e\uff08\u8840\u7ea2\u86cb\u767d\u3001\u8840\u5c0f\u677f\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u6c34\u5e73\u5e94\u6062\u590d\u81f3\u2264<span>CTCAE 1<\/span>\u7ea7\uff09\uff0c\u624d\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u3002\u5728\u6cbb\u7597\u6700\u521d\u7684<span>3<\/span>\u4e2a\u6708\u5185\uff0c\u63a8\u8350\u5728\u57fa\u7ebf\u8fdb\u884c\u5168\u8840\u7ec6\u80de\u68c0\u6d4b\uff0c\u968f\u540e\u6bcf<span>2<\/span>\u5468\u76d1\u6d4b\u4e00\u6b21\uff0c\u4e4b\u540e\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u671f\u95f4\u51fa\u73b0\u7684\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u53c2\u6570\u53d8\u5316\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u60a3\u8005\u51fa\u73b0\u91cd\u5ea6\u6216\u8f93\u8840\u4f9d\u8d56\u6027\u7684\u8840\u6db2\u5b66\u6bd2\u6027\uff0c\u5e94\u4e2d\u65ad\u6cbb\u7597\uff0c\u5e76\u4e14\u5e94\u8fdb\u884c\u76f8\u5173\u7684\u8840\u6db2\u5b66\u68c0\u6d4b\u3002\u5982\u679c\u672c\u54c1\u7ed9\u836f\u4e2d\u65ad<span>4<\/span>\u5468\u540e\u8840\u6db2\u6307\u6807\u4ecd\u5b58\u5728\u4e34\u5e8a\u5f02\u5e38\uff0c\u5219\u63a8\u8350\u9aa8\u9ad3\u5206\u6790\u548c<span>\/<\/span>\u6216\u8840\u7ec6\u80de\u9057\u4f20\u5b66\u5206\u6790\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5e38\u89c1\u7684\u5404\u7c7b\u4e0d\u826f\u53cd\u5e94\uff08\u53d1\u751f\u7387\u2265<span>10%<\/span>\uff0c\u6309\u53d1\u751f\u7387\u9ad8\u4f4e\u6392\u5e8f\uff09\u5206\u522b\u4e3a\u8d2b\u8840\u3001\u6076\u5fc3\u3001\u767d\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u4e4f\u529b\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u5455\u5410\u3001\u98df\u6b32\u51cf\u9000\u3001\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u8840\u808c\u9150\u5347\u9ad8\u3001<span>ALT<\/span>\u5347\u9ad8\u3002\u5927\u591a\u4e3a<span>1<\/span>\uff5e<span>2<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c<span>3<\/span>\u7ea7\u53ca\u4ee5\u4e0a\u4e0d\u826f\u53cd\u5e94\uff08\u53d1\u751f\u7387\u2265<span>2%<\/span>\uff09\u5305\u62ec\uff1a\u8d2b\u8840\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u767d\u7ec6\u80de\u51cf\u5c11\u75c7\u548c\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u75c7\u3002\u591a\u6570\u4e0d\u826f\u53cd\u5e94\u901a\u8fc7\u5242\u91cf\u6682\u505c\u6216\u7ea0\u6b63\u6cbb\u7597\u5747\u80fd\u6062\u590d\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>4<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\u53ef\u901a\u8fc7\u5242\u91cf\u4e2d\u65ad\u6765\u7ba1\u7406\u3002\u5f85\u75c7\u72b6\u6062\u590d\u81f3\u2264<span>1<\/span>\u7ea7\u65f6\uff0c\u91cd\u65b0\u5f00\u59cb\u539f\u5242\u91cf\u6216\u51cf\u91cf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u9700\u8981\u51cf\u91cf\uff0c\u63a8\u8350\u5242\u91cf\u51cf\u81f3<span>100mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u5373\u6bcf\u5929\u603b\u5242\u91cf\u4e3a<span>200mg<\/span>\u3002\u5982\u679c\u9700\u8981\u8fdb\u4e00\u6b65\u51cf\u91cf\uff0c\u5219\u63a8\u8350\u5242\u91cf\u51cf\u81f3<span>50mg<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\/<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b21<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u5373\u6bcf\u5929\u603b\u5242\u91cf\u4e3a<span>100mg<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u907f\u514d\u5408\u5e76\u4f7f\u7528<span>CYP3A4<\/span>\u5f3a\u6291\u5236\u5242\u3002\u5982\u5fc5\u987b\u4f7f\u7528\uff0c\u53ef\u4ee5\u505c\u7528\u6c1f\u5511\u5e15\u5229\uff1b\u5728\u505c\u6b62\u5408\u5e76\u4f7f\u7528<span>CYP3A4<\/span>\u5f3a\u6291\u5236\u5242\u4e14\u81f3\u8be5\u836f\u7269\u6e05\u9664<span>5<\/span>\uff5e<span>7<\/span>\u4e2a\u534a\u8870\u671f\u540e\uff0c\u53ef\u6062\u590d\u6c1f\u5511\u5e15\u5229\u81f3\u539f\u7ed9\u836f\u5242\u91cf\u548c\u9891\u7387\u3002\u5982\u4e0e<span>CYP3A4<\/span>\u4e2d\u7b49\u6291\u5236\u5242\u5408\u7528\u65f6\uff0c\u5efa\u8bae\u4e0b\u8c03\u6c1f\u5511\u5e15\u5229\u5242\u91cf\u81f3<span>50mg<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56db\u3001\u5e15\u7c73\u5e15\u5229<span> Pamiparib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>20mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u7c73\u5e15\u5229\u9002\u7528\u4e8e\u65e2\u5f80\u7ecf\u8fc7\u4e8c\u7ebf\u53ca\u4ee5\u4e0a\u5316\u7597\u7684\u4f34\u6709\u80da\u7cfb<span>BRCA<\/span>\u7a81\u53d8\u7684\u590d\u53d1\u6027\u665a\u671f\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u7c73\u5e15\u5229\u63a8\u8350\u5242\u91cf\u4e3a<span>60mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u6301\u7eed\u6cbb\u7597\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u53d1\u751f\u4e0d\u53ef\u8010\u53d7\u7684\u4e0d\u826f\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u60a3\u8005\u5728\u6bcf\u5929\u5927\u81f4\u76f8\u540c\u65f6\u95f4\u70b9\u53e3\u670d\u7ed9\u836f\uff0c\u672c\u54c1\u5e94\u6574\u7c92\u541e\u670d\uff0c\u4e0d\u5e94\u5480\u56bc\u3001\u538b\u788e\u3001\u6eb6\u89e3\u6216\u6253\u5f00\u80f6\u56ca\u3002\u672c\u54c1\u5728\u8fdb\u9910\u6216\u7a7a\u8179\u65f6\u5747\u53ef\u670d\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u60a3\u8005\u53d1\u751f\u5455\u5410\u6216\u6f0f\u670d\u4e00\u6b21\u836f\u7269\uff0c\u4e0d\u5e94\u989d\u5916\u8865\u670d\uff0c\u5e94\u6309\u8ba1\u5212\u65f6\u95f4\u6b63\u5e38\u670d\u7528\u4e0b\u4e00\u6b21\u5904\u65b9\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u7684<span>317<\/span>\u4f8b\u60a3\u8005\u4e2d<span>[BGB-290-102<\/span>\u60a3\u8005\u4f8b\u6570\uff08<span>N<\/span>\uff09<span>=128<\/span>\u3001<span>BGB-290-AU-002<\/span>\uff08<span>N<\/span>\uff09<span>=101<\/span>\u548c<span>BGB-290-201<\/span>\uff08<span>N<\/span>\uff09<span>=88]<\/span>\uff0c\u53d1\u751f\u7387\u2265<span>10%<\/span>\u7684\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\uff1a\u8d2b\u8840\u3001\u6076\u5fc3\u3001\u767d\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u5455\u5410\u3001\u75b2\u4e4f\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3001\u98df\u6b32\u51cf\u9000\u3001\u8179\u6cfb\u3001\u8179\u75db\u3001<span>AST<\/span>\u5347\u9ad8\u3001<span>ALT<\/span>\u5347\u9ad8\u3001\u8840\u80c6\u7ea2\u7d20\u5347\u9ad8\u4ee5\u53ca\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u75c7\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e3a\u7ba1\u7406\u5e15\u7c73\u5e15\u5229\u7684\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94\uff0c\u9700\u5b9a\u671f\u68c0\u6d4b\u5168\u8840\u7ec6\u80de\u8ba1\u6570\u3002\u5efa\u8bae\u5728\u6cbb\u7597\u7684\u524d<span>3<\/span>\u4e2a\u6708\u5185\u6bcf\u5468\u68c0\u6d4b\u4e00\u6b21\uff0c\u4e4b\u540e\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u671f\u95f4\u51fa\u73b0\u7684\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u53c2\u6570\u53d8\u5316\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e3a\u7ba1\u7406\u836f\u7269\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\u8003\u8651\u6682\u505c\u6cbb\u7597\u6216\u51cf\u91cf\u3002\u7b2c\u4e00\u6b21\u63a8\u8350\u5242\u91cf\u51cf\u81f3<span>40mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\u3002\u5982\u679c\u9700\u8981\u8fdb\u4e00\u6b65\u51cf\u91cf\uff0c\u5219\u63a8\u8350\u5242\u91cf\u51cf\u81f3<span>20mg<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\/<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b21<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u6bcf\u5929\u4e24\u6b21\u3002\u9488\u5bf9\u975e\u8840\u6db2\u5b66\u548c\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94\u7684\u5242\u91cf\u8c03\u6574\u8981\u6c42\u53c2\u89c1\u8868<span>10<\/span>\u548c\u8868<span>11<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8868<span>10<\/span>&emsp;\u9488\u5bf9\u975e\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94\u7684\u5242\u91cf\u8c03\u6574<span><\/span><\/span><\/b>\n<\/p>\n<table class=\"MsoTableGrid\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\" style=\"border-collapse:collapse;border:none;\">\n<tbody>\n<tr>\n<td width=\"568\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u826f\u53cd\u5e94<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"568\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u8c03\u6574<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"568\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">CTCAE<sup>*<\/sup>3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\u975e\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94\uff0c\u4e0d\u80fd\u901a\u8fc7\u9884\u9632\u6cbb\u7597\uff0c\u6216\u7ecf\u8fc7\u6cbb\u7597\u4e0d\u826f\u53cd\u5e94\u4ecd\u6301\u7eed\u5b58\u5728<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"568\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u670d\u7528\u672c\u54c1\u4e0d\u8d85\u8fc7<span>28<\/span>\u5929\u76f4\u81f3\u4e0d\u826f\u53cd\u5e94\u7f13\u89e3<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u4e0b\u8c03\u7684\u5242\u91cf\u4e0b\u6062\u590d\u672c\u54c1\u6cbb\u7597<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"568\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u540e\u6301\u7eed\u5b58\u5728\u7684<span>CTCAE 4<\/span>\u7ea7\u975e\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"568\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<sup><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">*<\/span><\/sup><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\uff1a\u6309\u7167\u7f8e\u56fd\u56fd\u7acb\u764c\u75c7\u7814\u7a76\u6240\u7684\u4e0d\u826f\u4e8b\u4ef6\u901a\u7528\u672f\u8bed\u8bc4\u4f30\u6807\u51c6<span>4.03<\/span>\u7248\uff08<span>NCI-CTCAEv4.03<\/span>\uff09\u786e\u5b9a\u4e25\u91cd\u7a0b\u5ea6\u5206\u7ea7\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8868<span>11<\/span>&emsp;\u9488\u5bf9\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94\u7684\u5242\u91cf\u8c03\u6574<span><\/span><\/span><\/b>\n<\/p>\n<table class=\"MsoTableGrid\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\" style=\"border-collapse:collapse;border:none;\">\n<tbody>\n<tr>\n<td width=\"279\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u826f\u53cd\u5e94<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"857\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u8c03\u6574<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"279\" rowspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d2b\u8840<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08\u8840\u7ea2\u86cb\u767d\uff1c<span>90g\/L<\/span>\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"857\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9996\u6b21\u53d1\u751f\uff1a<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\u5e76\u9075\u533b\u5631\u6cbb\u7597\u76f4\u81f3\u8840\u7ea2\u86cb\u767d\u6062\u590d\u81f3<\/span><span style=\"font-size:14pt;line-height:150%;\"> <\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2265<span>90<\/span><\/span><span style=\"font-size:14pt;line-height:150%;\"> <\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">g\/L<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u6c34\u5e73\u4ee5<span>40mg<\/span>\u6bcf\u5929\u4e24\u6b21\u7ed9\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"857\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u518d\u6b21\u53d1\u751f\uff1a<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u4e8e\u4e34\u5e8a\u8bc4\u4f30\u7ed9\u4e88\u9002\u5f53\u7684\u652f\u6301\u6027\u6cbb\u7597\u5e76\u7ee7\u7eed\u4ee5<span>40mg<\/span>\u6bcf\u5929\u4e24\u6b21\u7ed9\u836f\uff0c\u6216\u8005<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\u5e76\u9075\u533b\u5631\u6cbb\u7597\u76f4\u81f3\u8840\u7ea2\u86cb\u767d\u6062\u590d\u81f3\u2265<span>90g\/L<\/span>\uff0c\u4ee5<span>40mg<\/span>\u6bcf\u5929\u4e24\u6b21\u7ee7\u7eed\u7ed9\u836f\uff0c\u6216\u8005<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\u5e76\u9075\u533b\u5631\u6cbb\u7597\u76f4\u81f3\u8840\u7ea2\u86cb\u767d\u6062\u590d\u81f3\u2265<\/span><span style=\"font-size:14pt;line-height:150%;\"> <\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">90g\/L<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u6c34\u5e73\u4ee5<span>20mg<\/span>\u6bcf\u5929\u4e24\u6b21\u7ed9\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u82e5\u8d2b\u8840\u5371\u53ca\u751f\u547d\uff0c\u9700\u7d27\u6025\u6cbb\u7597\uff1a<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\u5e76\u9075\u533b\u5631\u6cbb\u7597\u76f4\u81f3\u8840\u7ea2\u86cb\u767d\u6062\u590d\u81f3\u2265<span>90g\/L<\/span>\uff0c\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u6c34\u5e73\u4ee5<span>20mg<\/span>\u6bcf\u5929\u4e24\u6b21\u7ed9\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728<span>20mg<\/span>\u6bcf\u5929\u4e24\u6b21\u5242\u91cf\u6c34\u5e73\u518d\u6b21\u51fa\u73b0\u8d2b\u8840\u5371\u53ca\u751f\u547d\uff0c\u4e14\u8d2b\u8840\u4e0d\u662f\u7531\u4e8e\u5176\u4ed6\u5e72\u6270\u4e8b\u4ef6\uff08\u5982\u80c3\u80a0\u9053\u51fa\u8840\uff09\u5f15\u8d77\uff0c\u5e94\u505c\u7528\u672c\u54c1<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"279\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11<span>[<\/span>\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u8ba1\u6570\uff08<span>ANC<\/span>\uff09\uff1c<span>1<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u6216\u53d1\u70ed\u6027\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7<span>]<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"857\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\uff0c\u76f4\u81f3\u6062\u590d\u81f3<span>ANC<\/span>\u2265<\/span><span style=\"font-size:14pt;line-height:150%;\"> <\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.5\u00d710<sup>9<\/sup>\/L<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6216\u53d1\u70ed\u6027\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u7f13\u89e3\uff0c\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u6c34\u5e73\u7ed9\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"279\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8840\u5c0f\u677f\u51cf\u5c11<span>[<\/span>\u8840\u5c0f\u677f\u8ba1\u6570\uff08<span>PLT<\/span>\uff09\uff1c<span>50<\/span>\u00d7<span>10<sup>9<\/sup>\/L]<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"857\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\uff0c\u76f4\u5230\u6062\u590d\u81f3<span>PLT<\/span>\u2265<span>75<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u6216\u57fa\u7ebf\u6c34\u5e73\uff0c\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u6c34\u5e73\u7ed9\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5141\u8bb8\u5408\u5e76\u4f7f\u7528\u5f3a\u6548<span>\/<\/span>\u4e2d\u6548<span>\/<\/span>\u8f7b\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\uff0c\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u9644\u8868<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"margin-left:24.0pt;text-indent:119.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9644\u8868<span>1 <\/span><\/span><\/b><b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u548c<\/span><\/b><b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u8c03\u6574\u65b9\u6848<span><\/span><\/span><\/b>\n<\/p>\n<table class=\"MsoNormalTable\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"1134\" style=\"border-collapse:collapse;border:none;\">\n<tbody>\n<tr>\n<td width=\"174\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e25\u91cd\u7a0b\u5ea6<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u8c03\u6574<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"174\" rowspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7<sup><span><\/span><\/sup><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7528\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"174\" rowspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80ba\u708e<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\uff0c\u76f4\u81f3\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u81f3<span>0<\/span>\uff5e<span>1<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>4<\/span>\u7ea7\u6216\u590d\u53d1\u6027<span>2<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"174\" rowspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8179\u6cfb\u53ca\u7ed3\u80a0\u708e<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\u6216<span>3<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\uff0c\u76f4\u81f3\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u81f3<span>0<\/span>\uff5e<span>1<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"174\" rowspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u809d\u708e<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\uff0c\u5929\u95e8\u51ac\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08<span>AST<\/span>\uff09\u6216\u4e19\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08<span>ALT<\/span>\uff09\u5728<span>3<\/span>\uff5e<span>5<\/span>\u500d\u6b63\u5e38\u503c\u4e0a\u9650\uff08<span>ULN<\/span>\uff09\u6216\u603b\u80c6\u7ea2\u7d20\uff08<span>TBIL<\/span>\uff09\u5728<span>1.5<\/span>\uff5e<span>3<\/span>\u500d<span>ULN<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\uff0c\u76f4\u81f3\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u81f3<span>0<\/span>\uff5e<span>1<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>4<\/span>\u7ea7\uff0c<span>AST<\/span>\u6216<span>ALT<\/span>\uff1e<span>5<\/span>\u500d<span>ULN<\/span>\uff0c\u6216<span>TBIL<\/span>\uff1e<span>3<\/span>\u500d<span>ULN<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"174\" rowspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80be\u708e<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>3<\/span>\u7ea7\u8840\u808c\u9150\u5347\u9ad8<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\uff0c\u76f4\u81f3\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u81f3<span>0<\/span>\uff5e<span>1<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\u8840\u808c\u9150\u5347\u9ad8<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"174\" rowspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5185\u5206\u6ccc\u75be\u75c5<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u75c7\u72b6\u6027<span>2<\/span>\uff5e<span>3<\/span>\u7ea7\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\uff0c<span>2<\/span>\uff5e<span>3<\/span>\u7ea7\u7532\u72b6\u817a\u529f\u80fd\u4ea2\u8fdb\u3001<span>2<\/span>\uff5e<span>3<\/span>\u7ea7\u5782\u4f53\u708e\u3001<span>2<\/span>\u7ea7\u80be\u4e0a\u817a\u529f\u80fd\u4e0d\u5168<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\u9ad8\u8840\u7cd6\u75c7\u6216<span>1<\/span>\u578b\u7cd6\u5c3f\u75c5<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\uff0c\u76f4\u81f3\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u81f3<span>0<\/span>\uff5e<span>1<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\u7532\u72b6\u817a\u529f\u80fd\u4ea2\u8fdb<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\u5782\u4f53\u708e<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>4<\/span>\u7ea7\u80be\u4e0a\u817a\u529f\u80fd\u4e0d\u5168<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\u9ad8\u8840\u7cd6\u75c7\u6216<span>1<\/span>\u578b\u7cd6\u5c3f\u75c5<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"174\" rowspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ae\u80a4\u4e0d\u826f\u53cd\u5e94<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\uff0c\u76f4\u81f3\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u81f3<span>0<\/span>\uff5e<span>1<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\uff0c<span>Stevens-Johnson<\/span>\u7efc\u5408\u5f81\u6216\u4e2d\u6bd2\u6027\u8868\u76ae\u574f\u6b7b\u677e\u89e3\u75c7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"174\" rowspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8840\u5c0f\u677f\u51cf\u5c11\u75c7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\uff0c\u76f4\u81f3\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u81f3<span>0<\/span>\uff5e<span>1<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"174\" rowspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5176\u4ed6\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>4<\/span>\u7ea7\u8840\u6dc0\u7c89\u9176\u5347\u9ad8\u6216\u8102\u80aa\u9176\u5347\u9ad8<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>3<\/span>\u7ea7\u80f0\u817a\u708e<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\u5fc3\u808c\u708e<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>3<\/span>\u7ea7\u9996\u6b21\u53d1\u751f\u7684\u5176\u4ed6\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\uff0c\u76f4\u81f3\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u81f3<span>0<\/span>\uff5e<span>1<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\u80f0\u817a\u708e\u6216\u4efb\u4f55\u7ea7\u522b\u7684\u590d\u53d1\u6027\u80f0\u817a\u708e<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>4<\/span>\u7ea7\u5fc3\u808c\u708e<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>4<\/span>\u7ea7\u8111\u708e<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\u9996\u6b21\u53d1\u751f\u7684\u5176\u4ed6\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"174\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u590d\u53d1\u6216\u6301\u7eed\u7684\u4e0d\u826f\u53cd\u5e94<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u590d\u53d1\u6027<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\uff08\u9664\u5916\u5185\u5206\u6ccc\u75be\u75c5\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672b\u6b21\u7ed9\u836f\u540e<span>12<\/span>\u5468\u5185<span>2<\/span>\uff5e<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672a\u6539\u5584\u5230<span>0<\/span>\uff5e<span>1<\/span>\u7ea7\uff08\u9664\u5916\u5185\u5206\u6ccc\u75be\u75c5\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672b\u6b21\u7ed9\u836f\u540e<span>12<\/span>\u5468\u5185\u7cd6\u76ae\u8d28\u6fc0\u7d20\u672a\u80fd\u964d\u81f3\u2264<span>10mg\/d<\/span>\u7684\u5f3a\u7684\u677e\u7b49\u6548\u5242\u91cf<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"174\" rowspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f93\u6db2\u53cd\u5e94<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u964d\u4f4e\u6ef4\u901f\u6216\u6682\u505c\u7ed9\u836f\uff0c\u5f53\u75c7\u72b6\u7f13\u89e3\u540e\u53ef\u8003\u8651\u6062\u590d\u7528\u836f\u5e76\u5bc6\u5207\u89c2\u5bdf<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>4<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p><b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\"><br \/>\n<\/span><\/b> <\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9644\u8868<span>2 <\/span>\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u5206\u7ea7\u6807\u51c6\u548c\u6cbb\u7597\u5efa\u8bae<span><\/span><\/span><\/b>\n<\/p>\n<table class=\"MsoNormalTable\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"1136\" style=\"border-collapse:collapse;border:none;\">\n<tbody>\n<tr>\n<td width=\"128\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5206\u7ea7<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"359\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e34\u5e8a\u8868\u73b0<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"649\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u5efa\u8bae<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"128\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"359\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5355\u4e2a\u6700\u5927\u76f4\u5f84<span>\u226410mm<\/span>\uff0c\u4f34\u6216\u4e0d\u4f34\u7834\u6e83\u51fa\u8840<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"649\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ee7\u7eed\u7528\u836f\uff0c\u6613\u6469\u64e6\u90e8\u4f4d\u53ef\u7528\u7eb1\u5e03\u4fdd\u62a4\uff0c\u907f\u514d\u51fa\u8840\u3002\u7834\u6e83\u51fa\u8840\u8005\u53ef\u91c7\u7528\u5c40\u90e8\u538b\u8feb\u6b62\u8840\u6cbb\u7597<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"128\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"359\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5355\u4e2a\u6700\u5927\u76f4\u5f84\uff1e<span>10mm<\/span>\uff0c\u4f34\u6216\u4e0d\u4f34\u7834\u6e83\u51fa\u8840<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"649\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ee7\u7eed\u7528\u836f\uff0c\u6613\u6469\u64e6\u90e8\u4f4d\u53ef\u7528\u7eb1\u5e03\u4fdd\u62a4\uff0c\u907f\u514d\u51fa\u8840\u3002\u7834\u6e83\u51fa\u8840\u8005\u53ef\u5c40\u90e8\u538b\u8feb\u6b62\u8840\uff0c\u6216\u91c7\u53d6\u5c40\u90e8\u6cbb\u7597\u63aa\u65bd\uff0c\u5982\u6fc0\u5149\u6216\u624b\u672f\u5207\u9664\u7b49\u3002\u907f\u514d\u7834\u6e83\u5904\u611f\u67d3<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"128\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"359\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5448\u6cdb\u53d1\u6027\uff0c\u53ef\u4ee5\u5e76\u53d1\u76ae\u80a4\u611f\u67d3\uff0c\u53ef\u80fd\u9700\u8981\u4f4f\u9662\u6cbb\u7597<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"649\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7528\u836f\uff0c\u5f85\u6062\u590d\u81f3<span>\u22641<\/span>\u7ea7\u540e\u6062\u590d\u7ed9\u836f\uff0c\u6613\u6469\u64e6\u90e8\u4f4d\u53ef\u7528\u7eb1\u5e03\u4fdd\u62a4\uff0c\u907f\u514d\u51fa\u8840\u3002\u7834\u6e83\u51fa\u8840\u8005\u53ef\u5c40\u90e8\u538b\u8feb\u6b62\u8840\uff0c\u6216\u91c7\u53d6\u5c40\u90e8\u6cbb\u7597\u63aa\u65bd\u5982\u6fc0\u5149\u6216\u624b\u672f\u5207\u9664\u7b49\uff0c\u5e76\u53d1\u611f\u67d3\u8005\u7ed9\u4e88\u6297\u611f\u67d3\u6cbb\u7597<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"128\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"359\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u591a\u53d1\u548c\u6cdb\u53d1\uff0c\u5a01\u80c1\u751f\u547d<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"649\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"128\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"359\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b7b\u4ea1<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"649\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;color:#333333;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span><span style=\"font-family:\" font-size:18pt;\"=\"\">\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u529e\u516c\u5385\u5173\u4e8e\u5370\u53d1\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219\uff08<\/span><span style=\"font-family:\" font-size:18pt;\"=\"\">2021<\/span><span style=\"font-family:\" font-size:18pt;\"=\"\">\u5e74\u7248\uff09\u7684\u901a\u77e5<\/span>\n<\/p>\n<div class=\"WordSection1\">\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t\t<span style=\"font-size:12.0pt;font-family:\u7b49\u7ebf;color:#333333;\">\u53d1\u5e03\u65f6\u95f4\uff1a<span>2021-12-28<\/span><\/span>\n\t<\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;color:#444444;\">\u5404\u7701\u81ea\u6cbb\u533a\u76f4\u8f96\u5e02\u53ca\u65b0\u7586\u751f\u4ea7\u5efa\u8bbe\u5175\u56e2\u536b\u751f\u5065\u5eb7\u59d4\uff1a<span><\/span><\/span>\n\t<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:21pt;\">\n\t\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;color:#444444;\">\u4e3a\u8fdb\u4e00\u6b65\u89c4\u8303\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\uff0c\u6211\u59d4\u7ec4\u7ec7\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u5408\u7406\u7528\u836f\u4e13\u5bb6\u59d4\u5458\u4f1a\u7275\u5934\u5bf9\u300a\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219<span>(2020<\/span>\u5e74\u7248<span>)<\/span>\u300b\u8fdb\u884c\u4fee\u6539\u5b8c\u5584\uff0c\u5236\u5b9a\u4e86\u300a\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219<span>(2021<\/span>\u5e74\u7248<span>)<\/span>\u300b<span>(<\/span>\u53ef\u5728\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u7f51\u7ad9<span>\u201c<\/span>\u533b\u653f\u533b\u7ba1<span>\u201d<\/span>\u680f\u76ee\u4e0b\u8f7d<span>)<\/span>\u3002\u73b0\u5370\u53d1\u4f60\u4eec\uff0c\u8bf7\u8ba4\u771f\u7ec4\u7ec7\u5b66\u4e60\uff0c\u5e76\u8d2f\u5f7b\u6267\u884c\u3002<span><\/span><\/span>\n\t<\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t\t<span><a href=\"http:\/\/clponline.yiaiwang.cn\/d\/file\/p\/2021\/12-28\/b532977d886e821b4bcca257e08a7797.doc\" target=\"_blank\"><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;color:black;\"><span>\u9644\u4ef6\uff1a<\/span><\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;color:black;\"><span> <\/span><\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;color:black;\"><span>\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219(2021<\/span><\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;color:black;\"><span>\u5e74\u7248)<\/span><\/span><\/a><\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\"><\/p>\n<p><\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;color:#444444;\"><\/span>\n\t<\/p>\n<p class=\"MsoNormal\" align=\"right\" style=\"text-align:right;text-indent:21.0pt;\">\n\t\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;color:#444444;\">&emsp;&emsp;\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u529e\u516c\u5385<span><\/span><\/span>\n\t<\/p>\n<p class=\"MsoNormal\" align=\"right\" style=\"text-align:right;text-indent:21.0pt;\">\n\t\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;color:#444444;\">&emsp;&emsp;<span>2021<\/span>\u5e74<span>12<\/span>\u6708<span>20<\/span>\u65e5<span><\/span><\/span>\n\t<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span>\n\t<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n\t<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t\t<b><span style=\"font-size:24.0pt;line-height:150%;font-family:\u5b8b\u4f53;\"><\/span><\/b>\n\t<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t\t<b><span style=\"font-size:24.0pt;line-height:150%;font-family:\u5b8b\u4f53;\"><\/span><\/b>\n\t<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t\t<b><span style=\"font-size:24.0pt;line-height:150%;font-family:\u5b8b\u4f53;\"><\/span><\/b>\n\t<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t\t<b><span style=\"font-size:24.0pt;line-height:150%;font-family:\u5b8b\u4f53;\"><\/span><\/b>\n\t<\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t\t<span style=\"font-size:18.0pt;line-height:150%;font-family:;\" \"=\"\">\u9644\u4ef6\uff1a<span><\/span><\/span>\n\t<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t\t<span style=\"font-size:18.0pt;line-height:150%;font-family:;\" \"=\"\">\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219<\/span><span style=\"font-size:18.0pt;line-height:150%;font-family:;\" \"=\"\"><\/span>\n\t<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t\t<span style=\"font-size:18.0pt;line-height:150%;font-family:;\" \"=\"\">\uff08<span>2021<\/span>\u5e74\u7248\uff09<\/span><span style=\"font-size:18.0pt;line-height:150%;font-family:;\" \"=\"\"><\/span>\n\t<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:36.15pt;\">\n\t\t<b><span style=\"font-size:18.0pt;line-height:150%;font-family:\u5b8b\u4f53;\">\u76ee \u5f55<\/span><\/b><span style=\"font-size:18.0pt;line-height:150%;font-family:\u5b8b\u4f53;\"><\/span>\n\t<\/p>\n<p class=\"MsoNormal\">\n\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7b2c\u4e00\u90e8\u5206&emsp;\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u57fa\u672c\u539f\u5219<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n\t<\/p>\n<table class=\"MsoNormalTable ke-zeroborder\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"1059\" style=\"border-collapse:collapse;\">\n<tbody>\n<tr>\n<td width=\"1059\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e00\u3001\u75c5\u7406\u7ec4\u7ec7\u5b66\u786e\u8bca\u540e\u65b9\u53ef\u4f7f\u7528\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1059\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u9776\u70b9\u68c0\u6d4b\u540e\u65b9\u53ef\u4f7f\u7528\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1059\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e09\u3001\u4e25\u683c\u9075\u5faa\u9002\u5e94\u8bc1\u7528\u836f\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1059\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u56db\u3001\u4f53\u73b0\u60a3\u8005\u6cbb\u7597\u4ef7\u503c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1059\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e94\u3001\u7279\u6b8a\u60c5\u51b5\u4e0b\u7684\u836f\u7269\u5408\u7406\u4f7f\u7528\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516d\u3001\u91cd\u89c6\u836f\u7269\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:5.25pt;\">\n\t\t\t\t\t\t<span style=\"line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\">\n\t\t<b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\">\u7b2c\u4e8c\u90e8\u5206&emsp;\u5404\u7cfb\u7edf\u80bf\u7624\u7684\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219<\/span><\/b><b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n\t<\/p>\n<p class=\"MsoNormal\">\n\t\t<b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\">\u547c\u5438\u7cfb\u7edf\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n\t<\/p>\n<table class=\"MsoNormalTable ke-zeroborder\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"1058\" style=\"border-collapse:collapse;\">\n<tbody>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e00\u3001\u5409\u975e\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u5384\u6d1b\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e09\u3001\u57c3\u514b\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u56db\u3001\u963f\u6cd5\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e94\u3001\u8fbe\u53ef\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516d\u3001\u5965\u5e0c\u66ff\u5c3c<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e03\u3001\u963f\u7f8e\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516b\u3001\u4f0f\u7f8e\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e5d\u3001\u514b\u5511\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u3001\u963f\u6765\u66ff\u5c3c<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e00\u3001\u585e\u745e\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e8c\u3001\u6069\u6c99\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e09\u3001\u8d1d\u4f10\u73e0\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u56db\u3001\u91cd\u7ec4\u4eba\u8840\u7ba1\u5185\u76ae\u6291\u5236\u7d20\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e94\u3001\u5b89\u7f57\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u516d\u3001<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u4f9d\u7ef4\u83ab\u53f8<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e03\u3001\u666e\u62c9\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u516b\u3001\u8d5b\u6c83\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e5d\u3001\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u3001\u5e15\u535a\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e00\u3001\u5ea6\u4f10\u5229\u5c24\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e8c\u3001\u963f\u66ff\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e09\u3001\u5361\u745e\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u56db\u3001\u66ff\u96f7\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e94\u3001\u4fe1\u8fea\u5229\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u516d\u3001\u4f0a\u5339\u6728\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\">\n\t\t<b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\">\u6d88\u5316\u7cfb\u7edf\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n\t<\/p>\n<table class=\"MsoNormalTable ke-zeroborder\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"1058\" style=\"border-collapse:collapse;\">\n<tbody>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e00\u3001\u7d22\u62c9\u975e\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u745e\u6208\u975e\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e09\u3001\u4ed1\u4f10\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u56db\u3001\u591a\u7eb3\u975e\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e94\u3001\u963f\u66ff\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516d\u3001\u4fe1\u8fea\u5229\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e03\u3001\u5361\u745e\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516b\u3001\u66ff\u96f7\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e5d\u3001\u5e15\u535a\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u3001\u66f2\u59a5\u73e0\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e00\u3001\u963f\u5e15\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e8c\u3001\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e09\u3001\u7ef4\u8fea\u897f\u59a5\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u56db\u3001\u4f0a\u9a6c\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e94\u3001\u8212\u5c3c\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u516d\u3001\u963f\u4f10\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e03\u3001\u745e\u6d3e\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u516b\u3001\u4f9d\u7ef4\u83ab\u53f8\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e5d\u3001\u7d22\u51e1\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u3001<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1058\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e00\u3001\u897f\u59a5\u6614<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e8c\u3001\u544b\u55b9\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\">\n\t\t<b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\">\u8840\u6db2\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n\t<\/p>\n<table class=\"MsoNormalTable ke-zeroborder\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"1061\" style=\"border-collapse:collapse;\">\n<tbody>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e00\u3001\u4f0a\u9a6c\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u8fbe\u6c99\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e09\u3001\u5c3c\u6d1b\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u56db\u3001\u5409\u745e\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e94\u3001\u4f0a\u5e03\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516d\u3001\u8d1d\u6797\u59a5\u6b27\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e03\u3001\u7ef4\u5948\u514b\u62c9\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516b\u3001\u5229\u59a5\u6614\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e5d\u3001\u7ef4\u5e03\u59a5\u6614\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u3001\u897f\u8fbe\u672c\u80fa\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e00\u3001\u787c\u66ff\u4f50\u7c73\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e8c\u3001\u4fe1\u8fea\u5229\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e09\u3001<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u5361\u745e\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u56db\u3001\u66ff\u96f7\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e94\u3001\u6cfd\u5e03\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u516d\u3001\u6765\u90a3\u5ea6\u80fa\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e03\u3001\u6cca\u9a6c\u5ea6\u80fa\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u516b\u3001\u6c99\u5229\u5ea6\u80fa\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e5d\u3001\u4f0a\u6c99\u4f50\u7c73<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u3001\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e00\u3001\u82a6\u53ef\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\">\n\t\t<b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\">\u6ccc\u5c3f\u7cfb\u7edf\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n\t<\/p>\n<table class=\"MsoNormalTable ke-zeroborder\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"1063\" style=\"border-collapse:collapse;\">\n<tbody>\n<tr>\n<td width=\"1063\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e00\u3001\u4f9d\u7ef4\u83ab\u53f8\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1063\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u7d22\u62c9\u975e\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1063\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e09\u3001\u8212\u5c3c\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1063\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u56db\u3001\u963f\u6614\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1063\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e94\u3001\u57f9\u5511\u5e15\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516d\u3001\u4ed1\u4f10\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e03\u3001\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516b\u3001<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e5d\u3001\u66ff\u96f7\u5229\u73e0\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u3001\u7279\u745e\u666e\u5229\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u4e00\u3001\u5965\u62c9\u5e15\u5229\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\">\n\t\t<b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\">\u4e73\u817a\u764c\u7528\u836f<\/span><\/b><b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n\t<\/p>\n<table class=\"MsoNormalTable ke-zeroborder\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"1063\" style=\"border-collapse:collapse;\">\n<tbody>\n<tr>\n<td width=\"1063\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e00\u3001\u66f2\u59a5\u73e0\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u6069\u7f8e\u66f2\u59a5\u73e0\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e09\u3001\u5e15\u59a5\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u56db\u3001\u4f0a\u5c3c\u59a5\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1063\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e94\u3001\u62c9\u5e15\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516d\u3001\u5421\u54af\u66ff\u5c3c<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e03\u3001\u5948\u62c9\u66ff\u5c3c<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516b\u3001\u54cc\u67cf\u897f\u5229<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e5d\u3001\u963f\u8d1d\u897f\u5229\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u5341\u3001\u897f\u8fbe\u672c\u80fa\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\">\n\t\t<b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\">\u76ae\u80a4\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n\t<\/p>\n<table class=\"MsoNormalTable ke-zeroborder\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"1061\" style=\"border-collapse:collapse;\">\n<tbody>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e00\u3001\u4f0a\u9a6c\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u7ef4\u83ab\u975e\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e09\u3001\u8fbe\u62c9\u975e\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u56db\u3001\u66f2\u7f8e\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e94\u3001\u5e15\u535a\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516d\u3001\u7279\u745e\u666e\u5229\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\"> <\/span><\/b><b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\">\u9aa8\u4e0e\u8f6f\u7ec4\u7ec7\u80bf\u7624\u7528\u836f<span><\/span><\/span><\/b>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e00\u3001\u4f9d\u7ef4\u83ab\u53f8\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u5730\u8212\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"1061\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e09\u3001\u5b89\u7f57\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\">\n\t\t<b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\">\u5934\u9888\u90e8\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n\t<\/p>\n<table class=\"MsoNormalTable ke-zeroborder\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"1063\" style=\"border-collapse:collapse;\">\n<tbody>\n<tr>\n<td width=\"1063\" valign=\"top\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e00\u3001\u5c3c\u59a5\u73e0\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u7279\u745e\u666e\u5229\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e09\u3001\u5361\u745e\u5229\u73e0\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u56db\u3001\u7d22\u62c9\u975e\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e94\u3001\u4ed1\u4f10\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516d\u3001\u5b89\u7f57\u66ff\u5c3c\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e03\u3001\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u516b\u3001<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u897f\u59a5\u6614\u5355\u6297\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e5d\u3001\u5e15\u535a\u5229\u73e0\u5355\u6297<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:5.25pt;\">\n\t\t\t\t\t\t<b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\">\u751f\u6b96\u7cfb\u7edf\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e00\u3001\u5965\u62c9\u5e15\u5229\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e8c\u3001<\/span><span style=\"font-family:\u7b49\u7ebf;\">\u5c3c\u62c9\u5e15\u5229\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u4e09\u3001\u6c1f\u5511\u5e15\u5229\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u56db\u3001\u5e15\u7c73\u5e15\u5229\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<b><span style=\"font-family:\u7b49\u7ebf;\"> <\/span><\/b><b><span style=\"font-family:\u7b49\u7ebf;\">\u9644\u8868<span><\/span><\/span><\/b>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u9644\u8868<span>1<\/span>&emsp;\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u548c\u6cbb\u7597\u8c03\u6574\u65b9\u6848\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<span style=\"font-family:\u7b49\u7ebf;\">\u9644\u8868<span>2<\/span>&emsp;\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u5206\u7ea7\u6807\u51c6\u548c\u6cbb\u7597\u5efa\u8bae\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/span><span style=\"font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p><b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><br \/>\n<\/span><\/b> <\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t<b><span style=\"font-size:18.0pt;line-height:150%;font-family:;\" \"=\"\">\u7b2c\u4e00\u90e8\u5206&emsp;\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t<b><span style=\"font-size:18.0pt;line-height:150%;font-family:;\" \"=\"\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"> <\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u672c\u539f\u5219<span> <\/span><\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e3a\u89c4\u8303\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\uff0c\u63d0\u9ad8\u80bf\u7624\u6cbb\u7597\u7684\u5408\u7406\u7528\u836f\u6c34\u5e73\uff0c\u4fdd\u969c\u533b\u7597\u8d28\u91cf\u548c\u533b\u7597\u5b89\u5168\uff0c\u7ef4\u62a4\u80bf\u7624\u60a3\u8005\u5065\u5eb7\u6743\u76ca\uff0c\u7279\u5236\u5b9a\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219\u3002\u672c\u6307\u5bfc\u539f\u5219\u6d89\u53ca\u7684\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u662f\u6307\u5c0f\u5206\u5b50\u9776\u5411\u836f\u7269\u548c\u5927\u5206\u5b50\u5355\u514b\u9686\u6297\u4f53\u7c7b\u836f\u7269\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6297\u80bf\u7624\u836f\u7269\u7684\u5e94\u7528\u6d89\u53ca\u4e34\u5e8a\u591a\u4e2a\u5b66\u79d1\uff0c\u5408\u7406\u5e94\u7528\u6297\u80bf\u7624\u836f\u7269\u662f\u63d0\u9ad8\u7597\u6548\u3001\u964d\u4f4e\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u7387\u4ee5\u53ca\u5408\u7406\u5229\u7528\u536b\u751f\u8d44\u6e90\u7684\u5173\u952e\u3002\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u9700\u8003\u8651\u836f\u7269\u53ef\u53ca\u6027\u3001\u60a3\u8005\u6cbb\u7597\u610f\u613f\u548c\u75be\u75c5\u9884\u540e\u7b49\u4e09\u5927\u8981\u7d20\u3002\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u662f\u5426\u5408\u7406\uff0c\u57fa\u4e8e\u4ee5\u4e0b\u4e24\u65b9\u9762\uff1a\u6709\u65e0\u6297\u80bf\u7624\u836f\u7269\u5e94\u7528\u6307\u5f81\uff1b\u9009\u7528\u7684\u54c1\u79cd\u53ca\u7ed9\u836f\u65b9\u6848\u662f\u5426\u9002\u5b9c\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e00\u3001\u75c5\u7406\u7ec4\u7ec7\u5b66\u786e\u8bca\u540e\u65b9\u53ef\u4f7f\u7528<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53ea\u6709\u7ecf\u7ec4\u7ec7\u6216\u7ec6\u80de\u5b66\u75c5\u7406\u786e\u8bca\u3001\u6216\u7279\u6b8a\u5206\u5b50\u75c5\u7406\u8bca\u65ad\u6210\u7acb\u7684\u6076\u6027\u80bf\u7624\uff0c\u624d\u6709\u6307\u5f81\u4f7f\u7528\u6297\u80bf\u7624\u836f\u7269\u3002\u5355\u7eaf\u4f9d\u636e\u60a3\u8005\u7684\u4e34\u5e8a\u75c7\u72b6\u3001\u4f53\u5f81\u548c\u5f71\u50cf\u5b66\u7ed3\u679c\u5f97\u51fa\u4e34\u5e8a\u8bca\u65ad\u7684\u80bf\u7624\u60a3\u8005\uff0c\u6ca1\u6709\u6297\u80bf\u7624\u836f\u7269\u6cbb\u7597\u7684\u6307\u5f81\uff0c\u7ecf\u591a\u5b66\u79d1\u4f1a\u8bca\u4e0d\u9002\u5b9c\u624b\u672f\u6216\u6d3b\u68c0\u7684\u75c5\u4f8b\u9664\u5916\u3002\u4f46\u662f\uff0c\u5bf9\u4e8e\u67d0\u4e9b\u96be\u4ee5\u83b7\u53d6\u75c5\u7406\u8bca\u65ad\u7684\u80bf\u7624\uff0c\u5982\u80f0\u817a\u764c\u3001\u598a\u5a20\u6ecb\u517b\u7ec6\u80de\u80bf\u7624\u7b49\uff0c\u5176\u786e\u8bca\u53ef\u53c2\u7167\u56fd\u5bb6\u76f8\u5173\u6307\u5357\u6216\u89c4\u8303\u6267\u884c\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u9776\u70b9\u68c0\u6d4b\u540e\u65b9\u53ef\u4f7f\u7528<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u73b0\u4ee3\u6297\u80bf\u7624\u836f\u7269\u7684\u4e00\u4e2a\u663e\u8457\u7279\u5f81\uff0c\u662f\u51fa\u73b0\u4e00\u6279\u9488\u5bf9\u5206\u5b50\u5f02\u5e38\u7279\u5f81\u7684\u836f\u7269<span>\u2014\u2014<\/span>\u5373\u9776\u5411\u836f\u7269\u3002\u6700\u5177\u4ee3\u8868\u6027\u7684\u836f\u7269\u662f\u9488\u5bf9\u8868\u76ae\u751f\u957f\u56e0\u5b50\u4fe1\u53f7\u901a\u8def\u5f02\u5e38\u7684\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u3002\u76ee\u524d\uff0c\u6839\u636e\u662f\u5426\u9700\u8981\u505a\u9776\u70b9\u68c0\u6d4b\uff0c\u53ef\u4ee5\u5c06\u5e38\u7528\u7684\u5c0f\u5206\u5b50\u9776\u5411\u836f\u7269\u548c\u5927\u5206\u5b50\u5355\u514b\u9686\u6297\u4f53\u7c7b\u836f\u7269\u5206\u4e3a\u4e24\u5927\u7c7b\uff08\u8868<span>1<\/span>\uff09\u3002\u5177\u4f53\u7684\u68c0\u6d4b\u9776\u70b9\u8be6\u89c1\u5404\u7ae0\u8282\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8868<span>1 <\/span>\u5e38\u7528\u7684\u5c0f\u5206\u5b50\u9776\u5411\u836f\u7269\u548c\u5927\u5206\u5b50\u5355\u514b\u9686\u6297\u4f53\u7c7b\u836f\u7269<span><\/span><\/span><\/b>\n<\/p>\n<table class=\"MsoNormalTable\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"1195\" style=\"border-collapse:collapse;border:none;\">\n<tbody>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u75c5\u79cd<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9700\u8981\u68c0\u6d4b\u9776\u70b9\u7684\u836f\u7269<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u9700\u8981\u68c0\u6d4b\u9776\u70b9\u7684\u836f\u7269<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80ba\u764c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5409\u975e\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5384\u6d1b\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57c3\u514b\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u6cd5\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fbe\u53ef\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5965\u5e0c\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u7f8e\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0f\u7f8e\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u514b\u5511\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u6765\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u585e\u745e\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6069\u6c99\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u666e\u62c9\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d5b\u6c83\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u91cd\u7ec4\u4eba\u8840\u7ba1\u5185\u76ae\u6291\u5236\u7d20<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f9d\u7ef4\u83ab\u53f8<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297<sup><span>*<\/span><\/sup><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297<sup><span>*#<\/span><\/sup><span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5ea6\u4f10\u5229\u5c24\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u66ff\u5229\u73e0\u5355\u6297<sup><span>*#<\/span><\/sup><span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5361\u745e\u5229\u73e0\u5355\u6297<sup><span>*<\/span><\/sup><span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66ff\u96f7\u5229\u73e0\u5355\u6297<sup><span>*<\/span><\/sup><span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4fe1\u8fea\u5229\u5355\u6297<sup><span>*<\/span><\/sup><span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f8\u819c\u95f4\u76ae\u7624<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297<sup><span><\/span><\/sup><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u5339\u6728\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u809d\u764c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7d22\u62c9\u975e\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u745e\u6208\u975e\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4ed1\u4f10\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u591a\u7eb3\u975e\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u66ff\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4fe1\u8fea\u5229\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5361\u745e\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66ff\u96f7\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u98df\u7ba1\u764c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5361\u745e\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80c3\u764c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66f2\u59a5\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ef4\u8fea\u897f\u59a5\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u5e15\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80c3\u80a0\u95f4\u8d28\u7624<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u9a6c\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u4f10\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u745e\u6208\u975e\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8212\u5c3c\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u745e\u6d3e\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u795e\u7ecf\u5185\u5206\u6ccc\u7624<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8212\u5c3c\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f9d\u7ef4\u83ab\u53f8<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7d22\u51e1\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ed3\u76f4\u80a0\u764c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u897f\u59a5\u6614\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u745e\u6208\u975e\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u544b\u55b9\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u767d\u8840\u75c5<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u9a6c\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fbe\u6c99\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c3c\u6d1b\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5409\u745e\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u5e03\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u6797\u59a5\u6b27\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ef4\u5948\u514b\u62c9<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6dcb\u5df4\u7624<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5229\u59a5\u6614\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ef4\u5e03\u59a5\u6614\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u897f\u8fbe\u672c\u80fa<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u5e03\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u787c\u66ff\u4f50\u7c73<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4fe1\u8fea\u5229\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5361\u745e\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66ff\u96f7\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cfd\u5e03\u66ff\u5c3c<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u591a\u53d1\u6027\u9aa8\u9ad3\u7624<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u787c\u66ff\u4f50\u7c73<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6765\u90a3\u5ea6\u80fa<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cca\u9a6c\u5ea6\u80fa<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c99\u5229\u5ea6\u80fa<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u6c99\u4f50\u7c73<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fbe\u96f7\u59a5\u5c24\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9aa8\u9ad3\u589e\u6b96\u6027\u75be\u75c5<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u82a6\u53ef\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80be\u764c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f9d\u7ef4\u83ab\u53f8<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7d22\u62c9\u975e\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8212\u5c3c\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u6614\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57f9\u5511\u5e15\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4ed1\u4f10\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c3f\u8def\u4e0a\u76ae\u764c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66ff\u96f7\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7279\u745e\u666e\u5229\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u524d\u5217\u817a\u764c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5965\u62c9\u5e15\u5229<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e73\u817a\u764c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66f2\u59a5\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6069\u7f8e\u66f2\u59a5\u73e0\u5355\u6297<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;color:red;\"><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u59a5\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u5c3c\u59a5\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u62c9\u5e15\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5421\u54af\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5948\u62c9\u66ff\u5c3c<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;color:red;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u54cc\u67cf\u897f\u5229<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u8d1d\u897f\u5229<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u897f\u8fbe\u672c\u80fa<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9ed1\u8272\u7d20\u7624<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u9a6c\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ef4\u83ab\u975e\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fbe\u62c9\u975e\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66f2\u7f8e\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7279\u745e\u666e\u5229\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ed3\u8282\u6027\u786c\u5316\u75c7\u76f8\u5173\u7684\u5ba4\u7ba1\u819c\u4e0b\u5de8\u7ec6\u80de\u661f\u5f62\u7ec6\u80de\u7624<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f9d\u7ef4\u83ab\u53f8<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ed3\u8282\u6027\u786c\u5316\u75c7\u76f8\u5173\u7684\u80be\u8840\u7ba1\u5e73\u6ed1\u808c\u8102\u80aa\u7624<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f9d\u7ef4\u83ab\u53f8<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9aa8\u5de8\u7ec6\u80de\u7624<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5730\u8212\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u817a\u6ce1\u72b6\u8f6f\u7ec4\u7ec7\u8089\u7624<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u900f\u660e\u7ec6\u80de\u8089\u7624<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5176\u4ed6\u665a\u671f\u8f6f\u7ec4\u7ec7\u8089\u7624<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9f3b\u54bd\u764c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c3c\u59a5\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7279\u745e\u666e\u5229\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5361\u745e\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7532\u72b6\u817a\u764c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7d22\u62c9\u975e\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4ed1\u4f10\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u897f\u59a5\u6614\u5355\u6297<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5375\u5de2\u764c\uff08\u4e00\u7ebf\u7ef4\u6301\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5965\u62c9\u5e15\u5229<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c3c\u62c9\u5e15\u5229<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5375\u5de2\u764c\u3010\u94c2\u654f\u611f\u590d\u53d1\uff08<span>PSR<\/span>\uff09\u7ef4\u6301\u3011<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5965\u62c9\u5e15\u5229<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c3c\u62c9\u5e15\u5229<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c1f\u5511\u5e15\u5229<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"382\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5375\u5de2\u764c\uff08\u591a\u7ebf\u590d\u53d1\u6cbb\u7597\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"393\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c1f\u5511\u5e15\u5229<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u7c73\u5e15\u5229<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"420\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<sup><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">*<\/span><\/sup><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9700\u6392\u9664<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u548c<span>ALK<\/span>\u878d\u5408\u9633\u6027\u7684\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<sup><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">#<\/span><\/sup><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a\u5e15\u535a\u5229\u73e0\u5355\u6297\u5355\u836f\u4f7f\u7528\u3001<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u66ff\u5229\u73e0\u5355\u6297<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5355\u836f\u4f7f\u7528\u524d\u9700\u68c0\u6d4b<span>PD-L1<\/span>\u8868\u8fbe\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u660e\u786e\u4f5c\u7528\u9776\u70b9\u7684\u836f\u7269\uff0c\u987b\u9075\u5faa\u9776\u70b9\u68c0\u6d4b\u540e\u65b9\u53ef\u4f7f\u7528\u7684\u539f\u5219\u3002\u68c0\u6d4b\u6240\u7528\u7684\u4eea\u5668\u8bbe\u5907\u3001\u8bca\u65ad\u8bd5\u5242\u548c\u68c0\u6d4b\u65b9\u6cd5\u5e94\u5f53\u7ecf\u8fc7\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u90e8\u95e8\u6279\u51c6\uff0c\u7279\u522b\u662f\u7ecf\u8fc7\u4f34\u968f\u8bca\u65ad\u9a8c\u8bc1\u7684\u65b9\u6cd5\u3002\u4e0d\u5f97\u5728\u672a\u505a\u76f8\u5173\u68c0\u67e5\u7684\u60c5\u51b5\u4e0b\u76f2\u76ee\u7528\u836f\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e09\u3001\u4e25\u683c\u9075\u5faa\u9002\u5e94\u8bc1\u7528\u836f<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6297\u80bf\u7624\u836f\u7269\u7684\u836f\u54c1\u8bf4\u660e\u4e66\u662f\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u7684\u6cd5\u5b9a\u4f9d\u636e\uff0c\u5176\u89c4\u5b9a\u7684\u9002\u5e94\u8bc1\u7ecf\u8fc7\u4e86\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u90e8\u95e8\u6279\u51c6\u3002\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u987b\u9075\u5faa\u836f\u54c1\u8bf4\u660e\u4e66\uff0c\u4e0d\u80fd\u968f\u610f\u8d85\u9002\u5e94\u8bc1\u4f7f\u7528\u3002\u5728\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u8fc7\u7a0b\u4e2d\uff0c\u53d1\u73b0\u65b0\u7684\u5177\u6709\u9ad8\u7ea7\u522b\u5faa\u8bc1\u533b\u5b66\u8bc1\u636e\u7684\u7528\u6cd5\u4f46\u836f\u54c1\u8bf4\u660e\u4e66\u4e2d\u672a\u4f53\u73b0\u7684\uff0c\u533b\u7597\u673a\u6784\u548c\u533b\u52a1\u4eba\u5458\u53ef\u53ca\u65f6\u5411\u836f\u54c1\u751f\u4ea7\u5382\u5546\u53cd\u9988\uff0c\u5efa\u8bae\u5176\u4e3b\u52a8\u5411\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u90e8\u95e8\u7533\u62a5\uff0c\u53ca\u65f6\u66f4\u65b0\u76f8\u5e94\u836f\u54c1\u8bf4\u660e\u4e66\uff0c\u4ee5\u4fdd\u8bc1\u836f\u54c1\u8bf4\u660e\u4e66\u7684\u79d1\u5b66\u6027\u3001\u6743\u5a01\u6027\uff0c\u6709\u6548\u6307\u5bfc\u4e34\u5e8a\u7528\u836f\u3002\u7279\u522b\u662f\u6709\u6761\u4ef6\u5feb\u901f\u6279\u51c6\u4e0a\u5e02\u7684\u836f\u54c1\uff0c\u66f4\u5e94\u5f53\u4fdd\u8bc1\u836f\u54c1\u8bf4\u660e\u4e66\u7684\u65f6\u6548\u6027\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56db\u3001\u4f53\u73b0\u60a3\u8005\u6cbb\u7597\u4ef7\u503c<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u73b0\u4ee3\u4e34\u5e8a\u80bf\u7624\u5b66\u9ad8\u5ea6\u91cd\u89c6\u6076\u6027\u80bf\u7624\u60a3\u8005\u7684\u6cbb\u7597\u4ef7\u503c\u3002\u5176\u6838\u5fc3\u601d\u60f3\u662f\uff0c\u5728\u76f8\u540c\u6cbb\u7597\u6210\u672c\u524d\u63d0\u4e0b\uff0c\u4f7f\u60a3\u8005\u83b7\u5f97\u66f4\u957f\u7684\u751f\u5b58\u65f6\u95f4\u548c\u66f4\u597d\u7684\u751f\u6d3b\u8d28\u91cf\u3002\u5728\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u4e2d\uff0c\u5e94\u5f53\u5145\u5206\u8003\u8651\u6297\u80bf\u7624\u836f\u7269\u7684\u6210\u672c<span>&#8211;<\/span>\u6548\u679c\u6bd4\uff0c\u4f18\u5148\u9009\u62e9\u5177\u6709\u836f\u7269\u7ecf\u6d4e\u5b66\u8bc4\u4ef7\u4f18\u52bf\u8bc1\u636e\u7684\u54c1\u79cd\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e94\u3001\u7279\u6b8a\u60c5\u51b5\u4e0b\u7684\u836f\u7269\u5408\u7406\u4f7f\u7528<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u968f\u7740\u764c\u75c7\u6cbb\u7597\u4e34\u5e8a\u5b9e\u8df5\u7684\u5feb\u901f\u53d1\u5c55\uff0c\u76ee\u524d\u4e0a\u5e02\u7684\u6297\u80bf\u7624\u836f\u7269\u5c1a\u4e0d\u80fd\u5b8c\u5168\u6ee1\u8db3\u80bf\u7624\u60a3\u8005\u7684\u7528\u836f\u9700\u6c42\uff0c\u836f\u54c1\u8bf4\u660e\u4e66\u4e5f\u5f80\u5f80\u6ede\u540e\u4e8e\u4e34\u5e8a\u5b9e\u8df5\uff0c\u4e00\u4e9b\u5177\u6709\u9ad8\u7ea7\u522b\u5faa\u8bc1\u533b\u5b66\u8bc1\u636e\u7684\u7528\u6cd5\u672a\u80fd\u53ca\u65f6\u5728\u836f\u54c1\u8bf4\u660e\u4e66\u4e2d\u660e\u786e\u89c4\u5b9a\u3002\u5728\u5c1a\u65e0\u66f4\u597d\u6cbb\u7597\u624b\u6bb5\u7b49\u7279\u6b8a\u60c5\u51b5\u4e0b\uff0c\u533b\u7597\u673a\u6784\u5e94\u5f53\u5236\u5b9a\u76f8\u5e94\u7ba1\u7406\u5236\u5ea6\u3001\u6280\u672f\u89c4\u8303\uff0c\u5bf9\u836f\u54c1\u8bf4\u660e\u4e66\u4e2d\u672a\u660e\u786e\u3001\u4f46\u5177\u6709\u5faa\u8bc1\u533b\u5b66\u8bc1\u636e\u7684\u836f\u54c1\u7528\u6cd5\u8fdb\u884c\u4e25\u683c\u7ba1\u7406\u3002\u7279\u6b8a\u60c5\u51b5\u4e0b\u6297\u80bf\u7624\u836f\u7269\u7684\u4f7f\u7528\u6743\u5e94\u5f53\u4ec5\u9650\u4e8e\u4e09\u7ea7\u533b\u9662\u6388\u6743\u7684\u5177\u6709\u9ad8\u7ea7\u4e13\u4e1a\u6280\u672f\u804c\u79f0\u7684\u533b\u5e08\uff0c\u5145\u5206\u9075\u5faa\u60a3\u8005\u77e5\u60c5\u540c\u610f\u539f\u5219\uff0c\u5e76\u4e14\u5e94\u5f53\u505a\u597d\u7528\u836f\u76d1\u6d4b\u548c\u8ddf\u8e2a\u89c2\u5bdf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7279\u6b8a\u60c5\u51b5\u4e0b\u6297\u80bf\u7624\u836f\u7269\u5faa\u8bc1\u533b\u5b66\u8bc1\u636e\u91c7\u7eb3\u6839\u636e\u4f9d\u6b21\u662f\uff1a\u5176\u4ed6\u56fd\u5bb6\u6216\u5730\u533a\u836f\u54c1\u8bf4\u660e\u4e66\u4e2d\u5df2\u6ce8\u660e\u7684\u7528\u6cd5\uff0c\u56fd\u9645\u6743\u5a01\u5b66\u534f\u4f1a\u6216\u7ec4\u7ec7\u53d1\u5e03\u7684\u8bca\u7597\u89c4\u8303\u3001\u4e34\u5e8a\u8bca\u7597\u6307\u5357\uff0c\u56fd\u5bb6\u7ea7\u5b66\u534f\u4f1a\u53d1\u5e03\u7684\u7ecf\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u5458\u4f1a\u8ba4\u53ef\u7684\u8bca\u7597\u89c4\u8303\u3001\u4e34\u5e8a\u8bca\u7597\u6307\u5357\u548c\u4e34\u5e8a\u8def\u5f84\u7b49\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u516d\u3001\u91cd\u89c6\u836f\u7269\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6297\u80bf\u7624\u836f\u7269\u7684\u76f8\u5173\u6027\u6bd2\u526f\u4f5c\u7528\u53d1\u751f\u7387\u8f83\u9ad8\uff0c\u4e5f\u5bb9\u6613\u4ea7\u751f\u7f55\u89c1\u7684\u6bd2\u526f\u4f5c\u7528\uff0c\u56e0\u6b64\u6297\u80bf\u7624\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u62a5\u544a\u5c24\u4e3a\u91cd\u8981\u3002\u533b\u7597\u673a\u6784\u5e94\u5f53\u5efa\u7acb\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u3001\u836f\u54c1\u635f\u5bb3\u4e8b\u4ef6\u76d1\u6d4b\u62a5\u544a\u5236\u5ea6\uff0c\u5e76\u6309\u7167\u56fd\u5bb6\u6709\u5173\u89c4\u5b9a\u5411\u76f8\u5173\u90e8\u95e8\u62a5\u544a\u3002\u533b\u7597\u673a\u6784\u5e94\u5f53\u5c06\u6297\u80bf\u7624\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u62a5\u544a\u7eb3\u5165\u533b\u7597\u8d28\u91cf\u8003\u6838\u4f53\u7cfb\uff0c\u5b9a\u671f\u5206\u6790\u548c\u62a5\u544a\u6297\u80bf\u7624\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u7684\u52a8\u6001\u548c\u8d8b\u52bf\u3002\u4e34\u5e8a\u533b\u5e08\u548c\u4e34\u5e8a\u836f\u5e08\u5e94\u5f53\u5bc6\u5207\u968f\u8bbf\u60a3\u8005\u7684\u7528\u836f\u76f8\u5173\u6bd2\u6027\uff0c\u5e76\u53ca\u65f6\u4e0a\u62a5\u4e0d\u826f\u53cd\u5e94\uff0c\u5c24\u5176\u662f\u4e25\u91cd\u7684\u548c\u65b0\u53d1\u73b0\u7684\u4e0d\u826f\u53cd\u5e94\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p><b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><br \/>\n<\/span><\/b> <\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:36.0pt;\">\n\t<b><span style=\"font-size:18.0pt;line-height:150%;font-family:;\" \"=\"\">\u7b2c\u4e8c\u90e8\u5206&emsp;\u5404\u7cfb\u7edf\u80bf\u7624\u7684\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u547c\u5438\u7cfb\u7edf\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e00\u3001\u5409\u975e\u66ff\u5c3c<span> Gefitinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>250mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">EGFR<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff09\u57fa\u56e0\u5177\u6709\u654f\u611f\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08<span>NSCLC<\/span>\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08<span>NMPA<\/span>\uff09\u6279\u51c6\u7684<span>EGFR<\/span>\u57fa\u56e0\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230\u7684<span>EGFR<\/span>\u654f\u611f\u7a81\u53d8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80bf\u7624\u7ec4\u7ec7\u548c\u8840\u6db2\u5747\u53ef\u7528\u4e8e<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u68c0\u6d4b\uff0c\u4f46\u7ec4\u7ec7\u68c0\u6d4b\u4f18\u5148\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u6761\u6807\u51c6\u4e5f\u9002\u7528\u4e8e\u5176\u4ed6\u5c0f\u5206\u5b50\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u671f\u95f4\u56e0\u836f\u7269\u6bd2\u6027\u4e0d\u53ef\u8010\u53d7\u65f6\uff0c\u53ef\u5728\u540c\u4e00\u4ee3\u836f\u7269\u4e4b\u95f4\u66ff\u6362\uff0c\u5982\u75be\u75c5\u8fdb\u5c55\u5219\u4e0d\u80fd\u5728\u540c\u4e00\u4ee3\u836f\u7269\u4e4b\u95f4\u66ff\u6362\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u5f71\u50cf\u5b66\u663e\u793a\u7f13\u6162\u8fdb\u5c55\u4f46\u4e34\u5e8a\u75c7\u72b6\u672a\u53d1\u751f\u6076\u5316\u7684\u60a3\u8005\uff0c\u53ef\u4ee5\u7ee7\u7eed\u4f7f\u7528\u539f\u836f\u7269\uff1b\u663e\u793a\u5be1\u8fdb\u5c55\u6216\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u8fdb\u5c55\u60a3\u8005\uff0c\u53ef\u4ee5\u7ee7\u7eed\u4f7f\u7528\u539f\u836f\u7269\u52a0\u5c40\u90e8\u6cbb\u7597\uff1b\u5bf9\u4e8e\u5e7f\u6cdb\u8fdb\u5c55\u7684\u60a3\u8005\uff0c\u5efa\u8bae\u6539\u6362\u4e3a\u5176\u4ed6\u6cbb\u7597\u65b9\u6848\u3002\u672c\u6761\u6807\u51c6\u4e5f\u9002\u7528\u4e8e\u5176\u4ed6\u5c0f\u5206\u5b50\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u76ae\u80a4\u9ecf\u819c\u53cd\u5e94\u548c\u8179\u6cfb\uff1b\u5e94\u7279\u522b\u6ce8\u610f\u95f4\u8d28\u6027\u80ba\u708e\u3001\u809d\u810f\u6bd2\u6027\u548c\u773c\u90e8\u75c7\u72b6\u7684\u53d1\u751f\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u5242\u91cf\u8c03\u6574\uff1a\uff08<span>1<\/span>\uff09<span>CYP3A4<\/span>\u5f3a\u8bf1\u5bfc\u5242\uff1a\u5982\u679c\u672a\u51fa\u73b0\u91cd\u5ea6\u836f\u7269\u4e0d\u826f\u53cd\u5e94\uff0c\u5409\u975e\u66ff\u5c3c\u65e5\u5242\u91cf\u53ef\u589e\u52a0\u81f3<span>500mg<\/span>\uff0c\u4e2d\u6b62\u5f3a\u6548<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u7ed9\u836f\u540e<span>7<\/span>\u5929\uff0c\u91cd\u65b0\u5f00\u59cb\u5409\u975e\u66ff\u5c3c<span>250mg<\/span>\u7ed9\u836f\u3002\uff08<span>2<\/span>\uff09<span>CYP3A4<\/span>\u6291\u5236\u5242\uff1a\u5f3a\u6548<span>CYP3A4<\/span>\u6291\u5236\u5242\uff08\u5982\u916e\u5eb7\u5511\u548c\u4f0a\u66f2\u5eb7\u5511\uff09\u80fd\u964d\u4f4e\u5409\u975e\u66ff\u5c3c\u4ee3\u8c22\uff0c\u589e\u52a0\u5176\u8840\u6d46\u6d53\u5ea6\u3002\u5409\u975e\u66ff\u5c3c\u4e0e\u5f3a\u6548<span>CYP3A4<\/span>\u6291\u5236\u5242\u5408\u5e76\u7528\u836f\u65f6\uff0c\u5e94\u76d1\u6d4b\u4e0d\u826f\u53cd\u5e94\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u67d0\u4e9b\u80bf\u7624\u6025\u75c7\u7684\u60c5\u51b5\u4e0b\u5982\u8111\u8f6c\u79fb\u660f\u8ff7\u6216\u547c\u5438\u8870\u7aed\uff0c\u5728\u5145\u5206\u77e5\u60c5\u7684\u60c5\u51b5\u4e0b\uff0c\u5bf9\u4e0d\u5438\u70df\u7684\u80ba\u817a\u764c\u60a3\u8005\uff0c\u53ef\u8003\u8651\u5728\u9a71\u52a8\u57fa\u56e0\u4e0d\u660e\u7684\u60c5\u51b5\u4e0b\u5c3d\u5feb\u7528\u836f\u3002\u4e00\u65e6\u75c5\u60c5\u7f13\u89e3\uff0c\u5fc5\u987b\u8865\u5145\u8fdb\u884c<span>EGFR<\/span>\u7a81\u53d8\u7684\u7ec4\u7ec7\u6216\u8840\u6db2\u68c0\u6d4b\u3002\uff08\u672c\u6761\u6807\u51c6\u4e5f\u9002\u7528\u4e8e\u5176\u4ed6<span>EGFR<\/span>\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff09<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u5384\u6d1b\u66ff\u5c3c<span> Erlotinib<\/span><\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>100mg<\/span>\u3001<span>150mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">EGFR<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u56e0\u5177\u6709\u654f\u611f\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:21.0pt;\">\n<table cellpadding=\"0\" cellspacing=\"0\" width=\"100%\">\n<tbody>\n<tr>\n<td>\n<div>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t\t<span style=\"font-size:8.0pt;\"><\/span>\n\t\t\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t\t<span style=\"font-size:7.5pt;font-family:\u5b8b\u4f53;\">\u672c\u6307\u5bfc\u539f\u5219\u201c\u5408\u7406\u7528\u836f\u8981\u70b9\u201d\u5e26<b><sup>\u203b<\/sup><\/b>\u90e8\u5206\u4e3a\u7279\u6b8a\u60c5\u51b5\u4e0b\u589e\u52a0\u9002\u5e94\u8bc1\u7528\u836f\u4e13\u5bb6\u5171\u8bc6\u3002<\/span><span style=\"font-size:8.0pt;\"><\/span>\n\t\t\t\t\t\t<\/p>\n<\/p><\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"506\" height=\"55\" src=\"file:\/\/C:\/Users\/%E7%8E%8B%E8%B1%AB\/AppData\/Local\/Temp\/msohtmlclip1\/01\/clip_image002.png\" align=\"left\" alt=\"\u6587\u672c\u6846: \u672c\u6307\u5bfc\u539f\u5219\u201c\u5408\u7406\u7528\u836f\u8981\u70b9\u201d\u5e26\u203b\u90e8\u5206\u4e3a\u7279\u6b8a\u60c5\u51b5\u4e0b\u589e\u52a0\u9002\u5e94\u8bc1\u7528\u836f\u4e13\u5bb6\u5171\u8bc6\u3002 \" \/><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684<span>EGFR<\/span>\u57fa\u56e0\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230\u7684<span>EGFR<\/span>\u654f\u611f\u7a81\u53d8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u8111\u8f6c\u79fb\u7684<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u7684<span>NSCLC<\/span>\u60a3\u8005\u548c<span>21<\/span>\u5916\u663e\u5b50<span>L858R<\/span>\u7f6e\u6362\u7a81\u53d8\u9633\u6027\u665a\u671f<span>NSCLC<\/span>\u60a3\u8005\uff0c\u53ef\u9009\u62e9\u5384\u6d1b\u66ff\u5c3c\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5384\u6d1b\u66ff\u5c3c\u5355\u836f\u7528\u4e8e<span>NSCLC<\/span>\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>150mg\/d<\/span>\uff0c\u81f3\u5c11\u5728\u996d\u524d<span>1<\/span>\u5c0f\u65f6\u6216\u996d\u540e<span>2<\/span>\u5c0f\u65f6\u670d\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u76ae\u80a4\u9ecf\u819c\u53cd\u5e94\u548c\u8179\u6cfb\u3002\u5e94\u7279\u522b\u6ce8\u610f\u95f4\u8d28\u6027\u80ba\u708e\u3001\u809d\u529f\u80fd\u5f02\u5e38\u548c\u773c\u90e8\u75c7\u72b6\u7684\u53d1\u751f\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u4e0e<span>CYP3A4<\/span>\u5f3a\u6291\u5236\u5242\u6216\u5f3a\u8bf1\u5bfc\u5242\u8054\u5408\u4f7f\u7528\u3002\u907f\u514d\u5384\u6d1b\u66ff\u5c3c\u4e0e\u80fd\u663e\u8457\u4e14\u6301\u7eed\u5347\u9ad8\u80c3\u6db2<span>pH<\/span>\u503c\u7684\u836f\u7269\u5408\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5438\u70df\u4f1a\u5bfc\u81f4\u5384\u6d1b\u66ff\u5c3c\u7684\u66b4\u9732\u91cf\u964d\u4f4e\uff0c\u5efa\u8bae\u60a3\u8005\u6212\u70df\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7f8e\u56fd<span>FDA<\/span>\u6279\u51c6\u5384\u6d1b\u66ff\u5c3c\u4e0e\u5409\u897f\u4ed6\u6ee8\u8054\u5408\u7528\u4e8e\u5c40\u90e8\u665a\u671f\u3001\u65e0\u6cd5\u5207\u9664\u6216\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff0c\u76ee\u524d\u56fd\u5185\u5c1a\u672a\u83b7\u6279\u6b64\u9002\u5e94\u8bc1\uff0c\u53ef\u5728\u4e0e\u60a3\u8005\u5145\u5206\u6c9f\u901a\u7684\u60c5\u51b5\u4e0b\u4f7f\u7528\u3002\u7528\u6cd5\u4e3a<span>l00mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e09\u3001\u57c3\u514b\u66ff\u5c3c<span> Icotinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>125mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.EGFR<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u56e0\u5177\u6709\u654f\u611f\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2161\uff5e\u2162<span>A<\/span>\u671f\u4f34\u6709<span>EGFR<\/span>\u57fa\u56e0\u654f\u611f\u7a81\u53d8<span>NSCLC<\/span>\u7684\u672f\u540e\u8f85\u52a9\u6cbb\u7597\u3002 <span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684<span>EGFR<\/span>\u57fa\u56e0\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230\u7684<span>EGFR<\/span>\u654f\u611f\u7a81\u53d8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.EGFR<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u56e0\u654f\u611f\u7a81\u53d8\u7684\u2161\uff5e\u2162<span>A<\/span>\u671f<span>NSCLC<\/span>\u60a3\u8005\u5b8c\u5168\u80bf\u7624\u5207\u9664\u672f\u540e\u63a8\u8350\u57c3\u514b\u66ff\u5c3c\u8f85\u52a9\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e38\u89c4\u5242\u91cf\u662f<span>125mg<\/span><\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\/<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b21<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u6bcf\u5929\u4e09\u6b21\uff0c\u5bf9\u4e8e<span>21<\/span>\u5916\u663e\u5b50<span>L858R<\/span>\u7f6e\u6362\u7a81\u53d8\u9633\u6027\u665a\u671f<span>NSCLC<\/span>\u60a3\u8005\uff0c\u53ef\u4ee5\u4f7f\u7528<span>250mg<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\/<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b21<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u6bcf\u5929\u4e09\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u8111\u8f6c\u79fb\u7684<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u7684<span>NSCLC<\/span>\u60a3\u8005\uff0c\u53ef\u4f18\u5148\u9009\u62e9\u57c3\u514b\u66ff\u5c3c\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u826f\u53cd\u5e94\u4e3b\u8981\u4e3a\u5e38\u89c1\u7684<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>2<\/span>\u7ea7<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ae\u75b9\u548c\u8179\u6cfb\uff0c\u5e94\u7279\u522b\u5173\u6ce8\u95f4\u8d28\u6027\u80ba\u708e\u7684\u53d1\u751f\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57c3\u514b\u66ff\u5c3c\u4e3b\u8981\u901a\u8fc7<span>CYP450<\/span>\u7cfb\u7edf\u7684<span>CYP2C19<\/span>\u548c<span>CYP3A4<\/span>\u4ee3\u8c22\uff0c\u5bf9<span>CYP2C9<\/span>\u548c<span>CYP3A4<\/span>\u6709\u660e\u663e\u7684\u6291\u5236\u4f5c\u7528\uff0c\u4e0e\u4e0a\u8ff0\u4e24\u79cd\u4ee3\u8c22\u9176\u8bf1\u5bfc\u5242\u548c\u5e95\u7269\u836f\u7269\u5408\u7528\u65f6\u5e94\u6ce8\u610f\u6f5c\u5728\u7684\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56db\u3001\u963f\u6cd5\u66ff\u5c3c<span> Afatinib<\/span><\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>30mg<\/span>\u3001<span>40mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5177\u6709<span>EGFR<\/span>\u57fa\u56e0\u654f\u611f\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\uff0c\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7<span>EGFR<\/span>\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08<span>EGFR-TKI<\/span>\uff09\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u542b\u94c2\u5316\u7597\u671f\u95f4\u6216\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u9cde\u72b6\u7ec4\u7ec7\u5b66\u7c7b\u578b\u7684<span>NSCLC<\/span>\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e00\u7ebf\u6cbb\u7597<span>EGFR<\/span>\u57fa\u56e0\u654f\u611f\u7a81\u53d8\u7684\u665a\u671f<span>NSCLC<\/span>\u60a3\u8005\uff0c\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684<span>EGFR<\/span>\u57fa\u56e0\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230\u7684<span>EGFR<\/span>\u57fa\u56e0\u654f\u611f\u7a81\u53d8\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u867d\u7136\u836f\u54c1\u8bf4\u660e\u4e66\u663e\u793a\u963f\u6cd5\u66ff\u5c3c\u4e0d\u9700\u8fdb\u884c\u57fa\u56e0\u68c0\u6d4b\u53ef\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597\u542b\u94c2\u5316\u7597\u671f\u95f4\u6216\u5316\u7597\u540e\u8fdb\u5c55\u7684\u665a\u671f\u80ba\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\uff0c\u4f46\u4ecd\u7136\u4e0d\u63a8\u8350\u7528\u4e8e<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u7684\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u975e\u5e38\u89c1<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u60a3\u8005\uff0c\u4f18\u5148\u4f7f\u7528\u963f\u6cd5\u66ff\u5c3c\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a<span>40mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u53ef\u6839\u636e\u60a3\u8005\u8010\u53d7\u6027\u8fdb\u884c\u5242\u91cf\u8c03\u6574\uff0c\u5242\u91cf\u8c03\u6574\u65b9\u6848\u89c1\u8868<span>2<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8868<span>2 <\/span>\u963f\u6cd5\u66ff\u5c3c\u63a8\u8350\u5242\u91cf\u8c03\u6574\u65b9\u6848<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<div align=\"center\">\n<table class=\"MsoNormalTable\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"1123\" style=\"border-collapse:collapse;border:none;\">\n<tbody>\n<tr>\n<td width=\"461\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">CTCAE<\/span><\/b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">a<\/span><\/sup><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08<span>4.0<\/span>\u7248\uff09\u836f\u7269\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"661\" colspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u6cd5\u66ff\u5c3c\u7684\u5efa\u8bae\u7ed9\u836f\u91cf<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"461\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>2<\/span>\u7ea7<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"321\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u4e2d\u65ad<sup><span>b<\/span><\/sup><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"340\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u8c03\u6574\u5242\u91cf<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"461\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\uff08\u5ef6\u957f<sup><span>c<\/span><\/sup>\u6216\u4e0d\u8010\u53d7\uff09\u6216\u2265<span>3<\/span>\u7ea7<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"321\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e2d\u65ad\u76f4\u5230\u6062\u590d\u81f3<span>0\/1<\/span>\u7ea7<sup><span>b<\/span><\/sup><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"340\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4ee5\u51cf\u91cf<span>10mg<\/span>\u9012\u51cf\u7ee7\u7eed<sup><span>d<\/span><\/sup><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p class=\"MsoNormal\" style=\"margin-left:0cm;text-indent:28.0pt;\">\n\t<sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">a<\/span><\/sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7f8e\u56fd\u56fd\u7acb\u764c\u75c7\u7814\u7a76\u6240\uff08<span>NCI<\/span>\uff09\u4e0d\u826f\u4e8b\u4ef6\u901a\u7528\u672f\u8bed\u6807\u51c6<span>4.0<\/span>\u7248\u3002<\/span><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/sup>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">b<\/span><\/sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53d1\u751f\u8179\u6cfb\u65f6\uff0c\u5e94\u7acb\u5373\u4f7f\u7528\u6297\u8179\u6cfb\u836f\u7269\uff08\u5982\u6d1b\u54cc\u4e01\u80fa\uff09\uff0c\u5e76\u4e14\u5bf9\u4e8e\u6301\u7eed\u8179\u6cfb\u7684\u60c5\u51b5\u5e94\u7ee7\u7eed\u7528\u836f\u76f4\u5230\u8179\u6cfb\u505c\u6b62\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"margin-left:0cm;text-indent:28.0pt;\">\n\t<sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">c<\/span><\/sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8179\u6cfb\uff1e<span>48<\/span>\u5c0f\u65f6\u548c<span>\/<\/span>\u6216\u76ae\u75b9\uff1e<span>7<\/span>\u5929\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"margin-left:0cm;text-indent:28.0pt;\">\n\t<sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">d<\/span><\/sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u60a3\u8005\u4e0d\u80fd\u8010\u53d7\u6bcf\u5929<span>20mg<\/span>\uff0c\u5e94\u8003\u8651\u6c38\u4e45\u505c\u7528\u672c\u54c1\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u4e34\u5e8a\u533b\u751f\u8bc4\u4ef7\u4e3a\u8010\u53d7\u6027\u5dee\u7684\u60a3\u8005\uff0c\u53ef\u4f7f\u7528<span>30mg<\/span>\u4f5c\u4e3a\u63a8\u8350\u5242\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u6cd5\u66ff\u5c3c\u4e0d\u5e94\u4e0e\u98df\u7269\u540c\u670d\uff0c\u5e94\u5f53\u5728\u8fdb\u98df\u540e\u81f3\u5c11<span>3<\/span>\u5c0f\u65f6\u6216\u8fdb\u98df\u524d\u81f3\u5c11<span>1<\/span>\u5c0f\u65f6\u670d\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u8179\u6cfb\u3001\u76ae\u80a4\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\u3001\u95f4\u8d28\u6027\u80ba\u708e\u7b49\u4e0d\u826f\u4e8b\u4ef6\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u9700\u8981\u4f7f\u7528<span>P-<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\uff0c\u5e94\u91c7\u7528\u4ea4\u9519\u5242\u91cf\u7ed9\u836f\uff0c\u5c3d\u53ef\u80fd\u5ef6\u957f\u4e0e\u963f\u6cd5\u66ff\u5c3c\u7ed9\u836f\u7684\u95f4\u9694\u65f6\u95f4\u3002<span>P-<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\u5e94\u5728\u963f\u6cd5\u66ff\u5c3c\u7ed9\u836f\u540e\u95f4\u9694<span>6<\/span>\u5c0f\u65f6\uff08<span>P-<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\u6bcf\u5929\u4e24\u6b21\u7ed9\u836f\uff09\u6216<span>12<\/span>\u5c0f\u65f6\uff08<span>P-<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\u6bcf\u5929\u4e00\u6b21\u7ed9\u836f\uff09\u7ed9\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u6cd5\u66ff\u5c3c\u4e0d\u901a\u8fc7<span>CYP<\/span>\u9176\u7cfb\u4ee3\u8c22\uff0c\u4f53\u5916\u5b9e\u9a8c\u7814\u7a76\u663e\u793a\u4e0e<span>CYP<\/span>\u6291\u5236\u5242\u6216\u8bf1\u5bfc\u5242\u8054\u7528\u65f6\uff0c\u5bf9\u963f\u6cd5\u66ff\u5c3c\u7684\u66b4\u9732\u91cf\u65e0\u660e\u663e\u5f71\u54cd\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u542b\u6709\u4e73\u7cd6\uff0c\u60a3\u6709\u7f55\u89c1\u9057\u4f20\u6027\u534a\u4e73\u7cd6\u4e0d\u8010\u75c7\u3001\u4e73\u7cd6\u9176\u7f3a\u4e4f\u75c7\u6216\u8461\u8404\u7cd6<span>&#8211;<\/span>\u534a\u4e73\u7cd6\u5438\u6536\u4e0d\u826f\u7684\u60a3\u8005\u4e0d\u5e94\u670d\u7528\u6b64\u836f\u54c1\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e94\u3001\u8fbe\u53ef\u66ff\u5c3c<span> Dacomitinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>15mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5355\u836f\u7528\u4e8e<span>EGFR19<\/span>\u5916\u663e\u5b50\u7f3a\u5931\u7a81\u53d8\u6216<span>21<\/span>\u5916\u663e\u5b50<span>L858R<\/span>\u7f6e\u6362\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684<span>EGFR<\/span>\u57fa\u56e0\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230\u7684<span>EGFR19<\/span>\u5916\u663e\u5b50\u7f3a\u5931\u7a81\u53d8\u6216<span>21<\/span>\u5916\u663e\u5b50<span>L858R<\/span>\u7f6e\u6362\u7a81\u53d8\u9633\u6027\u7684\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e<span>21<\/span>\u5916\u663e\u5b50<span>L858R<\/span>\u7f6e\u6362\u7a81\u53d8\u9633\u6027\u60a3\u8005\uff0c\u4f18\u5148\u63a8\u8350\u8fbe\u53ef\u66ff\u5c3c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u60a3\u8005\u63a5\u53d7\u672c\u836f\u7269\u6cbb\u7597\u76f4\u5230\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u65e0\u6cd5\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a<span>45mg<\/span>\u53e3\u670d\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u53ef\u4e0e\u98df\u7269\u540c\u670d\uff0c\u4e5f\u53ef\u4e0d\u4e0e\u98df\u7269\u540c\u670d\u3002\u5bf9\u4e8e\u4e34\u5e8a\u533b\u751f\u8bc4\u4ef7\u4e3a\u8010\u53d7\u6027\u5dee\u7684\u5e74\u8001\u4f53\u5f31\u60a3\u8005\uff0c\u8d77\u59cb\u5242\u91cf\u53ef\u4ece<span>30mg<\/span>\u53e3\u670d\u3001\u6bcf\u5929\u4e00\u6b21\u5f00\u59cb\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6bcf\u5929\u5728\u5927\u81f4\u76f8\u540c\u7684\u65f6\u95f4\u670d\u7528\u672c\u54c1\u3002\u5982\u679c\u60a3\u8005\u5455\u5410\u6216\u6f0f\u670d\u4e00\u5242\uff0c\u4e0d\u5e94\u8ffd\u52a0\u5242\u91cf\u6216\u8865\u5145\u670d\u7528\u6f0f\u670d\u5242\u91cf\uff0c\u800c\u5e94\u5728\u4e0b\u4e00\u6b21\u7684\u670d\u836f\u65f6\u95f4\u670d\u7528\u89c4\u5b9a\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fbe\u53ef\u66ff\u5c3c\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u4e3a\u8179\u6cfb\u3001\u76ae\u75b9\u3001\u7532\u6c9f\u708e\u3001\u53e3\u8154\u9ecf\u819c\u708e\u3001\u76ae\u80a4\u5e72\u71e5\u7b49\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u7279\u522b\u5173\u6ce8\u95f4\u8d28\u6027\u80ba\u708e\u7684\u53d1\u751f\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u51fa\u73b0\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u6839\u636e\u60a3\u8005\u7684\u8010\u53d7\u6027\uff0c\u4ee5\u6bcf\u6b21\u51cf\u91cf<span>15mg<\/span>\u7684\u65b9\u5f0f\u9010\u6b65\u964d\u4f4e\u672c\u54c1\u7684\u5242\u91cf\uff1a\uff08<span>1<\/span>\uff09\u9996\u6b21\u51cf\u91cf\u81f3<span>30mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u3002\uff08<span>2<\/span>\uff09\u7b2c\u4e8c\u6b21\u51cf\u91cf\u81f3<span>15mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u3002\u5982\u679c\u60a3\u8005\u4e0d\u8010\u53d7<span>15mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u7684\u7ed9\u836f\u5242\u91cf\uff0c\u5e94\u8be5\u6c38\u4e45\u505c\u7528\u3002\u5728\u547c\u5438\u7cfb\u7edf\u75c7\u72b6\u6076\u5316\u4e14\u53ef\u80fd\u9884\u793a\u95f4\u8d28\u6027\u80ba\u708e\uff08\u4f8b\u5982\u547c\u5438\u56f0\u96be\u3001\u54b3\u55fd\u548c\u53d1\u70ed\uff09\u7684\u60a3\u8005\u4e2d\u6682\u65f6\u505c\u7528\u672c\u54c1\u5e76\u7acb\u5373\u8fdb\u884c\u95f4\u8d28\u6027\u80ba\u708e\u7684\u8bca\u65ad\u3002\u5982\u679c\u786e\u8bca\u4e3a\u4efb\u4f55\u7ea7\u522b\u7684\u95f4\u8d28\u6027\u80ba\u708e\uff0c\u5219\u6c38\u4e45\u505c\u7528\u672c\u54c1\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u5efa\u8bae\u5bf9\u8f7b\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u6216\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u7684\u60a3\u8005\u8c03\u6574\u5242\u91cf\u3002\u5c1a\u672a\u786e\u5b9a\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u672c\u54c1\u63a8\u8350\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u670d\u7528\u672c\u54c1\u65f6\uff0c\u907f\u514d\u540c\u65f6\u4f7f\u7528\u8d28\u5b50\u6cf5\u6291\u5236\u5242\u3002\u53ef\u4f7f\u7528\u5c40\u90e8\u4f5c\u7528\u7684\u6297\u9178\u5242\u6216<span>H<sub>2<\/sub><\/span>\u53d7\u4f53\u62ee\u6297\u5242\u4ee3\u66ff\u8d28\u5b50\u6cf5\u6291\u5236\u5242\uff1b\u5fc5\u987b\u4e34\u65f6\u670d\u7528<span>H<sub>2<\/sub><\/span>\u53d7\u4f53\u62ee\u6297\u5242\u7684\u60c5\u51b5\u4e0b\uff0c\u81f3\u5c11\u63d0\u524d<span>6<\/span>\u5c0f\u65f6\u6216\u6ede\u540e<span>10<\/span>\u5c0f\u65f6\u540e\u7ed9\u4e88\u672c\u54c1\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u670d\u7528\u672c\u54c1\u65f6\uff0c\u907f\u514d\u540c\u65f6\u4f7f\u7528<span>CYP2D6<\/span>\u5e95\u7269\uff0c\u56e0\u4e3a<span>CYP2D6<\/span>\u5e95\u7269\u6d53\u5ea6\u7565\u5fae\u589e\u52a0\u53ef\u80fd\u4ea7\u751f\u4e25\u91cd\u7684\u6216\u5371\u53ca\u751f\u547d\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u516d\u3001<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5965\u5e0c\u66ff\u5c3c<span> Osimertinib<\/span><\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>40mg<\/span>\u3001<span>80mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u2160<span>B<\/span>\uff5e\u2162<span>A<\/span>\u671f<span>EGFR<\/span>\u57fa\u56e0\u5916\u663e\u5b50<span>19<\/span>\u7f3a\u5931\u6216<span>21<\/span>\u5916\u663e\u5b50<span>L858R<\/span>\u7f6e\u6362\u7a81\u53d8\u7684<span>NSCLC<\/span>\u60a3\u8005\u7684\u672f\u540e\u8f85\u52a9\u6cbb\u7597\uff0c\u5e76\u7531\u533b\u751f\u51b3\u5b9a\u63a5\u53d7\u6216\u4e0d\u63a5\u53d7\u8f85\u52a9\u5316\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5177\u6709<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">EGFR19<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5916\u663e\u5b50\u7f3a\u5931\u7a81\u53d8\u6216<span>21<\/span>\u5916\u663e\u5b50<span>L858R<\/span>\u7f6e\u6362\u7a81\u53d8<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u6210\u4eba\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u7ecf<span>EGFR-TKI<\/span>\u6cbb\u7597\u65f6\u6216\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\uff0c\u5e76\u4e14\u7ecf\u68c0\u6d4b\u786e\u8ba4\u5b58\u5728<span>EGFR-T790M<\/span>\u7a81\u53d8\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u6210\u4eba\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672f\u540e\u8f85\u52a9\u7528\u836f\u6216\u4e00\u7ebf\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684<span>EGFR<\/span>\u57fa\u56e0\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230\u7684<span>EGFR19<\/span>\u5916\u663e\u5b50\u7f3a\u5931\u7a81\u53d8\u6216<span>21<\/span>\u5916\u663e\u5b50<span>L858R<\/span>\u7f6e\u6362\u7a81\u53d8\u9633\u6027\u7684\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u65e2\u5f80\u7ecf<span>EGFR-TKI<\/span>\u6cbb\u7597\u65f6\u6216\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u60a3\u8005\uff0c\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230<span>EGFR-T790M<\/span>\u7a81\u53d8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.EGFR<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u56e0\u654f\u611f\u7a81\u53d8\u7684\u2160<span>B<\/span>\uff5e<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2162<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">A<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u671f<span>NSCLC<\/span>\u60a3\u8005\u5b8c\u5168\u80bf\u7624\u5207\u9664\u672f\u540e\u63a8\u8350<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5965\u5e0c\u66ff\u5c3c<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f85\u52a9\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.EGFR<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7a81\u53d8\u9633\u6027\u7684\u8111\u8f6c\u79fb\u6216\u8111\u819c\u8f6c\u79fb\u60a3\u8005\u63a8\u8350\u4f18\u5148\u4f7f\u7528\u5965\u5e0c\u66ff\u5c3c\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5965\u5e0c\u66ff\u5c3c\u63a8\u8350\u5242\u91cf\u4e3a<span>80mg<\/span>\u53e3\u670d\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u8fdb\u9910\u6216\u7a7a\u8179\u65f6\u670d\u7528\u5747\u53ef\u3002\u6839\u636e\u60a3\u8005\u4e2a\u4f53\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u6682\u505c\u7528\u836f\u6216\u51cf\u91cf\u3002\u5982\u679c\u9700\u8981\u51cf\u91cf\uff0c\u5219\u5242\u91cf\u5e94\u51cf\u81f3<span>40mg<\/span>\u53e3\u670d\uff0c\u6bcf\u5929\u4e00\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u76ae\u80a4\u53cd\u5e94\u548c\u8179\u6cfb\uff0c\u9700\u6ce8\u610f\u5fc3\u7535\u56fe<span>QTc<\/span>\u95f4\u671f\u5ef6\u957f\uff0c\u5e94\u7279\u522b\u6ce8\u610f\u95f4\u8d28\u6027\u80ba\u708e\u7684\u53d1\u751f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u4e0e<span>CYP3A4<\/span>\u5f3a\u8bf1\u5bfc\u5242\u3001\u4e73\u817a\u764c\u8010\u836f\u86cb\u767d\u5e95\u7269\u4ee5\u53ca<span>P-<\/span>\u7cd6\u86cb\u767d\u5e95\u7269\u8054\u5408\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e03<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u3001\u963f\u7f8e\u66ff\u5c3c<span> Almonertinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>55mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u7ecf<span>EGFR-TKI<\/span>\u6cbb\u7597\u65f6\u6216\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\uff0c\u5e76\u4e14\u7ecf\u68c0\u6d4b\u786e\u8ba4\u5b58\u5728<span>EGFR-T790M<\/span>\u7a81\u53d8\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u6210\u4eba\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u7f8e\u66ff\u5c3c\u63a8\u8350\u5242\u91cf\u4e3a<span>110mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u53e3\u670d\uff0c\u7a7a\u8179\u6216\u9910\u540e\u670d\u7528\u5747\u53ef\uff0c\u6574\u7247\u541e\u670d\uff0c\u4e0d\u8981\u5480\u56bc\u6216\u538b\u788e\u3002\u5bf9\u4e8e\u65e0\u6cd5\u6574\u7247\u541e\u54bd\u836f\u7269\u548c\u9700\u7ecf\u9f3b\u80c3\u7ba1\u5582\u9972\u7684\u60a3\u8005\uff0c\u53ef\u5c06\u836f\u7247\u76f4\u63a5\u6eb6\u4e8e\u4e0d\u542b\u78b3\u9178\u76d0\u7684\u996e\u7528\u6c34\u4e2d\u5b8c\u5168\u5206\u6563\u540e\u670d\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230<span>EGFR-T790M<\/span>\u7a81\u53d8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u7f8e\u66ff\u5c3c\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u4e3a\u76ae\u75b9\u3001\u8840\u808c\u9178\u78f7\u9178\u6fc0\u9176\u5347\u9ad8\u548c\u7619\u75d2\u7b49\uff0c\u8179\u6cfb\u7684\u53d1\u751f\u7387\u76f8\u5bf9\u8f83\u4f4e\u3002\u63a8\u8350\u5242\u91cf\u4e0b\u8fc4\u4eca\u65e0\u95f4\u8d28\u6027\u80ba\u708e\u7684\u53d1\u751f\uff0c\u4f46\u4ecd\u9700\u5728\u670d\u836f\u671f\u95f4\u6ce8\u610f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u4e0e<span>CYP3A4<\/span>\u5f3a\u8bf1\u5bfc\u5242\u548c\u5f3a\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\uff0c\u5e94\u614e\u7528\u4e73\u817a\u764c\u8010\u836f\u86cb\u767d\u548c<span>P-<\/span>\u7cd6\u86cb\u767d\u654f\u611f\u5e95\u7269\u7684\u7a84\u6cbb\u7597\u7a97\u836f\u7269\u3002\u907f\u514d\u4e0e\u5347\u9ad8\u8840\u808c\u9178\u78f7\u9178\u6fc0\u9176\u7684\u836f\u7269\uff08\u5982\u4ed6\u6c40\u7c7b\u836f\u7269\uff09\u8054\u5408\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u516b\u3001\u4f0f\u7f8e\u66ff\u5c3c<span> Furmonertinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff0c<span>40mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u7ecf<span>EGFR-TKI<\/span>\u6cbb\u7597\u65f6\u6216\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\uff0c\u5e76\u4e14\u7ecf\u68c0\u6d4b\u786e\u8ba4\u5b58\u5728<span>EGFR-T790M<\/span>\u7a81\u53d8\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u6210\u4eba\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230<span>EGFR-T790M<\/span>\u7a81\u53d8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a<span>80mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u7a7a\u8179\u53e3\u670d\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0f\u7f8e\u66ff\u5c3c\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u4e3a\u4e19\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08<span>ALT<\/span>\uff09\u548c<span>\/<\/span>\u6216\u5929\u95e8\u51ac\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08<span>AST<\/span>\uff09\u5347\u9ad8\u3001\u5fc3\u7535\u56fe<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">QTc<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u95f4\u671f\u5ef6\u957f\u3002\u9700\u8b66\u60d5\u95f4\u8d28\u6027\u80ba\u708e\u7684\u53d1\u751f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u4e0e<span>CYP3A4<\/span>\u5f3a\u8bf1\u5bfc\u5242\u6216\u5f3a\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e5d\u3001<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u514b\u5511\u66ff\u5c3c<span> Crizotinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>200mg<\/span>\u3001<span>250mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08<span>ALK<\/span>\uff09\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.ROS1<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9633\u6027\u7684\u665a\u671f<span>NSCLC<\/span>\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230\u7684<span>ROS1<\/span>\u9633\u6027\u6216\u8005<span>ALK<\/span>\u9633\u6027\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u809d\u529f\u80fd\u5f02\u5e38\u548c\u89c6\u89c9\u5f02\u5e38\uff0c\u5728\u6cbb\u7597\u5f00\u59cb\u7684\u6700\u521d\u4e24\u4e2a\u6708\u5e94\u6bcf\u5468\u68c0\u6d4b\u4e00\u6b21\uff0c\u4e4b\u540e\u6bcf\u6708\u68c0\u6d4b\u4e00\u6b21\u60a3\u8005\u7684\u809d\u529f\u80fd\uff0c\u809d\u635f\u4f24\u60a3\u8005\u5e94\u8c28\u614e\u4f7f\u7528\u514b\u5511\u66ff\u5c3c\u8fdb\u884c\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a<span>250mg<\/span>\u53e3\u670d\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u4e0e\u98df\u7269\u540c\u670d\u6216\u4e0d\u540c\u670d\u3002\u5982\u679c\u51fa\u73b0<span>CTCAE<\/span>\uff08<span>4.0<\/span>\u7248\uff09<span>3<\/span>\u7ea7\u6216<span>4<\/span>\u7ea7\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0c\u9700\u6309\u4ee5\u4e0b\u65b9\u6cd5\u51cf\u5c11\u5242\u91cf\uff1a\uff08<span>1<\/span>\uff09\u7b2c\u4e00\u6b21\u51cf\u5c11\u5242\u91cf\uff1a\u53e3\u670d\uff0c<span>200mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u3002\uff08<span>2<\/span>\uff09\u7b2c\u4e8c\u6b21\u51cf\u5c11\u5242\u91cf\uff1a\u53e3\u670d\uff0c<span>250mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff1b\u5982\u679c\u6bcf\u5929\u4e00\u6b21\u53e3\u670d<span>250mg<\/span>\u514b\u5511\u66ff\u5c3c\u80f6\u56ca\u4ecd\u65e0\u6cd5\u8010\u53d7\uff0c\u5219\u6c38\u4e45\u505c\u670d\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u907f\u514d\u5408\u5e76\u4f7f\u7528<span>CYP3A<\/span>\u5f3a\u6291\u5236\u5242\u6216<span>CYP3A<\/span>\u5f3a\u8bf1\u5bfc\u5242\uff0c\u5982\u679c\u65e0\u6cd5\u907f\u514d\u5408\u5e76\u4f7f\u7528<span>CYP3A<\/span>\u5f3a\u6291\u5236\u5242\uff0c\u5e94\u51cf\u5c11\u514b\u5511\u66ff\u5c3c\u7684\u5242\u91cf\u3002\u5e94\u8c28\u614e\u4e0e\u4e2d\u5ea6<span>CYP3A<\/span>\u6291\u5236\u5242\u5408\u5e76\u7528\u836f\u3002\u514b\u5511\u66ff\u5c3c\u80f6\u56ca\u53ef\u5ef6\u957f<span>QTc<\/span>\u95f4\u671f\uff0c\u907f\u514d\u5408\u5e76\u4f7f\u7528\u53ef\u5ef6\u957f<span>QTc<\/span>\u95f4\u671f\u7684\u836f\u7269\u3002\u514b\u5511\u66ff\u5c3c\u80f6\u56ca\u53ef\u5f15\u8d77\u5fc3\u52a8\u8fc7\u7f13\uff0c\u907f\u514d\u5408\u5e76\u4f7f\u7528\u53ef\u5f15\u8d77\u5fc3\u52a8\u8fc7\u7f13\u7684\u836f\u7269\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u4e8e<span>Profile1001<\/span>\u7814\u7a76\u7ed3\u679c\u548c<span>2021<\/span>\u7248<span>NCCN<\/span>\u6307\u5357\uff0c\u514b\u5511\u66ff\u5c3c\u9002\u7528\u4e8e<span>cMET14<\/span>\u5916\u663e\u5b50\u8df3\u8dc3\u7a81\u53d8\u7684\u665a\u671f<span>NSCLC<\/span>\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5341\u3001\u963f\u6765\u66ff\u5c3c<span> Alectinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>150mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">ALK<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u60a3\u8005\u7528\u836f\u524d\u5fc5\u987b\u83b7\u5f97\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u8bc1\u5b9e\u7684<span>ALK<\/span>\u9633\u6027\u7ed3\u679c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u60a3\u8005\u63a5\u53d7\u672c\u836f\u7269\u6cbb\u7597\u76f4\u5230\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u65e0\u6cd5\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a<span>600mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u968f\u9910\u53e3\u670d\u3002\u5982\u51fa\u73b0\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5e94\u6839\u636e\u60a3\u8005\u8010\u53d7\u6027\uff0c\u4ee5\u6bcf\u6b21\u51cf\u91cf<span>150mg<\/span>\u7684\u65b9\u5f0f\u9010\u6b65\u964d\u4f4e\u672c\u54c1\u7684\u5242\u91cf\uff1a\uff08<span>1<\/span>\uff09\u9996\u6b21\u51cf\u91cf\uff1a<span>450mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u3002\uff08<span>2<\/span>\uff09\u7b2c\u4e8c\u6b21\u51cf\u91cf\uff1a<span>300mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\uff1b\u5982\u679c\u60a3\u8005\u4e0d\u80fd\u8010\u53d7<span>300mg<\/span>\u6bcf\u5929\u4e24\u6b21\u7684\u7ed9\u836f\u5242\u91cf\uff0c\u5e94\u8be5\u6c38\u4e45\u505c\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u57fa\u7ebf\u65f6\u5e94\u76d1\u6d4b\u809d\u529f\u80fd\uff0c\u5305\u62ec<span>ALT<\/span>\u3001<span>AST<\/span>\u548c\u603b\u80c6\u7ea2\u7d20\uff0c\u5728\u6700\u521d\u6cbb\u7597\u7684<span>3<\/span>\u4e2a\u6708\u5185\u6bcf\u4e24\u5468\u76d1\u6d4b\u4e00\u6b21\uff0c\u4e4b\u540e\u5b9a\u671f\u8fdb\u884c\u76d1\u6d4b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u60a3\u8005\u62a5\u544a\u4efb\u4f55\u539f\u56e0\u4e0d\u660e\u7684\u808c\u75db\u3001\u89e6\u75db\u6216\u865a\u5f31\uff0c\u8bc4\u4f30\u808c\u9178\u78f7\u9178\u6fc0\u9176\u6c34\u5e73\uff0c\u5728\u7b2c\u4e00\u4e2a\u6708\u6cbb\u7597\u671f\u95f4\u6bcf\u4e24\u5468\u8bc4\u4f30\u4e00\u6b21\uff0c\u968f\u540e\u5728\u4e34\u5e8a\u4e0a\u6839\u636e\u60a3\u8005\u62a5\u544a\u7684\u75c7\u72b6\u6309\u9700\u8fdb\u884c\u8bc4\u4f30\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u786e\u8bca\u60a3\u6709\u95f4\u8d28\u6027\u80ba\u708e<span>\/<\/span>\u975e\u611f\u67d3\u6027\u80ba\u708e\u7684\u60a3\u8005\u5e94\u7acb\u5373\u4e2d\u65ad\u672c\u54c1\u6cbb\u7597\uff0c\u5982\u679c\u6ca1\u6709\u53d1\u73b0\u5176\u4ed6\u95f4\u8d28\u6027\u80ba\u708e<span>\/<\/span>\u975e\u611f\u67d3\u6027\u80ba\u708e\u7684\u6f5c\u5728\u75c5\u56e0\uff0c\u5219\u5e94\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5728\u670d\u7528\u963f\u6765\u66ff\u5c3c\u65f6\u53ca\u6cbb\u7597\u505c\u6b62\u540e\u81f3\u5c11<span>7<\/span>\u5929\u5185\uff0c\u5e94\u5efa\u8bae\u60a3\u8005\u907f\u514d\u957f\u65f6\u95f4\u9633\u5149\u66b4\u6652\u3002\u6b64\u5916\uff0c\u5e94\u5efa\u8bae\u60a3\u8005\u4f7f\u7528\u9632\u7d2b\u5916\u7ebf<span>A<\/span>\uff08<span>UVA<\/span>\uff09<span>\/<\/span>\u7d2b\u5916\u7ebf<span>B<\/span>\uff08<span>UVB<\/span>\uff09\u7684\u5e7f\u8c31\u9632\u6652\u971c\u548c\u6da6\u5507\u818f\uff08<span>SPF<\/span>\u2265<span>50<\/span>\uff09\uff0c\u9632\u6b62\u53ef\u80fd\u7684\u6652\u4f24\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5e94\u6839\u636e\u4e34\u5e8a\u6307\u5f81\u76d1\u6d4b\u5fc3\u7387\u548c\u8840\u538b\u3002\u5982\u679c\u53d1\u751f\u65e0\u75c7\u72b6\u5fc3\u52a8\u8fc7\u7f13\uff0c\u5219\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff1b\u5982\u679c\u60a3\u8005\u53d1\u751f\u75c7\u72b6\u6027\u5fc3\u52a8\u8fc7\u7f13\u6216\u5371\u53ca\u751f\u547d\u7684\u4e8b\u4ef6\uff0c\u5e94\u5bf9\u5408\u5e76\u7528\u836f\u4e2d\u5df2\u77e5\u5f15\u53d1\u5fc3\u52a8\u8fc7\u7f13\u7684\u836f\u7269\uff08\u5982\u964d\u538b\u836f\uff09\u8fdb\u884c\u8bc4\u4f30\uff0c\u5e76\u4f9d\u636e\u8bf4\u660e\u4e66\u8c03\u6574\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5f53\u963f\u6765\u66ff\u5c3c\u4e0e\u6cbb\u7597\u6307\u6570\u72ed\u7a84\u7684<span>P-<\/span>\u7cd6\u86cb\u767d\u6216\u4e73\u817a\u764c\u8010\u836f\u86cb\u767d\u5e95\u7269\uff08\u5982\u5730\u9ad8\u8f9b\u3001\u8fbe\u6bd4\u52a0\u7fa4\u3001\u7532\u6c28\u8776\u5464\uff09\u5408\u5e76\u7528\u836f\u65f6\uff0c\u5efa\u8bae\u8fdb\u884c\u9002\u5f53\u7684\u76d1\u6d4b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u963f\u6765\u66ff\u5c3c\u4e0e<span>CYP3A<\/span>\u8bf1\u5bfc\u5242\u6216\u6291\u5236\u5242\u5408\u5e76\u7528\u836f\u65f6\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e00\u3001\u585e\u745e\u66ff\u5c3c<span> Ceritinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>150mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">ALK<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230\u7684<span>ALK<\/span>\u9633\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u7684\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u5929\u4e00\u6b21\uff0c<span>450mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u5728\u540c\u4e00\u65f6\u95f4\u53e3\u670d\u7ed9\u836f\uff0c\u836f\u7269\u5e94\u4e0e\u98df\u7269\u540c\u65f6\u670d\u7528\u3002\u6839\u636e\u60a3\u8005\u4e2a\u4f53\u7684\u5b89\u5168\u6027\u6216\u8010\u53d7\u6027\uff0c\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u53ef\u80fd\u9700\u8981\u6682\u65f6\u4e2d\u65ad\u4f7f\u7528\u672c\u54c1\u6216\u4e0b\u8c03\u5242\u91cf\uff0c\u5e94\u4ee5<span>150mg<\/span>\u7684\u4e0b\u8c03\u5e45\u5ea6\u9010\u6e10\u51cf\u5c11\u672c\u54c1\u7684\u65e5\u5242\u91cf\u3002\u5e94\u6ce8\u610f\u65e9\u671f\u8bc6\u522b\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u5e76\u53ca\u65e9\u7ed9\u4e88\u6807\u51c6\u7684\u652f\u6301\u6027\u6cbb\u7597\u63aa\u65bd\u3002\u5bf9\u4e8e\u65e0\u6cd5\u8010\u53d7\u6bcf\u5929\u968f\u9910\u670d\u7528<span>150mg<\/span>\u5242\u91cf\u7684\u60a3\u8005\uff0c\u5e94\u505c\u7528\u672c\u54c1\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u987b\u6ce8\u610f\u80c3\u80a0\u9053\u4e0d\u826f\u53cd\u5e94\u3001\u809d\u6bd2\u6027\u3001\u95f4\u8d28\u6027\u80ba\u708e<span>\/<\/span>\u975e\u611f\u67d3\u6027\u80ba\u708e\u3001\u5fc3\u5f8b\u5931\u5e38\u3001\u9ad8\u8840\u7cd6\u7b49\u4e0d\u826f\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u5e94\u907f\u514d\u8054\u5408\u4f7f\u7528\u5f3a\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\u3002\u5982\u679c\u5fc5\u987b\u540c\u65f6\u4f7f\u7528\u5f3a\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\uff08\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u5229\u6258\u90a3\u97e6\u3001\u6c99\u594e\u90a3\u97e6\u3001\u6cf0\u5229\u9709\u7d20\u3001\u916e\u5eb7\u5511\u3001\u4f0a\u66f2\u5eb7\u5511\u3001\u4f0f\u7acb\u5eb7\u5511\u3001\u6cca\u6c99\u5eb7\u5511\u3001\u5948\u6cd5\u5511\u916e\uff09\u65e0\u6cd5\u907f\u514d\uff0c\u5219\u5e94\u5c06\u585e\u745e\u66ff\u5c3c\u7684\u5242\u91cf\u51cf\u5c11\u7ea6\u4e09\u5206\u4e4b\u4e00\uff0c\u5e76\u8fd1\u4f3c\u4e3a<span>150mg<\/span>\u5242\u91cf\u89c4\u683c\u7684\u500d\u6570\u3002\u5f53\u505c\u6b62\u7ed9\u4e88<span>CYP3A<\/span>\u6291\u5236\u5242\u540e\uff0c\u6062\u590d\u4f7f\u7528\u5f3a<span>CYP3A<\/span>\u6291\u5236\u5242\u4e4b\u524d\u7684\u7ed9\u836f\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f53\u5916\u7814\u7a76\u6570\u636e\u663e\u793a\uff0c\u672c\u54c1\u662f\u5916\u6392\u578b\u8f6c\u8fd0\u86cb\u767d<span>P-<\/span>\u7cd6\u86cb\u767d\u7684\u5e95\u7269\u3002\u5982\u679c\u672c\u54c1\u4e0e\u6291\u5236<span>P-<\/span>\u7cd6\u86cb\u767d\u7684\u836f\u7269\u8054\u5408\u4f7f\u7528\uff0c\u53ef\u80fd\u5bfc\u81f4\u672c\u54c1\u6d53\u5ea6\u5347\u9ad8\u3002\u8054\u5408\u4f7f\u7528<span>P-<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\u65f6\u5e94\u8c28\u614e\uff0c\u5e76\u5c0f\u5fc3\u76d1\u6d4b\u4e0d\u826f\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u4e8e\u4e00\u9879\u53d1\u8868\u4e8e<span>JCO<\/span>\u7684\u2161\u671f\u4e34\u5e8a\u7814\u7a76\uff08<span>NCT01964157<\/span>\uff09\uff0c\u5728\u7ecf\u5316\u7597\u6cbb\u7597\u540e\u7684<span>ROS1<\/span>\u91cd\u6392\u7684<span>NSCLC<\/span>\u60a3\u8005\u53ef\u9009\u62e9\u585e\u745e\u66ff\u5c3c\u8fdb\u884c\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e8c\u3001\u6069\u6c99\u66ff\u5c3c <span>Ensartinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u786c\u80f6\u56ca\u5242\uff1a<span>25mg<\/span>\u3001<span>100mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u6b64\u524d\u63a5\u53d7\u8fc7\u514b\u5511\u66ff\u5c3c\u6cbb\u7597\u540e\u8fdb\u5c55\u7684\u6216\u8005\u5bf9\u514b\u5511\u66ff\u5c3c\u4e0d\u8010\u53d7\u7684<span>ALK<\/span>\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230\u7684<span>ALK<\/span>\u9633\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u5929\u4e00\u6b21\uff0c\u6bcf\u6b21<span>225mg<\/span>\uff0c\u6bcf\u5929\u5728\u540c\u4e00\u65f6\u95f4\u53e3\u670d\u7ed9\u836f\uff0c\u7a7a\u8179\u6216\u4e0e\u98df\u7269\u540c\u670d\u3002\u5982\u679c\u6f0f\u670d<span>1<\/span>\u6b21\uff0c\u4e14\u8ddd\u4e0b\u6b21\u670d\u836f\u65f6\u95f4\u95f4\u9694<span>12<\/span>\u5c0f\u65f6\u4ee5\u4e0a\uff0c\u60a3\u8005\u5e94\u8865\u670d\u6f0f\u670d\u7684\u5242\u91cf\u3002\u82e5\u6cbb\u7597\u671f\u95f4\u53d1\u751f\u5455\u5410\uff0c\u60a3\u8005\u4e0d\u5e94\u670d\u7528\u989d\u5916\u5242\u91cf\uff0c\u4f46\u5e94\u7ee7\u7eed\u670d\u7528\u4e0b\u6b21\u8ba1\u5212\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u82e5\u672c\u54c1\u5e94\u7528\u4e2d\u51fa\u73b0<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u9700\u8981\u8c03\u6574\u5242\u91cf\u53ef\u53c2\u8003\u5982\u4e0b\u539f\u5219\uff1a\u672c\u54c1\u8d77\u59cb\u5242\u91cf\u4e3a<span>225mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff1b\u9996\u6b21\u51cf\u91cf\u8c03\u6574\u4e3a<span>200mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff1b\u82e5\u4ecd\u4e0d\u80fd\u8010\u53d7\uff0c\u518d\u4e00\u6b21\u51cf\u91cf\u8c03\u6574\u4e3a<span>150mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff1b<span>150mg<\/span>\u6bcf\u5929\u4e00\u6b21\u4ecd\u65e0\u6cd5\u8010\u53d7\uff0c\u5e94\u505c\u7528\u672c\u54c1\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u4e3b\u8981\u4e0d\u826f\u53cd\u5e94\u4e3a\u4e00\u8fc7\u6027\u836f\u75b9\uff0c\u4e3b\u8981\u8868\u73b0\u4e3a<span>1<\/span>\uff5e<span>2<\/span>\u7ea7\u76ae\u75b9\u548c\u7619\u75d2\u75c7\uff0c\u60a3\u8005\u53d1\u751f\u76ae\u75b9\u4e2d\u4f4d\u6301\u7eed\u65f6\u95f4\u4e3a<span>21.5<\/span>\u5929\u3002\u9664\u76ae\u75b9\u5916\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u4e3a<span>1<\/span>\uff5e<span>2<\/span>\u7ea7<span>ALT\/AST<\/span>\u5347\u9ad8\uff0c\u4ee5\u53ca<span>1<\/span>\uff5e<span>2<\/span>\u7ea7\u80c3\u80a0\u9053\u4e0d\u9002\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u4e0e<span>CYP3A4<\/span>\u5f3a\u8bf1\u5bfc\u5242\u6216\u5f3a\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e09\u3001<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297<span> Bevacizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>4ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408\u4ee5\u94c2\u7c7b\u4e3a\u57fa\u7840\u7684\u5316\u7597\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u7684\u665a\u671f\u3001\u8f6c\u79fb\u6027\u6216\u590d\u53d1\u6027\u975e\u9cde\u72b6\u7ec6\u80de<span>NSCLC<\/span>\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297\u4e0d\u9002\u7528\u4e8e\u665a\u671f\u80ba\u9cde\u72b6\u7ec6\u80de\u764c\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u4e25\u91cd\u51fa\u8840\u6216\u8005\u8fd1\u671f\u66fe\u6709\u54af\u8840\u3001\u80bf\u7624\u4fb5\u72af\u5927\u8840\u7ba1\u7684\u60a3\u8005\u4e0d\u5e94\u63a5\u53d7\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408\u4ee5\u94c2\u7c7b\u4e3a\u57fa\u7840\u7684\u5316\u7597\u6700\u591a<span>6<\/span>\u4e2a\u5468\u671f\uff0c\u968f\u540e\u7ed9\u4e88\u8d1d\u4f10\u73e0\u5355\u6297\u5355\u836f\u7ef4\u6301\u6cbb\u7597\u6216\u4e0e\u53ef\u7528\u4e8e\u7ef4\u6301\u6cbb\u7597\u7684\u5316\u7597\u836f\u7269\u5982\u57f9\u7f8e\u66f2\u585e\u8054\u5408\u7ef4\u6301\u6cbb\u7597\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297\u63a8\u8350\u5242\u91cf\u4e3a<span>15mg\/kg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\u3002\u4e5f\u53ef\u4ee5\u4f7f\u7528<span>7.5mg\/kg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51fa\u73b0\u4ee5\u4e0b\u60c5\u51b5\uff0c\u505c\u6b62\u4f7f\u7528\u8d1d\u4f10\u73e0\u5355\u6297\uff1a<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08<span>1<\/span>\uff09<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e25\u91cd\u80c3\u80a0\u9053\u4e0d\u826f\u53cd\u5e94\uff08\u80c3\u80a0\u9053\u7a7f\u5b54\u3001\u80c3\u80a0\u9053\u7618\u5f62\u6210\u3001\u8179\u8154\u8113\u80bf\uff09\uff0c\u5185\u810f\u7618\u5f62\u6210\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08<span>2<\/span>\uff09<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9700\u8981\u5e72\u9884\u6cbb\u7597\u7684\u4f24\u53e3\u88c2\u5f00\u4ee5\u53ca\u4f24\u53e3\u6108\u5408\u5e76\u53d1\u75c7\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08<span>3<\/span>\uff09<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u91cd\u5ea6\u51fa\u8840\uff08\u4f8b\u5982\u9700\u8981\u5e72\u9884\u6cbb\u7597\uff09<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u3002\uff08<span>4<\/span>\uff09<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u91cd\u5ea6\u52a8\u8109\u8840\u6813\u4e8b\u4ef6\u3002\uff08<span>5<\/span>\uff09\u5371\u53ca\u751f\u547d\uff08<span>4<\/span>\u7ea7\uff09\u7684\u9759\u8109\u8840\u6813\u6813\u585e\u4e8b\u4ef6\uff0c\u5305\u62ec\u80ba\u6813\u585e\u3002\uff08<span>6<\/span>\uff09\u9ad8\u8840\u538b\u5371\u8c61\u6216\u9ad8\u8840\u538b\u8111\u75c5\u3002\uff08<span>7<\/span>\uff09\u53ef\u9006\u6027\u540e\u90e8\u8111\u75c5\u7efc\u5408\u5f81\u3002\uff08<span>8<\/span>\uff09\u80be\u75c5\u7efc\u5408\u5f81\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u51fa\u73b0\u4ee5\u4e0b\u72b6\u51b5\uff0c\u9700\u6682\u505c\u4f7f\u7528\u8d1d\u4f10\u73e0\u5355\u6297\uff1a\uff08<span>1<\/span>\uff09\u62e9\u671f\u624b\u672f\u524d<span>4<\/span>\uff5e<span>6<\/span>\u5468\uff0c\u624b\u672f\u540e\u81f3\u5c11<span>28<\/span>\u5929\u53ca\u4f24\u53e3\u5b8c\u5168\u6062\u590d\u4e4b\u524d\u3002\uff08<span>2<\/span>\uff09\u836f\u7269\u63a7\u5236\u4e0d\u826f\u7684\u91cd\u5ea6\u9ad8\u8840\u538b\u3002\uff08<span>3<\/span>\uff09\u4e2d\u5ea6\u5230\u91cd\u5ea6\u7684\u86cb\u767d\u5c3f\u9700\u8981\u8fdb\u4e00\u6b65\u8bc4\u4f30\u3002\uff08<span>4<\/span>\uff09\u91cd\u5ea6\u8f93\u6db2\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u6b27\u76df\uff0c\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408\u5384\u6d1b\u66ff\u5c3c\u83b7\u6279\u7528\u4e8e<span>EGFR<\/span>\u57fa\u56e0\u5177\u6709\u654f\u611f\u7a81\u53d8\u7684\u3001\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u665a\u671f\u3001\u8f6c\u79fb\u6027\u6216\u590d\u53d1\u6027\u975e\u9cde\u72b6<span>NSCLC<\/span>\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\uff0c\u76ee\u524d\u56fd\u5185\u5c1a\u672a\u83b7\u6279\u6b64\u9002\u5e94\u8bc1\uff0c\u53ef\u5728\u4e0e\u60a3\u8005\u5145\u5206\u6c9f\u901a\u7684\u60c5\u51b5\u4e0b\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u56db\u3001\u91cd\u7ec4\u4eba\u8840\u7ba1\u5185\u76ae\u6291\u5236\u7d20<span> Endostatin<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9488\u5242\uff1a<span>15mg<\/span>\uff08<span>3ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u8054\u5408\u957f\u6625\u745e\u6ee8<span>\/<\/span>\u987a\u94c2\uff08<span>NP<\/span>\uff09\u5316\u7597\u65b9\u6848\u7528\u4e8e\u6cbb\u7597\u521d\u6cbb\u6216\u590d\u6cbb\u7684\u2162\uff5e\u2163\u671f<span>NSCLC<\/span>\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u91cd\u7ec4\u4eba\u8840\u7ba1\u5185\u76ae\u6291\u5236\u7d20\u4e0e<span>NP<\/span>\u65b9\u6848\u8054\u5408\u81f3<span>4<\/span>\u4e2a\u5468\u671f\uff0c\u7136\u540e\u91c7\u7528\u672c\u54c1\u8fdb\u884c\u7ef4\u6301\u6cbb\u7597\u3002\u672c\u54c1\u9002\u7528\u4e8e\u521d\u6cbb\u6216\u590d\u6cbb\u7684\u2162\uff5e\u2163\u671f<span>NSCLC<\/span>\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u51fa\u73b0\u4ee5\u4e0b\u72b6\u51b5\uff0c\u9700\u6682\u505c\u4f7f\u7528\u91cd\u7ec4\u4eba\u8840\u7ba1\u5185\u76ae\u6291\u5236\u7d20\uff1a\uff08<span>1<\/span>\uff09\u51fa\u73b0\u76f8\u5173\u5fc3\u810f\u6bd2\u6027\u53cd\u5e94\u65f6\uff0c\u5982\u2265<span>3<\/span>\u7ea7\u6216\u2264<span>2<\/span>\u7ea7\u4e14\u6bd2\u6027\u53cd\u5e94\u6301\u7eed\u5b58\u5728\u3002\uff08<span>2<\/span>\uff09\u2265<span>3<\/span>\u7ea7\u76ae\u80a4\u8fc7\u654f\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u91cd\u7ec4\u4eba\u8840\u7ba1\u5185\u76ae\u6291\u5236\u7d20\u4e3b\u8981\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\uff1a\u57fa\u4e8e\u2163\u671f\u7814\u7a76\u7ed3\u679c\uff0c\u53d1\u751f\u7387\u5206\u522b\u4e3a\uff1a\u5fc3\u5f8b\u5931\u5e38\uff08<span>0.7%<\/span>\uff09\u3001\u5fc3\u529f\u80fd\u4e0b\u964d\uff08<span>0.2%<\/span>\uff09\u3001\u51fa\u8840\uff08<span>0.4%<\/span>\uff09\u3001\u8fc7\u654f\u53cd\u5e94\uff08<span>0.2%<\/span>\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fc7\u654f\u4f53\u8d28\u6216\u5bf9\u86cb\u767d\u7c7b\u751f\u7269\u5236\u54c1\u6709\u8fc7\u654f\u53f2\u8005\u614e\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u4e25\u91cd\u5fc3\u810f\u75c5\u6216\u75c5\u53f2\u8005\u614e\u7528\uff0c\u672c\u54c1\u4e34\u5e8a\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u5e94\u5b9a\u671f\u68c0\u6d4b\u5fc3\u7535\u56fe\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e94\u3001<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c<span> Anlotinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>8mg<\/span>\u3001<span>10mg<\/span>\u3001<span>12mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5355\u836f\u9002\u7528\u4e8e\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7<span>2<\/span>\u79cd\u7cfb\u7edf\u5316\u7597\u540e\u51fa\u73b0\u8fdb\u5c55\u6216\u590d\u53d1\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u60a3\u8005\u7684\u6cbb\u7597\u3002\u5bf9\u4e8e\u5b58\u5728<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u6216<span>ALK<\/span>\u9633\u6027\u7684\u60a3\u8005\uff0c\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u5e94\u63a5\u53d7\u76f8\u5e94\u7684\u9776\u5411\u836f\u7269\u6cbb\u7597\u540e\u8fdb\u5c55\u3001\u4e14\u81f3\u5c11\u63a5\u53d7\u8fc7<span>2<\/span>\u79cd\u7cfb\u7edf\u5316\u7597\u540e\u51fa\u73b0\u8fdb\u5c55\u6216\u590d\u53d1\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5355\u836f\u9002\u7528\u4e8e\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7<span>2<\/span>\u79cd\u5316\u7597\u65b9\u6848\u6cbb\u7597\u540e\u8fdb\u5c55\u6216\u590d\u53d1\u7684\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f7f\u7528\u5b89\u7f57\u66ff\u5c3c\u524d\u65e0\u9700\u8fdb\u884c\u57fa\u56e0\u68c0\u6d4b\uff0c\u4f46\u5bf9\u4e8e\u5b58\u5728<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u6216<span>ALK<\/span>\u878d\u5408\u9633\u6027\u7684\u60a3\u8005\uff0c\u5728\u5f00\u59cb\u5b89\u7f57\u66ff\u5c3c\u6cbb\u7597\u524d\u5e94\u63a5\u53d7\u76f8\u5e94\u7684\u6807\u51c6\u9776\u5411\u836f\u7269\u6cbb\u7597\u540e\u8fdb\u5c55\u3001\u4e14\u81f3\u5c11\u63a5\u53d7\u8fc7<span>2<\/span>\u79cd\u7cfb\u7edf\u5316\u7597\u540e\u51fa\u73b0\u8fdb\u5c55\u6216\u590d\u53d1\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e2d\u592e\u578b\u80ba\u9cde\u72b6\u7ec6\u80de\u764c\u6216\u5177\u6709\u5927\u54af\u8840\u98ce\u9669\u7684\u60a3\u8005\u3001\u91cd\u5ea6\u809d\u80be\u529f\u80fd\u635f\u4f24\u7684\u60a3\u8005\u7981\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c\u6709\u589e\u52a0\u53d1\u751f\u51fa\u8840\u4e8b\u4ef6\u548c\u53d1\u751f\u8840\u6813<span>\/<\/span>\u6813\u585e\u4e8b\u4ef6\u7684\u98ce\u9669\uff0c\u56e0\u6b64\uff0c\u5177\u6709\u51fa\u8840\u98ce\u9669\u3001\u51dd\u8840\u529f\u80fd\u5f02\u5e38\u7684\u60a3\u8005\u3001\u5177\u6709\u8840\u6813<span>\/<\/span>\u5352\u4e2d\u75c5\u53f2\u7684\u60a3\u8005\u4ee5\u53ca\u670d\u7528\u6297\u51dd\u836f\u7269\u53ca\u76f8\u5173\u75be\u75c5\u7684\u60a3\u8005\u5e94\u614e\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u6b21<span>12mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u65e9\u9910\u524d\u53e3\u670d\uff0c\u8fde\u7eed\u670d\u836f<span>2<\/span>\u5468\uff0c\u505c\u836f<span>1<\/span>\u5468\uff0c\u5373<span>3<\/span>\u5468\u4e3a\u4e00\u4e2a\u7597\u7a0b\u3002\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u8981\u5bc6\u5207\u76d1\u6d4b\u4e0d\u826f\u53cd\u5e94\uff0c\u5e76\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7a0b\u5ea6\uff0c\u5728\u533b\u5e08\u6307\u5bfc\u4e0b\u8c03\u6574\u5242\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5e94\u5bc6\u5207\u5173\u6ce8\u9ad8\u8840\u538b\u7684\u53d1\u751f\uff0c\u5e38\u89c4\u964d\u538b\u836f\u7269\u53ef\u6709\u6548\u63a7\u5236\u60a3\u8005\u8840\u538b\uff0c\u5982\u567b\u55ea\u7c7b\u5229\u5c3f\u5242\uff0c\u8840\u7ba1\u7d27\u5f20\u7d20\u8f6c\u6362\u9176\u6291\u5236\u5242\uff08<span>ACEI<\/span>\uff09\u7b49\uff08\u9274\u4e8e\u836f\u7269\u76f8\u4e92\u4f5c\u7528\uff0c\u5bf9<span>ACEI<\/span>\u7c7b\u4e0d\u80fd\u63a7\u5236\u7684\u9ad8\u8840\u538b\u53ef\u914c\u60c5\u9009\u62e9\u9499\u79bb\u5b50\u62ee\u6297\u5242\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u4e0e<span>CYP1A2<\/span>\u548c<span>CYP3A4<\/span>\u7684\u5f3a\u6291\u5236\u5242\u548c\u5f3a\u8bf1\u5bfc\u5242\u8054\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5341\u516d\u3001\u4f9d\u7ef4\u83ab\u53f8<span>Everolimus<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>2.5mg<\/span>\u3001<span>5mg<\/span>\u3001<span>10mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u65e0\u6cd5\u624b\u672f\u5207\u9664\u7684\u3001\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u7684\u3001\u5206\u5316\u826f\u597d\u7684\u3001\u8fdb\u5c55\u671f\u975e\u529f\u80fd\u6027\u80c3\u80a0\u9053\u6216\u80ba\u6e90\u795e\u7ecf\u5185\u5206\u6ccc\u7624\u6210\u4eba\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>10mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u53e3\u670d\u7ed9\u836f\uff0c\u5728\u6bcf\u5929\u540c\u4e00\u65f6\u95f4\u670d\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u7528\u4e00\u676f\u6c34\u6574\u7247\u9001\u670d\u672c\u54c1\u7247\u5242\uff0c\u4e0d\u5e94\u5480\u56bc\u6216\u538b\u788e\u3002\u5bf9\u4e8e\u65e0\u6cd5\u541e\u54bd\u7247\u5242\u7684\u60a3\u8005\uff0c\u7528\u836f\u524d\u5c06\u672c\u54c1\u7247\u5242\u653e\u5165\u4e00\u676f\u6c34\u4e2d\uff08\u7ea6<span>30ml<\/span>\uff09\u8f7b\u8f7b\u6405\u62cc\u81f3\u5b8c\u5168\u6eb6\u89e3\uff08\u5927\u7ea6\u9700\u8981<span>7<\/span>\u5206\u949f\uff09\u540e\u7acb\u5373\u670d\u7528\u3002\u7528\u76f8\u540c\u5bb9\u91cf\u7684\u6c34\u6e05\u6d17\u6c34\u676f\u5e76\u5c06\u6e05\u6d17\u6db2\u5168\u90e8\u670d\u7528\uff0c\u4ee5\u786e\u4fdd\u670d\u7528\u4e86\u5b8c\u6574\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u53ea\u8981\u5b58\u5728\u4e34\u5e8a\u83b7\u76ca\u5c31\u5e94\u6301\u7eed\u6cbb\u7597\uff0c\u6216\u4f7f\u7528\u81f3\u51fa\u73b0\u4e0d\u80fd\u8010\u53d7\u7684\u6bd2\u6027\u53cd\u5e94\u65f6\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5728\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u6ca1\u6709\u8fdb\u884c\u672c\u54c1\u7684\u4e34\u5e8a\u7814\u7a76\u3002\u9884\u671f\u80be\u529f\u80fd\u635f\u4f24\u4e0d\u4f1a\u5f71\u54cd\u836f\u7269\u66b4\u9732\uff0c\u5728\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u4e0d\u63a8\u8350\u8c03\u6574\u4f9d\u7ef4\u83ab\u53f8\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5177\u6709\u514d\u75ab\u6291\u5236\u6027\uff0c\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u5e94\u5f7b\u5e95\u6cbb\u7597\u5df2\u7ecf\u5b58\u5728\u7684\u4fb5\u5165\u6027\u771f\u83cc\u611f\u67d3\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5bf9\u672c\u54c1\u6709\u6548\u6210\u5206\u3001\u5176\u4ed6\u96f7\u5e15\u9709\u7d20\u884d\u751f\u7269\u6216\u672c\u54c1\u4e2d\u4efb\u4f55\u8f85\u6599\u8fc7\u654f\u8005\u7981\u7528\u3002\u5728\u4f7f\u7528\u4f9d\u7ef4\u83ab\u53f8\u548c\u5176\u4ed6\u96f7\u5e15\u9709\u7d20\u884d\u751f\u7269\u60a3\u8005\u4e2d\u5df2\u89c2\u5bdf\u5230\u7684\u8fc7\u654f\u53cd\u5e94\u8868\u73b0\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\uff1a\u8fc7\u654f\u3001\u547c\u5438\u56f0\u96be\u3001\u6f6e\u7ea2\u3001\u80f8\u75db\u6216\u8840\u7ba1\u6027\u6c34\u80bf\uff08\u4f8b\u5982\uff0c\u4f34\u6216\u4e0d\u4f34\u547c\u5438\u529f\u80fd\u4e0d\u5168\u7684\u6c14\u9053\u6216\u820c\u80bf\u80c0\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u53e3\u8154\u708e\u5305\u62ec\u53e3\u8154\u6e83\u75a1\u548c\u53e3\u8154\u9ecf\u819c\u708e\u3002\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u53d1\u751f\u7387\u4e3a<span>44%<\/span>\uff5e<span>86%<\/span>\uff0c<span>4%<\/span>\uff5e<span>9%<\/span>\u7684\u60a3\u8005\u62a5\u544a\u4e86<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u53e3\u8154\u708e\u3002\u53e3\u8154\u708e\u5927\u90e8\u5206\u5728\u6cbb\u7597\u7684\u524d<span>8<\/span>\u5468\u5185\u53d1\u751f\u3002\u5982\u679c\u53d1\u751f\u53e3\u8154\u708e\uff0c\u5efa\u8bae\u4f7f\u7528\u5c40\u90e8\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u907f\u514d\u8054\u7528<span>CYP3A4<\/span>\u5f3a\u6548\u6291\u5236\u5242\u548c\u8bf1\u5bfc\u5242\u4ee5\u53ca<span>P-<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\u3002\u5408\u7528\u4e2d\u6548<span>CYP3A4<\/span>\u548c<span>\/<\/span>\u6216<span>P-<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\u5e94\u5c06\u4f9d\u7ef4\u83ab\u53f8\u5242\u91cf\u964d\u4f4e\u5927\u7ea6<span>50%<\/span>\uff1b\u5982\u9700\u4f7f\u7528\u5f3a<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u7684\u5ba4\u7ba1\u819c\u4e0b\u5de8\u7ec6\u80de\u661f\u5f62\u7ec6\u80de\u7624\u60a3\u8005\u5728\u5f00\u59cb\u6cbb\u7597\u65f6\u53ef\u80fd\u9700\u8981\u589e\u52a0\u672c\u54c1\u7684\u5242\u91cf\u4ee5\u8fbe\u5230\u8c37\u6d53\u5ea6<span>5<\/span>\uff5e<span>15ng\/ml<\/span>\u3002\u5c06\u672c\u54c1\u7684\u65e5\u5242\u91cf\u7ffb\u500d\u5e76\u8bc4\u4f30\u8010\u53d7\u6027\u3002\u5728\u5242\u91cf\u7ffb\u500d\u7684\u5927\u7ea6<span>2<\/span>\u5468\u540e\u8bc4\u4f30\u4f9d\u7ef4\u83ab\u53f8\u8c37\u6d53\u5ea6\u3002\u5fc5\u8981\u65f6\u6309\u589e\u5e45<span>1<\/span>\uff5e<span>4mg<\/span>\u8fdb\u4e00\u6b65\u8c03\u6574\u5242\u91cf\u4ee5\u7ef4\u6301\u8c37\u6d53\u5ea6\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e03\u3001\u666e\u62c9\u66ff\u5c3c<span> Pralsetinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>100mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u63a5\u53d7\u8fc7\u542b\u94c2\u5316\u7597\u7684\u8f6c\u67d3\u91cd\u6392\uff08<span>RET<\/span>\uff09\u57fa\u56e0\u878d\u5408\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u6210\u4eba\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u524d\u5fc5\u987b\u660e\u786e\u6709\u7ecf\u5145\u5206\u9a8c\u8bc1\u7684\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230<span>RET<\/span>\u57fa\u56e0\u878d\u5408\u9633\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u5929<span>400mg<\/span>\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u65e0\u6cd5\u8010\u53d7\u7684\u6bd2\u6027\u3002\u5e94\u5728\u6bcf\u5929\u76f8\u540c\u7684\u65f6\u95f4\u670d\u7528\uff0c\u7a7a\u8179\u72b6\u6001\u4e0b\u53e3\u670d\uff0c\u5373\u670d\u7528\u672c\u54c1\u524d\u81f3\u5c11<span>2<\/span>\u5c0f\u65f6\u4ee5\u53ca\u670d\u7528\u672c\u54c1\u540e\u81f3\u5c11<span>1<\/span>\u5c0f\u65f6\u8bf7\u52ff\u8fdb\u98df\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u6f0f\u670d\uff0c\u5e94\u5728\u5f53\u5929\u5c3d\u5feb\u8865\u670d\u3002\u5728\u7b2c\u4e8c\u5929\u91cd\u65b0\u6062\u590d\u672c\u54c1\u7684\u5e38\u89c4\u65e5\u5242\u91cf\u670d\u836f\u8ba1\u5212\u3002\u82e5\u5728\u670d\u836f\u540e\u53d1\u751f\u5455\u5410\u8bf7\u52ff\u8865\u670d\u989d\u5916\u5242\u91cf\uff0c\u4f46\u53ef\u6309\u8ba1\u5212\u7ee7\u7eed\u670d\u7528\u4e0b\u4e2a\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u51fa\u73b0\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u6839\u636e\u60a3\u8005\u7684\u8010\u53d7\u6027\uff0c\u4ee5\u6bcf\u6b21\u51cf\u91cf<span>100mg<\/span>\u7684\u65b9\u5f0f\u9010\u6b65\u964d\u4f4e\u672c\u54c1\u7684\u5242\u91cf\uff1a\uff08<span>1<\/span>\uff09\u9996\u6b21\u51cf\u91cf\u81f3<span>300mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u3002\uff08<span>2<\/span>\uff09\u7b2c\u4e8c\u6b21\u51cf\u91cf\u81f3<span>200mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u3002\uff08<span>3<\/span>\uff09\u7b2c\u4e09\u6b21\u51cf\u91cf\u81f3<span>100mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u3002\u5982\u679c\u60a3\u8005\u4e0d\u8010\u53d7<span>100mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u7684\u7ed9\u836f\u5242\u91cf\uff0c\u5e94\u8be5\u6c38\u4e45\u505c\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u53d1\u751f\u7387\u2265<span>25%<\/span>\uff09\u4e3a\u4fbf\u79d8\u3001\u9ad8\u8840\u538b\u3001\u75b2\u4e4f\u3001\u9aa8\u9abc\u808c\u8089\u75bc\u75db\u548c\u8179\u6cfb\u3002\u6700\u5e38\u89c1\u7684<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u7ed3\u679c\u5f02\u5e38\uff08\u53d1\u751f\u7387\u2265<span>2%<\/span>\uff09\u4e3a\u6dcb\u5df4\u7ec6\u80de\u964d\u4f4e\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u964d\u4f4e\u3001\u8840\u7ea2\u86cb\u767d\u964d\u4f4e\u3001\u78f7\u9178\u76d0\u964d\u4f4e\u3001\u9499\u964d\u4f4e\uff08\u6821\u6b63\uff09\u3001\u8840\u94a0\u964d\u4f4e\u3001<span>AST<\/span>\u5347\u9ad8\u3001<span>ALT<\/span>\u5347\u9ad8\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u548c\u78b1\u6027\u78f7\u9178\u9176\u5347\u9ad8\u3002\u5e94\u7279\u522b\u6ce8\u610f\u975e\u611f\u67d3\u6027\u80ba\u708e<span>\/<\/span>\u95f4\u8d28\u6027\u80ba\u708e\u53d1\u751f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u4e0e\u5f3a\u6548\u7684<span>P-<\/span>\u7cd6\u86cb\u767d\u548c<span>CYP3A<\/span>\u5171\u540c\u6291\u5236\u5242\u53ca<span>CYP3A<\/span>\u6291\u5236\u5242\u6216\u8bf1\u5bfc\u5242\uff08\u5982\u4f0f\u7acb\u5eb7\u5511\u3001\u82ef\u59a5\u82f1\u3001\u5361\u9a6c\u897f\u5e73\u3001\u5229\u798f\u5e73\u7b49\uff09\u8054\u5408\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u516b\u3001\u8d5b\u6c83\u66ff\u5c3c<span> Savolitinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>100mg<\/span>\u3001<span>200mg <\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d5b\u6c83\u66ff\u5c3c\u7528\u4e8e\u542b\u94c2\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u8010\u53d7\u6807\u51c6\u542b\u94c2\u5316\u7597\u7684\u3001\u5177\u6709\u95f4\u8d28<span>&#8211;<\/span>\u4e0a\u76ae\u8f6c\u5316\u56e0\u5b50\uff08<span>MET<\/span>\uff09\u5916\u663e\u5b50<span>14<\/span>\u8df3\u8dc3\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u6210\u4eba\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u6709\u7ecf\u5145\u5206\u9a8c\u8bc1\u7684\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230<span>MET<\/span>\u5916\u663e\u5b50<span>14<\/span>\u8df3\u8dc3\u7a81\u53d8\u3002\u5bf9\u4e8e\u80ba\u8089\u7624\u6837\u764c\uff0c\u66f4\u5e94\u6ce8\u610f\u68c0\u6d4b<span>MET<\/span>\u5916\u663e\u5b50<span>14<\/span>\u8df3\u8dc3\u7a81\u53d8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u4f53\u91cd\u2265<span>50kg<\/span>\u7684\u60a3\u8005\uff0c\u5efa\u8bae\u8d5b\u6c83\u66ff\u5c3c\u8d77\u59cb\u5242\u91cf\u4e3a<span>600mg<\/span>\uff0c\u5bf9\u4e8e\u4f53\u91cd\uff1c<span>50kg<\/span>\u7684\u60a3\u8005\uff0c\u5efa\u8bae\u8d77\u59cb\u5242\u91cf\u4e3a<span>400mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u53e3\u670d\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u60a3\u8005\u4e2a\u4f53\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u8c03\u6574\u7528\u836f\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<table class=\"MsoNormalTable\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"100%\" style=\"width:100.0%;border-collapse:collapse;border:none;\">\n<tbody>\n<tr>\n<td width=\"100%\" colspan=\"3\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"center\" style=\"margin-left:0cm;text-align:center;\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8868<span>3<\/span>&emsp;\u8d5b\u6c83\u66ff\u5c3c\u5242\u91cf\u8c03\u6574\u5efa\u8bae<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"36%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u6c34\u5e73<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"63%\" colspan=\"2\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d5b\u6c83\u66ff\u5c3c\u6bcf\u5929\u53e3\u670d\u5242\u91cf<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"36%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d77\u59cb\u5242\u91cf<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"31%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">600mg<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6bcf\u5929\u4e00\u6b21<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08\u4f53\u91cd<span>\u226550kg<\/span>\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"31%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">400mg<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6bcf\u5929\u4e00\u6b21<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08\u4f53\u91cd\uff1c<span>50kg<\/span>\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"36%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u6c34\u5e73<span>-1<\/span>\uff08\u7b2c\u4e00\u6b21\u51cf\u91cf\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"31%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">400mg<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6bcf\u5929\u4e00\u6b21<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"31%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">300mg<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6bcf\u5929\u4e00\u6b21<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"36%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u6c34\u5e73<span>-2<\/span>\uff08\u7b2c\u4e8c\u6b21\u51cf\u91cf\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"31%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">300mg<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6bcf\u5929\u4e00\u6b21<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"31%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">200mg<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6bcf\u5929\u4e00\u6b21<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"36%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" style=\"margin-left:0cm;\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u6c34\u5e73<span>-3<\/span>\uff08\u7b2c\u4e09\u6b21\u51cf\u91cf\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"31%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">200mg<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6bcf\u5929\u4e00\u6b21<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"31%\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">&#8211;<\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u9700\u6ce8\u610f\u809d\u6bd2\u6027\u3001\u53d1\u70ed\u3001\u6c34\u80bf\u4ee5\u53ca\u8d85\u654f\u53cd\u5e94\u7684\u53d1\u751f\u3002\u53d1\u751f\u7387\u2265<span>10%<\/span>\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a\u6076\u5fc3\u3001\u6c34\u80bf\u3001\u75b2\u4e4f<span>\/<\/span>\u4e4f\u529b\u3001\u5455\u5410\u3001\u98df\u6b32\u51cf\u9000\u3001\u4f4e\u767d\u86cb\u767d\u8840\u75c7\u3001\u8d2b\u8840\u3001\u53d1\u70ed\u3001\u8179\u6cfb\uff0c\u4ee5\u53ca<span>AST<\/span>\u5347\u9ad8\u548c<span>ALT<\/span>\u5347\u9ad8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u907f\u514d\u548c<span>CYP3A4<\/span>\u7684\u5f3a\u8bf1\u5bfc\u5242\uff08\u5982\u82ef\u59a5\u82f1\u3001\u5229\u798f\u5e73\u548c\u5361\u9a6c\u897f\u5e73\uff09\u540c\u65f6\u4f7f\u7528\uff0c\u5e94\u8c28\u614e\u6216\u5c3d\u53ef\u80fd\u907f\u514d\u4e0e<span>CYP3A4<\/span>\u4e2d\u5ea6\u8bf1\u5bfc\u5242\uff08\u5982\u6ce2\u751f\u5766\u3001\u4f9d\u6cd5\u97e6\u4ed1\u3001\u4f9d\u66f2\u97e6\u6797\u548c\u83ab\u8fbe\u975e\u5c3c\uff09\u5408\u7528\u3002\u5bf9\u4e8e\u8d2f\u53f6\u8fde\u7fd8\uff08<span>St.John&#8217;s Wort<\/span>\uff09\u53ca\u5176\u63d0\u53d6\u7269\u5e94\u5728\u672c\u54c1\u670d\u7528\u524d<span>3<\/span>\u5468\u7981\u670d\u3002\u5e94\u614e\u7528\u4e8c\u7532\u53cc\u80cd\uff0c\u5e76\u76d1\u6d4b\u7531\u4e8e\u4e8c\u7532\u53cc\u80cd\u66b4\u9732\u91cf\u589e\u52a0\u53ef\u80fd\u5e26\u6765\u7684\u98ce\u9669\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e5d\u3001\u7eb3\u6b66\u5229\u5c24\u5355\u6297<span> Nivolumab<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:26.6pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a\u6ce8\u5c04\u6db2\uff1a<span>40mg<\/span>\uff08<span>4ml<\/span>\uff09<span>\/<\/span>\u74f6\u3001<span>100mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5355\u836f\u9002\u7528\u4e8e\u6cbb\u7597<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c<span>ALK<\/span>\u9634\u6027\u3001\u65e2\u5f80\u63a5\u53d7\u8fc7\u542b\u94c2\u65b9\u6848\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u6210\u4eba\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\u7528\u4e8e\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u3001\u521d\u6cbb\u7684\u975e\u4e0a\u76ae\u6837\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u6210\u4eba\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u6210\u4eba\u60a3\u8005\uff0c\u65e2\u5f80\u63a5\u53d7\u8fc7\u542b\u94c2\u65b9\u6848\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u60a3\u8005\u5fc5\u987b\u4e3a<span>EGFR<\/span>\u9634\u6027\u548c<span>ALK<\/span>\u9634\u6027\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53ea\u8981\u89c2\u5bdf\u5230\u4e34\u5e8a\u83b7\u76ca\uff0c\u5e94\u7ee7\u7eed\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\uff0c\u76f4\u81f3\u60a3\u8005\u4e0d\u80fd\u8010\u53d7\uff0c\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\uff08\u4f8b\u5982\u6700\u521d\u51e0\u4e2a\u6708\u5185\u80bf\u7624\u6682\u65f6\u589e\u5927\u6216\u51fa\u73b0\u65b0\u7684\u5c0f\u75c5\u7076\uff0c\u968f\u540e\u80bf\u7624\u7f29\u5c0f\uff09\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u5728\u4e2d\u56fd\u57fa\u4e8e<span>CheckMate 078<\/span>\u7814\u7a76\uff0c\u5355\u836f\u4f7f\u7528\u83b7\u6279\u7684\u5242\u91cf\u662f<span>3mg\/kg<\/span>\u6216<span>240mg<\/span>\u56fa\u5b9a\u5242\u91cf\uff0c\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff0c<span>30<\/span>\u5206\u949f\u8f93\u6ce8\u3002\u5728\u6b27\u7f8e\uff0c\u57fa\u4e8e<span>PPK<\/span>\u7814\u7a76\uff0c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u5df2\u7ecf\u83b7\u6279\u56fa\u5b9a\u5242\u91cf\uff0c<span>480mg<\/span>\u3001\u6bcf<span>4<\/span>\u5468\u4e00\u6b21\u6216\u8005<span>240mg<\/span>\u3001\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff0c<span>30<\/span>\u5206\u949f\u8f93\u6ce8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u53ef\u91c7\u7528<span>10mg\/ml <\/span>\u6eb6\u6db2\u76f4\u63a5\u8f93\u6ce8\uff0c\u6216\u8005\u91c7\u7528\u6ce8\u5c04\u7528\u6c2f\u5316\u94a0\u6eb6\u6db2\uff08<span>9mg\/ml<\/span>\uff0c<span>0.9%<\/span>\uff09\u6216\u6ce8\u5c04\u7528\u8461\u8404\u7cd6\u6eb6\u6db2\uff08<span>50mg\/ml<\/span>\uff0c<span>5%<\/span>\uff09\u7a00\u91ca\uff0c\u6d53\u5ea6\u53ef\u4f4e\u81f3<span>1mg\/ml<\/span>\u3002\u603b\u8f93\u6ce8\u91cf\u4e00\u5b9a\u4e0d\u80fd\u8d85\u8fc7<span>160ml<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0e\u4f0a\u5339\u6728\u5355\u6297\u8054\u5408\u6cbb\u7597\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u63a8\u8350\u5242\u91cf\u4e3a<span>360mg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c\u6216<span>3mg\/kg<\/span>\uff0c\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff0c\u9759\u8109\u8f93\u6ce8<span>30<\/span>\u5206\u949f\uff0c\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297<span>1mg\/kg<\/span>\uff0c\u6bcf<span>6<\/span>\u5468\u4e00\u6b21\uff0c\u9759\u8109\u8f93\u6ce8<span>30<\/span>\u5206\u949f\u3002\u5bf9\u4e8e\u6ca1\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u60a3\u8005\uff0c\u6cbb\u7597\u6301\u7eed\u6700\u957f\u81f3<span>24<\/span>\u4e2a\u6708\u3002\u4e0e\u4f0a\u5339\u6728\u5355\u6297\u8054\u7528\u65f6\uff0c\u5e94\u5148\u8f93\u6ce8\u672c\u54c1\uff0c\u4e4b\u540e\u540c\u4e00\u5929\u8f93\u6ce8\u4f0a\u5339\u6728\u5355\u6297\u3002\u6bcf\u6b21\u8f93\u6ce8\u9700\u4f7f\u7528\u5355\u72ec\u7684\u8f93\u6db2\u888b\u548c\u8fc7\u6ee4\u5668\uff0c\u8f93\u6ce8\u7ed3\u675f\u65f6\u51b2\u6d17\u8f93\u6db2\u7ba1\uff0c\u8bf7\u52ff\u901a\u8fc7\u540c\u4e00\u6839\u8f93\u6db2\u7ba1\u540c\u65f6\u7ed9\u4e88\u5176\u4ed6\u836f\u7269\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;color:red;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u6682\u505c\u7ed9\u836f\u6216\u505c\u836f\u3002\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53d1\u751f<span>4<\/span>\u7ea7\u6216\u590d\u53d1\u6027<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u867d\u7136\u8fdb\u884c\u6cbb\u7597\u8c03\u6574\u4f46\u4ecd\u6301\u7eed\u5b58\u5728<span>2<\/span>\u7ea7\u6216<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u6c38\u4e45\u6027\u505c\u7528\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8001\u5e74\u60a3\u8005\uff08\u2265<span>65<\/span>\u5c81\uff09\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u6570\u636e\u6709\u9650\u3002\u8f7b\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u6ca1\u6709\u5bf9\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u8fdb\u884c\u672c\u54c1\u7684\u76f8\u5173\u7814\u7a76\uff0c\u91cd\u5ea6\uff08\u603b\u80c6\u7ea2\u7d20\u3001<span>ALT<\/span>\u6216<span>AST<\/span>\uff1e<span>3<\/span>\u500d\u6b63\u5e38\u503c\u4e0a\u9650\uff09\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5fc5\u987b\u614e\u7528\u672c\u54c1\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u53ef\u5f15\u8d77\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u3002\u56e0\u4e3a\u4e0d\u826f\u53cd\u5e94\u53ef\u80fd\u5728\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u671f\u95f4\u6216\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u505c\u6b62\u540e\u7684\u4efb\u4f55\u65f6\u95f4\u53d1\u751f\uff0c\u5e94\u6301\u7eed\u8fdb\u884c\u60a3\u8005\u76d1\u6d4b\uff08\u81f3\u5c11\u81f3\u672b\u6b21\u7ed9\u836f\u540e<span>5<\/span>\u4e2a\u6708\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">12.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u5e94\u6682\u505c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u5e76\u7ed9\u4e88\u7cd6\u76ae\u8d28\u6fc0\u7d20\u3002\u82e5\u4f7f\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u514d\u75ab\u6291\u5236\u7597\u6cd5\u6cbb\u7597\u4e0d\u826f\u53cd\u5e94\uff0c\u75c7\u72b6\u6539\u5584\u540e\uff0c\u9700\u81f3\u5c11<span>1<\/span>\u4e2a\u6708\u7684\u65f6\u95f4\u9010\u6e10\u51cf\u91cf\u81f3\u505c\u836f\u3002\u5feb\u901f\u51cf\u91cf\u53ef\u80fd\u5f15\u8d77\u4e0d\u826f\u53cd\u5e94\u6076\u5316\u6216\u590d\u53d1\u3002\u5982\u679c\u4f7f\u7528\u4e86\u7cd6\u76ae\u8d28\u6fc0\u7d20\u4f46\u4ecd\u6076\u5316\u6216\u65e0\u6539\u5584\uff0c\u5219\u5e94\u589e\u52a0\u975e\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6027\u514d\u75ab\u6291\u5236\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">13.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u60a3\u8005\u63a5\u53d7\u514d\u75ab\u6291\u5236\u5242\u91cf\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u6cbb\u7597\u671f\u95f4\uff0c\u4e0d\u53ef\u91cd\u65b0\u4f7f\u7528\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">14.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u51fa\u73b0\u4efb\u4f55\u91cd\u5ea6\u3001\u590d\u53d1\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u4ee5\u53ca\u4efb\u4f55\u5371\u53ca\u751f\u547d\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5fc5\u987b\u6c38\u4e45\u505c\u6b62\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">15.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6ce8\u5c04\u6db2\u6bcf\u6beb\u5347\u542b<span>0.1mmol<\/span>\uff08\u6216<span>2.5mg<\/span>\uff09\u94a0\uff0c\u5728\u5bf9\u63a7\u5236\u94a0\u6444\u5165\u7684\u60a3\u8005\u8fdb\u884c\u6cbb\u7597\u65f6\u5e94\u8003\u8651\u8fd9\u4e00\u56e0\u7d20\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">16.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u662f\u4e00\u79cd\u4eba\u5355\u514b\u9686\u6297\u4f53\uff0c\u56e0\u5355\u514b\u9686\u6297\u4f53\u4e0d\u7ecf<span>CYP450<\/span>\u6216\u5176\u4ed6\u836f\u7269\u4ee3\u8c22\u9176\u4ee3\u8c22\uff0c\u56e0\u6b64\uff0c\u5408\u5e76\u4f7f\u7528\u7684\u836f\u7269\u5bf9\u8fd9\u4e9b\u9176\u7684\u6291\u5236\u6216\u8bf1\u5bfc\u4f5c\u7528\u9884\u671f\u4e0d\u4f1a\u5f71\u54cd\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u6027\u8d28\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">17.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5f53\u672c\u54c1\u4e0e\u4f0a\u5339\u6728\u5355\u6297\u8054\u5408\u6cbb\u7597\u65f6\uff0c\u82e5\u6682\u505c\u4efb\u4e00\u836f\u7269\uff0c\u5219\u5e94\u540c\u65f6\u6682\u505c\u53e6\u4e00\u836f\u7269\u3002\u82e5\u5728\u6682\u505c\u540e\u91cd\u65b0\u5f00\u59cb\u7ed9\u836f\uff0c\u5219\u5e94\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u8bc4\u4f30\u60c5\u51b5\u91cd\u65b0\u5f00\u59cb\u8054\u5408\u6cbb\u7597\u6216\u672c\u54c1\u5355\u836f\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">18.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7f8e\u56fd<span>FDA<\/span>\u6279\u51c6\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u80bf\u7624<span>PD-L1<\/span>\u8868\u8fbe\u9633\u6027\uff08\u5b9a\u4e49\u4e3a\u8868\u8fbe<span>PD-L1<\/span>\u7684\u80bf\u7624\u7ec6\u80de\u2265<span>1%<\/span>\uff09\u3001<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c<span>ALK<\/span>\u9634\u6027\u3001\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\uff0c\u76ee\u524d\u56fd\u5185\u5c1a\u672a\u83b7\u6279\u6b64\u9002\u5e94\u8bc1\uff0c\u53ef\u5728\u4e0e\u60a3\u8005\u5145\u5206\u6c9f\u901a\u7684\u60c5\u51b5\u4e0b\u4f7f\u7528\u3002\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u7528\u6cd5\u4e3a<span>3mg\/kg<\/span>\uff0c\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff1b\u4f0a\u5339\u6728\u5355\u6297\u7528\u6cd5\u4e3a<span>1mg\/kg<\/span>\uff0c\u6bcf<span>6<\/span>\u5468\u4e00\u6b21\u3002\u6b64\u5916\uff0c\u7f8e\u56fd<span>FDA<\/span>\u548c\u6b27\u76df<span>EMA<\/span>\u8fd8\u6279\u51c6\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\u548c\u4e24\u5468\u671f\u542b\u94c2\u53cc\u836f\u5316\u7597\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c<span>ALK<\/span>\u9634\u6027\u3001\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\uff0c\u76ee\u524d\u56fd\u5185\u5c1a\u672a\u83b7\u6279\u6b64\u9002\u5e94\u8bc1\uff0c\u53ef\u5728\u4e0e\u60a3\u8005\u5145\u5206\u6c9f\u901a\u7684\u60c5\u51b5\u4e0b\u4f7f\u7528\u3002\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u7528\u6cd5\u4e3a<span>360mg<\/span>\u56fa\u5b9a\u5242\u91cf\uff0c\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff1b\u4f0a\u5339\u6728\u5355\u6297\u7528\u6cd5\u4e3a<span>1mg\/kg<\/span>\uff0c\u6bcf<span>6<\/span>\u5468\u4e00\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u3001\u5e15\u535a\u5229\u73e0\u5355\u6297<span> Pembrolizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>4ml<\/span>\uff09<span>\/<\/span>\u74f6 <span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u94c2\u7c7b\u5316\u7597\u836f\u9002\u7528\u4e8e<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c<span>ALK<\/span>\u9634\u6027\u7684\u8f6c\u79fb\u6027\u975e\u9cde\u72b6<span>NSCLC<\/span>\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u9002\u7528\u4e8e\u7531\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u8bc4\u4f30\u4e3a<span>PD-L1<\/span>\u80bf\u7624\u6bd4\u4f8b\u5206\u6570\uff08<span>TPS<\/span>\uff09\u2265<span>1%<\/span>\u7684<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c<span>ALK<\/span>\u9634\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u4e00\u7ebf\u5355\u836f\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u5361\u94c2\u548c\u7d2b\u6749\u9187\u9002\u7528\u4e8e\u8f6c\u79fb\u6027\u9cde\u72b6<span>NSCLC<\/span>\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53ea\u8981\u89c2\u5bdf\u5230\u4e34\u5e8a\u83b7\u76ca\uff0c\u5e94\u7ee7\u7eed\u4f7f\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u53d1\u751f\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\uff0c\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u4f46\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u9996\u4e2a\u4e00\u7ebf\u80ba\u764c\u9002\u5e94\u8bc1\u662f\u57fa\u4e8e\u5168\u7403\u2162\u671f\u4e34\u5e8a\u7814\u7a76<span>KEYNOTE-189<\/span>\u7814\u7a76\u7ed3\u679c\uff0c\u5728\u4e2d\u56fd\u83b7\u6279\u7684\u80ba\u764c\u9002\u5e94\u8bc1\u5242\u91cf\u662f<span>200mg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c\u6216<span>400mg<\/span>\uff0c\u6bcf<span>6<\/span>\u5468\u4e00\u6b21\uff0c\u901a\u8fc7\u9759\u8109\u8f93\u6ce8\u7ed9\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u4f7f\u7528\u672c\u54c1\u4e4b\u524d\u5e94\u907f\u514d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u836f\u7269\u53ef\u80fd\u4f1a\u5f71\u54cd\u672c\u54c1\u7684\u836f\u6548\u5b66\u6d3b\u6027\u53ca\u7597\u6548\u3002\u4f46\u5728\u672c\u54c1\u5f00\u59cb\u7ed9\u836f\u540e\uff0c\u53ef\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u514d\u75ab\u4ecb\u5bfc\u6027\u4e0d\u826f\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u505c\u836f\uff0c\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53d1\u751f<span>4<\/span>\u7ea7\u6216\u590d\u53d1\u6027<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u867d\u7136\u8fdb\u884c\u6cbb\u7597\u8c03\u6574\u4f46\u4ecd\u6301\u7eed\u5b58\u5728<span>2<\/span>\u7ea7\u6216<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u6c38\u4e45\u6027\u505c\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8001\u5e74\u60a3\u8005\uff08\u2265<span>65<\/span>\u5c81\uff09\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u6570\u636e\u6709\u9650\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u5c1a\u672a\u5728\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u8fdb\u884c\u672c\u54c1\u7684\u76f8\u5173\u7814\u7a76\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u53ef\u5f15\u8d77\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u3002\u56e0\u4e3a\u4e0d\u826f\u53cd\u5e94\u53ef\u80fd\u5728\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u671f\u95f4\u6216\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u505c\u6b62\u540e\u7684\u4efb\u4f55\u65f6\u95f4\u53d1\u751f\uff0c\u5e94\u6301\u7eed\u8fdb\u884c\u60a3\u8005\u76d1\u6d4b\uff08\u81f3\u5c11\u81f3\u672b\u6b21\u7ed9\u836f\u540e<span>5<\/span>\u4e2a\u6708\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u5e94\u6682\u65f6\u505c\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\uff0c\u5e76\u5e94\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u3002\u5f53\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u6539\u5584\u81f3\u2264<span>1<\/span>\u7ea7\u65f6\uff0c\u9700\u81f3\u5c11\u4e00\u4e2a\u6708\u7684\u65f6\u95f4\u9010\u6b65\u51cf\u5c11\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7684\u7528\u91cf\u76f4\u81f3\u505c\u836f\u3002\u57fa\u4e8e\u6709\u9650\u7684\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff0c\u53d1\u751f\u7cd6\u76ae\u8d28\u6fc0\u7d20\u65e0\u6cd5\u63a7\u5236\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u65f6\u53ef\u4ee5\u8003\u8651\u4f7f\u7528\u5176\u4ed6\u5168\u8eab\u6027\u514d\u75ab\u6291\u5236\u5242\u3002\u5982\u679c\u4e0d\u826f\u53cd\u5e94\u4fdd\u6301\u5728\u2264<span>1<\/span>\u7ea7\uff0c\u4e14\u7cd6\u76ae\u8d28\u6fc0\u7d20\u5242\u91cf\u5df2\u964d\u81f3\u6bcf\u5929\u2264<span>10mg<\/span>\u6cfc\u5c3c\u677e\u6216\u7b49\u6548\u5242\u91cf\uff0c\u5219\u53ef\u5728\u6700\u540e\u4e00\u6b21\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ed9\u836f\u540e<span>12<\/span>\u5468\u5185\u91cd\u65b0\u5f00\u59cb\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u60a3\u8005\u63a5\u53d7\u514d\u75ab\u6291\u5236\u5242\u91cf\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u671f\u95f4\uff0c\u4e0d\u53ef\u91cd\u65b0\u4f7f\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">12.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u51fa\u73b0\u4efb\u4f55\u91cd\u5ea6\u3001\u590d\u53d1\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u4ee5\u53ca\u4efb\u4f55\u5371\u53ca\u751f\u547d\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5fc5\u987b\u6c38\u4e45\u505c\u6b62\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">13.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u662f\u4e00\u79cd\u4eba\u5355\u514b\u9686\u6297\u4f53\uff0c\u56e0\u5355\u514b\u9686\u6297\u4f53\u4e0d\u7ecf<span>CYP450<\/span>\u6216\u5176\u4ed6\u836f\u7269\u4ee3\u8c22\u9176\u4ee3\u8c22\uff0c\u56e0\u6b64\uff0c\u5408\u5e76\u4f7f\u7528\u7684\u836f\u7269\u5bf9\u8fd9\u4e9b\u9176\u7684\u6291\u5236\u6216\u8bf1\u5bfc\u4f5c\u7528\u9884\u671f\u4e0d\u4f1a\u5f71\u54cd\u5e15\u535a\u5229\u73e0\u5355\u6297\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u6027\u8d28\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">14.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7f8e\u56fd<span>FDA<\/span>\u3001\u6b27\u76df<span>EMA<\/span>\u548c\u65e5\u672c<span>PMDA<\/span>\u6279\u51c6\u5e15\u535a\u5229\u73e0\u5355\u6297\u7684\u9002\u5e94\u8bc1\u8fd8\u5305\u62ec\uff1a\u5728\u6392\u9664<span>EGFR<\/span>\u6216<span>ALK<\/span>\u9633\u6027\u57fa\u7840\u4e0a\uff0c\u7528\u4e8e<span>PD-L1<\/span>\u8868\u8fbe\u2265<span>1%<\/span>\u7684\u665a\u671f<span>NSCLC<\/span>\u4e8c\u7ebf\u5355\u836f\u6cbb\u7597\u3002\u7f8e\u56fd<span>FDA<\/span>\u8fd8\u6279\u51c6\u5e15\u535a\u5229\u73e0\u5355\u6297\u5355\u836f\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u548c\u513f\u7ae5\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027<span>MSI-H<\/span>\u6216\u9519\u914d\u4fee\u590d\u7f3a\u9677\u7684\u5b9e\u4f53\u7624\u4ee5\u53ca\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\u9ad8\uff08<span>TMB-H<\/span>\uff09\u7684\u65e0\u6cd5\u5207\u9664\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\uff08\u5305\u62ec\u5c0f\u7ec6\u80de\u80ba\u764c\uff09\u3002\u76ee\u524d\u56fd\u5185\u5c1a\u672a\u83b7\u6279\u8fd9\u4e9b\u9002\u5e94\u8bc1\uff0c\u53ef\u5728\u4e0e\u60a3\u8005\u5145\u5206\u6c9f\u901a\u7684\u60c5\u51b5\u4e0b\u3001\u6309\u7167<span>FDA<\/span>\u6279\u51c6\u7684\u7528\u6cd5\u6b63\u786e\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e00\u3001\u5ea6\u4f10\u5229\u5c24\u5355\u6297<span> Durvalumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>120mg<\/span>\uff08<span>2.4ml<\/span>\uff09<span>\/<\/span>\u74f6\u3001<span>500mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1<b>.<\/b><\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u9002\u7528\u4e8e\u5728\u63a5\u53d7\u94c2\u7c7b\u836f\u7269\u4e3a\u57fa\u7840\u7684\u5316\u7597\u540c\u6b65\u653e\u7597\u540e\u672a\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u4e0d\u53ef\u5207\u9664\u3001\u2162\u671f<span>NSCLC<\/span>\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u8054\u5408\u4f9d\u6258\u6cca\u82f7\u548c\u5361\u94c2\u6216\u987a\u94c2\uff0c\u4e00\u7ebf\u6cbb\u7597\u5e7f\u6cdb\u671f\u5c0f\u7ec6\u80de\u80ba\u764c\uff08<span>ES-SCLC<\/span>\uff09\u6210\u4eba\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u53ef\u5207\u9664\u7684\u2162\u671f<span>NSCLC<\/span>\uff1a\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u7684\u4f7f\u7528\u65b9\u6cd5\u662f<span>10mg\/kg<\/span>\uff0c\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\uff0c\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff0c\u6bcf\u6b21\u8f93\u6ce8\u9700\u8d85\u8fc7<span>60<\/span>\u5206\u949f\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u80fd\u8010\u53d7\u7684\u6bd2\u6027\u3002\u6700\u957f\u4f7f\u7528\u4e0d\u8d85\u8fc7<span>12<\/span>\u4e2a\u6708\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.ES-SCLC<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a<span>1500mg<\/span>\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u8054\u5408\u4f9d\u6258\u6cca\u82f7\u548c\u5361\u94c2\u6216\u987a\u94c2\uff0c\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c\u6301\u7eed<span>4<\/span>\u4e2a\u5468\u671f\uff0c\u7ee7\u4e4b\u4ee5<span>1500mg<\/span>\u6bcf<span>4<\/span>\u5468\u4e00\u6b21\u4f5c\u4e3a\u5355\u836f\u6cbb\u7597\uff0c\u76f4\u81f3\u53d1\u751f\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u80fd\u8010\u53d7\u7684\u6bd2\u6027\u3002\u4f53\u91cd\u5728<span>30kg<\/span>\u6216\u4ee5\u4e0b\u7684\u60a3\u8005\u5fc5\u987b\u63a5\u53d7\u57fa\u4e8e\u4f53\u91cd\u7684\u7ed9\u836f\uff0c\u5373\u5ea6\u4f10\u5229\u5c24\u5355\u6297<span>20mg\/kg<\/span>\u8054\u5408\u5316\u7597\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c\u6301\u7eed<span>4<\/span>\u4e2a\u5468\u671f\uff0c\u7ee7\u4e4b\u4ee5<span>20mg\/kg<\/span>\u6bcf<span>4<\/span>\u5468\u4e00\u6b21\u5355\u836f\u6cbb\u7597\uff0c\u76f4\u81f3\u4f53\u91cd\u589e\u52a0\u81f3\u5927\u4e8e<span>30kg<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><a name=\"_Hlk59364010\"><\/a><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u7684\u7c7b\u578b\u548c\u4e25\u91cd\u7a0b\u5ea6\uff0c\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\uff0c\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c1a\u672a\u786e\u7acb\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u5728<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u53ca\u9752\u5c11\u5e74\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u8001\u5e74\u60a3\u8005\uff08\u2265<span>65<\/span>\u5c81\uff09\u3001\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u3001\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u5747\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002\u5728\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u3001\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u4f7f\u7528\u7684\u5b89\u5168\u6027\u53ca\u6709\u6548\u6027\u5c1a\u672a\u5efa\u7acb\uff0c\u5982\u7ecf\u533b\u5e08\u8bc4\u4f30\u4f7f\u7528\u672c\u54c1\u9884\u671f\u83b7\u76ca\u5927\u4e8e\u98ce\u9669\uff0c\u9700\u5728\u533b\u5e08\u6307\u5bfc\u4e0b\u8c28\u614e\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e8c\u3001\u963f\u66ff\u5229\u73e0\u5355\u6297<span> Atezolizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>1200mg<\/span>\uff08<span>20ml<\/span>\uff09<span>\/<\/span>\u74f6 <span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u66ff\u5229\u73e0\u5355\u6297\u4e0e\u5361\u94c2\u548c\u4f9d\u6258\u6cca\u82f7\u8054\u5408\u7528\u4e8e<span>ES-SCLC<\/span>\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u66ff\u5229\u73e0\u5355\u6297\u7528\u4e8e\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u8bc4\u4f30\u4e3a\u2265<span>50%<\/span>\u80bf\u7624\u7ec6\u80de<span>PD-L1<\/span>\u67d3\u8272\u9633\u6027\uff08<span>TC<\/span>\u2265<span>50%<\/span>\uff09\u6216\u80bf\u7624\u6d78\u6da6<span>PD-L1<\/span>\u9633\u6027\u514d\u75ab\u7ec6\u80de\uff08<span>IC<\/span>\uff09\u8986\u76d6\u2265<span>10%<\/span>\u7684\u80bf\u7624\u9762\u79ef\uff08<span>IC<\/span>\u2265<span>10%<\/span>\uff09\u7684<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c<span>ALK<\/span>\u9634\u6027\u7684\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u4e00\u7ebf\u5355\u836f\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u66ff\u5229\u73e0\u5355\u6297\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u94c2\u7c7b\u5316\u7597\u7528\u4e8e<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c<span>ALK<\/span>\u9634\u6027\u7684\u8f6c\u79fb\u6027\u975e\u9cde\u72b6<span>NSCLC<\/span>\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u66ff\u5229\u73e0\u5355\u6297\u7684\u7528\u6cd5\u662f\u56fa\u5b9a\u5242\u91cf<span>1200mg<\/span>\uff0c\u901a\u8fc7\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\uff0c\u9996\u6b21\u7ed9\u836f\u81f3\u5c11\u6301\u7eed<span>60<\/span>\u5206\u949f\uff0c\u82e5\u9996\u6b21\u8f93\u6ce8\u60a3\u8005\u8010\u53d7\u6027\u826f\u597d\uff0c\u540e\u7eed\u53ef\u81f3\u5c11<span>30<\/span>\u5206\u949f\u3002\u7528\u4e8e<span>ES-SCLC<\/span>\u65f6\uff0c\u8bf1\u5bfc\u671f\u8054\u5408\u5361\u94c2\u548c\u4f9d\u6258\u6cca\u82f7\u65b9\u6848\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c\u6cbb\u7597<span>4<\/span>\u4e2a\u5468\u671f\u540e\u8fdb\u5165\u65e0\u5316\u7597\u7684\u7ef4\u6301\u671f\u3002\u7528\u4e8e<span>NSCLC<\/span>\u4e00\u7ebf\u5355\u836f\u6cbb\u7597\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\u3002\u7528\u4e8e<span>NSCLC<\/span>\u4e00\u7ebf\u8054\u5408\u5316\u7597\u65f6\uff0c\u8bf1\u5bfc\u671f\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u94c2\u7c7b\u65b9\u6848\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c\u6cbb\u7597<span>4<\/span>\u4e2a\u6216<span>6<\/span>\u4e2a\u6cbb\u7597\u5468\u671f\u540e\u8fdb\u5165\u963f\u66ff\u5229\u73e0\u5355\u6297\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u7684\u7ef4\u6301\u671f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u60a3\u8005\u53ef\u63a5\u53d7\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u76f4\u81f3\u65e0\u4e34\u5e8a\u83b7\u76ca\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u4f46\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\u3002\u5e94\u5bf9\u75be\u75c5\u8fdb\u5c55\u540e\u7ee7\u7eed\u4f7f\u7528\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u5f00\u5c55\u5bc6\u5207\u76d1\u6d4b\uff0c<span>4<\/span>\uff5e<span>8<\/span>\u5468\u5185\u91cd\u590d\u80bf\u7624\u7597\u6548\u8bc4\u4f30\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u6839\u636e\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u7684\u7c7b\u578b\u548c\u4e25\u91cd\u7a0b\u5ea6\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\uff0c\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u4f7f\u7528\u672c\u54c1\u4e4b\u524d\u5e94\u5c3d\u91cf\u907f\u514d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u836f\u7269\u53ef\u80fd\u4f1a\u5f71\u54cd\u672c\u54c1\u7684\u836f\u6548\u5b66\u6d3b\u6027\u53ca\u7597\u6548\u3002\u4f46\u5728\u672c\u54c1\u5f00\u59cb\u7ed9\u836f\u540e\uff0c\u53ef\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u3002\u5728\u60a3\u8005\u63a5\u53d7\u8fbe\u5230\u514d\u75ab\u6291\u5236\u5242\u91cf\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u671f\u95f4\uff0c\u4e0d\u5efa\u8bae\u91cd\u65b0\u4f7f\u7528\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c1a\u672a\u786e\u7acb\u963f\u66ff\u5229\u73e0\u5355\u6297\u5728<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u548c\u9752\u5c11\u5e74\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u8001\u5e74\u60a3\u8005\uff08\u2265<span>65<\/span>\u5c81\uff09\u3001\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u3001\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u5728\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u3001\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u4f7f\u7528\u7684\u5b89\u5168\u6027\u53ca\u6709\u6548\u6027\u5c1a\u672a\u5efa\u7acb\uff0c\u5982\u7ecf\u533b\u5e08\u8bc4\u4f30\u4f7f\u7528\u672c\u54c1\u9884\u671f\u83b7\u76ca\u5927\u4e8e\u98ce\u9669\uff0c\u9700\u5728\u533b\u5e08\u6307\u5bfc\u4e0b\u8c28\u614e\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7f8e\u56fd<span>FDA<\/span>\u6279\u51c6\u963f\u66ff\u5229\u73e0\u5355\u6297\u7684\u9002\u5e94\u8bc1\u8fd8\u5305\u62ec\uff1a\u963f\u66ff\u5229\u73e0\u5355\u6297\u4f5c\u4e3a<span>PD-L1 TC<\/span>\u2265<span>1% <\/span>\u2161<span>&#8211;<\/span>\u2162<span>A<\/span>\u671f<span>NSCLC<\/span>\u60a3\u8005\u63a5\u53d7\u624b\u672f\u548c\u542b\u94c2\u5316\u7597\u540e\u7684\u8f85\u52a9\u6cbb\u7597\uff1b\u8054\u5408\u767d\u86cb\u767d\u7d2b\u6749\u9187\u548c\u5361\u94c2\u7528\u4e8e<span>EGFR\/ALK<\/span>\u9634\u6027\u7684\u665a\u671f\u975e\u9cde\u72b6\u7ec6\u80de<span>NSCLC<\/span>\u4e00\u7ebf\u6cbb\u7597\uff1b\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u548c\u7d2b\u6749\u9187\u548c\u5361\u94c2\u7528\u4e8e<span>EGFR\/ALK<\/span>\u9634\u6027\u7684\u665a\u671f\u975e\u9cde\u72b6\u7ec6\u80de<span>NSCLC<\/span>\u4e00\u7ebf\u6cbb\u7597\uff1b\u963f\u66ff\u5229\u73e0\u5355\u6297\u5355\u836f\u7528\u4e8e\u665a\u671f<span>NSCLC<\/span>\u542b\u94c2\u5316\u7597\u8fdb\u5c55\u540e\u7684\u4e8c\u7ebf\u6cbb\u7597\uff1b\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u5168\u8eab\u7cfb\u7edf\u6027\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\uff1b\u4f5c\u4e3a\u4e0d\u9002\u5408\u542b\u94c2\u5316\u7597\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b\u4e0e\u5361\u6bd4\u66ff\u5c3c\u548c\u7ef4\u83ab\u975e\u5c3c\u8054\u5408\u7528\u4e8e\u6cbb\u7597<span>BRAF V600<\/span>\u7a81\u53d8\u9633\u6027\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u3002\u9664\u809d\u7ec6\u80de\u764c\u5916\uff0c\u8fd9\u4e9b\u9002\u5e94\u8bc1\u76ee\u524d\u56fd\u5185\u5c1a\u672a\u83b7\u6279\uff0c\u53ef\u5728\u4e0e\u60a3\u8005\u5145\u5206\u6c9f\u901a\u7684\u60c5\u51b5\u4e0b\u3001\u6309\u7167<span>FDA<\/span>\u6279\u51c6\u7684\u7528\u6cd5\u6b63\u786e\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e09\u3001\u5361\u745e\u5229\u73e0\u5355\u6297<span> Camrelizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7c89\u9488\u5242\uff1a<span>200mg\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5361\u745e\u5229\u73e0\u5355\u6297\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u5361\u94c2\u9002\u7528\u4e8e<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c<span>ALK<\/span>\u9634\u6027\u7684\u3001\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u7ec6\u80de<span>NSCLC<\/span>\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u8bca\u65ad\u4e3a<span>EGFR<\/span>\u7a81\u53d8\u9634\u6027\u548c<span>ALK<\/span>\u9634\u6027\u7684\u975e\u9cde\u72b6\u7ec6\u80de<span>NSCLC<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u8be5\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\u8bc4\u4f30\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u53cd\u5e94\u53ca\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u91c7\u7528\u9759\u8109\u8f93\u6ce8\u7684\u65b9\u5f0f\u7ed9\u836f\uff0c\u9759\u8109\u8f93\u6ce8\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>200mg<\/span>\uff0c\u6bcf\u6b21\u6301\u7eed<span>30<\/span>\uff5e<span>60<\/span>\u5206\u949f\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u5f53\u5361\u745e\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u7ed9\u836f\u65f6\uff0c\u5e94\u9996\u5148\u7ed9\u4e88\u5361\u745e\u5229\u73e0\u5355\u6297\u9759\u8109\u6ef4\u6ce8\uff0c\u95f4\u9694\u81f3\u5c11<span>30<\/span>\u5206\u949f\u540e\u518d\u7ed9\u4e88\u5316\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u51fa\u73b0\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\u3002\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u672c\u54c1\u5c1a\u65e0\u9488\u5bf9\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u5e08\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u672c\u54c1\u5c1a\u65e0\u9488\u5bf9\u4e2d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u4e2d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002\u8f7b\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u5e08\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5c1a\u65e0\u5728<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u53ca\u9752\u5c11\u5e74\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5728\u2265<span>65<\/span>\u5c81\u7684\u8001\u5e74\u60a3\u8005\u4e2d\u5e94\u7528\u6570\u636e\u6709\u9650\uff0c\u5efa\u8bae\u5728\u533b\u5e08\u7684\u6307\u5bfc\u4e0b\u614e\u7528\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u5efa\u8bae\u5728\u598a\u5a20\u671f\u95f4\u4f7f\u7528\u672c\u54c1\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56e0\u53ef\u80fd\u5e72\u6270\u672c\u54c1\u836f\u6548\u5b66\u6d3b\u6027\uff0c\u5e94\u907f\u514d\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002\u4f46\u662f\u5982\u679c\u4e3a\u4e86\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u540e\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">12.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5361\u745e\u5229\u73e0\u5355\u6297\u662f\u4e00\u79cd\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\uff0c\u5c1a\u672a\u8fdb\u884c\u4e0e\u5176\u4ed6\u836f\u7269\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u76f8\u4e92\u4f5c\u7528\u7814\u7a76\u3002\u56e0\u5355\u514b\u9686\u6297\u4f53\u4e0d\u7ecf<span>CYP450<\/span>\u9176\u6216\u5176\u4ed6\u836f\u7269\u4ee3\u8c22\u9176\u4ee3\u8c22\uff0c\u56e0\u6b64\u5408\u5e76\u4f7f\u7528\u7684\u836f\u7269\u5bf9\u8fd9\u4e9b\u9176\u7684\u6291\u5236\u6216\u8bf1\u5bfc\u4f5c\u7528\u9884\u671f\u4e0d\u4f1a\u5f71\u54cd\u5361\u745e\u5229\u73e0\u5355\u6297\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u6027\u8d28\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">13.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u7684\u5904\u7406\uff1a\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u5171<span>1023<\/span>\u4f8b\uff08<span>77.4%<\/span>\uff09\u53d1\u751f\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\uff0c\u5176\u4e2d<span>1<\/span>\u7ea7\u4e3a<span>827<\/span>\u4f8b\uff08<span>62.6%<\/span>\uff09\uff0c<span>2<\/span>\u7ea7\u4e3a<span>182<\/span>\u4f8b\uff08<span>13.8%<\/span>\uff09\uff0c<span>3<\/span>\u7ea7\u4e3a<span>14<\/span>\u4f8b\uff08<span>1.1%<\/span>\uff09\u3002\u6240\u6709\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u5747\u53d1\u751f\u5728\u4f53\u8868\uff0c\u5176\u4e2d<span>3.9%<\/span>\uff08<span>52\/1321<\/span>\uff09\u4f34\u53d1\u4e8e\u53e3\u8154\u3001<span>1.1%<\/span>\uff08<span>14\/1321<\/span>\uff09\u4f34\u53d1\u4e8e\u9f3b\u8154\u9ecf\u819c\u3001<span>0.5%<\/span>\uff08<span>7\/1321<\/span>\uff09\u4f34\u53d1\u4e8e\u773c\u7751\u3001<span>0.5%<\/span>\uff08<span>6\/1321<\/span>\uff09\u4f34\u53d1\u4e8e\u773c\u90e8\uff1b<span>16.5%<\/span>\u53d1\u751f\u5408\u5e76\u51fa\u8840\uff0c<span>1.1%<\/span>\u53d1\u751f\u5408\u5e76\u611f\u67d3\u3002\u81f3\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u53d1\u751f\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a<span>0.9<\/span>\u4e2a\u6708\uff08\u8303\u56f4\uff1a<span>0.0<\/span>\uff5e<span>8.1<\/span>\u4e2a\u6708\uff09\uff0c\u6301\u7eed\u7684\u4e2d\u4f4d\u65f6\u95f4\u662f<span>6.3<\/span>\u4e2a\u6708\uff08\u8303\u56f4\uff1a<span>0.2<\/span>\uff5e<span>32.8<\/span>\u4e2a\u6708\uff09\u3002\u53d1\u751f\u4e8e\u76ae\u80a4\u7684\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\uff0c\u521d\u59cb\u591a\u8868\u73b0\u4e3a\u4f53\u8868\u9c9c\u7ea2\u8272\u70b9\u72b6\u7269\uff0c\u76f4\u5f84\u2264<span>2mm<\/span>\uff0c\u968f\u7740\u7528\u836f\u6b21\u6570\u589e\u52a0\uff0c\u75c5\u53d8\u8303\u56f4\u53ef\u9010\u6e10\u589e\u5927\uff0c\u591a\u4e3a\u7ed3\u8282\u72b6\uff0c\u4e5f\u6709\u6591\u7247\u72b6\uff0c\u989c\u8272\u9c9c\u7ea2\u6216\u6697\u7ea2\uff0c\u9700\u89c2\u5bdf\u4e34\u5e8a\u75c7\u72b6\u548c\u4f53\u5f81\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5f53\u60a3\u8005\u51fa\u73b0\u8be5\u4e0d\u826f\u53cd\u5e94\u65f6\uff0c\u5e94\u907f\u514d\u6293\u6320\u6216\u6469\u64e6\uff0c\u6613\u6469\u64e6\u90e8\u4f4d\u53ef\u7528\u7eb1\u5e03\u4fdd\u62a4\u4ee5\u907f\u514d\u51fa\u8840\uff0c\u540c\u65f6\u5e94\u8054\u7cfb\u4e3b\u7ba1\u533b\u5e08\uff0c\u83b7\u5f97\u6070\u5f53\u7684\u5904\u7406\u5efa\u8bae\u3002\u7834\u6e83\u51fa\u8840\u8005\u53ef\u91c7\u7528\u5c40\u90e8\u538b\u8feb\u6b62\u8840\uff0c\u53cd\u590d\u51fa\u73b0\u8005\u53ef\u5728\u6b62\u8840\u540e\u4e8e\u76ae\u80a4\u79d1\u5c31\u8bca\uff0c\u6216\u91c7\u53d6\u5982\u6fc0\u5149\u6216\u624b\u672f\u5207\u9664\u7b49\u5c40\u90e8\u6cbb\u7597\uff1b\u5e76\u53d1\u611f\u67d3\u8005\u5e94\u7ed9\u4e88\u6297\u611f\u67d3\u6cbb\u7597\u3002\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u53ef\u80fd\u5728\u76ae\u80a4\u4ee5\u5916\u7684\u5176\u4ed6\u7ec4\u7ec7\u53d1\u751f\uff08\u5305\u62ec\u7751\u7ed3\u819c\u3001\u5185\u5916\u7726\u3001\u53e3\u8154\u9ecf\u819c\u3001\u54bd\u5589\u7b49\u6d88\u5316\u9053\u9ecf\u819c\u6216\u5176\u4ed6\u810f\u5668\uff09\uff0c\u5fc5\u8981\u65f6\u8fdb\u884c\u76f8\u5e94\u7684\u533b\u5b66\u68c0\u67e5\uff0c\u5982\u5927\u4fbf\u6f5c\u8840\u3001\u5185\u7aa5\u955c\u53ca\u5f71\u50cf\u5b66\u68c0\u67e5\uff08\u5177\u4f53\u76f8\u5173\u5185\u5bb9\u8be6\u89c1\u300a\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u4fe1\u606f\u6536\u96c6\u53ca\u98ce\u9669\u7ba1\u7406\u8ba1\u5212\u300b\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u56db\u3001\u66ff\u96f7\u5229\u73e0\u5355\u6297<span> Tislelizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u7d2b\u6749\u9187\u548c\u5361\u94c2\u6216\u767d\u86cb\u767d\u7d2b\u6749\u9187\u548c\u5361\u94c2\u7528\u4e8e\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u9cde\u72b6<span>NSCLC<\/span>\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u94c2\u7c7b\u5316\u7597\u7528\u4e8e<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c<span>ALK<\/span>\u9634\u6027\u3001\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6<span>NSCLC<\/span>\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u91c7\u7528\u9759\u8109\u8f93\u6ce8\u7684\u65b9\u5f0f\u7ed9\u836f\uff0c\u63a8\u8350\u5242\u91cf\u4e3a<span>200mg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\u3002\u7528\u836f\u76f4\u5230\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0e\u5316\u7597\u8054\u7528\u65f6\uff0c\u82e5\u4e3a\u540c\u65e5\u7ed9\u836f\u5219\u5148\u8f93\u6ce8\u66ff\u96f7\u5229\u73e0\u5355\u6297\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u6709\u521d\u6b65\u7684\u75be\u75c5\u8fdb\u5c55\u8868\u73b0\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\uff0c\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\uff0c\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\uff0c\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e94\u3001\u4fe1\u8fea\u5229\u5355\u6297<span> Sintilimab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u94c2\u7c7b\u5316\u7597\uff0c\u7528\u4e8e\u672a\u7ecf\u7cfb\u7edf\u6cbb\u7597\u7684<span>EGFR<\/span>\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c<span>ALK<\/span>\u9634\u6027\u7684\u665a\u671f\u6216\u590d\u53d1\u6027\u975e\u9cde\u72b6\u7ec6\u80de<span>NSCLC<\/span>\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u5409\u897f\u4ed6\u6ee8\u548c\u94c2\u7c7b\u5316\u7597\uff0c\u7528\u4e8e\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u665a\u671f\u6216\u590d\u53d1\u6027\u9cde\u72b6\u7ec6\u80de<span>NSCLC<\/span>\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u91c7\u7528\u9759\u8109\u8f93\u6ce8\u7684\u65b9\u5f0f\u7ed9\u836f\uff0c\u9759\u8109\u8f93\u6ce8\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>200mg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u4ea7\u751f\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u9759\u8109\u8f93\u6ce8\u65f6\u95f4\u5e94\u5728<span>30<\/span>\uff5e<span>60<\/span>\u5206\u949f\u5185\u3002\u4e0d\u5f97\u901a\u8fc7\u9759\u8109\u63a8\u6ce8\u6216\u5355\u6b21\u5feb\u901f\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u5f71\u50cf\u5b66\u521d\u6b65\u8bc1\u636e\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\u3002\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002\u76ee\u524d\u5c1a\u65e0\u9488\u5bf9\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u6216\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u72ec\u7acb\u7814\u7a76\u6570\u636e\u3002\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u6216\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c1a\u65e0\u5728<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u53ca\u9752\u5c11\u5e74\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e\u3002\u5728\u8001\u5e74\uff08\u2265<span>65<\/span>\u5c81\uff09\u4e0e\u5e74\u8f7b\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u672a\u663e\u793a\u663e\u8457\u5dee\u5f02\u3002\u5efa\u8bae\u5728\u533b\u751f\u7684\u6307\u5bfc\u4e0b\u614e\u7528\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u5efa\u8bae\u5728\u598a\u5a20\u671f\u95f4\u4f7f\u7528\u672c\u54c1\u6cbb\u7597\u3002\u5efa\u8bae\u54fa\u4e73\u671f\u5987\u5973\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u53ca\u672b\u6b21\u7ed9\u836f\u540e\u81f3\u5c11<span>5<\/span>\u4e2a\u6708\u5185\u505c\u6b62\u54fa\u4e73\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u907f\u514d\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\uff0c\u4f46\u662f\u5982\u679c\u4e3a\u4e86\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u540e\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u516d\u3001\u4f0a\u5339\u6728\u5355\u6297 <span>Ipilimumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>50mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u8054\u5408\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u7528\u4e8e\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u3001\u521d\u6cbb\u7684\u975e\u4e0a\u76ae\u6837\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u6210\u4eba\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>1mg\/kg<\/span>\uff0c\u6bcf<span>6<\/span>\u5468\u4e00\u6b21\uff0c\u9759\u8109\u8f93\u6ce8<span>30<\/span>\u5206\u949f\uff0c\u8054\u5408<span>360mg<\/span>\u7eb3\u6b66\u5229\u5c24\u5355\u6297\uff0c\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c\u6216\u8054\u5408<span>3mg\/kg<\/span>\u7eb3\u6b66\u5229\u5c24\u5355\u6297\uff0c\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff0c\u9759\u8109\u8f93\u6ce8<span>30<\/span>\u5206\u949f\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4ea7\u751f\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\uff0c\u6216\u81f3<span>24<\/span>\u4e2a\u6708\u7684\u60a3\u8005\u6ca1\u6709\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5df2\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5bf9\u4e8e\u4e34\u5e8a\u7a33\u5b9a\u4e14\u6709\u75be\u75c5\u8fdb\u5c55\u521d\u6b65\u8bc1\u636e\u7684\u60a3\u8005\uff0c\u5efa\u8bae\u7ee7\u7eed\u4f7f\u7528\u672c\u54c1\u8054\u5408\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u5728\u57fa\u7ebf\u65f6\u548c\u6bcf\u5242\u672c\u54c1\u7ed9\u836f\u4e4b\u524d\u8bc4\u4f30\u809d\u529f\u80fd\u548c\u7532\u72b6\u817a\u529f\u80fd\u3002\u6b64\u5916\uff0c\u5728\u7528\u672c\u54c1\u6cbb\u7597\u671f\u95f4\uff0c\u5fc5\u987b\u8bc4\u4f30\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u7684\u4efb\u4f55\u4f53\u5f81\u6216\u75c7\u72b6\uff08\u5305\u62ec\u8179\u6cfb\u548c\u7ed3\u80a0\u708e\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u53ef\u4e0d\u7ecf\u7a00\u91ca\u7528\u4e8e\u9759\u8109\u8f93\u6ce8\uff0c\u6216\u8005\u91c7\u7528\u6ce8\u5c04\u7528\u6c2f\u5316\u94a0\u6eb6\u6db2\uff08<span>9mg\/ml<\/span>\uff0c<span>0.9%<\/span>\uff09\u6216\u6ce8\u5c04\u7528\u8461\u8404\u7cd6\u6eb6\u6db2\uff08<span>50mg\/ml<\/span>\uff0c<span>5%<\/span>\uff09\u7a00\u91ca\u6d53\u5ea6\u81f3<span>1<\/span>\uff5e<span>4mg\/ml<\/span>\u540e\u8f93\u6ce8\u4f7f\u7528\u3002\u672c\u54c1\u4e0d\u5f97\u4ee5\u9759\u8109\u63a8\u6ce8\u6216\u5355\u6b21\u5feb\u901f\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5f53\u4e0e\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u7528\u65f6\uff0c\u5e94\u5148\u8f93\u6ce8\u7eb3\u6b66\u5229\u5c24\u5355\u6297\uff0c\u4e4b\u540e\u540c\u4e00\u5929\u8f93\u6ce8\u672c\u54c1\u3002\u6bcf\u6b21\u8f93\u6ce8\u9700\u4f7f\u7528\u5355\u72ec\u7684\u8f93\u6db2\u888b\u548c\u8fc7\u6ee4\u5668\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u5339\u6728\u5355\u6297\u8054\u5408\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u662f\u76ae\u75b9\u3001\u75b2\u4e4f\u3001\u8179\u6cfb\u3001\u7619\u75d2\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u548c\u6076\u5fc3\u3002\u5927\u591a\u6570\u4e0d\u826f\u53cd\u5e94\u4e3a\u8f7b\u4e2d\u5ea6\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51fa\u73b0<span>4<\/span>\u7ea7\u6216\u590d\u53d1\u6027<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u6216\u8005\u867d\u7136\u8fdb\u884c\u6cbb\u7597\u8c03\u6574\u4f46\u4ecd\u6301\u7eed\u5b58\u5728\u7684<span>2<\/span>\u7ea7\u6216<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\u65f6\uff0c\u5e94\u6c38\u4e45\u6027\u505c\u6b62\u672c\u54c1\u4e0e\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u6cbb\u7597<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5f53\u672c\u54c1\u4e0e\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u7ed9\u836f\u65f6\uff0c\u82e5\u6682\u505c\u4efb\u4e00\u836f\u7269\uff0c\u5219\u5e94\u540c\u65f6\u6682\u505c\u53e6\u4e00\u836f\u7269\u3002\u82e5\u5728\u6682\u505c\u540e\u91cd\u65b0\u5f00\u59cb\u7ed9\u836f\uff0c\u5219\u5e94\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u8bc4\u4f30\u60c5\u51b5\u91cd\u65b0\u5f00\u59cb\u8054\u5408\u6cbb\u7597\u6216\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u5355\u836f\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7f8e\u56fd<span>FDA<\/span>\u548c\u6b27\u76df<span>EMA<\/span>\u6279\u51c6\u4f0a\u5339\u6728\u5355\u6297\u8054\u5408\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u665a\u671f\u548c\u8f6c\u79fb\u6027<span>NSCLC<\/span>\uff0c\u8be6\u89c1\u201c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u201d\u5408\u7406\u7528\u836f\u8981\u70b9\u7b2c<span>18<\/span>\u6761\u3002<span><\/span><\/span>\n<\/p>\n<p><b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><br \/>\n<\/span><\/b> <\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6d88\u5316\u7cfb\u7edf\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e00\u3001<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7d22\u62c9\u975e\u5c3c<span> Sorafenib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">200mg<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u65e0\u6cd5\u624b\u672f\u6216\u8fdc\u5904\u8f6c\u79fb\u7684\u809d\u7ec6\u80de\u764c\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u6709\u8179\u6cfb\u3001\u4e4f\u529b\u3001\u8131\u53d1\u3001\u611f\u67d3\u3001\u624b\u8db3\u76ae\u80a4\u53cd\u5e94\u3001\u76ae\u75b9\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u670d\u7528\u5242\u91cf\u4e3a<span>0.4g<\/span><\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\/<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b21<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u7a7a\u8179\u6216\u4f34\u4f4e\u8102\u3001\u4e2d\u8102\u996e\u98df\u670d\u7528\uff0c\u5fc5\u987b\u6574\u7247\u541e\u670d\uff0c\u5982\u679c\u6f0f\u670d\u6216\u5455\u5410\u540c\u4e00\u5929\u5185\u4e0d\u5f97\u8865\u670d\u3002\u5bf9\u7591\u4f3c\u4e0d\u826f\u53cd\u5e94\u7684\u5904\u7406\u5305\u62ec\u6682\u505c\u6216\u51cf\u5c11\u7528\u91cf\uff0c\u5982\u9700\u51cf\u5c11\u5242\u91cf\uff0c\u7d22\u62c9\u975e\u5c3c\u7684\u5242\u91cf\u51cf\u4e3a\u6bcf\u5929\u4e00\u6b21\uff0c<span>0.4g<\/span><\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\/<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b21<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u53e3\u670d\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0e\u901a\u8fc7<span>UGT1A1<\/span>\u9014\u5f84\u4ee3\u8c22<span>\/<\/span>\u6e05\u9664\u7684\u836f\u7269\uff08\u5982\u4f0a\u7acb\u66ff\u5eb7\u3001\u591a\u897f\u4ed6\u8d5b\uff09\u8054\u5408\u5e94\u7528\u65f6\u9700\u8c28\u614e\u3002\u4e0e\u534e\u6cd5\u6797\u5408\u7528\u65f6\u5e94\u5b9a\u671f\u68c0\u6d4b<span>INR<\/span>\u503c\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u7f3a\u4e4f\u5728\u665a\u671f\u809d\u7ec6\u80de\u764c\u60a3\u8005\u4e2d\u7d22\u62c9\u975e\u5c3c\u4e0e\u4ecb\u5165\u6cbb\u7597\u5982\u809d\u52a8\u8109\u6813\u585e\u5316\u7597\uff08<span>TACE<\/span>\uff09\u6bd4\u8f83\u7684\u968f\u673a\u5bf9\u7167\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff0c\u56e0\u6b64\u5c1a\u4e0d\u80fd\u660e\u786e\u672c\u54c1\u76f8\u5bf9\u4ecb\u5165\u6cbb\u7597\u7684\u4f18\u52a3\uff0c\u4e5f\u4e0d\u80fd\u660e\u786e\u5bf9\u65e2\u5f80\u63a5\u53d7\u8fc7\u4ecb\u5165\u6cbb\u7597\u540e\u60a3\u8005\u4f7f\u7528\u7d22\u62c9\u975e\u5c3c\u662f\u5426\u6709\u76ca\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.TACTICS<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7814\u7a76\uff08<span>NCT01217034<\/span>\uff09\u8bc1\u5b9e\u9996\u6b21<span>TACE<\/span>\u8054\u5408\u7d22\u62c9\u975e\u5c3c\u8f83\u7d22\u62c9\u975e\u5c3c\u7ec4\u83b7\u76ca\u66f4\u4f73\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u745e\u6208\u975e\u5c3c<span> Regorafenib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>40mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u63a5\u53d7\u8fc7\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u7684\u809d\u7ec6\u80de\u764c\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u63a5\u53d7\u8fc7\u4f0a\u9a6c\u66ff\u5c3c\u53ca\u8212\u5c3c\u66ff\u5c3c\u6cbb\u7597\u7684\u5c40\u90e8\u665a\u671f\u7684\u3001\u65e0\u6cd5\u624b\u672f\u5207\u9664\u7684\u6216\u8f6c\u79fb\u6027\u80c3\u80a0\u95f4\u8d28\u7624\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u63a5\u53d7\u8fc7\u6c1f\u5c3f\u5627\u5576\u3001\u5965\u6c99\u5229\u94c2\u548c\u4f0a\u7acb\u66ff\u5eb7\u4e3a\u57fa\u7840\u7684\u5316\u7597\uff0c\u4ee5\u53ca\u65e2\u5f80\u63a5\u53d7\u8fc7\u6216\u4e0d\u9002\u5408\u63a5\u53d7\u6297<span>VEGF<\/span>\u6cbb\u7597\u3001\u6297<span>EGFR<\/span>\u6cbb\u7597\uff08<span>RAS<\/span>\u91ce\u751f\u578b\uff09\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u65e0\u9700\u8fdb\u884c\u57fa\u56e0\u68c0\u6d4b\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u836f\u54c1\u8bf4\u660e\u4e66\u63a8\u8350\u5242\u91cf\u4e3a<span>160mg<\/span>\u53e3\u670d\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u5efa\u8bae\u4e0e\u98df\u7269\u540c\u670d\uff0c\u7528\u836f<span>3<\/span>\u5468\u505c\u836f<span>1<\/span>\u5468\u3002\u57fa\u4e8e\u4e2a\u4eba\u7684\u5b89\u5168\u53ca\u8010\u53d7\u6027\u8003\u8651\uff0c\u53ef\u80fd\u9700\u8981\u4e2d\u65ad\u6216\u964d\u4f4e\u5242\u91cf\uff0c\u4e5f\u53ef\u4ee5\u8003\u8651\u91c7\u7528<span>80<\/span>\uff5e<span>120mg<\/span>\u8d77\u59cb\u5242\u91cf\u9010\u6e10\u9012\u589e\u3002\u5fc5\u987b\u6574\u7247\u541e\u670d\uff0c\u5982\u679c\u6f0f\u670d\u6216\u5455\u5410\u540c\u4e00\u5929\u5185\u4e0d\u5f97\u8865\u670d\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e9a\u6d32\u4eba\u7fa4\u6700\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u4e3a\u624b\u8db3\u76ae\u80a4\u53cd\u5e94\u3001\u809d\u529f\u80fd\u5f02\u5e38\uff08\u9ad8\u80c6\u7ea2\u7d20\u8840\u75c7\u3001<span>ALT<\/span>\u5347\u9ad8\u3001<span>AST<\/span>\u5347\u9ad8\uff09\u548c\u9ad8\u8840\u538b\uff0c\u540c\u65f6\uff0c\u8fd8\u8981\u6ce8\u610f\u75bc\u75db\u3001\u4e4f\u529b\u3001\u8179\u6cfb\u3001\u98df\u6b32\u4e0b\u964d\u53ca\u8fdb\u98df\u51cf\u5c11\u7b49\u4e0d\u826f\u53cd\u5e94\uff1b\u6700\u4e25\u91cd\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u3001\u51fa\u8840\u3001\u80c3\u80a0\u9053\u7a7f\u5b54\u53ca\u611f\u67d3\uff1b\u6709\u8840\u6813\u3001\u6813\u585e\u75c5\u53f2\u8005\u5e94\u8c28\u614e\u4f7f\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u745e\u6208\u975e\u5c3c\u4efb\u4e00\u6d3b\u6027\u7269\u8d28\u6216\u8f85\u6599\u6709\u8d85\u654f\u53cd\u5e94\u7684\u60a3\u8005\u7981\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u8054\u7528<span>CYP3A4<\/span>\u5f3a\u6548\u6291\u5236\u5242\u548c\u8bf1\u5bfc\u5242\uff0c\u8054\u7528\u4f0a\u7acb\u66ff\u5eb7\u53ef\u80fd\u589e\u52a0<span>UGT1A1<\/span>\u548c<span>UGT1A9<\/span>\u5e95\u7269\u7684\u5168\u8eab\u66b4\u9732\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e09\u3001\u4ed1\u4f10\u66ff\u5c3c<span> Lenvatinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>4mg<\/span>\u3001<span>10mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u5168\u8eab\u7cfb\u7edf\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u6709\u9ad8\u8840\u538b\u3001\u75b2\u4e4f\u3001\u8179\u6cfb\u3001\u98df\u6b32\u4e0b\u964d\u3001\u4f53\u91cd\u964d\u4f4e\u3001\u5173\u8282\u75db<span>\/<\/span>\u808c\u75db\u3001\u8179\u75db\u3001\u638c\u8dd6\u7ea2\u80bf\u7efc\u5408\u5f81\u3001\u86cb\u767d\u5c3f\u3001\u51fa\u8840\u4e8b\u4ef6\u3001\u53d1\u97f3\u56f0\u96be\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u75c7\u3001\u6076\u5fc3\uff0c\u4e25\u91cd\u7684\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u809d\u8870\u7aed\u3001\u8111\u51fa\u8840\u3001\u547c\u5438\u8870\u7aed\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e0e\u7532\u72b6\u817a\u764c\u548c\u80be\u764c\u4e0d\u540c\uff0c\u4ed1\u4f10\u66ff\u5c3c\u5728\u809d\u764c\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u5728\u4e34\u5e8a\u4e0a\u53d7\u5230\u4f53\u91cd\u7684\u663e\u8457\u5f71\u54cd\uff1a\u5bf9\u4e8e\u4f53\u91cd\uff1c<span>60kg<\/span>\u7684\u60a3\u8005\uff0c\u63a8\u8350\u65e5\u5242\u91cf\u4e3a<span>8mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff1b\u5bf9\u4e8e\u4f53\u91cd\uff1e<span>60kg<\/span>\u7684\u60a3\u8005\uff0c\u63a8\u8350\u65e5\u5242\u91cf\u4e3a<span>12mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4ed1\u4f10\u66ff\u5c3c\u5e94\u5728\u6bcf\u5929\u56fa\u5b9a\u65f6\u95f4\u670d\u7528\uff0c\u7a7a\u8179\u6216\u4e0e\u98df\u7269\u540c\u670d\u5747\u53ef\u3002\u5982\u679c\u60a3\u8005\u9057\u6f0f\u4e00\u6b21\u7528\u836f\u4e14\u65e0\u6cd5\u5728<span>12<\/span>\u5c0f\u65f6\u5185\u670d\u7528\uff0c\u65e0\u9700\u8865\u670d\uff0c\u5e94\u6309\u5e38\u89c4\u7528\u836f\u65f6\u95f4\u8fdb\u884c\u4e0b\u4e00\u6b21\u670d\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u56db\u3001\u591a\u7eb3\u975e\u5c3c<span>Donafenib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>0.1g<\/span><\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u5168\u8eab\u7cfb\u7edf\u6027\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a <span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u6709\u624b\u8db3\u76ae\u80a4\u53cd\u5e94\u3001\u8179\u6cfb\u3001\u8840\u5c0f\u677f\u8ba1\u6570\u51cf\u5c11\u3001\u9ad8\u8840\u538b\u3001\u5929\u95e8\u51ac\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\u5347\u9ad8\u3001\u8131\u53d1\u3001\u76ae\u75b9\u548c\u86cb\u767d\u5c3f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u6b21<span>0.2g<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u7a7a\u8179\u53e3\u670d\uff0c\u4ee5\u6e29\u5f00\u6c34\u541e\u670d\u3002\u5efa\u8bae\u6bcf\u5929\u540c\u4e00\u65f6\u6bb5\u670d\u836f\uff0c\u5982\u679c\u6f0f\u670d\u836f\u7269\uff0c\u65e0\u9700\u8865\u670d\uff0c\u5e94\u6309\u5e38\u89c4\u7528\u836f\u65f6\u95f4\u8fdb\u884c\u4e0b\u4e00\u6b21\u670d\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u4f53\u5916\u7814\u7a76\u63d0\u793a\uff0c\u591a\u7eb3\u975e\u5c3c\u4e3b\u8981\u901a\u8fc7<span>CYP3A4<\/span>\u548c<span>UGTIA9<\/span>\u4ee3\u8c22\uff0c\u6b64\u5916<span>CYP1B1<\/span>\u3001<span>CYP2C8<\/span>\u3001<span>CYP2C9<\/span>\u3001<span>CYP2C19<\/span>\u3001<span>CYP2D6<\/span>\u548c<span>CYP3A5<\/span>\u4e5f\u90e8\u5206\u53c2\u4e0e\u591a\u7eb3\u975e\u5c3c\u7684\u4ee3\u8c22\u3002\u8054\u7528\u76f8\u5173\u4ee3\u8c22\u9176\u7684\u6291\u5236\u5242\u6216\u8bf1\u5bfc\u5242\u65f6\u5e94\u5f53\u8c28\u614e\u3002<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e94\u3001\u963f\u66ff\u5229\u73e0\u5355\u6297<span> Atezolizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>1200mg<\/span>\uff08<span>20ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u66ff\u5229\u73e0\u5355\u6297\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u5168\u8eab\u7cfb\u7edf\u6027\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u66ff\u5229\u73e0\u5355\u6297\u4e0e\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408\u7528\u836f\u57fa\u4e8e<span>IMbrave150<\/span>\u7814\u7a76\uff1a\u9996\u5148\u9759\u8109\u8f93\u6ce8\u963f\u66ff\u5229\u73e0\u5355\u6297\uff0c\u63a8\u8350\u5242\u91cf\u4e3a<span>1200mg<\/span>\uff0c\u7ee7\u4e4b\u4ee5\u9759\u8109\u8f93\u6ce8\u8d1d\u4f10\u73e0\u5355\u6297<span>15mg\/kg<\/span>\u3002\u8be5\u65b9\u6848\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\u3002\u9996\u6b21\u7ed9\u836f\u81f3\u5c11\u6301\u7eed<span>60<\/span>\u5206\u949f\uff0c\u540e\u7eed\u53ef\u81f3\u5c11<span>30<\/span>\u5206\u949f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u60a3\u8005\u53ef\u63a5\u53d7\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u76f4\u81f3\u65e0\u4e34\u5e8a\u83b7\u76ca\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u4f46\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\u3002\u5e94\u5bf9\u75be\u75c5\u8fdb\u5c55\u540e\u7ee7\u7eed\u4f7f\u7528\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u5f00\u5c55\u5bc6\u5207\u76d1\u6d4b\uff0c<span>4<\/span>\uff5e<span>8<\/span>\u5468\u5185\u91cd\u590d\u80bf\u7624\u7597\u6548\u8bc4\u4f30\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u6cbb\u7597\u524d\u8fdb\u884c\u5305\u62ec\u7532\u72b6\u817a\u529f\u80fd\u3001\u5fc3\u808c\u9176\u7b49\u7684\u57fa\u7ebf\u68c0\u6d4b\uff0c\u5728\u6cbb\u7597\u4e2d\u5b9a\u671f\u968f\u8bbf\u7528\u4e8e\u65e9\u671f\u53d1\u73b0\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u540c\u65f6\u9700\u6ce8\u610f\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u4e5f\u53ef\u80fd\u51fa\u73b0\u4e8e\u6cbb\u7597\u7ed3\u675f\u540e\u3002\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u6839\u636e\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u7684\u7c7b\u578b\u548c\u4e25\u91cd\u7a0b\u5ea6\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\uff0c\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002\u4e25\u91cd\u8005\u6216\u8bca\u65ad\u5b58\u7591\u8005\u53ef\u7531\u6d88\u5316\u79d1\u3001\u98ce\u6e7f\u79d1\u3001\u76ae\u80a4\u79d1\u3001\u547c\u5438\u79d1\u3001\u80bf\u7624\u79d1\u7b49\u7ec4\u6210\u7684\u514d\u75ab\u4e0d\u826f\u53cd\u5e94\u591a\u5b66\u79d1\u7efc\u5408\u6cbb\u7597\uff08<span>MDT<\/span>\uff09\u8fdb\u884c\u4f1a\u8bca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u4f7f\u7528\u672c\u54c1\u4e4b\u524d\u5e94\u5c3d\u91cf\u907f\u514d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u836f\u7269\u53ef\u80fd\u4f1a\u5f71\u54cd\u672c\u54c1\u7684\u836f\u6548\u5b66\u6d3b\u6027\u53ca\u7597\u6548\u3002\u4f46\u5728\u672c\u54c1\u5f00\u59cb\u7ed9\u836f\u540e\uff0c\u53ef\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u3002\u5728\u60a3\u8005\u63a5\u53d7\u514d\u75ab\u6291\u5236\u5242\u91cf\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u671f\u95f4\uff0c\u4e0d\u5efa\u8bae\u91cd\u65b0\u4f7f\u7528\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c1a\u672a\u786e\u7acb\u963f\u66ff\u5229\u73e0\u5355\u6297\u5728<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u548c\u9752\u5c11\u5e74\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u8001\u5e74\u60a3\u8005\uff08\u2265<span>65<\/span>\u5c81\uff09\u3001\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u3001\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u5728\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u3001\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u4f7f\u7528\u7684\u5b89\u5168\u6027\u53ca\u6709\u6548\u6027\u5c1a\u672a\u5efa\u7acb\uff0c\u5982\u7ecf\u533b\u5e08\u8bc4\u4f30\u4f7f\u7528\u672c\u54c1\u9884\u671f\u83b7\u76ca\u5927\u4e8e\u98ce\u9669\uff0c\u9700\u5728\u533b\u5e08\u6307\u5bfc\u4e0b\u8c28\u614e\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u516d\u3001\u4fe1\u8fea\u5229\u5355\u6297<span> Sintilimab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u9002\u7528\u4e8e\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u7528\u4e8e\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u809d\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u8be5\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\u8bc4\u4f30\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u53cd\u5e94\u53ca\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u57fa\u4e8e<span>ORIENT-32<\/span>\u4e34\u5e8a\u7814\u7a76\uff0c\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\uff0c\u91c7\u7528\u9759\u8109\u8f93\u6ce8\u7684\u65b9\u5f0f\u7ed9\u836f\uff0c\u9759\u8109\u8f93\u6ce8\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>200mg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u6cbb\u7597\u524d\u8fdb\u884c\u5305\u62ec\u7532\u72b6\u817a\u529f\u80fd\u3001\u5fc3\u808c\u9176\u7b49\u7684\u57fa\u7ebf\u68c0\u6d4b\uff0c\u5728\u6cbb\u7597\u4e2d\u5b9a\u671f\u968f\u8bbf\u7528\u4e8e\u65e9\u671f\u53d1\u73b0\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u540c\u65f6\u9700\u6ce8\u610f\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u4e5f\u53ef\u80fd\u51fa\u73b0\u4e8e\u6cbb\u7597\u7ed3\u675f\u540e\u3002\u5982\u51fa\u73b0\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\u3002\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002\u4e25\u91cd\u8005\u6216\u8bca\u65ad\u5b58\u7591\u8005\u53ef\u7531\u6d88\u5316\u79d1\u3001\u98ce\u6e7f\u79d1\u3001\u76ae\u80a4\u79d1\u3001\u547c\u5438\u79d1\u3001\u80bf\u7624\u79d1\u7b49\u7ec4\u6210\u7684\u514d\u75ab\u4e0d\u826f\u53cd\u5e94<span>MDT<\/span>\u8fdb\u884c\u4f1a\u8bca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u672c\u54c1\u5c1a\u65e0\u9488\u5bf9\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\uff1b\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u672c\u54c1\u5c1a\u65e0\u9488\u5bf9\u4e2d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u8f7b\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\uff1b\u4e2d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u7684\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u2265<span>10%<\/span>\uff09\u5305\u62ec\u53d1\u70ed\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u75c7\u3001\u4f53\u91cd\u589e\u52a0\u3001\u80ba\u708e\u3001\u4e0a\u547c\u5438\u9053\u611f\u67d3\u3001\u76ae\u75b9\u3001\u8d2b\u8840\u3001\u54b3\u55fd\u3002\u6700\u5e38\u89c1\u7684<span>3<\/span>\u7ea7\u4ee5\u4e0a\u7684\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u4f53\u91cd\u589e\u52a0\u3001\u8d2b\u8840\u3001\u8f93\u6db2\u53cd\u5e94\u3001\u547c\u5438\u9053\u611f\u67d3\u3001\u611f\u67d3\u6027\u80ba\u708e\u3001\u514d\u75ab\u76f8\u5173\u6027\u80ba\u708e\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5c1a\u65e0\u5728<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u53ca\u9752\u5c11\u5e74\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5728\u2265<span>65<\/span>\u5c81\u7684\u8001\u5e74\u60a3\u8005\u4e2d\u5e94\u7528\u6570\u636e\u6709\u9650\uff0c\u5efa\u8bae\u5728\u533b\u751f\u7684\u6307\u5bfc\u4e0b\u614e\u7528\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u5efa\u8bae\u5728\u598a\u5a20\u671f\u95f4\u4f7f\u7528\u672c\u54c1\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56e0\u53ef\u80fd\u5e72\u6270\u672c\u54c1\u836f\u6548\u5b66\u6d3b\u6027\uff0c\u5e94\u907f\u514d\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002\u4f46\u662f\u5982\u679c\u4e3a\u4e86\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u540e\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span style=\"color:red;\"><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e03\u3001\u5361\u745e\u5229\u73e0\u5355\u6297<span> Camrelizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7c89\u9488\u5242\uff1a<span>200mg\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e00\u7ebf\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u60a3\u8005\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u63a5\u53d7\u8fc7\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u548c<span>\/<\/span>\u6216\u542b\u5965\u6c99\u5229\u94c2\u7cfb\u7edf\u5316\u7597\u7684\u665a\u671f\u809d\u7ec6\u80de\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u91c7\u7528\u9759\u8109\u8f93\u6ce8\u7684\u65b9\u5f0f\u7ed9\u836f\uff0c\u9759\u8109\u8f93\u6ce8\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>200mg<\/span>\uff0c\u6bcf<span>2<\/span>\u5468\u6216<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53ea\u8981\u89c2\u5bdf\u5230\u4e34\u5e8a\u83b7\u76ca\uff0c\u5e94\u7ee7\u7eed<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5361\u745e\u5229\u73e0\u5355\u6297<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\uff0c\u76f4\u81f3\u60a3\u8005\u4e0d\u80fd\u8010\u53d7\uff0c<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5373\u4f7f\u8003\u8651\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u53ef\u80fd\uff0c\u4f46<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u60a3\u8005\u4e2a\u4f53\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u7684\u7a0b\u5ea6\u4e0d\u540c\uff0c\u53ef\u6682\u505c\u7ed9\u836f\u6216\u505c\u836f\uff0c\u4e0d\u5efa\u8bae\u5242\u91cf\u8c03\u6574\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u6cbb\u7597\u524d\u8fdb\u884c\u5305\u62ec\u7532\u72b6\u817a\u529f\u80fd\u3001\u5fc3\u808c\u9176\u7b49\u7684\u57fa\u7ebf\u68c0\u6d4b\uff0c\u5728\u6cbb\u7597\u4e2d\u5b9a\u671f\u968f\u8bbf\u7528\u4e8e\u65e9\u671f\u53d1\u73b0\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u3002\u540c\u65f6\u9700\u6ce8\u610f\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u4e5f\u53ef\u80fd\u51fa\u73b0\u4e8e\u6cbb\u7597\u7ed3\u675f\u540e\u3002\u5982\u51fa\u73b0\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\u3002\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002\u53d1\u751f<span>4<\/span>\u7ea7\u6216\u590d\u53d1\u6027<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u867d\u7136\u8fdb\u884c\u6cbb\u7597\u8c03\u6574\u4f46\u4ecd\u6301\u7eed\u5b58\u5728<span>2<\/span>\u7ea7\u6216<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u6c38\u4e45\u6027\u505c\u7528\u5361\u745e\u5229\u73e0\u5355\u6297\u3002\u4e25\u91cd\u8005\u6216\u8bca\u65ad\u5b58\u7591\u8005\u53ef\u7531\u6d88\u5316\u79d1\u3001\u98ce\u6e7f\u79d1\u3001\u76ae\u80a4\u79d1\u3001\u547c\u5438\u79d1\u3001\u80bf\u7624\u79d1\u7b49\u7ec4\u6210\u7684\u514d\u75ab\u4e0d\u826f\u53cd\u5e94<span>MDT<\/span>\u8fdb\u884c\u4f1a\u8bca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5728\u2265<span>65<\/span>\u5c81\u7684\u8001\u5e74\u60a3\u8005\u4e2d\u5e94\u7528\u6570\u636e\u6709\u9650\uff0c\u5efa\u8bae\u5728\u533b\u5e08\u7684\u6307\u5bfc\u4e0b\u614e\u7528\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002\u4e0d\u5efa\u8bae\u5728\u598a\u5a20\u671f\u95f4\u4f7f\u7528\u672c\u54c1\u6cbb\u7597\u3002\u76ee\u524d\u672c\u54c1\u5c1a\u65e0\u9488\u5bf9\u4e2d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u4e2d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\uff0c\u8f7b\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u5e08\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002\u76ee\u524d\u672c\u54c1\u5c1a\u65e0\u9488\u5bf9\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\uff0c\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u4f7f\u7528\u672c\u54c1\u4e4b\u524d\u5e94\u907f\u514d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u836f\u7269\u53ef\u80fd\u4f1a\u5f71\u54cd\u672c\u54c1\u7684\u836f\u6548\u5b66\u6d3b\u6027\u53ca\u7597\u6548\u3002\u4f46\u5728\u672c\u54c1\u5f00\u59cb\u7ed9\u836f\u540e\uff0c\u53ef\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u514d\u75ab\u4ecb\u5bfc\u6027\u4e0d\u826f\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u7684\u5904\u7406\uff1a\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c<span>70%<\/span>\uff5e<span>80%<\/span>\u53d1\u751f\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u3002\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\uff0c\u5927\u591a\u53d1\u751f\u5728\u4f53\u8868\u76ae\u80a4\uff0c\u5c11\u6570\u53ef\u89c1\u4e8e\u53e3\u8154\u9ecf\u819c\u3001\u9f3b\u8154\u9ecf\u819c\u4ee5\u53ca\u773c\u7751\u7ed3\u819c\u3002\u53d1\u751f\u4e8e\u76ae\u80a4\u7684\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\uff0c\u521d\u59cb\u591a\u8868\u73b0\u4e3a\u4f53\u8868\u9c9c\u7ea2\u8272\u70b9\u72b6\u7269\uff0c\u76f4\u5f84\u2264<span>2mm<\/span>\uff0c\u968f\u7740\u7528\u836f\u6b21\u6570\u589e\u52a0\uff0c\u75c5\u53d8\u8303\u56f4\u53ef\u9010\u6e10\u589e\u5927\uff0c\u591a\u4e3a\u7ed3\u8282\u72b6\uff0c\u4e5f\u6709\u6591\u7247\u72b6\uff0c\u989c\u8272\u9c9c\u7ea2\u6216\u6697\u7ea2\uff0c\u9700\u89c2\u5bdf\u4e34\u5e8a\u75c7\u72b6\u548c\u4f53\u5f81\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5f53\u60a3\u8005\u51fa\u73b0\u8be5\u4e0d\u826f\u53cd\u5e94\u65f6\uff0c\u5e94\u907f\u514d\u6293\u6320\u6216\u6469\u64e6\uff0c\u6613\u6469\u64e6\u90e8\u4f4d\u53ef\u7528\u7eb1\u5e03\u4fdd\u62a4\u4ee5\u907f\u514d\u51fa\u8840\uff0c\u540c\u65f6\u5e94\u8054\u7cfb\u4e3b\u7ba1\u533b\u5e08\uff0c\u83b7\u5f97\u6070\u5f53\u7684\u5904\u7406\u5efa\u8bae\u3002\u7834\u6e83\u51fa\u8840\u8005\u53ef\u91c7\u7528\u5c40\u90e8\u538b\u8feb\u6b62\u8840\uff0c\u6216\u91c7\u53d6\u5982\u6fc0\u5149\u6216\u624b\u672f\u5207\u9664\u7b49\u5c40\u90e8\u6cbb\u7597\uff1b\u5e76\u53d1\u611f\u67d3\u8005\u5e94\u7ed9\u4e88\u6297\u611f\u67d3\u6cbb\u7597\u3002\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u53ef\u80fd\u5728\u76ae\u80a4\u4ee5\u5916\u7684\u5176\u4ed6\u7ec4\u7ec7\u53d1\u751f\uff08\u5305\u62ec\u7751\u7ed3\u819c\u3001\u5185\u5916\u7726\u3001\u53e3\u8154\u9ecf\u819c\u3001\u54bd\u5589\u7b49\u9ecf\u819c\u6216\u5176\u4ed6\u810f\u5668\uff09\uff0c\u5e94\u6839\u636e\u81ea\u67e5\u75c7\u72b6\u548c\u4f53\u5f81\uff0c\u5fc5\u8981\u65f6\u8fdb\u884c\u76f8\u5e94\u7684\u533b\u5b66\u68c0\u67e5\uff0c\u5982\u5927\u4fbf\u6f5c\u8840\u3001\u5185\u7aa5\u955c\u53ca\u5f71\u50cf\u5b66\u68c0\u67e5\uff08\u5177\u4f53\u76f8\u5173\u5185\u5bb9\u8be6\u89c1\u300a\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u4fe1\u606f\u6536\u96c6\u53ca\u98ce\u9669\u7ba1\u7406\u8ba1\u5212\u300b\uff09\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u516b\u3001\u66ff\u96f7\u5229\u73e0\u5355\u6297<span>Tislelizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u81f3\u5c11\u7ecf\u8fc7\u4e00\u79cd\u5168\u8eab\u6cbb\u7597\u7684\u809d\u7ec6\u80de\u764c\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u8be5\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\u8bc4\u4f30\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u53cd\u5e94\u53ca\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u91c7\u7528\u9759\u8109\u8f93\u6ce8\u7684\u65b9\u5f0f\u7ed9\u836f\uff0c\u9759\u8109\u8f93\u6ce8\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>200mg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u9002\u5e94\u8bc1\u662f\u57fa\u4e8e\u4e00\u9879\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\u548c\u603b\u751f\u5b58\u671f\u7ed3\u679c\u7ed9\u4e88\u7684\u9644\u6761\u4ef6\u6279\u51c6\u3002\u672c\u9002\u5e94\u8bc1\u7684\u5b8c\u5168\u6279\u51c6\u5c06\u53d6\u51b3\u4e8e\u6b63\u5728\u5f00\u5c55\u4e2d\u7684\u786e\u8bc1\u6027\u968f\u673a\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\u80fd\u5426\u8bc1\u5b9e\u672c\u54c1\u6cbb\u7597\u76f8\u5bf9\u5e94\u6807\u51c6\u6cbb\u7597\u7684\u663e\u8457\u4e34\u5e8a\u83b7\u76ca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u6cbb\u7597\u524d\u8fdb\u884c\u5305\u62ec\u7532\u72b6\u817a\u529f\u80fd\u3001\u5fc3\u808c\u9176\u7b49\u7684\u57fa\u7ebf\u68c0\u6d4b\uff0c\u5728\u6cbb\u7597\u4e2d\u5b9a\u671f\u968f\u8bbf\u7528\u4e8e\u65e9\u671f\u53d1\u73b0\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u3002\u540c\u65f6\u9700\u6ce8\u610f\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u4e5f\u53ef\u80fd\u51fa\u73b0\u4e8e\u6cbb\u7597\u7ed3\u675f\u540e\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\uff0c\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\u3002\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002\u4e25\u91cd\u8005\u6216\u8bca\u65ad\u5b58\u7591\u8005\u53ef\u7531\u6d88\u5316\u79d1\u3001\u98ce\u6e7f\u79d1\u3001\u76ae\u80a4\u79d1\u3001\u547c\u5438\u79d1\u3001\u80bf\u7624\u79d1\u7b49\u7ec4\u6210\u7684\u514d\u75ab\u4e0d\u826f\u53cd\u5e94<span>MDT<\/span>\u8fdb\u884c\u4f1a\u8bca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u5c1a\u65e0\u9488\u5bf9\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u5c1a\u65e0\u9488\u5bf9\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u54fa\u4e73\u671f\u5987\u5973\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u53ca\u672b\u6b21\u7ed9\u836f\u540e\u81f3\u5c11<span>5<\/span>\u4e2a\u6708\u5185\u505c\u6b62\u54fa\u4e73\u3002\u80b2\u9f84\u671f\u5987\u5973\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u671f\u95f4\uff0c\u4ee5\u53ca\u6700\u540e\u4e00\u6b21\u672c\u54c1\u7ed9\u836f\u540e\u81f3\u5c11<span>5<\/span>\u4e2a\u6708\u5185\u5e94\u91c7\u7528\u6709\u6548\u907f\u5b55\u63aa\u65bd\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56e0\u53ef\u80fd\u5e72\u6270\u672c\u54c1\u836f\u6548\u5b66\u6d3b\u6027\uff0c\u5e94\u907f\u514d\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002\u4f46\u662f\u5982\u679c\u4e3a\u4e86\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u540e\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e5d\u3001\u5e15\u535a\u5229\u73e0\u5355\u6297<span> Pembrolizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>4ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7531\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u8bc4\u4f30\u4e3a<span>PD-L1<\/span>\u7efc\u5408\u9633\u6027\u8bc4\u5206\uff08<span>CPS<\/span>\uff09\u2265<span>10<\/span>\u3001\u65e2\u5f80\u4e00\u7ebf\u5168\u8eab\u6cbb\u7597\u5931\u8d25\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.KRAS<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u3001<span>NRAS<\/span>\u548c<span>BRAF<\/span>\u57fa\u56e0\u5747\u4e3a\u91ce\u751f\u578b\uff0c\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ad8\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\uff08<span>MSI-H<\/span>\uff09\u6216\u9519\u914d\u4fee\u590d\u57fa\u56e0\u7f3a\u9677\u578b\uff08<span>dMMR<\/span>\uff09\u7ed3\u76f4\u80a0\u764c\uff08<span>CRC<\/span>\uff09\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u57fa\u4e8e<span>KEYNOTE-181<\/span>\u548c<span>KEYNOTE-177<\/span>\u7814\u7a76\u7ed3\u679c\uff0c<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u83b7\u6279\u7684\u5242\u91cf<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u662f<span>200mg<\/span>\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6216<span>400mg<\/span>\u6bcf<span>6<\/span>\u5468\u4e00\u6b21\uff0c\u901a\u8fc7\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\uff0c\u6bcf\u6b21\u6301\u7eed\u81f3\u5c11<span>30<\/span>\u5206\u949f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53ea\u8981\u89c2\u5bdf\u5230\u4e34\u5e8a\u83b7\u76ca\uff0c\u5e94\u7ee7\u7eed<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\uff0c\u76f4\u81f3\u60a3\u8005\u4e0d\u80fd\u8010\u53d7\uff0c<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\uff0c<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5373\u4f7f\u8003\u8651\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u53ef\u80fd\uff0c\u4f46<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u505c\u836f\uff0c\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53d1\u751f<span>4<\/span>\u7ea7\u6216\u590d\u53d1\u6027<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u867d\u7136\u8fdb\u884c\u6cbb\u7597\u8c03\u6574\u4f46\u4ecd\u6301\u7eed\u5b58\u5728<span>2<\/span>\u7ea7\u6216<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u6c38\u4e45\u6027\u505c\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u3002\u5982\u679c\u51fa\u73b0\u4efb\u4f55\u91cd\u5ea6\u3001\u590d\u53d1\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u4ee5\u53ca\u4efb\u4f55\u5371\u53ca\u751f\u547d\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5fc5\u987b\u6c38\u4e45\u505c\u6b62\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8001\u5e74\u60a3\u8005\uff08\u2265<span>65<\/span>\u5c81\uff09\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u6570\u636e\u6709\u9650\u3002\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u5c1a\u672a\u5728\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u8fdb\u884c\u672c\u54c1\u7684\u76f8\u5173\u7814\u7a76\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u4f7f\u7528\u672c\u54c1\u4e4b\u524d\u5e94\u907f\u514d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u836f\u7269\u53ef\u80fd\u4f1a\u5f71\u54cd\u672c\u54c1\u7684\u836f\u6548\u5b66\u6d3b\u6027\u53ca\u7597\u6548\u3002\u4f46\u5728\u672c\u54c1\u5f00\u59cb\u7ed9\u836f\u540e\uff0c\u53ef\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u514d\u75ab\u4ecb\u5bfc\u6027\u4e0d\u826f\u53cd\u5e94\u3002\u5728\u60a3\u8005\u63a5\u53d7\u514d\u75ab\u6291\u5236\u5242\u91cf\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u671f\u95f4\uff0c\u4e0d\u53ef\u91cd\u65b0\u4f7f\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u53ef\u80fd\u5f15\u8d77\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5efa\u8bae\u6cbb\u7597\u524d\u8fdb\u884c\u5305\u62ec\u7532\u72b6\u817a\u529f\u80fd\u3001\u5fc3\u808c\u9176\u7b49\u7684\u57fa\u7ebf\u68c0\u6d4b\uff0c\u5728\u6cbb\u7597\u4e2d\u5b9a\u671f\u968f\u8bbf\u7528\u4e8e\u65e9\u671f\u53d1\u73b0\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u3002\u56e0\u4e3a\u4e0d\u826f\u53cd\u5e94\u53ef\u80fd\u5728\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u671f\u95f4\u6216\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u505c\u6b62\u540e\u7684\u4efb\u4f55\u65f6\u95f4\u53d1\u751f\uff0c\u5e94\u6301\u7eed\u8fdb\u884c\u60a3\u8005\u76d1\u6d4b\uff08\u81f3\u5c11\u81f3\u672b\u6b21\u7ed9\u836f\u540e<span>5<\/span>\u4e2a\u6708\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u5e94\u6682\u65f6\u505c\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\uff0c\u5e76\u5e94\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u3002\u5f53\u514d\u75ab\u76f8\u5173\u7684\u4e0d\u826f\u53cd\u5e94\u6539\u5584\u81f3\u2264<span>1<\/span>\u7ea7\u65f6\uff0c\u9700\u9010\u6b65\u51cf\u91cf\u81f3\u505c\u836f\u3002\u57fa\u4e8e\u6709\u9650\u7684\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff0c\u53d1\u751f\u7cd6\u76ae\u8d28\u6fc0\u7d20\u65e0\u6cd5\u63a7\u5236\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u65f6\u53ef\u4ee5\u8003\u8651\u4f7f\u7528\u5176\u4ed6\u5168\u8eab\u6027\u514d\u75ab\u6291\u5236\u5242\u3002\u5982\u679c\u4e0d\u826f\u53cd\u5e94\u4fdd\u6301\u5728\u2264<span>1<\/span>\u7ea7\uff0c\u4e14\u7cd6\u76ae\u8d28\u6fc0\u7d20\u5242\u91cf\u5df2\u964d\u81f3\u6bcf\u5929\u2264<span>10mg<\/span>\u6cfc\u5c3c\u677e\u6216\u7b49\u6548\u5242\u91cf\uff0c\u5219\u53ef\u5728\u6700\u540e\u4e00\u6b21\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ed9\u836f\u540e<span>12<\/span>\u5468\u5185\u91cd\u65b0\u5f00\u59cb\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u3002\u4e25\u91cd\u8005\u6216\u8bca\u65ad\u5b58\u7591\u8005\u53ef\u7531\u6d88\u5316\u79d1\u3001\u98ce\u6e7f\u79d1\u3001\u76ae\u80a4\u79d1\u3001\u547c\u5438\u79d1\u3001\u80bf\u7624\u79d1\u7b49\u7ec4\u6210\u7684\u514d\u75ab\u4e0d\u826f\u53cd\u5e94<span>MDT<\/span>\u8fdb\u884c\u4f1a\u8bca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u3001\u66f2\u59a5\u73e0\u5355\u6297<span> Trastuzumab<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u5242\uff1a<span>440mg<\/span>\uff08<span>20ml<\/span>\uff09<span>\/<\/span>\u74f6<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u8054\u5408\u5361\u57f9\u4ed6\u6ee8\u6216\u6c1f\u5c3f\u5627\u5576\u548c\u987a\u94c2\u9002\u7528\u4e8e\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u9488\u5bf9\u8f6c\u79fb\u6027\u75be\u75c5\u6cbb\u7597\u7684<span>HER2<\/span>\u9633\u6027\u7684\u8f6c\u79fb\u6027\u80c3\u817a\u764c\u6216\u80c3\u98df\u7ba1\u4ea4\u754c\u817a\u764c\u60a3\u8005\uff0c\u5bf9\u4e8e\u987a\u94c2\u548c\u6c1f\u5c3f\u5627\u5576\u7c7b\u8fdb\u5c55\uff0c\u800c\u672a\u4f7f\u7528\u8fc7\u66f2\u59a5\u73e0\u5355\u6297\u7684<span>HER2<\/span>\u9633\u6027\u7684\u8f6c\u79fb\u6027\u80c3\u764c\u60a3\u8005\uff0c\u53ef\u4ee5\u8003\u8651\u66f2\u59a5\u73e0\u5355\u6297\u8054\u5408\u5176\u4ed6\u6709\u6548\u7684\u5316\u7597\u836f\u7269\u6cbb\u7597\uff1b\u66f2\u59a5\u73e0\u5355\u6297\u53ea\u80fd\u7528\u4e8e<span>HER2<\/span>\u9633\u6027\u7684\u8f6c\u79fb\u6027\u80c3\u764c\u60a3\u8005\uff0c<span>HER2<\/span>\u9633\u6027\u7684\u5b9a\u4e49\u4e3a\u4f7f\u7528\u5df2\u9a8c\u8bc1\u7684\u68c0\u6d4b\u65b9\u6cd5\u5f97\u5230\u7684<span>IHC3+<\/span>\u6216<span>IHC2+\/FISH+<\/span>\u7ed3\u679c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u672c\u54c1\u6cbb\u7597\u524d\uff0c\u5e94\u8fdb\u884c<span>HER2<\/span>\u68c0\u6d4b\uff0c\u76f8\u5173\u68c0\u6d4b\u5e94\u4f7f\u7528\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66f2\u59a5\u73e0\u5355\u6297\u5f00\u59cb\u6cbb\u7597\u524d\u5e94\u8fdb\u884c\u5de6\u5ba4\u5c04\u8840\u5206\u6570\uff08<span>LVEF<\/span>\uff09\u7684\u68c0\u6d4b\uff0c\u6cbb\u7597\u671f\u95f4\u987b\u5bc6\u5207\u76d1\u6d4b<span>LVEF<\/span>\u3002<span>LVEF<\/span>\u8f83\u6cbb\u7597\u524d\u7edd\u5bf9\u6570\u503c\u4e0b\u964d\u2265<span>16%<\/span>\uff0c\u6216<span>LVEF<\/span>\u4f4e\u4e8e\u8be5\u68c0\u6d4b\u4e2d\u5fc3\u6b63\u5e38\u8303\u56f4\u5e76\u4e14<span>LVEF<\/span>\u8f83\u6cbb\u7597\u524d\u7edd\u5bf9\u6570\u503c\u4e0b\u964d\u2265<span>10%<\/span>\uff0c\u5e94\u505c\u6b62\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u81f3\u5c11<span>4<\/span>\u5468\uff0c\u5e76\u6bcf<span>4<\/span>\u5468\u68c0\u6d4b\u4e00\u6b21<span>LVEF<\/span>\u3002<span>4<\/span>\uff5e<span>8<\/span>\u5468\u5185<span>LVEF<\/span>\u56de\u5347\u81f3\u6b63\u5e38\u8303\u56f4\u6216<span>LVEF<\/span>\u8f83\u6cbb\u7597\u524d\u7edd\u5bf9\u6570\u503c\u4e0b\u964d\u2264<span>15%<\/span>\uff0c\u53ef\u6062\u590d\u4f7f\u7528\u66f2\u59a5\u73e0\u5355\u6297\u3002<span>LVEF<\/span>\u6301\u7eed\u4e0b\u964d\uff08\uff1e<span>8<\/span>\u5468\uff09\uff0c\u6216\u8005\u4e09\u6b21\u4ee5\u4e0a\u56e0\u5fc3\u810f\u6bd2\u6027\u800c\u505c\u6b62\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\uff0c\u5e94\u6c38\u4e45\u505c\u6b62\u4f7f\u7528\u66f2\u59a5\u73e0\u5355\u6297\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80c3\u764c\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u60a3\u8005\u51fa\u73b0\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\u3001\u5de6\u5fc3\u5ba4\u529f\u80fd\u660e\u663e\u4e0b\u964d\u3001\u4e25\u91cd\u7684\u8f93\u6ce8\u53cd\u5e94\u548c\u80ba\u90e8\u53cd\u5e94\u65f6\uff0c\u8981\u4e2d\u65ad\u6216\u505c\u6b62\u66f2\u59a5\u73e0\u5355\u6297\u7684\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5341\u4e00\u3001\u963f\u5e15\u66ff\u5c3c<span> Apatinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>0.25g<\/span>\u3001<span>0.375g<\/span>\u3001<span>0.425g<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7<span>2<\/span>\u79cd\u7cfb\u7edf\u5316\u7597\u540e\u8fdb\u5c55\u6216\u590d\u53d1\u7684\u665a\u671f\u80c3\u817a\u764c\u6216\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c\u60a3\u8005\uff0c\u4e14\u60a3\u8005\u63a5\u53d7\u963f\u5e15\u66ff\u5c3c\u6cbb\u7597\u65f6\u4e00\u822c\u72b6\u51b5\u826f\u597d\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u836f\u54c1\u8bf4\u660e\u4e66\u63a8\u8350\u5242\u91cf\u4e3a<span>850mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u3002\u5bf9\u4e8e\u4f53\u529b\u72b6\u6001\u8bc4\u5206<span>ECOG<\/span>\u2265<span>2<\/span>\u3001\u56db\u7ebf\u5316\u7597\u4ee5\u540e\u3001\u80c3\u90e8\u539f\u53d1\u764c\u7076\u6ca1\u6709\u5207\u9664\u3001\u9aa8\u9ad3\u529f\u80fd\u50a8\u5907\u5dee\u3001\u5e74\u8001\u4f53\u5f31\u6216\u7626\u5c0f\u7684\u5973\u6027\u60a3\u8005\uff0c\u4e3a\u4e86\u786e\u4fdd\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u63d0\u9ad8\u4f9d\u4ece\u6027\uff0c\u53ef\u4ee5\u9002\u5f53\u964d\u4f4e\u8d77\u59cb\u5242\u91cf\uff0c\u5148\u4ece<span>250mg<\/span>\u5f00\u59cb\u670d\u836f\uff0c\u670d\u7528<span>1<\/span>\uff5e<span>2<\/span>\u5468\u540e\u518d\u914c\u60c5\u589e\u52a0\u5242\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u51fa\u73b0<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\u65f6\uff0c\u5efa\u8bae\u6682\u505c\u7528\u836f\uff0c\u5e76\u5bf9\u75c7\u5904\u7406\uff0c\u5f85\u75c7\u72b6\u7f13\u89e3\u6062\u590d\u5230<span>1<\/span>\u7ea7\u4ee5\u5185\uff0c\u968f\u540e\u964d\u4f4e\u5242\u91cf\u670d\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u7279\u522b\u5173\u6ce8\u8840\u538b\u5347\u9ad8\u3001\u86cb\u767d\u5c3f\u3001\u624b\u8db3\u76ae\u80a4\u53cd\u5e94\u3001\u51fa\u8840\u3001\u5fc3\u810f\u6bd2\u6027\u3001\u809d\u810f\u6bd2\u6027\u7b49\u4e0d\u826f\u53cd\u5e94\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u614e\u4e0e\u5ef6\u957f<span>QTc<\/span>\u95f4\u671f\u7684\u836f\u7269\u540c\u65f6\u4f7f\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e8c\u3001<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297<span> Nivolumab<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:26.6pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a\u6ce8\u5c04\u6db2\uff1a<span>40mg<\/span>\uff08<span>4ml<\/span>\uff09<span>\/<\/span>\u74f6\u3001<span>100mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8054\u5408\u542b\u6c1f\u5c3f\u5627\u5576\u548c\u94c2\u7c7b\u836f\u7269\u5316\u7597\u9002\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80c3\u764c\u3001\u80c3\u98df\u7ba1\u8fde\u63a5\u90e8\u764c\u6216\u98df\u7ba1\u817a\u764c\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e24\u79cd\u6216\u4e24\u79cd\u4ee5\u4e0a\u5168\u8eab\u6027\u6cbb\u7597\u65b9\u6848\u7684\u665a\u671f\u6216\u590d\u53d1\u6027\u80c3\u6216\u80c3\u98df\u7ba1\u8fde\u63a5\u90e8\u817a\u764c\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5355\u836f\u6cbb\u7597\u63a8\u8350\u5242\u91cf\u4e3a<span>3mg\/kg<\/span>\u6216<span>240mg<\/span>\u56fa\u5b9a\u5242\u91cf\uff0c\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff0c\u9759\u8109\u8f93\u6ce8<span>30<\/span>\u5206\u949f\u3002\u8054\u5408\u542b\u6c1f\u5c3f\u5627\u5576\u548c\u94c2\u7c7b\u836f\u7269\u5316\u7597\uff0c\u63a8\u8350\u5242\u91cf\u4e3a<span>360 mg<\/span>\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c\u9759\u8109\u6ce8\u5c04\u6301\u7eed<span>30<\/span>\u5206\u949f\u6216\u672c\u54c1<span>240mg<\/span>\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff0c\u9759\u8109\u6ce8\u5c04\u6301\u7eed<span>30<\/span>\u5206\u949f\u3002\u6700\u957f\u6cbb\u7597\u6301\u7eed\u65f6\u95f4\u4e3a<span>24<\/span>\u4e2a\u6708\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53ea\u8981\u89c2\u5bdf\u5230\u4e34\u5e8a\u83b7\u76ca\uff0c\u5e94\u7ee7\u7eed\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\uff0c\u76f4\u81f3\u60a3\u8005\u4e0d\u80fd\u8010\u53d7\uff0c\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u8003\u8651\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u53ef\u80fd\uff0c\u4f46\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u6682\u505c\u7ed9\u836f\u6216\u505c\u836f\uff0c\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53d1\u751f<span>4<\/span>\u7ea7\u6216\u590d\u53d1\u6027<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u867d\u7136\u8fdb\u884c\u6cbb\u7597\u8c03\u6574\u4f46\u4ecd\u6301\u7eed\u5b58\u5728<span>2<\/span>\u7ea7\u6216<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u53d1\u751f<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u80ba\u708e\u3001\u809d\u708e\u3001\u5fc3\u808c\u708e\uff0c\u5e94\u6c38\u4e45\u6027\u505c\u7528\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u3002\u5982\u679c\u51fa\u73b0\u4efb\u4f55\u91cd\u5ea6\u3001\u590d\u53d1\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u4ee5\u53ca\u4efb\u4f55\u5371\u53ca\u751f\u547d\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5fc5\u987b\u6c38\u4e45\u505c\u6b62\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8001\u5e74\u60a3\u8005\uff08\u2265<span>65<\/span>\u5c81\uff09\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u6570\u636e\u6709\u9650\u3002\u8f7b\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u6ca1\u6709\u5bf9\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u8fdb\u884c\u672c\u54c1\u7684\u76f8\u5173\u7814\u7a76\uff0c\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\uff08\u603b\u80c6\u7ea2\u7d20\u3001<span>ALT<\/span>\u6216<span>AST<\/span>\uff1e<span>3<\/span>\u500d\u6b63\u5e38\u503c\u4e0a\u9650\uff09\u60a3\u8005\u614e\u7528\u672c\u54c1\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u4f7f\u7528\u672c\u54c1\u4e4b\u524d\u5e94\u907f\u514d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u836f\u7269\u53ef\u80fd\u4f1a\u5f71\u54cd\u672c\u54c1\u7684\u836f\u6548\u5b66\u6d3b\u6027\u53ca\u7597\u6548\u3002\u4f46\u5728\u672c\u54c1\u5f00\u59cb\u7ed9\u836f\u540e\uff0c\u53ef\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u514d\u75ab\u4ecb\u5bfc\u6027\u4e0d\u826f\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u53ef\u80fd\u5f15\u8d77\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5efa\u8bae\u6cbb\u7597\u524d\u8fdb\u884c\u5305\u62ec\u7532\u72b6\u817a\u529f\u80fd\u3001\u5fc3\u808c\u9176\u7b49\u7684\u57fa\u7ebf\u68c0\u6d4b\uff0c\u5728\u6cbb\u7597\u4e2d\u5b9a\u671f\u968f\u8bbf\u7528\u4e8e\u65e9\u671f\u53d1\u73b0\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56e0\u4e3a\u4e0d\u826f\u53cd\u5e94\u53ef\u80fd\u5728\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u671f\u95f4\u6216\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u505c\u6b62\u540e\u7684\u4efb\u4f55\u65f6\u95f4\u53d1\u751f\uff0c\u5e94\u6301\u7eed\u8fdb\u884c\u60a3\u8005\u76d1\u6d4b\uff08\u81f3\u5c11\u81f3\u672b\u6b21\u7ed9\u836f\u540e<span>5<\/span>\u4e2a\u6708\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u5e94\u6682\u505c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u5e76\u7ed9\u4e88\u7cd6\u76ae\u8d28\u6fc0\u7d20\u3002\u82e5\u4f7f\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u514d\u75ab\u6291\u5236\u7597\u6cd5\u6cbb\u7597\u4e0d\u826f\u53cd\u5e94\uff0c\u75c7\u72b6\u6539\u5584\u540e\uff0c\u9700\u9010\u6e10\u51cf\u91cf\u81f3\u505c\u836f\uff0c\u5feb\u901f\u51cf\u91cf\u53ef\u80fd\u5f15\u8d77\u4e0d\u826f\u53cd\u5e94\u6076\u5316\u6216\u590d\u53d1\u3002\u5982\u679c\u4f7f\u7528\u4e86\u7cd6\u76ae\u8d28\u6fc0\u7d20\u4f46\u4ecd\u6076\u5316\u6216\u65e0\u6539\u5584\uff0c\u5219\u5e94\u589e\u52a0\u975e\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6027\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u3002\u4e25\u91cd\u8005\u6216\u8bca\u65ad\u5b58\u7591\u8005\u53ef\u7531\u6d88\u5316\u79d1\u3001\u98ce\u6e7f\u79d1\u3001\u76ae\u80a4\u79d1\u3001\u547c\u5438\u79d1\u3001\u80bf\u7624\u79d1\u7b49\u7ec4\u6210\u7684\u514d\u75ab\u4e0d\u826f\u53cd\u5e94<span>MDT<\/span>\u8fdb\u884c\u4f1a\u8bca\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u60a3\u8005\u63a5\u53d7\u514d\u75ab\u6291\u5236\u5242\u91cf\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u671f\u95f4\uff0c\u4e0d\u53ef\u91cd\u65b0\u4f7f\u7528\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e09\u3001\u7ef4\u8fea\u897f\u59a5\u5355\u6297<span> DisitamabVedotin<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51bb\u5e72\u5236\u5242\uff1a<span>60mg\/<\/span>\u652f<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u81f3\u5c11\u63a5\u53d7\u8fc7<span>2<\/span>\u4e2a\u7cfb\u7edf\u5316\u7597\u7684<span>HER2<\/span>\u8fc7\u8868\u8fbe\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80c3\u764c\uff08\u5305\u62ec\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c\uff09\u7684\u60a3\u8005\u3002<span>HER2<\/span>\u8fc7\u8868\u8fbe\u5b9a\u4e49\u4e3a<span>HER2<\/span>\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u68c0\u67e5\u7ed3\u679c\u4e3a<span>2+<\/span>\u6216<span>3+<\/span>\uff0c\u65e0\u8bba<span>FiSH\/CiSH<\/span>\u6269\u589e\u4e0e\u5426\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u672c\u54c1\u6cbb\u7597\u524d\uff0c\u5e94\u8fdb\u884c<span>HER2<\/span>\u68c0\u6d4b\uff0c\u76f8\u5173\u68c0\u6d4b\u5e94\u4f7f\u7528\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a<span>2.5mg\/kg<\/span>\uff0c\u6bcf\u4e24\u5468\u4e00\u6b21\uff0c\u9759\u8109\u6ef4\u6ce8\uff0c\u5386\u65f6<span>30<\/span>\uff5e<span>90<\/span>\u5206\u949f\uff08\u901a\u5e38\u5efa\u8bae<span>60<\/span>\u5206\u949f\u5de6\u53f3\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8be5\u9002\u5e94\u8bc1\u662f\u57fa\u4e8e\u4e00\u9879<span>HER2<\/span>\u8fc7\u8868\u8fbe\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80c3\u764c\u60a3\u8005\uff08\u5305\u62ec\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c\uff09\u7684\u2161\u671f\u5355\u81c2\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u7ed9\u4e88\u7684\u9644\u6761\u4ef6\u6279\u51c6\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e38\u89c1\u7684\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u7c7b\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u8840\u6db2\u5b66\u5f02\u5e38\u3001\u8f6c\u6c28\u9176\u5347\u9ad8\u3002\u5e38\u89c1\u7684\u4e34\u5e8a\u75c7\u72b6\u3001\u4f53\u5f81\u7c7b\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u8131\u53d1\u3001\u4e4f\u529b\u3001\u611f\u89c9\u51cf\u9000\u7b49\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u60a3\u8005\u53d1\u751f\u4e0e\u836f\u7269\u76f8\u5173\u7684\u2265<span>3<\/span>\u7ea7\u8840\u6db2\u5f02\u5e38\uff0c\u5efa\u8bae\u6682\u505c\u6cbb\u7597\uff0c\u5bf9\u75c7\u6cbb\u7597\uff0c\u6bcf\u5468\u4e24\u6b21\u8fdb\u884c\u8840\u6db2\u5b66\u68c0\u67e5\uff0c\u76f4\u81f3\u6062\u590d\u81f3<span> CTCAE<\/span>\u2264<span>1<\/span>\u7ea7\u6216\u5f00\u59cb\u6cbb\u7597\u524d\u7684\u6c34\u5e73\uff0c\u82e5\u6062\u590d\u7528\u836f\u540e\u518d\u6b21\u53d1\u751f\u4e0d\u826f\u53cd\u5e94\uff0c\u5219\u5e94\u8c03\u6574\u7ed9\u836f\u5242\u91cf\u3002\u5982\u679c\u60a3\u8005\u5728\u6682\u505c\u7528\u836f<span>28<\/span>\u5929\u540e\u4ecd\u672a\u6062\u590d\u81f3<span> CTCAE<\/span>\u2264<span>1<\/span>\u7ea7\u6216\u5f00\u59cb\u6cbb\u7597\u524d\u7684\u6c34\u5e73\uff0c\u5219\u5efa\u8bae\u505c\u6b62\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u60a3\u8005\u53d1\u751f\u4e0e\u836f\u7269\u76f8\u5173\u7684\u2265<span>3<\/span>\u7ea7\u8f6c\u6c28\u9176\u5347\u9ad8\uff0c\u5efa\u8bae\u6682\u505c\u6cbb\u7597\uff0c\u5bf9\u75c7\u6cbb\u7597\uff0c\u6bcf\u5468\u4e24\u6b21\u8fdb\u884c\u8840\u751f\u5316\u68c0\u67e5\uff0c\u76f4\u81f3\u6062\u590d\u81f3<span> CTCAE<\/span>\u2264<span>1<\/span>\u7ea7\u6216\u5f00\u59cb\u6cbb\u7597\u524d\u7684\u6c34\u5e73\uff0c\u82e5\u6062\u590d\u7528\u836f\u540e\u518d\u6b21\u53d1\u751f\u4e0d\u826f\u53cd\u5e94\uff0c\u5219\u5e94\u8c03\u6574\u7ed9\u836f\u5242\u91cf\u3002\u5982\u679c\u60a3\u8005\u5728\u6682\u505c\u7528\u836f<span>28<\/span>\u5929\u540e\u4ecd\u672a\u6062\u590d\u81f3<span> CTCAE<\/span>\u2264<span>1<\/span>\u7ea7\u6216\u5f00\u59cb\u6cbb\u7597\u524d\u7684\u6c34\u5e73\uff0c\u5219\u5efa\u8bae\u505c\u6b62\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u60a3\u8005\u53d1\u751f\u4e86\u836f\u7269\u76f8\u5173\u7684\u611f\u89c9\u5f02\u5e38\uff08\u5982\u9ebb\u6728\u7b49\uff09\uff0c\u4e14\u5728\u6682\u505c\u7528\u836f<span>28<\/span>\u5929\u540e\u4ecd\u672a\u6062\u590d\u81f3\u53ef\u7ee7\u7eed\u7ed9\u836f\u7684\u6c34\u5e73\uff0c\u5efa\u8bae\u505c\u6b62\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002\u76ee\u524d\u5c1a\u672a\u8003\u5bdf\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u5bf9\u672c\u54c1\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u5f71\u54cd\u3002\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\uff0c\u76ee\u524d\u5c1a\u672a\u8bc4\u4f30\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u836f\u4ee3\u52a8\u529b\u5b66\uff0c\u5c1a\u65e0\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c1a\u672a\u786e\u7acb\u672c\u54c1\u5728<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u53ca\u9752\u5c11\u5e74\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u2265<span>65<\/span>\u5c81\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u4e0e\u6574\u4f53\u4eba\u7fa4\u76f8\u6bd4\u672a\u89c1\u660e\u663e\u5dee\u5f02\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u56db\u3001\u4f0a\u9a6c\u66ff\u5c3c<span> Imatinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08<span>1<\/span>\uff09\u7247\u5242\uff1a<span>100mg<\/span>\u3001<span>400mg<\/span>\uff1b\uff08<span>2<\/span>\uff09\u80f6\u56ca\uff1a<span>50mg<\/span>\u3001<span>100mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u6cbb\u7597\u4e0d\u80fd\u5207\u9664\u548c<span>\/<\/span>\u6216\u53d1\u751f\u8f6c\u79fb\u7684\u80c3\u80a0\u95f4\u8d28\u7624\u6210\u4eba\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e<span>C-Kit<\/span>\uff08<span>CD117<\/span>\uff09\u9633\u6027\u80c3\u80a0\u95f4\u8d28\u7624\u624b\u672f\u5207\u9664\u540e\u5177\u6709\u660e\u663e\u590d\u53d1\u98ce\u9669\u7684\u6210\u4eba\u60a3\u8005\u7684\u8f85\u52a9\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a<span>400mg\/d<\/span>\uff0c\u5747\u4e3a\u6bcf\u5929\u4e00\u6b21\u53e3\u670d\uff0c\u5b9c\u5728\u8fdb\u9910\u65f6\u670d\u836f\u3002\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u4f8b\u5982\uff1a\u4f53\u6db2\u6f74\u7559\u3001\u6076\u5fc3\u3001\u8179\u6cfb\u3001\u76ae\u75b9\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u3001\u8d2b\u8840\u3001\u75bc\u75db\u6027\u808c\u75c9\u631b\u4ee5\u53ca\u809d\u529f\u80fd\u635f\u4f24\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bc6\u5207\u5173\u6ce8\u809d\u529f\u80fd\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u540e\u82e5\u672a\u80fd\u83b7\u5f97\u6ee1\u610f\u7597\u6548\uff0c\u5982\u679c\u6ca1\u6709\u4e25\u91cd\u836f\u7269\u4e0d\u826f\u53cd\u5e94\uff0c\u5242\u91cf\u53ef\u589e\u52a0\u5230\u6bcf\u5929<span>0.6<\/span>\uff5e<span>0.8g<\/span>\uff1b\u82e5\u60a3\u8005\u4ece\u672c\u836f\u6301\u7eed\u83b7\u76ca\uff0c\u53ef\u6301\u7eed\u63a5\u53d7\u672c\u836f\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u6f5c\u5728\u53ef\u5207\u9664\u7684\u80c3\u80a0\u95f4\u8d28\u7624\u60a3\u8005\uff0c\u4f0a\u9a6c\u66ff\u5c3c\u65b0\u8f85\u52a9\u6cbb\u7597\u4e5f\u53ef\u4ee4\u60a3\u8005\u83b7\u76ca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u662f<span>CYP3A4<\/span>\u7684\u5e95\u7269\uff0c\u540c\u65f6\u7ed9\u4e88<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u540e\u4f0a\u9a6c\u66ff\u5c3c\u7684\u8840\u6d46\u6d53\u5ea6\u964d\u4f4e\uff0c\u4ece\u800c\u5bfc\u81f4\u7597\u6548\u51cf\u4f4e\uff0c\u5e94\u907f\u514d\u4f0a\u9a6c\u66ff\u5c3c\u4e0e<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u540c\u65f6\u670d\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u9a6c\u66ff\u5c3c\u5e94\u5728\u8fdb\u9910\u65f6\u670d\u7528\uff0c\u5e76\u996e\u4e00\u5927\u676f\u6c34\u3002\uff08<span>1<\/span>\uff09\u4f7f\u7528\u80f6\u56ca\u5242\u578b\u65f6\uff0c\u5bf9\u4e8e\u4e0d\u80fd\u541e\u54bd\u80f6\u56ca\u7684\u60a3\u8005\uff08\u5305\u62ec\u513f\u7ae5\uff09\uff0c\u53ef\u4ee5\u5c06\u80f6\u56ca\u5185\u836f\u7269\u5206\u6563\u4e8e\u6c34\u6216\u82f9\u679c\u6c41\u4e2d\u3002\u4f7f\u7528\u7247\u5242\u65f6\uff0c\u53ef\u4ee5\u5c06\u836f\u7247\u5206\u6563\u4e8e\u4e0d\u542b\u6c14\u4f53\u7684\u6c34\u6216\u82f9\u679c\u6c41\u4e2d\uff08<span>100mg<\/span>\u7247\u7ea6\u7528<span>50ml<\/span>\uff0c<span>400mg<\/span>\u7ea6\u7528<span>200ml<\/span>\uff09\u3002\u5e94\u6405\u62cc\u6df7\u60ac\u6db2\uff0c\u4e00\u65e6\u836f\u7247\u5d29\u89e3\u5b8c\u5168\u5e94\u7acb\u5373\u670d\u7528\u3002\uff08<span>2<\/span>\uff09\u5982\u679c\u63a5\u53d7\u4f0a\u9a6c\u66ff\u5c3c\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u51fa\u73b0\u4e25\u91cd\u975e\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94\uff08\u5982\u4e25\u91cd\u4f53\u6db2\u6f74\u7559\uff09\uff0c\u5e94\u505c\u836f\uff0c\u76f4\u5230\u4e0d\u826f\u53cd\u5e94\u6d88\u5931\uff0c\u7136\u540e\u518d\u6839\u636e\u8be5\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\u8c03\u6574\u5242\u91cf\u3002\uff08<span>3<\/span>\uff09\u5bf9\u4e8e<span>3<\/span>\u5c81\u4ee5\u4e0a\u513f\u7ae5\u4f7f\u7528\u4f0a\u9a6c\u66ff\u5c3c\u7684\u7814\u7a76\uff0c\u4e3b\u8981\u6765\u81ea\u56fd\u5916\u513f\u7ae5\u7814\u7a76\u6570\u636e\uff0c\u4e2d\u56fd\u513f\u7ae5\u4eba\u7fa4\u7528\u836f\u5b89\u5168\u6709\u6548\u6027\u6570\u636e\u6709\u9650\u3002\u5c1a\u65e0<span>3<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u7528\u836f\u7ecf\u9a8c\u3002\uff08<span>4<\/span>\uff09\u5df2\u6709\u62a5\u544a\u663e\u793a\u63a5\u53d7\u4f0a\u9a6c\u66ff\u5c3c\u6cbb\u7597\u7684\u513f\u7ae5\u548c\u9752\u6625\u524d\u671f\u9752\u5c11\u5e74\u51fa\u73b0\u53d1\u80b2\u8fdf\u7f13\u3002\u6682\u4e0d\u77e5\u4f0a\u9a6c\u66ff\u5c3c\u5ef6\u957f\u6cbb\u7597\u5bf9\u513f\u7ae5\u53d1\u80b2\u7684\u957f\u671f\u5f71\u54cd\u3002\u56e0\u6b64\uff0c\u5efa\u8bae\u5bf9\u4f7f\u7528\u4f0a\u9a6c\u66ff\u5c3c\u7684\u513f\u7ae5\u7684\u53d1\u80b2\u60c5\u51b5\u8fdb\u884c\u5bc6\u5207\u76d1\u6d4b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e94\u3001\u8212\u5c3c\u66ff\u5c3c<span> Sunitinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>12.5mg<\/span>\u3001<span>25mg<\/span>\u3001<span>37.5mg<\/span>\u3001<span>50mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u9a6c\u66ff\u5c3c\u6cbb\u7597\u5931\u8d25\u6216\u4e0d\u80fd\u8010\u53d7\u7684\u80c3\u80a0\u95f4\u8d28\u7624\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u53ef\u5207\u9664\u7684\u3001\u8f6c\u79fb\u6027\u9ad8\u5206\u5316\u8fdb\u5c55\u671f\u80f0\u817a\u795e\u7ecf\u5185\u5206\u6ccc\u7624\u6210\u5e74\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u80c3\u80a0\u95f4\u8d28\u7624\u7684\u6bcf\u5929\u63a8\u8350\u6700\u9ad8\u5242\u91cf\u4e3a<span>50mg<\/span>\uff0c\u670d\u836f<span>4<\/span>\u5468\u3001\u505c\u836f<span>2<\/span>\u5468\uff0c\u4e0e\u8fdb\u98df\u65e0\u76f8\u5173\u6027\uff1b\u82e5\u5fc5\u987b\u4e0e<span>CYP3A4<\/span>\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\uff0c\u5242\u91cf\u53ef\u51cf\u81f3<span>37.5mg<\/span>\uff1b\u82e5\u5fc5\u987b\u4e0e<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u8054\u5408\u4f7f\u7528\uff0c\u6700\u5927\u5242\u91cf\u4e0d\u8d85\u8fc7<span>87.5mg<\/span>\u3002\u5bf9\u4e8e\u80f0\u817a\u795e\u7ecf\u5185\u5206\u6ccc\u7624\uff0c\u63a8\u8350\u5242\u91cf\u4e3a<span>37.5mg<\/span>\uff0c\u53e3\u670d\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u8fde\u7eed\u670d\u836f\uff0c\u65e0\u505c\u836f\u671f\u3002\u4e0e\u98df\u7269\u540c\u670d\u6216\u4e0d\u540c\u670d\u5747\u53ef\u3002<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u4f8b\u5982\uff1a\u767d\u7ec6\u80de\u51cf\u5c11\u3001\u8179\u6cfb\u3001\u4e4f\u529b\u3001\u624b\u8db3\u7efc\u5408\u5f81\uff1b\u6f5c\u5728\u4e25\u91cd\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a\u809d\u6bd2\u6027\u3001\u5de6\u5fc3\u5ba4\u529f\u80fd\u969c\u788d\u3001<span>QTc<\/span>\u95f4\u671f\u5ef6\u957f\u3001\u51fa\u8840\u3001\u9ad8\u8840\u538b\u3001\u7532\u72b6\u817a\u529f\u80fd\u4e0d\u5168\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u82e5\u51fa\u73b0\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\u7684\u4e34\u5e8a\u8868\u73b0\uff0c\u5efa\u8bae\u505c\u836f\uff1b\u65e0\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\u4e34\u5e8a\u8bc1\u636e\u4f46\u5c04\u8840\u5206\u6570\uff1c<span>50%<\/span>\u4ee5\u53ca\u5c04\u8840\u5206\u6570\u4f4e\u4e8e\u57fa\u7ebf<span>20%<\/span>\u7684\u60a3\u8005\u4e5f\u5e94\u505c\u836f\u548c<span>\/<\/span>\u6216\u51cf\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53ef\u5ef6\u957f<span>QTc<\/span>\u95f4\u671f\uff0c\u4e14\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u3002\u5e94\u614e\u7528\u4e8e\u5df2\u77e5\u6709<span>QTc<\/span>\u95f4\u671f\u5ef6\u957f\u75c5\u53f2\u7684\u60a3\u8005\u3001\u670d\u7528\u6297\u5fc3\u5f8b\u5931\u5e38\u836f\u7269\u7684\u60a3\u8005\u6216\u6709\u76f8\u5e94\u57fa\u7840\u5fc3\u810f\u75be\u75c5\u3001\u5fc3\u52a8\u8fc7\u7f13\u548c\u7535\u89e3\u8d28\u7d0a\u4e71\u7684\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f7f\u7528\u671f\u95f4\u5982\u679c\u53d1\u751f\u4e25\u91cd\u9ad8\u8840\u538b\uff0c\u5e94\u6682\u505c\u4f7f\u7528\uff0c\u76f4\u81f3\u9ad8\u8840\u538b\u5f97\u5230\u63a7\u5236\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5177\u6709\u809d\u6bd2\u6027\uff0c\u53ef\u80fd\u5bfc\u81f4\u809d\u810f\u8870\u7aed\u6216\u6b7b\u4ea1\u3002\u5df2\u5728\u4e34\u5e8a\u7814\u7a76\u4e2d\u89c2\u5bdf\u5230\u809d\u810f\u8870\u7aed\u7684\u53d1\u751f\uff08\u53d1\u751f\u7387\uff1c<span>1%<\/span>\uff09\u3002\u5728\u6cbb\u7597\u5f00\u59cb\u524d\u3001\u6bcf\u4e2a\u6cbb\u7597\u5468\u671f\u3001\u4ee5\u53ca\u4e34\u5e8a\u9700\u8981\u65f6\u5e94\u76d1\u6d4b\u809d\u529f\u80fd\uff08<span>ALT<\/span>\uff0c<span>AST<\/span>\uff0c\u80c6\u7ea2\u7d20\uff09\u3002\u5f53\u51fa\u73b0<span>3<\/span>\u7ea7\u6216<span>4<\/span>\u7ea7\u836f\u7269\u76f8\u5173\u7684\u809d\u529f\u80fd\u4e0d\u826f\u53cd\u5e94\u5e94\u4e2d\u65ad\u7528\u836f\uff0c\u82e5\u65e0\u6cd5\u6062\u590d\u5e94\u7ec8\u6b62\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u516d\u3001\u963f\u4f10\u66ff\u5c3c <span>Avapritinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>100mg<\/span>\u3001<span>200mg<\/span>\u3001<span>300mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u643a\u5e26\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50\u53d7\u4f53<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:Symbol;\">a<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08<span>PDGFRA<\/span>\uff09\u5916\u663e\u5b50<span>18<\/span>\u7a81\u53d8\uff08\u5305\u62ec<span>PDGFRAD842V<\/span>\u7a81\u53d8\uff09\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u80c3\u80a0\u95f4\u8d28\u7624\u6210\u4eba\u60a3\u8005\u3002<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6bcf\u5929\u63a8\u8350\u53e3\u670d\u5242\u91cf\u4e3a<span>300mg<\/span>\uff0c\u81f3\u5c11\u5728\u9910\u524d<span>1<\/span>\u5c0f\u65f6\u548c\u9910\u540e<span>2<\/span>\u5c0f\u65f6\u7a7a\u8179\u7ed9\u836f\uff1b\u6301\u7eed\u6cbb\u7597\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u4e0e\u5f3a\u6548\u6216\u4e2d\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\u5408\u7528\uff1b\u5982\u679c\u65e0\u6cd5\u907f\u514d\u4e0e\u4e2d\u6548<span>CYP3A4<\/span>\u6291\u5236\u5242\u5408\u7528\uff0c\u8d77\u59cb\u5242\u91cf\u53ef\u964d\u4f4e\u81f3<span>100mg<\/span>\u6bcf\u5929\u4e00\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8be5\u9002\u5e94\u8bc1\u662f\u57fa\u4e8e\u4e00\u9879\u5305\u62ec<span>81<\/span>\u4f8b<span>PDGFRA<\/span>\u5916\u663e\u5b50<span>18<\/span>\u7a81\u53d8\u7684<span>NAVIGATOR<\/span>\u4e34\u5e8a\u7814\u7a76\u7684\u7ed3\u679c\u7ed9\u4e88\u7684\u9644\u6761\u4ef6\u6279\u51c6\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e74\u9f84\u2265<span>65<\/span>\u5c81\u60a3\u8005\u4e0d\u9700\u8c03\u6574\u5242\u91cf\uff1b<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u548c\u9752\u5c11\u5e74\u60a3\u8005\u614e\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u8f7b\u4e2d\u5ea6\u809d\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u4e0d\u5efa\u8bae\u8c03\u6574\u5242\u91cf\uff1b\u91cd\u5ea6\u809d\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u614e\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u6076\u5fc3\u3001\u75b2\u4e4f\u3001\u8d2b\u8840\u3001\u7736\u5468\u6c34\u80bf\u3001\u9762\u90e8\u6c34\u80bf\u3001\u9ad8\u80c6\u7ea2\u7d20\u8840\u75c7\u3001\u8179\u6cfb\u3001\u5455\u5410\u3001\u5916\u5468\u6c34\u80bf\u3001\u6d41\u6cea\u589e\u52a0\u3001\u98df\u6b32\u4e0b\u964d\u548c\u8bb0\u5fc6\u53d7\u635f\uff1b\u6700\u5e38\u89c1\u7684\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u4e3a\u8d2b\u8840\u548c\u80f8\u8154\u79ef\u6db2\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e03\u3001\u745e\u6d3e\u66ff\u5c3c<span> Ripretinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>50mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u63a5\u53d7\u8fc7<span>3<\/span>\u79cd\u6216\u4ee5\u4e0a\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08\u5305\u62ec\u4f0a\u9a6c\u66ff\u5c3c\uff09\u7684\u665a\u671f\u80c3\u80a0\u95f4\u8d28\u7624\u6210\u4eba\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6bcf\u5929\u63a8\u8350\u53e3\u670d\u5242\u91cf\u4e3a<span>150mg<\/span>\uff0c\u53ef\u4e0e\u98df\u7269\u540c\u670d\u6216\u7a7a\u8179\u7ed9\u836f\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u65e0\u6cd5\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u56e0\u4e0d\u826f\u53cd\u5e94\u9700\u964d\u4f4e\u5242\u91cf\uff0c\u63a8\u8350\u7684\u5242\u91cf\u4e3a<span>100mg<\/span>\u6bcf\u5929\u4e00\u6b21\uff1b\u5982\u60a3\u8005\u65e0\u6cd5\u8010\u53d7<span>100mg<\/span>\u6bcf\u5929\u4e00\u6b21\uff0c\u5219\u5e94\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8be5\u9002\u5e94\u8bc1\u662f\u57fa\u4e8e<span>4<\/span>\u7ebf\u80c3\u80a0\u95f4\u8d28\u7624<span>INVICTUS<\/span>\u7814\u7a76\u7ed3\u679c\u7ed9\u4e88\u7684\u9644\u6761\u4ef6\u6279\u51c6\uff1b\u8be5\u9002\u5e94\u8bc1\u7684\u5b8c\u5168\u6279\u51c6\u5c06\u53d6\u51b3\u4e8e\u6b63\u5728\u8fdb\u884c\u7684<span>ZL-2307-002<\/span>\u8bd5\u9a8c\u5728\u4e2d\u56fd\u60a3\u8005\u7684\u4e34\u5e8a\u83b7\u76ca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\uff1b\u5c1a\u672a\u5728\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u786e\u5b9a\u63a8\u8350\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5728\u513f\u7ae5\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5c1a\u4e0d\u660e\u786e\uff1b\u4e34\u5e8a\u7814\u7a76\u4e2d\u7eb3\u5165\u7684\u5e74\u9f84\u2265<span>65<\/span>\u5c81\u7684\u60a3\u8005\u6570\u5c1a\u4e0d\u8db3\u4ee5\u5145\u5206\u8bc1\u660e\u8001\u5e74\u60a3\u8005\u4e0e\u8f83\u5e74\u8f7b\u60a3\u8005\u4e4b\u95f4\u662f\u5426\u5b58\u5728\u836f\u7269\u5e94\u7b54\u5dee\u5f02\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u8131\u53d1\u3001\u75b2\u4e4f\u3001\u6076\u5fc3\u3001\u8179\u75db\u3001\u4fbf\u79d8\u3001\u808c\u75db\u3001\u8179\u6cfb\u3001\u98df\u6b32\u4e0b\u964d\u3001\u638c\u8dd6\u7ea2\u80bf\u7efc\u5408\u5f81\u548c\u5455\u5410\uff1b\u6700\u5e38\u89c1\u7684\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u4e3a\u8179\u75db\u3001\u8d2b\u8840\u3001\u6076\u5fc3\u548c\u5455\u5410\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u4e0e\u5f3a\u6548<span>CYP3A<\/span>\u8bf1\u5bfc\u5242\u3001\u6291\u5236\u5242\u5408\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u516b\u3001\u4f9d\u7ef4\u83ab\u53f8<span> Everolimus<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>2.5mg<\/span>\u3001<span>5mg<\/span>\u3001<span>10mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u53ef\u5207\u9664\u7684\u3001\u5c40\u90e8\u6669\u671f\u6216\u8f6c\u79fb\u6027\u7684\u3001\u5206\u5316\u826f\u597d\u7684\uff08\u4e2d\u5ea6\u6216\u9ad8\u5ea6\u5206\u5316\uff09\u8fdb\u5c55\u671f\u80f0\u817a\u795e\u7ecf\u5185\u5206\u6ccc\u7624\u6210\u4eba\u60a3\u8005\uff1b\u65e0\u6cd5\u624b\u672f\u5207\u9664\u7684\u3001\u5c40\u90e8\u6669\u671f\u6216\u8f6c\u79fb\u6027\u7684\u3001\u5206\u5316\u826f\u597d\u7684\u3001\u8fdb\u5c55\u671f\u975e\u529f\u80fd\u6027\u80c3\u80a0\u9053\u6216\u80ba\u6e90\u795e\u7ecf\u5185\u5206\u6ccc\u7624\u6210\u4eba\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u53e3\u8154\u708e\u3001\u76ae\u75b9\u3001\u75b2\u52b3\u3001\u8179\u6cfb\u3001\u611f\u67d3\u3001\u6076\u5fc3\u3001\u98df\u6b32\u4e0b\u964d\u3001\u8d2b\u8840\u3001\u5473\u89c9\u969c\u788d\u3001\u5468\u56f4\u6c34\u80bf\u3001\u9ad8\u8840\u7cd6\u548c\u5934\u75db\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u975e\u611f\u67d3\u6027\u80ba\u708e\u662f\u96f7\u5e15\u9709\u7d20\u884d\u751f\u7269\uff08\u5305\u62ec\u672c\u54c1\uff09\u7684\u7c7b\u6548\u5e94\u3002\u5bf9\u672c\u54c1\u6709\u6548\u6210\u5206\u3001\u5176\u4ed6\u96f7\u5e15\u9709\u7d20\u884d\u751f\u7269\u6216\u672c\u54c1\u4e2d\u4efb\u4f55\u8f85\u6599\u8fc7\u654f\u8005\u7981\u7528\u3002\u4f7f\u7528\u4f9d\u7ef4\u83ab\u53f8\u548c\u5176\u4ed6\u96f7\u5e15\u9709\u7d20\u884d\u751f\u7269\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u7684\u8fc7\u654f\u53cd\u5e94\u8868\u73b0\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\uff1a\u547c\u5438\u56f0\u96be\u3001\u6f6e\u7ea2\u3001\u80f8\u75db\u6216\u8840\u7ba1\u6027\u6c34\u80bf\uff08\u4f8b\u5982\uff1a\u4f34\u6216\u4e0d\u4f34\u547c\u5438\u529f\u80fd\u4e0d\u5168\u7684\u6c14\u9053\u6216\u820c\u80bf\u80c0\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u540c\u65f6\u4f7f\u7528\u8840\u7ba1\u7d27\u5f20\u7d20\u8f6c\u6362\u9176\u6291\u5236\u5242\u7684\u60a3\u8005\uff0c\u53ef\u80fd\u53d1\u751f\u8840\u7ba1\u6027\u6c34\u80bf\u7684\u98ce\u9669\u5347\u9ad8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u5e94\u907f\u514d\u63a5\u79cd\u6d3b\u75ab\u82d7\uff0c\u4f8b\u5982\u6d41\u611f\u3001\u9ebb\u75b9\u3001\u816e\u817a\u708e\u3001\u98ce\u75b9\u3001\u53e3\u670d\u810a\u9ad3\u7070\u8d28\u708e\u3001\u5361\u4ecb\u82d7\u3001\u9ec4\u70ed\u75c5\u3001\u6c34\u75d8\u548c<span>TY21a<\/span>\u4f24\u5bd2\u75ab\u82d7\u7b49\uff0c\u907f\u514d\u4e0e\u63a5\u79cd\u8fc7\u6d3b\u75ab\u82d7\u7684\u4eba\u5bc6\u5207\u63a5\u89e6\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u6240\u6709\u60a3\u8005\u90fd\u5e94\u8fdb\u884c\u5e38\u89c4\u7684\u4f9d\u7ef4\u83ab\u53f8\u5168\u8840\u8c37\u6d53\u5ea6\u76d1\u6d4b\u3002\u2265<span>65<\/span>\u5c81\u8001\u5e74\u60a3\u8005\u7528\u836f\u7684\u6b7b\u4ea1\u7387\u53ca\u53d1\u751f\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u800c\u7ec8\u6b62\u6cbb\u7597\u7684\u53d1\u751f\u7387\u660e\u663e\u589e\u9ad8\u3002\u56e0\u6b64\uff0c\u8001\u5e74\u60a3\u8005\u4f7f\u7528\u4f9d\u7ef4\u83ab\u53f8\uff0c\u5fc5\u987b\u76d1\u6d4b\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f\uff0c\u5e76\u53ca\u65f6\u8c03\u6574\u7528\u836f\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u907f\u514d\u5408\u5e76\u4f7f\u7528\u5f3a\u6548<span>CYP3A4<\/span>\u6216<span>P-<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\u3001<span>CYP3A4<\/span>\u5f3a\u6548\u8bf1\u5bfc\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e5d\u3001\u7d22\u51e1\u66ff\u5c3c <span>Surufatinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a<span>50mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e0\u6cd5\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u6669\u671f\u6216\u8f6c\u79fb\u6027\u3001\u8fdb\u5c55\u671f\u975e\u529f\u80fd\u6027\u3001\u5206\u5316\u826f\u597d\uff08<span>Gl<\/span>\u3001<span>G2<\/span>\uff09\u7684\u975e\u80f0\u817a\u6765\u6e90\u7684\u795e\u7ecf\u5185\u5206\u6ccc\u7624\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u4e8e<span>SANET-ep<\/span>\u7814\u7a76\uff0c\u63a8\u8350\u5242\u91cf\u4e3a<span>300mg<\/span><\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\/<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b21<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u8fde\u7eed\u670d\u836f\uff08\u6bcf<span>4<\/span>\u5468\u4e3a\u4e00\u4e2a\u6cbb\u7597\u5468\u671f\uff09\u3002\u53ef\u968f\u4f4e\u8102\u9910\uff08<span>500<\/span>\u5343\u5361\uff0c\u7ea6<span>20<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">%<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8102\u80aa\uff09<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u540c\u670d\u6216\u7a7a\u8179\u53e3\u670d\uff0c\u9700\u6574\u7c92\u541e\u670d\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u7528\u836f\u8fc7\u7a0b\u4e2d\u6839\u636e\u60a3\u8005\u4e2a\u4f53\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u8c03\u6574\u7528\u836f\uff0c\u5305\u62ec\u6682\u505c\u7528\u836f\u3001\u964d\u4f4e\u5242\u91cf\u6216\u6c38\u4e45\u505c\u7528\u672c\u54c1\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7528\u836f\u540e\uff0c\u5982<span>4<\/span>\u5468\u5185\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u81f3\u2264<span>1<\/span>\u7ea7\uff0c\u5efa\u8bae\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u8c03\u6574\u5242\u91cf\uff1a\u7b2c\u4e00\u6b21\u5242\u91cf\u8c03\u6574\u81f3\u6bcf\u5929<span>250mg<\/span>\uff1b\u7b2c\u4e8c\u6b21\u5242\u91cf\u8c03\u6574\u81f3\u6bcf\u5929<span>200mg<\/span>\uff1b\u82e5\u4ecd\u4e0d\u8010\u53d7\uff0c\u5219\u53ef\u8003\u8651<span>200mg<\/span>\u6bcf\u5929\u4e00\u6b21\u670d\u836f<span>3<\/span>\u5468\u505c\u836f<span>1<\/span>\u5468\u6216\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u5c1a\u65e0\u5bf9\u809d\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5f71\u54cd\u7684\u76f8\u5173\u6570\u636e\uff0c\u8f7b\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u8d77\u59cb\u5242\u91cf\uff0c\u4e2d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u987b\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u8f7b\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u987b\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\u5e76\u4e25\u5bc6\u76d1\u6d4b\u809d\u529f\u80fd\uff0c\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7981\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e25\u91cd\u6d3b\u52a8\u6027\u51fa\u8840\u3001\u6d3b\u52a8\u6027\u6d88\u5316\u9053\u6e83\u75a1\u3001\u672a\u6108\u5408\u7684\u80c3\u80a0\u7a7f\u5b54\u6216\u6d88\u5316\u9053\u7618\u60a3\u8005\u7981\u7528\u3002\u598a\u5a20\u3001\u54fa\u4e73\u671f\u5987\u5973\u7981\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u5c1a\u65e0\u672c\u54c1\u7528\u4e8e<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u6216\u9752\u5c11\u5e74\u60a3\u8005\u7684\u4e34\u5e8a\u6570\u636e\uff0c\u4e0d\u5efa\u8bae\u670d\u7528\u672c\u54c1\u3002\u5efa\u8bae\u8001\u5e74\u60a3\u8005\uff08<span>\u226565<\/span>\u5c81\uff09\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u65e0\u9700\u8c03\u6574\u8d77\u59cb\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u86cb\u767d\u5c3f\u3001\u9ad8\u8840\u538b\u3001\u8840\u80c6\u7ea2\u7d20\u5347\u9ad8\u3001\u8179\u6cfb\u3001\u8840\u767d\u86cb\u767d\u964d\u4f4e\u3001\u8840\u7518\u6cb9\u4e09\u916f\u5347\u9ad8\u3001<span>AST\/ALT<\/span>\u5347\u9ad8\u3001\u8840\u4fc3\u7532\u72b6\u817a\u6fc0\u7d20\u5347\u9ad8\u3001\u8179\u75db\u3001\u75b2\u4e4f<span>\/<\/span>\u4e4f\u529b\u3001\u8840\u5c3f\u9178\u5347\u9ad8\u3001\u51fa\u8840\u548c\u9aa8\u9abc\u808c\u8089\u75bc\u75db\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u907f\u514d\u6216\u614e\u91cd\u5408\u5e76\u4f7f\u7528<span>CYP3A4\/5<\/span>\u6291\u5236\u5242\u3001\u8bf1\u5bfc\u5242\u6216\u5e95\u7269\u3002<span style=\"color:red;\"><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u3001\u8d1d\u4f10\u73e0\u5355\u6297<span> Bevacizumab<\/span><\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>4ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408\u4ee5\u6c1f\u5c3f\u5627\u5576\u4e3a\u57fa\u7840\u7684\u5316\u7597\u9002\u7528\u4e8e\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u5168\u8eab\u7cfb\u7edf\u6027\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u4e00\u3001\u4e8c\u7ebf\u6cbb\u7597\uff0c\u53ef\u9009\u62e9\u8d1d\u4f10\u73e0\u5355\u6297<span>+<\/span>\u5316\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e00\u7ebf\u63a5\u53d7\u542b\u8d1d\u4f10\u73e0\u5355\u6297\u65b9\u6848\u6cbb\u7597\u75be\u75c5\u63a7\u5236\u540e\uff0c\u968f\u540e\u7ed9\u4e88\u8d1d\u4f10\u73e0\u5355\u6297<span>+<\/span>\u6c1f\u5c3f\u5627\u5576\u7c7b\u836f\u7269\u7ef4\u6301\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e00\u7ebf\u4f7f\u7528\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\u75be\u75c5\u8fdb\u5c55\u7684\u60a3\u8005\uff0c\u4e8c\u7ebf\u8f6c\u6362\u5316\u7597\u65b9\u6848\u540e\u53ef\u7ee7\u7eed\u8054\u7528\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\u76f4\u81f3\u75be\u75c5\u518d\u6b21\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u8d1d\u4f10\u73e0\u5355\u6297\u9759\u8109\u8f93\u6ce8\u7684\u63a8\u8350\u5242\u91cf\u4e3a\uff1a\u8054\u5408\u5316\u7597\u65b9\u6848\u65f6\uff0c<span>5mg\/kg<\/span>\u4f53\u91cd\uff0c\u6bcf\u4e24\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u6216<span>7.5mg\/kg<\/span>\u4f53\u91cd\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\u3002\u4e0d\u63a8\u8350\u964d\u4f4e\u8d1d\u4f10\u73e0\u5355\u6297\u7684\u4f7f\u7528\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u4e0e\u963f\u66ff\u5229\u73e0\u5355\u6297\u8054\u5408\u7528\u836f\u6cbb\u7597\u809d\u7ec6\u80de\u764c\u57fa\u4e8e<span>IMbrave150<\/span>\u7814\u7a76\uff1a\u63a8\u8350\u5242\u91cf\u4e3a<span>15mg\/kg<\/span>\u9759\u8109\u6ce8\u5c04\uff0c\u5728\u540c\u4e00\u5929\u9759\u8109\u6ce8\u5c04\u963f\u66ff\u5229\u73e0\u5355\u6297<span>1200mg<\/span>\u7ed9\u836f\u540e\u8fdb\u884c\uff0c\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297\u7a00\u91ca\u540e\u91c7\u7528\u9759\u8109\u8f93\u6ce8\u7684\u65b9\u5f0f\u7ed9\u836f\uff0c\u9996\u6b21\u9759\u8109\u8f93\u6ce8\u65f6\u95f4\u9700\u6301\u7eed<span>90<\/span>\u5206\u949f\u3002\u5982\u679c\u7b2c\u4e00\u6b21\u8f93\u6ce8\u8010\u53d7\u6027\u826f\u597d\uff0c\u5219\u7b2c\u4e8c\u6b21\u8f93\u6ce8\u7684\u65f6\u95f4\u53ef\u4ee5\u7f29\u77ed\u5230<span>60<\/span>\u5206\u949f\u3002\u5982\u679c\u60a3\u8005\u5bf9<span>60<\/span>\u5206\u949f\u7684\u8f93\u6ce8\u4e5f\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u90a3\u4e48\u968f\u540e\u8fdb\u884c\u7684\u6240\u6709\u8f93\u6ce8\u90fd\u53ef\u4ee5\u7528<span>30<\/span>\u5206\u949f\u7684\u65f6\u95f4\u5b8c\u6210\u3002\u8d1d\u4f10\u73e0\u5355\u6297\u4e0d\u80fd\u91c7\u7528\u9759\u8109\u5185\u63a8\u6ce8\u6216\u5feb\u901f\u6ce8\u5c04\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u8001\u5e74\u60a3\u8005\u4e2d\u5e94\u7528\u65f6\u4e0d\u9700\u8981\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51fa\u73b0\u4ee5\u4e0b\u60c5\u51b5\uff0c\u505c\u6b62\u4f7f\u7528\u8d1d\u4f10\u73e0\u5355\u6297\uff1a\u80c3\u80a0\u9053\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff08\u80c3\u80a0\u9053\u7a7f\u5b54\u3001\u80c3\u80a0\u9053\u7618\u5f62\u6210\u3001\u8179\u8154\u8113\u80bf\uff09\uff0c\u6d89\u53ca\u5230\u5185\u810f\u7618\u5f62\u6210\uff1b\u4e25\u91cd\u51fa\u8840\uff08\u4f8b\u5982\u9700\u8981\u5e72\u9884\u6cbb\u7597\uff09\uff1b\u4e25\u91cd\u52a8\u8109\u8840\u6813\u4e8b\u4ef6\uff1b\u9ad8\u8840\u538b\u5371\u8c61\u6216\u9ad8\u8840\u538b\u8111\u75c5\uff1b\u53ef\u9006\u6027\u540e\u90e8\u767d\u8d28\u8111\u75c5\u7efc\u5408\u5f81\uff1b\u80be\u75c5\u7efc\u5408\u5f81\uff1b\u5371\u53ca\u751f\u547d\uff08<span>4<\/span>\u7ea7\uff09\u7684\u9759\u8109\u8840\u6813\u6813\u585e\u4e8b\u4ef6\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u51fa\u73b0\u4ee5\u4e0b\u72b6\u51b5\uff0c\u9700\u6682\u505c\u4f7f\u7528\u8d1d\u4f10\u73e0\u5355\u6297\uff1a\u62e9\u671f\u624b\u672f\u524d<span>4<\/span>\u5468\uff1b\u836f\u7269\u63a7\u5236\u4e0d\u826f\u7684\u4e25\u91cd\u9ad8\u8840\u538b\uff1b\u4e2d\u5ea6\u5230\u91cd\u5ea6\u7684\u86cb\u767d\u5c3f\u9700\u8981\u8fdb\u4e00\u6b65\u8bc4\u4f30\uff1b\u4e25\u91cd\u8f93\u6db2\u53cd\u5e94\uff1b\u9700\u8981\u5e72\u9884\u6cbb\u7597\u7684\u4f24\u53e3\u88c2\u5f00\u4ee5\u53ca\u4f24\u53e3\u6108\u5408\u5e76\u53d1\u75c7\uff08\u6682\u505c\u7528\u836f\u81f3\u4f24\u53e3\u5b8c\u5168\u6108\u5408\uff09\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u80fd\u5c06\u8d1d\u4f10\u73e0\u5355\u6297\u8f93\u6ce8\u6db2\u4e0e\u53f3\u65cb\u7cd6\u6216\u8461\u8404\u7cd6\u6eb6\u6db2\u540c\u65f6\u6216\u6df7\u5408\u7ed9\u836f\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297\u914d\u5236\uff0c\u7528<span>0.9%<\/span>\u7684\u6c2f\u5316\u94a0\u6eb6\u6db2\u7a00\u91ca\u5230\u9700\u8981\u7684\u7ed9\u836f\u5bb9\u79ef\u3002\u8d1d\u4f10\u73e0\u5355\u6297\u6eb6\u6db2\u7684\u7ec8\u6d53\u5ea6\u5e94\u8be5\u4fdd\u6301\u5728<span>1.4<\/span>\uff5e<span>16.5mg\/ml<\/span>\u4e4b\u95f4\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">12.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u4f10\u73e0\u5355\u6297\u7981\u6b62\u51b7\u51bb\u50a8\u5b58\uff0c\u7981\u6b62\u6447\u52a8\u3002\u5e94\u907f\u5149\uff0c<span>2<\/span>\uff5e<span>8<\/span>\u2103\u5728\u539f\u5305\u88c5\u4e2d\u50a8\u5b58\u548c\u8fd0\u8f93\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">13.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728<span>2<\/span>\uff5e<span>30<\/span>\u2103\u6761\u4ef6\u4e0b\uff0c<span>0.9%<\/span>\u7684\u6c2f\u5316\u94a0\u6eb6\u6db2\u4e2d\uff0c\u8d1d\u4f10\u73e0\u5355\u6297\u5728\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u7684\u5316\u5b66\u548c\u7269\u7406\u7a33\u5b9a\u6027\u53ef\u4ee5\u4fdd\u6301<span>48<\/span>\u4e2a\u5c0f\u65f6\u3002\u4ea7\u54c1\u5728\u65e0\u83cc\u6761\u4ef6\u4e0b\u914d\u5236\u540e\u5728<span>2<\/span>\uff5e<span>8<\/span>\u2103\u6761\u4ef6\u4e0b\u7684\u50a8\u5b58\u65f6\u95f4\u4e0d\u5b9c\u8d85\u8fc7<span>24<\/span>\u5c0f\u65f6\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e00\u3001\u897f\u59a5\u6614\u5355\u6297<span> Cetuximab<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>20ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u6cbb\u7597<span>RAS<\/span>\u3001<span>BRAF<\/span>\u57fa\u56e0\u91ce\u751f\u578b\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff1a\u4e0e<span>FOLFOX<\/span>\u6216<span>FOLFIRI<\/span>\u65b9\u6848\u8054\u5408\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\uff1b\u4e0e\u4f0a\u7acb\u66ff\u5eb7\u8054\u5408\u7528\u4e8e\u7ecf\u542b\u4f0a\u7acb\u66ff\u5eb7\u6cbb\u7597\u5931\u8d25\u540e\u7684\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u4f7f\u7528\u7ecf\u8fc7\u9a8c\u8bc1\u7684\u65b9\u6cd5\u68c0\u6d4b<span>RAS<\/span>\u57fa\u56e0\u72b6\u6001\uff0c<span>RAS<\/span>\u57fa\u56e0\u91ce\u751f\u578b\u662f\u63a5\u53d7\u897f\u59a5\u6614\u5355\u6297\u6cbb\u7597\u7684\u5148\u51b3\u6761\u4ef6\uff0c\u672c\u54c1\u4e0d\u7528\u4e8e\u6cbb\u7597<span>RAS<\/span>\u57fa\u56e0\u7a81\u53d8\u578b\u6216<span>RAS<\/span>\u72b6\u6001\u4e0d\u660e\u7684\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f6c\u5316\u6027\u6cbb\u7597\uff1a\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u5408\u5e76\u809d\u8f6c\u79fb\u548c<span>\/<\/span>\u6216\u80ba\u8f6c\u79fb\uff0c\u6f5c\u5728\u53ef\u5207\u9664\uff0c\u53ef\u9009\u62e9\u897f\u59a5\u6614\u5355\u6297\u8054\u5408\u5316\u7597\uff08<span>RAS<\/span>\u91ce\u751f\u578b\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u59d1\u606f\u6cbb\u7597\uff1a\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff08<span>RAS<\/span>\u91ce\u751f\u578b\uff09\u4e00\u3001\u4e8c\u7ebf\u6cbb\u7597\uff0c\u5c24\u5176\u662f\u5de6\u534a\u80a0\u764c\u60a3\u8005\uff0c\u53ef\u9009\u62e9\u897f\u59a5\u6614\u5355\u6297<span>+<\/span>\u5316\u7597\u3002\u5bf9\u4e00\u3001\u4e8c\u7ebf\u6cbb\u7597\u4e2d\u6ca1\u6709\u4f7f\u7528\u897f\u59a5\u6614\u5355\u6297\u7684\u60a3\u8005\uff08<span>RAS<\/span>\u91ce\u751f\u578b\uff09\uff0c\u53ef\u9009\u62e9\u897f\u59a5\u6614\u5355\u6297\u8054\u5408\u4f0a\u7acb\u66ff\u5eb7\u5316\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u521d\u59cb\u4f7f\u7528\u897f\u59a5\u6614\u5355\u6297\u6cbb\u7597\u6709\u6548\uff08<span>CR\/PR\/SD<\/span>\uff09\uff0c\u8fdb\u5c55\u540e\u63a5\u53d7\u4e0d\u542b\u897f\u59a5\u6614\u5355\u6297\u7684\u4e8c\u7ebf\u6216\u540e\u7ebf\u6cbb\u7597\u5e76\u518d\u6b21\u53d1\u751f\u8fdb\u5c55\u65f6\uff0c\u5982<span>RAS<\/span>\u57fa\u56e0\u4ecd\u4e3a\u91ce\u751f\u578b\uff0c\u53ef\u8003\u8651\u897f\u59a5\u6614\u5355\u6297\u8054\u5408\u4f0a\u7acb\u66ff\u5eb7\u8fdb\u884c\u518d\u6311\u6218\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5e38\u53ef\u5f15\u8d77\u4e0d\u540c\u7a0b\u5ea6\u7684\u76ae\u80a4\u6bd2\u6027\u53cd\u5e94\uff0c\u4e3b\u8981\u8868\u73b0\u4e3a\u75e4\u75ae\u6837\u76ae\u75b9\uff0c\u6b64\u7c7b\u60a3\u8005\u7528\u836f\u671f\u95f4\u5e94\u6ce8\u610f\u907f\u5149\u3002\u8f7b\u4e2d\u5ea6\u76ae\u80a4\u6bd2\u6027\u53cd\u5e94\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u53d1\u751f\u91cd\u5ea6\u76ae\u80a4\u6bd2\u6027\u53cd\u5e94\u8005\uff0c\u5e94\u914c\u60c5\u51cf\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e25\u91cd\u7684\u8f93\u6db2\u53cd\u5e94\u53d1\u751f\u7387\u4e3a<span>3%<\/span>\uff0c\u81f4\u6b7b\u7387\u4f4e\u4e8e<span>0.1%<\/span>\u3002\u5176\u4e2d<span>90%<\/span>\u53d1\u751f\u4e8e\u7b2c\u4e00\u6b21\u4f7f\u7528\u65f6\uff0c\u4ee5\u7a81\u53d1\u6027\u6c14\u9053\u6897\u963b\u3001\u8368\u9ebb\u75b9\u548c\u4f4e\u8840\u538b\u4e3a\u7279\u5f81\u3002\u9996\u6b21\u6ef4\u6ce8\u672c\u54c1\u4e4b\u524d\uff0c\u60a3\u8005\u5fc5\u987b\u63a5\u53d7\u6297\u7ec4\u80fa\u836f\u7269\u548c\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7c7b\u836f\u7269\u7684\u6cbb\u7597\uff0c\u5efa\u8bae\u5728\u968f\u540e\u6bcf\u6b21\u4f7f\u7528\u672c\u54c1\u4e4b\u524d\u90fd\u5bf9\u60a3\u8005\u8fdb\u884c\u8fd9\u79cd\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4ec5\u5bf9\u809d\u80be\u529f\u80fd\u6b63\u5e38\u7684\u60a3\u8005\uff08\u8840\u6e05\u808c\u9150\u2264\u6b63\u5e38\u503c\u4e0a\u9650\u7684<span>1.5<\/span>\u500d\uff0c\u8f6c\u6c28\u9176\u2264\u6b63\u5e38\u503c\u4e0a\u9650\u7684<span>5<\/span>\u500d\uff0c\u80c6\u7ea2\u7d20\u2264\u6b63\u5e38\u503c\u4e0a\u9650\u7684<span>1.5<\/span>\u500d\uff09\u8fdb\u884c\u8fc7\u672c\u54c1\u7684\u76f8\u5173\u7814\u7a76\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5e94\u50a8\u5b58\u5728<span>2<\/span>\uff5e<span>8<\/span>\u2103\uff0c\u7981\u6b62\u51b7\u51bb\uff0c\u5f00\u542f\u540e\u5e94\u7acb\u5373\u4f7f\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e8c\u3001\u544b\u55b9\u66ff\u5c3c<span> Fruquintinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u786c\u80f6\u56ca\u5242\uff1a<span>1mg<\/span>\u3001<span>5mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\uff1a\u672c\u54c1\u5355\u836f\u9002\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u6c1f\u5c3f\u5627\u5576\u7c7b\u3001\u5965\u6c99\u5229\u94c2\u548c\u4f0a\u7acb\u66ff\u5eb7\u4e3a\u57fa\u7840\u7684\u5316\u7597\uff0c\u4ee5\u53ca\u65e2\u5f80\u63a5\u53d7\u8fc7\u6216\u4e0d\u9002\u5408\u63a5\u53d7<span>VEGF<\/span>\u6cbb\u7597\u3001<span>EGFR<\/span>\u6cbb\u7597\uff08<span>RAS<\/span>\u91ce\u751f\u578b\uff09\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08<span>mCRC<\/span>\uff09\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u65e0\u9700\u8fdb\u884c\u57fa\u56e0\u68c0\u6d4b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a<span>5mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e00\u6b21\uff1b\u8fde\u7eed\u670d\u836f<span>3<\/span>\u5468\uff0c\u968f\u540e\u505c\u836f<span>1<\/span>\u5468\uff08\u6bcf<span>4<\/span>\u5468\u4e3a\u4e00\u4e2a\u6cbb\u7597\u5468\u671f\uff09\u3002\u6301\u7eed\u6309\u6cbb\u7597\u5468\u671f\u670d\u836f\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u544b\u55b9\u66ff\u5c3c\u53ef\u4e0e\u98df\u7269\u540c\u670d\u6216\u7a7a\u8179\u53e3\u670d\uff0c\u9700\u6574\u7c92\u541e\u670d\u3002\u5efa\u8bae\u6bcf\u5929\u540c\u4e00\u65f6\u6bb5\u670d\u836f\uff0c\u5982\u679c\u670d\u836f\u540e\u60a3\u8005\u5455\u5410\uff0c\u65e0\u9700\u8865\u670d\uff1b\u6f0f\u670d\u5242\u91cf\uff0c\u4e0d\u5e94\u5728\u6b21\u65e5\u52a0\u670d\uff0c\u5e94\u6309\u5e38\u89c4\u670d\u7528\u4e0b\u4e00\u6b21\u5904\u65b9\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e2d\u56fd\u4eba\u7fa4\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u53d1\u751f\u7387\u2265<span>20%<\/span>\uff09\u4e3a\u9ad8\u8840\u538b\u3001\u86cb\u767d\u5c3f\u3001\u624b\u8db3\u76ae\u80a4\u53cd\u5e94\u3001\u53d1\u58f0\u56f0\u96be\u3001\u51fa\u8840\u3001\u8f6c\u6c28\u9176\u5347\u9ad8\u3001\u7532\u72b6\u817a\u529f\u80fd\u68c0\u67e5\u5f02\u5e38\u3001\u8179\u75db<span>\/<\/span>\u8179\u90e8\u4e0d\u9002\u3001\u53e3\u8154\u9ecf\u819c\u708e\u3001\u75b2\u4e4f<span>\/<\/span>\u4e4f\u529b\u3001\u8179\u6cfb\u3001\u611f\u67d3\u3001\u8840\u80c6\u7ea2\u7d20\u5347\u9ad8\u4ee5\u53ca\u98df\u6b32\u4e0b\u964d\u3002\u76ee\u524d\u5c1a\u672a\u6709\u836f\u7269\u6027\u809d\u529f\u80fd\u635f\u4f24\u7684\u62a5\u544a\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e25\u91cd\u6d3b\u52a8\u6027\u51fa\u8840\u3001\u6d3b\u52a8\u6027\u6d88\u5316\u6027\u6e83\u75a1\u3001\u672a\u6108\u5408\u7684\u80c3\u80a0\u7a7f\u5b54\u3001\u6d88\u5316\u9053\u7618\u60a3\u8005\u7981\u7528\u3002\u91cd\u5ea6\u809d\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7981\u7528\u3002\u598a\u5a20\u3001\u54fa\u4e73\u671f\u5987\u5973\u7981\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5bf9\u672c\u54c1\u4efb\u4f55\u6210\u5206\u8fc7\u654f\u8005\u7981\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u5c1a\u65e0\u672c\u54c1\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u7684\u4e34\u5e8a\u8d44\u6599\u3002<span><\/span><\/span>\n<\/p>\n<p><b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><br \/>\n<\/span><\/b> <\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8840\u6db2\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e00\u3001\u4f0a\u9a6c\u66ff\u5c3c<span> Imatinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08<span>1<\/span>\uff09\u7247\u5242\uff1a<span>100mg<\/span>\u3001<span>400mg<\/span>\uff1b\uff08<span>2<\/span>\uff09\u80f6\u56ca\uff1a<span>50mg<\/span>\u3001<span>100mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u6cbb\u7597\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u7684\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08<span>Ph+CML<\/span>\uff09\u7684\u6162\u6027\u671f\u3001\u52a0\u901f\u671f\u6216\u6025\u53d8\u671f\uff1b\u8054\u5408\u5316\u7597\u6cbb\u7597\u65b0\u8bca\u65ad\u7684\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u7684\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08<span>Ph+ALL<\/span>\uff09\u7684\u513f\u7ae5\u60a3\u8005\uff1b\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u7684\u6216\u96be\u6cbb\u7684\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u7684\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08<span>Ph+ALL<\/span>\uff09\u7684\u6210\u4eba\u60a3\u8005\uff1b\u7528\u4e8e\u6cbb\u7597\u55dc\u9178\u7c92\u7ec6\u80de\u589e\u591a\u7efc\u5408\u5f81\uff08<span>HES<\/span>\uff09\u548c<span>\/<\/span>\u6216\u6162\u6027\u55dc\u9178\u7c92\u7ec6\u80de\u767d\u8840\u75c5\uff08<span>CEL<\/span>\uff09\u4f34\u6709<span>FIP1L1-PDGFR<\/span>\u03b1\u878d\u5408\u57fa\u56e0\u7684\u6210\u5e74\u60a3\u8005\uff1b\u7528\u4e8e\u6cbb\u7597\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81<span>\/<\/span>\u9aa8\u9ad3\u589e\u6b96\u6027\u75be\u75c5\uff08<span>MDS\/MPD<\/span>\uff09\u4f34\u6709\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08<span>PDGFR<\/span>\uff09\u57fa\u56e0\u91cd\u6392\u7684\u6210\u5e74\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u8bca\u65ad\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u6216<span>BCR-ABL<\/span>\u9633\u6027\u7684\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u6216\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff0c\u6216\u4f34\u6709<span>PDGFR<\/span>\u57fa\u56e0\u91cd\u6392\u7684\u9ad3\u7cfb\u589e\u6b96\u6027\u80bf\u7624\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u5f53\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\u8bc4\u4f30\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u8840\u6db2\u5b66\u3001\u7ec6\u80de\u9057\u4f20\u5b66\u548c\u5206\u5b50\u751f\u7269\u5b66\u53cd\u5e94\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e0d\u540c\u75be\u75c5\u79cd\u7c7b\u548c\u5206\u671f\uff0c\u9009\u62e9\u521d\u59cb\u6cbb\u7597\u5242\u91cf\uff0c\u6cbb\u7597\u4e2d\u6839\u636e\u7597\u6548\u548c\u4e0d\u826f\u53cd\u5e94\u8c03\u6574\u5242\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e38\u89c1\u4e0d\u826f\u4e8b\u4ef6\uff08\uff1e<span>10%<\/span>\uff09\u4e3a\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u3001\u8d2b\u8840\u3001\u5934\u75db\u3001\u6d88\u5316\u4e0d\u826f\u3001\u6c34\u80bf\u3001\u4f53\u91cd\u589e\u52a0\u3001\u6076\u5fc3\u3001\u5455\u5410\u3001\u808c\u8089\u75c9\u631b\u3001\u808c\u8089\u9aa8\u9abc\u75db\u3001\u8179\u6cfb\u3001\u76ae\u75b9\u3001\u75b2\u52b3\u548c\u8179\u75db\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u671f\u95f4\u56e0\u6bd2\u6027\u4e0d\u53ef\u8010\u53d7\u6216\u8010\u836f\u65f6\uff0c\u53ef\u9009\u62e9\u4e8c\u4ee3\u836f\u7269\u66ff\u6362\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u9a6c\u66ff\u5c3c\u7528\u4e8e\u6210\u4eba\u521d\u6cbb\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u7684\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08\u5168\u7403\u5176\u4ed6\u56fd\u5bb6\u5df2\u6279\u51c6\u7684\u9002\u5e94\u8bc1\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u662f<span>CYP3A4<\/span>\u7684\u5e95\u7269\uff0c\u540c\u65f6\u7ed9\u4e88<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u540e\u4f0a\u9a6c\u66ff\u5c3c\u7684\u8840\u6d46\u6d53\u5ea6\u964d\u4f4e\uff0c\u4ece\u800c\u5bfc\u81f4\u7597\u6548\u51cf\u4f4e\uff0c\u5e94\u907f\u514d\u4f0a\u9a6c\u66ff\u5c3c\u4e0e<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u540c\u65f6\u670d\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u9a6c\u66ff\u5c3c\u5e94\u5728\u8fdb\u9910\u65f6\u670d\u7528\uff0c\u5e76\u996e\u4e00\u5927\u676f\u6c34\u3002\uff08<span>1<\/span>\uff09\u4f7f\u7528\u80f6\u56ca\u5242\u578b\u65f6\uff0c\u5bf9\u4e8e\u4e0d\u80fd\u541e\u54bd\u80f6\u56ca\u7684\u60a3\u8005\uff08\u5305\u62ec\u513f\u7ae5\uff09\uff0c\u53ef\u4ee5\u5c06\u80f6\u56ca\u5185\u836f\u7269\u5206\u6563\u4e8e\u6c34\u6216\u82f9\u679c\u6c41\u4e2d\u3002\u4f7f\u7528\u7247\u5242\u65f6\uff0c\u53ef\u4ee5\u5c06\u836f\u7247\u5206\u6563\u4e8e\u4e0d\u542b\u6c14\u4f53\u7684\u6c34\u6216\u82f9\u679c\u6c41\u4e2d\uff08<span>100mg<\/span>\u7247\u7ea6\u7528<span>50ml<\/span>\uff0c<span>400mg<\/span>\u7ea6\u7528<span>200ml<\/span>\uff09\u3002\u5e94\u6405\u62cc\u6df7\u60ac\u6db2\uff0c\u4e00\u65e6\u836f\u7247\u5d29\u89e3\u5b8c\u5168\u5e94\u7acb\u5373\u670d\u7528\u3002\uff08<span>2<\/span>\uff09\u5982\u679c\u63a5\u53d7\u4f0a\u9a6c\u66ff\u5c3c\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u51fa\u73b0\u4e25\u91cd\u975e\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94\uff08\u5982\u4e25\u91cd\u4f53\u6db2\u6f74\u7559\uff09\uff0c\u5e94\u505c\u836f\uff0c\u76f4\u5230\u4e0d\u826f\u53cd\u5e94\u6d88\u5931\uff0c\u7136\u540e\u518d\u6839\u636e\u8be5\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\u8c03\u6574\u5242\u91cf\u3002\uff08<span>3<\/span>\uff09\u5bf9\u4e8e<span>3<\/span>\u5c81\u4ee5\u4e0a\u513f\u7ae5\u4f7f\u7528\u4f0a\u9a6c\u66ff\u5c3c\u7684\u7814\u7a76\uff0c\u4e3b\u8981\u6765\u81ea\u56fd\u5916\u513f\u7ae5\u7814\u7a76\u6570\u636e\uff0c\u4e2d\u56fd\u513f\u7ae5\u4eba\u7fa4\u7528\u836f\u5b89\u5168\u6709\u6548\u6027\u6570\u636e\u6709\u9650\u3002\u5c1a\u65e0<span>3<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u7528\u836f\u7ecf\u9a8c\u3002\uff08<span>4<\/span>\uff09\u5df2\u6709\u62a5\u544a\u663e\u793a\u63a5\u53d7\u4f0a\u9a6c\u66ff\u5c3c\u6cbb\u7597\u7684\u513f\u7ae5\u548c\u9752\u6625\u524d\u671f\u9752\u5c11\u5e74\u51fa\u73b0\u53d1\u80b2\u8fdf\u7f13\u3002\u6682\u4e0d\u77e5\u4f0a\u9a6c\u66ff\u5c3c\u5ef6\u957f\u6cbb\u7597\u5bf9\u513f\u7ae5\u53d1\u80b2\u7684\u957f\u671f\u5f71\u54cd\u3002\u56e0\u6b64\uff0c\u5efa\u8bae\u5bf9\u4f7f\u7528\u4f0a\u9a6c\u66ff\u5c3c\u7684\u513f\u7ae5\u7684\u53d1\u80b2\u60c5\u51b5\u8fdb\u884c\u5bc6\u5207\u76d1\u6d4b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u8fbe\u6c99\u66ff\u5c3c<span> Dasatinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>20mg<\/span>\u3001<span>50mg<\/span>\u3001<span>70mg<\/span>\u3001<span>100mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4f0a\u9a6c\u66ff\u5c3c\u8010\u836f\uff0c\u6216\u4e0d\u8010\u53d7\u7684\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u6162\u6027\u671f\u3001\u52a0\u901f\u671f\u548c\u6025\u53d8\u671f\uff08\u6025\u7c92\u53d8\u548c\u6025\u6dcb\u53d8\uff09\u6210\u5e74\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u8bca\u65ad\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u6216<span>BCR-ABL<\/span>\u9633\u6027\u7684\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u6216\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u8be5\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\uff08\u5305\u62ec<span>BCR-ABL<\/span>\u7a81\u53d8\uff09\u8bc4\u4f30\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u8840\u6db2\u5b66\u3001\u7ec6\u80de\u9057\u4f20\u5b66\u548c\u5206\u5b50\u5b66\u53cd\u5e94\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e0d\u540c\u75be\u75c5\u79cd\u7c7b\u548c\u5206\u671f\uff0c\u9009\u62e9\u521d\u59cb\u6cbb\u7597\u5242\u91cf\uff0c\u6cbb\u7597\u4e2d\u6839\u636e\u7597\u6548\u548c\u4e0d\u826f\u53cd\u5e94\u8c03\u6574\u5242\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e38\u89c1\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u3001\u8d2b\u8840\u3001\u80f8\u8154\u79ef\u6db2\u3001\u5934\u75db\u3001\u8179\u6cfb\u3001\u75b2\u52b3\u7b49\uff0c\u5c11\u6570\u6709\u80ba\u52a8\u8109\u9ad8\u538b\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u662f<span>CYP3A4<\/span>\u7684\u5e95\u7269\uff0c\u4e0d\u63a8\u8350\u8054\u5408\u5f3a\u6548\u7684<span>CYP3A4<\/span>\u6291\u5236\u5242\u3002\u5982\u679c\u65e0\u6cd5\u907f\u514d\u5408\u5e76\u7528\u836f\uff0c\u5219\u5e94\u5bf9\u6bd2\u6027\u53cd\u5e94\u8fdb\u884c\u5bc6\u5207\u76d1\u6d4b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fbe\u6c99\u66ff\u5c3c\u7528\u4e8e\u6210\u4eba\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u7684\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08<span>FDA<\/span>\u5df2\u6279\u51c6\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e09\u3001\u5c3c\u6d1b\u66ff\u5c3c<span> Nilotinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>150mg<\/span>\u3001<span>200mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65b0\u8bca\u65ad\u7684\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u7684\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u6162\u6027\u671f\u6210\u4eba\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u65e2\u5f80\u6cbb\u7597\uff08\u5305\u62ec\u4f0a\u9a6c\u66ff\u5c3c\uff09\u8010\u836f\u6216\u4e0d\u8010\u53d7\u7684\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u7684<span>Ph+CML<\/span>\u6162\u6027\u671f\u6216\u52a0\u901f\u671f\u6210\u4eba\u60a3\u8005\u3002<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c3c\u6d1b\u66ff\u5c3c\u4e0d\u53ef\u7528\u4e8e\u4f4e\u8840\u94be\u3001\u4f4e\u8840\u9541\u6216\u957f<span>QT<\/span>\u7efc\u5408\u5f81\u7684\u60a3\u8005\u3002\u5728\u4f7f\u7528\u5c3c\u6d1b\u66ff\u5c3c\u4ee5\u524d\u5fc5\u987b\u7ea0\u6b63\u4f4e\u94be\u548c\u4f4e\u9541\uff0c\u5e76\u5b9a\u671f\u8fdb\u884c\u76d1\u6d4b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e38\u89c1\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u3001\u8d2b\u8840\u3001\u98df\u6b32\u51cf\u9000\u3001\u76ae\u75b9\u3001\u808c\u8089\u5173\u8282\u75db\u7b49\u3002<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u8054\u5408\u53ef\u5ef6\u957f<span>QTc<\/span>\u95f4\u671f\u7684\u836f\u7269\u548c<span>CYP3A4<\/span>\u7684\u5f3a\u6548\u6291\u5236\u5242\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u809d\u529f\u80fd\u635f\u4f24\u7684\u60a3\u8005\u5efa\u8bae\u51cf\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u5f00\u59cb\u7ed9\u836f\u524d\u3001\u7ed9\u836f\u8fc7\u7a0b\u4e2d\u3001\u7ed9\u836f\u540e\u5747\u5e94\u5b9a\u671f\u8fdb\u884c\u5fc3\u7535\u56fe\u68c0\u67e5\u4ee5\u76d1\u6d4b<span>QTc<\/span>\uff0c\u5e76\u4e14\u5728\u4efb\u4f55\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u65f6\u4e5f\u5e94\u5982\u6b64\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56db\u3001\u5409\u745e\u66ff\u5c3c<span> Gilteritinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>40mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u7528\u4e8e\u6cbb\u7597\u91c7\u7528\u7ecf\u5145\u5206\u9a8c\u8bc1\u7684\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u5230\u643a\u5e26<span>FMS<\/span>\u6837\u916a\u6c28\u9178\u6fc0\u9176<span>3<\/span>\uff08<span>FLT3<\/span>\uff09\u7a81\u53d8\u7684\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08<span>AML<\/span>\uff09\u6210\u4eba\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u4f7f\u7528\u5bcc\u9a6c\u9178\u5409\u745e\u66ff\u5c3c\u7247\u4e4b\u524d\uff0c\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027<span>AML<\/span>\u60a3\u8005\u5fc5\u987b\u786e\u5b9a\u5176\u5916\u5468\u8840\u6216\u9aa8\u9ad3\u5177\u6709<span>FLT3<\/span>\u7a81\u53d8<span>[<\/span>\u5185\u90e8\u4e32\u8054\u91cd\u590d\uff08<span>ITD<\/span>\uff09\u6216\u916a\u6c28\u9178\u6fc0\u9176\u57df\uff08<span>TKD<\/span>\uff09<span>]<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u5f53\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\u8bc4\u4f30\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u8840\u6db2\u5b66\u3001\u7ec6\u80de\u9057\u4f20\u5b66\u548c\u5206\u5b50\u751f\u7269\u5b66\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bcc\u9a6c\u9178\u5409\u745e\u66ff\u5c3c\u7247\u7684\u63a8\u8350\u8d77\u59cb\u5242\u91cf\u4e3a<span>120mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u6bcf<span>28<\/span>\u5929\u4e3a\u4e00\u4e2a\u6cbb\u7597\u5468\u671f\u3002\u53e3\u670d\u7ed9\u836f\uff0c\u6574\u7247\u7528\u6c34\u9001\u670d\uff0c\u4e0d\u5f97\u63b0\u5f00\u6216\u78be\u788e\uff0c\u6bcf\u5929\u5927\u7ea6\u540c\u4e00\u65f6\u95f4\u670d\u7528\u3002\u5982\u6f0f\u670d\u6216\u672a\u5728\u539f\u8ba1\u5212\u65f6\u95f4\u670d\u836f\uff0c\u53ef\u4ee5\u5728\u5f53\u65e5\u5185\u5c3d\u5feb\u670d\u7528\uff0c\u4f46\u5e94\u5728\u4e0b\u4e00\u6b21\u6309\u8ba1\u5212\u670d\u836f\u7684<span> 12 <\/span>\u5c0f\u65f6\u524d\u8865\u670d\uff0c\u7b2c\u4e8c\u5929\u7ee7\u7eed\u6b63\u5e38\u8ba1\u5212\u65f6\u95f4\u670d\u836f\u3002\u6cbb\u7597\u4e2d\u6839\u636e\u7597\u6548\u548c\u4e0d\u826f\u53cd\u5e94\u8c03\u6574\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u6cbb\u7597\u5e94\u6301\u7eed\u8fdb\u884c\uff0c\u76f4\u81f3\u60a3\u8005\u4e0d\u518d\u6709\u4e34\u5e8a\u83b7\u76ca\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u7531\u4e8e\u4e34\u5e8a\u7f13\u89e3\u53ef\u80fd\u4f1a\u5ef6\u8fdf\uff0c\u56e0\u6b64\uff0c\u5e94\u8003\u8651\u4ee5\u5904\u65b9\u5242\u91cf\u6301\u7eed\u6cbb\u7597\u957f\u8fbe\u81f3<span>6<\/span>\u4e2a\u6cbb\u7597\u5468\u671f\uff0c\u786e\u4fdd\u6709\u5145\u5206\u65f6\u95f4\u8fbe\u5230\u4e34\u5e8a\u7f13\u89e3\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u6cbb\u7597<span>4<\/span>\u5468\u540e\u672a\u5b9e\u73b0\u4ee5\u4e0b\u51e0\u79cd\u60c5\u5f62\u4e4b\u4e00\uff0c\u5219\u5e94\u5728\u60a3\u8005\u8010\u53d7\u6216\u4e34\u5e8a\u6709\u4fdd\u8bc1\u7684\u60c5\u51b5\u4e0b\uff0c\u5c06\u5242\u91cf\u589e\u81f3<span>200mg<\/span>\u6bcf\u5929\u4e00\u6b21\uff1a\uff08<span>1<\/span>\uff09\u5b8c\u5168\u7f13\u89e3\uff08<span>CR<\/span>\uff09\u3002\uff08<span>2<\/span>\uff09\u9664\u8840\u5c0f\u677f\u6062\u590d\u4e0d\u5b8c\u5168\uff08\u8840\u5c0f\u677f\uff1c<span>100\u00d710<sup>9<\/sup>\/L<\/span>\uff09\uff0c\u5176\u4ed6\u6807\u51c6\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\uff08<span>CRp<\/span>\uff09\u3002\uff08<span>3<\/span>\uff09\u9664\u4ecd\u6709\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff08\u4e2d\u6027\u7c92\u7ec6\u80de\uff1c<span>1\u00d710<sup>9<\/sup>\/L<\/span>\uff09\uff0c\u4f34\u6216\u4e0d\u4f34\u8840\u5c0f\u677f\u5b8c\u5168\u6062\u590d\uff0c\u5176\u4ed6\u6807\u51c6\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\uff08<span>CRi<\/span>\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u5728\u6cbb\u7597\u5f00\u59cb\u524d\uff0c\u7b2c<span>1<\/span>\u4e2a\u6cbb\u7597\u5468\u671f\u7684\u6bcf\u5468\uff0c\u7b2c<span>2<\/span>\u4e2a\u6cbb\u7597\u5468\u671f\u7684\u7b2c<span>2<\/span>\u5468\uff0c\u548c\u4e4b\u540e\u7684\u6bcf\u4e2a\u6cbb\u7597\u5468\u671f\u8fdb\u884c\u8840\u7ec6\u80de\u8ba1\u6570\u548c\u8840\u6db2\u751f\u5316\u8bc4\u4f30\uff08\u5305\u62ec\u808c\u9178\u78f7\u9178\u6fc0\u9176\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u5728\u7ed9\u4e88\u672c\u54c1\u6cbb\u7597\u5f00\u59cb\u524d\uff0c\u7b2c<span>1<\/span>\u4e2a\u5468\u671f\u7684\u7b2c<span>8<\/span>\u5929\u548c\u7b2c<span>15<\/span>\u5929\uff0c\u4ee5\u53ca\u540e\u7eed<span>2<\/span>\u4e2a\u5468\u671f\u6cbb\u7597\u5f00\u59cb\u524d\u8fdb\u884c\u5fc3\u7535\u56fe\u68c0\u67e5\u3002<span>QTc<\/span>\u95f4\u671f\u5ef6\u957f\uff08\uff1e<span>500ms<\/span>\uff09\u7684\u60a3\u8005\u5e94\u4e2d\u65ad\u6cbb\u7597\u5e76\u964d\u4f4e\u672c\u54c1\u7684\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e38\u89c1\u4e0d\u826f\u4e8b\u4ef6\uff08\u2265<span>10%<\/span>\uff09\u4e3a<span>ALT<\/span>\u5347\u9ad8\u3001<span>AST<\/span>\u5347\u9ad8\u3001\u8d2b\u8840\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u6027\u53d1\u70ed\u3001\u8840\u5c0f\u677f\u8ba1\u6570\u51cf\u5c11\u3001\u8179\u6cfb\u3001\u6076\u5fc3\u3001\u8840\u78b1\u6027\u78f7\u9178\u9176\u5347\u9ad8\u3001\u75b2\u4e4f\u3001\u767d\u7ec6\u80de\u8ba1\u6570\u51cf\u5c11\u3001\u8840\u808c\u9178\u78f7\u9178\u6fc0\u9176\u5347\u9ad8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u4e3b\u8981\u7ecf<span>CYP3A4<\/span>\u9176\u4ee3\u8c22\uff0c\u5e94\u907f\u514d\u4e0e\u5f3a\u6548<span>CYP3A\/P-<\/span>\u7cd6\u86cb\u767d\u8bf1\u5bfc\u5242\u8054\u5408\u4f7f\u7528\u3002\u4e0e\u5f3a\u6548<span>CYP3A<\/span>\u548c<span>\/<\/span>\u6216<span>P-<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\u65f6\uff0c\u672c\u54c1\u7684\u66b4\u9732\u91cf\u589e\u52a0\u7ea6<span>1.5<\/span>\u500d\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u53ef\u80fd\u964d\u4f4e\u9776\u5411<span>5HT2B<\/span>\u53d7\u4f53\u6216\u03c3\u975e\u7279\u5f02\u6027\u53d7\u4f53\u7684\u836f\u7269\uff08\u5982\u827e\u53f8\u897f\u915e\u666e\u5170\u3001\u6c1f\u897f\u6c40\u3001\u820d\u66f2\u6797\uff09\u7684\u7597\u6548\u3002\u9664\u975e\u786e\u8ba4\u60a3\u8005\u83b7\u76ca\u5927\u4e8e\u98ce\u9669\uff0c\u5426\u5219\u5e94\u907f\u514d\u8fd9\u4e9b\u836f\u7269\u4e0e\u672c\u54c1\u7684\u8054\u5408\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u4e0d\u5efa\u8bae\u5728\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u4f7f\u7528\u672c\u54c1\uff0c\u56e0\u4e3a\u5c1a\u672a\u5728\u8be5\u4eba\u7fa4\u4e2d\u8fdb\u884c\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u8bc4\u4ef7\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">12.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u7fa4\u4f53\u836f\u4ee3\u52a8\u529b\u5b66\u6a21\u578b\u8bc4\u4ef7\uff0c\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u5c1a\u65e0\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u4e34\u5e8a\u7ecf\u9a8c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e94\u3001\u4f0a\u5e03\u66ff\u5c3c<span> Ibrutinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>140mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5355\u836f\u9002\u7528\u4e8e\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">MCL<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff09<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5355\u836f\u6cbb\u7597\u521d\u6cbb\u53ca\u590d\u53d1\u7684\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5<span>\/<\/span>\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5355\u836f\u6216\u4e0e\u5229\u59a5\u6614\u5355\u6297\u8054\u5408\u6cbb\u7597\u521d\u6cbb\u53ca\u590d\u53d1\u7684\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u5e03\u66ff\u5c3c\u7528\u4e8e<span>CLL<\/span>\u6cbb\u7597\u524d\uff0c\u5e94\u8fdb\u884c\u4e25\u683c\u4e34\u5e8a\u8bc4\u4f30\uff0c\u5982\u679c\u60a3\u8005\u6709\u660e\u786e<span>del<\/span>\uff08<span>17p<\/span>\uff09\uff0c\u9009<span>BTK<\/span>\u6291\u5236\u5242\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u8bca\u65ad\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u6216\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u6216\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff0c\u6839\u636e\u8bca\u65ad\u4e0d\u540c\uff0c\u6cbb\u7597\u5242\u91cf\u4e0d\u540c\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u8be5\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\u8bc4\u4f30\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u53cd\u5e94\u53ca\u6bd2\u6027\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597<span>MCL<\/span>\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>560mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\uff1b\u6cbb\u7597<span>CLL\/SLL<\/span>\u548c\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>420mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u63a8\u8350\u5242\u91cf\u662f\u6bcf\u5929<span>140mg<\/span>\u3002\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u907f\u514d\u4f7f\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53e3\u670d\u7ed9\u836f\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u6bcf\u5929\u7684\u7528\u836f\u65f6\u95f4\u5927\u81f4\u56fa\u5b9a\u3002\u5e94\u7528\u6c34\u9001\u670d\u6574\u7c92\u80f6\u56ca\u3002\u8bf7\u52ff\u6253\u5f00\u3001\u5f04\u7834\u6216\u5480\u56bc\u80f6\u56ca\u3002\u5982\u679c\u672a\u5728\u8ba1\u5212\u65f6\u95f4\u670d\u7528\u672c\u54c1\uff0c\u53ef\u4ee5\u5728\u5f53\u5929\u5c3d\u5feb\u670d\u7528\uff0c\u7b2c\u4e8c\u5929\u7ee7\u7eed\u5728\u6b63\u5e38\u8ba1\u5212\u65f6\u95f4\u670d\u836f\u3002\u8bf7\u52ff\u989d\u5916\u670d\u7528\u672c\u54c1\u4ee5\u5f25\u8865\u6f0f\u670d\u5242\u91cf\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51fa\u73b0\u4efb\u4f55\u2265<span>3<\/span>\u7ea7\u975e\u8840\u6db2\u5b66\u6bd2\u6027\u3001\u2265<span>3<\/span>\u7ea7\u4f34\u611f\u67d3\u6216\u53d1\u70ed\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u6216\u8005<span>4<\/span>\u7ea7\u8840\u6db2\u5b66\u6bd2\u6027\u65f6\uff0c\u5e94\u4e2d\u65ad\u6cbb\u7597\u3002\u5f85\u6bd2\u6027\u75c7\u72b6\u6d88\u9000\u81f3<span>1<\/span>\u7ea7\u6216\u57fa\u7ebf\u6c34\u5e73\uff08\u6062\u590d\uff09\u65f6\uff0c\u53ef\u4ee5\u8d77\u59cb\u5242\u91cf\u91cd\u65b0\u5f00\u59cb\u6cbb\u7597\u3002\u5982\u679c\u8be5\u6bd2\u6027\u518d\u6b21\u53d1\u751f\uff0c\u5e94\u5c06\u5242\u91cf\u51cf\u5c11<span>140mg<\/span>\uff0c\u5982\u6709\u9700\u8981\uff0c\u53ef\u4ee5\u8003\u8651\u518d\u51cf\u5c11<span>140mg<\/span>\u3002\u5982\u679c\u5728\u4e24\u6b21\u5242\u91cf\u964d\u4f4e\u540e\u8be5\u6bd2\u6027\u4ecd\u7136\u5b58\u5728\u6216\u518d\u6b21\u53d1\u751f\uff0c\u5e94\u505c\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a5\u53d7\u672c\u836f\u6cbb\u7597\u7684<span>MCL<\/span>\u60a3\u8005\u6700\u5e38\u53d1\u751f\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u2265<span>20%<\/span>\uff09\u662f\u8179\u6cfb\u3001\u51fa\u8840\uff08\u5982\u9752\u80bf\uff09\u3001\u75b2\u4e4f\u3001\u9aa8\u9abc\u808c\u8089\u75bc\u75db\u3001\u6076\u5fc3\u3001\u4e0a\u547c\u5438\u9053\u611f\u67d3\u3001\u54b3\u55fd\u548c\u76ae\u75b9\u3002\u6700\u5e38\u89c1\u7684<span>3<\/span>\u7ea7\u6216<span>4<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff08\u2265<span>5%<\/span>\uff09\u662f\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3001\u611f\u67d3\u6027\u80ba\u708e\u548c\u8d2b\u8840\u3002\u63a5\u53d7\u672c\u836f\u6cbb\u7597\u7684<span>CLL<\/span>\u6216<span>SLL<\/span>\u60a3\u8005\u6700\u5e38\u53d1\u751f\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u2265<span>20%<\/span>\uff09\u662f\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3001\u8d2b\u8840\u3001\u8179\u6cfb\u3001\u9aa8\u9abc\u808c\u8089\u75bc\u75db\u3001\u6076\u5fc3\u3001\u76ae\u75b9\u3001\u9752\u80bf\u3001\u75b2\u4e4f\u3001\u53d1\u70ed\u548c\u51fa\u8840\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u516d\u3001\u8d1d\u6797\u59a5\u6b27\u5355\u6297<span> Blinatumomab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7c89\u9488\u5242\uff1a<span>35<\/span>\u03bc<span>g\/<\/span>\u74f6\uff0c\u53e6\u5305\u542b<span>1<\/span>\u74f6<span>10ml<\/span>\u9759\u8109\u8f93\u6ce8\u6eb6\u6db2\u7a33\u5b9a\u5242<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u7528\u4e8e\u6210\u4eba\u590d\u53d1\u6216\u96be\u6cbb\u6027\u524d\u4f53<span>B<\/span>\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u5242\u91cf\uff1a\u2265<span>45kg<\/span>\u4f53\u91cd\u7684\u60a3\u8005\u63a5\u53d7\u56fa\u5b9a\u5242\u91cf\u7ed9\u836f\uff0c\uff1c<span>45kg<\/span>\u4f53\u91cd\u7684\u60a3\u8005\u6839\u636e\u4f53\u8868\u9762\u79ef\u8ba1\u7b97\u5242\u91cf\u3002\u96be\u6cbb\u53ca\u590d\u53d1\u75be\u75c5\u7684\u60a3\u8005\u9700\u5728\u7b2c\u4e00\u6cbb\u7597\u5468\u671f\u7684\u7b2c<span>1<\/span>\uff5e<span>7<\/span>\u5929\u4ece\u4f4e\u5242\u91cf\u8d77\u59cb\uff0c\u4f53\u91cd\u2265<span>45kg<\/span>\u8005\u7ed9\u4e88\u56fa\u5b9a\u5242\u91cf<span>9<\/span>\u03bc<span>g\/d<\/span>\uff0c\uff1c<span>45kg<\/span>\u8005\u6839\u636e\u4f53\u8868\u9762\u79ef\u7ed9\u4e88<span>5<\/span>\u03bc<span>g\/<\/span>\uff08<span>m<sup>2<\/sup><\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2022<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">d<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff09\uff1b\u7b2c<span>8<\/span>\u5929\u8d77\u81f3\u7b2c<span>28<\/span>\u5929\u589e\u52a0\u81f3\u8db3\u5242\u91cf\u5373\u2265<span>45kg<\/span>\u8005<span>28<\/span>\u03bc<span>g\/d<\/span>\uff0c\uff1c<span>45kg<\/span>\u8005<span>15<\/span>\u03bc<span>g\/<\/span>\uff08<span>m<sup>2<\/sup><\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2022<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">d<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff09\u3002\u7528\u4e8e\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\u9633\u6027\u60a3\u8005\u65e0\u9700\u7ecf\u8fc7\u5242\u91cf\u722c\u5761\uff0c\u8d77\u59cb\u5373\u7ed9\u4e88\u8db3\u5242\u91cf<span>28<\/span>\u03bc<span>g\/d<\/span>\uff08\u2265<span>45kg<\/span>\uff09\u6216<span>15<\/span>\u03bc<span>g\/<\/span>\uff08<span>m<sup>2<\/sup><\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2022<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">d<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff09\uff08\uff1c<span>45kg<\/span>\uff09\u3002\u5982\u6cbb\u7597\u671f\u95f4\u51fa\u73b0\u4e2d\u65ad\u7ed9\u836f\uff08\u5982\u56e0\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\uff09\uff0c\u672a\u8d85\u8fc7<span>7<\/span>\u5929\u53ef\u7ee7\u7eed\u8be5\u5468\u671f\u6cbb\u7597\u76f4\u81f3\u5171\u8f93\u6ce8<span>28<\/span>\u5929\uff0c\u4e2d\u65ad\u7ed9\u836f\u8d85\u8fc7<span>7<\/span>\u5929\u5219\u9700\u91cd\u65b0\u5f00\u59cb\u65b0\u7684\u6cbb\u7597\u5468\u671f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u7597\u7a0b\uff1a\u96be\u6cbb\u53ca\u590d\u53d1\u75be\u75c5\u60a3\u8005\u7684\u7597\u7a0b\u6700\u591a\u5305\u542b<span>2<\/span>\u4e2a\u5468\u671f\u7684\u8bf1\u5bfc\u6cbb\u7597\u3001\u4e4b\u540e<span>3<\/span>\u4e2a\u5468\u671f\u7684\u5de9\u56fa\u6cbb\u7597\u53ca\u5e8f\u8d2f\u6700\u591a<span>4<\/span>\u4e2a\u5468\u671f\u7684\u6301\u7eed\u6cbb\u7597\u3002<span>1<\/span>\u4e2a\u8bf1\u5bfc\u6216\u5de9\u56fa\u6cbb\u7597\u5468\u671f\u5171<span>42<\/span>\u5929\uff0c\u7531<span>28<\/span>\u5929\u8fde\u7eed\u7684\u9759\u8109\u8f93\u6ce8\u671f\u548c\u968f\u540e\u7684<span>14<\/span>\u5929\u65e0\u6cbb\u7597\u95f4\u6b47\u671f\u7ec4\u6210\uff0c<span>1<\/span>\u4e2a\u6301\u7eed\u6cbb\u7597\u5468\u671f\u5305\u62ec<span>28<\/span>\u5929\u8fde\u7eed\u9759\u8109\u8f93\u6ce8\u548c\u4e4b\u540e\u7684<span>56<\/span>\u5929\u65e0\u6cbb\u7597\u95f4\u6b47\u671f\uff08\u5171<span>84<\/span>\u5929\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5730\u585e\u7c73\u677e\u9884\u5148\u7528\u836f\uff1a\u5bf9\u4e8e\u6210\u4eba\u60a3\u8005\uff0c\u5728\u672c\u54c1\u6bcf\u4e2a\u5468\u671f\u5185\u7b2c\u4e00\u6b21\u7ed9\u836f\u524d<span>1<\/span>\u5c0f\u65f6\uff0c\u5347\u9ad8\u5242\u91cf\u524d\uff08\u4f8b\u5982\u7b2c<span>1<\/span>\u5468\u671f\u7b2c<span>8<\/span>\u5929\uff09\uff0c\u4ee5\u53ca\u5728\u4e2d\u65ad\u6cbb\u7597<span>4<\/span>\u5c0f\u65f6\u6216\u4ee5\u4e0a\u540e\u91cd\u542f\u8f93\u6ce8\u65f6\uff0c\u7528\u836f\u524d\u9884\u5148\u7ed9\u4e88<span>20mg<\/span>\u7684\u5730\u585e\u7c73\u677e\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9ad8\u80bf\u7624\u8d1f\u8377\u60a3\u8005\u7684\u524d\u671f\u6cbb\u7597\uff1a\u5bf9\u4e8e\u9aa8\u9ad3\u4e2d\u539f\u59cb\u7ec6\u80de\u6bd4\u4f8b\u2265<span>50%<\/span>\u6216\u5916\u5468\u8840\u539f\u59cb\u7ec6\u80de\u8ba1\u6570\uff1e<span>15<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u7684\u60a3\u8005\uff0c\u4f7f\u7528\u5730\u585e\u7c73\u677e\u6cbb\u7597\uff08\u4e0d\u8d85\u8fc7<span>24mg\/d<\/span>\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u672c\u54c1\u6cbb\u7597\u524d\u548c\u6cbb\u7597\u671f\u95f4\u8fdb\u884c\u9798\u5185\u6ce8\u5c04\u9884\u9632\u6027\u5316\u7597\uff0c\u4ee5\u9632\u6b62\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u590d\u53d1\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u7684\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u5c1a\u65e0\u8d1d\u6797\u59a5\u6b27\u5355\u6297\u7528\u4e8e\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\uff08\u808c\u9150\u6e05\u9664\u7387\uff1c<span>30ml\/min<\/span>\uff09\u6216\u6b63\u63a5\u53d7\u8840\u6db2\u900f\u6790\u7684\u60a3\u8005\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u4fe1\u606f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d1d\u6797\u59a5\u6b27\u5355\u6297\u5f00\u59cb\u6cbb\u7597\u65f6\u5bfc\u81f4\u7684\u7ec6\u80de\u56e0\u5b50\u77ed\u6682\u91ca\u653e\u53ef\u80fd\u4f1a\u6291\u5236<span>CYP450<\/span>\u9176\u3002\u5728\u5408\u5e76\u4f7f\u7528<span>CYP450<\/span>\u5e95\u7269\uff08\u5c24\u5176\u662f\u5177\u6709\u72ed\u7a84\u6cbb\u7597\u6307\u6570\u7684<span>CYP450<\/span>\u5e95\u7269\uff09\u7684\u60a3\u8005\u4e2d\uff0c\u7b2c<span>1<\/span>\u5468\u671f\u524d<span>9<\/span>\u5929\u548c\u7b2c<span>2<\/span>\u5468\u671f\u524d<span>2<\/span>\u5929\u53d1\u751f\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u7684\u98ce\u9669\u6700\u9ad8\u3002\u5e94\u5f53\u76d1\u6d4b\u8fd9\u4e9b\u60a3\u8005\u4e2d\u7684\u6bd2\u6027\uff08\u5982\u534e\u6cd5\u6797\uff09\u6216\u836f\u7269\u6d53\u5ea6\uff08\u5982\u73af\u5b62\u9709\u7d20\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff1a\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5728<span>15%<\/span>\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u60a3\u8005\u548c<span>7%<\/span>\u7684\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\u9633\u6027\u7684\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u60a3\u8005\u62a5\u544a\u4e86\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\u3002\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\u53d1\u751f\u4e2d\u4f4d\u65f6\u95f4\u4e3a\u8f93\u6ce8\u5f00\u59cb\u540e<span>2<\/span>\u5929\uff0c\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\u6d88\u9000\u4e2d\u4f4d\u65f6\u95f4\u4e3a<span>5<\/span>\u5929\u3002\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\u7684\u8868\u73b0\u5305\u62ec\u53d1\u70ed\u3001\u5934\u75db\u3001\u6076\u5fc3\u3001\u4e4f\u529b\u3001\u4f4e\u8840\u538b\u3001<span>ALT<\/span>\u5347\u9ad8\u3001<span>AST<\/span>\u5347\u9ad8\u3001\u603b\u80c6\u7ea2\u7d20\u5347\u9ad8\u4ee5\u53ca\u5f25\u6563\u6027\u8840\u7ba1\u5185\u51dd\u8840\u7b49\u3002\u63a5\u53d7\u8d1d\u6797\u59a5\u6b27\u5355\u6297\u6cbb\u7597\u540e\u7684\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\u7684\u8868\u73b0\u4e0e\u8f93\u6db2\u53cd\u5e94\u3001\u6bdb\u7ec6\u8840\u7ba1\u6e17\u6f0f\u7efc\u5408\u5f81\u548c\u566c\u8840\u7ec6\u80de\u6027\u7ec4\u7ec7\u7ec6\u80de\u589e\u751f\u75c7<span>\/<\/span>\u5de8\u566c\u7ec6\u80de\u6fc0\u6d3b\u7efc\u5408\u5f81\u7684\u8868\u73b0\u91cd\u53e0\u3002\u5927\u591a\u6570\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\u662f\u53ef\u9006\u7684\uff0c\u5e76\u4e14\u53ef\u5728\u8d1d\u6797\u59a5\u6b27\u5355\u6297\u7ed9\u836f\u524d\u901a\u8fc7\u8bc6\u522b\u9ad8\u5371\u75c5\u4eba\u3001\u5730\u585e\u7c73\u677e\u9884\u5148\u7528\u836f\u53ca\u9010\u6b65\u589e\u52a0\u5242\u91cf\u7684\u7ed9\u836f\u65b9\u5f0f\u8fdb\u884c\u9884\u9632\u3002\u4f4e\u7ea7\u522b\uff08<span>1<\/span>\uff5e<span>2<\/span>\u7ea7\uff09\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\u65e0\u9700\u6682\u505c\u8d1d\u6797\u59a5\u6b27\u5355\u6297\u7528\u836f\uff0c\u53ef\u5728\u5bc6\u5207\u76d1\u6d4b\u76f8\u5173\u6307\u6807\u53ca\u751f\u547d\u4f53\u5f81\u4e0b\u7ed9\u4e88\u5bf9\u75c7\u6cbb\u7597\u3002\u5bf9\u4e8e\u4e25\u91cd\uff08\u2265<span>3<\/span>\u7ea7\uff09\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff0c<span>3<\/span>\u7ea7\u9700\u6682\u505c\u7ed9\u836f\uff0c<span>4<\/span>\u7ea7\u8003\u8651\u6c38\u4e45\u505c\u836f\uff0c\u5e76\u9700\u8981\u4e25\u5bc6\u76d1\u6d4b\u751f\u547d\u4f53\u5f81\u5e76\u8fc5\u901f\u7ed9\u4e88\u79ef\u6781\u7684\u6cbb\u7597\uff0c\u6839\u636e\u4e34\u5e8a\u6307\u5f81\u7ed9\u4e88\u7cd6\u76ae\u8d28\u6fc0\u7d20\uff08\u9996\u9009\u5730\u585e\u7c73\u677e\uff09\u548c<span>IL-6<\/span>\u53d7\u4f53\u963b\u6ede\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u795e\u7ecf\u7cfb\u7edf\u6bd2\u6027\uff1a\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u795e\u7ecf\u7cfb\u7edf\u6bd2\u6027\u53d1\u751f\u4e8e\u5927\u7ea6<span>65%<\/span>\u7684\u60a3\u8005\u3002\u53d1\u751f\u9996\u9879\u4e8b\u4ef6\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a\u672c\u54c1\u6cbb\u7597\u7684\u524d<span>2<\/span>\u5468\u5185\uff0c\u5927\u591a\u6570\u795e\u7ecf\u7cfb\u7edf\u4e8b\u4ef6\u53ef\u4ee5\u6d88\u9000\u3002\u795e\u7ecf\u7cfb\u7edf\u6bd2\u6027\u7684\u6700\u5e38\u89c1\uff08\u2265<span>10%<\/span>\uff09\u8868\u73b0\u4e3a\u5934\u75db\u548c\u9707\u98a4\uff1b\u795e\u7ecf\u7cfb\u7edf\u6bd2\u6027\u7684\u7279\u5f81\u56e0\u5e74\u9f84\u7ec4\u800c\u5f02\u3002\u5f00\u59cb\u672c\u54c1\u7ed9\u836f\u540e\uff0c\u5927\u7ea6<span>13%<\/span>\u7684\u60a3\u8005\u53d1\u751f\u2265<span>3<\/span>\u7ea7\uff08\u4e25\u91cd\u3001\u5371\u53ca\u751f\u547d\u6216\u5bfc\u81f4\u6b7b\u4ea1\uff09\u7684\u795e\u7ecf\u7cfb\u7edf\u6bd2\u6027\uff0c\u5305\u62ec\u8111\u75c5\u3001\u62bd\u6410\u3001\u8a00\u8bed\u969c\u788d\u3001\u610f\u8bc6\u969c\u788d\u3001\u5b9a\u5411\u969c\u788d\u3001\u534f\u8c03\u969c\u788d\u548c\u5e73\u8861\u969c\u788d\u3002\u795e\u7ecf\u7cfb\u7edf\u6bd2\u6027\u7684\u8868\u73b0\u5305\u62ec\u9885\u795e\u7ecf\u75be\u75c5\u3002\u6240\u6709\u2265<span>3<\/span>\u7ea7\u7684\u795e\u7ecf\u7cfb\u7edf\u6bd2\u6027\u5747\u5e94\u6682\u505c\u7ed9\u836f\u5e76\u8fdb\u884c\u4f53\u683c\u68c0\u67e5\u3001\u751f\u547d\u4f53\u5f81\u76d1\u6d4b\u53ca\u5b89\u5168\u6027\u76f8\u5173\u5b9e\u9a8c\u5ba4\u68c0\u67e5\uff0c\u540c\u65f6\u6839\u636e\u60a3\u8005\u60c5\u51b5\u7ed9\u4e88\u5730\u585e\u7c73\u677e\u6cbb\u7597\uff0c\u6bcf\u5929\u6700\u5927\u5242\u91cf\u4e0d\u8d85\u8fc7<span>24mg\/d<\/span>\uff0c\u5730\u585e\u7c73\u677e\u51cf\u91cf\u65f6\u5e94\u4e8e<span>4<\/span>\u5929\u5185\u5b8c\u6210\u51cf\u91cf\u76f4\u81f3\u505c\u836f\u3002\u652f\u6301\u6027\u6cbb\u7597\u5982\u766b\u75eb\u53d1\u4f5c\u7684\u6297\u766b\u75eb\u836f\u5e94\u7531\u4e13\u79d1\u533b\u751f\u5224\u65ad\u540e\u914c\u60c5\u8003\u8651\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5176\u4ed6\u6cbb\u7597\uff1a\u8d1d\u6797\u59a5\u6b27\u5355\u6297\u53ef\u4ee5\u7528\u4e8e<span>CR1<\/span>\u6216<span>CR2<\/span>\u4f34\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\u9633\u6027\u7684\u6210\u4eba\u53ca\u513f\u7ae5\u524d\u4f53<span>B<\/span>\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u60a3\u8005\uff0c\u4ee5\u53ca\u513f\u7ae5\u590d\u53d1\u6216\u96be\u6cbb\u6027\u524d\u4f53<span>B<\/span>\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08\u5168\u7403\u5176\u4ed6\u56fd\u5bb6\u5df2\u83b7\u6279\u7684\u9002\u5e94\u8bc1\uff09\u3002\u540c\u65f6\u5df2\u6709\u4e0e\u4e8c\u4ee3\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u8fbe\u6c99\u66ff\u5c3c\u8054\u5408\u7528\u4e8e\u65b0\u8bca\u65ad\u7684\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u7684\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08\u2161\u671f\u4e34\u5e8a\u7814\u7a76\uff09\uff0c\u53ca\u4e0e\u4e09\u4ee3\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u535a\u7eb3\u66ff\u5c3c\u8054\u5408\u7528\u4e8e\u65b0\u8bca\u65ad\u53ca\u590d\u53d1\u6216\u96be\u6cbb\u6027\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u7684\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08\u2161\u671f\u4e34\u5e8a\u7814\u7a76\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e03\u3001\u7ef4\u5948\u514b\u62c9 <span>Venetoclax<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>10mg<\/span>\u3001<span>50mg<\/span>\u3001<span>100mg <\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0e\u963f\u624e\u80de\u82f7\u8054\u5408\u7528\u4e8e\u6cbb\u7597\u56e0\u5408\u5e76\u75c7\u4e0d\u9002\u5408\u63a5\u53d7\u5f3a\u8bf1\u5bfc\u5316\u7597\uff0c\u6216\u8005\u5e74\u9f84\u2265<span>75<\/span>\u5c81\u7684\u65b0\u8bca\u65ad\u7684\u6210\u4eba\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u4e0e\u963f\u624e\u80de\u82f7\u8054\u7528\u6cbb\u7597\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff0c\u5728\u7b2c<span>1<\/span>\u4e2a\u7597\u7a0b\u5f00\u59cb\u65f6\uff0c\u672c\u54c1\u9700\u8981\u8fdb\u884c\u5242\u91cf\u722c\u5761\uff0c\u5177\u4f53\u65b9\u6cd5\u662f\uff1a\u7ef4\u5948\u514b\u62c9<span>100mg d1<\/span>\uff0c<span>200mg d2<\/span>\uff0c<span>400mgd3<\/span>\uff0c\u540e<span>400mg\/d<\/span>\u7ee7\u7eed\u6cbb\u7597\uff0c\u6bcf\u7597\u7a0b<span>28<\/span>\u5929\u3002\u672c\u54c1\u6309\u7597\u7a0b\u4e0e\u963f\u624e\u80de\u82f7\u8054\u7528\u7ed9\u836f\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u53d1\u751f\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5e94\u5728\u9910\u540e<span>30<\/span>\u5206\u949f\u5185\u670d\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5e94\u5c3d\u53ef\u80fd\u5728\u6bcf\u5929\u540c\u4e00\u65f6\u95f4\u670d\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5e94\u6574\u7247\u541e\u670d\uff0c\u4e0d\u5f97\u5480\u56bc\u3001\u78be\u788e\u6216\u5728\u541e\u670d\u524d\u63b0\u788e\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u60a3\u8005\u5728\u5e38\u89c4\u670d\u836f\u65f6\u95f4\u7684<span>8<\/span>\u5c0f\u65f6\u5185\u6f0f\u670d\u4e00\u6b21\u672c\u54c1\uff0c\u5e94\u5c3d\u5feb\u8865\u670d\uff0c\u5e76\u6062\u590d\u6bcf\u5929\u5e38\u89c4\u7ed9\u836f\u3002\u82e5\u60a3\u8005\u6f0f\u670d\u672c\u54c1\u5df2\u8d85\u8fc7<span>8<\/span>\u5c0f\u65f6\uff0c\u5219\u4e0d\u9700\u8981\u8865\u670d\uff0c\u53ea\u9700\u5728\u7b2c\u4e8c\u5929\u6062\u590d\u5e38\u89c4\u7ed9\u836f\u3002\u5982\u60a3\u8005\u5728\u6b63\u5e38\u7ed9\u836f\u540e\u53d1\u751f\u5455\u5410\uff0c\u5728\u5455\u5410\u5f53\u5929\u4e0d\u9700\u8981\u518d\u6b21\u670d\u7528\u672c\u54c1\uff0c\u5728\u5e38\u89c4\u670d\u836f\u65f6\u95f4\u8fdb\u884c\u4e0b\u6b21\u7ed9\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5728<span>AML<\/span>\u60a3\u8005\u4e2d\u53d1\u751f\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\u98ce\u9669\u76f8\u5bf9\u8f83\u4f4e\uff0c\u4f46\u4ecd\u5e94\u4e88\u4ee5\u8db3\u591f\u91cd\u89c6\u3002\u5efa\u8bae\u5728\u672c\u54c1\u7ed9\u836f\u524d\uff0c\u60a3\u8005\u7684\u767d\u7ec6\u80de\u8ba1\u6570\u5e94\u5c0f\u4e8e<span>25\u00d710<sup>9<\/sup>\/L<\/span>\uff0c\u7ea0\u6b63\u7d0a\u4e71\u7684\u7535\u89e3\u8d28\u3002\u5728\u9996\u6b21\u7ed9\u836f\u524d\u4ee5\u53ca\u5242\u91cf\u722c\u5761\u671f\uff0c\u5e94\u7ed9\u4e88\u5145\u8db3\u7684\u6c34\u5316\u548c\u6297\u9ad8\u5c3f\u9178\u8840\u75c7\u836f\u7269\u3002\u722c\u5761\u671f\u5185\u6bcf\u6b21\u65b0\u5242\u91cf\u7ed9\u836f\u540e<span>6<\/span>\uff5e<span>8<\/span>\u5c0f\u65f6\u4ee5\u53ca\u8fbe\u5230\u6700\u7ec8\u5242\u91cf\u540e<span>24<\/span>\u5c0f\u65f6\uff0c\u5e94\u76d1\u6d4b\u8840\u751f\u5316\u4ee5\u8bc4\u4f30\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\u3002\u5bf9\u4e8e\u6709\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\u98ce\u9669\u7684\u60a3\u8005\uff0c\u53ef\u7ed9\u4e88\u989d\u5916\u63aa\u65bd\u52a0\u5f3a\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\u9884\u9632\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8840\u6db2\u5b66\u6bd2\u6027\u662f\u7ef4\u5948\u514b\u62c9\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u3002\u5728\u8bf1\u5bfc\u6cbb\u7597\u83b7\u5f97\u7f13\u89e3\u524d\uff0c\u5373\u4f7f\u53d1\u751f<span>4<\/span>\u7ea7\u8840\u7ec6\u80de\u51cf\u5c11\uff0c\u4e5f\u4e0d\u5e94\u4e2d\u65ad\u672c\u54c1\u6cbb\u7597\u3002\u5728\u83b7\u5f97\u7f13\u89e3\u540e\u7684\u9996\u4e2a\u7597\u7a0b\u4e2d\u518d\u6b21\u51fa\u73b0<span>4<\/span>\u7ea7\u8840\u7ec6\u80de\u51cf\u5c11\u4e14\u6301\u7eed\u8d85\u8fc7<span>7<\/span>\u5929\uff0c\u4ecd\u5efa\u8bae\u575a\u6301\u8db3\u5242\u91cf\u8db3\u7597\u7a0b\u4f7f\u7528\uff0c\u6cbb\u7597\u7ed3\u675f\u540e\u63a8\u8fdf\u4e0b\u4e00\u7597\u7a0b\u5f00\u59cb\uff0c<a name=\"OLE_LINK4\"><\/a>\u76d1\u6d4b\u8840\u7ec6\u80de\u8ba1\u6570\uff0c\u7b49\u5f85\u8840\u7ec6\u80de\u51cf\u5c11\u6062\u590d\u81f3<span>1<\/span>\u7ea7\u6216<span>2<\/span>\u7ea7\uff0c\u5219\u4ee5\u76f8\u540c\u5242\u91cf\u6062\u590d\u672c\u54c1\u4e0e\u963f\u624e\u80de\u82f7\u7684\u540e\u7eed\u6cbb\u7597\u3002\u82e5\u5728\u540e\u7eed\u7597\u7a0b\u4e2d\u518d\u6b21\u51fa\u73b0<span>4<\/span>\u7ea7\u8840\u7ec6\u80de\u51cf\u5c11\u4e14\u6301\u7eed\u8d85\u8fc7<span>7<\/span>\u5929\uff0c\u53ef\u8003\u8651\u5c06\u7ef4\u5948\u514b\u62c9\u7597\u7a0b\u4ece<span>28<\/span>\u5929\u51cf\u5c11\u81f3<span>21<\/span>\u5929\uff0c\u76d1\u6d4b\u8840\u7ec6\u80de\u8ba1\u6570\uff0c\u7b49\u5f85\u8840\u7ec6\u80de\u51cf\u5c11\u6062\u590d\u81f3<span>1<\/span>\u7ea7\u6216<span>2<\/span>\u7ea7\u518d\u5f00\u59cb\u540e\u7eed\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u4e0e<span>CYP3A<\/span>\u6291\u5236\u5242\u8054\u7528\u65f6\u9700\u8fdb\u884c\u76f8\u5e94\u7684\u8c03\u6574\u5242\u91cf\u3002\u672c\u54c1\u4e0e\u5f3a\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\uff08\u5982\u4f0a\u66f2\u5eb7\u5511\u3001\u4f0f\u7acb\u5eb7\u5511\u3001\u916e\u5eb7\u5511\u7b49\uff09\u8054\u7528\u65f6\uff0c\u7ef4\u5948\u514b\u62c9\u9700\u51cf\u91cf\u81f3<span>100mg\/d<\/span>\uff0c\u82e5\u5904\u4e8e\u5242\u91cf\u722c\u5761\u671f\uff0c\u51cf\u91cf\u65b9\u6cd5\u4e3a\uff1a\u7ef4\u5948\u514b\u62c9<span>10mg d1<\/span>\uff0c<span>20mg d2<\/span>\uff0c<span>50mgd3<\/span>\uff0c<span>100mg d4<\/span>\uff1b\u6cca\u6c99\u5eb7\u5511\u4e5f\u5c5e\u4e8e\u5f3a\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\uff0c\u4f46\u4e0e\u6cca\u6c99\u5eb7\u5511\u8054\u7528\u65f6\uff0c\u7ef4\u5948\u514b\u62c9\u9700\u51cf\u91cf\u81f3<span>70mg\/d<\/span>\uff0c\u82e5\u5904\u4e8e\u5242\u91cf\u722c\u5761\u671f\uff0c\u51cf\u91cf\u65b9\u6cd5\u4e3a\uff1a\u7ef4\u5948\u514b\u62c9<span>10mg d1<\/span>\uff0c<span>20mg d2<\/span>\uff0c<span>50mg d3<\/span>\uff0c<span>70mgd4<\/span>\uff1b\u4e0e\u4e2d\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\uff08\u5982\u6c1f\u5eb7\u5511\u7b49\uff09\u548c<span>P-<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\uff08\u5982\u80fa\u7898\u916e\u3001\u5361\u6258\u666e\u5229\u7b49\uff09\u8054\u7528\u65f6\uff0c\u7ef4\u5948\u514b\u62c9\u9700\u51cf\u91cf<span>50%<\/span>\u3002\u7981\u6b62\u672c\u54c1\u4e0e<span>CYP3A<\/span>\u8bf1\u5bfc\u5242\uff08\u5982\u5229\u798f\u5e73\u3001\u82ef\u59a5\u82f1\u94a0\u3001\u5361\u9a6c\u897f\u5e73\u7b49\uff09\u8054\u5408\u4f7f\u7528\u3002\u672c\u54c1\u4e0e<span>P-<\/span>\u7cd6\u86cb\u767d\u5e95\u7269\uff08\u5982\u5730\u9ad8\u8f9b\u7b49\uff09\u53ca\u534e\u6cd5\u6797\u7b49\u8054\u7528\uff0c\u9700\u5bc6\u5207\u76d1\u6d4b\u5408\u7528\u836f\u7269\u7684\u8840\u836f\u6d53\u5ea6\u3001<span>INR<\/span>\u7b49\u76f8\u5e94\u6307\u6807\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u4e2d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\uff08\u808c\u9150\u6e05\u9664\u7387\u2265<span>15ml\/min<\/span>\uff09\u60a3\u8005\u65e0\u9700\u5242\u91cf\u8c03\u6574\u3002\u8f7b\u5ea6\uff08<span>Child-PughA<\/span>\u7ea7\uff09\u6216\u4e2d\u5ea6\uff08<span>Child-PughB<\/span>\u7ea7\uff09\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\uff08<span>Child-Pugh C<\/span>\u7ea7\uff09\u60a3\u8005\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u65f6\uff0c\u7ed9\u836f\u5242\u91cf\u964d\u4f4e<span>50%<\/span>\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u516b\u3001\u5229\u59a5\u6614\u5355\u6297<span> Rituximab<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6\u3001<span>500mg<\/span>\uff08<span>50ml<\/span>\uff09<span>\/<\/span>\u74f6<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u6cbb\u7597\u6307\u5f81\u7684\u6ee4\u6ce1\u6027\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.CD20<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9633\u6027\u5f25\u6f2b\u5927<span>B<\/span>\u7ec6\u80de\u6027\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08<span>DLBCL<\/span>\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5355\u836f\u7528\u4e8e\u5229\u59a5\u6614\u5355\u6297\u8054\u5408\u5316\u7597\u540e\u8fbe\u5b8c\u5168\u6216\u90e8\u5206\u7f13\u89e3\u540e\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\uff08<span>FL<\/span>\uff09\u60a3\u8005\u7684\u7ef4\u6301\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8054\u5408\u6c1f\u8fbe\u62c9\u6ee8\u548c\u73af\u78f7\u9170\u80fa\uff08<span>FC<\/span>\uff09\u7528\u4e8e\u521d\u6cbb\u590d\u53d1\u6027<span>\/<\/span>\u96be\u6cbb\u6027\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a5\u53d7\u5229\u59a5\u6614\u5355\u6297\u6cbb\u7597\u540e\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u662f\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\uff0c\u4e3b\u8981\u5728\u9996\u6b21\u8f93\u6ce8\u65f6\u53d1\u751f\uff0c\u75c7\u72b6\u53ef\u8868\u73b0\u4e3a\uff1a\u6076\u5fc3\u3001\u7619\u75d2\u3001\u53d1\u70ed\u3001\u98ce\u75b9<span>\/<\/span>\u76ae\u75b9\u3001\u754f\u5bd2\u3001\u5bd2\u6218\u3001\u55b7\u568f\u3001\u8840\u7ba1\u795e\u7ecf\u6027\u6c34\u80bf\u3001\u54bd\u5589\u523a\u6fc0\u3001\u54b3\u55fd\u548c\u652f\u6c14\u7ba1\u75c9\u631b\uff0c\u540c\u65f6\u4f34\u6709\u6216\u4e0d\u4f34\u6709\u4e0e\u836f\u7269\u6cbb\u7597\u76f8\u5173\u7684\u4f4e\u8840\u538b\u6216\u9ad8\u8840\u538b\u3002\u6bcf\u6b21\u6ef4\u6ce8\u5229\u59a5\u6614\u5355\u6297\u524d\u5e94\u9884\u5148\u4f7f\u7528\u6297\u8fc7\u654f\u836f\u7269\u3002\u5982\u679c\u6240\u4f7f\u7528\u7684\u6cbb\u7597\u65b9\u6848\u4e0d\u5305\u62ec\u7cd6\u76ae\u8d28\u6fc0\u7d20\u65f6\uff0c\u8fd8\u5e94\u8be5\u9884\u5148\u4f7f\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u63a5\u53d7\u5229\u59a5\u6614\u5355\u6297\u548c\u6291\u5236\u7ec6\u80de\u589e\u6b96\u836f\u7269\u5316\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u5df2\u62a5\u544a\u53d1\u751f\u4e59\u578b\u809d\u708e\u518d\u6fc0\u6d3b\u7684\u75c5\u4f8b\u3002\u5e94\u5728\u5f00\u59cb\u5229\u59a5\u6614\u5355\u6297\u6cbb\u7597\u524d\u5bf9\u6240\u6709\u60a3\u8005\u6839\u636e\u5f53\u5730\u6307\u5357\u8fdb\u884c\u4e59\u809d\u75c5\u6bd2\u7684\u7b5b\u67e5\uff0c\u81f3\u5c11\u5e94\u5305\u62ec\u4e59\u809d\u8868\u9762\u6297\u539f\u548c\u4e59\u809d\u6838\u5fc3\u6297\u4f53\u6307\u6807\u3002\u4e0d\u5e94\u5bf9\u6d3b\u52a8\u6027\u4e59\u809d\u60a3\u8005\u4f7f\u7528\u5229\u59a5\u6614\u5355\u6297\u8fdb\u884c\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7981\u7528\u4e8e\u4e25\u91cd\u6d3b\u52a8\u6027\u611f\u67d3\u6216\u514d\u75ab\u5e94\u7b54\u4e25\u91cd\u635f\u4f24\uff08\u5982\u4f4e\u7403\u86cb\u767d\u8840\u75c7\uff0c<span>CD4<\/span>\u6216<span>CD8<\/span>\u7ec6\u80de\u8ba1\u6570\u4e25\u91cd\u4e0b\u964d\uff09\u60a3\u8005\u53ca\u4e25\u91cd\u5fc3\u8870<span>[<\/span>\u7ebd\u7ea6\u5fc3\u810f\u75c5\u5b66\u4f1a\uff08<span>NYHA<\/span>\uff09\u5206\u7c7b<a name=\"_Hlk59362002\"><\/a>\u2163\u7ea7<span>]<\/span>\u60a3\u8005\uff1b\u598a\u5a20\u671f\u95f4\u7981\u6b62\u5229\u59a5\u6614\u5355\u6297\u4e0e\u7532\u6c28\u8776\u5464\u8054\u5408\u7528\u836f\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5229\u59a5\u6614\u5355\u6297\u7ed9\u836f\u9700\u8981\u4e25\u683c\u9075\u5faa\u8bf4\u660e\u4e66\u7528\u6cd5\u7528\u91cf\uff0c\u5c24\u5176\u9700\u8981\u6ce8\u610f\u8d77\u59cb\u6ef4\u901f\u7684\u63a7\u5236\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u7528\u836f\u60a3\u8005\u8fdb\u884c\u4e25\u5bc6\u76d1\u62a4\uff0c\u76d1\u6d4b\u662f\u5426\u53d1\u751f\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\u53ca\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9884\u5148\u5b58\u5728\u80ba\u529f\u80fd\u4e0d\u5168\u6216\u80bf\u7624\u80ba\u6d78\u6da6\u7684\u60a3\u8005\u5fc5\u987b\u8fdb\u884c\u80f8\u90e8\u5f71\u50cf\u5b66\u68c0\u67e5\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f7f\u7528\u5229\u59a5\u6614\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u4e0d\u5b9c\u4f7f\u7528\u6d3b\u75c5\u6bd2\u75ab\u82d7\u8fdb\u884c\u63a5\u79cd\uff0c\u53ef\u4ee5\u63a5\u53d7\u975e\u6d3b\u75ab\u82d7\u7684\u63a5\u79cd\uff0c\u4f46\u5bf9\u975e\u6d3b\u75ab\u82d7\u7684\u5e94\u7b54\u7387\u53ef\u80fd\u4f1a\u4e0b\u964d\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e5d\u3001\u7ef4\u5e03\u59a5\u6614\u5355\u6297 <span>BrentuximabVedotin<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7c89\u9488\u5242\uff1a<span>50mg\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027\u7cfb\u7edf\u6027\u95f4\u53d8\u6027\u5927\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u3002\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5468\u56f4\u795e\u7ecf\u75c5\u53d8\uff1a\u7ef4\u5e03\u59a5\u6614\u5355\u6297\u6cbb\u7597\u53ef\u5f15\u8d77\u611f\u89c9\u548c\u8fd0\u52a8\u6027\u5468\u56f4\u795e\u7ecf\u75c5\u53d8\u4e14\u5177\u6709\u7d2f\u79ef\u6548\u5e94\uff0c\u53ef\u80fd\u9700\u8981\u63a8\u8fdf\u7ed9\u836f\u6216\u7ec8\u6b62\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\uff1a\u5355\u836f\u6cbb\u7597\u8f93\u6db2\u53cd\u5e94\u53d1\u751f\u7387\u4e3a<span>13%<\/span>\uff0c<span>3<\/span>\u7ea7\u4e8b\u4ef6\u53d1\u751f\u7387<span>9.8%<\/span>\u3002\u8d85\u654f\u53cd\u5e94\u53d1\u751f\u5c11\u89c1\uff0c\u5982\u53d1\u751f\u5e94\u7acb\u5373\u7ec8\u6b62\u8f93\u6ce8\u5e76\u7ed9\u4e88\u76f8\u5e94\u5904\u7406\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8840\u6db2\u6bd2\u6027\uff1a\u6bcf\u6b21\u7ed9\u836f\u524d\uff0c\u5e94\u76d1\u6d4b\u5168\u8840\u7ec6\u80de\u8ba1\u6570\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\uff1a\u80bf\u7624\u589e\u6b96\u8fc5\u901f\u548c\u80bf\u7624\u8d1f\u8377\u9ad8\u7684\u60a3\u8005\u53d1\u751f\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\u7684\u98ce\u9669\u8f83\u9ad8\uff0c\u5e94\u5bc6\u5207\u76d1\u6d4b\u5e76\u91c7\u53d6\u9002\u5f53\u7684\u63aa\u65bd\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e25\u91cd\u76ae\u80a4\u53cd\u5e94\uff1a\u5305\u62ec<span>Stevens-Johnson<\/span>\u7efc\u5408\u5f81\u548c\u4e2d\u6bd2\u6027\u8868\u76ae\u574f\u6b7b\u677e\u89e3\u75c7\u3002\u82e5\u53d1\u751f\u5e94\u7ec8\u6b62\u7ef4\u5e03\u59a5\u6614\u5355\u6297\u7ed9\u836f\uff0c\u5e76\u5e94\u63d0\u4f9b\u9002\u5f53\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80ba\u6bd2\u6027\uff1a\u5305\u62ec\u80ba\u708e\u3001\u95f4\u8d28\u6027\u80ba\u708e\u548c\u6025\u6027\u547c\u5438\u7a98\u8feb\u7efc\u5408\u5f81\uff0c\u5e94\u76d1\u6d4b\u5e76\u907f\u514d\u4e0e\u535a\u6765\u9709\u7d20\u5408\u5e76\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ef4\u5e03\u59a5\u6614\u5355\u6297\u4e0e<span>CYP3A4<\/span>\u9014\u5f84\u4ee3\u8c22\u7684\u836f\u7269\u5b58\u5728\u76f8\u4e92\u4f5c\u7528\uff08<span>CYP3A4<\/span>\u6291\u5236\u5242<span>\/<\/span>\u8bf1\u5bfc\u5242\uff09\uff1a\u5982\u4e0e\u916e\u5eb7\u5511\u8054\u7528\u53ef\u80fd\u4f1a\u63d0\u9ad8\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u7684\u53d1\u751f\u7387\uff1b\u5229\u798f\u5e73\u5bf9\u7ef4\u5e03\u59a5\u6614\u5355\u6297\u7684\u8840\u6d46\u66b4\u9732\u91cf\u6ca1\u6709\u5f71\u54cd\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u6bd2\u6027\u589e\u52a0\uff1a\u4e3b\u8981\u662f\u5176\u5171\u4ef7\u8026\u8fde\u7684\u5fae\u7ba1\u6291\u5236\u5242\u5355\u7532\u57fa\u6fb3\u745e\u4ed6\u6c40<span>E<\/span>\u96c6\u805a\u5f15\u8d77\uff0c\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\uff08\u808c\u9150\u6e05\u9664\u7387<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1c<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">30ml\/min<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff09\u60a3\u8005\u907f\u514d\u4f7f\u7528\u7ef4\u5e03\u59a5\u6614\u5355\u6297\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7f8e\u56fd<span>FDA<\/span>\u83b7\u6279\u7684\u5176\u4ed6\u9002\u5e94\u8bc1\uff1a\u5148\u524d\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6cbb\u7597\u7684\u539f\u53d1\u6027\u76ae\u80a4\u95f4\u53d8\u6027\u5927\u7ec6\u80de\u6dcb\u5df4\u7624\u6216<span>CD30<\/span>\u9633\u6027\u8548\u6837\u771f\u83cc\u75c5\u6210\u4eba\u60a3\u8005\uff1b\u8054\u5408\u5316\u7597\u6cbb\u7597\u521d\u6cbb<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2162\u6216<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2163<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u671f\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3001\u521d\u6cbb\u7cfb\u7edf\u6027\u95f4\u53d8\u6027\u5927\u7ec6\u80de\u6dcb\u5df4\u7624\u6216\u5176\u4ed6\u8868\u8fbe<span>CD30<\/span>\u7684\u5916\u5468<span>T<\/span>\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u3001\u897f\u8fbe\u672c\u80fa<span> Chidamide<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>5mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u7528\u4e8e\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u6b21\u5168\u8eab\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u7684\u5916\u5468<span>T<\/span>\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6210\u4eba\u63a8\u8350\u6bcf\u6b21\u670d\u836f<span>30mg<\/span>\uff0c\u6bcf\u5468\u670d\u836f\u4e24\u6b21\uff0c\u4e24\u6b21\u670d\u836f\u95f4\u9694\u4e0d\u5e94\u5c11\u4e8e<span>3<\/span>\u5929\uff08\u5982\u5468\u4e00\u548c\u5468\u56db\u3001\u5468\u4e8c\u548c\u5468\u4e94\u3001\u5468\u4e09\u548c\u5468\u516d\u7b49\uff09\uff0c\u65e9\u9910\u540e<span>30<\/span>\u5206\u949f\u670d\u7528\u3002\u82e5\u75c5\u60c5\u672a\u8fdb\u5c55\u6216\u672a\u51fa\u73b0\u4e0d\u80fd\u8010\u53d7\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5efa\u8bae\u6301\u7eed\u670d\u836f\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u8c03\u6574\uff1a<span>3<\/span>\u7ea7\u6216<span>4<\/span>\u7ea7\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\uff08\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\uff1c<span>1<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff09\u3001\u8840\u5c0f\u677f\u51cf\u5c11\uff08\u8840\u5c0f\u677f\u8ba1\u6570\uff1c<span>50<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff09\u3001\u8d2b\u8840\uff08\u8840\u7ea2\u86cb\u767d\u964d\u4f4e\u81f3\uff1c<span>80g\/L<\/span>\uff09\u65f6\uff0c\u6682\u505c\u7528\u836f\u3002\u5f85\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u503c\u6062\u590d\u81f3\u2265<span>1.5<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u3001\u8840\u5c0f\u677f\u6062\u590d\u81f3\u2265<span>75<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u3001\u8840\u7ea2\u86cb\u767d\u6062\u590d\u81f3\u2265<span>90g\/L<\/span>\uff0c\u5e76\u7ecf\u8fde\u7eed\u4e24\u6b21\u68c0\u67e5\u786e\u8ba4\uff0c\u53ef\u7ee7\u7eed\u6cbb\u7597\u3002\u5982\u4e4b\u524d\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a<span>3<\/span>\u7ea7\uff0c\u6062\u590d\u7528\u836f\u65f6\u53ef\u91c7\u7528\u539f\u5242\u91cf\u6216\u5242\u91cf\u964d\u4f4e\u81f3<span>20mg\/<\/span>\u6b21\uff1b\u5982\u4e4b\u524d\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a<span>4<\/span>\u7ea7\uff0c\u6062\u590d\u7528\u836f\u65f6\u5242\u91cf\u5e94\u964d\u4f4e\u81f3<span>20mg\/<\/span>\u6b21\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u6709\uff1a\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u8840\u5c0f\u677f\u8ba1\u6570\u51cf\u5c11\u3001\u767d\u7ec6\u80de\u6216\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u51cf\u5c11\u3001\u8840\u7ea2\u86cb\u767d\u964d\u4f4e\uff1b\u5168\u8eab\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u4e4f\u529b\u3001\u53d1\u70ed\uff1b\u80c3\u80a0\u9053\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u8179\u6cfb\u3001\u6076\u5fc3\u548c\u5455\u5410\uff1b\u4ee3\u8c22\u53ca\u8425\u517b\u7cfb\u7edf\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u98df\u6b32\u4e0b\u964d\u3001\u4f4e\u94be\u8840\u75c7\u548c\u4f4e\u9499\u8840\u75c7\uff1b\u4ee5\u53ca\u5934\u6655\u3001\u76ae\u75b9\u7b49\uff1b\u6781\u5c11\u6570\u60a3\u8005\u5fc3\u7535\u56fe\u4f1a\u51fa\u73b0<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">QTc<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u95f4\u671f\u5ef6\u957f\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u598a\u5a20\u671f\u5973\u6027\u60a3\u8005\u3001\u4e25\u91cd\u5fc3\u529f\u80fd\u4e0d\u5168\u60a3\u8005\uff08<span>NYHA<\/span>\u5fc3\u529f\u80fd\u4e0d\u5168\u5206\u7ea7\u2163\u7ea7\uff09\u7981\u7528\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e00\u3001\u787c\u66ff\u4f50\u7c73<span> Bortezomib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u5242\uff1a<span>1mg<\/span>\u3001<span>3.5mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u590d\u53d1\u6216\u96be\u6cbb\u6027\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u6216\u65e2\u5f80\u672a\u7ecf\u6cbb\u7597\u7684\u4e14\u4e0d\u9002\u5408\u63a5\u53d7\u9020\u8840\u5e72\u7ec6\u80de\u6818\u690d\u7684\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u6210\u4eba\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u521d\u6cbb\u53ca\u590d\u53d1\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3002<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u5e94\u8003\u8651\u6297\u75c5\u6bd2\u836f\u7269\u7684\u9884\u9632\u6cbb\u7597\uff0c\u964d\u4f4e\u5e26\u72b6\u75b1\u75b9\u518d\u6fc0\u6d3b\u7684\u98ce\u9669\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u542b\u6709\u7518\u9732\u9187\uff0c\u5728\u60a3\u8005\u521d\u6b21\u8bd5\u7528\u836f\u7269\u65f6\uff0c\u9700\u8981\u8be2\u95ee\u8fc7\u654f\u53f2\u53ca\u65e2\u5f80\u75c5\u53f2\uff0c\u8b66\u60d5\u9ad8\u80bf\u7624\u8d1f\u8377\u60a3\u8005\u53d1\u751f\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8ba1\u7b97\u7ed9\u836f\u4f53\u79ef\u9700\u4ed4\u7ec6\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u836f\u7269\u5177\u6709\u7ec6\u80de\u6bd2\u6027\uff0c\u914d\u5236\u65f6\u9700\u8981\u6234\u624b\u5957\u548c\u9632\u62a4\u7528\u54c1\uff0c\u907f\u514d\u76ae\u80a4\u76f4\u63a5\u63a5\u89e6\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4f7f\u7528\u65e0\u9700\u51cf\u91cf\uff0c\u8fdb\u884c\u900f\u6790\u7684\u60a3\u8005\u5e94\u5728\u900f\u6790\u540e\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u795e\u7ecf\u7cfb\u7edf\u75c7\u72b6\uff08\u5305\u62ec\u80a0\u6897\u963b\uff09\u3001\u75c5\u6bd2\u6fc0\u6d3b\u3001\u8840\u6db2\u7cfb\u7edf\u9aa8\u9ad3\u6291\u5236\u7b49\uff0c\u5c11\u89c1\u60c5\u51b5\u8fd8\u53ef\u4ee5\u51fa\u73b0\u6025\u6027\u80ba\u635f\u4f24\u3001\u80f0\u817a\u708e\u7b49\u3002<b><span><\/span><\/b><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u63a8\u8350\u8054\u7528\u5f3a\u6548\u7684<span>CYP3A4<\/span>\u6291\u5236\u5242\u3002\u5982\u679c\u65e0\u6cd5\u907f\u514d\u5408\u5e76\u7528\u836f\uff0c\u5219\u5e94\u5bf9\u6bd2\u6027\u53cd\u5e94\u8fdb\u884c\u5bc6\u5207\u76d1\u6d4b\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u787c\u66ff\u4f50\u7c73\u76ae\u4e0b\u6ce8\u5c04\u5177\u6709\u4e0e\u9759\u8109\u63a8\u6ce8\u540c\u6837\u7684\u7597\u6548\uff0c\u4e14\u795e\u7ecf\u75c5\u53d8\u53d1\u751f\u7387\u66f4\u4f4e\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u9700\u8981\u5177\u6709\u6cbb\u7597\u6307\u5f81\uff0c\u5373\u4ee5\u4e0b\u5176\u4e2d\u4e4b\u4e00\uff1a\u80be\u529f\u80fd\u5f02\u5e38\u3001\u8840\u9499\u5347\u9ad8\u3001\u8d2b\u8840\u53ca\u9aa8\u8d28\u7834\u574f\u3001\u8840\u6e05\u6e38\u79bb\u8f7b\u94fe\u6bd4\u503c\u5927\u4e8e<span>100<\/span>\u3001\u9aa8\u9ad3\u4e2d\u514b\u9686\u6d46\u7ec6\u80de\u5927\u4e8e<span>60%<\/span>\u3001\u6838\u78c1\u8bc1\u5b9e<span>2<\/span>\u5904\u6216\u4ee5\u4e0a\u9aa8\u8d28\u7834\u574f\u624d\u9700\u8981\u6cbb\u7597\u3002\u4e0d\u7b26\u5408\u4ee5\u4e0a\u6807\u51c6\u7684\u5192\u70df\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u76ee\u524d\u4e0d\u5efa\u8bae\u8fdb\u884c\u6cbb\u7597\uff0c\u5305\u62ec\u787c\u66ff\u4f50\u7c73\u7684\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u787c\u66ff\u4f50\u7c73\u5e94\u7528\u4e8e\u521d\u6cbb\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08<span>FDA<\/span>\u5df2\u83b7\u6279\uff0c\u57fa\u4e8e<span>LYM-3002<\/span>\u7814\u7a76\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08<span>FDA<\/span>\u5df2\u6279\u51c6\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">12.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5176\u4ed6\u7f55\u89c1\u6d46\u7ec6\u80de\u75c5\uff0c\u5982\u8f7b\u94fe\u6dc0\u7c89\u6837\u53d8\u6027\u3001<span>POEMS<\/span>\uff08\u4ec5\u2160\uff5e\u2161\u671f\u6570\u636e\uff09\u3001<span>MGRS<\/span>\uff08\u610f\u4e49\u672a\u660e\u5355\u514b\u9686\u514d\u75ab\u7403\u86cb\u767d\u8840\u75c7\u4f34\u80be\u810f\u635f\u4f24\uff0c\u4ec5\u6709\u2160\uff5e\u2161\u671f\u6570\u636e\uff09\u7b49\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5341\u4e8c\u3001\u4fe1\u8fea\u5229\u5355\u6297<span> Sintilimab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u9002\u7528\u4e8e\u81f3\u5c11\u7ecf\u8fc7\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u8bca\u65ad\u4e3a\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5e94\u8be5\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\u8bc4\u4f30\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u53cd\u5e94\u53ca\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u91c7\u7528\u9759\u8109\u8f93\u6ce8\u7684\u65b9\u5f0f\u7ed9\u836f\uff0c\u9759\u8109\u8f93\u6ce8\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>200mg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5982\u51fa\u73b0\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\u3002\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<b><span><\/span><\/b><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u672c\u54c1\u5c1a\u65e0\u9488\u5bf9\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\uff1b\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u672c\u54c1\u5c1a\u65e0\u9488\u5bf9\u4e2d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u8f7b\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\uff1b\u4e2d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u7684\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u2265<span>10%<\/span>\uff09\u5305\u62ec\u53d1\u70ed\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u75c7\u3001\u4f53\u91cd\u589e\u52a0\u3001\u80ba\u708e\u3001\u4e0a\u547c\u5438\u9053\u611f\u67d3\u3001\u76ae\u75b9\u3001\u8d2b\u8840\u3001\u54b3\u55fd\u3002\u6700\u5e38\u89c1\u7684<span>3<\/span>\u7ea7\u4ee5\u4e0a\u7684\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u4f53\u91cd\u589e\u52a0\u3001\u8d2b\u8840\u3001\u8f93\u6db2\u53cd\u5e94\u3001\u547c\u5438\u9053\u611f\u67d3\u3001\u611f\u67d3\u6027\u80ba\u708e\u3001\u514d\u75ab\u76f8\u5173\u6027\u80ba\u708e\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5c1a\u65e0<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u53ca\u9752\u5c11\u5e74\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5728\u2265<span>65<\/span>\u5c81\u7684\u8001\u5e74\u60a3\u8005\u4e2d\u5e94\u7528\u6570\u636e\u6709\u9650\uff0c\u5efa\u8bae\u5728\u533b\u751f\u7684\u6307\u5bfc\u4e0b\u614e\u7528\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e0d\u5efa\u8bae\u5728\u598a\u5a20\u671f\u95f4\u4f7f\u7528\u672c\u54c1\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">12.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u56e0\u53ef\u80fd\u5e72\u6270\u672c\u54c1\u836f\u6548\u5b66\u6d3b\u6027\uff0c\u5e94\u907f\u514d\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002\u4f46\u662f\u5982\u679c\u4e3a\u4e86\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u540e\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e09\u3001\u5361\u745e\u5229\u73e0\u5355\u6297<span> Camrelizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7c89\u9488\u5242\uff1a<span>200mg\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u9002\u7528\u4e8e\u81f3\u5c11\u7ecf\u8fc7\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u660e\u786e\u8bca\u65ad\u4e3a\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u8be5\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\u8bc4\u4f30\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u53cd\u5e94\u53ca\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u91c7\u7528\u9759\u8109\u8f93\u6ce8\u7684\u65b9\u5f0f\u7ed9\u836f\uff0c\u9759\u8109\u8f93\u6ce8\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>200mg<\/span>\uff0c\u6bcf<span>2<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u51fa\u73b0\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\u3002\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u672c\u54c1\u5c1a\u65e0\u9488\u5bf9\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u672c\u54c1\u5c1a\u65e0\u9488\u5bf9\u4e2d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u4e2d\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002\u8f7b\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a5\u53d7\u672c\u836f\u6cbb\u7597\u7684\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u2265<span>10%<\/span>\uff09\u5305\u62ec\u76ae\u80a4\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u3001\u53d1\u70ed\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u3001\u4e0a\u547c\u5438\u9053\u611f\u67d3\u3001\u8d2b\u8840\u3001\u8f93\u6db2\u76f8\u5173\u53cd\u5e94\u3001\u54b3\u55fd\u3001\u53e3\u8154\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u3001\u9f3b\u54bd\u708e\u3001\u7619\u75d2\u75c7\u3002\u6700\u5e38\u89c1\u7684<span>3<\/span>\u7ea7\u4ee5\u4e0a\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u2265<span>2%<\/span>\uff09\u5305\u62ec\u6dcb\u5df4\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u3001\u767d\u7ec6\u80de\u8ba1\u6570\u51cf\u5c11\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u3001\u03b3<span>&#8211;<\/span>\u8c37\u6c28\u9170\u8f6c\u79fb\u9176\u5347\u9ad8\u3001\u5e26\u72b6\u75b1\u75b9\u3001\u80ba\u90e8\u708e\u75c7\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5c1a\u65e0<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u53ca\u9752\u5c11\u5e74\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5728\u2265<span>65<\/span>\u5c81\u7684\u8001\u5e74\u60a3\u8005\u4e2d\u5e94\u7528\u6570\u636e\u6709\u9650\uff0c\u5efa\u8bae\u5728\u533b\u751f\u7684\u6307\u5bfc\u4e0b\u614e\u7528\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u5efa\u8bae\u5728\u598a\u5a20\u671f\u95f4\u4f7f\u7528\u672c\u54c1\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">12.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56e0\u53ef\u80fd\u5e72\u6270\u672c\u54c1\u836f\u6548\u5b66\u6d3b\u6027\uff0c\u5e94\u907f\u514d\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002\u4f46\u662f\u5982\u679c\u4e3a\u4e86\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u540e\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">13.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u7684\u5904\u7406\uff1a\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u53ef\u6709\u7ea6<span>70%<\/span>\u53d1\u751f\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u3002\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\uff0c\u5927\u591a\u53d1\u751f\u5728\u4f53\u8868\u76ae\u80a4\uff0c\u5c11\u6570\u53ef\u89c1\u4e8e\u53e3\u8154\u9ecf\u819c\u3001\u9f3b\u8154\u9ecf\u819c\u4ee5\u53ca\u773c\u7751\u7ed3\u819c\u3002\u53d1\u751f\u4e8e\u76ae\u80a4\u7684\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\uff0c\u521d\u59cb\u591a\u8868\u73b0\u4e3a\u4f53\u8868\u9c9c\u7ea2\u8272\u70b9\u72b6\u7269\uff0c\u76f4\u5f84\u2264<span>2mm<\/span>\uff0c\u968f\u7740\u7528\u836f\u6b21\u6570\u589e\u52a0\uff0c\u75c5\u53d8\u8303\u56f4\u53ef\u9010\u6e10\u589e\u5927\uff0c\u591a\u4e3a\u7ed3\u8282\u72b6\uff0c\u4e5f\u6709\u6591\u7247\u72b6\uff0c\u989c\u8272\u9c9c\u7ea2\u6216\u6697\u7ea2\uff0c\u9700\u89c2\u5bdf\u4e34\u5e8a\u75c7\u72b6\u548c\u4f53\u5f81\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5f53\u60a3\u8005\u51fa\u73b0\u8be5\u4e0d\u826f\u53cd\u5e94\u65f6\uff0c\u5e94\u907f\u514d\u6293\u6320\u6216\u6469\u64e6\uff0c\u6613\u6469\u64e6\u90e8\u4f4d\u53ef\u7528\u7eb1\u5e03\u4fdd\u62a4\u4ee5\u907f\u514d\u51fa\u8840\uff0c\u540c\u65f6\u5e94\u8054\u7cfb\u4e3b\u7ba1\u533b\u751f\uff0c\u83b7\u5f97\u6070\u5f53\u7684\u5904\u7406\u5efa\u8bae\u3002\u7834\u6e83\u51fa\u8840\u8005\u53ef\u91c7\u7528\u5c40\u90e8\u538b\u8feb\u6b62\u8840\uff0c\u6216\u91c7\u53d6\u5982\u6fc0\u5149\u6216\u624b\u672f\u5207\u9664\u7b49\u5c40\u90e8\u6cbb\u7597\uff1b\u5e76\u53d1\u611f\u67d3\u8005\u5e94\u7ed9\u4e88\u6297\u611f\u67d3\u6cbb\u7597\u3002\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u53ef\u80fd\u5728\u76ae\u80a4\u4ee5\u5916\u7684\u5176\u4ed6\u7ec4\u7ec7\u53d1\u751f\uff08\u5305\u62ec\u5185\u810f\u5668\u5b98\uff09\uff0c\u5fc5\u8981\u65f6\u8fdb\u884c\u76f8\u5e94\u7684\u533b\u5b66\u68c0\u67e5\uff0c\u5982\u5927\u4fbf\u6f5c\u8840\u3001\u5185\u7aa5\u955c\u53ca\u5f71\u50cf\u5b66\u68c0\u67e5\uff08\u5177\u4f53\u76f8\u5173\u5185\u5bb9\u8be6\u89c1\u300a\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u4fe1\u606f\u6536\u96c6\u53ca\u98ce\u9669\u7ba1\u7406\u8ba1\u5212\u300b\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u56db\u3001\u66ff\u96f7\u5229\u73e0\u5355\u6297<span>Tislelizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u81f3\u5c11\u7ecf\u8fc7\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u8be5\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\u8bc4\u4f30\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u53cd\u5e94\u53ca\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u91c7\u7528\u9759\u8109\u8f93\u6ce8\u7684\u65b9\u5f0f\u7ed9\u836f\uff0c\u9759\u8109\u8f93\u6ce8\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>200mg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\uff0c\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\u3002\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u5c1a\u65e0\u9488\u5bf9\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u5c1a\u65e0\u9488\u5bf9\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u614e\u7528\u672c\u54c1\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u54fa\u4e73\u671f\u5987\u5973\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u53ca\u672b\u6b21\u7ed9\u836f\u540e\u81f3\u5c11<span>5<\/span>\u4e2a\u6708\u5185\u505c\u6b62\u54fa\u4e73\u3002\u80b2\u9f84\u671f\u5987\u5973\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u671f\u95f4\uff0c\u4ee5\u53ca\u6700\u540e\u4e00\u6b21\u672c\u54c1\u7ed9\u836f\u540e\u81f3\u5c11<span>5<\/span>\u4e2a\u6708\u5185\u5e94\u91c7\u7528\u6709\u6548\u907f\u5b55\u63aa\u65bd\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56e0\u53ef\u80fd\u5e72\u6270\u672c\u54c1\u836f\u6548\u5b66\u6d3b\u6027\uff0c\u5e94\u907f\u514d\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002\u4f46\u662f\u5982\u679c\u4e3a\u4e86\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u540e\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5176\u4ed6\uff1a\u5355\u836f\u6cbb\u7597\u590d\u53d1\u96be\u6cbb\u7ed3\u5916<span>NK\/T<\/span>\u7ec6\u80de\u6dcb\u5df4\u7624\uff08\u4ec5\u6709\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff09\u3002\u5355\u836f\u6cbb\u7597\u590d\u53d1\u96be\u6cbb\u5916\u5468<span>T<\/span>\u7ec6\u80de\u6dcb\u5df4\u7624\uff08\u4ec5\u6709\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e94\u3001\u6cfd\u5e03\u66ff\u5c3c <span>Zanubrutinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>80mg<\/span><\/span><b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u4eba\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08<span>MCL<\/span>\uff09\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u4eba\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08<span>CLL<\/span>\uff09<span>\/<\/span>\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08<span>SLL<\/span>\uff09\u60a3\u8005\u3002<\/span><b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cfd\u5e03\u66ff\u5c3c\u7528\u4e8e<span>CLL<\/span>\u6cbb\u7597\u524d\uff0c\u5e94\u8fdb\u884c\u4e25\u683c\u4e34\u5e8a\u8bc4\u4f30\uff0c\u5982\u679c\u60a3\u8005\u6709\u660e\u786e<span>del<\/span>\uff08<span>17p<\/span>\uff09\uff0c\u9009<span>BTK<\/span>\u6291\u5236\u5242\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u8be5\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\u8bc4\u4f30\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u53cd\u5e94\u53ca\u6bd2\u6027\uff0c\u6ce8\u610f\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\uff08\u5c24\u5176\u5728<span>CLL<\/span>\u60a3\u8005\u4e2d\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597<span>MCL<\/span>\u4e0e<span>CLL\/SLL<\/span>\u7684\u63a8\u8350\u5242\u91cf\u5747\u4e3a<span>160mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff08<span>Child-Pugh A<\/span>\u7ea7\u548c<span>B<\/span>\u7ea7\uff09\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff08<span>Child-Pugh B<\/span>\u7ea7\u548c<span>C<\/span>\u7ea7\uff09\u7684\u63a8\u8350\u5242\u91cf\u662f<span>80mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53e3\u670d\u7ed9\u836f\uff0c\u6bcf\u5929\u7684\u7528\u836f\u65f6\u95f4\u5927\u81f4\u56fa\u5b9a\u3002\u5e94\u7528\u6c34\u9001\u670d\u6574\u7c92\u80f6\u56ca\uff0c\u53ef\u5728\u996d\u524d\u6216\u996d\u540e\u670d\u7528\u3002\u7981\u6b62\u6253\u5f00\u3001\u5f04\u7834\u6216\u5480\u56bc\u80f6\u56ca\u3002\u5982\u679c\u672a\u5728\u8ba1\u5212\u65f6\u95f4\u670d\u7528\u672c\u54c1\uff0c\u60a3\u8005\u5e94\u5728\u76f8\u90bb\u670d\u836f\u95f4\u9694\u81f3\u5c11<span>8<\/span>\u5c0f\u65f6\u57fa\u7840\u4e0a\u5c3d\u5feb\u670d\u7528\uff0c\u5e76\u5728\u540e\u7eed\u6062\u590d\u6b63\u5e38\u7528\u836f\u8ba1\u5212\u3002\u8bf7\u52ff\u989d\u5916\u670d\u7528\u672c\u54c1\u4ee5\u5f25\u8865\u6f0f\u670d\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7c92\u7ec6\u80de\u51cf\u5c11\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u3001\u8d2b\u8840\u662f\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u3002\u7528\u836f\u671f\u95f4\u9700\u8981\u76d1\u6d4b\u8840\u5e38\u89c4\u3002\u51fa\u73b0<span>3<\/span>\u7ea7\u8840\u6db2\u5b66\u6bd2\u6027\u53ca\u4ee5\u4e0a\u6ce8\u610f\u5242\u91cf\u8c03\u6574\u3002<span>\u22653<\/span>\u7ea7\u4f34\u611f\u67d3\u6216\u53d1\u70ed\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u6216\u8005<span>4<\/span>\u7ea7\u8840\u6db2\u5b66\u6bd2\u6027\u65f6\uff0c\u5e94\u4e2d\u65ad\u6cbb\u7597\uff0c\u5f85\u6bd2\u6027\u75c7\u72b6\u6d88\u9000\u81f3<span>1<\/span>\u7ea7\u6216\u57fa\u7ebf\u6c34\u5e73\uff08\u6062\u590d\uff09\u65f6\uff0c\u53ef\u4ee5\u8d77\u59cb\u5242\u91cf\u91cd\u65b0\u5f00\u59cb\u6cbb\u7597\u3002\u5982\u679c\u8be5\u6bd2\u6027\u518d\u6b21\u53d1\u751f\uff0c\u5e94\u518d\u6b21\u4e2d\u65ad\u6cbb\u7597\uff0c\u5f85\u6bd2\u6027\u75c7\u72b6\u6d88\u9000\u81f3<span>1<\/span>\u7ea7\u6216\u57fa\u7ebf\u6c34\u5e73\uff08\u6062\u590d\uff09\u65f6\u4ee5<span>80mg<\/span><\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\/<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\u7684\u5242\u91cf\u91cd\u65b0\u5f00\u59cb\u7528\u836f\u3002\u5982\u679c\u5728\u5242\u91cf\u964d\u4f4e\u540e\u8be5\u6bd2\u6027\u7b2c\u4e09\u6b21\u53d1\u751f\uff0c\u5e94\u518d\u6b21\u4e2d\u65ad\u6cbb\u7597\uff0c\u5f85\u6bd2\u6027\u75c7\u72b6\u6d88\u9000\u81f3<span>1<\/span>\u7ea7\u6216\u57fa\u7ebf\u6c34\u5e73\uff08\u6062\u590d\uff09\u65f6\u4ee5<span>80mg<\/span><span>\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e00\u6b21\u7684\u5242\u91cf\u91cd\u65b0\u5f00\u59cb\u7528\u836f\u3002\u5982\u679c\u5728\u4e24\u6b21\u5242\u91cf\u964d\u4f4e\u540e\u8be5\u6bd2\u6027\u7b2c\u56db\u6b21\u53d1\u751f\uff0c\u5e94\u7ec8\u6b62\u672c\u54c1\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0e<span>CYP3A<\/span>\u6291\u5236\u5242\u6216\u8bf1\u5bfc\u5242\u8054\u5408\u7ed9\u836f\u65f6\u7684\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8868<span>4<\/span>&emsp;\u4e0e<span>CYP3A<\/span>\u6291\u5236\u5242\u6216\u8bf1\u5bfc\u5242\u8054\u5408\u7ed9\u836f\u65f6\u7684\u5242\u91cf\u8c03\u6574<span><\/span><\/span><\/b>\n<\/p>\n<table class=\"MsoNormalTable\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"1148\" style=\"width:430.65pt;border-collapse:collapse;border:none;\">\n<tbody>\n<tr>\n<td width=\"411\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8054\u5408\u7ed9\u836f<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"737\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u8c03\u6574\u5efa\u8bae<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"411\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5f3a\u6548<span>CYP3A<\/span>\u6291\u5236\u5242<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"737\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">80mg\/<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b21\uff0c\u6bcf\u5929\u4e00\u6b21<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51fa\u73b0\u4e0d\u826f\u53cd\u5e94\u65f6\u6839\u636e\u5242\u91cf\u8c03\u6574\u5efa\u8bae\u4e2d\u65ad\u7ed9\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"411\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e2d\u6548<span>CYP3A<\/span>\u6291\u5236\u5242<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"737\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">80mg\/<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51fa\u73b0\u4e0d\u826f\u53cd\u5e94\u65f6\u518d\u6b21\u5242\u91cf\u8c03\u6574<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"411\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5f3a\u6548\u6216\u4e2d\u6548<span>CYP3A<\/span>\u8bf1\u5bfc\u5242<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"737\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u540c\u65f6\u4f7f\u7528<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e59\u809d\u75c5\u6bd2\u518d\u6fc0\u6d3b\u7684\u98ce\u9669\uff1a\u4f7f\u7528\u6cfd\u5e03\u66ff\u5c3c\u8fc7\u7a0b\u4e2d\u9700\u8981\u6ce8\u610f\u4e59\u809d\u75c5\u6bd2\u6fc0\u6d3b\u7684\u98ce\u9669\u3002\u5e94\u5728\u4f7f\u7528\u524d\u660e\u786e\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u72b6\u6001\uff0c\u5bf9\u4e8e\u76ee\u524d\u6216\u65e2\u5f80\u6709\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u611f\u67d3\u7684\u60a3\u8005\uff0c\u5728\u5f00\u59cb\u6cbb\u7597\u524d\u9700\u8981\u54a8\u8be2\u809d\u708e\u4e13\u79d1\u533b\u5e08\uff0c\u5e76\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u6ce8\u610f\u76d1\u6d4b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u5efa\u8bae\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\uff08\u808c\u9150\u6e05\u9664\u7387\uff1c<span>30ml\/min<\/span>\uff09\u6216\u900f\u6790\u60a3\u8005\u4f7f\u7528\u672c\u54c1\u9700\u8981\u6ce8\u610f\u76d1\u6d4b\u4e0d\u826f\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5176\u4ed6\u9002\u5e94\u8bc1\uff1a\u4e00\u7ebf\u6cbb\u7597\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5<span>\/<\/span>\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08\u57fa\u4e8e\u5168\u7403\u591a\u4e2d\u5fc3\u2161\u671f\u4e34\u5e8a\u7814\u7a76<span>AU003<\/span>\u7684\u6570\u636e\uff0c\u4ee5\u53ca\u5168\u7403\u591a\u4e2d\u5fc3\u2162\u671f\u4e34\u5e8a\u7814\u7a76<span>SEQUOIA<\/span>\u7814\u7a76\u4e2d<span>17p-<\/span>\u4e9a\u7ec4\u7684\u6570\u636e\uff09\uff0c\u521d\u6cbb\u53ca\u590d\u53d1\u7684\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\u6dcb\u5df4\u7624\uff08\u2162\u671f\u4e34\u5e8a\u7814\u7a76\uff09\u3002\u590d\u53d1<span>\/<\/span>\u96be\u6cbb\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624\uff08\u4ec5\u6709\u2160\uff5e\u2161\u671f\u4e34\u5e8a\u7814\u7a76\uff09\uff0c\u590d\u53d1<span>\/<\/span>\u96be\u6cbb\u6ee4\u6ce1\u578b\u6dcb\u5df4\u7624\uff08\u4ec5\u6709\u2160\uff5e\u2161\u671f\u4e34\u5e8a\u7814\u7a76\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u516d\u3001\u6765\u90a3\u5ea6\u80fa<span> Lenalidomide<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10mg<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u3001<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">25mg<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u521d\u6cbb\u53ca\u590d\u53d1\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3002<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u836f\u7269\u5177\u6709\u9aa8\u9ad3\u6291\u5236\u4f5c\u7528\uff0c\u5e94\u7528\u540e\u9700\u8981\u76d1\u6d4b\u60a3\u8005\u8840\u5e38\u89c4\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u9002\u5408\u63a5\u6536\u81ea\u4f53\u5e72\u7ec6\u80de\u79fb\u690d\u7684\u75c5\u4eba\uff0c\u79fb\u690d\u524d\u5efa\u8bae\u63a5\u53d7\u4e0d\u8981\u8d85\u8fc7<span>4<\/span>\u4e2a\u7597\u7a0b\u542b\u6709\u6765\u90a3\u5ea6\u80fa\u7684\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u787c\u66ff\u4f50\u7c73\u4e0e\u6765\u90a3\u5ea6\u80fa\u5177\u6709\u534f\u540c\u4f5c\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80be\u529f\u80fd\u635f\u4f24\u7684\u9aa8\u9ad3\u7624\u60a3\u8005\u9700\u8981\u51cf\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u957f\u671f\u5e94\u7528\u4f1a\u589e\u52a0\u7b2c\u4e8c\u80bf\u7624\u7684\u98ce\u9669\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8840\u7ec6\u80de\u51cf\u5c11\u3001\u76ae\u75b9\u4e3a\u6765\u90a3\u5ea6\u80fa\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5176\u4f59\u5305\u62ec\u6df1\u9759\u8109\u8840\u6813\u3002<b><span><\/span><\/b><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u63a5\u53d7\u6765\u90a3\u5ea6\u80fa\u4e0e\u5730\u585e\u7c73\u677e\u8054\u5408\u6cbb\u7597\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\uff0c\u6df1\u9759\u8109\u8840\u6813\u548c\u80ba\u6813\u585e\u7684\u98ce\u9669\u663e\u8457\u5347\u9ad8\u3002\u9700\u8981\u5bc6\u5207\u6ce8\u610f\u8840\u6813\u5bfc\u81f4\u7684\u75c7\u72b6\u548c\u4f53\u5f81\uff0c\u5408\u5e76\u9ad8\u5371\u8840\u6813\u98ce\u9669\u65f6\u5efa\u8bae\u7ed9\u4e88\u9884\u9632\u6027\u6297\u51dd\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53ef\u80fd\u4f1a\u6709\u80da\u80ce<span>&#8211;<\/span>\u751f\u6b96\u6bd2\u6027\uff0c\u4f7f\u7528\u671f\u95f4\u6ce8\u610f\u907f\u5b55\u3002\u5bf9\u513f\u7ae5\u751f\u957f\u53d1\u80b2\u4f1a\u6709\u6f5c\u5728\u5f71\u54cd\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ee4\u6ce1\u7ec6\u80de\u6dcb\u5df4\u7624\uff08\u5168\u7403\u5176\u4ed6\u56fd\u5bb6\u5df2\u6279\u51c6\u7684\u9002\u5e94\u8bc1\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.POEMS<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7efc\u5408\u5f81\uff08\u4ec5\u6709\u2160\uff5e\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u94fe\u6dc0\u7c89\u6837\u53d8\u6027\uff08\u4ec5\u6709\u2160\uff5e\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">12.MGRS<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08\u4ec5\u6709\u2160\uff5e\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">13.del<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08<span>5q<\/span>\uff09\u7684<span>IPSS<\/span>\u8bc4\u5206\u4f4e\u5371<span>\/<\/span>\u4e2d\u5371<span>1<\/span>\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\uff08\u5168\u7403\u5176\u4ed6\u56fd\u5bb6\u5df2\u6279\u51c6\u7684\u9002\u5e94\u8bc1\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e03\u3001\u6cca\u9a6c\u5ea6\u80fa<span> Pomalidomide<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>1mg<\/span>\u3001<span>4mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u590d\u53d1\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff1a\u6cca\u9a6c\u5ea6\u80fa\u4e0e\u5730\u585e\u7c73\u677e\u8054\u7528\uff0c\u9002\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e24\u79cd\u6cbb\u7597\uff08\u5305\u62ec\u6765\u90a3\u5ea6\u80fa\u548c\u4e00\u79cd\u86cb\u767d\u9176\u4f53\u6291\u5236\u5242\uff09\uff0c\u4e14\u5728\u6700\u540e\u4e00\u6b21\u6cbb\u7597\u671f\u95f4\u6216\u6cbb\u7597\u7ed3\u675f\u540e<span>60<\/span>\u5929\u5185\u53d1\u751f\u75be\u75c5\u8fdb\u5c55\u7684\u6210\u5e74\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u836f\u7269\u5177\u6709\u9aa8\u9ad3\u6291\u5236\u4f5c\u7528\uff0c\u5e94\u7528\u540e\u9700\u8981\u76d1\u6d4b\u60a3\u8005\u8840\u5e38\u89c4\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u9002\u5408\u63a5\u53d7\u81ea\u4f53\u5e72\u7ec6\u80de\u79fb\u690d\u7684\u75c5\u4eba\uff0c\u79fb\u690d\u524d\u5efa\u8bae\u63a5\u53d7\u4e0d\u8981\u8d85\u8fc7<span>4<\/span>\u4e2a\u7597\u7a0b\u542b\u6709\u6cca\u9a6c\u5ea6\u80fa\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u787c\u66ff\u4f50\u7c73\u4e0e\u6cca\u9a6c\u5ea6\u80fa\u5177\u6709\u534f\u540c\u4f5c\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u9700\u8981\u900f\u6790\u7684\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u63a8\u8350\u7684\u8d77\u59cb\u5242\u91cf\u662f<span>3mg\/d<\/span>\uff08\u964d\u4f4e<span>25%<\/span>\uff09\u3002\u5728\u63a5\u53d7\u8840\u6db2\u900f\u6790\u7684\u5f53\u5929\uff0c\u5e94\u5728\u5b8c\u6210\u900f\u6790\u4e4b\u540e\u670d\u7528\u6cca\u9a6c\u5ea6\u80fa\u3002\u5176\u4ed6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u8f7b\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff08<span>Child-Pugh A<\/span>\u7ea7\u6216<span>B<\/span>\u7ea7\uff09\uff0c\u63a8\u8350\u8d77\u59cb\u5242\u91cf\u662f<span>3mg\/d<\/span>\uff08\u964d\u4f4e<span>25%<\/span>\uff09\u3002\u5bf9\u4e8e\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff08<span>Child-Pugh C<\/span>\u7ea7\uff09\uff0c\u63a8\u8350\u7ed9\u836f\u5242\u91cf\u662f<span>2mg<\/span>\uff08\u964d\u4f4e<span>50%<\/span>\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cca\u9a6c\u5ea6\u80fa\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\uff08\uff1e<span>30%<\/span>\uff09\u5305\u62ec\u75b2\u52b3\u4e4f\u529b\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u8d2b\u8840\u3001\u4fbf\u79d8\u3001\u6076\u5fc3\u3001\u8179\u6cfb\u3001\u547c\u5438\u56f0\u96be\u3001\u4e0a\u547c\u5438\u9053\u611f\u67d3\u3001\u80cc\u75db\u548c\u53d1\u70ed\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u63a5\u53d7\u6cca\u9a6c\u5ea6\u80fa\u6cbb\u7597\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\uff0c\u6cbb\u7597\u671f\u95f4\u6709\u53d1\u751f\u6df1\u9759\u8109\u8840\u6813\u548c\u80ba\u6813\u585e\u7684\u98ce\u9669\u3002\u5bf9\u4e8e\u6709\u5df2\u77e5\u98ce\u9669\u56e0\u7d20\uff08\u5305\u62ec\u8840\u6813\u53f2\uff09\u7684\u75c5\u4eba\uff0c\u53d1\u751f\u9759\u8109\u548c\u52a8\u8109\u8840\u6813\u6813\u585e\u4e8b\u4ef6\u7684\u98ce\u9669\u66f4\u9ad8\u3002\u63a8\u8350\u8fdb\u884c\u8840\u6813\u7684\u9884\u9632\u6cbb\u7597\uff0c\u5e94\u57fa\u4e8e\u5bf9\u60a3\u8005\u6f5c\u5728\u98ce\u9669\u56e0\u7d20\u7684\u8bc4\u4f30\u9009\u62e9\u6cbb\u7597\u65b9\u6848\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53ef\u80fd\u4f1a\u6709\u80da\u80ce<span>&#8211;<\/span>\u751f\u6b96\u6bd2\u6027\uff0c\u4f7f\u7528\u671f\u95f4\u987b\u6ce8\u610f\u907f\u5b55\uff0c\u65e0\u8bba\u7537\u5973\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0e\u5f3a\u6548<span> CYP1A2 <\/span>\u6291\u5236\u5242\u8054\u7528\uff08\u73af\u4e19\u6c99\u661f\u3001\u6c1f\u4f0f\u6c99\u660e\uff09\uff0c\u8003\u8651\u5176\u4ed6\u66ff\u4ee3\u7597\u6cd5\u3002\u5982\u65e0\u6cd5\u907f\u514d\u4e0e\u5f3a\u6548<span>CYP1A2 <\/span>\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\uff0c\u5219\u8d77\u59cb\u5242\u91cf\u5e94\u51cf\u5c11\u81f3<span>2mg<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5361\u6ce2\u897f\u8089\u7624\uff08\u7f8e\u56fd\u5df2\u6279\u51c6\u7684\u9002\u5e94\u8bc1\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cca\u9a6c\u5ea6\u80fa\u8054\u5408\u787c\u66ff\u4f50\u7c73\u4ee5\u53ca\u5730\u585e\u7c73\u677e\u6cbb\u7597\u590d\u53d1\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff1a\u6cca\u9a6c\u5ea6\u80fa\u4e0e\u787c\u66ff\u4f50\u7c73\u3001\u5730\u585e\u7c73\u677e\u8054\u7528\uff0c\u9002\u7528\u4e8e\u65e2\u5f80\u5df2\u63a5\u53d7\u81f3\u5c11\u4e00\u79cd\u6cbb\u7597\u65b9\u6848\uff08\u5305\u62ec\u6765\u90a3\u5ea6\u80fa\uff09\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u6210\u4eba\u60a3\u8005\uff08\u6b27\u6d32\u5df2\u6279\u51c6\u7684\u9002\u5e94\u8bc1\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">12.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u94fe\u6dc0\u7c89\u6837\u53d8\u6027\uff1a\u6709\u2160\uff5e\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff0c\u5e76\u88ab\u8f7b\u94fe\u6dc0\u7c89\u6837\u53d8\u6027<span>2021V2<\/span>\u7248<span>NCCN<\/span>\u6307\u5357\u63a8\u8350\uff08<span>2A<\/span>\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">13.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u539f\u53d1\u6027\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u6dcb\u5df4\u7624\uff1a\u6709\u2160\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff0c\u5e76\u88ab\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u6dcb\u5df4\u7624<span>2021V1<\/span>\u7248<span>NCCN<\/span>\u6307\u5357\u63a8\u8350\uff08<span>2A<\/span>\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u516b\u3001\u6c99\u5229\u5ea6\u80fa<span> Thalidomide<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08<span>1<\/span>\uff09\u7247\u5242\uff1a<span>25mg<\/span>\uff1b\uff08<span>2<\/span>\uff09\u80f6\u56ca\uff1a<span>25mg<\/span><\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7624\u578b\u9ebb\u98ce\u75c5\u3002<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c99\u5229\u5ea6\u80fa\u53ef\u4ee5\u5f15\u8d77\u5fc3\u7387\u51cf\u6162\uff0c\u4e25\u91cd\u8005\u51fa\u73b0\u4e09\u5ea6\u623f\u5ba4\u4f20\u5bfc\u963b\u6ede\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u672c\u54c1\u6709\u8fc7\u654f\u53cd\u5e94\u7684\u60a3\u8005\u614e\u7528\u3002\u6c99\u5229\u5ea6\u80fa\u5177\u6709\u81f4\u7578\u6027\uff0c\u5b55\u5987\u53ca\u54fa\u4e73\u671f\u5987\u5973\u3001\u513f\u7ae5\u7981\u7528\u3002\u5176\u4ed6\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u5fc3\u7387\u51cf\u6162\u3001\u76ae\u75b9\u3001\u4fbf\u79d8\u3001\u5468\u56f4\u795e\u7ecf\u75c5\u53d8\u3001\u55dc\u7761\u53ca\u6df1\u9759\u8109\u8840\u6813\u7b49\uff0c\u53ef\u901a\u8fc7\u51cf\u91cf\u4ee5\u53ca\u8f85\u52a9\u7528\u836f\u7f13\u89e3\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u787c\u66ff\u4f50\u7c73\u4e0e\u6c99\u5229\u5ea6\u80fa\u5177\u6709\u534f\u540c\u4f5c\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u63a5\u53d7\u6c99\u5229\u5ea6\u80fa\u4e0e\u5730\u585e\u7c73\u677e\u8054\u5408\u6cbb\u7597\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\uff0c\u6df1\u9759\u8109\u8840\u6813\u548c\u80ba\u6813\u585e\u7684\u98ce\u9669\u663e\u8457\u5347\u9ad8\u3002\u9700\u8981\u5bc6\u5207\u6ce8\u610f\u8840\u6813\u5bfc\u81f4\u7684\u75c7\u72b6\u548c\u4f53\u5f81\uff0c\u5408\u5e76\u9ad8\u5371\u8840\u6813\u98ce\u9669\u65f6\u5efa\u8bae\u7ed9\u4e88\u9884\u9632\u6027\u6297\u51dd\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ec6\u80de\u9057\u4f20\u5b66\u9ad8\u5371\u60a3\u8005\u4e0d\u5efa\u8bae\u5355\u72ec\u4f7f\u7528\u6c99\u5229\u5ea6\u80fa\u8fdb\u884c\u7ef4\u6301\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u670d\u7528\u540e\u4f1a\u51fa\u73b0\u55dc\u7761\uff0c\u7729\u6655\uff0c\u4e0d\u5efa\u8bae\u5f00\u8f66\uff0c\u5e94\u4e34\u7761\u524d\u670d\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c99\u5229\u5ea6\u80fa\u53ef\u4ee5\u7528\u4e8e\u521d\u6cbb\u53ca\u96be\u6cbb\u590d\u53d1\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u75c5\u4eba\uff08\u5728\u56fd\u5916\u5927\u591a\u6570\u56fd\u5bb6\u90fd\u5df2\u7ecf\u6279\u51c6\u7528\u4e8e\u521d\u6cbb\u4ee5\u53ca\u96be\u6cbb\u590d\u53d1\u9aa8\u9ad3\u7624\u6cbb\u7597\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5341\u4e5d\u3001\u4f0a\u6c99\u4f50\u7c73<span> Ixazomib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>2.3mg<\/span>\u3001<span>3mg<\/span>\u3001<span>4mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e0e\u6765\u90a3\u5ea6\u80fa\u548c\u5730\u585e\u7c73\u677e\u8054\u7528\uff0c\u6cbb\u7597\u5df2\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u79cd\u65e2\u5f80\u6cbb\u7597\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u6210\u4eba\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u7684\u7ed9\u836f\u9014\u5f84\u4e3a\u53e3\u670d\u3002\u60a3\u8005\u5e94\u8be5\u5728\u6bcf\u4e2a\u6cbb\u7597\u5468\u671f\u7b2c<span>1<\/span>\u3001<span>8<\/span>\u548c<span>15<\/span>\u5929\u5927\u81f4\u76f8\u540c\u7684\u65f6\u95f4\u670d\u836f\uff0c\u5728\u8fdb\u9910\u524d\u81f3\u5c11<span>1<\/span>\u5c0f\u65f6\u6216\u8fdb\u9910\u540e\u81f3\u5c11<span>2<\/span>\u5c0f\u65f6\u670d\u7528\u672c\u54c1\uff0c\u5e94\u7528\u6c34\u9001\u670d\u6574\u7c92\u80f6\u56ca\u3002\u8bf7\u52ff\u538b\u788e\u3001\u5480\u56bc\u6216\u6253\u5f00\u80f6\u56ca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5728\u5f00\u59cb\u4e00\u4e2a\u65b0\u7684\u6cbb\u7597\u5468\u671f\u524d\u5e94\u6ee1\u8db3\uff1a\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u8ba1\u6570\u5e94\u2265<span>1<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u3001\u8840\u5c0f\u677f\u8ba1\u6570\u5e94\u2265<span>75<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff0c\u975e\u8840\u6db2\u5b66\u6bd2\u6027\u4e00\u822c\u5e94\u6062\u590d\u81f3\u60a3\u8005\u7684\u57fa\u7ebf\u72b6\u51b5\u6216\u2264<span>1<\/span>\u7ea7\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u5e94\u6301\u7eed\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u7531\u4e8e<span>24<\/span>\u4e2a\u5468\u671f\u4e4b\u540e\u7684\u8010\u53d7\u6027\u548c\u6bd2\u6027\u76f8\u5173\u6570\u636e\u6709\u9650\uff0c\u56e0\u6b64\u5bf9\u4e8e\u9700\u8981\u957f\u4e8e<span>24<\/span>\u4e2a\u5468\u671f\u7684\u8054\u5408\u7ed9\u836f\u6cbb\u7597\uff0c\u5e94\u57fa\u4e8e\u60a3\u8005\u4e2a\u4f53\u83b7\u76ca\u98ce\u9669\u8bc4\u4f30\u7ed3\u679c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5982\u679c\u5ef6\u8bef\u6216\u6f0f\u670d\u4e00\u5242\u672c\u54c1\uff0c\u53ea\u6709\u5f53\u8ddd\u79bb\u4e0b\u6b21\u8ba1\u5212\u7ed9\u836f\u65f6\u95f4\u2265<span>72<\/span>\u5c0f\u65f6\uff0c\u65b9\u53ef\u8865\u670d\u6f0f\u670d\u5242\u91cf\u3002\u8ddd\u79bb\u5728\u4e0b\u6b21\u8ba1\u5212\u7ed9\u836f\u7684<span>72<\/span>\u5c0f\u65f6\u5185\u4e0d\u5f97\u8865\u670d\u6f0f\u670d\u5242\u91cf\u3002\u4e0d\u5f97\u670d\u7528\u53cc\u500d\u5242\u91cf\u4ee5\u5f25\u8865\u6f0f\u670d\u7684\u5242\u91cf\u3002\u5982\u679c\u60a3\u8005\u5728\u670d\u836f\u540e\u5455\u5410\uff0c\u4e0d\u5e94\u91cd\u590d\u670d\u836f\uff0c\u800c\u5e94\u5728\u4e0b\u6b21\u8ba1\u5212\u7ed9\u836f\u65f6\u6062\u590d\u7ed9\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u5e94\u8003\u8651\u6297\u75c5\u6bd2\u836f\u7269\u7684\u9884\u9632\u6cbb\u7597\uff0c\u964d\u4f4e\u5e26\u72b6\u75b1\u75b9\u75c5\u6bd2\u518d\u6fc0\u6d3b\u7684\u98ce\u9669\u3002\u5728\u4f0a\u6c99\u4f50\u7c73\u7814\u7a76\u4e2d\uff0c\u63a5\u53d7\u6297\u75c5\u6bd2\u836f\u7269\u9884\u9632\u6cbb\u7597\u60a3\u8005\u7684\u5e26\u72b6\u75b1\u75b9\u611f\u67d3\u53d1\u751f\u7387\u4f4e\u4e8e\u672a\u63a5\u53d7\u9884\u9632\u6cbb\u7597\u7684\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u4f0a\u6c99\u4f50\u7c73\u548c\u6765\u90a3\u5ea6\u80fa\u8840\u5c0f\u677f\u51cf\u5c11\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u548c\u76ae\u75b9\u7684\u91cd\u53e0\u6bd2\u6027\uff0c\u5efa\u8bae\u4ea4\u66ff\u8c03\u6574\u4f0a\u6c99\u4f50\u7c73\u548c\u6765\u90a3\u5ea6\u80fa\u7684\u5242\u91cf\u3002\u5bf9\u4e8e\u8fd9\u4e9b\u6bd2\u6027\uff0c\u5242\u91cf\u8c03\u6574\u7684\u7b2c\u4e00\u6b65\u662f\u505c\u7528<span>\/<\/span>\u51cf\u4f4e\u6765\u90a3\u5ea6\u80fa\u5242\u91cf\uff0c\u5173\u4e8e\u8fd9\u4e9b\u6bd2\u6027\u7684\u5242\u91cf\u51cf\u4f4e\u6b65\u9aa4\uff0c\u53c2\u89c1\u6765\u90a3\u5ea6\u80fa\u836f\u54c1\u8bf4\u660e\u4e66\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff08\u603b\u80c6\u7ea2\u7d20\u2264<span>ULN<\/span>\u548c<span>AST<\/span>\uff1e<span>ULN<\/span>\uff0c\u6216\u603b\u80c6\u7ea2\u7d20\uff1e<span>1<\/span>\uff5e<span>1.5<\/span>\u500d<span>ULN<\/span>\u548c<span>AST<\/span>\u4efb\u4f55\u6c34\u5e73\uff09\uff0c\u65e0\u9700\u8c03\u6574\u672c\u54c1\u7684\u5242\u91cf\u3002\u5bf9\u4e8e\u4e2d\u5ea6\uff08\u603b\u80c6\u7ea2\u7d20\uff1e<span>1.5<\/span>\uff5e<span>3<\/span>\u500d<span>ULN<\/span>\uff09\u6216\u91cd\u5ea6\uff08\u603b\u80c6\u7ea2\u7d20\uff1e<span>3<\/span>\u500d<span>ULN<\/span>\uff09\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u5efa\u8bae\u51cf\u91cf\u81f3<span>3mg<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff08\u808c\u9150\u6e05\u9664\u7387\u2265<span>30ml\/min<\/span>\uff09\uff0c\u65e0\u9700\u8c03\u6574\u672c\u54c1\u7684\u5242\u91cf\u3002\u5bf9\u4e8e\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\uff08\u808c\u9150\u6e05\u9664\u7387\uff1c<span>30ml\/min<\/span>\uff09\u6216\u9700\u900f\u6790\u7684\u7ec8\u672b\u671f\u80be\u75c5\u60a3\u8005\uff0c\u5efa\u8bae\u51cf\u91cf\u81f3<span>3mg<\/span>\u3002\u4f0a\u6c99\u4f50\u7c73\u4e0d\u80fd\u901a\u8fc7\u900f\u6790\u6e05\u9664\uff0c\u56e0\u6b64\u7ed9\u836f\u65f6\u53ef\u4ee5\u65e0\u9700\u8003\u8651\u900f\u6790\u65f6\u95f4\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u5e74\u9f84\u5927\u4e8e<span>65<\/span>\u5c81\u7684\u60a3\u8005\uff0c\u65e0\u9700\u8c03\u6574\u672c\u54c1\u7684\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u6c99\u4f50\u7c73\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\uff08\uff1e<span>20%<\/span>\uff09\u5305\u62ec\u8179\u6cfb\u3001\u4fbf\u79d8\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u3001\u5468\u56f4\u795e\u7ecf\u75c5\u53d8\u3001\u6076\u5fc3\u3001\u5916\u5468\u6c34\u80bf\u3001\u5455\u5410\u548c\u80cc\u75db\u3002\u5468\u56f4\u795e\u7ecf\u75c5\u53d8\u53d1\u751f\u7387\u4f4e\u4e8e\u787c\u66ff\u4f50\u7c73\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4f0a\u6c99\u4f50\u7c73\u548c<span>CYP3A<\/span>\u5f3a\u6548\u6291\u5236\u5242\u3001<span>CYP1A2<\/span>\u5f3a\u6548\u6291\u5236\u5242\u8054\u5408\u7ed9\u836f\u9700\u8981\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">12.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5f53\u4f0a\u6c99\u4f50\u7c73\u4e0e\u5730\u585e\u7c73\u677e\u8054\u5408\u7ed9\u836f\u65f6\uff0c\u9700\u8003\u8651\u53e3\u670d\u907f\u5b55\u836f\u7597\u6548\u964d\u4f4e\u7684\u98ce\u9669\u3002\u4f7f\u7528\u6fc0\u7d20\u907f\u5b55\u7684\u5973\u6027\u8fd8\u9700\u91c7\u7528\u5c4f\u969c\u907f\u5b55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">13.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65b0\u8bca\u65ad\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3001\u6dc0\u7c89\u6837\u53d8\u6027\u3001\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08\u4ec5\u6709<span>I<\/span>\uff5e\u2161\u671f\u4e34\u5e8a\u6570\u636e\uff09\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u3001\u8fbe\u96f7\u59a5\u5c24\u5355\u6297<span> Daratumumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>5ml<\/span>\uff09<span>\/<\/span>\u74f6\u3001<span>400mg<\/span>\uff08<span>20ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5355\u836f\u6cbb\u7597\u590d\u53d1\u548c\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u6210\u5e74\u60a3\u8005\uff0c\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u8fc7\u5305\u62ec\u86cb\u767d\u9176\u4f53\u6291\u5236\u5242\u548c\u514d\u75ab\u8c03\u8282\u5242\u7684\u6cbb\u7597\u4e14\u6700\u540e\u4e00\u6b21\u6cbb\u7597\u65f6\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5373\u523b\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\u7684\u5904\u7406\uff1a\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u662f\u4e00\u79cd\u751f\u7269\u5236\u5242\uff0c\u4f5c\u4e3a\u4e00\u79cd\u5916\u6e90\u6027\u86cb\u767d\u4e0e\u5176\u4ed6\u9776\u5411\u6027\u5355\u6297\u4e00\u6837\uff0c\u6709\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\uff08<span>IRR<\/span>\uff09\u3002<span>IRR<\/span>\u4e3b\u8981\u8868\u73b0\u4e3a\u9f3b\u585e\u3001\u54b3\u55fd\u3001\u54bd\u5589\u90e8\u523a\u6fc0\u611f\u3001\u5bd2\u6218\u3001\u6076\u5fc3\u548c\u5455\u5410\uff0c\u4e25\u91cd\u7684<span>IRR<\/span>\u8868\u73b0\u4e3a\u652f\u6c14\u7ba1\u75c9\u631b\uff0c\u547c\u5438\u56f0\u96be\uff0c\u5589\u5934\u6c34\u80bf\uff0c\u80ba\u6c34\u80bf\u548c\u9ad8\u8840\u538b\u3002\u6ce8\u5c04\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u65f6\u5e94\u4e25\u683c\u9075\u5b88\u89c4\u5b9a\u7684\u8f93\u6ce8\u901f\u7387\u4ee5\u964d\u4f4e\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\u7684\u53d1\u751f\u98ce\u9669\u3002\u5bf9\u4e8e\u4efb\u4f55\u7b49\u7ea7<span>\/<\/span>\u4e25\u91cd\u7a0b\u5ea6\u7684<span>IRR<\/span>\uff0c\u5e94\u7acb\u5373\u4e2d\u65ad\u672c\u54c1\u8f93\u6ce8\u5e76\u5bf9\u75c7\u6cbb\u7597\u3002\u8fbe\u96f7\u59a5\u5c24\u5355\u6297<span>IRR<\/span>\u4e3b\u8981\u53d1\u751f\u5728\u9996\u6b21\u8f93\u6ce8\u540e\u7ea6\u4e3a<span>46%<\/span>\uff0c\u53d1\u751f<span>IRR<\/span>\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a<span>1.5<\/span>\u5c0f\u65f6\uff0c\u7531\u4e8e\u53cd\u5e94\u5f15\u8d77\u7684\u8f93\u6ce8\u4e2d\u65ad\u53d1\u751f\u7387\u4e3a<span>35%<\/span>\u3002\u8f93\u6db2\u4e2d\u65ad\u540e\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u53ef\u5728\u5ba4\u6e29\u4e0b\u4fdd\u5b58<span>15<\/span>\u5c0f\u65f6\uff08\u5305\u62ec\u8f93\u6ce8\u65f6\u95f4\uff09\u3002\u53d1\u751f<span>1<\/span>\uff5e<span>2<\/span>\u7ea7\uff08\u8f7b\u4e2d\u5ea6\uff09\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\u7684\u75c7\u72b6\u6d88\u9000\u540e\uff0c\u53ef\u4ee5\u8003\u8651\u91cd\u65b0\u5f00\u59cb\u8f93\u6ce8\uff0c\u4f46\u662f\u901f\u7387\u4e0d\u5f97\u5927\u4e8e\u53d1\u751f<span>IRR<\/span>\u65f6\u8f93\u6ce8\u901f\u7387\u7684\u4e00\u534a\u3002\u5982\u679c\u60a3\u8005\u672a\u53d1\u751f\u4efb\u4f55\u8fdb\u4e00\u6b65\u7684<span>IRR<\/span>\u75c7\u72b6\uff0c\u53ef\u4ee5\u7ee7\u7eed\u9012\u589e\u8f93\u6ce8\u901f\u7387\uff0c\u589e\u91cf\u548c\u95f4\u9694\u89c6\u4e34\u5e8a\u60c5\u51b5\u800c\u5b9a\uff0c\u76f4\u81f3\u6700\u5927\u901f\u7387<span>200ml\/<\/span>\u5c0f\u65f6\u3002\u53d1\u751f<span>3<\/span>\u7ea7\uff08\u91cd\u5ea6\uff09\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\u7684\u75c7\u72b6\u6d88\u9000\u540e\uff0c\u53ef\u4ee5\u8003\u8651\u91cd\u65b0\u5f00\u59cb\u8f93\u6ce8\uff0c\u4f46\u662f\u901f\u7387\u4e0d\u5f97\u5927\u4e8e\u53d1\u751f<span>IRR<\/span>\u65f6\u8f93\u6ce8\u901f\u7387\u7684\u4e00\u534a\u3002\u5982\u679c\u60a3\u8005\u6ca1\u6709\u51fa\u73b0\u5176\u4ed6\u75c7\u72b6\uff0c\u53ef\u4ee5\u91cd\u65b0\u5f00\u59cb\u9012\u589e\u8f93\u6ce8\u901f\u7387\uff0c\u589e\u91cf\u548c\u95f4\u9694\u89c6\u4e34\u5e8a\u60c5\u51b5\u800c\u5b9a\u3002\u5982\u679c\u518d\u6b21\u53d1\u751f<span>3<\/span>\u7ea7\u75c7\u72b6\uff0c\u5e94\u91cd\u590d\u4e0a\u8ff0\u6b65\u9aa4\u3002\u7b2c\u4e09\u6b21\u53d1\u751f<span>\u22653<\/span>\u7ea7\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\u65f6\uff0c\u5e94\u6c38\u4e45\u7ec8\u6b62\u672c\u54c1\u6cbb\u7597\u3002\u53d1\u751f<span>4<\/span>\u7ea7\uff08\u5371\u53ca\u751f\u547d\uff09<span>IRR<\/span>\uff0c\u5e94\u6c38\u4e45\u7ec8\u6b62\u672c\u54c1\u6cbb\u7597\u3002\u6bcf\u6b21\u8f93\u6ce8\u672c\u54c1\u524d<span>1<\/span>\uff5e<span>3<\/span>\u5c0f\u65f6\u7ed9\u4e88\u6240\u6709\u60a3\u8005\u4ee5\u4e0b\u8f93\u6ce8\u524d\u7528\u836f\uff0c\u53ef\u4ee5\u964d\u4f4e<span>IRR<\/span>\u98ce\u9669\uff1a\uff08<span>1<\/span>\uff09\u7cd6\u76ae\u8d28\u6fc0\u7d20\uff08\u957f\u6548\u6216\u4e2d\u6548\uff09\uff1a\u9759\u8109\u8f93\u6ce8<span>100mg<\/span>\u7532\u6cfc\u5c3c\u9f99\u6216\u7b49\u6548\u836f\u7269\u3002\u5728\u7b2c\u4e8c\u6b21\u8f93\u6ce8\u540e\uff0c\u53ef\u4ee5\u51cf\u5c11\u7cd6\u76ae\u8d28\u6fc0\u7d20\u5242\u91cf\uff08\u53e3\u670d\u6216\u9759\u8109\u5185\u7ed9\u4e88\u7532\u6cfc\u5c3c\u9f99<span>60mg<\/span>\uff09\u3002\uff08<span>2<\/span>\uff09\u9000\u70ed\u5242\uff08\u53e3\u670d\u5bf9\u4e59\u9170\u6c28\u57fa\u915a<span>650<\/span>\uff5e<span>1000mg<\/span>\uff09\u3002\uff08<span>3<\/span>\uff09\u6297\u7ec4\u80fa\u836f\uff08\u53e3\u670d\u6216\u9759\u8109\u5185\u7ed9\u4e88\u82ef\u6d77\u62c9\u660e<span>25<\/span>\uff5e<span>50mg<\/span>\u6216\u7b49\u6548\u836f\u7269\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fdf\u53d1\u6027\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\uff1a\u8868\u73b0\u4e3a\u5ef6\u8fdf\u53d1\u70ed\u3002\u53ef\u5728\u6bcf\u6b21\u8f93\u6ce8\u672c\u54c1\u540e<span>2<\/span>\u5929\uff08\u4ece\u8f93\u6ce8\u540e\u6b21\u65e5\u5f00\u59cb\uff09\u6bcf\u5929\u7ed9\u4e88\u53e3\u670d\u7cd6\u76ae\u8d28\u6fc0\u7d20\uff08<span>20mg<\/span>\u7532\u6cfc\u5c3c\u9f99\u6216\u7b49\u6548\u5242\u91cf\u7684\u4e2d\u6548<span>\/<\/span>\u957f\u6548\u7cd6\u76ae\u8d28\u6fc0\u7d20\uff0c\u89c6\u5f53\u5730\u6807\u51c6\u800c\u5b9a\uff09\u964d\u4f4e\u8fdf\u53d1\u6027\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\u7684\u98ce\u9669\u3002\u53e6\u5916\uff0c\u5bf9\u4e8e\u60a3\u6709\u6162\u6027\u963b\u585e\u6027\u80ba\u75be\u75c5\u75c5\u53f2\u7684\u60a3\u8005\uff0c\u5e94\u8003\u8651\u4f7f\u7528\u5305\u62ec\u77ed\u6548\u548c\u957f\u6548\u652f\u6c14\u7ba1\u6269\u5f20\u5242\u4ee5\u53ca\u5438\u5165\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u5728\u5185\u7684\u8f93\u6ce8\u540e\u7528\u836f\u3002\u5728\u524d\u56db\u6b21\u8f93\u6ce8\u4e4b\u540e\uff0c\u5982\u679c\u60a3\u8005\u6ca1\u6709\u53d1\u751f\u91cd\u5927<span>IRR<\/span>\uff0c\u5219\u53ef\u4ee5\u7531\u533b\u5e08\u81ea\u884c\u51b3\u5b9a\u505c\u7528\u8fd9\u4e9b\u5438\u5165\u6027\u8f93\u6ce8\u540e\u836f\u7269\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u8840\u578b\u5224\u5b9a\u7684\u5f71\u54cd\u4ee5\u53ca\u8f93\u8840\u7b56\u7565\uff1a\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u53ef\u4ee5\u4e0e\u7ea2\u7ec6\u80de\u819c\u8868\u9762\u4f4e\u6c34\u5e73\u8868\u8fbe\u7684<span>CD38<\/span>\u6297\u539f\u7ed3\u5408\uff0c\u9020\u6210\u4ea4\u53c9\u914d\u8840\u8fc7\u7a0b\u4e2d\u7684\u95f4\u63a5\u6297\u4eba\u7403\u86cb\u767d\u8bd5\u9a8c\u5047\u9633\u6027\uff0c\u5e72\u6270\u914d\u8840\uff0c\u8fd9\u79cd\u5047\u9633\u6027\u53ef\u80fd\u6301\u7eed\u5230\u672b\u6b21\u8f93\u6ce8\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u540e<span>6<\/span>\u4e2a\u6708\u3002\u5e94\u5728\u60a3\u8005\u5f00\u59cb\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u6cbb\u7597\u524d\u5b8c\u6210\u8840\u578b\u5224\u5b9a\u5e76\u8fdb\u884c\u6297\u4f53\u7b5b\u67e5\u3002\u5728\u8ba1\u5212\u8f93\u8840\u7684\u60c5\u51b5\u4e0b\uff0c\u5e94\u901a\u77e5\u8f93\u8840\u4e2d\u5fc3\u8fd9\u4e00\u95f4\u63a5\u6297\u7403\u86cb\u767d\u8bd5\u9a8c\u7684\u5e72\u6270\u56e0\u7d20\u3002\u5e94\u7528\u4e8c\u786b\u82cf\u7cd6\u9187\u5904\u7406\u5f85\u68c0\u60a3\u8005\u7ea2\u7ec6\u80de\u662f\u5904\u7406\u65b9\u6cd5\u4e4b\u4e00\u3002\u7ea2\u7ec6\u80de\u57fa\u56e0\u5206\u578b\u4e0d\u53d7\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u7684\u5f71\u54cd\uff0c\u53ef\u4ee5\u968f\u65f6\u8fdb\u884c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u6709\u9aa8\u9ad3\u6291\u5236\uff0c\u5e94\u7528\u540e\u9700\u8981\u6ce8\u610f\u8840\u5e38\u89c4\u7684\u76d1\u6d4b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u53ef\u80fd\u4f1a\u5f15\u8d77\u5e26\u72b6\u75b1\u75b9\u611f\u67d3\u98ce\u9669\u589e\u52a0\uff0c\u7ea6<span>3%<\/span>\u7684\u60a3\u8005\u62a5\u544a\u4e86\u5e26\u72b6\u75b1\u75b9\u518d\u6fc0\u6d3b\u3002\u65e0\u8bba\u5355\u836f\u4f7f\u7528\u8fd8\u662f\u4e0e\u5176\u4ed6\u4efb\u610f\u65b9\u6848\u8054\u7528\uff0c\u90fd\u63a8\u8350\u4f7f\u7528\u6297\u75c5\u6bd2\u9884\u9632\u6027\u6cbb\u7597\u6765\u9884\u9632\u5e26\u72b6\u75b1\u75b9\u75c5\u6bd2\u518d\u6fc0\u6d3b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u4f34\u6709\u809d\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u4e0d\u9700\u8981\u8c03\u6574\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u6709\u4e59\u809d\u75c5\u6bd2\u518d\u71c3\u7684\u98ce\u9669\u3002\u5728\u4f7f\u7528\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u6cbb\u7597\u524d\u5e94\u8fdb\u884c\u4e59\u809d\u75c5\u6bd2\u7b5b\u67e5\uff0c\u4e59\u809d\u75c5\u6bd2\u643a\u5e26\u8005\u5e94\u9884\u9632\u6027\u4f7f\u7528\u6291\u5236\u75c5\u6bd2\u590d\u5236\u7684\u836f\u7269\u53ca\u76d1\u6d4b\u75c5\u6bd2\u8f7d\u91cf\uff1b\u5728\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u6cbb\u7597\u4e2d\uff0c\u82e5\u51fa\u73b0\u4e59\u809d\u75c5\u6bd2\u518d\u6fc0\u6d3b\u7684\u60a3\u8005\uff0c\u5e94\u505c\u6b62\u4f7f\u7528\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u53ca\u4efb\u4f55\u8054\u5408\u6fc0\u7d20\u3001\u5316\u7597\uff0c\u5e76\u7ed9\u4e88\u9002\u5f53\u7684\u6cbb\u7597\u3002\u5bf9\u4e8e\u4e59\u809d\u75c5\u6bd2\u8840\u6e05\u5b66\u68c0\u6d4b\u7ed3\u679c\u5448\u9633\u6027\u7684\u60a3\u8005\uff0c\u5e94\u5728\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u4ee5\u53ca\u6cbb\u7597\u7ed3\u675f\u540e\u81f3\u5c11<span>6<\/span>\u4e2a\u6708\u5185\u76d1\u6d4b\u4e59\u809d\u75c5\u6bd2\u518d\u6fc0\u6d3b\u7684\u4e34\u5e8a\u548c\u5b9e\u9a8c\u5ba4\u6307\u5f81\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5176\u4ed6\u6cbb\u7597\uff1a\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u8054\u5408\u5730\u585e\u7c73\u677e\u53ca\u787c\u66ff\u4f50\u7c73\u7528\u4e8e\u521d\u8bca\u7684\u7cfb\u7edf\u6027\u8f7b\u94fe\u578b\u6dc0\u7c89\u6837\u53d8\u4e2d\u7684<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5728\u8fdb\u884c\u4e2d\uff0c\u4e2d\u671f\u5206\u6790\u542b\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u7ec4\u8f83\u5bf9\u7167\u7ec4\u8840\u6db2\u5b66\u7f13\u89e3\u7387\u660e\u663e\u589e\u52a0\u3002\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u8054\u5408\u5176\u4ed6\u836f\u7269\u5728<span>NCCN<\/span>\u6307\u5357\u5df2\u7ecf\u83b7\u6279\u7528\u4e8e\u96be\u6cbb\u590d\u53d1\u4ee5\u53ca\u521d\u6cbb\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u6cbb\u7597\uff0c\u5305\u62ec\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u8054\u5408\u6765\u90a3\u5ea6\u80fa\u53ca\u5730\u585e\u7c73\u677e\u7528\u4e8e\u590d\u53d1\u60a3\u8005\u4ee5\u53ca\u8001\u5e74\u521d\u6cbb\u60a3\u8005\uff0c\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u8054\u5408\u787c\u66ff\u4f50\u7c73\u53ca\u5730\u585e\u7c73\u677e\u7528\u4e8e\u96be\u6cbb\u590d\u53d1\u60a3\u8005\uff0c\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u8054\u5408\u787c\u66ff\u4f50\u7c73\u3001\u7f8e\u6cd5\u4ed1\u53ca\u918b\u9178\u6cfc\u5c3c\u677e\u7528\u4e8e\u8001\u5e74\u521d\u6cbb\u60a3\u8005\uff0c\u8fbe\u96f7\u59a5\u5c24\u5355\u6297\u8054\u5408\u787c\u66ff\u4f50\u7c73\u3001\u6c99\u5229\u5ea6\u80fa\u53ca\u5730\u585e\u7c73\u677e\u7528\u4e8e\u5e74\u8f7b\u521d\u6cbb\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u5341\u4e00\u3001\u82a6\u53ef\u66ff\u5c3c<span> Ruxolitinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>5mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u4e2d\u5371\u6216\u9ad8\u5371\u7684\u539f\u53d1\u6027\u9aa8\u9ad3\u7ea4\u7ef4\u5316\uff08\u4ea6\u79f0\u4e3a\u6162\u6027\u7279\u53d1\u6027\u9aa8\u9ad3\u7ea4\u7ef4\u5316\uff09\u3001\u771f\u6027\u7ea2\u7ec6\u80de\u589e\u591a\u75c7\u7ee7\u53d1\u7684\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u6216\u539f\u53d1\u6027\u8840\u5c0f\u677f\u589e\u591a\u75c7\u7ee7\u53d1\u7684\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u7684\u6210\u5e74\u60a3\u8005\uff0c\u6cbb\u7597\u75be\u75c5\u76f8\u5173\u813e\u80bf\u5927\u6216\u75be\u75c5\u76f8\u5173\u75c7\u72b6\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u5242\u91cf\uff1a\u6309\u7167\u8840\u5c0f\u677f\u8ba1\u6570\u7ed9\u4e88\u8d77\u59cb\u5242\u91cf\u3002\uff08<span>1<\/span>\uff09\u8840\u5c0f\u677f\u8ba1\u6570\u5728\uff08<span>100<\/span>\uff5e<span>200<\/span>\uff09<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u00d7<span>10<sup>9<\/sup>\/L<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u8d77\u59cb\u5242\u91cf\u4e3a<span>15mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u3002\uff08<span>2<\/span>\uff09\u8840\u5c0f\u677f\u8ba1\u6570\uff1e<span>200<\/span><\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u00d7<span>10<sup>9<\/sup>\/L<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u8d77\u59cb\u5242\u91cf\u4e3a<span>20mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u3002\uff08<span>3<\/span>\uff09\u8840\u5c0f\u677f\u8ba1\u6570\u5728\uff08<span>50<\/span>\uff5e<span>100<\/span>\uff09<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u00d7<span>10<sup>9<\/sup>\/L<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u8d77\u59cb\u5242\u91cf\u4e3a<span>5mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u53ef\u80fd\u9020\u6210\u8840\u6db2\u7cfb\u7edf\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u8840\u5c0f\u677f\u51cf\u5c11\u3001\u8d2b\u8840\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u3002\u6cbb\u7597\u524d\uff0c\u5fc5\u987b\u8fdb\u884c\u5168\u8840\u7ec6\u80de\u8ba1\u6570\u68c0\u67e5\uff0c\u4e4b\u540e\u6bcf\u5468\u76d1\u6d4b\u4e00\u6b21\uff0c<span>4<\/span>\u5468\u540e\u53ef\u6bcf<span>2<\/span>\uff5e<span>4<\/span>\u5468\u76d1\u6d4b\u4e00\u6b21\uff0c\u76f4\u5230\u8fbe\u5230\u7a33\u5b9a\uff0c\u7136\u540e\u53ef\u4ee5\u6839\u636e\u4e34\u5e8a\u9700\u8981\u8fdb\u884c\u76d1\u6d4b\u3002\u5f53\u51fa\u73b0\u8840\u5c0f\u677f\u51cf\u5c11\u6216\u8d2b\u8840\u65f6\uff0c\u53ef\u51cf\u5c11\u5242\u91cf\u6216\u6682\u65f6\u505c\u6b62\u7528\u836f\uff0c\u5fc5\u8981\u65f6\u8f93\u6ce8\u8840\u5c0f\u677f\u6216\u7ea2\u7ec6\u80de\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e2d\u65ad\u6216\u7ec8\u6b62\u672c\u54c1\u6cbb\u7597\u540e\uff0c\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u7684\u75c7\u72b6\u53ef\u80fd\u5728\u5927\u7ea6\u4e00\u5468\u540e\u518d\u6b21\u51fa\u73b0\u3002\u82e5\u975e\u5fc5\u987b\u7d27\u6025\u7ec8\u6b62\u6cbb\u7597\uff0c\u5e94\u53ef\u4ee5\u8003\u8651\u9010\u6b65\u51cf\u5c11\u672c\u54c1\u7684\u7528\u836f\u5242\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u4e0e\u5f3a\u6548<span>CYP3A4<\/span>\u6291\u5236\u5242\u6216<span>CYP2C9<\/span>\u548c<span>CYP3A4<\/span>\u9176\u53cc\u91cd\u6291\u5236\u5242\u5408\u5e76\u4f7f\u7528\u65f6\uff0c\u6bcf\u5929\u603b\u5242\u91cf\u5e94\u51cf\u5c11\u7ea6<span>50%<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p><b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><br \/>\n<\/span><\/b> <\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ccc\u5c3f\u7cfb\u7edf\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e00\u3001\u4f9d\u7ef4\u83ab\u53f8<span> Everolimus<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>2.5mg<\/span>\u3001<span>5mg<\/span>\u3001<span>10mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u63a5\u53d7\u8212\u5c3c\u66ff\u5c3c\u6216\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u5931\u8d25\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\uff08<span>RCC<\/span>\uff09\uff0c\u6570\u636e\u4e3b\u8981\u57fa\u4e8e\u900f\u660e\u7ec6\u80de\u80be\u764c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0e\u4ed1\u4f10\u66ff\u5c3c\u8054\u7528\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u6297\u8840\u7ba1\u751f\u6210\u836f\u7269\u6cbb\u7597\u5931\u8d25\u6216\u8fdb\u5c55\u7684\u665a\u671f<span>RCC<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u809d\u529f\u80fd\u635f\u4f24\u4f1a\u4f7f\u4f9d\u7ef4\u83ab\u53f8\u66b4\u9732\u91cf\u589e\u52a0\uff0c\u6309\u5982\u4e0b\u65b9\u5f0f\u8fdb\u884c\u7ed9\u836f\u8c03\u6574\uff1a\uff08<span>1<\/span>\uff09\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\uff08<span>Child-Pugh A<\/span>\u7ea7\uff09\uff1a\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u5929<span>7.5mg<\/span>\uff1b\u5982\u679c\u4e0d\u80fd\u5f88\u597d\u5730\u8010\u53d7\uff0c\u53ef\u5c06\u5242\u91cf\u964d\u81f3\u6bcf\u5929<span>5mg<\/span>\u3002\uff08<span>2<\/span>\uff09\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\uff08<span>Child-Pugh B<\/span>\u7ea7\uff09\uff1a\u63a8\u8350\u5242\u91cf\u662f\u6bcf\u5929<span>5mg<\/span>\uff1b\u5982\u679c\u4e0d\u80fd\u5f88\u597d\u5730\u8010\u53d7\uff0c\u53ef\u5c06\u5242\u91cf\u964d\u81f3\u6bcf\u5929<span>2.5mg<\/span>\u3002\uff08<span>3<\/span>\uff09\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\uff08<span>Child-Pugh C<\/span>\u7ea7\uff09\uff1a\u5982\u679c\u9884\u671f\u7684\u83b7\u76ca\u9ad8\u4e8e\u98ce\u9669\uff0c\u53ef\u4ee5\u91c7\u7528\u6bcf\u5929<span>2.5mg<\/span>\uff0c\u4f46\u4e0d\u5f97\u8d85\u8fc7\u8fd9\u4e00\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u53e3\u8154\u708e\u7b49\uff1b\u5e94\u7279\u522b\u6ce8\u610f\u975e\u611f\u67d3\u6027\u80ba\u708e\u7684\u53d1\u751f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u5408\u5e76\u4f7f\u7528\u5f3a\u6548<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u5e94\u907f\u514d\u63a5\u79cd\u6d3b\u75ab\u82d7\uff0c\u907f\u514d\u4e0e\u63a5\u79cd\u8fc7\u6d3b\u75ab\u82d7\u7684\u4eba\u5bc6\u5207\u63a5\u89e6\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u548c\u4ed1\u4f10\u66ff\u5c3c\u7684\u8054\u5408\u6cbb\u7597\u7684\u5176\u4ed6\u6ce8\u610f\u4e8b\u9879\u8bf7\u53c2\u8003\u201c\u4ed1\u4f10\u66ff\u5c3c\u201d\u90e8\u5206\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u7d22\u62c9\u975e\u5c3c<span> Sorafenib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>200mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u665a\u671f\u80be\u764c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.CYP3A4<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8bf1\u5bfc\u5242\u8054\u5408\u7d22\u62c9\u975e\u5c3c\u53ef\u51cf\u4f4e\u7d22\u62c9\u975e\u5c3c\u7684\u836f\u7269\u6d53\u5ea6\uff0c\u800c\u6839\u636e\u76ee\u524d\u6570\u636e\uff0c<span>CYP3A4<\/span>\u6291\u5236\u5242\u548c\u7d22\u62c9\u975e\u5c3c\u5728\u4e34\u5e8a\u836f\u4ee3\u52a8\u529b\u5b66\u65b9\u9762\u4e0d\u592a\u53ef\u80fd\u5b58\u5728\u76f8\u4e92\u4f5c\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7a7a\u8179\u7ed9\u836f\uff0c\u7528\u836f\u524d\u65e0\u9700\u8fdb\u884c\u57fa\u56e0\u68c0\u6d4b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b58\u5728\u53ef\u7591\u7684\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u65f6\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u548c<span>\/<\/span>\u6216\u51cf\u5c11\u7d22\u62c9\u975e\u5c3c\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u6709\u8179\u6cfb\u3001\u4e4f\u529b\u3001\u8131\u53d1\u3001\u611f\u67d3\u3001\u624b\u8db3\u76ae\u80a4\u53cd\u5e94\u3001\u76ae\u75b9\u3002\u907f\u514d\u5e94\u7528<span>CYP3A4<\/span>\u5f3a\u6548\u6291\u5236\u5242\u548c\u5f3a\u6548\u8bf1\u5bfc\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u7d22\u62c9\u975e\u5c3c\u6216\u672c\u54c1\u4efb\u4e00\u975e\u6d3b\u6027\u6210\u5206\u6709\u4e25\u91cd\u8fc7\u654f\u75c7\u72b6\u7684\u60a3\u8005\u7981\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e09\u3001\u8212\u5c3c\u66ff\u5c3c<span> Sunitinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>12.5mg<\/span>\u3001<span>25mg<\/span>\u3001<span>37.5mg<\/span>\u3001<span>50mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u665a\u671f\u80be\u764c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a<span>50mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u53e3\u670d\uff0c\u670d\u836f<span>4<\/span>\u5468\uff0c\u505c\u836f<span>2<\/span>\u5468\uff08<span>4\/2<\/span>\u7ed9\u836f\u65b9\u6848\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u60a3\u8005\u4e2a\u4f53\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u4ee5<span>12.5mg<\/span>\u4e3a\u68af\u5ea6\u5355\u4f4d\u9010\u6b65\u8c03\u6574\u5242\u91cf\u3002\u6bcf\u5929\u6700\u9ad8\u5242\u91cf\u4e0d\u8d85\u8fc7<span>75mg<\/span>\uff0c\u6700\u4f4e\u5242\u91cf\u4e3a<span>25mg<\/span>\u3002\u6839\u636e\u60a3\u8005\u4e2a\u4f53\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u60c5\u51b5\u53ef\u80fd\u9700\u8981\u4e2d\u65ad\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u4e0e\u5f3a\u6548<span>CYP3A4\/5<\/span>\u6291\u5236\u5242\u6216\u8bf1\u5bfc\u5242\u5408\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8212\u5c3c\u66ff\u5c3c\u670d\u7528<span>4<\/span>\u5468\uff0c\u505c\u836f<span>2<\/span>\u5468\uff08<span>4\/2<\/span>\u7ed9\u836f\u65b9\u6848\uff09\u53ef\u80fd\u4f1a\u53d1\u73b0\u767d\u7ec6\u80de\u53ca\u8840\u5c0f\u677f\u4e0b\u964d\u7b49\u4e25\u91cd\u9aa8\u9ad3\u6291\u5236\uff0c\u56e0\u6b64\u7528\u836f\u671f\u95f4\u9700\u8981\u5bc6\u5207\u76d1\u6d4b\u8840\u5e38\u89c4\u3002\u5fc5\u8981\u65f6\u53ef\u91c7\u7528<span>2\/1<\/span>\u7ed9\u836f\u65b9\u6848\uff0c\u5373\u8212\u5c3c\u66ff\u5c3c\u670d\u7528<span>2<\/span>\u5468\uff0c\u505c\u836f<span>1<\/span>\u5468\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56db\u3001\u963f\u6614\u66ff\u5c3c<span> Axitinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>1mg<\/span>\u3001<span>5mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e00\u79cd\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u6216\u7ec6\u80de\u56e0\u5b50\u6cbb\u7597\u5931\u8d25\u7684\u8fdb\u5c55\u671f<span>RCC<\/span>\u7684\u6210\u4eba\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u9002\u7528\u4e8e\u665a\u671f\u80be\u900f\u660e\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u6614\u66ff\u5c3c\u63a8\u8350\u7684\u8d77\u59cb\u53e3\u670d\u5242\u91cf\u4e3a<span>5mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u53ef\u4e0e\u98df\u7269\u540c\u670d\u6216\u7a7a\u8179\u7ed9\u836f\uff0c\u6bcf\u5929\u4e24\u6b21\u7ed9\u836f\u7684\u65f6\u95f4\u95f4\u9694\u7ea6\u4e3a<span>12<\/span>\u5c0f\u65f6\u3002\u53ea\u8981\u89c2\u5bdf\u5230\u4e34\u5e8a\u83b7\u76ca\uff0c\u5c31\u5e94\u7ee7\u7eed\u6cbb\u7597\u76f4\u81f3\u53d1\u751f\u4e0d\u80fd\u63a5\u53d7\u7684\u6bd2\u6027\u3002\u5982\u679c\u60a3\u8005\u5455\u5410\u6216\u6f0f\u670d\u4e00\u6b21\u5242\u91cf\uff0c\u4e0d\u5e94\u53e6\u5916\u670d\u7528\u4e00\u6b21\u5242\u91cf\uff0c\u5e94\u6309\u5e38\u89c4\u670d\u7528\u4e0b\u4e00\u6b21\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u6839\u636e\u60a3\u8005\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u7684\u4e2a\u4f53\u5dee\u5f02\u589e\u52a0\u6216\u964d\u4f4e\u5242\u91cf\uff1a\uff08<span>1<\/span>\uff09\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\uff0c\u6ee1\u8db3\u4e0b\u8ff0\u6807\u51c6\u7684\u60a3\u8005\u53ef\u589e\u52a0\u5242\u91cf\uff1a\u80fd\u8010\u53d7\u963f\u6614\u66ff\u5c3c\u81f3\u5c11\u4e24\u5468\u8fde\u7eed\u6cbb\u7597\u3001\u672a\u51fa\u73b0<span>2<\/span>\u7ea7\u4ee5\u4e0a\u4e0d\u826f\u53cd\u5e94\u3001\u8840\u538b\u6b63\u5e38\u3001\u672a\u63a5\u53d7\u964d\u538b\u836f\u7269\u6cbb\u7597\u3002\u5f53\u63a8\u8350\u4ece<span>5mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u5f00\u59cb\u589e\u52a0\u5242\u91cf\u65f6\uff0c\u53ef\u5c06\u963f\u6614\u66ff\u5c3c\u5242\u91cf\u589e\u52a0\u81f3<span>7mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u7136\u540e\u91c7\u7528\u76f8\u540c\u6807\u51c6\uff0c\u8fdb\u4e00\u6b65\u5c06\u5242\u91cf\u589e\u52a0\u81f3<span>10mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u3002\uff08<span>2<\/span>\uff09\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u6216\u6c38\u4e45\u7ec8\u6b62\u7ed9\u836f\uff0c\u6216\u964d\u4f4e\u963f\u6614\u66ff\u5c3c\u5242\u91cf\u3002\u5982\u679c\u9700\u8981\u4ece<span>5mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u5f00\u59cb\u51cf\u91cf\uff0c\u5219\u63a8\u8350\u5242\u91cf\u4e3a<span>3mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u3002\u5982\u679c\u9700\u8981\u518d\u6b21\u51cf\u91cf\uff0c\u5219\u63a8\u8350\u5242\u91cf\u4e3a<span>2mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u4e0e\u5f3a\u6548<span>CYP3A4\/5<\/span>\u6291\u5236\u5242\u6216\u8bf1\u5bfc\u5242\u5408\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u665a\u671f\u80be\u900f\u660e\u7ec6\u80de\u764c\u65f6\uff0c\u63a8\u8350\u963f\u6614\u66ff\u5c3c\u7684\u5242\u91cf\u4e3a<span>5mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u5982\u80fd\u8010\u53d7\uff0c\u53ef\u8003\u8651\u5242\u91cf\u6ef4\u5b9a\u3002\u8054\u5408\u6cbb\u7597\u671f\u95f4\u5e15\u535a\u5229\u73e0\u5355\u6297\u7684\u7528\u836f\u8981\u70b9\u8bf7\u53c2\u89c1\u201c\u5e15\u535a\u5229\u73e0\u5355\u6297\u201d\u90e8\u5206\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e94\u3001\u57f9\u5511\u5e15\u5c3c<span> Pazopanib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>200mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u9002\u7528\u4e8e\u665a\u671f<span>RCC<\/span>\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u548c\u66fe\u63a5\u53d7\u7ec6\u80de\u56e0\u5b50\u6cbb\u7597\u7684\u665a\u671f<span>RCC<\/span>\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57f9\u5511\u5e15\u5c3c\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>800mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u7a7a\u8179\u670d\u836f\u3002\u5982\u679c\u6f0f\u670d\u5242\u91cf\uff0c\u4e14\u8ddd\u4e0b\u6b21\u5242\u91cf\u7684\u670d\u7528\u65f6\u95f4\u4e0d\u8db3<span>12<\/span>\u5c0f\u65f6\uff0c\u5219\u4e0d\u5e94\u8865\u670d\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u8c03\u6574\u5e94\u6839\u636e\u4e2a\u4f53\u8010\u53d7\u60c5\u51b5\uff0c\u6309<span>200mg<\/span>\u7684\u5e45\u5ea6\u9010\u6b65\u9012\u589e\u6216\u9012\u51cf\uff0c\u4ee5\u63a7\u5236\u4e0d\u826f\u53cd\u5e94\u3002\u57f9\u5511\u5e15\u5c3c\u7684\u5242\u91cf\u4e0d\u5e94\u8d85\u8fc7<span>800mg<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u57f9\u5511\u5e15\u5c3c\u4f7f\u7528\u671f\u95f4\uff0c\u8f7b\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5e94\u614e\u7528\u57f9\u5511\u5e15\u5c3c\uff0c\u5e76\u4e14\u5e94\u5bc6\u5207\u76d1\u6d4b\uff0c\u5bf9\u4e8e\u57fa\u7ebf\u603b\u80c6\u7ea2\u7d20\u7684\u6570\u503c\u2264<span>1.5<\/span>\u500d<span>ULN<\/span>\uff0c\u4e14<span>AST<\/span>\u53ca<span>ALT<\/span>\u7684\u6570\u503c\u2264<span>2<\/span>\u500d<span>ULN<\/span>\u7684\u60a3\u8005\uff0c\u5176\u5242\u91cf\u8c03\u6574\u53c2\u89c1\u9488\u5bf9\u836f\u7269\u6027\u809d\u6bd2\u6027\u7684\u5242\u91cf\u8c03\u6574\u6307\u5357\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u809d\u529f\u80fd\u635f\u4f24\u548c\u9ad8\u8840\u538b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u540c\u65f6\u4f7f\u7528<span>CYP3A4<\/span>\u3001<span>P-<\/span>\u7cd6\u86cb\u767d\u6216\u4e73\u817a\u764c\u8010\u836f\u86cb\u767d\u7684\u5f3a\u6291\u5236\u5242\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u516d\u3001\u4ed1\u4f10\u66ff\u5c3c<span> Lenvatinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>4mg<\/span>\u3001<span>10mg<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0e\u4f9d\u7ef4\u83ab\u53f8\u8054\u7528\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u6297\u8840\u7ba1\u751f\u6210\u836f\u7269\u6cbb\u7597\u5931\u8d25\u6216\u8fdb\u5c55\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\uff08<span>RCC<\/span>\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a<span>18mg<\/span>\u53e3\u670d\u8054\u5408\u4f9d\u7ef4\u83ab\u53f8<span>5mg<\/span>\u53e3\u670d\uff0c\u6bcf\u5929\u4e00\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u5408\u5e76\u4f7f\u7528\u5f3a\u6548<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u8fc7\u7a0b\u9700\u5bc6\u5207\u76d1\u6d4b\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f\u3002\u5728\u80be\u764c\u6cbb\u7597\u4e2d\uff0c\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u2265<span>30%<\/span>\uff09\u4e3a\u8179\u6cfb\u3001\u4e4f\u529b\u3001\u9aa8\u5173\u8282\u75bc\u75db\u3001\u98df\u6b32\u51cf\u9000\u3001\u6076\u5fc3\u3001\u5455\u5410\u3001\u53e3\u8154\u708e\u3001\u9ad8\u8840\u538b\u7b49\u3002\u5fc5\u8981\u65f6\u51cf\u91cf\u3001\u6682\u505c\u7528\u836f\u6216\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51cf\u91cf\u63a8\u8350\uff1a\u9700\u6309\u7167<span>18mg<\/span>\u2192<span>14mg<\/span>\u2192<span>10mg<\/span>\u2192<span>8mg<\/span>\u7684\u5242\u91cf\u51cf\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e25\u91cd\u80be\u529f\u80fd\u635f\u4f24\u548c\u809d\u529f\u80fd\u635f\u4f24\u7684\u60a3\u8005\uff0c\u4ed1\u4f10\u66ff\u5c3c\u7684\u5242\u91cf\u5e94\u6539\u4e3a<span>10mg<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4ed1\u4f10\u66ff\u5c3c\u5e94\u5728\u6bcf\u5929\u56fa\u5b9a\u65f6\u95f4\u670d\u7528\uff0c\u7a7a\u8179\u6216\u4e0e\u98df\u7269\u540c\u670d\u5747\u53ef\u3002\u5982\u679c\u60a3\u8005\u9057\u6f0f\u4e00\u6b21\u7528\u836f\u4e14\u65e0\u6cd5\u5728<span>12<\/span>\u5c0f\u65f6\u5185\u670d\u7528\uff0c\u65e0\u9700\u8865\u670d\uff0c\u5e94\u6309\u5e38\u89c4\u7528\u836f\u65f6\u95f4\u8fdb\u884c\u4e0b\u4e00\u6b21\u670d\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e03\u3001\u7eb3\u6b66\u5229\u5c24\u5355\u6297<span> Nivolumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>40mg<\/span>\uff08<span>4ml<\/span>\uff09<span>\/<\/span>\u74f6\u3001<span>100mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\u9002\u7528\u4e8e\u56fd\u9645\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\u8054\u5408\u6570\u636e\u5e93\uff08<span>IMDC<\/span>\uff09\u8bc4\u5206\u4e3a\u4e2d\u9ad8\u5371\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\u7528\u4e8e<span>IMDC<\/span>\u8bc4\u5206\u4e3a\u4e2d\u9ad8\u5371\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u57fa\u4e8e<span>CheckMate214<\/span>\u7814\u7a76\u3002\u8be5\u6cbb\u7597\u65b9\u6cd5\u5df2\u83b7\u5f97\u7f8e\u56fd<span>FDA<\/span>\u548c\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\u83b7\u6279\uff0c\u63a8\u8350\u4e34\u5e8a\u5242\u91cf\u662f\u7eb3\u6b66\u5229\u5c24\u5355\u6297<span>3mg\/kg<\/span>\u6bcf\u6b21\u6301\u7eed\u81f3\u5c11<span>60<\/span>\u5206\u949f<span>+<\/span>\u4f0a\u5339\u6728\u5355\u6297<span>1mg\/kg<\/span>\u6bcf\u6b21\u6301\u7eed\u81f3\u5c11<span>30<\/span>\u5206\u949f\uff0c\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c\u8fde\u7eed<span>4<\/span>\u6b21\u540e\uff0c\u6539\u4e3a\u7eb3\u6b66\u5229\u5c24\u5355\u6297<span>3mg\/kg<\/span>\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff0c\u6bcf\u6b21\u6301\u7eed\u81f3\u5c11<span>60<\/span>\u5206\u949f\u3002\u4f46\u8be5\u9002\u5e94\u8bc1\u5c1a\u672a\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\uff0c\u53ef\u5728\u4e0e\u60a3\u8005\u5145\u5206\u6c9f\u901a\u7684\u60c5\u51b5\u4e0b\u8003\u8651\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.IMDC<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8bc4\u5206\u5185\u5bb9\u5305\u62ec\uff1a\u8d2b\u8840\uff08\u4f4e\u4e8e\u6b63\u5e38\u503c\u4e0b\u9650\uff09\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u5347\u9ad8\uff08\u9ad8\u4e8e\u6b63\u5e38\u503c\u4e0a\u9650\uff09\u3001\u8840\u5c0f\u677f\u5347\u9ad8\uff08\u9ad8\u4e8e\u6b63\u5e38\u503c\u4e0a\u9650\uff09\u3001<span>KPS<\/span>\u8bc4\u5206\uff1c<span>80<\/span>\u3001\u4e00\u7ebf\u6cbb\u7597\u8ddd\u8bca\u65ad\u65f6\u95f4\uff1c<span>1<\/span>\u5e74\u3001\u9ad8\u9499\u8840\u75c7\u3002\u6bcf\u9879\u4e3a<span>1<\/span>\u5206\u3002\u603b\u5206<span>0<\/span>\u5206\u4e3a\u4f4e\u5371\u4eba\u7fa4\uff0c<span>1<\/span>\uff5e<span>2<\/span>\u5206\u4e3a\u4e2d\u5371\u4eba\u7fa4\uff0c\u2265<span>3<\/span>\u5206\u4e3a\u9ad8\u5371\u4eba\u7fa4\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56e0\u90e8\u5206\u60a3\u8005\u4f7f\u7528\u514d\u75ab\u6cbb\u7597\u53ef\u80fd\u4f1a\u51fa\u73b0\u5047\u6027\u8fdb\u5c55\uff08\u6cbb\u7597\u6700\u521d\u6570\u6708\u5185\u80bf\u7624\u51fa\u73b0\u77ed\u6682\u6027\u589e\u5927\u6216\u51fa\u73b0\u65b0\u7684\u5c0f\u75c5\u7076\uff0c\u968f\u540e\u80bf\u7624\u7f29\u5c0f\u751a\u81f3\u6d88\u5931\uff09\uff0c\u6545\u53ea\u8981\u89c2\u5bdf\u5230\u4e34\u5e8a\u83b7\u76ca\uff0c\u5e94\u7ee7\u7eed\u4f7f\u7528\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\u6216\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u5355\u836f\u6cbb\u7597\u81f3\u660e\u786e\u75be\u75c5\u8fdb\u5c55\u6216\u53d1\u751f\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u4f46\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u6682\u505c\u7ed9\u836f\u6216\u505c\u836f\u3002\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u5224\u65ad\u5176\u4e0e\u836f\u7269\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u53ca\u4f0a\u5339\u6728\u5355\u6297\u7684\u76f8\u5173\u6027\u3002\u5982\u53d1\u751f<span>4<\/span>\u7ea7\u6216\u590d\u53d1\u6027<span>3<\/span>\u7ea7\uff0c\u867d\u7136\u8fdb\u884c\u6cbb\u7597\u8c03\u6574\u4f46\u4ecd\u6301\u7eed\u5b58\u5728<span>2<\/span>\u7ea7\u6216<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u5145\u5206\u5206\u6790\u5f15\u53d1\u8be5\u4e0d\u826f\u53cd\u5e94\u7684\u53ef\u80fd\u7684\u836f\u7269\uff0c\u53ef\u80fd\u9700\u8981\u6c38\u4e45\u6027\u505c\u7528\u53cc\u6297\u6216\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6216\u4f0a\u5339\u6728\u5355\u6297\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8001\u5e74\u60a3\u8005\u6570\u636e\u6709\u9650\uff0c\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u6570\u636e\u6709\u9650\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u6ca1\u6709\u5bf9\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u8fdb\u884c\u672c\u54c1\u7684\u76f8\u5173\u7814\u7a76\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u00b1\u4f0a\u5339\u6728\u5355\u6297\u53ef\u5f15\u8d77\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u3002\u56e0\u4e3a\u4e0d\u826f\u53cd\u5e94\u53ef\u80fd\u5728\u514d\u75ab\u6cbb\u7597\u671f\u95f4\u6216\u514d\u75ab\u6cbb\u7597\u505c\u6b62\u540e\u7684\u4efb\u4f55\u65f6\u95f4\u53d1\u751f\uff0c\u5e94\u6301\u7eed\u8fdb\u884c\u60a3\u8005\u76d1\u6d4b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u6682\u505c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u5e76\u7ed9\u4e88\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u975e\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6027\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u3002\u5fc5\u8981\u65f6\u4e0e\u76f8\u5173\u9886\u57df\u5b66\u79d1\u8fdb\u884c\u591a\u5b66\u79d1\u8bca\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u60a3\u8005\u63a5\u53d7\u514d\u75ab\u6291\u5236\u5242\u91cf\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u6cbb\u7597\u671f\u95f4\uff0c\u4e0d\u53ef\u91cd\u65b0\u4f7f\u7528\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u516b\u3001\u5e15\u535a\u5229\u73e0\u5355\u6297<span> Pembrolizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>4ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u963f\u6614\u66ff\u5c3c\u9002\u7528\u4e8e\u665a\u671f\u80be\u900f\u660e\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u7528\u4e8e\u542b\u94c2\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u665a\u671f\u5c3f\u8def\u4e0a\u76ae\u764c\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u963f\u6614\u66ff\u5c3c\u7528\u4e8e\u665a\u671f\u80be\u900f\u660e\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u9002\u5e94\u8bc1\u662f\u57fa\u4e8e\u5168\u7403\u2162\u671f<span>KEYNOTE-426<\/span>\u4e34\u5e8a\u7814\u7a76\u7684\u7ed3\u679c\u3002\u5e15\u535a\u5229\u73e0\u5355\u6297\u901a\u8fc7\u9759\u8109\u6ce8\u5c04\u7ed9\u836f<span>200mg<\/span>\u56fa\u5b9a\u5242\u91cf\uff0c\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c\u6bcf\u6b21\u6301\u7eed\u81f3\u5c11<span>30<\/span>\u5206\u949f\uff0c\u963f\u6614\u66ff\u5c3c<span>5mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u53e3\u670d\uff08\u90e8\u5206\u60a3\u8005\u8fdb\u884c\u4e86\u5242\u91cf\u6ef4\u5b9a\uff09\u3002\u5e15\u535a\u5229\u73e0\u5355\u6297\u7528\u4e8e\u4e0d\u8010\u53d7\u94c2\u7c7b\u5316\u7597\u7684\u665a\u671f\u5c3f\u8def\u4e0a\u76ae\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u9002\u5e94\u8bc1\u662f\u57fa\u4e8e\u2161\u671f\u5355\u81c2\u4e34\u5e8a\u7814\u7a76<span>KEYNOTE-052<\/span>\u7684\u7814\u7a76\u7ed3\u679c\uff0c\u8be5\u8054\u5408\u65b9\u6848\u5df2\u83b7\u5f97\u7f8e\u56fd<span>FDA<\/span>\u6279\u51c6\uff0c\u4f46\u76ee\u524d\u5c1a\u672a\u5f97\u5230\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u7684\u6279\u51c6\uff0c\u53ef\u5728\u4e0e\u60a3\u8005\u5145\u5206\u6c9f\u901a\u7684\u60c5\u51b5\u4e0b\u8003\u8651\u4f7f\u7528\u3002\u5e15\u535a\u5229\u73e0\u5355\u6297\u7528\u4e8e\u665a\u671f\u5c3f\u8def\u4e0a\u76ae\u764c\u7684\u4e8c\u7ebf\u6cbb\u7597\u9002\u5e94\u8bc1\u662f\u57fa\u4e8e\u5168\u7403\u2162\u671f\u4e34\u5e8a\u7814\u7a76<span>KEYNOTE-045<\/span>\u7684\u7814\u7a76\u7ed3\u679c\uff0c\u8be5\u6cbb\u7597\u65b9\u6848\u5df2\u83b7\u5f97\u7f8e\u56fd<span>FDA<\/span>\u6279\u51c6\uff0c\u4f46\u76ee\u524d\u5c1a\u672a\u5f97\u5230\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u7684\u6279\u51c6\uff0c\u53ef\u5728\u4e0e\u60a3\u8005\u5145\u5206\u6c9f\u901a\u7684\u60c5\u51b5\u4e0b\u8003\u8651\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u65e2\u5f80\u9776\u5411\u6cbb\u7597\u5931\u8d25\u7684\u665a\u671f\u80be\u900f\u660e\u7ec6\u80de\u764c\uff0c\u4e5f\u53ef\u4ee5\u8003\u8651\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u963f\u6614\u66ff\u5c3c\u7528\u4e8e\u4e8c\u4e09\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u4f7f\u7528\u672c\u54c1\u4e4b\u524d\u5e94\u907f\u514d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u514d\u75ab\u6291\u5236\u5242\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u836f\u7269\u53ef\u80fd\u4f1a\u5f71\u54cd\u672c\u54c1\u7684\u836f\u6548\u5b66\u6d3b\u6027\u53ca\u7597\u6548\u3002\u4f46\u5728\u672c\u54c1\u5f00\u59cb\u7ed9\u836f\u540e\uff0c\u53ef\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u514d\u75ab\u4ecb\u5bfc\u6027\u4e0d\u826f\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u505c\u836f\uff0c\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u5224\u65ad\u5176\u4e0e\u836f\u7269\u7684\u76f8\u5173\u6027\u3002\u5982\u53d1\u751f<span>4<\/span>\u7ea7\u6216\u590d\u53d1\u6027<span>3<\/span>\u7ea7\uff0c\u8003\u8651\u4e0e\u5e15\u535a\u5229\u73e0\u5355\u6297\u76f8\u5173\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u867d\u7136\u8fdb\u884c\u6cbb\u7597\u8c03\u6574\u4f46\u4ecd\u6301\u7eed\u5b58\u5728<span>2<\/span>\u7ea7\u6216<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u6c38\u4e45\u6027\u505c\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u3002\u6709\u5173\u963f\u6614\u66ff\u5c3c\u7684\u5177\u4f53\u7528\u6cd5\u8be6\u89c1\u963f\u6614\u66ff\u5c3c\u90e8\u5206\u7684\u4ecb\u7ecd\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8001\u5e74\u60a3\u8005\uff08\u2265<span>65<\/span>\u5c81\uff09\u4e0e\u5e74\u8f7b\u60a3\u8005\uff08\uff1c<span>65<\/span>\u5c81\uff09\u5728\u5b89\u5168\u6027\u6216\u6709\u6548\u6027\u4e0a\u672a\u51fa\u73b0\u603b\u4f53\u7684\u5dee\u5f02\uff0c\u65e0\u9700\u5728\u8fd9\u4e00\u4eba\u7fa4\u4e2d\u8fdb\u884c\u8c03\u6574\uff0c\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u6570\u636e\u6709\u9650\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u5c1a\u672a\u5728\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u8fdb\u884c\u672c\u54c1\u7684\u76f8\u5173\u7814\u7a76\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u53ef\u5f15\u8d77\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u3002\u56e0\u4e3a\u4e0d\u826f\u53cd\u5e94\u53ef\u80fd\u5728\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u671f\u95f4\u6216\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u505c\u6b62\u540e\u7684\u4efb\u4f55\u65f6\u95f4\u53d1\u751f\uff0c\u5e94\u6301\u7eed\u8fdb\u884c\u60a3\u8005\u76d1\u6d4b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u6682\u505c\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\uff0c\u5e76\u7ed9\u4e88\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u975e\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6027\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u3002\u5fc5\u8981\u65f6\u4e0e\u76f8\u5173\u9886\u57df\u5b66\u79d1\u8fdb\u884c\u591a\u5b66\u79d1\u8bca\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u60a3\u8005\u63a5\u53d7\u514d\u75ab\u6291\u5236\u5242\u91cf\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u6cbb\u7597\u671f\u95f4\uff0c\u4e0d\u53ef\u91cd\u65b0\u4f7f\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e5d\u3001\u66ff\u96f7\u5229\u73e0\u5355\u6297 <span>Tislelizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u7528\u4e8e<span>PD-L1<\/span>\u9ad8\u8868\u8fbe\u7684\u542b\u94c2\u5316\u7597\u5931\u8d25\u5305\u62ec\u65b0\u8f85\u52a9\u6216\u8f85\u52a9\u5316\u7597<span>12<\/span>\u4e2a\u6708\u5185\u8fdb\u5c55\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u8be5\u6309\u7167\u76f8\u5173\u75be\u75c5\u6307\u5357\uff0c\u6cbb\u7597\u524d\u505a\u57fa\u7ebf\u8bc4\u4f30\uff0c\u7279\u522b\u662f\u80bf\u7624\u7ec4\u7ec7\u7684<span>PD-L1<\/span>\u8868\u8fbe\u60c5\u51b5\u68c0\u6d4b\uff0c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u53cd\u5e94\u53ca\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u91c7\u7528\u9759\u8109\u8f93\u6ce8\u7684\u65b9\u5f0f\u7ed9\u836f\uff0c\u9759\u8109\u8f93\u6ce8\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>200mg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\uff0c\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u836f\u3002\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u5c1a\u65e0\u9488\u5bf9\u91cd\u5ea6\u809d\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u7814\u7a76\u6570\u636e\uff0c\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u4ee5\u53ca\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u53ca\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u7684\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u8c28\u614e\u4f7f\u7528\uff0c\u5982\u9700\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u54fa\u4e73\u671f\u5987\u5973\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u53ca\u672b\u6b21\u7ed9\u836f\u540e\u81f3\u5c11<span>5<\/span>\u4e2a\u6708\u5185\u505c\u6b62\u54fa\u4e73\u3002\u80b2\u9f84\u671f\u5987\u5973\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u671f\u95f4\uff0c\u4ee5\u53ca\u6700\u540e\u4e00\u6b21\u672c\u54c1\u7ed9\u836f\u540e\u81f3\u5c11<span>5<\/span>\u4e2a\u6708\u5185\u5e94\u91c7\u7528\u6709\u6548\u907f\u5b55\u63aa\u65bd\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56e0\u53ef\u80fd\u5e72\u6270\u672c\u54c1\u836f\u6548\u5b66\u6d3b\u6027\uff0c\u5e94\u907f\u514d\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002\u4f46\u662f\u5982\u679c\u4e3a\u4e86\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u540e\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u3001\u7279\u745e\u666e\u5229\u5355\u6297 <span>Toripalimab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c<\/span><\/b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\uff1a\u6ce8\u5c04\u6db2\uff1a<span>80mg<\/span>\uff08<span>2ml<\/span>\uff09<span>\/<\/span>\u74f6\u3001<span>240mg<\/span>\uff08<span>6ml<\/span>\uff09<span>\/<\/span>\u74f6<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u7528\u4e8e\u542b\u94c2\u5316\u7597\u5931\u8d25\u5305\u62ec\u65b0\u8f85\u52a9\u6216\u8f85\u52a9\u5316\u7597<span>12<\/span>\u4e2a\u6708\u5185\u8fdb\u5c55\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7279\u745e\u666e\u5229\u5355\u6297\u63a8\u8350\u5242\u91cf\u4e3a<span>3mg\/kg<\/span>\u3002\u9759\u8109\u8f93\u6ce8\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7279\u745e\u666e\u5229\u5355\u6297\u5728\u4e2d\u91cd\u5ea6\u809d\u80be\u529f\u80fd\u635f\u4f24\u4e2d\u4f7f\u7528\u7684\u5b89\u5168\u6027\u53ca\u6709\u6548\u6027\u5c1a\u672a\u5efa\u7acb\uff0c\u4e0d\u63a8\u8350\u7528\u4e8e\u4e2d\u91cd\u5ea6\u809d\u80be\u529f\u80fd\u635f\u4f24\u7684\u60a3\u8005\u3002\u8f7b\u5ea6\u809d\u80be\u529f\u80fd\u635f\u4f24\u7684\u60a3\u8005\u5e94\u5728\u533b\u751f\u6307\u5bfc\u4e0b\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8001\u5e74\u60a3\u8005\uff08\u2265<span>65<\/span>\u5c81\uff09\u5efa\u8bae\u5728\u533b\u751f\u7684\u6307\u5bfc\u4e0b\u4f7f\u7528\uff0c\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\uff1b\u5c1a\u672a\u5efa\u7acb<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u53ca\u9752\u5c11\u5e74\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7279\u745e\u666e\u5229\u5355\u6297\u9996\u6b21\u9759\u8109\u8f93\u6ce8\u65f6\u95f4\u81f3\u5c11<span>60<\/span>\u5206\u949f\uff0c\u5982\u679c\u7b2c\u4e00\u6b21\u8f93\u6ce8\u8010\u53d7\u826f\u597d\uff0c\u5219\u7b2c\u4e8c\u6b21\u8f93\u6ce8\u65f6\u95f4\u53ef\u4ee5\u7f29\u77ed\u81f3<span>30<\/span>\u5206\u949f\uff0c\u5982\u679c\u60a3\u8005\u5bf9<span>30<\/span>\u5206\u949f\u7684\u8f93\u6ce8\u4e5f\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u540e\u7eed\u6240\u6709\u8f93\u6ce8\u5747\u53ef\u5728<span>30<\/span>\u5206\u949f\u5b8c\u6210\uff0c\u4e0d\u5f97\u91c7\u7528\u9759\u8109\u63a8\u6ce8\u6216\u5355\u6b21\u5feb\u901f\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u53ef\u53d1\u751f\u5728\u7279\u745e\u666e\u5229\u5355\u6297\u6cbb\u7597\u671f\u95f4\u53ca\u505c\u836f\u4ee5\u540e\uff0c\u53ef\u80fd\u7d2f\u53ca\u4efb\u4f55\u7ec4\u7ec7\u5668\u5b98\u3002\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u53ca\u6392\u9664\u5176\u4ed6\u539f\u56e0\u3002\u5927\u591a\u6570\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u662f\u53ef\u9006\u7684\uff0c\u5e76\u4e14\u53ef\u901a\u8fc7\u4e2d\u65ad\u7279\u745e\u666e\u5229\u5355\u6297\u3001\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u548c<span>\/<\/span>\u6216\u652f\u6301\u6cbb\u7597\u6765\u5904\u7406\u3002\u5bf9\u4e8e\u5927\u90e8\u5206<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u53ca\u67d0\u4e9b\u7279\u5b9a\u7684<span>2<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u9700\u6682\u505c\u7ed9\u836f\uff0c\u5bf9\u4e8e<span>4<\/span>\u7ea7\u53ca\u67d0\u4e9b\u7279\u5b9a\u7684<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u9700\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7279\u745e\u666e\u5229\u5355\u6297\u4e0d\u7ecf<span>CYP450<\/span>\u9176\u6216\u5176\u4ed6\u836f\u7269\u4ee3\u8c22\u9176\u4ee3\u8c22\uff0c\u56e0\u6b64\u5408\u5e76\u4f7f\u7528\u7684\u836f\u7269\u5bf9\u8fd9\u4e9b\u9176\u7684\u6291\u5236\u6216\u8bf1\u5bfc\u4f5c\u7528\u9884\u671f\u4e0d\u4f1a\u5f71\u54cd\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u4e00\u3001\u5965\u62c9\u5e15\u5229<span> Olaparib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>100mg<\/span>\u3001<span>150mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u643a\u5e26\u80da\u7cfb\u6216\u4f53\u7ec6\u80de<span>BRCA<\/span>\u7a81\u53d8\u4e14\u65e2\u5f80\u6cbb\u7597\uff08\u5305\u62ec\u4e00\u79cd\u65b0\u578b\u5185\u5206\u6ccc\u836f\u7269\uff09\u5931\u8d25\u7684\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u6210\u4eba\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5965\u62c9\u5e15\u5229\u7528\u4e8e\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u4e4b\u524d\uff0c\u5fc5\u987b\u91c7\u7528\u7ecf\u56fd\u5bb6\u836f\u76d1\u5c40\u6279\u51c6\u6216\u5176\u4ed6\u7ecf\u9a8c\u8bc1\u7684\u68c0\u6d4b\u65b9\u6cd5\uff0c\u786e\u8ba4\u60a3\u8005\u5b58\u5728\u80da\u7cfb\u548c<span>\/<\/span>\u6216\u4f53\u7ec6\u80de<span>BRCA1\/2<\/span>\u7a81\u53d8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a<span>300mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u5373\u6bcf\u5929\u603b\u5242\u91cf\u4e3a<span>600mg<\/span>\uff0c\u7528\u81f3\u75be\u75c5\u53d1\u751f\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.BRCA1\/2<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u7597\u7a0b\uff1a\u5efa\u8bae\u6301\u7eed\u6cbb\u7597\u76f4\u5230\u73b0\u6709\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u80fd\u8010\u53d7\u7684\u6bd2\u6027\u3002\u5bf9\u4e8e\u672a\u63a5\u53d7\u624b\u672f\u53bb\u52bf\u7684\u60a3\u8005\uff0c\u5e94\u5728\u6cbb\u7597\u671f\u95f4\u7ee7\u7eed\u4f7f\u7528\u4fc3\u9ec4\u4f53\u751f\u6210\u6fc0\u7d20\u91ca\u653e\u6fc0\u7d20\u7c7b\u4f3c\u7269\u8fdb\u884c\u836f\u7269\u53bb\u52bf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u6574\u7247\u541e\u670d\uff0c\u4e0d\u5e94\u5480\u56bc\u3001\u538b\u788e\u3001\u6eb6\u89e3\u6216\u63b0\u65ad\u836f\u7247\u3002\u5728\u8fdb\u9910\u6216\u7a7a\u8179\u65f6\u5747\u53ef\u670d\u7528\u3002\u5982\u679c\u60a3\u8005\u6f0f\u670d\u4e00\u5242\u836f\u7269\uff0c\u65e0\u9700\u8865\u670d\uff0c\u4ecd\u6309\u8ba1\u5212\u65f6\u95f4\u6b63\u5e38\u670d\u7528\u4e0b\u4e00\u5242\u91cf\uff0c\u5e76\u4e0d\u5f71\u54cd\u6574\u4f53\u7597\u6548\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5965\u62c9\u5e15\u5229\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u2265<span>20%<\/span>\uff09\u662f\uff1a\u8d2b\u8840\u3001\u6076\u5fc3\u3001\u75b2\u4e4f\uff08\u5305\u62ec\u4e4f\u529b\uff09\u3001\u5455\u5410\u3001\u8179\u6cfb\u3001\u5473\u89c9\u969c\u788d\u548c\u6d88\u5316\u4e0d\u826f\u3002\u6700\u5e38\u89c1\u7684\u751f\u5316\u68c0\u67e5\u5f02\u5e38\uff08\u2265<span>25%<\/span>\uff09\u662f\uff1a\u808c\u9150\u589e\u52a0\u3001\u7ea2\u7ec6\u80de\u5747\u6570\u4f53\u79ef\u5347\u9ad8\u3001\u8840\u7ea2\u86cb\u767d\u51cf\u4f4e\u3001\u6dcb\u5df4\u7ec6\u80de\u51cf\u4f4e\uff0c\u7edd\u5bf9\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u51cf\u4f4e\u3001\u8840\u5c0f\u677f\u51cf\u4f4e\u3002\u4e3a\u5904\u7406\u4e0d\u826f\u4e8b\u4ef6\uff0c\u6bd4\u5982\u8d2b\u8840\u3001\u6076\u5fc3\uff0c\u4e4f\u529b\u7b49\uff0c\u53ef\u8003\u8651\u4e2d\u65ad\u6cbb\u7597\u6216\u51cf\u91cf\u3002\u60a3\u8005\u5e94\u5728\u65e2\u5f80\u6297\u80bf\u7624\u6cbb\u7597\u5f15\u8d77\u7684\u8840\u6db2\u5b66\u6bd2\u6027\u6062\u590d\u4e4b\u540e\uff08\u8840\u7ea2\u86cb\u767d\u3001\u8840\u5c0f\u677f\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u6c34\u5e73\u5e94\u6062\u590d\u81f3\u2264<span>CTCAE l<\/span>\u7ea7\uff09\uff0c\u624d\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u3002\u5efa\u8bae\u5728\u57fa\u7ebf\u4ee5\u53ca\u6cbb\u7597\u7684\u524d<span>12<\/span>\u4e2a\u6708\u6bcf\u6708\u76d1\u6d4b\u5168\u8840\u7ec6\u80de\u8ba1\u6570\uff0c\u7136\u540e\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u671f\u95f4\u4efb\u4f55\u4e34\u5e8a\u663e\u8457\u53d8\u5316\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u9700\u8981\u51cf\u91cf\uff0c\u63a8\u8350\u5242\u91cf\u51cf\u81f3<span>250mg\/<\/span>\u6b21\uff08<span>1<\/span>\u7247<span>150mg<\/span>\u7247\u5242\uff0c<span>1<\/span>\u7247<span>100mg<\/span>\u7247\u5242\uff09\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u5373\u6bcf\u5929\u603b\u5242\u91cf\u4e3a<span>500mg<\/span>\u3002\u5982\u679c\u9700\u8981\u8fdb\u4e00\u6b65\u51cf\u91cf\uff0c\u5219\u63a8\u8350\u5242\u91cf\u51cf\u81f3<span>200mg\/<\/span>\u6b21\uff08<span>2<\/span>\u7247<span>100mg<\/span>\u7247\u5242\uff09\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u5373\u6bcf\u5929\u603b\u5242\u91cf\u4e3a<span>400mg<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u63a8\u8350\u672c\u54c1\u4e0e\u5f3a\u6548\u6216\u4e2d\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\u5408\u5e76\u4f7f\u7528\uff0c\u5982\u679c\u5fc5\u987b\u5408\u5e76\u4f7f\u7528\u5f3a\u6548\u6216\u4e2d\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\uff0c\u63a8\u8350\u5c06\u672c\u54c1\u5242\u91cf\u51cf\u81f3<span>100mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u5982\u679c\u5fc5\u987b\u5408\u5e76\u4f7f\u7528\u4e2d\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\uff0c\u63a8\u8350\u5c06\u672c\u54c1\u5242\u91cf\u51cf\u81f3<span>150mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p><b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><br \/>\n<\/span><\/b> <\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e73\u817a\u764c\u7528\u836f<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e00\u3001\u66f2\u59a5\u73e0\u5355\u6297<span> Trastuzumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u5242\uff1a<span>440mg<\/span>\uff08<span>20ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u590d\u53d1\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff1a\u672c\u54c1\u9002\u7528\u4e8e<span>HER2<\/span>\u9633\u6027\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff0c\u5355\u836f\u7528\u4e8e\u5df2\u63a5\u53d7\u8fc7\u591a\u4e2a\u5316\u7597\u65b9\u6848\u7684\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff1b\u4e0e\u7d2b\u6749\u9187\u6216\u591a\u897f\u4ed6\u8d5b\u7b49\u5316\u7597\u836f\u7269\u8054\u5408\uff0c\u7528\u4e8e\u672a\u63a5\u53d7\u5316\u7597\u7684\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e73\u817a\u764c\u8f85\u52a9\u6cbb\u7597\uff1a\u672c\u54c1\u9002\u7528\u4e8e\u80bf\u7624\u76f4\u5f84\uff1e<span>0.5cm<\/span>\u7684<span>HER2<\/span>\u9633\u6027\u53ef\u624b\u672f\u4e73\u817a\u764c\u7684\u8f85\u52a9\u6cbb\u7597\uff1b\u5bf9\u80bf\u7624\u76f4\u5f84\uff1c<span>0.5cm<\/span>\u6d78\u6da6\u6027\u4e73\u817a\u764c\uff0c\u9700\u8981\u7ed3\u5408\u5176\u4ed6\u56e0\u7d20\u8003\u8651\u662f\u5426\u4f7f\u7528\u3002\u66f2\u59a5\u73e0\u5355\u6297\u4e00\u822c\u4e0d\u4e0e\u84bd\u73af\u7c7b\u836f\u7269\u8054\u5408\u4f7f\u7528\uff0c\u4f46\u53ef\u5e8f\u8d2f\u4f7f\u7528\uff1b\u53ef\u4e0e\u7d2b\u6749\u7c7b\u53ca\u5176\u4ed6\uff08\u73af\u78f7\u9170\u80fa\u3001\u5361\u94c2\u7b49\uff09\u5316\u7597\u836f\u7269\u5408\u7528\uff0c\u8fd8\u53ef\u4e0e\u653e\u7597\u3001\u8f85\u52a9\u5185\u5206\u6ccc\u6cbb\u7597\u540c\u65f6\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e73\u817a\u764c\u65b0\u8f85\u52a9\u6cbb\u7597\uff1a\u4e0e\u5316\u7597\u8054\u5408\u8fdb\u884c\u65b0\u8f85\u52a9\u6cbb\u7597\uff0c\u7ee7\u4ee5\u8f85\u52a9\u6cbb\u7597\uff0c\u7528\u4e8e\u5c40\u90e8\u665a\u671f\uff08\u5305\u62ec\u708e\u6027\uff09\u7684<span>HER2<\/span>\u9633\u6027\u4e73\u817a\u764c\u3002\u672f\u540e\u7ee7\u7eed\u4f7f\u7528\u66f2\u59a5\u73e0\u5355\u6297\u603b\u7597\u7a0b\u4e3a<span>1<\/span>\u5e74\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5728\u63a5\u53d7\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u524d\uff0c\u5e94\u5728\u6709\u8d44\u8d28\u7684\u75c5\u7406\u5b9e\u9a8c\u5ba4\u8fdb\u884c<span>HER2<\/span>\u68c0\u6d4b\uff0c<span>HER2<\/span>\u9633\u6027\u60a3\u8005\u65b9\u53ef\u5e94\u7528\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e0e\u84bd\u73af\u7c7b\u836f\u7269\u540c\u671f\u5e94\u7528\u987b\u614e\u91cd\uff0c\u53ef\u80fd\u589e\u52a0\u5fc3\u810f\u6bd2\u6027\uff0c\u4e25\u91cd\u8005\u4f1a\u53d1\u751f\u5fc3\u529b\u8870\u7aed\uff0c\u5efa\u8bae\u5e8f\u8d2f\u4f7f\u7528\u6216\u5206\u522b\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u8981\u5bf9\u65e2\u5f80\u53f2\u3001\u4f53\u683c\u68c0\u67e5\u3001\u5fc3\u7535\u56fe\u3001\u8d85\u58f0\u5fc3\u52a8\u56fe<span>LVEF<\/span>\u57fa\u7ebf\u8bc4\u4f30\u540e\uff0c\u518d\u5f00\u59cb\u5e94\u7528\u66f2\u59a5\u73e0\u5355\u6297\uff0c\u4f7f\u7528\u671f\u95f4\u5e94\u6bcf<span>3<\/span>\u4e2a\u6708\u76d1\u6d4b<span>LVEF<\/span>\u3002\u82e5\u60a3\u8005\u6709\u65e0\u75c7\u72b6\u6027\u5fc3\u529f\u80fd\u4e0d\u5168\uff0c\u76d1\u6d4b\u9891\u7387\u5e94\u66f4\u9ad8\u3002\u51fa\u73b0\u4e0b\u5217\u60c5\u51b5\u65f6\uff1a\u6cbb\u7597\u4e2d\u82e5\u51fa\u73b0<span>LVEF<\/span>\uff1c<span>50%<\/span>\u6216\u4f4e\u4e8e\u6cbb\u7597\u524d<span>16%<\/span>\u4ee5\u4e0a\uff0c\u5e94\u6682\u505c\u6cbb\u7597\uff0c\u5e76\u8ddf\u8e2a\u76d1\u6d4b<span>LVEF<\/span>\u52a8\u6001\u53d8\u5316\uff0c\u76f4\u81f3\u6062\u590d\u5230<span>50%<\/span>\u4ee5\u4e0a\u65b9\u53ef\u7ee7\u7eed\u7528\u836f\u3002<span>LVEF<\/span>\u6301\u7eed\u4e0b\u964d\uff08\u5927\u4e8e<span>8<\/span>\u5468\uff09\uff0c\u6216\u8005\u4e09\u6b21\u4ee5\u4e0a\u56e0\u5fc3\u810f\u6bd2\u6027\u800c\u505c\u6b62\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\uff0c\u5e94\u6c38\u4e45\u505c\u7528\u66f2\u59a5\u73e0\u5355\u6297\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u8bc1\u5b9e\uff0c<span>HER2<\/span>\u9633\u6027\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\uff0c\u5728\u5176\u4ed6\u5316\u7597\u836f\u7269\u6216\u5185\u5206\u6ccc\u836f\u7269\u6cbb\u7597\u65f6\uff0c\u8054\u5408\u66f2\u59a5\u73e0\u5355\u6297\u53ef\u8fdb\u4e00\u6b65\u589e\u52a0\u4e34\u5e8a\u83b7\u76ca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u540e\u8fdb\u5c55\u7684<span>HER2<\/span>\u9633\u6027\u4e73\u817a\u764c\uff0c\u4e5f\u6709\u8bc1\u636e\u8bc1\u5b9e\u7ee7\u7eed\u4f7f\u7528\u66f2\u59a5\u73e0\u5355\u6297\u7684\u4e34\u5e8a\u83b7\u76ca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u6bcf\u5468\u7ed9\u836f\u65b9\u6848\u521d\u6b21\u8d1f\u8377\u5242\u91cf\uff1a\u5efa\u8bae\u672c\u54c1\u7684\u521d\u6b21\u8d1f\u8377\u91cf\u4e3a<span>4mg\/kg<\/span>\u3002\u9759\u8109\u8f93\u6ce8<span>90<\/span>\u5206\u949f\u4ee5\u4e0a\u3002\u7ef4\u6301\u5242\u91cf\uff1a\u5efa\u8bae\u672c\u54c1\u6bcf\u5468\u7528\u91cf\u4e3a<span>2mg\/kg<\/span>\u3002\u5982\u521d\u6b21\u8d1f\u8377\u91cf\u53ef\u8010\u53d7\uff0c\u5219\u6b64\u5242\u91cf\u53ef\u9759\u8109\u8f93\u6ce8<span>30<\/span>\u5206\u949f\u3002<span>3<\/span>\u5468\u7ed9\u836f\u65b9\u6848\u521d\u59cb\u8d1f\u8377\u5242\u91cf\u4e3a<span>8mg\/kg<\/span>\uff0c\u968f\u540e<span>6mg\/kg<\/span>\u6bcf\u4e09\u5468\u7ed9\u836f\u4e00\u6b21\u3002\u4e14\u91cd\u590d<span>6mg\/kg<\/span>\u6bcf\u4e09\u5468\u7ed9\u836f\u4e00\u6b21\u65f6\u8f93\u6ce8\u65f6\u95f4\u7ea6\u4e3a<span>90<\/span>\u5206\u949f\u3002\u5982\u679c\u60a3\u8005\u5728\u9996\u6b21\u8f93\u6ce8\u65f6\u8010\u53d7\u6027\u826f\u597d\uff0c\u540e\u7eed\u8f93\u6ce8\u53ef\u6539\u4e3a<span>30<\/span>\u5206\u949f\u3002\u914d\u7f6e\u540e\u7684\u6eb6\u6db2\u7a00\u91ca\u4e8e<span>250ml<\/span>\u7684<span>0.9%<\/span>\u6c2f\u5316\u94a0\u4e2d\uff0c\u4e0d\u53ef\u4f7f\u7528<span>5%<\/span>\u7684\u8461\u8404\u7cd6\uff08\u53ef\u4f7f\u86cb\u767d\u805a\u96c6\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u7597\u7a0b\uff1a\u4e73\u817a\u764c\u60a3\u8005\u672f\u540e\u4f7f\u7528\u66f2\u59a5\u73e0\u5355\u6297\u8f85\u52a9\u6cbb\u7597\u65f6\u95f4\u4e3a<span>1<\/span>\u5e74\uff0c\u4e0d\u5efa\u8bae\u5ef6\u957f\u6cbb\u7597\u65f6\u95f4\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u6069\u7f8e\u66f2\u59a5\u73e0\u5355\u6297<span> Trastuzumab Emtansine<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9488\u5242\uff1a<span>100mg\/<\/span>\u74f6\u3001<span>160mg\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5355\u836f\u9002\u7528\u4e8e\u63a5\u53d7\u4e86\u7d2b\u6749\u7c7b\u8054\u5408\u66f2\u59a5\u73e0\u5355\u6297\u4e3a\u57fa\u7840\u7684\u65b0\u8f85\u52a9\u6cbb\u7597\u540e\u4ecd\u6b8b\u5b58\u4fb5\u88ad\u6027\u75c5\u7076\u7684<span>HER2<\/span>\u9633\u6027\u65e9\u671f\u4e73\u817a\u764c\u60a3\u8005\u7684\u8f85\u52a9\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6069\u7f8e\u66f2\u59a5\u73e0\u5355\u6297\uff08<span>T-DM1<\/span>\uff09\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\u4e3a\u4e0d\u540c\u836f\u7269\uff0c\u7981\u6b62\u5728\u4e34\u5e8a\u5e94\u7528\u4e2d\u8fdb\u884c\u66ff\u6362\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a5\u53d7<span>T-DM1<\/span>\u8f85\u52a9\u6cbb\u7597\u7684\u60a3\u8005\u5e94\u7b26\u5408\u4ee5\u4e0b\u8981\u6c42\uff1a\uff08<span>1<\/span>\uff09\u5e94\u5728\u6709\u8d44\u8d28\u7684\u75c5\u7406\u5b9e\u9a8c\u5ba4\u901a\u8fc7<span>HER2<\/span>\u68c0\u6d4b\u786e\u8ba4\u4e3a<span>HER2<\/span>\u9633\u6027\u3002\uff08<span>2<\/span>\uff09\u5b8c\u6210\u4ee5\u66f2\u59a5\u73e0\u5355\u6297\uff08<span>H<\/span>\uff09\u548c\u7d2b\u6749\u7c7b\u4e3a\u57fa\u7840\u7684\u65b0\u8f85\u52a9\u6cbb\u7597\u65b9\u6848\u3002\uff08<span>3<\/span>\uff09\u65b0\u8f85\u52a9\u6cbb\u7597\u540e\u7684\u75c5\u7406\u8bc4\u4f30\u7ed3\u679c\u672a\u80fd\u8fbe\u5230\u75c5\u7406\u5b66\u5b8c\u5168\u7f13\u89e3\u3002\u75c5\u7406\u5b66\u5b8c\u5168\u7f13\u89e3\uff08<span>pCR<\/span>\uff09\u5b9a\u4e49\u4e3a\u4e73\u817a\u539f\u53d1\u7076\u65e0\u6d78\u6da6\u6027\u764c\u4e14\u533a\u57df\u6dcb\u5df4\u7ed3\u9634\u6027\uff0c\u5373<span>ypT0\/Tis ypN0<\/span>\u3002\u65b0\u8f85\u52a9\u6cbb\u7597\u540e\u4ec5\u6b8b\u4f59\u4e73\u817a\u8109\u7ba1\u5185\u80bf\u7624\u6216\u4ec5\u6dcb\u5df4\u7ed3\u5185\u6b8b\u4f59<span>ITC<\/span>\u5747\u4e0d\u80fd\u8bca\u65ad<span>pCR<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.T-DM1<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>3.6mg\/kg<\/span>\uff0c\u91c7\u7528\u9759\u8109\u8f93\u6ce8\u7ed9\u836f\uff0c\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff08<span>21<\/span>\u5929\u4e3a\u4e00\u4e2a\u5468\u671f\uff09\u3002\u65e9\u671f\u4e73\u817a\u764c\u60a3\u8005\u5e94\u63a5\u53d7\u5171<span>14<\/span>\u4e2a\u5468\u671f\u7684\u6cbb\u7597\uff0c\u9664\u975e\u75be\u75c5\u590d\u53d1\u6216\u51fa\u73b0\u65e0\u6cd5\u63a7\u5236\u7684\u6bd2\u6027\u3002\u53d1\u751f\u4e0d\u826f\u53cd\u5e94\u65f6\u5e94\u6839\u636e\u8bf4\u660e\u4e66\u53ca\u65f6\u8c03\u6574\u5242\u91cf\uff0c\u5242\u91cf\u964d\u4f4e\u65b9\u6848\u5982\u4e0b\u8868\u3002\u964d\u4f4e\u5242\u91cf\u540e\uff0c\u4e0d\u5e94\u518d\u589e\u52a0<span>T-DM1<\/span>\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<table class=\"MsoTableGrid\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"100%\" style=\"width:100.0%;border-collapse:collapse;border:none;\">\n<tbody>\n<tr>\n<td width=\"100%\" colspan=\"2\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8868<span>5<\/span>&emsp;\u6069\u7f8e\u66f2\u59a5\u73e0\u5355\u6297\u5242\u91cf\u964d\u4f4e\u65b9\u6848<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"50%\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u964d\u4f4e\u65b9\u6848<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"50%\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u6c34\u5e73<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"50%\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d77\u59cb\u5242\u91cf<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"50%\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.6mg\/kg<\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"50%\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7b2c\u4e00\u6b21\u964d\u4f4e\u5242\u91cf<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"50%\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3mg\/kg<\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"50%\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7b2c\u4e8c\u6b21\u964d\u4f4e\u5242\u91cf<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"50%\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.4mg\/kg<\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"50%\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9700\u8981\u8fdb\u4e00\u6b65\u964d\u4f4e\u5242\u91cf<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"50%\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ec8\u6b62\u6cbb\u7597<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u8981\u5bf9\u65e2\u5f80\u53f2\u3001\u4f53\u683c\u68c0\u67e5\u3001\u5fc3\u7535\u56fe\u3001\u8d85\u58f0\u5fc3\u52a8\u56fe<span>LVEF<\/span>\u57fa\u7ebf\u8bc4\u4f30\u540e\uff0c\u518d\u5f00\u59cb\u5e94\u7528<span>T-DM1<\/span>\uff0c\u4f7f\u7528\u671f\u95f4\u5e94\u6bcf<span>3<\/span>\u4e2a\u6708\u76d1\u6d4b<span>LVEF<\/span>\u3002\u82e5\u60a3\u8005\u6709\u65e0\u75c7\u72b6\u6027\u5fc3\u529f\u80fd\u4e0d\u5168\uff0c\u76d1\u6d4b\u9891\u7387\u5e94\u66f4\u9ad8\u3002\u51fa\u73b0\u4e0b\u5217\u60c5\u51b5\u65f6\uff1a\uff08<span>1<\/span>\uff09<span>LVEF<\/span>\uff1c<span>45%<\/span>\u5e94\u6682\u505c\u6cbb\u7597\uff0c<span>3<\/span>\u5468\u5185\u91cd\u590d\u8bc4\u4f30<span>LVEF<\/span>\u3002\u5982\u679c\u786e\u8ba4<span>LVEF<\/span>\uff1c<span>45%<\/span>\uff0c\u5e94\u7ec8\u6b62\u6cbb\u7597\u3002\uff08<span>2<\/span>\uff09<span>LVEF<\/span>\u4e3a<span>45%<\/span>\u81f3\uff1c<span>50%<\/span>\uff0c\u4e14\u76f8\u5bf9\u57fa\u7ebf\u4e0b\u964d\u2265<span>10%<\/span>\uff0c\u5e94\u6682\u505c\u6cbb\u7597\uff0c\u5e76\u5728<span>3<\/span>\u5468\u5185\u91cd\u590d\u8bc4\u4f30<span>LVEF<\/span>\u3002\u5982\u679c<span>LVEF<\/span>\u4ecd\u4e3a\uff1c<span>50%<\/span>\uff0c\u5e76\u4e14\u76f8\u5bf9\u57fa\u7ebf\u672a\u6062\u590d\u81f3\uff1c<span>10%<\/span>\uff0c\u5e94\u7ec8\u6b62\u6cbb\u7597\u3002\uff08<span>3<\/span>\uff09<span>LVEF<\/span>\u4e3a<span>45%<\/span>\u81f3\uff1c<span>50%<\/span>\uff0c\u76f8\u5bf9\u57fa\u7ebf\u4e0b\u964d\uff1c<span>10%<\/span>\uff0c\u53ef\u7ee7\u7eed\u6cbb\u7597\uff0c\u5e76\u5728<span>3<\/span>\u5468\u5185\u91cd\u590d\u8bc4\u4f30<span>LVEF<\/span>\u3002\uff08<span>4<\/span>\uff09<span>LVEF<\/span>\u2265<span>50%<\/span>\uff0c\u53ef\u7ee7\u7eed\u8fdb\u884c\u6cbb\u7597\u3002\uff08<span>5<\/span>\uff09\u75c7\u72b6\u6027\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\uff0c<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u5de6\u5fc3\u5ba4\u6536\u7f29\u529f\u80fd\u969c\u788d\u6216<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u5fc3\u529b\u8870\u7aed\uff0c\u6216<span>2<\/span>\u7ea7\u5fc3\u529b\u8870\u7aed\u4f34\u6709<span>LVEF<\/span>\uff1c<span>45%<\/span>\uff0c\u5e94\u7ec8\u6b62\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u5728\u6bcf\u6b21<span>T-DM1<\/span>\u7ed9\u836f\u4e4b\u524d\u76d1\u6d4b\u8840\u5c0f\u677f\u8ba1\u6570\uff1a\uff08<span>1<\/span>\uff09\u5982\u679c\u8ba1\u5212\u6cbb\u7597\u65e5\u65f6\u4e3a<span>2<\/span>\uff5e<span>3<\/span>\u7ea7\uff08<span>25<\/span>\uff5e<span>75<\/span>\uff09\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff0c\u5219\u5e94\u5ef6\u8fdf\u81f3\u8840\u5c0f\u677f\u8ba1\u6570\u6062\u590d\u81f3\u2264<span>1<\/span>\u7ea7\uff08\u2265<span>75<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff09\u540e\u4ee5\u76f8\u540c\u5242\u91cf\u6c34\u5e73\u8fdb\u884c\u6cbb\u7597\u3002\u5982\u679c\u60a3\u8005\u56e0\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u9700\u5ef6\u8fdf\u4e24\u6b21\u7ed9\u836f\uff0c\u5e94\u8003\u8651\u964d\u4f4e\u4e00\u4e2a\u5242\u91cf\u6c34\u5e73\u8fdb\u884c\u6cbb\u7597\u3002\uff08<span>2<\/span>\uff09\u5982\u679c\u8840\u5c0f\u677f\u964d\u4f4e\u8fbe\u5230<span>4<\/span>\u7ea7\uff08\uff1c<span>25<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff09\uff0c\u5219\u5e94\u5ef6\u8fdf\u81f3\u8840\u5c0f\u677f\u8ba1\u6570\u6062\u590d\u81f3\u2264<span>1<\/span>\u7ea7\uff08\u2265<span>75<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff09\u540e\u964d\u4f4e\u4e00\u4e2a\u5242\u91cf\u6c34\u5e73\u8fdb\u884c\u6cbb\u7597\u3002\uff08<span>3<\/span>\uff09\u5bf9\u4e8e\u51fa\u73b0\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\uff08\u8840\u5c0f\u677f\u8ba1\u6570\uff1c<span>100<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff09\u7684\u60a3\u8005\u548c\u6b63\u5728\u63a5\u53d7\u6297\u51dd\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u5728\u672c\u54c1\u6cbb\u7597\u671f\u95f4\uff0c\u5e94\u8be5\u5bf9\u5176\u8fdb\u884c\u5bc6\u5207\u76d1\u6d4b\u3002\uff08<span>4<\/span>\uff09\u7edd\u5927\u591a\u6570\u8840\u5c0f\u677f\u51cf\u5c11\u53ef\u4ee5\u6839\u636e\u8bf4\u660e\u4e66\u8fdb\u884c\u6682\u505c\u6216\u51cf\u91cf\u53ca\u505c\u836f\u5904\u7406\u540e\u6062\u590d\u3002\u7ecf\u5e38\u89c4\u5347\u8840\u5c0f\u677f\u6cbb\u7597\u540e\u6548\u679c\u4e0d\u4f73\u65f6\uff0c\u5e94\u5c3d\u65e9\u8bf7\u8840\u6db2\u79d1\u4e13\u79d1\u533b\u5e08\u4f1a\u8bca\uff0c\u5fc5\u8981\u65f6\u7ed9\u4e88\u9488\u5bf9\u6027\u7684\u68c0\u67e5\u5982\u9aa8\u9ad3\u7a7f\u523a\u3001\u8840\u5c0f\u677f\u751f\u6210\u7d20\u6297\u4f53\u3001\u8840\u5c0f\u677f\u6297\u4f53\u68c0\u6d4b\u7b49\uff0c\u660e\u786e\u53ef\u80fd\u7684\u75c5\u56e0\u540e\u7ed9\u4e88\u5bf9\u75c7\u5904\u7406\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e24\u9879\u56fd\u9645\u591a\u4e2d\u5fc3\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u63d0\u793a\uff1a<span>T-DM1<\/span>\u7528\u4e8e\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u5931\u8d25\u7684<span>HER2<\/span>\u9633\u6027\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\uff0c\u5bf9\u6bd4\u62c9\u5e15\u66ff\u5c3c\u8054\u5408\u5361\u57f9\u4ed6\u6ee8\u548c\u533b\u5e08\u9009\u62e9\u7684\u6cbb\u7597\u65b9\u6848\u5747\u53ef\u663e\u8457\u5ef6\u957f\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u548c\u603b\u751f\u5b58\u671f\u3002<span>T-DM1<\/span>\u53ef\u4f5c\u4e3a<span>HER2<\/span>\u9633\u6027\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\u4e8c\u7ebf\u53ca\u540e\u7ebf\u7684\u6cbb\u7597\u9009\u62e9\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e09\u3001\u5e15\u59a5\u73e0\u5355\u6297<span> Pertuzumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>420mg<\/span>\uff08<span>14ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e73\u817a\u764c\u8f85\u52a9\u6cbb\u7597\uff1a\u672c\u54c1\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\u548c\u5316\u7597\u8054\u5408\uff0c\u7528\u4e8e\u9ad8\u590d\u53d1\u98ce\u9669\u7684<span>HER2<\/span>\u9633\u6027\u65e9\u671f\u4e73\u817a\u764c\u60a3\u8005\u7684\u8f85\u52a9\u6cbb\u7597\u3002\u5e15\u59a5\u73e0\u5355\u6297\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\u8054\u5408\uff0c\u8fd8\u53ef\u4e0e\u8f85\u52a9\u5185\u5206\u6ccc\u6cbb\u7597\u540c\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e73\u817a\u764c\u65b0\u8f85\u52a9\u6cbb\u7597\uff1a\u672c\u54c1\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\u548c\u5316\u7597\u8054\u5408\uff0c\u7528\u4e8e<span>HER2<\/span>\u9633\u6027\u3001\u5c40\u90e8\u665a\u671f\u3001\u708e\u6027\u6216\u65e9\u671f\u4e73\u817a\u764c\u60a3\u8005\uff08\u80bf\u7624\u76f4\u5f84\uff1e<span>2cm<\/span>\u6216\u6dcb\u5df4\u7ed3\u9633\u6027\uff09\u7684\u65b0\u8f85\u52a9\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u590d\u53d1\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u6cbb\u7597\uff1a\u672c\u54c1\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\u548c\u7d2b\u6749\u7c7b\u5316\u7597\u836f\u8054\u5408\u7528\u4e8e<span>HER2<\/span>\u9633\u6027\u3001\u8f6c\u79fb\u6027\u6216\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u590d\u53d1\u6027\u4e73\u817a\u764c\u60a3\u8005\u3002\u60a3\u8005\u65e2\u5f80\u9488\u5bf9\u8f6c\u79fb\u6027\u75be\u75c5\u5e94\u672a\u63a5\u53d7\u8fc7\u6297<span>HER2<\/span>\u6cbb\u7597\uff0c\u6216\u65e2\u5f80\u8f85\u52a9\u6cbb\u7597\u9636\u6bb5\u63a5\u53d7\u8fc7\u6297<span>HER2<\/span>\u6cbb\u7597\uff0c\u505c\u6b62\u6297<span>HER2<\/span>\u6cbb\u7597\u540e\u4e00\u5e74\u4ee5\u4e0a\u590d\u53d1\u8f6c\u79fb\u7684\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u63a5\u53d7\u5e15\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u75c5\u7076\u7ec4\u7ec7\u6807\u672c\uff0c\u5e94\u5728\u6709\u8d44\u8d28\u7684\u75c5\u7406\u5b9e\u9a8c\u5ba4\u8fdb\u884c<span>HER2<\/span>\u68c0\u6d4b\uff0c<span>HER2<\/span>\u9633\u6027\u60a3\u8005\u65b9\u53ef\u5e94\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5e15\u59a5\u73e0\u5355\u6297\u7684\u63a8\u8350\u8d77\u59cb\u5242\u91cf\u4e3a<span>840mg<\/span>\uff0c\u9759\u8109\u8f93\u6ce8<span>60<\/span>\u5206\u949f\uff0c\u6b64\u540e\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u7ed9\u836f\u5242\u91cf\u4e3a<span>420mg<\/span>\uff0c\u8f93\u6ce8\u65f6\u95f4<span>30<\/span>\uff5e<span>60<\/span>\u5206\u949f\u3002\u5728\u6bcf\u6b21\u5b8c\u6210\u5e15\u59a5\u73e0\u5355\u6297\u8f93\u6db2\u540e\uff0c\u5efa\u8bae\u89c2\u5bdf<span>30<\/span>\uff5e<span>60<\/span>\u5206\u949f\u3002\u89c2\u5bdf\u65f6\u95f4\u7ed3\u675f\u540e\u65b9\u53ef\u7ed9\u4e88\u540e\u7eed\u66f2\u59a5\u73e0\u5355\u6297\u6216\u5316\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5e15\u59a5\u73e0\u5355\u6297\u548c\u66f2\u59a5\u73e0\u5355\u6297\u5fc5\u987b\u5e8f\u8d2f\u7ed9\u836f\uff0c\u4f46\u5148\u540e\u987a\u5e8f\u5747\u53ef\u3002\u5728\u4e0e\u5e15\u59a5\u73e0\u5355\u6297\u8054\u5408\u4f7f\u7528\u65f6\uff0c\u66f2\u59a5\u73e0\u5355\u6297\u7684\u4f7f\u7528\u5efa\u8bae\u91c7\u7528\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\u4f7f\u7528\uff1b\u5bf9\u4e8e\u63a5\u53d7\u7d2b\u6749\u7c7b\u836f\u7269\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u5e15\u59a5\u73e0\u5355\u6297\u548c\u66f2\u59a5\u73e0\u5355\u6297\u7ed9\u836f\u5e94\u5148\u4e8e\u7d2b\u6749\u7c7b\u836f\u7269\uff1b\u5bf9\u4e8e\u63a5\u53d7\u84bd\u73af\u7c7b\u836f\u7269\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u5e15\u59a5\u73e0\u5355\u6297\u548c\u66f2\u59a5\u73e0\u5355\u6297\u5e94\u5728\u5b8c\u6210\u5b8c\u6574\u84bd\u73af\u7c7b\u836f\u7269\u6cbb\u7597\u65b9\u6848\u540e\u7ed9\u4e88\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5e15\u59a5\u73e0\u5355\u6297\u7a00\u91ca\u4e8e<span>250ml<\/span>\u7684<span>0.9%<\/span>\u6c2f\u5316\u94a0\u4e2d\uff0c\u4e0d\u5f97\u4f7f\u7528<span>5%<\/span>\u8461\u8404\u7cd6\u6eb6\u6db2\u7a00\u91ca\u5e15\u59a5\u73e0\u5355\u6297\uff0c\u540c\u65f6\u4e5f\u4e0d\u5f97\u4e0e\u5176\u4ed6\u836f\u7269\u6df7\u5408\u6216\u7a00\u91ca\u3002\u914d\u7f6e\u597d\u540e\u5e94\u8f7b\u8f7b\u5012\u7f6e\u8f93\u6db2\u888b\u4ee5\u6df7\u5408\u6eb6\u6db2\uff0c\u907f\u514d\u8d77\u6ce1\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u672f\u524d\u65b0\u8f85\u52a9\u6cbb\u7597\u65f6\uff0c\u5efa\u8bae\u60a3\u8005\u63a5\u53d7<span>4<\/span>\uff5e<span>6<\/span>\u4e2a\u5468\u671f\u7684\u542b\u5e15\u59a5\u73e0\u5355\u6297\u8054\u5408\u6cbb\u7597\u3002\u7528\u4e8e\u8f85\u52a9\u6cbb\u7597\u65f6\uff08\u624b\u672f\u540e\uff09\uff0c\u4f5c\u4e3a\u65e9\u671f\u4e73\u817a\u764c\u5b8c\u6574\u6cbb\u7597\u65b9\u6848\u7684\u4e00\u90e8\u5206\uff08\u5305\u62ec\u6807\u51c6\u7684\u84bd\u73af\u7c7b\u548c<span>\/<\/span>\u6216\u7d2b\u6749\u7c7b\u5316\u7597\uff09\uff0c\u5e15\u59a5\u73e0\u5355\u6297\u5e94\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\u8054\u5408\u4f7f\u7528\uff0c\u7597\u7a0b\u4e00\u5e74\u3002\u7528\u4e8e\u590d\u53d1\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u6cbb\u7597\u65f6\uff0c\u5e15\u59a5\u73e0\u5355\u6297\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\u548c\u7d2b\u6749\u7c7b\u5316\u7597\u836f\u7269\u8054\u5408\u4f7f\u7528\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u63a7\u5236\u7684\u6bd2\u6027\uff0c\u5373\u4f7f\u7ec8\u6b62\u5316\u7597\u540e\uff0c\u5e15\u59a5\u73e0\u5355\u6297\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\u7684\u6cbb\u7597\u4e5f\u53ef\u7ee7\u7eed\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5728\u9996\u6b21\u63a5\u53d7\u5e15\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u4e4b\u524d\u8bc4\u4f30<span>LVEF<\/span>\uff0c\u5e76\u5728\u6cbb\u7597\u671f\u95f4\u4e88\u4ee5\u5b9a\u671f\u8bc4\u4f30\uff08\u7ea6<span>4<\/span>\u4e2a\u5468\u671f\u89c1\u8868<span>6<\/span>\uff09\uff0c\u4ee5\u786e\u4fdd<span>LVEF<\/span>\u5728\u6b63\u5e38\u8303\u56f4\u5185\uff08\uff1e<span>50%<\/span>\uff09\u3002\u5982\u679c<span>LVEF<\/span>\u4e0b\u964d\u5e76\u672a\u6539\u5584\uff0c\u6216\u8005\u5728\u540e\u7eed\u8bc4\u4f30\u4e2d\u8fdb\u4e00\u6b65\u4e0b\u964d\uff0c\u5e94\u8003\u8651\u505c\u7528\u5e15\u59a5\u73e0\u5355\u6297\u53ca\u66f2\u59a5\u73e0\u5355\u6297\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e34\u5e8a\u7814\u7a76\u8bc1\u5b9e\uff0c<span>HER2<\/span>\u9633\u6027\u590d\u53d1\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\uff0c\u5728\u5176\u4ed6\u5316\u7597\u836f\u7269\u6216\u5185\u5206\u6ccc\u836f\u7269\u6cbb\u7597\u65f6\uff0c\u8054\u5408\u5e15\u59a5\u73e0\u5355\u6297\u548c\u66f2\u59a5\u73e0\u5355\u6297\u53ef\u8fdb\u4e00\u6b65\u589e\u52a0\u4e34\u5e8a\u83b7\u76ca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u59a5\u73e0\u5355\u6297\u7528\u4e8e<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u548c\u9752\u5c11\u5e74\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5c1a\u672a\u786e\u5b9a\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8868<span>6<\/span>&emsp;\u5de6\u5fc3\u5ba4\u529f\u80fd\u4e0d\u5168\u7684\u5e15\u59a5\u73e0\u5355\u6297\u5242\u91cf\u63a8\u8350<span><\/span><\/span><\/b>\n<\/p>\n<div align=\"center\">\n<table class=\"MsoNormalTable ke-zeroborder\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"1115\" style=\"border-collapse:collapse;\">\n<tbody>\n<tr>\n<td width=\"175\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n\t\t\t\t\t<a name=\"OLE_LINK93\"><\/a><a name=\"OLE_LINK94\"><\/a> <\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"> <\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"175\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u524d\u7684<span>LVEF<\/span>\uff1a<span><\/span><\/span><\/b>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"175\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">LVEF<\/span><\/b><b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76d1\u6d4b\u95f4\u9694\uff1a<span><\/span><\/span><\/b>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"295\" colspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5f53<span>LVEF<\/span>\u4e0b\u964d\u81f3\u4ee5\u4e0b\u6c34\u5e73\uff0c\u5e15\u59a5\u73e0\u5355\u6297\u548c\u66f2\u59a5\u73e0\u5355\u6297\u81f3\u5c11\u6682\u505c<span>3<\/span>\u5468\uff1a<span><\/span><\/span><\/b>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"295\" colspan=\"3\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c<span>LVEF<\/span>\u7f13\u89e3\u81f3\u4ee5\u4e0b\u6c34\u5e73\uff0c\u5219\u5728<span>3<\/span>\u5468\u540e\u91cd\u65b0\u4f7f\u7528\u5e15\u59a5\u73e0\u5355\u6297\u548c\u66f2\u59a5\u73e0\u5355\u6297\uff1a<span><\/span><\/span><\/b>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"175\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f6c\u79fb\u6027\u4e73\u817a\u764c<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"175\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2265<span>50%<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"175\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea6<span>12<\/span>\u5468<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"148\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1c<span>40%<\/span>\u6216<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"148\" colspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">40%<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>45%<\/span>\uff0c\u4e0e\u6cbb\u7597\u524d\u7edd\u5bf9\u6570\u503c\u76f8\u6bd4\u964d\u4f4e\u4e86\u2265<span>10%<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"147\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1e<span>45%<\/span>\u6216<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"147\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">40%<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>45%<\/span>\uff0c\u4e0e\u6cbb\u7597\u524d\u7edd\u5bf9\u6570\u503c\u76f8\u6bd4\u964d\u4f4e\u4e86\uff1c<span>10%<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"175\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e9\u671f\u4e73\u817a\u764c<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"175\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2265<span>55%<sup>*<\/sup><\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"175\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea6<span>12<\/span>\u5468\uff08\u5728\u65b0\u8f85\u52a9\u6cbb\u7597\u671f\u95f4\u76d1\u6d4b\u4e00\u6b21\uff09<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"296\" colspan=\"3\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1c<span>50%<\/span>\uff0c\u4e14\u4e0e\u6cbb\u7597\u524d\u7edd\u5bf9\u6570\u503c\u76f8\u6bd4\u964d\u4f4e\u4e86\u2265<span>10%<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"147\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2265<span>50%<\/span>\u6216<span><\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<td width=\"147\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0e\u6cbb\u7597\u524d\u7edd\u5bf9\u6570\u503c\u76f8\u6bd4\u964d\u4f4e\u4e86\uff1c<span>10%<\/span><\/span>\n\t\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"175\" style=\"border:none;\">\n\t\t\t\t<\/td>\n<td width=\"175\" style=\"border:none;\">\n\t\t\t\t<\/td>\n<td width=\"175\" style=\"border:none;\">\n\t\t\t\t<\/td>\n<td width=\"148\" style=\"border:none;\">\n\t\t\t\t<\/td>\n<td width=\"147\" style=\"border:none;\">\n\t\t\t\t<\/td>\n<td width=\"1\" style=\"border:none;\">\n\t\t\t\t<\/td>\n<td width=\"147\" style=\"border:none;\">\n\t\t\t\t<\/td>\n<td width=\"147\" style=\"border:none;\">\n\t\t\t\t<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<sup><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">*<\/span><\/sup><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u63a5\u53d7\u84bd\u73af\u7c7b\u836f\u7269\u5316\u7597\u7684\u60a3\u8005\uff0c\u5728\u5b8c\u6210\u84bd\u73af\u7c7b\u836f\u7269\u5316\u7597\u4e4b\u540e\u548c\u5728\u9996\u6b21\u5e15\u59a5\u73e0\u5355\u6297\u548c\u66f2\u59a5\u73e0\u5355\u6297\u4e4b\u524d\uff0c<span>LVEF<\/span>\u503c\u9700\u2265<span>50%<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56db\u3001\u4f0a\u5c3c\u59a5\u5355\u6297<span> Inetetamab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9488\u5242\uff1a<span>50mg\/<\/span>\u652f<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u9002\u7528\u4e8e<span>HER2<\/span>\u9633\u6027\uff0c\u4e0e\u957f\u6625\u745e\u6ee8\u8054\u5408\u6cbb\u7597\u5df2\u63a5\u53d7\u8fc7<span>1<\/span>\u4e2a\u6216\u591a\u4e2a\u5316\u7597\u65b9\u6848\u7684\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u63a5\u53d7\u4f0a\u5c3c\u59a5\u5355\u6297\u6cbb\u7597\u524d\uff0c\u5e94\u5728\u6709\u8d44\u8d28\u7684\u75c5\u7406\u5b9e\u9a8c\u5ba4\u8fdb\u884c<span>HER2<\/span>\u68c0\u6d4b\uff0c<span>HER2<\/span>\u9633\u6027\u60a3\u8005\u65b9\u53ef\u5e94\u7528\u4f0a\u5c3c\u59a5\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u5c3c\u59a5\u5355\u6297\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76\u4e2d\u4f7f\u7528\u4e86\u5355\u5468\u7528\u836f\u65b9\u6848\u548c\u4e09\u5468\u7528\u836f\u65b9\u6848\u3002\u5355\u5468\u7528\u836f\u65b9\u6848\u4e2d\u4f0a\u5c3c\u59a5\u5355\u6297\u7684\u63a8\u8350\u521d\u59cb\u8d1f\u8377\u5242\u91cf\u4e3a<span>4mg\/kg<\/span>\uff0c\u9759\u8109\u6ef4\u6ce8<span>90<\/span>\u5206\u949f\u4ee5\u4e0a\uff1b\u7ef4\u6301\u5242\u91cf\u4e3a<span>2mg\/kg<\/span>\uff0c\u6bcf\u5468\u4e00\u6b21\u3002\u4e09\u5468\u7528\u836f\u65b9\u6848\u4e2d\u4f0a\u5c3c\u59a5\u5355\u6297\u7684\u63a8\u8350\u521d\u59cb\u8d1f\u8377\u5242\u91cf\u4e3a<span>8mg\/kg<\/span>\uff0c\u9759\u8109\u6ef4\u6ce8<span>90<\/span>\u5206\u949f\u4ee5\u4e0a\uff1b\u7ef4\u6301\u5242\u91cf\u4e3a<span>6mg\/kg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0e\u84bd\u73af\u7c7b\u836f\u7269\u540c\u671f\u5e94\u7528\u987b\u614e\u91cd\uff0c\u53ef\u80fd\u589e\u52a0\u5fc3\u810f\u6bd2\u6027\uff0c\u4e25\u91cd\u8005\u4f1a\u53d1\u751f\u5fc3\u529b\u8870\u7aed\uff0c\u5e94\u5e8f\u8d2f\u4f7f\u7528\u6216\u5206\u522b\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f7f\u7528\u4f0a\u5c3c\u59a5\u5355\u6297\u6cbb\u7597\u524d\uff0c\u5e94\u8fdb\u884c\u75c5\u53f2\u3001\u4f53\u68c0\u3001\u5fc3\u7535\u56fe\u3001\u8d85\u58f0\u5fc3\u52a8\u56fe<span>LVEF<\/span>\u57fa\u7ebf\u8bc4\u4f30\uff0c\u4f7f\u7528\u671f\u95f4\u5e94\u6bcf<span>3<\/span>\u4e2a\u6708\u76d1\u6d4b<span>LVEF<\/span>\u3002\u82e5<span>LVEF<\/span>\u503c\u76f8\u5bf9\u57fa\u7ebf\u4e0b\u964d\uff1e<span>10%<\/span>\uff0c\u5e76\u4e14\u4e0b\u964d\u81f3<span>50%<\/span>\u4ee5\u4e0b\uff0c\u5219\u5e94\u6682\u505c\u4f7f\u7528\u4f0a\u5c3c\u59a5\u5355\u6297\uff0c\u5e76\u5728\u7ea6<span>3<\/span>\u5468\u5185\u91cd\u590d\u8bc4\u4f30<span>LVEF<\/span>\u3002\u82e5<span>LVEF<\/span>\u65e0\u6539\u5584\u6216\u8fdb\u4e00\u6b65\u4e0b\u964d\uff0c\u6216\u51fa\u73b0\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\uff0c\u5219\u5f3a\u70c8\u5efa\u8bae\u7ec8\u6b62\u4f0a\u5c3c\u59a5\u5355\u6297\u7528\u836f\u3002\u5bf9\u4e8e\u53d1\u751f\u65e0\u75c7\u72b6\u5fc3\u529f\u80fd\u4e0d\u5168\u7684\u60a3\u8005\uff0c\u5e94\u9891\u7e41\u76d1\u6d4b\uff08\u5982\u6bcf<span>6<\/span>\uff5e<span>8<\/span>\u5468\u4e00\u6b21\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u63a8\u8350\u5408\u5e76\u6709\u4ee5\u4e0b\u75be\u75c5\u7684\u60a3\u8005\u4f7f\u7528\u672c\u54c1\uff1a\uff08<span>1<\/span>\uff09\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\u3002\uff08<span>2<\/span>\uff09\u9ad8\u5371\u3001\u672a\u63a7\u5236\u5fc3\u5f8b\u5931\u5e38\u3002\uff08<span>3<\/span>\uff09\u9700\u8981\u836f\u7269\u6cbb\u7597\u7684\u5fc3\u7ede\u75db\u3002\uff08<span>4<\/span>\uff09\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u5fc3\u74e3\u819c\u75be\u75c5\u3002\uff08<span>5<\/span>\uff09\u5fc3\u7535\u56fe\u63d0\u793a\u900f\u58c1\u6027\u5fc3\u808c\u6897\u6b7b\u3002\uff08<span>6<\/span>\uff09\u63a7\u5236\u4e0d\u4f73\u7684\u9ad8\u8840\u538b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f7f\u7528\u4f0a\u5c3c\u59a5\u5355\u6297\u53d1\u751f\u547c\u5438\u56f0\u96be\u6216\u8005\u4e34\u5e8a\u663e\u8457\u7684\u4f4e\u8840\u538b\u65f6\u5e94\u4e2d\u65ad\u8f93\u6ce8\uff0c\u540c\u65f6\u7ed9\u4e88\u76f8\u5e94\u836f\u7269\u6cbb\u7597\uff0c\u5305\u62ec\u80be\u4e0a\u817a\u7d20\u3001\u7cd6\u76ae\u8d28\u6fc0\u7d20\u3001\u82ef\u6d77\u62c9\u660e\u3001\u652f\u6c14\u7ba1\u6269\u5f20\u5242\u548c\u6c27\u6c14\u7b49\u3002\u53d1\u751f\u4e25\u91cd\u548c\u5371\u53ca\u751f\u547d\u7684\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\u7684\u60a3\u8005\u5e94\u6c38\u4e45\u505c\u6b62\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><a name=\"_Hlk44948457\"><\/a><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f0a\u5c3c\u59a5\u5355\u6297\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u663e\u793a\uff0c\u4f0a\u5c3c\u59a5\u5355\u6297\u8054\u5408\u957f\u6625\u745e\u6ee8\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7<span>1<\/span>\u4e2a\u6216\u591a\u4e2a\u5316\u7597\u65b9\u6848\u7684<span>HER2<\/span>\u9633\u6027\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\uff0c\u5bf9\u6bd4\u957f\u6625\u745e\u6ee8\u53ef\u663e\u8457\u5ef6\u957f\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08<span>39.1<\/span>\u5468<i><span>vs<\/span><\/i><span>14.0<\/span>\u5468\uff0c<span>HR<\/span>\uff1d<span>0.24<\/span>\uff0c<i><span>p<\/span><\/i>\uff1c<span>0.0001<\/span>\uff09\uff0c\u4f7f\u5f97\u60a3\u8005\u4e34\u5e8a\u83b7\u76ca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e94\u3001\u62c9\u5e15\u66ff\u5c3c<span> Lapatinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>0.25g<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u62c9\u5e15\u66ff\u5c3c\u4e0e\u5361\u57f9\u4ed6\u6ee8\u8054\u7528\uff0c\u9002\u7528\u4e8e<span>HER2<\/span>\u8fc7\u8868\u8fbe\u4e14\u65e2\u5f80\u63a5\u53d7\u8fc7\u5305\u62ec\u84bd\u73af\u7c7b\u3001\u7d2b\u6749\u7c7b\u548c\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u7684\u665a\u671f\u6216\u8005\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8003\u8651\u4f7f\u7528\u672c\u836f\u7684\u60a3\u8005\u9700\u8fdb\u884c\u7ec4\u7ec7\u6807\u672c\uff08\u539f\u53d1\u7076\u6216\u8f6c\u79fb\u7076\uff09\u7684<span>HER2<\/span>\u68c0\u6d4b\uff0c\u65e0\u8bba\u662f\u539f\u53d1\u7076\u8fd8\u662f\u8f6c\u79fb\u7076\uff0c<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">HER2<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9633\u6027\u60a3\u8005\u65b9\u53ef\u5e94\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4ec5\u9002\u7528\u4e8e\u590d\u53d1\u8f6c\u79fb\u60a3\u8005\uff0c\u539f\u5219\u4e0a\u4e0d\u63a8\u8350\u4e00\u7ebf\u4f7f\u7528\uff0c\u9664\u975e\u662f\u60a3\u8005\u6709\u66f2\u59a5\u73e0\u5355\u6297\u7684\u7981\u5fcc\u8bc1\u6216\u53c2\u52a0\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5355\u72ec\u4f7f\u7528\u65f6<span>1.25g<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\/<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b21<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u7b2c<span>1<\/span>\uff5e<span>21<\/span>\u5929\u8fde\u7eed\u670d\u7528\u3002\u4e0e\u5361\u57f9\u4ed6\u6ee8\u8054\u7528\u65f6\uff0c\u62c9\u5e15\u66ff\u5c3c\u7684\u63a8\u8350\u5242\u91cf\u540c\u4e0a\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u6bcf<span>21<\/span>\u5929<span>1<\/span>\u4e2a\u5468\u671f\uff0c\u5efa\u8bae\u5c06\u6bcf\u5929\u5242\u91cf\u4e00\u6b21\u6027\u670d\u7528\uff0c\u4e0d\u63a8\u8350\u5206\u6b21\u670d\u7528\u3002\u5e94\u5728\u9910\u524d\u81f3\u5c11<span>1<\/span>\u5c0f\u65f6\uff0c\u6216\u9910\u540e\u81f3\u5c11<span>1<\/span>\u5c0f\u65f6\u670d\u7528\u3002\u5361\u57f9\u4ed6\u6ee8\u63a8\u8350\u5242\u91cf\u4e3a<span>2g\/<\/span>\uff08<span>m<sup>2<\/sup><\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:;\" \"=\"\">\u25aa<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">d<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff09\uff0c\u5206\u4e24\u6b21\u53e3\u670d\u3002\u95f4\u9694\u7ea6<span>12<\/span>\u5c0f\u65f6\uff0c\u8fde\u670d<span>14<\/span>\u5929\uff0c\u4f11\u606f<span>7<\/span>\u5929\uff0c<span>21<\/span>\u5929\u4e3a\u4e00\u4e2a\u5468\u671f\u3002\u5361\u57f9\u4ed6\u6ee8\u5e94\u548c\u98df\u7269\u540c\u65f6\u670d\u7528\uff0c\u6216\u9910\u540e<span>30<\/span>\u5206\u949f\u5185\u670d\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e3b\u8981\u4e0d\u826f\u53cd\u5e94\u4e3a\u8179\u6cfb\u548c\u76ae\u75b9\uff0c\u8179\u6cfb\u53ef\u5bf9\u75c7\u6b62\u6cfb\uff0c\u7528\u836f\u671f\u95f4\u907f\u514d\u76f4\u63a5\u65e5\u6652\uff0c\u5916\u51fa\u6ce8\u610f\u9632\u6652\u3002\u4f7f\u7528\u672c\u54c1\u53ef\u53d1\u751f\u5fc3\u810f\u6bd2\u6027\uff0c\u4e3b\u8981\u8868\u73b0\u4e3a<span>LVEF<\/span>\u51cf\u4f4e\uff0c\u5efa\u8bae\u6cbb\u7597\u524d\u8bc4\u4f30<span>LVEF<\/span>\uff0c\u6cbb\u7597\u4e2d\u5b9a\u671f\u68c0\u6d4b<span>LVEF<\/span>\uff0c\u82e5<span>LVEF<\/span>\u4e0b\u964d\u81f3\u6b63\u5e38\u503c\u4e0b\u9650\uff0c\u6216\u51fa\u73b0<span>2<\/span>\u7ea7\u6216<span>2<\/span>\u7ea7\u4ee5\u4e0a\u4e0e<span>LVEF<\/span>\u4e0b\u964d\u76f8\u5173\u7684\u75c7\u72b6\uff0c\u5e94\u505c\u836f\u3002\u82e5\u6062\u590d\u81f3\u6b63\u5e38\uff0c\u4e14\u60a3\u8005\u65e0\u75c7\u72b6\uff0c\u53ef\u4ee5\u5728\u505c\u7528\u81f3\u5c11<span>2<\/span>\u5468\u540e\u5c06\u672c\u54c1\u51cf\u91cf\u4f7f\u7528\uff08\u6bcf\u5929<span>1g<\/span>\u4e0e\u5361\u57f9\u4ed6\u6ee8\u8054\u7528\uff09\u3002\u90e8\u5206\u75c5\u4eba\u8fd8\u53ef\u51fa\u73b0\u809d\u529f\u80fd\u635f\u4f24\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u60a3\u8005\u6f0f\u670d\u4e86\u67d0\u4e00\u5929\u7684\u5242\u91cf\uff0c\u7b2c\u4e8c\u5929\u7684\u5242\u91cf\u4e0d\u8981\u52a0\u500d\uff0c\u5728\u4e0b\u4e00\u6b21\u670d\u836f\u65f6\u95f4\u6309\u8ba1\u5212\u7ee7\u7eed\u670d\u7528\u5373\u53ef\u3002\u6cbb\u7597\u5e94\u5f53\u6301\u7eed\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u80fd\u8010\u53d7\u7684\u6bd2\u6027\u53cd\u5e94\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u4e3b\u8981\u7ecf<span>CYP3A4<\/span>\u4ee3\u8c22\u3002\u670d\u836f\u671f\u95f4\u7981\u98df\u8461\u8404\u67da\u3001\u8461\u8404\u67da\u679c\u6c41\uff0c\u4e0e<span>CYP3A4<\/span>\u6291\u5236\u5242\u6216\u8bf1\u5bfc\u5242\u8054\u5408\u7ed9\u836f\u65f6\u9700\u8c28\u614e\uff0c\u8c28\u614e\u4e0e\u8d28\u5b50\u6cf5\u6291\u5236\u5242\u5408\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e5f\u6709\u4e34\u5e8a\u7814\u7a76\u8bc1\u660e\uff0c\u62c9\u5e15\u66ff\u5c3c\u8054\u5408\u5176\u4ed6\u5316\u7597\u836f\u7269\u6216\u5185\u5206\u6ccc\u6cbb\u7597\u836f\u7269\u53ef\u4f7f\u75c5\u4eba\u4e34\u5e8a\u83b7\u76ca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u516d\u3001\u5421\u54af\u66ff\u5c3c<span> Pyrotinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>80mg<\/span>\u3001<span>160mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5421\u54af\u66ff\u5c3c\u8054\u5408\u5361\u57f9\u4ed6\u6ee8\uff0c\u9002\u7528\u4e8e\u6cbb\u7597<span>HER2<\/span>\u9633\u6027\u3001\u65e2\u5f80\u672a\u63a5\u53d7\u6216\u63a5\u53d7\u8fc7\u66f2\u59a5\u73e0\u5355\u6297\u7684\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u3002\u4f7f\u7528\u5421\u54af\u66ff\u5c3c\u524d\u60a3\u8005\u5e94<a name=\"_Hlk44948602\"><\/a>\u63a5\u53d7\u8fc7\u84bd\u73af\u7c7b\u6216\u7d2b\u6749\u7c7b\u5316\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u4f7f\u7528\u5421\u54af\u66ff\u5c3c\u6cbb\u7597\u524d\uff0c\u5e94\u4f7f\u7528\u7ecf\u5145\u5206\u9a8c\u8bc1\u7684\u68c0\u6d4b\u65b9\u6cd5\u8fdb\u884c<span>HER2<\/span>\u72b6\u6001\u7684\u68c0\u6d4b\u3002\u5421\u54af\u66ff\u5c3c\u4ec5\u53ef\u7528\u4e8e<span>HER2<\/span>\u9633\u6027\u7684\u4e73\u817a\u764c\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u7528\u4e8e<span>HER2<\/span>\u9633\u6027\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53ea\u8981\u89c2\u5bdf\u5230\u4e34\u5e8a\u83b7\u76ca\uff0c\u5e94\u7ee7\u7eed\u5421\u54af\u66ff\u5c3c\u6cbb\u7597\uff0c\u76f4\u81f3\u60a3\u8005\u4e0d\u80fd\u8010\u53d7\u6216\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5421\u54af\u66ff\u5c3c\u63a8\u8350\u5242\u91cf\u4e3a<span>400mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u9910\u540e<span>30<\/span>\u5206\u949f\u5185\u53e3\u670d\uff0c\u6bcf\u5929\u540c\u4e00\u65f6\u95f4\u670d\u836f\u3002\u8fde\u7eed\u670d\u7528\uff0c\u6bcf<span>21<\/span>\u5929\u4e3a\u4e00\u4e2a\u5468\u671f\u3002\u5982\u679c\u60a3\u8005\u6f0f\u670d\u67d0\u4e00\u5929\u7684\u5421\u54af\u66ff\u5c3c\uff0c\u4e0d\u9700\u8981\u8865\u670d\uff0c\u4e0b\u4e00\u6b21\u6309\u8ba1\u5212\u670d\u836f\u5373\u53ef\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u5982\u60a3\u8005\u51fa\u73b0\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u901a\u8fc7\u6682\u505c\u7ed9\u836f\u3001\u964d\u4f4e\u5242\u91cf\u6216\u8005\u505c\u6b62\u7ed9\u836f\u8fdb\u884c\u7ba1\u7406\u3002\u5bf9\u4e8e\u8179\u6cfb\u3001\u76ae\u80a4\u4e0d\u826f\u53cd\u5e94\u53ef\u9996\u5148\u8fdb\u884c\u5bf9\u75c7\u6cbb\u7597\u5e76\u5bc6\u5207\u89c2\u5bdf\u3002\u4e00\u4e9b\u6301\u7eed\u5b58\u5728\u7684<span>2<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\u4e5f\u53ef\u80fd\u9700\u8981\u591a\u6b21\u6682\u505c\u7528\u836f\u548c<span>\/<\/span>\u6216\u4e0b\u8c03\u5242\u91cf\u3002\u5982\u6682\u505c\u7ed9\u836f\u540e\u53d7\u8bd5\u8005\u4ecd\u6709\u4e34\u5e8a\u4e0d\u53ef\u63a7\u5236\uff08\u5373\u4e34\u5e8a\u6cbb\u7597\u6216\u89c2\u5bdf\u2264<span>14<\/span>\u5929\u540e\u4ecd\u5b58\u5728\uff0c\u51fa\u73b0\u2265\u4e24\u6b21\uff09\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5219\u5728\u6682\u505c\u540e\u6062\u590d\u7528\u836f\u65f6\u5e94\u51cf\u5c11\u4e00\u4e2a\u6c34\u5e73\u7684\u5242\u91cf\uff0c\u5421\u54af\u66ff\u5c3c\u5141\u8bb8\u4e0b\u8c03\u6700\u4f4e\u5242\u91cf\u4e3a<span>240mg<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u5408\u5e76\u4f7f\u7528<span>CYP3A4<\/span>\u5f3a\u6291\u5236\u5242\u548c\u5f3a\u8bf1\u5bfc\u5242\uff0c\u5e94\u5bc6\u5207\u76d1\u6d4b\uff0c\u7ed3\u5408\u4e34\u5e8a\u89c2\u5bdf\u8003\u8651\u662f\u5426\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5421\u54af\u66ff\u5c3c\u4e3b\u8981\u7ecf\u809d\u810f\u4ee3\u8c22\uff0c\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u7684\u60a3\u8005\u4e0d\u63a8\u8350\u4f7f\u7528\u3002\u80be\u529f\u80fd\u635f\u4f24\u5bf9\u5421\u54af\u66ff\u5c3c\u66b4\u9732\u5f71\u54cd\u975e\u5e38\u6709\u9650\uff0c\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4ecd\u5e94\u5728\u533b\u5e08\u6307\u5bfc\u4e0b\u8c28\u614e\u4f7f\u7528\u5421\u54af\u66ff\u5c3c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8179\u6cfb\u662f\u5421\u54af\u66ff\u5c3c\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u89c2\u5bdf\u5230\u7684\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u3002\u6cbb\u7597\u671f\u95f4\u60a3\u8005\u5e94\u5173\u6ce8\u6392\u4fbf\u6027\u72b6\u548c\u9891\u7387\u7684\u53d8\u5316\uff0c\u53d1\u73b0\u5927\u4fbf\u4e0d\u6210\u5f62\u540e\uff0c\u5c3d\u65e9\u5f00\u59cb\u6297\u8179\u6cfb\u6cbb\u7597\uff0c\u53ef\u9009\u7528\u6d1b\u54cc\u4e01\u80fa\u6216\u8499\u8131\u77f3\u6563\u3002\u5982\u51fa\u73b0\u6301\u7eed\u7684<span>3<\/span>\u7ea7\u8179\u6cfb\u3001\u6216<span>1<\/span>\uff5e<span>2<\/span>\u7ea7\u8179\u6cfb\u4f34\u5e76\u53d1\u75c7\uff08\u2265<span>2<\/span>\u7ea7\u7684\u6076\u5fc3\u3001\u5455\u5410\u3001\u53d1\u70ed\u3001\u4fbf\u8840\u6216\u8131\u6c34\u7b49\uff09\u65f6\uff0c\u60a3\u8005\u5e94\u7acb\u5373\u8054\u7cfb\u533b\u5e08\u5e76\u63a5\u53d7\u6cbb\u7597\u4e0a\u7684\u6307\u5bfc\uff0c\u5c3d\u65e9\u5f00\u59cb\u5bf9\u75c7\u6cbb\u7597\u3002\u53d1\u751f\u8179\u6cfb\u540e\u53ef\u6839\u636e\u5242\u91cf\u8c03\u6574\u6307\u5bfc\u539f\u5219\u8fdb\u884c\u5904\u7406\u3002\u5bf9\u4e8e\u6cbb\u7597\u671f\u95f4\u9891\u7e41\u53d1\u751f\u8179\u6cfb\u7684\u60a3\u8005\uff0c\u5e94\u8b66\u60d5\u53d1\u751f\u4e25\u91cd\u8179\u6cfb\u7684\u53ef\u80fd\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c1a\u7f3a\u4e4f\u5421\u54af\u66ff\u5c3c\u5728<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u548c\u9752\u5c11\u5e74\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5421\u54af\u66ff\u5c3c\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08<span>PUFFIN<\/span>\uff09\u6570\u636e\u663e\u793a\uff0c\u5421\u54af\u66ff\u5c3c\u8054\u5408\u5361\u57f9\u4ed6\u6ee8\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u5931\u8d25\uff0c\u540c\u65f6\u63a5\u53d7\u8fc7\u84bd\u73af\u7c7b\u6216\u7d2b\u6749\u7c7b\u5316\u7597\u7684<span>HER2<\/span>\u9633\u6027\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\uff0c\u5bf9\u6bd4\u62c9\u5e15\u66ff\u5c3c\u8054\u5408\u5361\u57f9\u4ed6\u6ee8\u53ef\u663e\u8457\u5ef6\u957f\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08<span>12.5<\/span>\u4e2a\u6708<i><span>vs<\/span><\/i><span>6.8<\/span>\u4e2a\u6708\uff0c<span>HR<\/span>\uff1d<span>0.39<\/span>\uff0c<i><span>p<\/span><\/i>\uff1c<span>0.0001<\/span>\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e03\u3001\u5948\u62c9\u66ff\u5c3c<span> Neratinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>40mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u7528\u4e8e<span>HER2<\/span>\u9633\u6027\u7684\u65e9\u671f\u4e73\u817a\u764c\u6210\u5e74\u60a3\u8005\uff0c\u5728\u63a5\u53d7\u542b\u66f2\u59a5\u73e0\u5355\u6297\u8f85\u52a9\u6cbb\u7597\u4e4b\u540e\u7684\u5f3a\u5316\u8f85\u52a9\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8003\u8651\u4f7f\u7528\u672c\u836f\u7684\u60a3\u8005\u9700\u8fdb\u884c<span>HER2<\/span>\u68c0\u6d4b\uff0c<span>HER2<\/span>\u9633\u6027\u60a3\u8005\u65b9\u53ef\u5e94\u7528\u5948\u62c9\u66ff\u5c3c\u8fdb\u884c\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5948\u62c9\u66ff\u5c3c\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>240mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u968f\u9910\u670d\u7528\uff0c\u8fde\u7eed\u7528\u836f\u4e00\u5e74\u3002\u6307\u5bfc\u60a3\u8005\u5728\u6bcf\u5929\u5927\u81f4\u540c\u4e00\u65f6\u95f4\u670d\u7528\u5948\u62c9\u66ff\u5c3c\uff0c\u5e94\u6574\u7247\u541e\u670d\u5948\u62c9\u66ff\u5c3c\uff08\u836f\u7247\u5728\u541e\u670d\u524d\u4e0d\u5f97\u5480\u56bc\u3001\u538b\u788e\u6216\u5288\u5f00\uff09\u3002\u5982\u679c\u60a3\u8005\u6f0f\u670d\uff0c\u4e0d\u5f97\u8865\u670d\u6f0f\u670d\u7684\u5242\u91cf\uff0c\u5e94\u6307\u5bfc\u60a3\u8005\u6309\u6bcf\u5929\u5242\u91cf\u4e8e\u6b21\u65e5\u91cd\u65b0\u670d\u7528\u5948\u62c9\u66ff\u5c3c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e3b\u8981\u4e0d\u826f\u53cd\u5e94\u4e3a\u8179\u6cfb\u3002\u9884\u9632\u6027\u4f7f\u7528\u6b62\u6cfb\u836f\u3001\u996e\u98df\u6539\u53d8\u4ee5\u53ca\u9002\u5f53\u8c03\u6574\u5948\u62c9\u66ff\u5c3c\u5242\u91cf\u53ef\u964d\u4f4e\u8179\u6cfb\u53d1\u751f\u7387\u548c\u8179\u6cfb\u7684\u4e25\u91cd\u7a0b\u5ea6\u3002\u6307\u5bfc\u60a3\u8005\u4e8e\u7b2c\u4e00\u5242\u5948\u62c9\u66ff\u5c3c\u7ed9\u836f\u65f6\u5373\u5f00\u59cb\u9884\u9632\u6027\u670d\u7528\u6b62\u6cfb\u836f\u6d1b\u54cc\u4e01\u80fa\uff0c\u6301\u7eed\u7528\u836f<span>2<\/span>\u4e2a\u5468\u671f\uff08<span>56<\/span>\u5929\uff09\u3002\u6d1b\u54cc\u4e01\u80fa\u7684\u9884\u9632\u6027\u7528\u836f\u65b9\u6848\u5982\u4e0b\u8868\uff1a<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8868<span>7<\/span>&emsp;\u6d1b\u54cc\u4e01\u80fa\u9884\u9632\u6027\u7528\u836f\u65b9\u6848<span><\/span><\/span><\/b>\n<\/p>\n<table class=\"MsoTableGrid\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\" style=\"border-collapse:collapse;border:none;\">\n<tbody>\n<tr>\n<td width=\"539\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5948\u62c9\u66ff\u5c3c\u7528\u836f\u65f6\u95f4<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"577\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6d1b\u54cc\u4e01\u80fa\u5242\u91cf\u548c\u670d\u836f\u9891\u7387<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"539\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7b2c<span>1<\/span>\uff5e<span>2<\/span>\u5468\uff08\u7b2c<span>1<\/span>\uff5e<span>14<\/span>\u5929\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"577\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4mg<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u6bcf\u5929\u4e09\u6b21<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"539\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7b2c<span>3<\/span>\uff5e<span>4<\/span>\u5468\uff08\u7b2c<span>15<\/span>\uff5e<span>28<\/span>\u5929\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"577\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4mg<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u6bcf\u5929\u4e24\u6b21<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"539\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7b2c<span>5<\/span>\uff5e<span>8<\/span>\u5468\uff08\u7b2c<span>29<\/span>\uff5e<span>56<\/span>\u5929\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"577\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4mg<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u6bcf\u5929\u4e24\u6b21<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"539\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7b2c<span>9<\/span>\uff5e<span>52<\/span>\u5468\uff08\u7b2c<span>57<\/span>\uff5e<span>365<\/span>\u5929\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"577\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4mg<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6309\u9700\u4f7f\u7528\uff0c\u4e0d\u5f97\u8d85\u8fc7<span>16mg\/d<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e34\u5e8a\u9700\u8981\uff0c\u53ef\u4ee5\u901a\u8fc7\u6682\u65f6\u4e2d\u65ad\u5948\u62c9\u66ff\u5c3c\u7ed9\u836f\u6216\u51cf\u5c11\u5176\u7528\u836f\u5242\u91cf\u6765\u63a7\u5236\u8179\u6cfb\uff0c\u6700\u4f4e\u5948\u62c9\u66ff\u5c3c\u670d\u7528\u5242\u91cf\u4e3a<span>120mg\/d<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u5948\u62c9\u66ff\u5c3c\u8d77\u59cb\u5242\u91cf\u964d\u4f4e\u81f3<span>80mg<\/span>\u3002\u5bf9\u4e8e\u8f7b\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u4e0d\u63a8\u8350\u5242\u91cf\u8c03\u6574\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u836f\u7269\u76f8\u4e92\u4f5c\u7528\uff1a\uff08<span>1<\/span>\uff09\u8d28\u5b50\u6cf5\u6291\u5236\u5242\uff08<span>PPI<\/span>\uff09\uff1a\u907f\u514d\u4e0e\u5948\u62c9\u66ff\u5c3c\u8054\u5408\u7528\u836f\u3002\uff08<span>2<\/span>\uff09<span>H<sub>2<\/sub><\/span>\u53d7\u4f53\u62ee\u6297\u5242\uff1a\u5728\u4e0b\u4e00\u5242<span>H<sub>2<\/sub><\/span>\u53d7\u4f53\u62ee\u6297\u5242\u7ed9\u836f\u524d\u81f3\u5c11<span>2<\/span>\u5c0f\u65f6\u6216\u5728<span>H<sub>2<\/sub><\/span>\u53d7\u4f53\u62ee\u6297\u5242\u7ed9\u836f\u540e<span>10<\/span>\u5c0f\u65f6\u670d\u7528\u5948\u62c9\u66ff\u5c3c\u3002\uff08<span>3<\/span>\uff09\u6297\u9178\u836f\uff1a\u5728\u6297\u9178\u836f\u7ed9\u836f<span>3<\/span>\u5c0f\u65f6\u540e\u65b9\u53ef\u7ed9\u4e88\u5948\u62c9\u66ff\u5c3c\u3002\uff08<span>4<\/span>\uff09\u907f\u514d\u5948\u62c9\u66ff\u5c3c\u4e0e\u5f3a\u6548\u6216\u4e2d\u7b49<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u4f34\u968f\u7528\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u4e34\u5e8a\u7814\u7a76\u8868\u660e\uff0c\u5948\u62c9\u66ff\u5c3c\u8054\u5408\u5361\u57f9\u4ed6\u6ee8\u5bf9\u6cbb\u7597\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u53ef\u4f7f\u75c5\u4eba\u4e34\u5e8a\u83b7\u76ca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u516b\u3001\u54cc\u67cf\u897f\u5229<span> Palbociclib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>75mg<\/span>\u3001<span>100mg<\/span>\u3001<span>125mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u9002\u7528\u4e8e\u6fc0\u7d20\u53d7\u4f53\uff08<span>HR<\/span>\uff09\u9633\u6027\u3001<span>HER2<\/span>\u9634\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff1a\uff08<span>1<\/span>\uff09\u4e0e\u82b3\u9999\u5316\u9176\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\uff0c\u4f5c\u4e3a\u7edd\u7ecf\u540e\u5973\u6027\u60a3\u8005\u7684\u521d\u59cb\u5185\u5206\u6ccc\u6cbb\u7597\u3002\u9274\u4e8e\u82b3\u9999\u5316\u9176\u6291\u5236\u5242\u7684\u4f5c\u7528\u673a\u5236\uff0c\u7edd\u7ecf\u524d<span>\/<\/span>\u56f4\u7edd\u7ecf\u671f\u5973\u6027\u63a5\u53d7\u54cc\u67cf\u897f\u5229\u4e0e\u82b3\u9999\u5316\u9176\u6291\u5236\u5242\u8054\u5408\u6cbb\u7597\u65f6\uff0c\u5fc5\u987b\u8fdb\u884c\u5375\u5de2\u5207\u9664\u6216\u4f7f\u7528\u4fc3\u9ec4\u4f53\u751f\u6210\u6fc0\u7d20\u91ca\u653e\u6fc0\u7d20\u6fc0\u52a8\u5242\u6291\u5236\u5375\u5de2\u529f\u80fd\u3002\uff08<span>2<\/span>\uff09\u4e0e\u6c1f\u7ef4\u53f8\u7fa4\u8054\u5408\u4f7f\u7528\u6cbb\u7597\u5185\u5206\u6ccc\u6cbb\u7597\u540e\u8fdb\u5c55\u7684\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u5973\u6027\u60a3\u8005\u3002\u54cc\u67cf\u897f\u5229\u8054\u5408\u6c1f\u7ef4\u53f8\u7fa4\u7528\u4e8e\u7edd\u7ecf\u524d<span>\/<\/span>\u56f4\u7edd\u7ecf\u671f\u5973\u6027\uff0c\u9700\u8981\u4e0e\u4fc3\u9ec4\u4f53\u751f\u6210\u6fc0\u7d20\u91ca\u653e\u6fc0\u7d20\u6fc0\u52a8\u5242\u8054\u5408\u7528\u836f\u3002\uff08<span>3<\/span>\uff09\u7537\u6027\u4e73\u817a\u764c\uff1a<span>2019<\/span>\u5e74<span>4<\/span>\u6708<span>4<\/span>\u65e5\uff0c<span>FDA<\/span>\u6279\u51c6\u4e86\u7f8e\u56fd\u54cc\u67cf\u897f\u5229<span>HR<\/span>\u9633\u6027\u3001<span>HER2<\/span>\u9634\u6027\u665a\u671f\u7537\u6027\u4e73\u817a\u764c\u7684\u9002\u5e94\u8bc1\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5728\u63a5\u53d7\u54cc\u67cf\u897f\u5229\u6cbb\u7597\u524d\uff0c\u5e94\u5728\u6709\u8d44\u8d28\u7684\u75c5\u7406\u5b9e\u9a8c\u5ba4\u8fdb\u884c\u68c0\u6d4b\u8bc1\u5b9e<span>HR<\/span>\u9633\u6027\u3001<span>HER2<\/span>\u9634\u6027\u60a3\u8005\u65b9\u53ef\u4f7f\u7528\u3002<span>HR<\/span>\u9633\u6027\u7684\u5b9a\u4e49\u4e3a\u96cc\u6fc0\u7d20\u53d7\u4f53\u514d\u75ab\u7ec4\u5316\u67d3\u8272\u663e\u793a\u8d85\u8fc7<span>1%<\/span>\u7684\u80bf\u7624\u7ec6\u80de\u6838\u67d3\u8272\u9633\u6027\u3002<span>HER2<\/span>\u9634\u6027\u7684\u5b9a\u4e49\u4e3a<span>IHC0-1+<\/span>\u6216<span>FISH<\/span>\u9634\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u8d77\u59cb\u5242\u91cf\u662f<span>125mg\/d<\/span>\uff0c<span>4<\/span>\u5468\u4e3a\u4e00\u4e2a\u7528\u836f\u5468\u671f\uff1a\u670d\u836f<span>3<\/span>\u5468\u540e\u9700\u505c\u836f<span>1<\/span>\u5468\u3002\u5e94\u4e0e\u98df\u7269\u540c\u670d\uff0c\u4e0d\u5f97\u4e0e\u8461\u8404\u67da\u6216\u8461\u8404\u67da\u6c41\u540c\u670d\uff0c\u6700\u597d\u968f\u9910\u670d\u836f\u4ee5\u786e\u4fdd\u54cc\u67cf\u897f\u5229\u66b4\u9732\u91cf\u4e00\u81f4\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5e38\u89c1\u526f\u4f5c\u7528\u4e3a\u9aa8\u9ad3\u6291\u5236\uff0c\u56e0\u6b64\u5efa\u8bae\u5728\u4f7f\u7528\u672c\u54c1\u524d\u884c\u8840\u5e38\u89c4\u68c0\u67e5\uff0c\u5728\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u8ba1\u6570\u2265<span>1<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u4e14\u8840\u5c0f\u677f\u8ba1\u6570\u2265<span>50<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u65f6\u5f00\u59cb\u63a5\u53d7\u6cbb\u7597\u3002\u5728\u7b2c<span>15<\/span>\u5929\u68c0\u6d4b\u8840\u5e38\u89c4\uff0c\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u8ba1\u6570<span>0.5<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u81f3\u2264<span>1<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u65f6\uff0c\u53ef\u4ee5\u7ee7\u7eed\u670d\u836f\u81f3<span>21<\/span>\u5929\u3002\u5982\u679c\u7b2c<span>15<\/span>\u5929\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u8ba1\u6570\u2264<span>0.5<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u65f6\uff0c\u9700\u6682\u505c\u670d\u7528\u54cc\u67cf\u897f\u5229\uff0c\u76f4\u81f3\u6062\u590d\u81f3\u2265<span>1<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff0c\u518d\u4ee5\u964d\u4f4e\u4e00\u4e2a\u5242\u91cf\u7ea7\u5f00\u59cb\u4e0b\u4e00\u7597\u7a0b\u6cbb\u7597\u3002\u5982\u679c\u4e0b\u4e2a\u7597\u7a0b\u524d\u4e00\u5929\u68c0\u6d4b\u8840\u5e38\u89c4\uff0c\u4e2d\u6027\u7c92\u7ec6\u80de\u6062\u590d\u81f3\u2265<span>1<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff0c\u53ef\u4ee5\u539f\u5242\u91cf\u5f00\u59cb\u4e0b\u4e00\u7597\u7a0b\uff0c\u4f46\u5982\u679c\u5ef6\u8fdf\u6062\u590d\uff0c\u5219\u9700\u8981\u964d\u4f4e\u4e00\u4e2a\u5242\u91cf\u7ea7\u5f00\u59cb\u4e0b\u4e00\u7597\u7a0b\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u907f\u514d\u4f34\u968f\u4f7f\u7528<span>CYP3A<\/span>\u5f3a\u6548\u6291\u5236\u5242\uff0c\u8003\u8651\u5f3a\u6548\u6291\u5236\u5242\u66ff\u6362\u4e3a\u6ca1\u6709\u6216\u53ea\u5fae\u5f31<span>CYP3A<\/span>\u6291\u5236\u4f5c\u7528\u7684\u5176\u4ed6\u4f34\u968f\u7528\u836f\u3002\u5982\u679c\u60a3\u8005\u5fc5\u987b\u4f34\u968f\u7528\u836f<span>CYP3A<\/span>\u5f3a\u6548\u6291\u5236\u5242\uff0c\u5219\u5c06\u54cc\u67cf\u897f\u5229\u5242\u91cf\u51cf\u5c11\u81f3<span>75mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u3002\u5982\u679c\u505c\u7528\u5f3a\u6548\u6291\u5236\u5242\uff0c\u5219\u5c06\u54cc\u67cf\u897f\u5229\u7684\u5242\u91cf\u589e\u52a0\u81f3\u5f00\u59cb\u4f7f\u7528<span>CYP3A<\/span>\u5f3a\u6548\u6291\u5236\u5242\u4e4b\u524d\u7684\u5242\u91cf\uff08\u5728\u6291\u5236\u5242\u7684<span>3<\/span>\uff5e<span>5<\/span>\u4e2a\u534a\u8870\u671f\u540e\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e5d\u3001\u963f\u8d1d\u897f\u5229 <span>Abemaciclib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>50mg<\/span>\u3001<span>100mg<\/span>\u3001<span>150mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">HR<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9633\u6027\u3001<span>HER2<\/span>\u9634\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff1a\uff08<span>1<\/span>\uff09\u4e0e\u82b3\u9999\u5316\u9176\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\u4f5c\u4e3a\u7edd\u7ecf\u540e\u5973\u6027\u60a3\u8005\u7684\u521d\u59cb\u5185\u5206\u6ccc\u6cbb\u7597\u3002\uff08<span>2<\/span>\uff09\u4e0e\u6c1f\u7ef4\u53f8\u7fa4\u8054\u5408\u7528\u4e8e\u65e2\u5f80\u66fe\u63a5\u53d7\u5185\u5206\u6ccc\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5728\u63a5\u53d7\u963f\u8d1d\u897f\u5229\u6cbb\u7597\u524d\uff0c\u5e94\u5728\u6709\u8d44\u8d28\u7684\u75c5\u7406\u5b9e\u9a8c\u5ba4\u8fdb\u884c\u68c0\u6d4b\u8bc1\u5b9e<span>HR<\/span>\u9633\u6027\u3001<span>HER2<\/span>\u9634\u6027\u60a3\u8005\u65b9\u53ef\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u963f\u8d1d\u897f\u5229\u6cbb\u7597\u5e94\u8be5\u7531\u5177\u6709\u6297\u80bf\u7624\u6cbb\u7597\u7ecf\u9a8c\u7684\u533b\u5e08\u8d77\u59cb\u4f7f\u7528\u5e76\u8fdb\u884c\u6cbb\u7597\u671f\u95f4\u7684\u76d1\u6d4b\u3002\u963f\u8d1d\u897f\u5229\u4e0e\u5185\u5206\u6ccc\u6cbb\u7597\u8054\u5408\u4f7f\u7528\u65f6\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>150mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\u3002\u5982\u679c\u60a3\u8005\u5455\u5410\u6216\u6f0f\u670d\u67d0\u4e00\u6b21\u963f\u8d1d\u897f\u5229\uff0c\u4e0d\u5e94\u8865\u670d\uff0c\u4e0b\u4e00\u6b21\u670d\u836f\u65f6\u95f4\u6309\u8ba1\u5212\u670d\u836f\u5373\u53ef\u3002\u963f\u8d1d\u897f\u5229\u53ef\u5728\u7a7a\u8179\u6216\u8fdb\u98df\u60c5\u51b5\u4e0b\u7ed9\u836f\u3002\u963f\u8d1d\u897f\u5229\u4e0d\u5e94\u968f\u8461\u8404\u67da\u6216\u8461\u8404\u67da\u6c41\u540c\u670d\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u5ea6\uff08<span>Child<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">&#8211;<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">Pugh A<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\uff09\u6216\u4e2d\u5ea6\uff08<span>Child<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">&#8211;<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">Pugh B<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\uff09\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u987b\u8c03\u6574\u5242\u91cf\uff1b\u91cd\u5ea6\uff08<span>Child<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">&#8211;<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">Pugh C<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\uff09\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5efa\u8bae\u964d\u4f4e\u7ed9\u836f\u9891\u7387\u81f3\u6bcf\u5929<span>1<\/span>\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u5728\u4ee5\u4e0b\u65f6\u95f4\u76d1\u6d4b\u5168\u8840\u7ec6\u80de\u8ba1\u6570\uff0c\u5305\u62ec\uff1a\u5f00\u59cb\u963f\u8d1d\u897f\u5229\u6cbb\u7597\u4e4b\u524d\u3001\u6cbb\u7597\u6700\u521d<span>2<\/span>\u4e2a\u6708\u5185\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\u3001\u63a5\u4e0b\u6765<span>2<\/span>\u4e2a\u6708\u5185\u6bcf\u6708\u4e00\u6b21\u4ee5\u53ca\u51fa\u73b0\u4e34\u5e8a\u6307\u5f81\u65f6\u3002\u5728\u5f00\u59cb\u6cbb\u7597\u524d\uff0c\u5efa\u8bae\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u8ba1\u6570\u5e94<span>\u22651.5<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u3001\u8840\u5c0f\u677f\u8ba1\u6570\u5e94<span>\u2265100<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u4e14\u8840\u7ea2\u86cb\u767d\u5e94<span>\u226580g\/L<\/span>\u3002\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u7ecf\u5e38\u88ab\u62a5\u544a\uff0c\u6cbb\u7597\u5f00\u59cb\u81f3<span>3<\/span>\u7ea7\u6216<span>4<\/span>\u7ea7\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u53d1\u751f\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a<span>29<\/span>\uff5e<span>33<\/span>\u5929\uff0c\u81f3\u7f13\u89e3\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a<span>11<\/span>\uff5e<span>15<\/span>\u5929\u3002\u5bf9\u4e8e\u53d1\u751f<span>3<\/span>\u7ea7\u6216<span>4<\/span>\u7ea7\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u7684\u60a3\u8005\uff0c\u5efa\u8bae\u6682\u505c\u7ed9\u836f\uff0c\u76f4\u81f3\u6bd2\u6027\u964d\u4f4e\u81f3<span>2<\/span>\u7ea7\u6216\u4ee5\u4e0b\u3002\u91cd\u65b0\u7ed9\u836f\u65f6\u8003\u8651\u662f\u5426\u9700\u8981\u964d\u4f4e\u5242\u91cf\u3002<\/span><u><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/u>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5e38\u89c1\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u8179\u6cfb\uff0c\u53d1\u751f\u7387\u5728\u6cbb\u7597\u7684\u7b2c<span>1<\/span>\u4e2a\u6708\u5185\u6700\u9ad8\uff0c\u968f\u540e\u964d\u4f4e\u3002\u5728\u5404\u9879\u7814\u7a76\u4e2d\uff0c\u6cbb\u7597\u5f00\u59cb\u81f3\u9996\u6b21\u8179\u6cfb\u4e8b\u4ef6\u53d1\u751f\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a<span>6<\/span>\uff5e<span>8<\/span>\u5929\uff0c\u8179\u6cfb\u6301\u7eed\u4e2d\u4f4d\u65f6\u95f4\u4e3a<span>9<\/span>\uff5e<span>12<\/span>\u5929\uff08<span>2<\/span>\u7ea7\uff09\u548c<span>6<\/span>\uff5e<span>8<\/span>\u5929\uff08<span>3<\/span>\u7ea7\uff09\u3002\u901a\u8fc7\u652f\u6301\u6cbb\u7597\uff08\u4f8b\u5982\u6d1b\u54cc\u4e01\u80fa\uff09\u548c<span>\/<\/span>\u6216\u8c03\u6574\u5242\u91cf\uff0c\u8179\u6cfb\u53ef\u7f13\u89e3\u81f3\u57fa\u7ebf\u6216\u8f83\u4f4e\u7ea7\u522b\u3002\u5982\u679c\u53d1\u751f\u8179\u6cfb\uff0c\u5e94\u5f53\u5c3d\u65e9\u91c7\u53d6\u652f\u6301\u6027\u63aa\u65bd\u3002\u8fd9\u4e9b\u63aa\u65bd\u5305\u62ec\u4ee5\u4e0b\uff1a\u5728\u9996\u6b21\u51fa\u73b0\u7a00\u4fbf\u75c7\u72b6\u65f6\uff0c\u60a3\u8005\u5e94\u5f53\u5f00\u59cb\u6297\u8179\u6cfb\u6cbb\u7597\u3002\u9f13\u52b1\u60a3\u8005\u996e\u7528\u6db2\u4f53\uff08\u4f8b\u5982\uff0c\u6bcf\u5929<span>8<\/span>\uff5e<span>10<\/span>\u676f\u767d\u5f00\u6c34\uff09\u3002\u5982\u679c\u63a5\u53d7\u6297\u8179\u6cfb\u6cbb\u7597\u540e\uff0c\u8179\u6cfb\u672a\u80fd\u5728<span>24<\/span>\u5c0f\u65f6\u5185\u7f13\u89e3\u81f3\u81f3\u5c11<span>1<\/span>\u7ea7\uff0c\u5219\u5e94\u5f53\u6682\u505c\u836f\u7269\uff0c\u76f4\u81f3\u8179\u6cfb\u7f13\u89e3\u81f3\u81f3\u5c11<span>1<\/span>\u7ea7\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5e94\u907f\u514d\u5408\u5e76\u4f7f\u7528\u5f3a\u6548<span>CYP3A4<\/span>\u6291\u5236\u5242\u3002\u5982\u679c\u4e0d\u80fd\u907f\u514d\u4f7f\u7528\u5f3a\u6548<span>CYP3A4<\/span>\u6291\u5236\u5242\uff0c\u963f\u8d1d\u897f\u5229\u7684\u5242\u91cf\u5e94\u964d\u4f4e\u81f3<span>100mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\u3002\u5982\u679c\u7ec8\u6b62<span>CYP3A4<\/span>\u6291\u5236\u5242\u6cbb\u7597\uff0c\u963f\u8d1d\u897f\u5229\u5242\u91cf\u5e94\u5347\u9ad8\u81f3\u5f00\u59cb<span>CYP3A4<\/span>\u6291\u5236\u5242\u6cbb\u7597\u524d\u6240\u4f7f\u7528\u7684\u5242\u91cf\uff08\u5728\u8be5<span>CYP3A4<\/span>\u6291\u5236\u5242\u7684<span>3<\/span>\uff5e<span>5<\/span>\u4e2a\u534a\u8870\u671f\u4e4b\u540e\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5341\u3001\u897f\u8fbe\u672c\u80fa<span> Chidamide<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>5mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8054\u5408\u82b3\u9999\u5316\u9176\u6291\u5236\u5242\u7528\u4e8e<span>HR<\/span>\u9633\u6027\u3001<span>HER2<\/span>\u9634\u6027\u3001\u7edd\u7ecf\u540e\u3001\u7ecf\u5185\u5206\u6ccc\u6cbb\u7597\u590d\u53d1\u6216\u8fdb\u5c55\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u63a5\u53d7\u897f\u8fbe\u672c\u80fa\u6cbb\u7597\u524d\uff0c\u7ecf\u75c5\u7406\u5b66\u8bc1\u5b9e<span>HR<\/span>\u9633\u6027\u3001<span>HER2<\/span>\u9634\u6027\u60a3\u8005\u65b9\u53ef\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u8d77\u59cb\u5242\u91cf\u662f\u6bcf\u6b21\u670d\u836f<span>30mg<\/span>\uff0c\u6bcf\u5468\u670d\u836f\u4e24\u6b21\uff0c\u4e24\u6b21\u670d\u836f\u95f4\u9694\u4e0d\u5e94\u5c11\u4e8e<span>3<\/span>\u5929\uff08\u5982\u5468\u4e00\u548c\u5468\u56db\u3001\u5468\u4e8c\u548c\u5468\u4e94\u3001\u5468\u4e09\u548c\u5468\u516d\u7b49\uff09\u3002\u6bcf<span>4<\/span>\u5468\u4e3a\u4e00\u4e2a\u7528\u836f\u5468\u671f\u3002\u82e5\u75c5\u60c5\u672a\u8fdb\u5c55\u6216\u672a\u51fa\u73b0\u4e0d\u80fd\u8010\u53d7\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5efa\u8bae\u6301\u7eed\u670d\u836f\u3002\u9910\u540e<span>30<\/span>\u5206\u949f\u670d\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u4e3b\u8981\u662f\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94\uff0c\u56e0\u6b64\u5efa\u8bae\u5728\u4f7f\u7528\u672c\u54c1\u524d\u884c\u8840\u5e38\u89c4\u68c0\u67e5\uff0c\u6307\u6807\u6ee1\u8db3\u4ee5\u4e0b\u6761\u4ef6\u65b9\u53ef\u5f00\u59cb\u7528\u836f\uff1a\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u503c\u2265<span>1.5<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff0c\u8840\u5c0f\u677f\u2265<span>75<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff0c\u8840\u7ea2\u86cb\u767d\u2265<span>90g\/L<\/span>\u3002\u7528\u836f\u671f\u95f4\u9700\u5b9a\u671f\u68c0\u6d4b\u8840\u5e38\u89c4\uff08\u901a\u5e38\u4e3a\u6bcf\u5468\u4e00\u6b21\uff09\u3002\u5f53\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94\u4e25\u91cd\u7a0b\u5ea6\u8fbe\u5230<span>3<\/span>\u7ea7\u6216<span>4<\/span>\u7ea7\u65f6\uff0c\u5e94\u6682\u505c\u672c\u54c1\u7528\u836f\u3002\u5f85\u6307\u6807\u6062\u590d\u81f3\u670d\u836f\u524d\u6c34\u5e73\u65f6\uff0c\u7ecf\u8fc7\u8fde\u7eed\u4e24\u6b21\u68c0\u67e5\u786e\u8ba4\uff0c\u53ef\u7ee7\u7eed\u672c\u54c1\u6cbb\u7597\u3002\u6062\u590d\u7528\u836f\u65f6\u7684\u5242\u91cf\u5982\u4e0b\uff1a\u5982\u4e4b\u524d\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a<span>3<\/span>\u7ea7\uff0c\u6062\u590d\u7528\u836f\u65f6\u53ef\u91c7\u7528\u539f\u5242\u91cf\u6216\u5242\u91cf\u964d\u4f4e\u81f3<span>20mg\/<\/span>\u6b21\uff1b\u5982\u4e4b\u524d\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a<span>4<\/span>\u7ea7\uff0c\u6062\u590d\u7528\u836f\u65f6\u5242\u91cf\u5e94\u964d\u4f4e\u81f3<span>20mg\/<\/span>\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u4e34\u5e8a\u76f8\u5173\u6d53\u5ea6\u4e0b\uff0c\u897f\u8fbe\u672c\u80fa\u5bf9\u4eba\u809d\u5fae\u7c92\u4f53<span>CYP450<\/span>\u9176\u4e3b\u8981\u4e9a\u578b\u65e0\u660e\u663e\u6291\u5236\u6216\u8bf1\u5bfc\u4f5c\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\"><br \/>\n<\/span> <\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ae\u80a4\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u4e00\u3001\u4f0a\u9a6c\u66ff\u5c3c<span> Imatinib<\/span><\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08<span>1<\/span>\uff09\u7247\u5242\uff1a<span>100mg<\/span>\u3001<span>400mg<\/span>\uff1b\uff08<span>2<\/span>\uff09\u80f6\u56ca\uff1a<span>50mg<\/span>\u3001<span>100mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5bf9\u4e0d\u80fd\u5207\u9664\u548c<span>\/<\/span>\u6216\u8f6c\u79fb\u6027<span>KIT<\/span>\u7a81\u53d8\u7684\u6076\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u7ecf\u7531\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u786e\u5b9a\u80bf\u7624\u4e3a<span>C-KIT<\/span>\u7a81\u53d8\u9633\u6027\uff0c\u624d\u53ef\u4f7f\u7528\u4f0a\u9a6c\u66ff\u5c3c\u6cbb\u7597\uff0c\u514d\u75ab\u7ec4\u5316<span>CD117<\/span>\u9633\u6027\u4e0d\u80fd\u66ff\u4ee3<span>KIT<\/span>\u7a81\u53d8\u57fa\u56e0\u68c0\u6d4b\uff0c\u4f0a\u9a6c\u66ff\u5c3c\u4e0d\u80fd\u7528\u4e8e<span>KIT<\/span>\u91ce\u751f\u578b\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e<span>KIT<\/span>\u7a81\u53d8\u7684\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>400mg<\/span>\uff1b<span>400mg<\/span>\u6cbb\u7597\u8fdb\u5c55\u540e\u53ef\u9075\u533b\u5631\u589e\u91cf\u81f3<span>600mg<\/span>\u3001<span>800mg<\/span>\uff0c\u4ecd\u6709\u90e8\u5206\u60a3\u8005\u83b7\u76ca\uff0c\u4f46\u4e0d\u826f\u53cd\u5e94\u4ea6\u52a0\u91cd\u3002<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5e38\u89c1\u7684\u53cd\u5e94\u5305\u62ec\u6c34\u80bf\u3001\u4e4f\u529b\u3001\u98df\u6b32\u51cf\u9000\u3001\u76ae\u75b9\u3001\u7c92\u7ec6\u80de\u4e0b\u964d\u7b49\uff0c\u670d\u836f\u671f\u95f4\u5e94\u5b9a\u671f\u68c0\u6d4b\u8840\u5e38\u89c4\u3001\u809d\u80be\u529f\u80fd\u3002<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u662f<span>CYP3A4<\/span>\u7684\u5e95\u7269\uff0c\u540c\u65f6\u7ed9\u4e88<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u540e\u4f0a\u9a6c\u66ff\u5c3c\u7684\u8840\u6d46\u6d53\u5ea6\u964d\u4f4e\uff0c\u4ece\u800c\u5bfc\u81f4\u7597\u6548\u51cf\u4f4e\uff0c\u5e94\u907f\u514d\u4f0a\u9a6c\u66ff\u5c3c\u4e0e<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u540c\u65f6\u670d\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u4f0a\u9a6c\u66ff\u5c3c\u5e94\u5728\u8fdb\u9910\u65f6\u670d\u7528\uff0c\u5e76\u996e\u4e00\u5927\u676f\u6c34\u3002\u5e76\u6ce8\u610f\uff1a\uff08<span>1<\/span>\uff09\u4f7f\u7528\u80f6\u56ca\u5242\u578b\u65f6\uff0c\u5bf9\u4e8e\u4e0d\u80fd\u541e\u54bd\u80f6\u56ca\u7684\u60a3\u8005\uff08\u5305\u62ec\u513f\u7ae5\uff09\uff0c\u53ef\u4ee5\u5c06\u80f6\u56ca\u5185\u836f\u7269\u5206\u6563\u4e8e\u6c34\u6216\u82f9\u679c\u6c41\u4e2d\u3002\u4f7f\u7528\u7247\u5242\u65f6\uff0c\u53ef\u4ee5\u5c06\u836f\u7247\u5206\u6563\u4e8e\u4e0d\u542b\u6c14\u4f53\u7684\u6c34\u6216\u82f9\u679c\u6c41\u4e2d\uff08<span>100mg<\/span>\u7247\u7ea6\u7528<span>50ml<\/span>\uff0c<span>400mg<\/span>\u7ea6\u7528<span>200ml<\/span>\uff09\u3002\u5e94\u6405\u62cc\u6df7\u60ac\u6db2\uff0c\u4e00\u65e6\u836f\u7247\u5d29\u89e3\u5b8c\u5168\u5e94\u7acb\u5373\u670d\u7528\u3002\uff08<span>2<\/span>\uff09\u5982\u679c\u63a5\u53d7\u4f0a\u9a6c\u66ff\u5c3c\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u51fa\u73b0\u4e25\u91cd\u975e\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94\uff08\u5982\u4e25\u91cd\u4f53\u6db2\u6f74\u7559\uff09\uff0c\u5e94\u505c\u836f\uff0c\u76f4\u5230\u4e0d\u826f\u53cd\u5e94\u6d88\u5931\uff0c\u7136\u540e\u518d\u6839\u636e\u8be5\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\u8c03\u6574\u5242\u91cf\u3002\uff08<span>3<\/span>\uff09\u5bf9\u4e8e<span>3<\/span>\u5c81\u4ee5\u4e0a\u513f\u7ae5\u4f7f\u7528\u4f0a\u9a6c\u66ff\u5c3c\u7684\u7814\u7a76\uff0c\u4e3b\u8981\u6765\u81ea\u56fd\u5916\u513f\u7ae5\u7814\u7a76\u6570\u636e\uff0c\u4e2d\u56fd\u513f\u7ae5\u4eba\u7fa4\u7528\u836f\u5b89\u5168\u6709\u6548\u6027\u6570\u636e\u6709\u9650\u3002\u5c1a\u65e0<span>3<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u7528\u836f\u7ecf\u9a8c\u3002\uff08<span>4<\/span>\uff09\u5df2\u6709\u62a5\u544a\u663e\u793a\u63a5\u53d7\u4f0a\u9a6c\u66ff\u5c3c\u7684\u513f\u7ae5\u548c\u9752\u6625\u524d\u671f\u9752\u5c11\u5e74\u51fa\u73b0\u53d1\u80b2\u8fdf\u7f13\u3002\u6682\u4e0d\u77e5\u4f0a\u9a6c\u66ff\u5c3c\u5ef6\u957f\u6cbb\u7597\u5bf9\u513f\u7ae5\u53d1\u80b2\u7684\u957f\u671f\u5f71\u54cd\u3002\u56e0\u6b64\uff0c\u5efa\u8bae\u5bf9\u4f7f\u7528\u4f0a\u9a6c\u66ff\u5c3c\u7684\u513f\u7ae5\u7684\u53d1\u80b2\u60c5\u51b5\u8fdb\u884c\u5bc6\u5207\u76d1\u6d4b\u3002<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u4e8c\u3001<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u7ef4\u83ab\u975e\u5c3c<span> Vemurafenib<\/span><\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c<\/span><\/b><b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">240mg<\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u786e\u5b9a\u7684<span>BRAF V600<\/span>\u7a81\u53d8\u9633\u6027\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d\u5fc5\u987b\u7ecf\u7531\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u786e\u5b9a\u80bf\u7624\u4e3a<span>BRAF V600<\/span>\u7a81\u53d8\u9633\u6027\uff0c\u624d\u53ef\u4f7f\u7528\u7ef4\u83ab\u975e\u5c3c\u6cbb\u7597\uff0c\u7ef4\u83ab\u975e\u5c3c\u4e0d\u80fd\u7528\u4e8e<span>BRAF<\/span>\u91ce\u751f\u578b\u9ed1\u8272\u7d20\u7624\u60a3\u8005<i>\u3002<\/i><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:26.85pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ef4\u83ab\u975e\u5c3c\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>960mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\uff08<span>1920mg<\/span>\u6bcf\u5929\u603b\u5242\u91cf\uff09\uff0c\u4e0d\u63a8\u8350\u5c06\u5242\u91cf\u51cf\u81f3\u4f4e\u4e8e<span>480mg<\/span>\uff0c\u6bcf\u5929\u4e24\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:26.85pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u76ae\u80a4\u53cd\u5e94\u5982\u76ae\u75b9\uff0c\u5149\u654f\u53cd\u5e94\u7b49<i>\u3002<\/i><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u7ebf<span>QTc<\/span>\uff1e<span>500ms<\/span>\u65f6\u4e0d\u5efa\u8bae\u5f00\u59cb\u670d\u7528\u7ef4\u83ab\u975e\u5c3c\uff0c\u5bf9\u4e8e\u5b58\u5728\u65e0\u6cd5\u7ea0\u6b63\u7684\u7535\u89e3\u8d28\u5f02\u5e38\u3001\u957f<span>QTc<\/span>\u7efc\u5408\u5f81\u6216\u6b63\u5728\u670d\u7528\u5df2\u77e5\u80fd\u5ef6\u957f<span>QTc<\/span>\u95f4\u671f\u7684\u836f\u7269\u7684\u60a3\u8005\uff0c\u4e0d\u5efa\u8bae\u63a5\u53d7\u7ef4\u83ab\u975e\u5c3c\u6cbb\u7597<i>\u3002<\/i><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ca1\u6709\u8bc1\u636e\u8868\u660e\u7ef4\u83ab\u975e\u5c3c\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\u53ef\u4ee5\u589e\u6548\uff0c\u4f7f\u7528\u7ef4\u83ab\u975e\u5c3c\u65f6\u4e0d\u5efa\u8bae\u4e0e\u4f0a\u5339\u6728\u5355\u6297\u8054\u5408\u7528\u836f<i>\u3002<\/i><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u598a\u5a20\u671f\u5987\u5973\u7981\u6b62\u4f7f\u7528\u7ef4\u83ab\u975e\u5c3c\uff0c\u9664\u975e\u5bf9\u4e8e\u6bcd\u4eb2\u7684\u53ef\u80fd\u53d7\u76ca\u8d85\u8fc7\u5bf9\u80ce\u513f\u7684\u53ef\u80fd\u98ce\u9669\u3002\u4e0d\u5efa\u8bae\u54fa\u4e73\u671f\u5987\u5973\u4f7f\u7528\u7ef4\u83ab\u975e\u5c3c\uff0c\u5fc5\u987b\u5728\u6743\u8861\u54fa\u4e73\u5582\u517b\u5bf9\u5a74\u513f\u7684\u76ca\u5904\u4ee5\u53ca\u6cbb\u7597\u5bf9\u6bcd\u4eb2\u7684\u76ca\u5904\u4e4b\u540e\uff0c\u505a\u51fa\u662f\u5426\u505c\u6b62\u6bcd\u4e73\u5582\u517b\u6216\u505c\u6b62\u7ef4\u83ab\u975e\u5c3c\u6cbb\u7597\u7684\u51b3\u5b9a<i>\u3002<\/i><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4f7f\u7528\u7ef4\u83ab\u975e\u5c3c\u65f6\u4e0d\u5efa\u8bae\u4e0e\u7ecf<span>CYP1A2<\/span>\u548c<span>CYP3A4<\/span>\u4ee3\u8c22\u3001\u4e14\u5b89\u5168\u6cbb\u7597\u7a97\u8f83\u7a84\u7684\u836f\u7269\u8054\u5408\u5e94\u7528\uff0c\u4f7f\u7528\u7ef4\u83ab\u975e\u5c3c\u65f6\u614e\u7528\u5f3a\u6548<span>CYP3A4<\/span>\u6291\u5236\u5242\u6216\u8bf1\u5bfc\u5242\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e09\u3001\u8fbe\u62c9\u975e\u5c3c<span> Dabrafenib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>50mg<\/span>\u3001<span>75mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fbe\u62c9\u975e\u5c3c\u8054\u5408\u66f2\u7f8e\u66ff\u5c3c\u9002\u7528\u4e8e\u6cbb\u7597<span>BRAF V600<\/span>\u7a81\u53d8\u9633\u6027\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fbe\u62c9\u975e\u5c3c\u8054\u5408\u66f2\u7f8e\u66ff\u5c3c\u9002\u7528\u4e8e<span>BRAF V600<\/span>\u7a81\u53d8\u9633\u6027\u7684\u2162\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u5b8c\u5168\u5207\u9664\u540e\u7684\u8f85\u52a9\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u8054\u5408\u66f2\u7f8e\u66ff\u5c3c\u6cbb\u7597\u524d\u987b\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u8fdb\u884c<span>BRAF V600<\/span>\u7a81\u53d8\u68c0\u6d4b\uff0c\u786e\u8ba4\u4e3a<span>BRAF V600<\/span>\u7a81\u53d8\u9633\u6027\u7684\u60a3\u8005\u65b9\u53ef\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u3002\u672c\u54c1\u8054\u5408\u66f2\u7f8e\u66ff\u5c3c\u4e0d\u9002\u7528\u4e8e<span>BRAF<\/span>\u91ce\u751f\u578b\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fbe\u62c9\u975e\u5c3c\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>150mg<\/span>\u6bcf\u5929\u4e24\u6b21\uff08<span>300mg<\/span>\u6bcf\u5929\u603b\u5242\u91cf\uff09\u3002\u672c\u54c1\u9700\u8054\u5408\u66f2\u7f8e\u66ff\u5c3c\u6cbb\u7597\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fbe\u62c9\u975e\u5c3c\u5e94\u5728\u9910\u524d\u81f3\u5c11<span>1<\/span>\u5c0f\u65f6\u524d\u6216\u9910\u540e\u81f3\u5c11<span>2<\/span>\u5c0f\u65f6\u540e\u670d\u7528\uff0c\u7ed9\u836f\u95f4\u9694\u7ea6<span>12<\/span>\u5c0f\u65f6\u3002\u5e94\u5728\u6bcf\u5929\u76f8\u540c\u65f6\u95f4\u670d\u7528\u672c\u54c1\uff0c\u5982\u679c\u9519\u8fc7\u4e00\u5242\u8fbe\u62c9\u975e\u5c3c\uff0c\u4e14\u8ddd\u4e0b\u4e00\u6b21\u670d\u836f\u65f6\u95f4\u4e0d\u8db3<span>6<\/span>\u5c0f\u65f6\uff0c\u5219\u4e0d\u5e94\u8865\u670d\u3002\u5f53\u8fbe\u62c9\u975e\u5c3c\u8054\u5408\u5e94\u7528\u66f2\u7f8e\u66ff\u5c3c\u65f6\uff0c\u5e94\u5728\u6bcf\u5929\u76f8\u540c\u65f6\u95f4\u670d\u7528\u66f2\u7f8e\u66ff\u5c3c\u6bcf\u5929\u4e00\u6b21\uff0c\u4e0e\u5728\u65e9\u6668\u6216\u665a\u4e0a\u7ed9\u836f\u7684\u8fbe\u62c9\u975e\u5c3c\u4e00\u8d77\u670d\u7528\u3002\u8bf7\u52ff\u6253\u5f00\u3001\u538b\u788e\u6216\u63b0\u65ad\u8fbe\u62c9\u975e\u5c3c\u80f6\u56ca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u7ed9\u4e88\u8fbe\u62c9\u975e\u5c3c\u8054\u5408\u5e94\u7528\u66f2\u7f8e\u66ff\u5c3c\u6cbb\u7597\u65f6\uff0c\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\uff1a\u53d1\u70ed\u3001\u5bd2\u6218\u3001\u76ae\u75b9\u3001\u5934\u75db\u3001\u5934\u6655\u3001\u5173\u8282\u75db\u3001\u54b3\u55fd\u7b49\u3002\u5982\u679c\u51fa\u73b0\u6cbb\u7597\u76f8\u5173\u7684\u6bd2\u6027\uff0c\u5219\u4e24\u79cd\u6cbb\u7597\u5e94\u540c\u65f6\u8fdb\u884c\u5242\u91cf\u51cf\u5c11\u3001\u4e2d\u65ad\u6216\u505c\u6b62\u3002\u5982\u679c\u51fa\u73b0\u4e0e\u8fbe\u62c9\u975e\u5c3c\u76f8\u5173\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u8461\u8404\u819c\u708e\u3001\u975e\u76ae\u80a4\u6076\u6027\u80bf\u7624\uff09\uff0c\u4ec5\u9700\u5bf9\u8fbe\u62c9\u975e\u5c3c\u6cbb\u7597\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u3001\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u9996\u6b21\u6cbb\u7597\u65f6\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u5e94\u614e\u7528\u8fbe\u62c9\u975e\u5c3c\u3002\u8001\u5e74\u60a3\u8005\uff08\u2265<span>65<\/span>\u5c81\uff09\u65e0\u9700\u8c03\u6574\u521d\u59cb\u5242\u91cf\u3002\u5c1a\u672a\u786e\u5b9a\u8fbe\u62c9\u975e\u5c3c\u5728\u513f\u7ae5\u548c\u9752\u5c11\u5e74\uff08\uff1c<span>18<\/span>\u5c81\uff09\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.CYP2C8<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6216<span>CYP3A4<\/span>\u5f3a\u6548\u6291\u5236\u5242\u6216\u8bf1\u5bfc\u5242\u7684\u836f\u7269\u53ef\u80fd\u5f71\u54cd\u8fbe\u62c9\u975e\u5c3c\u7684\u8840\u836f\u6d53\u5ea6\u3002\u53ef\u80fd\u60c5\u51b5\u4e0b\uff0c\u63a5\u53d7\u8fbe\u62c9\u975e\u5c3c\u6cbb\u7597\u65f6\u5e94\u8003\u8651\u66ff\u4ee3\u73b0\u6709\u670d\u7528\u836f\u7269\u4e2d<span>CYP2C8<\/span>\u548c<span>CYP3A4<\/span>\u7684\u6291\u5236\u5242\u6216\u8bf1\u5bfc\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u7f8e\u56fd\u548c\u6b27\u76df\uff0c\u8fbe\u62c9\u975e\u5c3c\u8054\u5408\u66f2\u7f8e\u66ff\u5c3c\u5206\u522b\u83b7\u6279\u7528\u4e8e<span>BRAF V600E<\/span>\u548c<span>BRAF V600<\/span>\u7a81\u53d8\u7684\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u6cbb\u7597\u3002\u5728\u7f8e\u56fd\uff0c\u8fbe\u62c9\u975e\u5c3c\u8054\u5408\u66f2\u7f8e\u66ff\u5c3c\u83b7\u6279\u7528\u4e8e<span>BRAF V600E<\/span>\u7a81\u53d8\u7684\u5c40\u665a\u671f\u6216\u8f6c\u79fb\u6027\u7532\u72b6\u817a\u672a\u5206\u5316\u764c\u6cbb\u7597\u3002\u76ee\u524d\u8fd9\u4e24\u4e2a\u9002\u5e94\u8bc1\u5728\u4e2d\u56fd\u5c1a\u672a\u83b7\u6279\uff0c\u53ef\u5728\u4e0e\u60a3\u8005\u5145\u5206\u6c9f\u901a\u7684\u60c5\u51b5\u4e0b\u4f7f\u7528\u3002\u5728\u7f8e\u56fd\uff0c\u63a8\u8350\u5242\u91cf\u4e3a\u8fbe\u62c9\u975e\u5c3c<span>150mg<\/span>\u6bcf\u5929\u4e24\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56db\u3001\u66f2\u7f8e\u66ff\u5c3c<span> Trametinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>0.5mg<\/span>\u3001<span>2mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66f2\u7f8e\u66ff\u5c3c\u8054\u5408\u8fbe\u62c9\u975e\u5c3c\u9002\u7528\u4e8e\u6cbb\u7597<span>BRAF V600<\/span>\u7a81\u53d8\u9633\u6027\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66f2\u7f8e\u66ff\u5c3c\u8054\u5408\u8fbe\u62c9\u975e\u5c3c\u9002\u7528\u4e8e<span>BRAF V600<\/span>\u7a81\u53d8\u9633\u6027\u7684\u2162\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u5b8c\u5168\u5207\u9664\u540e\u7684\u8f85\u52a9\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66f2\u7f8e\u66ff\u5c3c\u8054\u5408\u8fbe\u62c9\u975e\u5c3c\u6cbb\u7597\u524d\u987b\u7ecf\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u8fdb\u884c<span>BRAF V600<\/span>\u7a81\u53d8\u68c0\u6d4b\uff0c\u786e\u8ba4\u4e3a<span>BRAF V600<\/span>\u7a81\u53d8\u9633\u6027\u7684\u60a3\u8005\u65b9\u53ef\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u3002\u672c\u54c1\u8054\u5408\u8fbe\u62c9\u975e\u5c3c\u4e0d\u9002\u7528\u4e8e<span>BRAF<\/span>\u91ce\u751f\u578b\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66f2\u7f8e\u66ff\u5c3c\u7684\u63a8\u8350\u5242\u91cf\u662f<span>2mg<\/span>\u6bcf\u5929\u4e00\u6b21\u53e3\u670d\uff0c\u9700\u8054\u5408\u8fbe\u62c9\u975e\u5c3c\u6cbb\u7597\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u53cd\u5e94\u3002\u9996\u6b21\u5242\u91cf\u51cf\u5c11\uff0c\u6bcf\u5929\u4e00\u6b21<span>1.5mg<\/span>\uff1b\u7b2c\u4e8c\u6b21\u51cf\u91cf\uff0c\u6bcf\u5929\u4e00\u6b21<span>1mg<\/span>\uff1b\u5982\u679c\u4e0d\u80fd\u8010\u53d7\u6bcf\u5929\u4e00\u6b21<span>1mg<\/span>\uff0c\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u66f2\u7f8e\u66ff\u5c3c\u5e94\u5728\u9910\u524d\u81f3\u5c11<span>1<\/span>\u5c0f\u65f6\u524d\u6216\u9910\u540e\u81f3\u5c11<span>2<\/span>\u5c0f\u65f6\u540e\u670d\u7528\u3002\u5e94\u5728\u6bcf\u5929\u76f8\u540c\u65f6\u95f4\u670d\u7528\u66f2\u7f8e\u66ff\u5c3c\u3002\u5982\u679c\u9519\u8fc7\u4e00\u5242\u672c\u54c1\uff0c\u987b\u6700\u665a\u5728\u9884\u5b9a\u7684\u4e0b\u4e00\u6b21\u7ed9\u836f\u4e4b\u524d<span>12<\/span>\u5c0f\u65f6\u8865\u4e0a\u3002\u5982\u679c\u8ddd\u79bb\u4e0b\u6b21\u9884\u5b9a\u7684\u7ed9\u836f\u65f6\u95f4\u77ed\u4e8e<span>12<\/span>\u5c0f\u65f6\uff0c\u5219\u4e0d\u5e94\u8be5\u8865\u670d\u3002\u672c\u54c1\u8054\u5408\u8fbe\u62c9\u975e\u5c3c\u65f6\uff0c\u5e94\u5728\u6bcf\u5929\u76f8\u540c\u65f6\u95f4\u670d\u7528\u672c\u54c1\u6bcf\u5929\u4e00\u6b21\uff0c\u4e0e\u5728\u65e9\u6668\u6216\u665a\u4e0a\u7ed9\u836f\u7684\u8fbe\u62c9\u975e\u5c3c\u4e00\u8d77\u670d\u7528\u3002\u4e0d\u5e94\u5480\u56bc\u6216\u538b\u788e\u672c\u54c1\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u7ed9\u4e88\u66f2\u7f8e\u66ff\u5c3c\u8054\u5408\u5e94\u7528\u8fbe\u62c9\u975e\u5c3c\u6cbb\u7597\u65f6\uff0c\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\uff1a\u53d1\u70ed\u3001\u5bd2\u6218\u3001\u76ae\u75b9\u3001\u5934\u75db\u3001\u5934\u6655\u3001\u5173\u8282\u75db\u3001\u54b3\u55fd\u7b49\u3002\u5982\u679c\u51fa\u73b0\u6cbb\u7597\u76f8\u5173\u7684\u6bd2\u6027\uff0c\u5219\u4e24\u79cd\u6cbb\u7597\u5e94\u540c\u65f6\u8fdb\u884c\u5242\u91cf\u51cf\u5c11\u3001\u4e2d\u65ad\u6216\u505c\u6b62\u3002\u5bf9\u4e8e\u4e3b\u8981\u4e0e\u66f2\u7f8e\u66ff\u5c3c\u76f8\u5173\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u89c6\u7f51\u819c\u9759\u8109\u963b\u585e\u3001\u89c6\u7f51\u819c\u8272\u7d20\u4e0a\u76ae\u8131\u79bb\u3001\u95f4\u8d28\u6027\u80ba\u708e\u548c\u5355\u7eaf\u6027\u9759\u8109\u8840\u6813\u6813\u585e\uff09\uff0c\u4ec5\u9700\u5bf9\u66f2\u7f8e\u66ff\u5c3c\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u3001\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u3001\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u5e94\u614e\u7528\u8fbe\u62c9\u975e\u5c3c\u3002\u8001\u5e74\u60a3\u8005\uff08\u2265<span>65<\/span>\u5c81\uff09\u65e0\u9700\u8c03\u6574\u521d\u59cb\u5242\u91cf\u3002\u5c1a\u672a\u786e\u5b9a\u8fbe\u62c9\u975e\u5c3c\u5728\u513f\u7ae5\u548c\u9752\u5c11\u5e74\uff08\uff1c<span>18<\/span>\u5c81\uff09\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ecf\u6c34\u89e3\u9176\u4ee3\u8c22\u7684\u836f\u7269\u53ef\u80fd\u5f71\u54cd\u66f2\u7f8e\u66ff\u5c3c\u66b4\u9732\uff0c\u836f\u7269\u95f4\u76f8\u4e92\u4f5c\u7528\u4e0d\u80fd\u6392\u9664\u3002\u66f2\u7f8e\u66ff\u5c3c\u5e94\u8c28\u614e\u5408\u7528\u5f3a\u6548<span>P-<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u7f8e\u56fd\u548c\u6b27\u76df\uff0c\u66f2\u7f8e\u66ff\u5c3c\u8054\u5408\u8fbe\u62c9\u975e\u5c3c\u5206\u522b\u83b7\u6279\u7528\u4e8e<span>BRAF V600E<\/span>\u548c<span>BRAF V600<\/span>\u7a81\u53d8\u7684\u8f6c\u79fb\u6027<span>NSCLC<\/span>\u6cbb\u7597\u3002\u5728\u7f8e\u56fd\uff0c\u66f2\u7f8e\u66ff\u5c3c\u8054\u5408\u8fbe\u62c9\u975e\u5c3c\u83b7\u6279\u7528\u4e8e<span>BRAF V600E<\/span>\u7a81\u53d8\u7684\u5c40\u665a\u671f\u6216\u8f6c\u79fb\u6027\u7532\u72b6\u817a\u672a\u5206\u5316\u764c\u6cbb\u7597\u3002\u76ee\u524d\u8fd9\u4e24\u4e2a\u9002\u5e94\u8bc1\u5728\u4e2d\u56fd\u5c1a\u672a\u83b7\u6279\uff0c\u53ef\u5728\u4e0e\u60a3\u8005\u5145\u5206\u6c9f\u901a\u7684\u60c5\u51b5\u4e0b\u4f7f\u7528\u3002\u5728\u7f8e\u56fd\uff0c\u63a8\u8350\u5242\u91cf\u4e3a\u66f2\u7f8e\u66ff\u5c3c<span>2mg<\/span>\u6bcf\u5929\u4e00\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e94\u3001\u5e15\u535a\u5229\u73e0\u5355\u6297<span> Pembrolizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>4ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u76ae\u80a4\u578b\u9ed1\u8272\u7d20\u7624\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7ecf\u4e00\u7ebf\u6cbb\u7597\u5931\u8d25\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u63a8\u8350\u7ed9\u836f\u65b9\u6848\u4e3a<span>200mg<\/span>\uff0c\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\u6216\u8005<span>400mg<\/span>\u6bcf<span>6<\/span>\u5468\u4e00\u6b21\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u4f46\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u505c\u836f\uff0c\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e3b\u8981\u4e0d\u826f\u53cd\u5e94\u662f\u75b2\u52b3\u3001\u7619\u75d2\u3001\u8179\u6cfb\u548c\u76ae\u75b9\u3002\u63a5\u53d7\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u53ef\u53d1\u751f\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u4e25\u91cd\u548c\u81f4\u6b7b\u75c5\u4f8b\u3002\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u53ef\u540c\u65f6\u53d1\u751f\u5728\u591a\u4e2a\u5668\u5b98\u7cfb\u7edf\uff0c\u9700\u8981\u5bf9\u4e8e\u7591\u4f3c\u75c5\u4f8b\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u5b9a\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u5e94\u6682\u65f6\u505c\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\uff0c\u5e76\u5e94\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u3002\u5f53\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u6539\u5584\u81f3\u2264<span>1<\/span>\u7ea7\u65f6\uff0c\u9700\u81f3\u5c11\u4e00\u4e2a\u6708\u7684\u65f6\u95f4\u9010\u6b65\u51cf\u5c11\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7684\u7528\u91cf\u76f4\u81f3\u505c\u836f\u3002\u5018\u82e5\u53d1\u751f\u7cd6\u76ae\u8d28\u6fc0\u7d20\u65e0\u6cd5\u63a7\u5236\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u65f6\uff0c\u53ef\u4ee5\u8003\u8651\u4f7f\u7528\u5176\u4ed6\u5168\u8eab\u6027\u514d\u75ab\u6291\u5236\u5242\u3002\u5982\u679c\u4e0d\u826f\u53cd\u5e94\u4fdd\u6301\u5728\u2264<span>1<\/span>\u7ea7\uff0c\u4e14\u7cd6\u76ae\u8d28\u6fc0\u7d20\u5242\u91cf\u5df2\u964d\u81f3\u2264<span>10mg<\/span>\u6cfc\u5c3c\u677e\u6216\u7b49\u6548\u5242\u91cf\uff0c\u53ef\u5728\u6700\u540e\u4e00\u6b21\u4f7f\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ed9\u836f\u540e<span>12<\/span>\u5468\u5185\u91cd\u65b0\u5f00\u59cb\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u3002\u5bf9\u4e8e\u4efb\u4f55\u590d\u53d1\u6027<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u4ee5\u53ca\u4efb\u4f55<span>4<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u6c38\u4e45\u505c\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u51fa\u73b0\u8f7b\u4e2d\u5ea6\u8f93\u6db2\u53cd\u5e94\u7684\u60a3\u8005\u5728\u5bc6\u5207\u76d1\u6d4b\u4e0b\u53ef\u7ee7\u7eed\u63a5\u53d7\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\uff0c\u53ef\u8003\u8651\u7528\u89e3\u70ed\u9547\u75db\u7c7b\u6297\u708e\u836f\u548c\u6297\u7ec4\u80fa\u836f\u9884\u9632\u3002\u5bf9\u4e8e\u91cd\u5ea6\u7684\u8f93\u6db2\u53cd\u5e94\uff0c\u5fc5\u987b\u505c\u6b62\u8f93\u6db2\u5e76\u6c38\u4e45\u505c\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5b55\u5987\u5728\u598a\u5a20\u671f\u4f7f\u7528\u53ef\u80fd\u4f1a\u5bf9\u80ce\u513f\u9020\u6210\u4f24\u5bb3\uff0c\u9664\u975e\u5b55\u5987\u7684\u4e34\u5e8a\u75be\u75c5\u9700\u8981\uff0c\u598a\u5a20\u671f\u4e0d\u5f97\u7528\u836f\u3002\u5efa\u8bae\u80b2\u9f84\u5973\u6027\u5728\u7528\u836f\u671f\u95f4\u91c7\u7528\u9ad8\u6548\u907f\u5b55\u65b9\u6cd5\uff0c\u5e76\u5728\u6700\u540e\u4e00\u6b21\u7528\u836f\u540e\u56db\u4e2a\u6708\u5185\u6301\u7eed\u907f\u5b55\u3002\u4e0d\u80fd\u6392\u9664\u672c\u54c1\u5bf9\u65b0\u751f\u513f\u7684\u98ce\u9669\uff0c\u5e94\u6743\u8861\u54fa\u4e73\u5bf9\u80ce\u513f\u7684\u83b7\u76ca\u4ee5\u53ca\u672c\u54c1\u6cbb\u7597\u5bf9\u5973\u6027\u60a3\u8005\u7684\u83b7\u76ca\u6765\u51b3\u7b56\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5c1a\u672a\u786e\u5b9a<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u4f7f\u7528\u672c\u54c1\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u5728\u8001\u5e74\u4eba\u7fa4\u4e2d\u4e0d\u9700\u8981\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u5c1a\u672a\u5728\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u8fdb\u884c\u672c\u54c1\u7684\u76f8\u5173\u7814\u7a76\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5728\u4f7f\u7528\u8be5\u836f\u524d\u907f\u514d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u516d\u3001\u7279\u745e\u666e\u5229\u5355\u6297<span> Toripalimab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">80mg<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\uff08<span>2ml<\/span>\uff09<span>\/<\/span>\u74f6\u3001<span>240mg<\/span>\uff08<span>6ml<\/span>\uff09<span>\/<\/span>\u74f6<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u9002\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u5168\u8eab\u7cfb\u7edf\u6cbb\u7597\u5931\u8d25\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u9ed1\u8272\u7d20\u7624\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>3mg\/kg<\/span>\uff0c\u9759\u8109\u8f93\u6ce8\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff0c\u76f4\u5230\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u5df2\u89c2\u5bdf\u5230\u90e8\u5206\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u7684\u60a3\u8005\u5b58\u5728\u80bf\u7624\u975e\u5178\u578b\u53cd\u5e94\uff0c\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u5728\u5f71\u50cf\u5b66\u4e0a\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u665a\u671f\u9ecf\u819c\u578b\u9ed1\u8272\u7d20\u7624\uff0c<span>PD-1<\/span>\u5355\u6297\u5355\u836f\u7597\u6548\u6709\u9650\uff0c\u6839\u636e<span>CT13<\/span>\u7814\u7a76\uff0c\u5efa\u8bae\u91c7\u7528\u7279\u745e\u666e\u5229\u5355\u6297\uff08<span>3mg\/kg<\/span>\uff0c\u9759\u8109\u8f93\u6ce8\u6bcf\u4e24\u5468\u4e00\u6b21\uff09\u8054\u5408\u963f\u6614\u66ff\u5c3c\uff08<span>5mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\uff09\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u4e0d\u826f\u53cd\u5e94\u4e3a\u8d2b\u8840\u3001<span>ALT<\/span>\u5347\u9ad8\u3001\u4e4f\u529b\u3001<span>AST<\/span>\u5347\u9ad8\u3001\u76ae\u75b9\u3001\u53d1\u70ed\u3001\u8840\u4fc3\u7532\u72b6\u817a\u6fc0\u7d20\u5347\u9ad8\u3001\u767d\u7ec6\u80de\u8ba1\u6570\u51cf\u5c11\u3001\u54b3\u55fd\u3001\u7619\u75d2\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u75c7\u3001\u98df\u6b32\u4e0b\u964d\u3001\u8840\u7cd6\u5347\u9ad8\u548c\u8840\u80c6\u7ea2\u7d20\u5347\u9ad8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u5927\u591a\u6570\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u662f\u53ef\u9006\u7684\uff0c\u4e14\u53ef\u901a\u8fc7\u4e2d\u65ad\u7279\u745e\u666e\u5229\u5355\u6297\u5e76\u4f7f\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u652f\u6301\u6cbb\u7597\u3002\u5bf9\u4e8e\u5927\u90e8\u5206<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u53ca\u67d0\u4e9b\u7279\u5b9a\u7684<span>2<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u9700\u6682\u505c\u7ed9\u836f\uff0c\u5e76\u7ed9\u4e88<span>1<\/span>\uff5e<span>2mg\/<\/span>\uff08<span>kg<\/span><\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u2022<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">d<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\uff09\u5f3a\u7684\u677e\u7b49\u6548\u5242\u91cf\u53ca\u5176\u4ed6\u6cbb\u7597\uff0c\u76f4\u81f3\u6539\u5584\u5230\u2264<span>1<\/span>\u7ea7\u3002\u7cd6\u76ae\u8d28\u6fc0\u7d20\u9700\u81f3\u5c11\u4e00\u4e2a\u6708\u7684\u65f6\u95f4\u9010\u6e10\u51cf\u91cf\u76f4\u81f3\u505c\u836f\uff0c\u5feb\u901f\u51cf\u91cf\u53ef\u80fd\u5f15\u8d77\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u7684\u53cd\u590d\u3002\u5982\u679c\u4e0d\u826f\u53cd\u5e94\u5728\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u540e\u7ee7\u7eed\u6076\u5316\u6216\u65e0\u6539\u5584\uff0c\u5219\u5e94\u589e\u52a0\u7cd6\u76ae\u8d28\u6fc0\u7d20\u4ee5\u5916\u7684\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e<span>4<\/span>\u7ea7\u53ca\u67d0\u4e9b\u7279\u5b9a\u7684<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ca\u4efb\u4f55\u590d\u53d1\u6027<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u672b\u6b21\u7ed9\u836f\u540e<span>12<\/span>\u5468\u5185<span>2<\/span>\uff5e<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u672a\u6539\u5584\u5230<span>0<\/span>\uff5e<span>1<\/span>\u7ea7\uff08\u9664\u5916\u5185\u5206\u6ccc\u75be\u75c5\uff09\uff0c\u4ee5\u53ca\u672b\u6b21\u7ed9\u836f<span>12<\/span>\u5468\u5185\u7cd6\u76ae\u8d28\u6fc0\u7d20\u672a\u80fd\u964d\u81f3\u2264<span>10mg\/d<\/span>\u5f3a\u7684\u677e\u7b49\u6548\u5242\u91cf\uff0c\u5e94\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\">\u7981\u5fcc\uff1a\uff08<span>1<\/span>\uff09\u7981\u6b62\u7528\u4e8e\u5bf9\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\u6d3b\u6027\u6210\u5206\u6216\u8f85\u6599\u5b58\u5728\u8d85\u654f\u53cd\u5e94\u7684\u60a3\u8005\u3002\uff08<span>2<\/span>\uff09\u4e0d\u53ef\u4e0e\u5176\u4ed6\u836f\u54c1\u6df7\u5408\u6216\u7a00\u91ca\uff0c\u836f\u74f6\u4e2d\u5269\u4f59\u7684\u836f\u7269\u4e0d\u53ef\u91cd\u590d\u4f7f\u7528\u3002\uff08<span>3<\/span>\uff09\u4e0d\u5f97\u91c7\u7528\u9759\u8109\u63a8\u6ce8\u6216\u5355\u6b21\u5feb\u901f\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56e0\u53ef\u80fd\u5e72\u6270\u672c\u54c1\u836f\u6548\u5b66\u6d3b\u6027\uff0c\u5e94\u907f\u514d\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002\u4f46\u662f\u5982\u679c\u4e3a\u4e86\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u540e\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p><b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><br \/>\n<\/span><\/b> <\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9aa8\u4e0e\u8f6f\u7ec4\u7ec7\u80bf\u7624\u7528\u836f<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e00\u3001\u4f9d\u7ef4\u83ab\u53f8<span> Everolimus<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.5mg<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u3001<span>5mg<\/span>\u3001<span>10mg<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9700\u8981\u6cbb\u7597\u5e72\u9884\u4f46\u4e0d\u9002\u4e8e\u624b\u672f\u5207\u9664\u7684\u7ed3\u8282\u6027\u786c\u5316\u75c7\u76f8\u5173\u7684\u5ba4\u7ba1\u819c\u4e0b\u5de8\u7ec6\u80de\u661f\u5f62\u7ec6\u80de\u7624\u6210\u4eba\u548c\u513f\u7ae5\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u6cbb\u7597\u4e0d\u9700\u7acb\u5373\u624b\u672f\u6cbb\u7597\u7684\u7ed3\u8282\u6027\u786c\u5316\u75c7\u76f8\u5173\u7684\u80be\u8840\u7ba1\u5e73\u6ed1\u808c\u8102\u80aa\u7624\u6210\u4eba\u60a3\u8005\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u63a8\u8350\u5242\u91cf\u4e3a<span>10mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\u53e3\u670d\u7ed9\u836f\uff0c\u5728\u6bcf\u4e00\u5929\u540c\u4e00\u65f6\u95f4\u670d\u7528\uff0c\u53ef\u4e0e\u98df\u7269\u540c\u670d\u6216\u4e0d\u4e0e\u98df\u7269\u540c\u65f6\u670d\u7528\uff0c\u4e0d\u5e94\u5480\u56bc\u548c\u538b\u788e\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9057\u6f0f\u5242\u91cf\uff1a\u672c\u54c1\u5728\u6b63\u5e38\u670d\u7528\u65f6\u95f4\u540e<span>6<\/span>\u5c0f\u65f6\u5185\u5747\u53ef\u8865\u670d\u9057\u6f0f\u5242\u91cf\uff0c\u8d85\u8fc7<span>6<\/span>\u5c0f\u65f6\u540e\u5e94\u8df3\u8fc7\u8be5\u5242\u91cf\uff0c\u6b21\u65e5\u6309\u6b63\u5e38\u65f6\u95f4\u670d\u7528\u672c\u54c1\u3002\u4e0d\u53ef\u5c06\u5242\u91cf\u7ffb\u500d\u4ee5\u5f25\u8865\u9057\u6f0f\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u809d\u529f\u80fd\u635f\u4f24\u4f1a\u4f7f\u4f9d\u7ef4\u83ab\u53f8\u66b4\u9732\u91cf\u589e\u52a0\uff0c\u6309\u5982\u4e0b\u65b9\u5f0f\u8fdb\u884c\u7ed9\u836f\u8c03\u6574\uff1a\uff08<span>1<\/span>\uff09\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\uff1a\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u5929<span>7.5mg<\/span>\uff1b\u5982\u679c\u4e0d\u80fd\u5f88\u597d\u5730\u8010\u53d7\uff0c\u53ef\u5c06\u5242\u91cf\u964d\u81f3\u6bcf\u5929<span>5mg<\/span>\u3002\uff08<span>2<\/span>\uff09\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\uff1a\u63a8\u8350\u5242\u91cf\u662f\u6bcf\u5929<span>5mg<\/span>\uff1b\u5982\u679c\u4e0d\u80fd\u5f88\u597d\u5730\u8010\u53d7\uff0c\u53ef\u5c06\u5242\u91cf\u964d\u81f3\u6bcf\u5929<span>2.5mg<\/span>\u3002\uff08<span>3<\/span>\uff09\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\uff1a\u5982\u679c\u9884\u671f\u7684\u83b7\u76ca\u9ad8\u4e8e\u98ce\u9669\uff0c\u53ef\u4ee5\u91c7\u7528\u6bcf\u5929<span>2.5mg<\/span>\uff0c\u4f46\u4e0d\u5f97\u8d85\u8fc7\u8fd9\u4e00\u5242\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u53e3\u8154\u708e\u7b49\uff1b\u5e94\u7279\u522b\u6ce8\u610f\u95f4\u8d28\u6027\u80ba\u708e\u7684\u53d1\u751f\uff0c\u53ef\u80fd\u4f1a\u53d1\u751f\u808c\u9150\u3001\u8840\u7cd6\u548c\u8840\u8102\u5f02\u5e38\uff0c\u6ce8\u610f\u7528\u836f\u671f\u95f4\u590d\u67e5\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u907f\u514d\u5408\u5e76\u4f7f\u7528\u5f3a\u6548<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\uff0c\u786e\u9700\u5408\u7528\u7684\uff0c\u9700\u589e\u52a0\u5242\u91cf\uff0c\u6700\u5927\u5242\u91cf\u6bcf\u5929<span>20mg<\/span>\u3002\u5982\u9700\u4f7f\u7528<span>CYP3A4<\/span>\u4e2d\u5ea6\u6291\u5236\u5242\u6216<span>P-<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\uff0c\u51cf\u91cf\u81f3\u6bcf\u5929<span>2.5mg<\/span>\uff0c\u5982\u679c\u8010\u53d7\u53ef\u589e\u52a0\u81f3\u5242\u91cf\u6bcf\u5929<span>5mg<\/span>\u3002\u907f\u514d\u5408\u7528\u53ef\u6291\u5236<span>CYP<\/span>\u548c<span>P-<\/span>\u7cd6\u86cb\u767d\u6d3b\u6027\u7684\u98df\u7269\u6216\u8425\u517b\u8865\u5145\u5242\uff0c\u5982\u8461\u8404\u67da\u6c41\u7b49\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u5e94\u907f\u514d\u63a5\u79cd\u6d3b\u75ab\u82d7\uff0c\u907f\u514d\u4e0e\u63a5\u79cd\u8fc7\u6d3b\u75ab\u82d7\u7684\u4eba\u5bc6\u5207\u63a5\u89e6\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u598a\u5a20\u5987\u5973\u670d\u7528\u65f6\u53ef\u80fd\u5bf9\u80ce\u513f\u4ea7\u751f\u5371\u5bb3\uff0c\u5e94\u5145\u5206\u544a\u77e5\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u3001<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5730\u8212\u5355\u6297<span> Denosumab<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>120mg<\/span>\uff08<span>1.7ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u4e0d\u53ef\u624b\u672f\u5207\u9664\u6216\u8005\u624b\u672f\u5207\u9664\u53ef\u80fd\u5bfc\u81f4\u4e25\u91cd\u529f\u80fd\u969c\u788d\u7684\u9aa8\u5de8\u7ec6\u80de\u7624\uff0c\u5305\u62ec\u6210\u4eba\u548c\u9aa8\u9abc\u53d1\u80b2\u6210\u719f\uff08\u5b9a\u4e49\u4e3a\u81f3\u5c11\u4e00\u5904\u6210\u719f\u957f\u9aa8\u4e14\u4f53\u91cd\u2265<span>45kg<\/span>\uff09\u7684\u9752\u5c11\u5e74\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5730\u8212\u5355\u6297\u6cbb\u7597<span>120mg<\/span>\u6bcf<span>4<\/span>\u5468\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\uff08\u4e0a\u81c2\u3001\u5927\u817f\u6216\u8179\u90e8\uff09\uff0c\u7981\u6b62\u9759\u8109\u3001\u808c\u8089\u548c\u76ae\u5185\u6ce8\u5c04\uff0c\u6cbb\u7597\u7b2c<span>1<\/span>\u4e2a\u6708\u7684\u7b2c<span>8<\/span>\u548c\u7b2c<span>15<\/span>\u5929\u9700\u5730\u8212\u5355\u6297<span>120mg<\/span>\u76ae\u4e0b\u8865\u5145\u6ce8\u5c04\u5404\u4e00\u6b21\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5730\u8212\u5355\u6297\u6cbb\u7597\u524d\u5fc5\u987b\u5148\u68c0\u6d4b\u8840\u9499\u6c34\u5e73\uff0c\u5982\u6709\u4f4e\u9499\u8840\u75c7\u9700\u8981\u5148\u7ea0\u6b63\u3002\u5bf9\u4e8e\u6709\u6613\u53d1\u751f\u4f4e\u9499\u8840\u75c7\u548c\u77ff\u7269\u8d28\u4ee3\u8c22\u5931\u8861\u503e\u5411\u60a3\u8005\uff08\u5982\u6709\u7532\u72b6\u65c1\u817a\u529f\u80fd\u51cf\u9000\u75c7\u53f2\u3001\u7532\u72b6\u817a\u548c\u7532\u72b6\u65c1\u817a\u624b\u672f\u53f2\u3001\u8425\u517b\u4e0d\u826f\u3001\u5c0f\u80a0\u5207\u9664\u3001\u4e25\u91cd\u80be\u529f\u80fd\u635f\u4f24\u5982\u808c\u9150\u6e05\u9664\u7387\u2264<span>30ml\/min<\/span>\u548c<span>\/<\/span>\u6216\u63a5\u53d7\u900f\u6790\u548c\u9499\u8865\u5145\u4e0d\u8db3<span>\/<\/span>\u65e0\u9499\u8865\u5145\uff09\uff0c\u4e34\u5e8a\u9700\u5bc6\u5207\u76d1\u6d4b\u5176\u8840\u808c\u9150\u53ca\u8840\u7535\u89e3\u8d28\u6c34\u5e73\uff08\u5982\u78f7\u548c\u9541\uff09\uff0c\u5e76\u6307\u5bfc\u6b64\u7c7b\u60a3\u8005\u5173\u6ce8\u4f4e\u9499\u8840\u75c7\u7684\u75c7\u72b6\uff0c\u6bcf\u5929\u670d\u7528\u9499<span>500mg<\/span>\u548c\u7ef4\u751f\u7d20<span>D 400IU<\/span>\u4ee5\u6cbb\u7597\u6216\u9884\u9632\u4f4e\u9499\u8840\u75c7\u3002\u5730\u8212\u5355\u6297\u4e0d\u5b9c\u4e0e\u53cc\u81a6\u9178\u76d0\u5408\u5e76\u7528\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u670d\u7528\u514d\u75ab\u6291\u5236\u5242\u6216\u514d\u75ab\u7cfb\u7edf\u53d7\u635f\u7684\u60a3\u8005\u63a5\u53d7\u5730\u8212\u5355\u6297\u6cbb\u7597\u53d1\u751f\u4e25\u91cd\u611f\u67d3\u7684\u98ce\u9669\u53ef\u80fd\u4f1a\u589e\u52a0\uff0c\u7528\u836f\u524d\u9700\u5145\u5206\u8003\u8651\u6548\u76ca<span>&#8211;<\/span>\u98ce\u9669\u6bd4\u3002\u5bf9\u4e8e\u4f7f\u7528\u5730\u8212\u5355\u6297\u53d1\u751f\u4e25\u91cd\u611f\u67d3\u8005\uff0c\u533b\u5e08\u5e94\u8bc4\u4f30\u7ee7\u7eed\u7528\u836f\u7684\u98ce\u9669\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0b\u988c\u9aa8\u574f\u6b7b\uff08\u53ef\u81ea\u53d1\u6027\u53d1\u751f\uff09\u901a\u5e38\u4f34\u968f\u7740\u62d4\u7259\u548c\u5ef6\u8fdf\u6108\u5408\u7684\u5c40\u90e8\u611f\u67d3\u53d1\u751f\u3002\u5730\u8212\u5355\u6297\u5f00\u59cb\u6cbb\u7597\u524d\u5e94\u8fdb\u884c\u5e38\u89c4\u7684\u53e3\u8154\u68c0\u67e5\uff0c\u6cbb\u7597\u5f00\u59cb\u540e\u9700\u4fdd\u6301\u826f\u597d\u7684\u53e3\u8154\u536b\u751f\u3002\u6cbb\u7597\u671f\u95f4\u907f\u514d\u4fb5\u5165\u6027\u9f7f\u79d1\u624b\u672f\u548c\u64cd\u4f5c\uff08\u5982\u62d4\u7259\u3001\u7259\u79d1\u690d\u5165\u3001\u9aa8\u624b\u672f\u7b49\uff09\u3002\u5982\u53d1\u751f\u4e0b\u988c\u9aa8\u574f\u6b7b\uff0c\u9488\u5bf9\u4e0b\u988c\u9aa8\u574f\u6b7b\u7684\u6cbb\u7597\u53ef\u80fd\u53cd\u5012\u52a0\u91cd\u75c5\u60c5\uff0c\u6b64\u65f6\u5e94\u8003\u8651\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u80b2\u9f84\u671f\u5987\u5973\u5728\u63a5\u53d7\u6cbb\u7597\u671f\u95f4\u4ee5\u53ca\u5728\u6700\u540e\u4e00\u5242\u6cbb\u7597\u540e\u81f3\u5c11<span>5<\/span>\u4e2a\u6708\u5185\u91c7\u53d6\u6709\u6548\u7684\u907f\u5b55\u63aa\u65bd\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u5173\u8282\u75db\u3001\u5934\u75db\u3001\u6076\u5fc3\u3001\u80cc\u90e8\u75bc\u75db\u3001\u75b2\u52b3\u548c\u56db\u80a2\u75bc\u75db\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7f8e\u56fd<span>FDA<\/span>\u6279\u51c6\u7684\u5176\u4ed6\u9002\u5e94\u8bc1\u8fd8\u5305\u62ec\uff1a\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u548c\u5b9e\u4f53\u7624\u9aa8\u8f6c\u79fb\u60a3\u8005\u4e2d\u9aa8\u76f8\u5173\u4e8b\u4ef6\u9884\u9632\uff1b\u53cc\u81a6\u9178\u76d0\u96be\u6cbb\u6027\u6076\u6027\u80bf\u7624\u5bfc\u81f4\u7684\u9ad8\u9499\u8840\u75c7\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5730\u8212\u5355\u6297\u7528\u4e8e\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u548c\u5b9e\u4f53\u7624\u9aa8\u8f6c\u79fb\u60a3\u8005\u4e2d\u9aa8\u76f8\u5173\u4e8b\u4ef6\u9884\u9632\u7684\u65b0\u9002\u5e94\u8bc1\u4e0a\u5e02\u7533\u8bf7\u5df2\u4e8e<span>2020<\/span>\u5e74<span>4<\/span>\u6708\u88ab\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6b63\u5f0f\u53d7\u7406\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e09\u3001<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c<span> Anlotinib<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>8mg<\/span>\u3001<span>10mg<\/span>\u3001<span>12mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u7528\u4e8e\u817a\u6ce1\u72b6\u8f6f\u7ec4\u7ec7\u8089\u7624\u3001\u900f\u660e\u7ec6\u80de\u8089\u7624\u4ee5\u53ca\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u542b\u84bd\u73af\u7c7b\u5316\u7597\u65b9\u6848\u6cbb\u7597\u540e\u8fdb\u5c55\u6216\u590d\u53d1\u7684\u5176\u4ed6\u665a\u671f\u8f6f\u7ec4\u7ec7\u8089\u7624\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>12mg<\/span>\u6bcf\u5929\u4e00\u6b21\u65e9\u9910\u524d\u53e3\u670d\u3002\u8fde\u7eed\u670d\u836f<span>2<\/span>\u5468\uff0c\u505c\u836f<span>1<\/span>\u5468\uff0c\u5373<span>3<\/span>\u5468\uff08<span>21<\/span>\u5929\uff09\u4e3a\u4e00\u4e2a\u6cbb\u7597\u5468\u671f\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u4e0d\u826f\u53cd\u5e94\u3002\u7528\u836f\u671f\u95f4\u5982\u51fa\u73b0\u6f0f\u670d\uff0c\u786e\u8ba4\u8ddd\u4e0b\u6b21\u7528\u836f\u65f6\u95f4\u77ed\u4e8e<span>12<\/span>\u5c0f\u65f6\uff0c\u5219\u4e0d\u518d\u8865\u670d\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c\u6240\u81f4\u7684\u4e0d\u826f\u53cd\u5e94\u53ef\u901a\u8fc7\u5bf9\u75c7\u6cbb\u7597\u3001\u6682\u505c\u7528\u836f\u548c<span>\/<\/span>\u6216\u8c03\u6574\u5242\u91cf\u7b49\u65b9\u5f0f\u5904\u7406\u3002\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7a0b\u5ea6\uff0c\u5efa\u8bae\u6309\u4ee5\u4e0b\u65b9\u6cd5\u8c03\u6574\u5242\u91cf\uff1a\uff08<span>1<\/span>\uff09\u7b2c\u4e00\u6b21\u8c03\u6574\u5242\u91cf\uff1a<span>10mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u8fde\u670d<span>2<\/span>\u5468\uff0c\u505c\u836f<span>1<\/span>\u5468\u3002\uff08<span>2<\/span>\uff09\u7b2c\u4e8c\u6b21\u8c03\u6574\u5242\u91cf\uff1a<span>8mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u8fde\u670d<span>2<\/span>\u5468\uff0c\u505c\u836f<span>1<\/span>\u5468\u3002\u5982<span>8mg<\/span>\u5242\u91cf\u4ecd\u65e0\u6cd5\u8010\u53d7\uff0c\u5219\u6c38\u4e45\u505c\u836f\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53d1\u751f\u975e\u51fa\u8840\u6027\u4e0d\u826f\u53cd\u5e94\u65f6\uff0c\u53c2\u7167\u8868<span>8<\/span>\u7684\u603b\u539f\u5219\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8868<span>8<\/span>&emsp;\u5b89\u7f57\u66ff\u5c3c\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7ea7\u522b\u7684\u5242\u91cf\u8c03\u6574\u603b\u539f\u5219<span><\/span><\/span><\/b>\n<\/p>\n<table class=\"MsoTableGrid\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"1148\" style=\"width:430.65pt;border-collapse:collapse;border:none;\">\n<tbody>\n<tr>\n<td width=\"379\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u826f\u53cd\u5e94\u7ea7\u522b<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08<span>NCI CTCAE 5.0<\/span>\uff09<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"379\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ed9\u836f\u65f6\u95f4<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"391\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u8c03\u6574\u539f\u5219<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"379\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"379\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7528\u836f\uff0c\u5f85\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u5230\uff1c<span>2<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"391\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u540e\u7ee7\u7eed\u7ed9\u836f\uff1b\u5982<span>2<\/span>\u5468\u540e\u4ecd\u672a\u6062\u590d\uff0c\u5219\u8003\u8651\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"379\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"379\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7528\u836f\uff0c\u5f85\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u5230\uff1c<span>2<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"391\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u540e\u7ee7\u7eed\u7ed9\u836f\uff1b\u5982<span>2<\/span>\u5468\u540e\u4ecd\u672a\u6062\u590d\uff0c\u5219\u8003\u8651\u6c38\u4e45\u505c\u836f\uff1b\u6216\u6839\u636e\u533b\u5e08\u5224\u65ad\u8003\u8651\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">NCI CTCAE 5.0<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff1a\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\u5e38\u89c1\u836f\u7269\u6bd2\u6027\u53cd\u5e94\u5206\u7ea7\u6807\u51c6<span>5.0<\/span>\u7248\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51fa\u8840\u662f\u5b89\u7f57\u66ff\u5c3c\u6700\u91cd\u8981\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5177\u6709\u51fa\u8840\u98ce\u9669\u3001\u51dd\u8840\u529f\u80fd\u5f02\u5e38\u60a3\u8005\u5e94\u614e\u7528\u5b89\u7f57\u66ff\u5c3c\uff0c\u670d\u836f\u671f\u95f4\u5e94\u4e25\u5bc6\u76d1\u6d4b\u51dd\u8840\u9176\u539f\u65f6\u95f4\u548c<span>INR<\/span>\u3002\u4e00\u65e6\u51fa\u73b0<span>2<\/span>\u7ea7\u51fa\u8840\u4e8b\u4ef6\u5e94\u6682\u505c\u7528\u836f\uff0c\u5982<span>2<\/span>\u5468\u5185\u80fd\u6062\u590d\u81f3\uff1c<span>2<\/span>\u7ea7\u8005\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u7ee7\u7eed\u7528\u836f\uff1b\u5982\u518d\u6b21\u51fa\u73b0\uff0c\u5e94\u8003\u8651\u6c38\u4e45\u505c\u836f\u3002\u4e00\u65e6\u51fa\u73b0<span>3<\/span>\u7ea7\u6216\u4ee5\u4e0a\u7684\u51fa\u8840\u4e8b\u4ef6\uff0c\u6c38\u4e45\u505c\u836f\u3002\u5f53\u53d1\u751f\u51fa\u8840\u7684\u4e0d\u826f\u53cd\u5e94\u65f6\u53c2\u7167\u8868<span>9<\/span>\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8868<span>9<\/span>&emsp;\u5b89\u7f57\u66ff\u5c3c\u53d1\u751f<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51fa\u8840\u4e0d\u826f\u53cd\u5e94\u65f6\u7684\u5242\u91cf\u8c03\u6574\u539f\u5219<span><\/span><\/span><\/b>\n<\/p>\n<table class=\"MsoTableGrid\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\" style=\"border-collapse:collapse;border:none;\">\n<tbody>\n<tr>\n<td width=\"336\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51fa\u8840\u4e8b\u4ef6<sup><span>*<\/span><\/sup><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"801\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u8c03\u6574\u539f\u5219<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"336\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"801\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7528\u836f\uff0c\u5e76\u91c7\u53d6\u79ef\u6781\u5bf9\u75c7\u6cbb\u7597\u5904\u7406\uff1b<span>2<\/span>\u5468\u5185\u80fd\u6062\u590d\u81f3\uff1c<span>2<\/span>\u7ea7\u65f6\uff0c\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u7ee7\u7eed\u7528\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"336\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2265<span>3<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"801\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f\uff0c\u5e76\u91c7\u53d6\u7d27\u6025\u533b\u5b66\u5e72\u9884\u5904\u7406<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\" style=\"text-indent:28.3pt;\">\n\t<sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">*<\/span><\/sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51fa\u8840\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\uff1a\u54af\u8840\u3001\u6d88\u5316\u9053\u51fa\u8840\u3001\u9f3b\u51fa\u8840\u3001\u652f\u6c14\u7ba1\u51fa\u8840\u3001\u7259\u9f88\u51fa\u8840\u3001\u8089\u773c\u8840\u5c3f\u3001\u4fbf\u6f5c\u8840\u548c\u8111\u51fa\u8840\u7b49\u3002<b><span><\/span><\/b><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u524d<span>4<\/span>\u5468\u5185\u51fa\u73b0\u2265<span>CTCAE3<\/span>\u7ea7\u7684\u4efb\u4f55\u51fa\u8840\u4e8b\u4ef6\u3001\u5b58\u5728\u672a\u6108\u5408\u521b\u53e3\u3001\u6e83\u75a1\u6216\u9aa8\u6298\u548c<span>6<\/span>\u4e2a\u6708\u5185\u53d1\u751f\u8fc7\u52a8<span>\/<\/span>\u9759\u8109\u8840\u6813\u4e8b\u4ef6\u5982\u8111\u8840\u7ba1\u610f\u5916\uff08\u5305\u62ec\u6682\u65f6\u6027\u7f3a\u8840\u6027\u53d1\u4f5c\uff09\u3001\u6df1\u9759\u8109\u8840\u6813\u53ca\u80ba\u6813\u585e\u7684\u60a3\u8005\uff0c\u5e94\u5728\u533b\u5e08\u6307\u5bfc\u4e0b\u7528\u836f\uff0c\u5bf9\u5408\u7528\u534e\u6cd5\u6797\u7684\u60a3\u8005\u5e94\u6bcf<span>1<\/span>\uff5e<span>2<\/span>\u5468\u76d1\u6d4b\u51dd\u8840\u9176\u539f\u65f6\u95f4\u548c<span>INR<\/span>\u503c\uff0c\u5e76\u6ce8\u610f\u4e34\u5e8a\u51fa\u8840\u8ff9\u8c61\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9ad8\u8840\u538b\u662f\u5b89\u7f57\u66ff\u5c3c\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u7528\u836f\u671f\u95f4\u5e94\u5bc6\u5207\u76d1\u6d4b\u8840\u538b\uff0c\u9ad8\u8840\u538b\u591a\u5728\u5f00\u59cb\u670d\u836f\u540e<span>2<\/span>\u5468\u5185\u51fa\u73b0\uff0c\u5229\u5c3f\u5242\u3001\u03b2\u53d7\u4f53\u963b\u6ede\u5242\u548c\u9499\u901a\u9053\u62ee\u6297\u5242\u7b49\u5e38\u89c4\u964d\u8840\u538b\u836f\u7269\u4e00\u822c\u53ef\u4ee5\u63a7\u5236\u3002\u5f00\u59cb\u7528\u836f\u7684\u524d<span>6<\/span>\u5468\u5e94\u6bcf\u5929\u76d1\u6d4b\u8840\u538b\uff0c\u540e\u7eed\u7528\u836f\u671f\u95f4\u6bcf\u5468\u76d1\u6d4b\u8840\u538b<span>2<\/span>\uff5e<span>3<\/span>\u6b21\uff0c\u53d1\u73b0\u8840\u538b\u5347\u9ad8\u6216\u5934\u75db\u5934\u6655\u75c7\u72b6\u5e94\u79ef\u6781\u4e0e\u533b\u5e08\u6c9f\u901a\u5e76\u5728\u533b\u5e08\u6307\u5bfc\u4e0b\u63a5\u53d7\u964d\u538b\u836f\u7269\u6cbb\u7597\uff0c\u6682\u505c\u5b89\u7f57\u66ff\u5c3c\u6cbb\u7597\u6216\u5242\u91cf\u8c03\u6574\u3002\u5f53\u53d1\u751f<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u9ad8\u8840\u538b\uff08\u6536\u7f29\u538b\u2265<span>180mmHg<\/span>\u6216\u8212\u5f20\u538b\u2265<span>110mmHg<\/span>\uff09\uff0c\u5e94\u6682\u505c\u7528\u836f\uff1b\u5982\u6062\u590d\u7528\u836f\u540e\u518d\u6b21\u51fa\u73b0<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u9ad8\u8840\u538b\uff0c\u5e94\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u540e\u7ee7\u7eed\u7528\u836f\u3002\u5982<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u9ad8\u8840\u538b\u6301\u7eed\uff0c\u5efa\u8bae\u505c\u836f\u3002\u51fa\u73b0\u9ad8\u8840\u538b\u5371\u8c61\u7684\u60a3\u8005\uff0c\u5e94\u7acb\u5373\u505c\u836f\u5e76\u63a5\u53d7\u5fc3\u8840\u7ba1\u4e13\u79d1\u51b6\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c\u53ef\u5ef6\u957f<span>QTc<\/span>\u95f4\u671f\uff0c<span>QTc<\/span>\u95f4\u671f\u5ef6\u957f\u53ef\u5bfc\u81f4\u5ba4\u6027\u5feb\u901f\u6027\u5fc3\u5f8b\u5931\u5e38\uff08\u5982\u5c16\u7aef\u626d\u8f6c\u578b\u5ba4\u6027\u5fc3\u52a8\u8fc7\u901f\uff09\uff0c\u6b7b\u4ea1\u98ce\u9669\u589e\u52a0\u3002\u60a3\u6709\u5148\u5929\u6027\u957f<span>QTc<\/span>\u95f4\u671f\u7efc\u5408\u5f81\u7684\u60a3\u8005\u5e94\u907f\u514d\u7528\u836f\uff0c\u60a3\u6709\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\u3001\u8840\u7535\u89e3\u8d28\u5f02\u5e38\u6216\u4f7f\u7528\u5df2\u77e5\u80fd\u591f\u5ef6\u957f<span>QTc<\/span>\u95f4\u671f\u836f\u7269\u7684\u60a3\u8005\u5e94\u5b9a\u671f\uff08\u6bcf<span>3<\/span>\uff5e<span>6<\/span>\u5468\uff09\u63a5\u53d7\u5fc3\u7535\u56fe\u548c\u8840\u7535\u89e3\u8d28\u7684\u68c0\u6d4b\u3002\u8fde\u7eed\u4e24\u6b21\u72ec\u7acb\u5fc3\u7535\u56fe\u68c0\u6d4b<span>QTc<\/span>\u95f4\u671f\uff1e<span>500ms<\/span>\u7684\u60a3\u8005\u5e94\u6682\u505c\u7528\u836f\uff0c\u76f4\u81f3<span>QTc<\/span>\u95f4\u671f\u2264<span>480ms<\/span>\u6216\u964d\u81f3\u57fa\u7ebf\u6c34\u5e73\uff08\u5f53\u57fa\u7ebf<span>QTc<\/span>\u95f4\u671f\uff1e<span>480ms<\/span>\uff09\uff0c\u5e94\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u7528\u836f\u3002\u5bf9\u4e8e\u51fa\u73b0\u4efb\u4f55\u7ea7\u522b\u7684<span>QTc<\/span>\u95f4\u671f\u5ef6\u957f\uff08\u2265<span>450ms<\/span>\uff09\u5e76\u4f34\u6709\u5c16\u7aef\u626d\u8f6c\u578b\u5ba4\u6027\u5fc3\u52a8\u8fc7\u901f\u3001\u591a\u5f62\u6027\u5ba4\u6027\u5fc3\u52a8\u8fc7\u901f\u3001\u4e25\u91cd\u5fc3\u5f8b\u5931\u5e38\u7684\u60a3\u8005\u5e94\u6c38\u4e45\u505c\u836f\uff0c\u5e76\u53ca\u65f6\u53bb\u5fc3\u8840\u7ba1\u4e13\u79d1\u5c31\u8bca\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u7840\u5fc3\u529f\u80fd\u5f02\u5e38\u7684\u60a3\u8005\uff0c\u5e94\u6bcf<span>6<\/span>\u5468\u505a\u5fc3\u810f\u529f\u80fd\u68c0\u67e5\uff0c\u5982\u51fa\u73b0\u2162\uff5e\u2163\u7ea7\u5fc3\u529f\u80fd\u4e0d\u5168\u6216\u5fc3\u810f\u5f69\u8d85\u663e\u793a\u5de6\u5ba4\u5c04\u8840\u5206\u6570\uff1c<span>50%<\/span>\u7684\u60a3\u8005\u5e94\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80bf\u7624\u60a3\u8005\u80ba\u53ca\u80f8\u819c\u4e0b\u75c5\u7076\u9000\u7f29\u5b58\u5728\u81ea\u53d1\u6027\u6c14\u80f8\u98ce\u9669\uff0c\u5b89\u7f57\u66ff\u5c3c\u6cbb\u7597\u671f\u95f4\u6216\u6cbb\u7597\u540e\u7a81\u53d1\u80f8\u75db\u6216\u547c\u5438\u56f0\u96be\u7b49\u75c7\u72b6\u5e94\u7acb\u5373\u5c31\u533b\uff0c\u786e\u8ba4\u6c14\u80f8\u540e\u5e94\u884c\u80f8\u8154\u95ed\u5f0f\u5f15\u6d41\u672f\u6216\u5176\u4ed6\u533b\u5b66\u5e72\u9884\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c\u53ef\u5f15\u8d77\u8f6c\u6c28\u9176\u6216\u603b\u80c6\u7ea2\u7d20\u5347\u9ad8\u3002\u8f7b\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u614e\u7528\uff0c\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7981\u7528\u3002\u670d\u7528\u5b89\u7f57\u66ff\u5c3c\u671f\u95f4\u5e94\u76d1\u6d4b\u8f6c\u6c28\u9176\u548c\u80c6\u7ea2\u7d20\uff0c\u5efa\u8bae\u5728\u6cbb\u7597\u5f00\u59cb\u524d\u3001\u6bcf\u4e2a\u6cbb\u7597\u5468\u671f\u4ee5\u53ca\u4e34\u5e8a\u9700\u8981\u65f6\u68c0\u6d4b\u809d\u529f\u80fd\uff08<span>ALT<\/span>\u3001<span>AST<\/span>\u3001\u80c6\u7ea2\u7d20\uff09\u3002\u5f53\u60a3\u8005\u53d1\u751f<span>2<\/span>\u7ea7\u809d\u529f\u80fd\u5f02\u5e38\u65f6\uff0c\u5e94\u589e\u52a0\u68c0\u6d4b\u9891\u7387\uff0c\u5f53\u60a3\u8005\u53d1\u751f<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u8f6c\u6c28\u9176\u6216\u603b\u80c6\u7ea2\u7d20\u5347\u9ad8\u65f6\uff0c\u5e94\u6682\u505c\u7528\u836f\uff0c\u540c\u65f6\u6bcf\u5468\u68c0\u6d4b\u8f6c\u6c28\u9176\u53ca\u603b\u80c6\u7ea2\u7d20<span>2<\/span>\uff5e<span>3<\/span>\u6b21\uff0c<span>2<\/span>\u5468\u5185\u6062\u590d\u81f3\uff1c<span>2<\/span>\u7ea7\u540e\u53ef\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u7ee7\u7eed\u7528\u836f\uff1b\u5982\u4e0b\u8c03\u5242\u91cf\u540e\u4ecd\u51fa\u73b0<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u8f6c\u6c28\u9176\u6216\u80c6\u7ea2\u7d20\u6301\u7eed\u5347\u9ad8\uff0c\u5efa\u8bae\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u7840\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u614e\u7528\u5b89\u7f57\u66ff\u5c3c\uff0c\u5efa\u8bae\u6bcf<span>6<\/span>\u5468\u68c0\u67e5\u5c3f\u5e38\u89c4\uff0c\u5bf9\u8fde\u7eed\u4e24\u6b21\u5c3f\u86cb\u767d\uff08<span>++<\/span>\uff09\u4ee5\u4e0a\u8005\u8fdb\u884c<span>24<\/span>\u5c0f\u65f6\u5c3f\u86cb\u767d\u5b9a\u91cf\u68c0\u6d4b\uff0c\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7ea7\u522b\u91c7\u53d6\u6682\u505c\u7528\u836f\u3001\u5242\u91cf\u8c03\u6574\u548c\u6c38\u4e45\u505c\u836f\u7b49\u5904\u7406\u63aa\u65bd\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u5b89\u7f57\u66ff\u5c3c\u6cbb\u7597\u5f00\u59cb\u524d\uff0c\u5efa\u8bae\u68c0\u6d4b\u57fa\u7ebf\u7532\u72b6\u817a\u529f\u80fd\uff0c\u5728\u6cbb\u7597\u671f\u95f4\uff0c\u5bf9\u6240\u6709\u60a3\u8005\u5e94\u5bc6\u5207\u89c2\u5bdf\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u7684\u4f53\u5f81\u548c\u75c7\u72b6\uff0c\u5b9a\u671f\u8fdb\u884c\u7532\u72b6\u817a\u529f\u80fd\u7684\u5b9e\u9a8c\u5ba4\u76d1\u6d4b\uff0c\u5bf9\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u7684\u60a3\u8005\u8fdb\u884c\u89c4\u8303\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c\u53ef\u5bfc\u81f4\u8179\u6cfb\uff0c\u6ce8\u610f\u8bc4\u4f30\u662f\u5426\u6709\u8131\u6c34\u6216\u7535\u89e3\u8d28\u5931\u8861\uff0c\u5fc5\u8981\u65f6\u8003\u8651\u9759\u8109\u8865\u6db2\uff0c\u4f7f\u7528\u6d1b\u54cc\u4e01\u80fa\u3001\u76ca\u751f\u83cc\u548c\u8499\u8131\u77f3\u6563\u6cbb\u7597\u3002\u4e25\u91cd\u65f6\u4e5f\u53ef\u8003\u8651\u9884\u9632\u6027\u6297\u751f\u7d20\u6cbb\u7597\u5e76\u52a0\u7528\u751f\u957f\u6291\u7d20\u3002\u5bf9\u53d1\u751f\u4e25\u91cd\u6216\u6301\u7eed\u6027\u8179\u6cfb\u751a\u81f3\u8131\u6c34\u7684\u60a3\u8005\uff0c\u9700\u8981\u9274\u522b\u5176\u4ed6\u8179\u6cfb\u539f\u56e0\uff08\u80a0\u9053\u83cc\u7fa4\u7d0a\u4e71\u3001\u514d\u75ab\u529f\u80fd\u4f4e\u4e0b\u3001\u7c7b\u764c\u7efc\u5408\u5f81\u7b49\uff09\uff0c\u53ef\u91c7\u53d6\u6682\u505c\u7528\u836f\u3001\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u76f4\u81f3\u6c38\u4e45\u505c\u836f\u63aa\u65bd\uff0c\u5e76\u6839\u636e\u8179\u6cfb\u539f\u56e0\u79ef\u6781\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">12.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c\u6cbb\u7597\u53ef\u4ee5\u51fa\u73b0\u53e3\u8154\u75bc\u75db\u3001\u53e3\u8154\u9ecf\u819c\u708e\u548c\u7259\u75bc\u3002\u7259\u9f88\u3001\u53e3\u8154\u80bf\u75db\u60a3\u8005\u5e94\u4fdd\u6301\u53e3\u8154\u6e05\u6d01\u3001\u6b62\u75db\uff0c\u9632\u6cbb\u591a\u91cd\u611f\u67d3\uff0c\u9632\u6b62\u53e3\u8154\u9ecf\u819c\u708e\u8fdb\u4e00\u6b65\u52a0\u91cd\u3002\u63a8\u8350\u4f7f\u7528\u542b\u5229\u591a\u5361\u56e0\u3001\u78b3\u9178\u6c22\u94a0\u6216\u6c2f\u5df1\u5b9a\u7b49\u6210\u5206\u7684\u542b\u6f31\u5242\u6216\u6d82\u5242\u5bf9\u75c7\u5904\u7406\uff0c\u4fc3\u8fdb\u53e3\u8154\u9ecf\u819c\u6108\u5408\u3002\u6ce8\u610f\u5747\u8861\u8425\u517b\u548c\u6c34\u7684\u6444\u53d6\uff0c\u81b3\u98df\u4e2a\u4f53\u5316\uff0c\u907f\u514d\u70ed\u3001\u8f9b\u8fa3\u98df\u7269\uff0c\u5fcc\u70df\u9152\uff0c\u7981\u7528\u542b\u9152\u7cbe\u7684\u542b\u6f31\u5242\uff0c\u5fc5\u8981\u65f6\u53ef\u5230\u53e3\u8154\u4e13\u79d1\u5c31\u8bca\u3002\u53d1\u751f\u7259\u9f88\u3001\u53e3\u8154\u80bf\u75db\u65f6\uff0c\u53ef\u91c7\u53d6\u6682\u505c\u7528\u836f\u3001\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u76f4\u81f3\u6c38\u4e45\u505c\u836f\u63aa\u65bd\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">13.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u624b\u8db3\u7efc\u5408\u5f81\u591a\u5728\u5b89\u7f57\u66ff\u5c3c\u7ed9\u836f<span>2<\/span>\u5468\u5185\u51fa\u73b0\uff0c\u8868\u73b0\u4e3a\u624b\u8db3\u638c\u5e95\u90e8\u4f4d\u76ae\u80a4\u80bf\u80c0\u3001\u5265\u843d\u3001\u6c34\u6ce1\u3001\u76b2\u88c2\u3001\u51fa\u8840\u6216\u7ea2\u6591\u7684\u590d\u5408\u8868\u73b0\uff0c\u5e38\u4f34\u6709\u75bc\u75db\u3002<span>2<\/span>\u7ea7\u624b\u8db3\u7efc\u5408\u5f81\u60a3\u8005\u5e94\u91c7\u53d6\u5bf9\u75c7\u6cbb\u7597\u5904\u7406\uff0c\u5305\u62ec\u52a0\u5f3a\u76ae\u80a4\u62a4\u7406\uff0c\u4fdd\u6301\u76ae\u80a4\u6e05\u6d01\uff0c\u907f\u514d\u7ee7\u53d1\u611f\u67d3\uff0c\u907f\u514d\u538b\u529b\u548c\u6469\u64e6\uff1b\u5c40\u90e8\u4f7f\u7528\u542b\u5c3f\u7d20\u548c\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6210\u5206\u7684\u4e73\u6db2\u6216\u6da6\u6ed1\u5242\uff1b\u53d1\u751f\u611f\u67d3\u65f6\u5c40\u90e8\u4f7f\u7528\u6297\u771f\u83cc\u836f\u6216\u6297\u751f\u7d20\u6cbb\u7597\uff0c\u5efa\u8bae\u5728\u76ae\u80a4\u4e13\u79d1\u533b\u5e08\u6307\u5bfc\u4e0b\u4f7f\u7528\u3002\u5982\u51fa\u73b0\u2265<span>3<\/span>\u7ea7\u7684\u624b\u8db3\u7efc\u5408\u5f81\uff0c\u5e94\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u540e\u7ee7\u7eed\u7528\u836f\u3002\u5982\u4e0d\u826f\u53cd\u5e94\u4ecd\u6301\u7eed\uff0c\u5e94\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">14.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51fa\u73b0\u9ad8\u8102\u8840\u75c7\u7684\u60a3\u8005\u5efa\u8bae\u8c03\u6574\u4e3a\u4f4e\u8102\u996e\u98df\u3002\u2265<span>2<\/span>\u7ea7\u7684\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\uff08\u2265<span>7.75mmol\/L<\/span>\uff09\u6216\u2265<span>2<\/span>\u7ea7\u7684\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\uff08\u2265<span>2.5<\/span>\u500d<span>ULN<\/span>\uff09\uff0c\u5e94\u4f7f\u7528\u7f9f\u7532\u57fa\u620a\u4e8c\u9170\u8f85\u9176<span>A<\/span>\u8fd8\u539f\u9176\u6291\u5236\u5242\u7b49\u964d\u8840\u8102\u836f\u7269\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">15.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c1a\u4e0d\u786e\u5b9a\u5b89\u7f57\u66ff\u5c3c\u662f\u5426\u53ef\u5bfc\u81f4\u766b\u75eb\u6216\u589e\u52a0\u766b\u75eb\u98ce\u9669\uff0c\u65e2\u5f80\u6709\u766b\u75eb\u75c5\u53f2\u7684\u60a3\u8005\u5e94\u614e\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">16.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53ef\u9006\u6027\u540e\u90e8\u767d\u8d28\u8111\u75c5\u7efc\u5408\u5f81\u5728<span>VEGFR<\/span>\u6291\u5236\u5242\u7c7b\u836f\u7269\u6cbb\u7597\u80bf\u7624\u4e2d\u6709\u62a5\u9053\uff0c\u5e76\u4e14\u53ef\u80fd\u81f4\u547d\u3002\u5728\u5b89\u7f57\u66ff\u5c3c\u7814\u7a76\u4e2d\u5c1a\u672a\u62a5\u544a\u6b64\u7c7b\u4e8b\u4ef6\u53d1\u751f\uff0c\u5728\u5b9e\u9645\u4f7f\u7528\u8fc7\u7a0b\u4e2d\uff0c\u5e94\u5bc6\u5207\u76d1\u6d4b\u76f8\u5173\u7684\u75c7\u72b6\u548c\u4f53\u5f81\uff0c\u4e00\u65e6\u53d1\u751f\u53ef\u9006\u6027\u540e\u90e8\u767d\u8d28\u8111\u75c5\u7efc\u5408\u5f81\u7684\u60a3\u8005\u5e94\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">17.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c\u53ef\u80fd\u5f71\u54cd\u60a3\u8005\u4f24\u53e3\u6108\u5408\uff0c\u5efa\u8bae\u51c6\u5907\u63a5\u53d7\u5916\u79d1\u624b\u672f\u7684\u60a3\u8005\u6682\u505c\u7ed9\u836f\u4ee5\u9884\u9632\u672f\u540e\u4f24\u53e3\u6108\u5408\u5ef6\u8fdf\uff0c\u672f\u540e\u4f55\u65f6\u6062\u590d\u7528\u836f\u7531\u4e34\u5e8a\u533b\u5e08\u6839\u636e\u60a3\u8005\u5177\u4f53\u60c5\u51b5\u5224\u65ad\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">18.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ee\u524d\u7f3a\u4e4f<span>18<\/span>\u5c81\u4ee5\u4e0b\u60a3\u8005\u5e94\u7528\u5b89\u7f57\u66ff\u5c3c\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u8d44\u6599\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2265<span>65<\/span>\u5c81<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8001\u5e74\u60a3\u8005\u4f7f\u7528\u5b89\u7f57\u66ff\u5c3c\u65f6\uff0c\u65e0\u9700\u8c03\u6574\u7528\u836f\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">19.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80b2\u9f84\u671f\u5973\u6027\u5728\u63a5\u53d7\u5b89\u7f57\u66ff\u5c3c\u6cbb\u7597\u671f\u95f4\u548c\u6cbb\u7597\u7ed3\u675f\u81f3\u5c11<span>6<\/span>\u4e2a\u6708\u5185\u5e94\u91c7\u53d6\u6709\u6548\u7684\u907f\u5b55\u63aa\u65bd\uff0c\u598a\u5a20\u671f\u53ca\u54fa\u4e73\u671f\u5987\u5973\u7981\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">20.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u5b89\u7f57\u66ff\u5c3c\u907f\u514d\u4e0e<span>CYP1A2<\/span>\u548c<span>CYP3A4\/5<\/span>\u7684\u5f3a\u6291\u5236\u5242\u53ca\u5f3a\u8bf1\u5bfc\u5242\u5408\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">21.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c\u88ab\u63a8\u8350\u4f5c\u4e3a\u665a\u671f\u6216\u4e0d\u53ef\u5207\u9664\u8f6f\u7ec4\u7ec7\u8089\u7624\u7684\u4e8c\u7ebf\u6cbb\u7597\u836f\u7269\u3001\u665a\u671f\u6216\u4e0d\u53ef\u5207\u9664\u817a\u6ce1\u72b6\u8f6f\u7ec4\u7ec7\u8089\u7624\u7684\u4e00\u7ebf\u6cbb\u7597\u836f\u7269\u3002<span><\/span><\/span>\n<\/p>\n<p><b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><br \/>\n<\/span><\/b> <\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5934\u9888\u90e8\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e00\u3001\u5c3c\u59a5\u73e0\u5355\u6297<span> Nimotuzumab <\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>50mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0e\u653e\u7597\u8054\u5408\u6cbb\u7597<span>EGFR<\/span>\u57fa\u56e0\u9633\u6027\u8868\u8fbe\u7684\u2162\uff5e\u2163\u671f\u9f3b\u54bd\u764c\u3002<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9996\u6b21\u7ed9\u836f\u5e94\u5728\u653e\u5c04\u6cbb\u7597\u7684\u7b2c\u4e00\u5929\uff0c\u5e76\u5728\u653e\u5c04\u6cbb\u7597\u5f00\u59cb\u524d\u5b8c\u6210\u3002\u4e4b\u540e\u6bcf\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u5171<span>8<\/span>\u5468\uff0c\u60a3\u8005\u540c\u65f6\u63a5\u53d7\u6807\u51c6\u7684\u653e\u5c04\u6cbb\u7597\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5fc5\u987b\u6ce8\u610f\u5e38\u89c1\u7684\u76ae\u80a4\u53cd\u5e94\u548c\u8179\u6cfb\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c1a\u672a\u786e\u5b9a<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u4f7f\u7528\u672c\u54c1\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u7531\u719f\u7ec3\u638c\u63e1<span>EGFR<\/span>\u68c0\u6d4b\u6280\u672f\u7684\u4e13\u804c\u4eba\u5458\u8fdb\u884c<span>EGFR<\/span>\u8868\u8fbe\u6c34\u5e73\u7684\u68c0\u9a8c\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c3c\u59a5\u73e0\u5355\u6297\u51bb\u878d\u540e\u6297\u4f53\u5927\u90e8\u5206\u6d3b\u6027\u5c06\u4e27\u5931\uff0c\u6545\u5728\u50a8\u5b58\u8fc7\u7a0b\u4e2d\u4e25\u7981\u51b7\u51bb\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c3c\u59a5\u73e0\u5355\u6297\u914d\u5236\u7684\u6eb6\u6db2\u5728\u8f93\u6db2\u5bb9\u5668\u4e2d<span>2<\/span>\uff5e<span>8<\/span>\u2103\u65f6\uff0c\u5176\u7269\u7406\u548c\u5316\u5b66\u7a33\u5b9a\u6027\u53ef\u4fdd\u6301<span>12<\/span>\u5c0f\u65f6\uff0c\u5728\u5ba4\u6e29\u4e0b\u53ef\u4fdd\u6301<span>8<\/span>\u5c0f\u65f6\u3002\u50a8\u5b58\u65f6\u95f4\u8d85\u8fc7\u4e0a\u8ff0\u65f6\u95f4\uff0c\u4e0d\u5b9c\u7ee7\u7eed\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\" style=\"text-indent:28pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b55\u5987\u6216\u6ca1\u6709\u91c7\u53d6\u6709\u6548\u907f\u5b55\u63aa\u65bd\u7684\u5987\u5973\u5e94\u614e\u7528\u3002\u672c\u54c1\u5c5e\u4e8e<span>IgG1<\/span>\u7c7b\u6297\u4f53\uff0c\u7531\u4e8e\u4eba<span>IgG1<\/span>\u80fd\u591f\u5206\u6ccc\u81f3\u4e73\u6c41\uff0c\u5efa\u8bae\u54fa\u4e73\u671f\u5987\u5973\u5728\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u4ee5\u53ca\u5728\u6700\u540e\u4e00\u6b21\u7ed9\u836f\u540e<span>60<\/span>\u5929\u5185\u505c\u6b62\u54fa\u4e73\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u7279\u745e\u666e\u5229\u5355\u6297 <span>Toripalimab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">80mg<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\uff08<span>2ml<\/span>\uff09<span>\/<\/span>\u74f6\u3001<span>240mg<\/span>\uff08<span>6ml<\/span>\uff09<span>\/<\/span>\u74f6<\/span><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e8c\u7ebf\u53ca\u4ee5\u4e0a\u7cfb\u7edf\u6cbb\u7597\u5931\u8d25\u7684\u590d\u53d1<span>\/<\/span>\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u665a\u671f\u9f3b\u54bd\u764c\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>3mg\/kg<\/span>\uff0c\u9759\u8109\u8f93\u6ce8\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff0c\u76f4\u5230\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u90e8\u5206\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u7684\u60a3\u8005\u53ef\u80fd\u5b58\u5728\u80bf\u7624\u975e\u5178\u578b\u53cd\u5e94\uff0c\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u5728\u5f71\u50cf\u5b66\u4e0a\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u826f\u53cd\u5e94\u4e3a\u8d2b\u8840\u3001<span>ALT<\/span>\u5347\u9ad8\u3001\u4e4f\u529b\u3001<span>AST<\/span>\u5347\u9ad8\u3001\u76ae\u75b9\u3001\u53d1\u70ed\u3001\u8840\u4fc3\u7532\u72b6\u817a\u6fc0\u7d20\u5347\u9ad8\u3001\u767d\u7ec6\u80de\u8ba1\u6570\u51cf\u5c11\u3001\u54b3\u55fd\u3001\u7619\u75d2\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u75c7\u3001\u98df\u6b32\u4e0b\u964d\u3001\u8840\u7cd6\u5347\u9ad8\u548c\u8840\u80c6\u7ea2\u7d20\u5347\u9ad8\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u5927\u591a\u6570\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u662f\u53ef\u9006\u7684\uff0c\u5e76\u4e14\u53ef\u901a\u8fc7\u4e2d\u65ad\u7279\u745e\u666e\u5229\u5355\u6297\u3001\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u548c\uff0f\u6216\u652f\u6301\u6cbb\u7597\u6765\u5904\u7406\u3002\u5bf9\u4e8e\u5927\u90e8\u5206<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u53ca\u67d0\u4e9b\u7279\u5b9a\u7684<span>2<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u9700\u6682\u505c\u7ed9\u836f\u3002\u5bf9\u4e8e<span>4<\/span>\u7ea7\u53ca\u67d0\u4e9b\u7279\u5b9a\u7684<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u9700\u6c38\u4e45\u505c\u836f\u3002\u5bf9\u4e8e<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u53ca\u67d0\u4e9b\u7279\u5b9a\u7684<span>2<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u7ed9\u4e88<span>1<\/span>\uff5e<span>2mg\/<\/span>\uff08<span>kg<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2022<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">d<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff09\u5f3a\u7684\u677e\u7b49\u6548\u5242\u91cf\u53ca\u5176\u4ed6\u6cbb\u7597\uff0c\u76f4\u81f3\u6539\u5584\u5230\u2264<span>1<\/span>\u7ea7\u3002\u7cd6\u76ae\u8d28\u6fc0\u7d20\u9700\u81f3\u5c11\u4e00\u4e2a\u6708\u7684\u65f6\u95f4\u9010\u6e10\u51cf\u91cf\u76f4\u81f3\u505c\u836f\uff0c\u5feb\u901f\u51cf\u91cf\u53ef\u80fd\u5f15\u8d77\u4e0d\u826f\u53cd\u5e94\u6076\u5316\u6216\u590d\u53d1\u3002\u5982\u679c\u4e0d\u826f\u53cd\u5e94\u5728\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u540e\u7ee7\u7eed\u6076\u5316\u6216\u65e0\u6539\u5584\uff0c\u5219\u5e94\u589e\u52a0\u975e\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7c7b\u522b\u7684\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e<span>4<\/span>\u7ea7\u53ca\u67d0\u4e9b\u7279\u5b9a\u7684<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ca\u4efb\u4f55\u590d\u53d1\u6027<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u672b\u6b21\u7ed9\u836f\u540e<span>12<\/span>\u5468\u5185<span>2<\/span>\uff5e<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u672a\u6539\u5584\u5230<span>0<\/span>\uff5e<span>1<\/span>\u7ea7\uff08\u9664\u5916\u5185\u5206\u6ccc\u75be\u75c5\uff09\uff0c\u4ee5\u53ca\u672b\u6b21\u7ed9\u836f<span>12<\/span>\u5468\u5185\u7cd6\u76ae\u8d28\u6fc0\u7d20\u672a\u80fd\u964d\u81f3<span>\u226410mg\/d<\/span>\u5f3a\u7684\u677e\u7b49\u6548\u5242\u91cf\uff0c\u5e94\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7981\u5fcc\uff1a\uff08<span>1<\/span>\uff09\u7981\u6b62\u7528\u4e8e\u5bf9\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\u6d3b\u6027\u6210\u5206\u6216\u8f85\u6599\u5b58\u5728\u8d85\u654f\u53cd\u5e94\u7684\u60a3\u8005\u3002\uff08<span>2<\/span>\uff09\u4e0d\u53ef\u4e0e\u5176\u4ed6\u836f\u54c1\u6df7\u5408\u6216\u7a00\u91ca\uff0c\u836f\u74f6\u4e2d\u5269\u4f59\u7684\u836f\u7269\u4e0d\u53ef\u91cd\u590d\u4f7f\u7528\u3002\uff08<span>3<\/span>\uff09\u4e0d\u5f97\u91c7\u7528\u9759\u8109\u63a8\u6ce8\u6216\u5355\u6b21\u5feb\u901f\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56e0\u53ef\u80fd\u5e72\u6270\u672c\u54c1\u836f\u6548\u5b66\u6d3b\u6027\uff0c\u5e94\u907f\u514d\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002\u4f46\u662f\u5982\u679c\u4e3a\u4e86\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u540e\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e09\u3001\u5361\u745e\u5229\u73e0\u5355\u6297 <span>Camrelizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7c89\u9488\u5242\uff1a<span>200mg\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e8c\u7ebf\u53ca\u4ee5\u4e0a\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u665a\u671f\u9f3b\u54bd\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u8054\u5408\u987a\u94c2\u548c\u5409\u897f\u4ed6\u6ee8\u7528\u4e8e\u5c40\u90e8\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u5c40\u90e8\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>200mg\/<\/span>\u6b21\uff0c\u9759\u8109\u8f93\u6ce8\u6bcf<span>3<\/span>\u5468\u4e00\u6b21\uff0c\u76f4\u5230\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u5f71\u50cf\u5b66\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u533b\u751f\u53ef\u57fa\u4e8e\u5bf9\u60a3\u8005\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u8003\u8651\u662f\u5426\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5f53\u5361\u745e\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u7ed9\u836f\u65f6\uff0c\u5e94\u9996\u5148\u7ed9\u4e88\u5361\u745e\u5229\u73e0\u5355\u6297\u9759\u8109\u6ef4\u6ce8\uff0c\u95f4\u9694\u81f3\u5c11<span>30<\/span>\u5206\u949f\u540e\u518d\u7ed9\u4e88\u5316\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u662f\uff1a\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u3001<span>AST<\/span>\u5347\u9ad8\u3001<span>ALT<\/span>\u5347\u9ad8\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u3001\u4e4f\u529b\u3001\u86cb\u767d\u5c3f\u3001\u53d1\u70ed\u548c\u767d\u7ec6\u80de\u51cf\u5c11\u75c7\u3002\u5355\u836f\u6cbb\u7597\u6240\u62a5\u544a\u7684\u5927\u591a\u6570\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\u4e3a<span>1<\/span>\u7ea7\u6216<span>2<\/span>\u7ea7\uff0c\u6700\u5e38\u89c1\u7684\uff1e<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\u662f\uff1a\u8d2b\u8840\u3001\u4f4e\u94a0\u8840\u75c7\u3001\u03b3<span>&#8211;<\/span>\u8c37\u6c28\u9170\u8f6c\u79fb\u9176\u5347\u9ad8\u3001<span>AST<\/span>\u5347\u9ad8\u7b49\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u5927\u591a\u6570\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u662f\u53ef\u9006\u7684\uff0c\u4e14\u53ef\u901a\u8fc7\u4e2d\u65ad\u5361\u745e\u5229\u73e0\u5355\u6297\u5e76\u4f7f\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u652f\u6301\u6cbb\u7597\u3002\u5bf9\u4e8e\u5927\u90e8\u5206<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u53ca\u67d0\u4e9b\u7279\u5b9a\u7684<span>2<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u9700\u6682\u505c\u7ed9\u836f\uff0c\u5e76\u7ed9\u4e88<span>1<\/span>\uff5e<span>2mg\/<\/span>\uff08<span>kg<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2022<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">d<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff09\u5f3a\u7684\u677e\u7b49\u6548\u5242\u91cf\u53ca\u5176\u4ed6\u6cbb\u7597\uff0c\u76f4\u81f3\u6539\u5584\u5230\u2264<span>1<\/span>\u7ea7\u3002\u7cd6\u76ae\u8d28\u6fc0\u7d20\u9700\u81f3\u5c11\u4e00\u4e2a\u6708\u7684\u65f6\u95f4\u9010\u6e10\u51cf\u91cf\u76f4\u81f3\u505c\u836f\uff0c\u5feb\u901f\u51cf\u91cf\u53ef\u80fd\u5f15\u8d77\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u7684\u53cd\u590d\u3002\u5982\u679c\u4e0d\u826f\u53cd\u5e94\u5728\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u540e\u7ee7\u7eed\u6076\u5316\u6216\u65e0\u6539\u5584\uff0c\u5219\u5e94\u589e\u52a0\u7cd6\u76ae\u8d28\u6fc0\u7d20\u4ee5\u5916\u7684\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\uff0c\u5927\u591a\u53d1\u751f\u5728\u4f53\u8868\u76ae\u80a4\uff0c\u5c11\u6570\u53ef\u89c1\u4e8e\u53e3\u8154\u9ecf\u819c\u3001\u9f3b\u8154\u9ecf\u819c\u4ee5\u53ca\u773c\u7751\u7ed3\u819c\u3002\u53d1\u751f\u4e8e\u76ae\u80a4\u7684\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\uff0c\u521d\u59cb\u591a\u8868\u73b0\u4e3a\u4f53\u8868\u9c9c\u7ea2\u8272\u70b9\u72b6\u7269\uff0c\u76f4\u5f84\uff1c<span>2mm<\/span>\uff0c\u968f\u7740\u7528\u836f\u6b21\u6570\u589e\u52a0\uff0c\u75c5\u53d8\u8303\u56f4\u53ef\u9010\u6e10\u589e\u5927\uff0c\u591a\u4e3a\u7ed3\u8282\u72b6\uff0c\u4e5f\u6709\u6591\u7247\u72b6\uff0c\u989c\u8272\u9c9c\u7ea2\u6216\u6697\u7ea2\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e<span>4<\/span>\u7ea7\u53ca\u67d0\u4e9b\u7279\u5b9a\u7684<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ca\u4efb\u4f55\u590d\u53d1\u6027<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u672b\u6b21\u7ed9\u836f\u540e<span>12<\/span>\u5468\u5185<span>2<\/span>\uff5e<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u672a\u6539\u5584\u5230<span>0<\/span>\uff5e<span>1<\/span>\u7ea7\uff08\u9664\u5916\u5185\u5206\u6ccc\u75be\u75c5\uff09\uff0c\u4ee5\u53ca\u672b\u6b21\u7ed9\u836f<span>12<\/span>\u5468\u5185\u7cd6\u76ae\u8d28\u6fc0\u7d20\u672a\u80fd\u964d\u81f3\u2264<span>10mg\/d<\/span>\u5f3a\u7684\u677e\u7b49\u6548\u5242\u91cf\uff0c\u5e94\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56e0\u53ef\u80fd\u5e72\u6270\u672c\u54c1\u836f\u6548\u5b66\u6d3b\u6027\uff0c\u5e94\u907f\u514d\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u524d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002\u4f46\u662f\u5982\u679c\u4e3a\u4e86\u6cbb\u7597\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u5728\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u540e\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56db\u3001\u7d22\u62c9\u975e\u5c3c<span> Sorafenib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>200mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.6pt;vertical-align:middle;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u5c40\u90e8\u590d\u53d1\u6216\u8f6c\u79fb\u7684\u8fdb\u5c55\u6027\u7684\u653e\u5c04\u6027\u7898\u96be\u6cbb\u6027\u5206\u5316\u578b\u7532\u72b6\u817a\u764c\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7a7a\u8179\u7ed9\u836f\uff0c\u7528\u836f\u524d\u65e0\u9700\u8fdb\u884c\u57fa\u56e0\u68c0\u6d4b\u3002\u82e5\u957f\u671f\u75c5\u60c5\u7a33\u5b9a\uff0c\u4e0d\u9700\u670d\u7528\u6b64\u7c7b\u836f\u7269\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b58\u5728\u53ef\u7591\u7684\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u65f6\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u548c<span>\/<\/span>\u6216\u51cf\u5c11\u7d22\u62c9\u975e\u5c3c\u5242\u91cf\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u6709\u8179\u6cfb\uff0c\u4e4f\u529b\uff0c\u8131\u53d1\uff0c\u611f\u67d3\uff0c\u624b\u8db3\u76ae\u80a4\u53cd\u5e94\uff0c\u76ae\u75b9\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u7d22\u62c9\u975e\u5c3c\u6216\u672c\u54c1\u4efb\u4e00\u975e\u6d3b\u6027\u6210\u5206\u6709\u4e25\u91cd\u8fc7\u654f\u75c7\u72b6\u7684\u60a3\u8005\u7981\u7528\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0e<span>UGT1A1<\/span>\u9014\u5f84\u4ee3\u8c22<span>\/<\/span>\u6e05\u9664\u7684\u836f\u7269\u8054\u5408\u5e94\u7528\u65f6\uff0c\u9700\u8c28\u614e\uff1b\u4e0e\u591a\u897f\u4ed6\u8d5b\u8054\u5408\u5e94\u7528\u65f6\uff0c\u9700\u8c28\u614e\uff1b\u4e0e<span>CYP3A4<\/span>\u8bf1\u5bfc\u5242\u8054\u5408\u5e94\u7528\u65f6\u53ef\u5bfc\u81f4\u7d22\u62c9\u975e\u5c3c\u7684\u836f\u7269\u6d53\u5ea6\u964d\u4f4e\uff1b\u4e0e\u65b0\u9709\u7d20\u8054\u5408\u5e94\u7528\u53ef\u5bfc\u81f4\u7d22\u62c9\u975e\u5c3c\u7684\u66b4\u9732\u91cf\u4e0b\u964d\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e94\u3001\u4ed1\u4f10\u66ff\u5c3c<span> Lenvatinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>4mg<\/span>\u3001<span>10mg<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8fdb\u5c55\u6027\u3001\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u653e\u5c04\u6027\u7898\u96be\u6cbb\u5206\u5316\u578b\u7532\u72b6\u817a\u764c\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u65e5\u5242\u91cf\u4e3a<span>24mg<\/span>\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u5e94\u6301\u7eed\u6cbb\u7597\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u63a5\u53d7\u4ed1\u4f10\u66ff\u5c3c\u7684\u60a3\u8005\u4e2d\uff0c\u5e94\u8c28\u614e\u4f7f\u7528\u5df1\u77e5\u5177\u6709\u8f83\u7a84\u6cbb\u7597\u6307\u6570\u7684<span>CYP3A4<\/span>\u5e95\u7269\uff08\u4f8b\u5982\u963f\u53f8\u54aa\u5511\u3001\u7279\u975e\u90a3\u5b9a\u3001\u897f\u6c99\u5fc5\u5229\u3001\u5339\u83ab\u9f50\u7279\u3001\u594e\u5c3c\u4e01\u3001\u82c4\u666e\u5730\u5c14\uff09\u6216\u9ea6\u89d2\u751f\u7269\u78b1\uff08\u9ea6\u89d2\u80fa\u3001\u4e8c\u6c22\u9ea6\u89d2\u80fa\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u8fc7\u7a0b\u9700\u5bc6\u5207\u76d1\u6d4b\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f\u3002\u5728\u7532\u72b6\u817a\u764c\u6cbb\u7597\u4e2d\uff0c\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08\uff1e<span>30%<\/span>\uff09\u4e3a\u9ad8\u8840\u538b\u3001\u75b2\u4e4f\u3001\u8179\u6cfb\u3001\u5173\u8282\u75db<span>\/<\/span>\u808c\u75db\u3001\u98df\u6b32\u4e0b\u964d\u3001\u4f53\u91cd\u51cf\u8f7b\u3001\u6076\u5fc3\u3001\u53e3\u8154\u9ecf\u819c\u708e\u3001\u5934\u75db\u3001\u5455\u5410\u3001\u86cb\u767d\u5c3f\u7b49\u3002\u5fc5\u8981\u65f6\u51cf\u91cf\u3001\u6682\u505c\u7528\u836f\u6216\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e00\u65e6\u51fa\u73b0\u6301\u7eed\u6027\u6216\u4e0d\u53ef\u8010\u53d7\u7684<span>2<\/span>\uff5e<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u5f53\u6682\u505c\u7ed9\u836f\uff0c\u76f4\u81f3\u7f13\u89e3\u81f3<span>0<\/span>\uff5e<span>1<\/span>\u7ea7\u6216\u57fa\u7ebf\u6c34\u5e73\uff0c\u6309\u8c03\u6574\u540e\u51cf\u91cf\u63a8\u8350\uff1a<span>20mg\u219214mg\u219210mg<\/span>\u7684\u65e5\u5242\u91cf\u51cf\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e25\u91cd\u80be\u529f\u80fd\u635f\u4f24\u548c\u809d\u529f\u80fd\u635f\u4f24\u7684\u60a3\u8005\uff0c\u4ed1\u4f10\u66ff\u5c3c\u7684\u5242\u91cf\u5e94\u6539\u4e3a<span>10mg<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4ed1\u4f10\u66ff\u5c3c\u5e94\u5728\u6bcf\u5929\u56fa\u5b9a\u65f6\u95f4\u670d\u7528\uff0c\u7a7a\u8179\u6216\u4e0e\u98df\u7269\u540c\u670d\u5747\u53ef\u3002\u5982\u679c\u60a3\u8005\u9057\u6f0f\u4e00\u6b21\u7528\u836f\u4e14\u65e0\u6cd5\u5728<span>12<\/span>\u5c0f\u65f6\u5185\u670d\u7528\uff0c\u65e0\u9700\u8865\u670d\uff0c\u5e94\u6309\u5e38\u89c4\u7528\u836f\u65f6\u95f4\u8fdb\u884c\u4e0b\u4e00\u6b21\u670d\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u516d\u3001\u5b89\u7f57\u66ff\u5c3c <span>Anlotinib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>8mg<\/span>\u3001<span>10mg<\/span>\u3001<span>12mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u5177\u6709\u4e34\u5e8a\u75c7\u72b6\u6216\u660e\u786e\u75be\u75c5\u8fdb\u5c55\u7684\u3001\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u7532\u72b6\u817a\u9ad3\u6837\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c\u7684\u63a8\u8350\u5242\u91cf\u4e3a<span>12mg<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\/<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b21<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u65e9\u9910\u524d\u53e3\u670d\u3002\u8fde\u7eed\u670d\u836f<span>2<\/span>\u5468\uff0c\u505c\u836f<span>1<\/span>\u5468\uff0c\u5373<span>3<\/span>\u5468\uff08<span>21<\/span>\u5929\uff09\u4e3a\u4e00\u4e2a\u7597\u7a0b\u3002\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u4e0d\u826f\u53cd\u5e94\u3002\u7528\u836f\u671f\u95f4\u5982\u51fa\u73b0\u6f0f\u670d\uff0c\u786e\u8ba4\u8ddd\u4e0b\u6b21\u7528\u836f\u65f6\u95f4\u77ed\u4e8e<span>12<\/span>\u5c0f\u65f6\uff0c\u5219\u4e0d\u518d\u8865\u670d\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u5e94\u5bc6\u5207\u76d1\u6d4b\u4e0d\u826f\u53cd\u5e94\uff0c\u5e76\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u60c5\u51b5\u8fdb\u884c\u8c03\u6574\u4ee5\u4f7f\u60a3\u8005\u80fd\u591f\u8010\u53d7\u6cbb\u7597\u3002\u672c\u54c1\u6240\u81f4\u7684\u4e0d\u826f\u53cd\u5e94\u53ef\u901a\u8fc7\u5bf9\u75c7\u6cbb\u7597\u3001\u6682\u505c\u7528\u836f\u548c<span>\/<\/span>\u6216\u8c03\u6574\u5242\u91cf\u7b49\u65b9\u5f0f\u5904\u7406\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7a0b\u5ea6\u5206\u7ea7\u7ba1\u7406\uff08\u975e\u51fa\u8840\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\uff09\u3002\u5982\u51fa\u73b0<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\u9700\u6682\u505c\u7528\u836f\uff0c\u76f4\u81f3\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u81f3\uff1c<span>2<\/span>\u7ea7\u540e\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\uff08<span>12mg<\/span>\u2192<span>10mg<\/span>\u2192<span>8mg<\/span>\uff09\u7ee7\u7eed\u7528\u836f\uff0c\u82e5\u4e0d\u826f\u53cd\u5e94\u6301\u7eed\u8d85\u8fc7<span>2<\/span>\u5468\u5219\u6c38\u4e45\u505c\u836f\u3002\u5982\u51fa\u73b0<span>4<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\u5e94\u8003\u8651\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5b89\u7f57\u66ff\u5c3c\u7684\u91cd\u8981\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\uff1a\u51fa\u8840\u3001\u9ad8\u8840\u538b\u3001\u86cb\u767d\u5c3f\u3001\u624b\u8db3\u7efc\u5408\u5f81\u3001\u8179\u6cfb\u3001\u5fc3\u808c\u7f3a\u8840\u7b49\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u6cbb\u7597\u671f\u95f4\u5e94\u5bf9\u60a3\u8005\u7684\u51fa\u8840\u76f8\u5173\u4f53\u5f81\u548c\u75c7\u72b6\u8fdb\u884c\u76d1\u6d4b\u3002\u5177\u6709\u51fa\u8840\u98ce\u9669\u3001\u51dd\u8840\u529f\u80fd\u5f02\u5e38\u7684\u60a3\u8005\u5e94\u614e\u7528\uff0c\u670d\u7528\u671f\u95f4\u5e94\u4e25\u5bc6\u76d1\u6d4b\u8840\u5c0f\u677f\u3001\u51dd\u8840\u9176\u539f\u65f6\u95f4\u3002\u51fa\u73b0<span>2<\/span>\u7ea7\u51fa\u8840\u4e8b\u4ef6\u7684\u60a3\u8005\u5e94\u6682\u505c\u5b89\u7f57\u66ff\u5c3c\u6cbb\u7597\uff0c\u5982\u4e24\u5468\u5185\u6062\u590d\u81f3\uff1c<span>2<\/span>\u7ea7\uff0c\u5219\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u7ee7\u7eed\u7528\u836f\u3002\u5982\u518d\u6b21\u51fa\u8840\uff0c\u5e94\u6c38\u4e45\u505c\u836f\u3002\u4e00\u65e6\u51fa\u73b0<span>3<\/span>\u7ea7\u6216\u4ee5\u4e0a\u7684\u51fa\u8840\u4e8b\u4ef6\uff0c\u5219\u6c38\u4e45\u505c\u836f\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56e0\u4e34\u5e8a\u8bd5\u9a8c\u6392\u9664\u4e86\u5b58\u5728\u51fa\u8840\u4f53\u8d28\u8ff9\u8c61\u6216\u75c5\u53f2\u3001\u7528\u836f\u524d<span>4<\/span>\u5468\u5185\u51fa\u73b0\u2265<span>3<\/span>\u7ea7\u7684\u4efb\u4f55\u51fa\u8840\u4e8b\u4ef6\u3001\u5b58\u5728\u672a\u6108\u5408\u521b\u53e3\u3001\u6e83\u75a1\u6216\u9aa8\u6298\uff0c\u56e0\u6b64\u5177\u6709\u4ee5\u4e0a\u98ce\u9669\u7684\u60a3\u8005\u5e94\u5728\u533b\u5e08\u6307\u5bfc\u4e0b\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e03\u3001\u7eb3\u6b66\u5229\u5c24\u5355\u6297<span> Nivolumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">40mg<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08<span>4ml<\/span>\uff09<span>\/<\/span>\u74f6\u3001<span>100mg<\/span>\uff08<span>10ml<\/span>\uff09<span>\/<\/span>\u74f6<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u9002\u7528\u4e8e\u6cbb\u7597\u63a5\u53d7\u542b\u94c2\u7c7b\u65b9\u6848\u6cbb\u7597\u671f\u95f4\u6216\u4e4b\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u4e14\u80bf\u7624<span>PD-L1<\/span>\u8868\u8fbe\u9633\u6027\uff08\u5b9a\u4e49\u4e3a\u8868\u8fbe<span>PD-L1<\/span>\u7684\u80bf\u7624\u7ec6\u80de\u2265<span>1%<\/span>\uff09\u7684\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u63a5\u53d7\u542b\u94c2\u7c7b\u65b9\u6848\u6cbb\u7597\u671f\u95f4\u6216\u4e4b\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u4e14\u80bf\u7624<span>PD-L1<\/span>\u8868\u8fbe\u9633\u6027\uff08\u5b9a\u4e49\u4e3a\u8868\u8fbe<span>PD-L1<\/span>\u7684\u80bf\u7624\u7ec6\u80de\u2265<span>1%<\/span>\uff09\u7684\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u63a8\u8350\u7ed9\u836f\u65b9\u6848\u4e3a<span>3mg\/kg<\/span>\u6216<span>240mg<\/span>\u56fa\u5b9a\u5242\u91cf\uff0c\u9759\u8109\u6ce8\u5c04\uff0c\u6301\u7eed<span>30<\/span>\u5206\u949f\uff0c\u6bcf<span>2<\/span>\u5468\u4e00\u6b21\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4ea7\u751f\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u53ea\u8981\u89c2\u5bdf\u5230\u4e34\u5e8a\u83b7\u76ca\uff0c\u5e94\u7ee7\u7eed\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u60a3\u8005\u4e0d\u80fd\u8010\u53d7\u3002\u6709\u53ef\u80fd\u89c2\u5bdf\u5230\u975e\u5178\u578b\u53cd\u5e94\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\u6216\u6301\u7eed\u51cf\u8f7b\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u505c\u836f\uff0c\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u53ef\u5f15\u8d77\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u6301\u7eed\u8fdb\u884c\u60a3\u8005\u76d1\u6d4b\uff08\u81f3\u5c11\u81f3\u672b\u6b21\u7ed9\u836f\u540e<span>5<\/span>\u4e2a\u6708\uff09\uff0c\u56e0\u4e3a\u4e0d\u826f\u53cd\u5e94\u53ef\u80fd\u5728\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u671f\u95f4\u6216\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u505c\u6b62\u540e\u7684\u4efb\u4f55\u65f6\u95f4\u53d1\u751f\u3002\u5bf9\u4e8e\u7591\u4f3c\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u8ba4\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u5e94\u6682\u505c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u5e76\u7ed9\u4e88\u7cd6\u76ae\u8d28\u6fc0\u7d20\u3002\u82e5\u4f7f\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u514d\u75ab\u6291\u5236\u7597\u6cd5\u6cbb\u7597\u4e0d\u826f\u53cd\u5e94\uff0c\u75c7\u72b6\u6539\u5584\u540e\uff0c\u9700\u81f3\u5c11<span>1<\/span>\u4e2a\u6708\u7684\u65f6\u95f4\u9010\u6e10\u51cf\u91cf\u81f3\u505c\u836f\u3002\u5feb\u901f\u51cf\u91cf\u53ef\u80fd\u5f15\u8d77\u4e0d\u826f\u53cd\u5e94\u6076\u5316\u6216\u590d\u53d1\u3002\u5982\u679c\u867d\u4f7f\u7528\u4e86\u7cd6\u76ae\u8d28\u6fc0\u7d20\u4f46\u4ecd\u6076\u5316\u6216\u65e0\u6539\u5584\uff0c\u5219\u5e94\u589e\u52a0\u975e\u7cd6\u76ae\u8d28\u6fc0\u7d20\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u3002\u5728\u60a3\u8005\u63a5\u53d7\u514d\u75ab\u6291\u5236\u5242\u91cf\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u671f\u95f4\uff0c\u4e0d\u53ef\u91cd\u65b0\u4f7f\u7528\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u3002\u5728\u63a5\u53d7\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u5e94\u4f7f\u7528\u9884\u9632\u6027\u6297\u751f\u7d20\u9884\u9632\u673a\u4f1a\u6027\u611f\u67d3\u3002\u82e5\u51fa\u73b0\u4efb\u4f55\u91cd\u5ea6\u3001\u590d\u53d1\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u4ee5\u53ca\u4efb\u4f55\u5371\u53ca\u751f\u547d\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5fc5\u987b\u6c38\u4e45\u505c\u6b62\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u51fa\u73b0\u8f7b\u4e2d\u5ea6\u8f93\u6db2\u53cd\u5e94\u7684\u60a3\u8005\u5728\u63a5\u53d7\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u65f6\u5e94\u5bc6\u5207\u76d1\u6d4b\uff0c\u5e76\u4f9d\u7167\u8f93\u6db2\u53cd\u5e94\u7684\u6cbb\u7597\u6307\u5357\u9884\u9632\u7528\u836f\u3002\u5982\u679c\u51fa\u73b0\u91cd\u5ea6\u6216\u5371\u53ca\u751f\u547d\u7684\u8f93\u6db2\u53cd\u5e94\uff0c\u5fc5\u987b\u505c\u6b62\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\uff0c\u7ed9\u4e88\u9002\u5f53\u7684\u836f\u7269\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6709\u53ef\u80fd\u4f1a\u7ecf\u6bcd\u4f53\u4f20\u8f93\u81f3\u53d1\u80b2\u4e2d\u7684\u80ce\u513f\u3002\u4e0d\u5efa\u8bae\u5728\u598a\u5a20\u671f\u95f4\u3001\u5728\u4e0d\u91c7\u7528\u6709\u6548\u907f\u5b55\u63aa\u65bd\u7684\u80b2\u9f84\u671f\u5973\u6027\u4e2d\u4f7f\u7528\u7eb3\u6b66\u5229\u5c24\u5355\u6297\uff0c\u9664\u975e\u4e34\u5e8a\u83b7\u76ca\u5927\u4e8e\u6f5c\u5728\u98ce\u9669\u3002\u5e94\u5728\u6700\u540e\u4e00\u6b21\u5e94\u7528\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u540e\u81f3\u5c11<span>5<\/span>\u4e2a\u6708\u5185\u91c7\u7528\u6709\u6548\u907f\u5b55\u63aa\u65bd\u3002\u65e0\u6cd5\u6392\u9664\u4f1a\u5bf9\u65b0\u751f\u513f<span>\/<\/span>\u5a74\u513f\u9020\u6210\u98ce\u9669\uff0c\u5728\u8003\u8651\u6bcd\u4e73\u5582\u517b\u5bf9\u5b69\u5b50\u7684\u76ca\u5904\u4ee5\u53ca\u6cbb\u7597\u5bf9\u5987\u5973\u7684\u76ca\u5904\u540e\uff0c\u5fc5\u987b\u505a\u51fa\u662f\u505c\u6b62\u6bcd\u4e73\u5582\u517b\u8fd8\u662f\u505c\u6b62\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u7684\u51b3\u5b9a\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c1a\u672a\u786e\u7acb\u672c\u54c1\u5728<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u5728\u8001\u5e74\u4eba\u7fa4\u4e2d\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u7684\u6570\u636e\u6709\u9650\u3002\u8f7b\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u6ca1\u6709\u5bf9\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u8fdb\u884c\u672c\u54c1\u7684\u76f8\u5173\u7814\u7a76\uff0c\u91cd\u5ea6\uff08\u603b\u80c6\u7ea2\u7d20\uff1e<span>3<\/span>\u500d<span>ULN<\/span>\uff09\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u5fc5\u987b\u614e\u7528\u672c\u54c1\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u907f\u514d\u5728\u57fa\u7ebf\u5f00\u59cb\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u524d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u516b\u3001\u897f\u59a5\u6614\u5355\u6297 <span>Cetuximab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>20ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u7528\u4e8e\u6cbb\u7597\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\uff1a\u4e0e\u94c2\u7c7b\u548c\u6c1f\u5c3f\u5627\u5576\u5316\u7597\u8054\u5408\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u590d\u53d1\u548c<span>\/<\/span>\u6216\u8f6c\u79fb\u6027\u75be\u75c5\u3002<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5fc5\u987b\u5728\u6709\u6297\u80bf\u7624\u836f\u7269\u4f7f\u7528\u7ecf\u9a8c\u7684\u533b\u5e08\u6307\u5bfc\u4e0b\u4f7f\u7528\u3002\u5728\u7528\u836f\u8fc7\u7a0b\u4e2d\u53ca\u7528\u836f\u7ed3\u675f\u540e<span>1<\/span>\u5c0f\u65f6\u5185\uff0c\u9700\u5bc6\u5207\u76d1\u6d4b\u60a3\u8005\u7684\u72b6\u51b5\uff0c\u5e76\u5fc5\u987b\u914d\u5907\u590d\u82cf\u8bbe\u5907\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u5e94\u50a8\u5b58\u5728<span>2<\/span>\uff5e<span>8<\/span>\u2103\uff0c\u5f00\u542f\u540e\u5e94\u7acb\u5373\u4f7f\u7528\uff0c\u7981\u6b62\u51b7\u51bb\u3002\u8bf7\u7f6e\u4e8e\u513f\u7ae5\u4e0d\u53ef\u89e6\u53ca\u5904\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u9996\u6b21\u6ef4\u6ce8\u672c\u54c1\u4e4b\u524d\u81f3\u5c11<span>1<\/span>\u5c0f\u65f6\uff0c\u60a3\u8005\u5fc5\u987b\u63a5\u53d7\u6297\u7ec4\u80fa\u836f\u7269\u548c<span>\/<\/span>\u6216\u7cd6\u76ae\u8d28\u6fc0\u7d20\u836f\u7269\u7684\u9884\u9632\u7528\u836f\u3002\u5efa\u8bae\u5728\u540e\u7eed\u6cbb\u7597\u4e2d\uff0c\u6bcf\u6b21\u4f7f\u7528\u672c\u54c1\u524d\u90fd\u7ed9\u4e88\u60a3\u8005\u4e0a\u8ff0\u9884\u9632\u7528\u836f\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6240\u6709\u9002\u5e94\u8bc1\uff0c\u672c\u54c1\u6bcf\u5468\u7ed9\u836f\u4e00\u6b21\u3002\u521d\u59cb\u5242\u91cf\u6309\u4f53\u8868\u9762\u79ef\u4e3a<span>400mg\/<\/span>\u33a1\uff0c\u4e4b\u540e\u6bcf\u5468\u7ed9\u836f\u5242\u91cf\u6309\u4f53\u8868\u9762\u79ef\u4e3a<span>250mg\/<\/span>\u33a1\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u4e0e\u94c2\u7c7b\u5316\u5408\u7269\u4e3a\u57fa\u7840\u7684\u5316\u7597\u836f\u7269\u8054\u5408\u5e94\u7528\u4e8e\u590d\u53d1\u548c<span>\/<\/span>\u6216\u8f6c\u79fb\u6027\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u7684\u6cbb\u7597\uff0c\u968f\u540e\u7ee7\u7eed\u4f7f\u7528\u672c\u54c1\u8fdb\u884c\u7ef4\u6301\u6cbb\u7597\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u3002\u5316\u7597\u836f\u7269\u7684\u4f7f\u7528\u5fc5\u987b\u5728\u672c\u54c1\u6ef4\u6ce8\u7ed3\u675f<span>1<\/span>\u5c0f\u65f6\u4e4b\u540e\u5f00\u59cb\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e0\u8bba<span>EGFR<\/span>\u7684\u8868\u8fbe\u72b6\u51b5\u5982\u4f55\uff0c\u6240\u6709\u6709\u6548\u6027\u7ec8\u70b9\u5747\u8bc1\u5b9e\u6709\u4e34\u5e8a\u83b7\u76ca\u3002\u5c1a\u65e0\u8bc1\u636e\u8bc1\u5b9e<span>EGFR<\/span>\u8868\u8fbe\u7b49\u76f8\u5173\u6807\u5fd7\u7269\u68c0\u6d4b\u80fd\u9884\u6d4b\u672c\u54c1\u5728\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u4e2d\u7684\u7597\u6548\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5168\u7403\u7814\u7a76\uff08<span>EXTREME<\/span>\uff09\u662f\u4e00\u9879\u7eb3\u5165<span>442<\/span>\u4f8b\u5c40\u90e8\u590d\u53d1\u548c<span>\/<\/span>\u6216\u8f6c\u79fb\u6027\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u7684\u591a\u4e2d\u5fc3\u2162\u671f\u7814\u7a76\u3002\u4e2d\u56fd\u7814\u7a76\uff08<span>CHANGE2<\/span>\uff09\u662f\u4e00\u7ebf\u6cbb\u7597\u4e2d\u56fd\u5934\u9888\u90e8\u590d\u53d1\u6027\u548c<span>\/<\/span>\u6216\u8f6c\u79fb\u6027\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u2162\u671f\u7814\u7a76\u3002<span>CHANGE2<\/span>\u7684\u6709\u6548\u6027\u7ed3\u679c\u4e0e<span>EXTREME<\/span>\u7ed3\u679c\u4e00\u81f4\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u53ef\u4f7f\u7528\u8f93\u6db2\u6cf5\u3001\u91cd\u529b\u6ef4\u6ce8\u6216\u6ce8\u5c04\u6cf5\u8fdb\u884c\u9759\u8109\u7ed9\u836f\u3002\u9996\u6b21\u7ed9\u836f\u5e94\u7f13\u6162\uff0c\u6ef4\u6ce8\u901f\u5ea6\u4e0d\u5f97\u8d85\u8fc7<span>5mg\/min<\/span>\u3002\u5efa\u8bae\u6ef4\u6ce8\u65f6\u95f4\u4e3a<span>120<\/span>\u5206\u949f\uff0c\u968f\u540e\u6bcf\u5468\u7ed9\u836f\u7684\u6ef4\u6ce8\u65f6\u95f4\u4e3a<span>60<\/span>\u5206\u949f\uff0c\u6ef4\u6ce8\u901f\u5ea6\u4e0d\u5f97\u8d85\u8fc7<span>10mg\/min<\/span>\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u7684\u4e3b\u8981\u4e0d\u826f\u53cd\u5e94\u6709\u76ae\u80a4\u53cd\u5e94\uff0c\u53d1\u751f\u7387\u7ea6<span>80%<\/span>\u4ee5\u4e0a\uff0c\u7ea6\u8d85\u8fc7<span>10%<\/span>\u7684\u60a3\u8005\u53d1\u751f\u4f4e\u9541\u8840\u75c7\uff0c<span>10%<\/span>\u4ee5\u4e0a\u60a3\u8005\u53d1\u751f\u8f7b\u4e2d\u5ea6\u7684\u8f93\u6db2\u53cd\u5e94\uff0c<span>1%<\/span>\u4ee5\u4e0a\u7684\u60a3\u8005\u4f1a\u53d1\u751f\u91cd\u5ea6\u8f93\u6db2\u53cd\u5e94\u3002<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5c1a\u65e0\u513f\u7ae5\u60a3\u8005\u7684\u7528\u836f\u7ecf\u9a8c\uff0c\u672a\u786e\u7acb\u672c\u54c1\u5728\u672a\u6ee1<span>18<\/span>\u5c81\u60a3\u8005\u4e2d\u7684\u6709\u6548\u6027\u3002\u8001\u5e74\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002<span>75<\/span>\u5c81\u4ee5\u4e0a\u60a3\u8005\u7684\u7528\u836f\u7ecf\u9a8c\u6709\u9650\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">11.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u6027\u8d28\u4e0d\u4f1a\u53d7\u79cd\u65cf\u3001\u5e74\u9f84\u3001\u6027\u522b\u3001\u809d\u80be\u72b6\u51b5\u7684\u5f71\u54cd\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u4ec5\u5bf9\u809d\u80be\u529f\u80fd\u6b63\u5e38\u7684\u60a3\u8005\u8fdb\u884c\u8fc7\u672c\u54c1\u7684\u76f8\u5173\u7814\u7a76\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u4e5d\u3001\u5e15\u535a\u5229\u73e0\u5355\u6297 <span>Pembrolizumab<\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\u5c04\u6db2\uff1a<span>100mg<\/span>\uff08<span>4ml<\/span>\uff09<span>\/<\/span>\u74f6<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u4e8e\u901a\u8fc7\u5145\u5206\u9a8c\u8bc1\u7684\u68c0\u6d4b\u8bc4\u4f30\u80bf\u7624\u8868\u8fbe<span>PD-L1<\/span>\uff08\u7efc\u5408\u9633\u6027\u8bc4\u5206\u2265<span>20<\/span>\uff09\u7684\u8f6c\u79fb\u6027\u6216\u4e0d\u53ef\u5207\u9664\u7684\u590d\u53d1\u6027\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<\/span><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u590d\u53d1<span>\/<\/span>\u8f6c\u79fb\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u4e00\u7ebf\u9002\u5e94\u8bc1\u662f\u57fa\u4e8e\u5168\u7403\u2162\u671f<span>KEYNOTE-048<\/span>\u4e34\u5e8a\u7814\u7a76\u7684\u7ed3\u679c\u3002\u5e15\u535a\u5229\u73e0\u5355\u6297\u901a\u8fc7\u9759\u8109\u6ce8\u5c04\u7ed9\u836f<span>200mg<\/span>\u56fa\u5b9a\u5242\u91cf\uff0c\u9759\u8109\u8f93\u6ce8<span>30<\/span>\u5206\u949f\u4ee5\u4e0a\uff0c\u6bcf<span>3<\/span>\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u5e15\u535a\u5229\u73e0\u5355\u6297\u5355\u836f\u65b9\u6848\u5df2\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u548c<span>FDA<\/span>\u6279\u51c6\uff0c\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u65b9\u6848\u5df2\u83b7\u5f97\u7f8e\u56fd<span>FDA<\/span>\u6279\u51c6\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u7a33\u5b9a\uff0c\u5373\u4f7f\u6709\u75be\u75c5\u8fdb\u5c55\u7684\u521d\u6b65\u8bc1\u636e\uff0c\u4f46\u57fa\u4e8e\u603b\u4f53\u4e34\u5e8a\u83b7\u76ca\u7684\u5224\u65ad\uff0c\u53ef\u8003\u8651\u7ee7\u7eed\u5e94\u7528\u672c\u54c1\u6cbb\u7597\uff0c\u76f4\u81f3\u8bc1\u5b9e\u75be\u75c5\u8fdb\u5c55\u3002\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u6682\u505c\u7ed9\u836f\u6216\u505c\u836f\uff0c\u4e0d\u5efa\u8bae\u589e\u52a0\u6216\u51cf\u5c11\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u4e3b\u8981\u4e0d\u826f\u53cd\u5e94\u662f\u75b2\u52b3\u3001\u7619\u75d2\u3001\u8179\u6cfb\u548c\u76ae\u75b9\u3002\u63a5\u53d7\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u53ef\u53d1\u751f\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u4e25\u91cd\u548c\u81f4\u6b7b\u75c5\u4f8b\u3002\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u53ef\u540c\u65f6\u53d1\u751f\u5728\u591a\u4e2a\u5668\u5b98\u7cfb\u7edf\uff0c\u9700\u8981\u5bf9\u4e8e\u7591\u4f3c\u75c5\u4f8b\u8fdb\u884c\u5145\u5206\u7684\u8bc4\u4f30\u4ee5\u786e\u5b9a\u75c5\u56e0\u6216\u6392\u9664\u5176\u4ed6\u75c5\u56e0\u3002\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u5e94\u6682\u65f6\u505c\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\uff0c\u5e76\u5e94\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u3002\u5f53\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u6539\u5584\u81f3\u2264<span>1<\/span>\u7ea7\u65f6\uff0c\u9700\u81f3\u5c11\u4e00\u4e2a\u6708\u7684\u65f6\u95f4\u9010\u6b65\u51cf\u5c11\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7684\u7528\u91cf\u76f4\u81f3\u505c\u836f\u3002\u5018\u82e5\u53d1\u751f\u7cd6\u76ae\u8d28\u6fc0\u7d20\u65e0\u6cd5\u63a7\u5236\u7684\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u65f6\uff0c\u53ef\u4ee5\u8003\u8651\u4f7f\u7528\u5176\u4ed6\u5168\u8eab\u6027\u514d\u75ab\u6291\u5236\u5242\u3002\u5982\u679c\u4e0d\u826f\u53cd\u5e94\u4fdd\u6301\u5728\u2264<span>1<\/span>\u7ea7\uff0c\u4e14\u7cd6\u76ae\u8d28\u6fc0\u7d20\u5242\u91cf\u5df2\u964d\u81f3\u2264<span>10mg<\/span>\u6cfc\u5c3c\u677e\u6216\u7b49\u6548\u5242\u91cf\uff0c\u53ef\u5728\u6700\u540e\u4e00\u6b21\u4f7f\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ed9\u836f\u540e<span>12<\/span>\u5468\u5185\u91cd\u65b0\u5f00\u59cb\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u3002\u5bf9\u4e8e\u4efb\u4f55\u590d\u53d1\u6027<span>3<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u4ee5\u53ca\u4efb\u4f55<span>4<\/span>\u7ea7\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u6c38\u4e45\u505c\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u51fa\u73b0\u8f7b\u4e2d\u5ea6\u8f93\u6db2\u53cd\u5e94\u7684\u60a3\u8005\u5728\u5bc6\u5207\u76d1\u6d4b\u4e0b\u53ef\u7ee7\u7eed\u63a5\u53d7\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\uff0c\u53ef\u8003\u8651\u7528\u89e3\u70ed\u9547\u75db\u7c7b\u6297\u708e\u836f\u548c\u6297\u7ec4\u80fa\u836f\u9884\u9632\u3002\u5bf9\u4e8e\u91cd\u5ea6\u7684\u8f93\u6db2\u53cd\u5e94\uff0c\u5fc5\u987b\u505c\u6b62\u8f93\u6db2\u5e76\u6c38\u4e45\u505c\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5b55\u5987\u5728\u598a\u5a20\u671f\u4f7f\u7528\u53ef\u80fd\u4f1a\u5bf9\u80ce\u513f\u9020\u6210\u4f24\u5bb3\uff0c\u9664\u975e\u5b55\u5987\u7684\u4e34\u5e8a\u75be\u75c5\u9700\u8981\uff0c\u598a\u5a20\u671f\u4e0d\u5f97\u7528\u836f\u3002\u5efa\u8bae\u80b2\u9f84\u5973\u6027\u5728\u7528\u836f\u671f\u95f4\u91c7\u7528\u9ad8\u6548\u907f\u5b55\u65b9\u6cd5\uff0c\u5e76\u5728\u6700\u540e\u4e00\u6b21\u7528\u836f\u540e\u56db\u4e2a\u6708\u5185\u6301\u7eed\u907f\u5b55\u3002\u4e0d\u80fd\u6392\u9664\u672c\u54c1\u5bf9\u65b0\u751f\u513f\u7684\u98ce\u9669\uff0c\u5e94\u6743\u8861\u54fa\u4e73\u5bf9\u80ce\u513f\u7684\u83b7\u76ca\u4ee5\u53ca\u672c\u54c1\u6cbb\u7597\u5bf9\u5973\u6027\u60a3\u8005\u7684\u83b7\u76ca\u6765\u51b3\u7b56\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5c1a\u672a\u786e\u5b9a<span>18<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u4f7f\u7528\u672c\u54c1\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6027\uff0c\u5728\u8001\u5e74\u4eba\u7fa4\u4e2d\u4e0d\u9700\u8981\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8c03\u6574\u5242\u91cf\uff0c\u5c1a\u672a\u5728\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u4e2d\u8fdb\u884c\u672c\u54c1\u7684\u76f8\u5173\u7814\u7a76\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u5728\u4f7f\u7528\u8be5\u836f\u524d\u907f\u514d\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u3002<span><\/span><\/span>\n<\/p>\n<p><b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><br \/>\n<\/span><\/b> <\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u751f\u6b96\u7cfb\u7edf\u80bf\u7624\u7528\u836f<\/span><\/b><b><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e00\u3001\u5965\u62c9\u5e15\u5229<span> Olaparib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7247\u5242\uff1a<span>100mg<\/span>\u3001<span>150mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u643a\u5e26\u80da\u7cfb\u6216\u4f53\u7ec6\u80de<span>BRCA<\/span>\u7a81\u53d8\u665a\u671f\u4e0a\u76ae\u6027\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u764c\u521d\u6cbb\u6210\u4eba\u60a3\u8005\u5728\u4e00\u7ebf\u542b\u94c2\u5316\u7597\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u6216\u90e8\u5206\u7f13\u89e3\u540e\u7684\u7ef4\u6301\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u94c2\u654f\u611f\u7684\u590d\u53d1\u6027\u4e0a\u76ae\u6027\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u764c\u6210\u4eba\u60a3\u8005\u5728\u542b\u94c2\u5316\u7597\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u6216\u90e8\u5206\u7f13\u89e3\u540e\u7684\u7ef4\u6301\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u5e76\u540c\u6e90\u91cd\u7ec4\u4fee\u590d\u7f3a\u9677\u9633\u6027\u7684\u665a\u671f\u4e0a\u76ae\u6027\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u764c\u521d\u6cbb\u6210\u4eba\u60a3\u8005\u5728\u4e00\u7ebf\u542b\u94c2\u5316\u7597\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u6216\u90e8\u5206\u7f13\u89e3\u540e\u4e0e\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408\u8fdb\u884c\u7684\u7ef4\u6301\u6cbb\u7597\uff08\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5c1a\u672a\u6279\u51c6\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u643a\u5e26\u80da\u7cfb<span>BRCA<\/span>\u7a81\u53d8\u3001\u7ecf\u8fc7\u4e09\u7ebf\u6216\u66f4\u591a\u7ebf\u5316\u7597\u7684\u665a\u671f\u5375\u5de2\u764c\u6210\u4eba\u60a3\u8005\uff08\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5c1a\u672a\u6279\u51c6\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5965\u62c9\u5e15\u5229\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u65b9\u6848\u7528\u4e8e\u4e00\u7ebf\u7ef4\u6301\u6cbb\u7597\u7684\u9002\u5e94\u8bc1\u57fa\u4e8e\u2162\u671f<span>PAOLA-1<\/span>\u7814\u7a76\u7ed3\u679c\uff1b\u5965\u62c9\u5e15\u5229\u7528\u4e8e\u540e\u7ebf\u5375\u5de2\u764c\u6cbb\u7597\u7684\u9002\u5e94\u8bc1\u57fa\u4e8e\u2162\u671f<span>SOLO-3<\/span>\u7814\u7a76\u7ed3\u679c\u3002\u4ee5\u4e0a\u9002\u5e94\u8bc1\u5df2\u83b7\u5f97\u7f8e\u56fd<span>FDA<\/span>\u6279\u51c6\uff0c\u4f46\u76ee\u524d\u5c1a\u672a\u5f97\u5230\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u7684\u83b7\u6279\uff0c\u53ef\u5728\u4e0e\u60a3\u8005\u5145\u5206\u6c9f\u901a\u7684\u60c5\u51b5\u4e0b\u8003\u8651\u4f7f\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a\u6b63\u5e38\u6210\u4eba<span>300mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u5373\u6bcf\u5929\u603b\u5242\u91cf\u4e3a<span>600mg<\/span>\u3002\u5e94\u5728\u542b\u94c2\u5316\u7597\u7ed3\u675f\u540e\u7684<span>8<\/span>\u5468\u5185\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u3002\u63a8\u8350\u7597\u7a0b\uff1a<span>BRCA<\/span>\u7a81\u53d8\u7684\u665a\u671f\u5375\u5de2\u764c\u7684\u4e00\u7ebf\u7ef4\u6301\u6cbb\u7597\u53ef\u6301\u7eed\u6cbb\u7597\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u53d1\u751f\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u53cd\u5e94\uff0c\u6216\u5b8c\u6210<span>2<\/span>\u5e74\u6cbb\u7597\u3002<span>2<\/span>\u5e74\u6cbb\u7597\u540e\uff0c\u5b8c\u5168\u7f13\u89e3\uff08\u5f71\u50cf\u5b66\u65e0\u80bf\u7624\u8bc1\u636e\uff09\u7684\u60a3\u8005\u5e94\u505c\u6b62\u6cbb\u7597\uff0c\u5f71\u50cf\u5b66\u663e\u793a\u6709\u80bf\u7624\u4e14\u4e34\u5e8a\u533b\u751f\u8ba4\u4e3a\u60a3\u8005\u80fd\u4ece\u6301\u7eed\u6cbb\u7597\u4e2d\u8fdb\u4e00\u6b65\u83b7\u76ca\u7684\u60c5\u51b5\u4e0b\u53ef\u4ee5\u7ee7\u7eed\u6cbb\u7597\u8d85\u8fc7<span>2<\/span>\u5e74\u3002\u94c2\u654f\u611f\u7684\u590d\u53d1\u6027\u5375\u5de2\u764c\u7684\u7ef4\u6301\u6cbb\u7597\u53ef\u6301\u7eed\u6cbb\u7597\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u53d1\u751f\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e94\u6574\u7247\u541e\u670d\uff0c\u4e0d\u5e94\u5480\u56bc\u3001\u538b\u788e\u3001\u6eb6\u89e3\u6216\u63b0\u65ad\u836f\u7247\u3002\u5728\u8fdb\u9910\u6216\u7a7a\u8179\u65f6\u5747\u53ef\u670d\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u60a3\u8005\u6f0f\u670d\u4e00\u5242\u836f\u7269\uff0c\u65e0\u9700\u8865\u670d\uff0c\u4ecd\u6309\u8ba1\u5212\u65f6\u95f4\u6b63\u5e38\u670d\u7528\u4e0b\u4e00\u5242\u91cf\uff0c\u5e76\u4e0d\u5f71\u54cd\u6574\u4f53\u7597\u6548\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u60a3\u8005\u5e94\u5728\u65e2\u5f80\u6297\u80bf\u7624\u6cbb\u7597\u5f15\u8d77\u7684\u8840\u6db2\u5b66\u6bd2\u6027\u6062\u590d\u4e4b\u540e\uff08\u8840\u7ea2\u86cb\u767d\u3001\u8840\u5c0f\u677f\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u6c34\u5e73\u5e94\u6062\u590d\u81f3\u2264<span>CTCAE 1<\/span>\u7ea7\uff09\uff0c\u624d\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u3002\u5728\u6cbb\u7597\u6700\u521d\u7684<span>12<\/span>\u4e2a\u6708\u5185\uff0c\u63a8\u8350\u5728\u57fa\u7ebf\u8fdb\u884c\u5168\u8840\u7ec6\u80de\u68c0\u6d4b\uff0c\u968f\u540e\u6bcf\u6708\u76d1\u6d4b\u4e00\u6b21\uff0c\u4e4b\u540e\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u671f\u95f4\u51fa\u73b0\u7684\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u53c2\u6570\u53d8\u5316\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5e38\u89c1\u7684\u5404\u7c7b\u4e0d\u826f\u53cd\u5e94\u4e3a\u8d2b\u8840\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u4e0b\u964d\u3001\u6076\u5fc3\u3001\u5455\u5410\u3001\u8179\u6cfb\u3001\u4e0a\u547c\u5438\u9053\u611f\u67d3\u3001\u75b2\u4e4f\u3001\u98df\u6b32\u4e0b\u964d\u3001\u5173\u8282\u75db\u3001\u808c\u75db\u3001\u5473\u89c9\u969c\u788d\u548c\u5934\u75db\u7b49\uff0c\u5176\u4e2d\u53d1\u751f\u7387\u6700\u9ad8\u7684\u4e0d\u826f\u53cd\u5e94\u4f9d\u6b21\u4e3a\u6076\u5fc3\u3001\u75b2\u4e4f\u548c\u8d2b\u8840\uff0c\u5927\u591a\u4e3a<span>1<\/span>\uff5e<span>2<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u7684\u8d2b\u8840\u53d1\u751f\u7387\u7ea6\u4e3a<span>20%<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>4<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\u53ef\u901a\u8fc7\u5242\u91cf\u4e2d\u65ad\u6765\u7ba1\u7406\u3002\u5f85\u75c7\u72b6\u6062\u590d\u81f3\u2264<span>1<\/span>\u7ea7\u65f6\uff0c\u91cd\u65b0\u5f00\u59cb\u539f\u5242\u91cf\u6216\u51cf\u91cf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u9700\u8981\u51cf\u91cf\uff0c\u63a8\u8350\u5242\u91cf\u51cf\u81f3<span>250mg\/<\/span>\u6b21\uff08<span>1<\/span>\u7247<span>150mg<\/span>\u7247\u5242\uff0c<span>1<\/span>\u7247<span>100mg<\/span>\u7247\u5242\uff09\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u5373\u6bcf\u5929\u603b\u5242\u91cf\u4e3a<span>500mg<\/span>\u3002\u5982\u679c\u9700\u8981\u8fdb\u4e00\u6b65\u51cf\u91cf\uff0c\u5219\u63a8\u8350\u5242\u91cf\u51cf\u81f3<span>200mg\/<\/span>\u6b21\uff08<span>2<\/span>\u7247<span>100mg<\/span>\u7247\u5242\uff09\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u5373\u6bcf\u5929\u603b\u5242\u91cf\u4e3a<span>400mg<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u63a8\u8350\u672c\u54c1\u4e0e\u5f3a\u6548\u6216\u4e2d\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\u5408\u5e76\u4f7f\u7528\uff0c\u5982\u679c\u5fc5\u987b\u5408\u5e76\u4f7f\u7528\u5f3a\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\uff0c\u63a8\u8350\u5c06\u672c\u54c1\u5242\u91cf\u51cf\u81f3<span>100mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u5982\u679c\u5fc5\u987b\u5408\u5e76\u4f7f\u7528\u4e2d\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\uff0c\u63a8\u8350\u5c06\u672c\u54c1\u5242\u91cf\u51cf\u81f3<span>150mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e8c\u3001\u5c3c\u62c9\u5e15\u5229<span> Niraparib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>100mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u9002\u7528\u4e8e\u665a\u671f\u4e0a\u76ae\u6027\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u764c\u6210\u4eba\u60a3\u8005\u5bf9\u4e00\u7ebf\u542b\u94c2\u5316\u7597\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u6216\u90e8\u5206\u7f13\u89e3\u540e\u7684\u7ef4\u6301\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u9002\u7528\u4e8e\u94c2\u654f\u611f\u7684\u590d\u53d1\u6027\u4e0a\u76ae\u6027\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u764c\u6210\u4eba\u60a3\u8005\u5728\u542b\u94c2\u5316\u7597\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u6216\u90e8\u5206\u7f13\u89e3\u540e\u7684\u7ef4\u6301\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4ecb\u7ecd\uff1a\uff08<span>1<\/span>\uff09\u5375\u5de2\u764c\u4e00\u7ebf\u7ef4\u6301\u6cbb\u7597\uff1a\u5bf9\u4e8e\u4f53\u91cd\uff1c<span>77kg<\/span>\u6216\u8005\u57fa\u7ebf\u8840\u5c0f\u677f\u8ba1\u6570\uff1c<span>150<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u7684\u60a3\u8005\uff0c\u672c\u54c1\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u5929\u4e00\u6b21\u53e3\u670d<span>200mg<\/span>\uff1b\u5bf9\u4e8e\u4f53\u91cd\u2265<span>77kg<\/span>\u4e14\u57fa\u7ebf\u8840\u5c0f\u677f\u8ba1\u6570\u2265<span>150<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u7684\u60a3\u8005\uff0c\u672c\u54c1\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u5929\u4e00\u6b21\u53e3\u670d<span>300mg<\/span>\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u4e0d\u826f\u53cd\u5e94\u3002\u60a3\u8005\u5e94\u5728\u542b\u94c2\u5316\u7597\u7ed3\u675f\u540e\u7684<span>12<\/span>\u5468\u5185\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u3002\uff08<span>2<\/span>\uff09\u590d\u53d1\u6027\u5375\u5de2\u764c\u7ef4\u6301\u6cbb\u7597\uff1a\u672c\u54c1\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u5929\u4e00\u6b21\u53e3\u670d<span>300mg<\/span>\uff0c\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u4e0d\u826f\u53cd\u5e94\u3002\u5bf9\u4e8e\u4f53\u91cd\u4f4e\u4e8e<span>58kg<\/span>\u7684\u60a3\u8005\uff0c\u53ef\u8003\u8651<span>200mg<\/span>\u7684\u8d77\u59cb\u5242\u91cf\u3002\u590d\u53d1\u6027\u5375\u5de2\u764c\u7ef4\u6301\u6cbb\u7597\u7684\u60a3\u8005\u5e94\u5728\u542b\u94c2\u5316\u7597\u7ed3\u675f\u540e\u7684<span>8<\/span>\u5468\u5185\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u3002\uff08<span>3<\/span>\uff09\u7ecf\u8fc7\u4e09\u6b21\u6216\u4e09\u6b21\u4ee5\u4e0a\u5316\u7597\u540e\u7684\u665a\u671f\u5375\u5de2\u764c\u6cbb\u7597\uff1a\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u5929\u4e00\u6b21\u53e3\u670d<span>300mg<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u6bcf\u5929\u5927\u81f4\u76f8\u540c\u65f6\u95f4\u670d\u7528\uff0c\u5e94\u6574\u7c92\u541e\u670d\uff0c\u4e0d\u5e94\u6eb6\u89e3\u6216\u6253\u5f00\u80f6\u56ca\u3002\u5728\u8fdb\u9910\u6216\u7a7a\u8179\u65f6\u5747\u53ef\u670d\u7528\u3002\u7761\u524d\u7ed9\u836f\u53ef\u80fd\u4f1a\u6709\u5229\u4e8e\u63a7\u5236\u6076\u5fc3\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u60a3\u8005\u5455\u5410\u6216\u6f0f\u670d\u4e00\u5242\u836f\u7269\uff0c\u4e0d\u5e94\u8865\u670d\uff0c\u800c\u5e94\u5728\u7b2c\u4e8c\u5929\u7684\u5e38\u89c4\u65f6\u95f4\u670d\u7528\u4e0b\u4e00\u6b21\u5904\u65b9\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u60a3\u8005\u5e94\u5728\u65e2\u5f80\u6297\u80bf\u7624\u6cbb\u7597\u5f15\u8d77\u7684\u8840\u6db2\u5b66\u6bd2\u6027\u6062\u590d\u4e4b\u540e\uff08\u57fa\u7ebf\u8840\u6db2\u5b66\u53c2\u6570\u5fc5\u987b\u7b26\u5408\u4ee5\u4e0b\u6807\u51c6\uff1a\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u6570\u2265<span>1.5<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff0c\u8840\u5c0f\u677f\u2265<span>100<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff0c\u4e14\u8840\u7ea2\u86cb\u767d\u2265<span>90g\/L<\/span>\uff09\uff0c\u624d\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u3002\u5728\u6cbb\u7597\u6700\u521d\u7684<span>12<\/span>\u4e2a\u6708\u5185\uff0c\u63a8\u8350\u7b2c\u4e00\u4e2a\u6708\u5185\u6bcf\u5468\u68c0\u6d4b\u4e00\u6b21\u5168\u8840\u7ec6\u80de\u8ba1\u6570\uff0c\u5728\u63a5\u4e0b\u6765<span>11<\/span>\u4e2a\u6708\u7684\u6cbb\u7597\u4e2d\u6bcf\u6708\u68c0\u6d4b\u4e00\u6b21\uff0c<span>1<\/span>\u5e74\u540e\u5b9a\u671f\u68c0\u6d4b\u3002\u5982\u679c\u60a3\u8005\u53d1\u751f\u91cd\u5ea6\u6301\u7eed\u6027\u8840\u6db2\u5b66\u6bd2\u6027\u53cd\u5e94\uff0c\u4e14\u5728\u6682\u505c\u7528\u836f\u540e<span>28<\/span>\u5929\u5185\u4ecd\u672a\u597d\u8f6c\uff0c\u5e94\u505c\u7528\u672c\u54c1\uff0c\u5e76\u8f6c\u8bca\u60a3\u8005\u81f3\u8840\u6db2\u79d1\uff0c\u8fdb\u884c\u8fdb\u4e00\u6b65\u68c0\u67e5\uff0c\u5305\u62ec\u9aa8\u9ad3\u5206\u6790\u548c\u8840\u6db2\u6837\u672c\u9057\u4f20\u5b66\u5206\u6790\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5e38\u89c1\u7684\u5404\u7c7b\u4e0d\u826f\u53cd\u5e94\u4e3a\u8d2b\u8840\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u5fc3\u60b8\u3001\u6076\u5fc3\u3001\u5455\u5410\u3001\u8179\u6cfb\u3001\u4fbf\u79d8\u3001\u8179\u75db<span>\/<\/span>\u8179\u80c0\u3001\u6d88\u5316\u4e0d\u826f\u3001\u53e3\u5e72\u3001\u75b2\u4e4f\u3001\u98df\u6b32\u51cf\u9000\u3001\u6ccc\u5c3f\u7cfb\u7edf\u611f\u67d3\u3001<span>AST\/ALT<\/span>\u5347\u9ad8\u3001\u5173\u8282\u75db\u3001\u808c\u75db\u3001\u5934\u75db\u3001\u5934\u6655\u3001\u5473\u89c9\u969c\u788d\u3001\u5931\u7720\u7b49\u3002\u5c3c\u62c9\u5e15\u5229\u7528\u4e8e\u4e2d\u56fd\u94c2\u654f\u611f\u590d\u53d1\u5375\u5de2\u764c\u7ef4\u6301\u6cbb\u7597\u7684<span>NORA<\/span>\u7814\u7a76\u6570\u636e\u663e\u793a\u53d1\u751f\u7387\u6700\u9ad8\u7684\u4e0d\u826f\u53cd\u5e94\u4f9d\u6b21\u4e3a\u767d\u7ec6\u80de\u8ba1\u6570\u51cf\u5c11\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\u548c\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\uff0c\u5927\u591a\u4e3a<span>1<\/span>\uff5e<span>2<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\u7684\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u53d1\u751f\u7387\u4e3a<span>11.3%<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>4<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\u53ef\u901a\u8fc7\u5242\u91cf\u4e2d\u65ad\u548c\u5bf9\u75c7\u5904\u7406\u6765\u7ba1\u7406\u3002\u5bf9\u4e8e\u975e\u8840\u6db2\u5b66\u6bd2\u6027\uff0c\u5f85\u75c7\u72b6\u6062\u590d\u81f3\u2264<span>1<\/span>\u7ea7\u65f6\uff0c\u91cd\u65b0\u5f00\u59cb\u539f\u5242\u91cf\u6216\u51cf\u91cf\u6cbb\u7597\u3002\u5bf9\u4e8e\u8840\u6db2\u5b66\u6bd2\u6027\uff0c\u5f53\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u6570\u6062\u590d\u81f3\u2265<span>1.5<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff0c\u8840\u5c0f\u677f\u6062\u590d\u81f3\u2265<span>100<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\uff0c\u4e14\u8840\u7ea2\u86cb\u767d\u6062\u590d\u81f3\u2265<span>90g\/L<\/span>\u65f6\uff0c\u91cd\u65b0\u5f00\u59cb\u539f\u5242\u91cf\u6216\u51cf\u91cf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u9700\u8981\u51cf\u91cf\uff0c\u63a8\u8350\u5242\u91cf\u51cf\u81f3<span>200mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e00\u6b21\u3002\u9700\u8981\u8fdb\u4e00\u6b65\u51cf\u91cf\uff0c\u5219\u63a8\u8350\u5242\u91cf\u51cf\u81f3<span>100mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e00\u6b21\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u901a\u8fc7\u7fa7\u9178\u916f\u9176\u8fdb\u884c\u4ee3\u8c22\uff0c\u5728\u4e0e<span>CYP<\/span>\u8bf1\u5bfc\u5242\u548c<span>CYP<\/span>\u6291\u5236\u5242\u5408\u5e76\u4f7f\u7528\u65f6\uff0c\u4e0d\u9700\u8981\u8c03\u6574\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">9.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u4e8e\u8f7b\u4e2d\u5ea6\u809d\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u4e0d\u9700\u8981\u8c03\u6574\u5242\u91cf\u3002\u5bf9\u4e8e\u91cd\u5ea6\u809d\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u5e94\u614e\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><sup><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u203b<\/span><\/sup><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">10.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5bf9\u65e2\u5f80\u5df2\u63a5\u53d7\u8fc7\u2265\u4e09\u6b21\u5316\u7597\u7684\u80bf\u7624\u540c\u6e90\u91cd\u7ec4\u4fee\u590d\u7f3a\u9677\u9633\u6027\u7684\u665a\u671f\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u764c\u6210\u4eba\u60a3\u8005\u7684\u6cbb\u7597\uff0c\u5176\u764c\u75c7\u5177\u6709\u4e0b\u8ff0\u7279\u5f81\u4e4b\u4e00\uff1a\u6709\u5bb3\u6216\u7591\u4f3c\u6709\u5bb3\u7684<span>BRCA<\/span>\u7a81\u53d8\uff0c\u6216\u57fa\u56e0\u7ec4\u4e0d\u7a33\u5b9a\u4e14\u672b\u6b21\u542b\u94c2\u5316\u7597\u5e94\u7b54\u540e\u8d85\u8fc7<span>6<\/span>\u4e2a\u6708\u8fdb\u5c55\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e09\u3001\u6c1f\u5511\u5e15\u5229<span> Fluzoparib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>50mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u94c2\u654f\u611f\u7684\u590d\u53d1\u6027\u4e0a\u76ae\u6027\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u764c\u6210\u4eba\u60a3\u8005\u5728\u542b\u94c2\u5316\u7597\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u6216\u90e8\u5206\u7f13\u89e3\u540e\u7684\u7ef4\u6301\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u65e2\u5f80\u7ecf\u8fc7\u4e8c\u7ebf\u53ca\u4ee5\u4e0a\u5316\u7597\u7684\u4f34\u6709\u80da\u7cfb<span>BRCA<\/span>\u7a81\u53d8\u7684\u94c2\u654f\u611f\u590d\u53d1\u6027\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u63a8\u8350\u5242\u91cf\u4e3a<span>150mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\uff08\u65e9\u665a\u5404\u4e00\u6b21\uff09\uff0c\u5373\u6bcf\u5929\u603b\u5242\u91cf\u4e3a<span>300mg<\/span>\u3002\u60a3\u8005\u5728\u5f00\u59cb\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u540e\uff0c\u5e94\u6301\u7eed\u6cbb\u7597\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u53d1\u751f\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u53cd\u5e94\u3002\u9488\u5bf9\u94c2\u654f\u611f\u590d\u53d1\u6027\u5375\u5de2\u764c\u7684\u7ef4\u6301\u6cbb\u7597\uff0c\u60a3\u8005\u5e94\u5728\u542b\u94c2\u5316\u7597\u7ed3\u675f\u540e\u7684<span>4<\/span>\uff5e<span>8<\/span>\u5468\u5185\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53e3\u670d\u7ed9\u836f\uff0c\u5e94\u6574\u7c92\u541e\u670d\u3002\u5728\u8fdb\u9910\u6216\u7a7a\u8179\u65f6\u5747\u53ef\u670d\u7528\uff08\u63a8\u8350\u8fdb\u9910\u540e\u670d\u7528\uff09\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u60a3\u8005\u6f0f\u670d\u4e00\u5242\u836f\u7269\uff0c\u65e0\u9700\u8865\u670d\uff0c\u4ecd\u6309\u8ba1\u5212\u65f6\u95f4\u6b63\u5e38\u670d\u7528\u4e0b\u4e00\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u60a3\u8005\u5e94\u5728\u65e2\u5f80\u6297\u80bf\u7624\u6cbb\u7597\u5f15\u8d77\u7684\u8840\u6db2\u5b66\u6bd2\u6027\u6062\u590d\u4e4b\u540e\uff08\u8840\u7ea2\u86cb\u767d\u3001\u8840\u5c0f\u677f\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u6c34\u5e73\u5e94\u6062\u590d\u81f3\u2264<span>CTCAE 1<\/span>\u7ea7\uff09\uff0c\u624d\u5f00\u59cb\u672c\u54c1\u6cbb\u7597\u3002\u5728\u6cbb\u7597\u6700\u521d\u7684<span>3<\/span>\u4e2a\u6708\u5185\uff0c\u63a8\u8350\u5728\u57fa\u7ebf\u8fdb\u884c\u5168\u8840\u7ec6\u80de\u68c0\u6d4b\uff0c\u968f\u540e\u6bcf<span>2<\/span>\u5468\u76d1\u6d4b\u4e00\u6b21\uff0c\u4e4b\u540e\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u671f\u95f4\u51fa\u73b0\u7684\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u53c2\u6570\u53d8\u5316\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u60a3\u8005\u51fa\u73b0\u91cd\u5ea6\u6216\u8f93\u8840\u4f9d\u8d56\u6027\u7684\u8840\u6db2\u5b66\u6bd2\u6027\uff0c\u5e94\u4e2d\u65ad\u6cbb\u7597\uff0c\u5e76\u4e14\u5e94\u8fdb\u884c\u76f8\u5173\u7684\u8840\u6db2\u5b66\u68c0\u6d4b\u3002\u5982\u679c\u672c\u54c1\u7ed9\u836f\u4e2d\u65ad<span>4<\/span>\u5468\u540e\u8840\u6db2\u6307\u6807\u4ecd\u5b58\u5728\u4e34\u5e8a\u5f02\u5e38\uff0c\u5219\u63a8\u8350\u9aa8\u9ad3\u5206\u6790\u548c<span>\/<\/span>\u6216\u8840\u7ec6\u80de\u9057\u4f20\u5b66\u5206\u6790\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7528\u836f\u671f\u95f4\u5e38\u89c1\u7684\u5404\u7c7b\u4e0d\u826f\u53cd\u5e94\uff08\u53d1\u751f\u7387\u2265<span>10%<\/span>\uff0c\u6309\u53d1\u751f\u7387\u9ad8\u4f4e\u6392\u5e8f\uff09\u5206\u522b\u4e3a\u8d2b\u8840\u3001\u6076\u5fc3\u3001\u767d\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u4e4f\u529b\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u5455\u5410\u3001\u98df\u6b32\u51cf\u9000\u3001\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u8840\u808c\u9150\u5347\u9ad8\u3001<span>ALT<\/span>\u5347\u9ad8\u3002\u5927\u591a\u4e3a<span>1<\/span>\uff5e<span>2<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c<span>3<\/span>\u7ea7\u53ca\u4ee5\u4e0a\u4e0d\u826f\u53cd\u5e94\uff08\u53d1\u751f\u7387\u2265<span>2%<\/span>\uff09\u5305\u62ec\uff1a\u8d2b\u8840\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u767d\u7ec6\u80de\u51cf\u5c11\u75c7\u548c\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u75c7\u3002\u591a\u6570\u4e0d\u826f\u53cd\u5e94\u901a\u8fc7\u5242\u91cf\u6682\u505c\u6216\u7ea0\u6b63\u6cbb\u7597\u5747\u80fd\u6062\u590d\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>4<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94\u53ef\u901a\u8fc7\u5242\u91cf\u4e2d\u65ad\u6765\u7ba1\u7406\u3002\u5f85\u75c7\u72b6\u6062\u590d\u81f3\u2264<span>1<\/span>\u7ea7\u65f6\uff0c\u91cd\u65b0\u5f00\u59cb\u539f\u5242\u91cf\u6216\u51cf\u91cf\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u9700\u8981\u51cf\u91cf\uff0c\u63a8\u8350\u5242\u91cf\u51cf\u81f3<span>100mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u5373\u6bcf\u5929\u603b\u5242\u91cf\u4e3a<span>200mg<\/span>\u3002\u5982\u679c\u9700\u8981\u8fdb\u4e00\u6b65\u51cf\u91cf\uff0c\u5219\u63a8\u8350\u5242\u91cf\u51cf\u81f3<span>50mg<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\/<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b21<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u5373\u6bcf\u5929\u603b\u5242\u91cf\u4e3a<span>100mg<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">8.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672c\u54c1\u6cbb\u7597\u671f\u95f4\u907f\u514d\u5408\u5e76\u4f7f\u7528<span>CYP3A4<\/span>\u5f3a\u6291\u5236\u5242\u3002\u5982\u5fc5\u987b\u4f7f\u7528\uff0c\u53ef\u4ee5\u505c\u7528\u6c1f\u5511\u5e15\u5229\uff1b\u5728\u505c\u6b62\u5408\u5e76\u4f7f\u7528<span>CYP3A4<\/span>\u5f3a\u6291\u5236\u5242\u4e14\u81f3\u8be5\u836f\u7269\u6e05\u9664<span>5<\/span>\uff5e<span>7<\/span>\u4e2a\u534a\u8870\u671f\u540e\uff0c\u53ef\u6062\u590d\u6c1f\u5511\u5e15\u5229\u81f3\u539f\u7ed9\u836f\u5242\u91cf\u548c\u9891\u7387\u3002\u5982\u4e0e<span>CYP3A4<\/span>\u4e2d\u7b49\u6291\u5236\u5242\u5408\u7528\u65f6\uff0c\u5efa\u8bae\u4e0b\u8c03\u6c1f\u5511\u5e15\u5229\u5242\u91cf\u81f3<span>50mg<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u56db\u3001\u5e15\u7c73\u5e15\u5229<span> Pamiparib<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80f6\u56ca\uff1a<span>20mg<\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9002\u5e94\u8bc1\uff1a<\/span><\/b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u7c73\u5e15\u5229\u9002\u7528\u4e8e\u65e2\u5f80\u7ecf\u8fc7\u4e8c\u7ebf\u53ca\u4ee5\u4e0a\u5316\u7597\u7684\u4f34\u6709\u80da\u7cfb<span>BRCA<\/span>\u7a81\u53d8\u7684\u590d\u53d1\u6027\u665a\u671f\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5408\u7406\u7528\u836f\u8981\u70b9\uff1a<span><\/span><\/span><\/b>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5e15\u7c73\u5e15\u5229\u63a8\u8350\u5242\u91cf\u4e3a<span>60mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u6301\u7eed\u6cbb\u7597\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u53d1\u751f\u4e0d\u53ef\u8010\u53d7\u7684\u4e0d\u826f\u53cd\u5e94\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5efa\u8bae\u60a3\u8005\u5728\u6bcf\u5929\u5927\u81f4\u76f8\u540c\u65f6\u95f4\u70b9\u53e3\u670d\u7ed9\u836f\uff0c\u672c\u54c1\u5e94\u6574\u7c92\u541e\u670d\uff0c\u4e0d\u5e94\u5480\u56bc\u3001\u538b\u788e\u3001\u6eb6\u89e3\u6216\u6253\u5f00\u80f6\u56ca\u3002\u672c\u54c1\u5728\u8fdb\u9910\u6216\u7a7a\u8179\u65f6\u5747\u53ef\u670d\u7528\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5982\u679c\u60a3\u8005\u53d1\u751f\u5455\u5410\u6216\u6f0f\u670d\u4e00\u6b21\u836f\u7269\uff0c\u4e0d\u5e94\u989d\u5916\u8865\u670d\uff0c\u5e94\u6309\u8ba1\u5212\u65f6\u95f4\u6b63\u5e38\u670d\u7528\u4e0b\u4e00\u6b21\u5904\u65b9\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u7684<span>317<\/span>\u4f8b\u60a3\u8005\u4e2d<span>[BGB-290-102<\/span>\u60a3\u8005\u4f8b\u6570\uff08<span>N<\/span>\uff09<span>=128<\/span>\u3001<span>BGB-290-AU-002<\/span>\uff08<span>N<\/span>\uff09<span>=101<\/span>\u548c<span>BGB-290-201<\/span>\uff08<span>N<\/span>\uff09<span>=88]<\/span>\uff0c\u53d1\u751f\u7387\u2265<span>10%<\/span>\u7684\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\uff1a\u8d2b\u8840\u3001\u6076\u5fc3\u3001\u767d\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u5455\u5410\u3001\u75b2\u4e4f\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3001\u98df\u6b32\u51cf\u9000\u3001\u8179\u6cfb\u3001\u8179\u75db\u3001<span>AST<\/span>\u5347\u9ad8\u3001<span>ALT<\/span>\u5347\u9ad8\u3001\u8840\u80c6\u7ea2\u7d20\u5347\u9ad8\u4ee5\u53ca\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u75c7\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e3a\u7ba1\u7406\u5e15\u7c73\u5e15\u5229\u7684\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94\uff0c\u9700\u5b9a\u671f\u68c0\u6d4b\u5168\u8840\u7ec6\u80de\u8ba1\u6570\u3002\u5efa\u8bae\u5728\u6cbb\u7597\u7684\u524d<span>3<\/span>\u4e2a\u6708\u5185\u6bcf\u5468\u68c0\u6d4b\u4e00\u6b21\uff0c\u4e4b\u540e\u5b9a\u671f\u76d1\u6d4b\u6cbb\u7597\u671f\u95f4\u51fa\u73b0\u7684\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u53c2\u6570\u53d8\u5316\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">6.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e3a\u7ba1\u7406\u836f\u7269\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\u8003\u8651\u6682\u505c\u6cbb\u7597\u6216\u51cf\u91cf\u3002\u7b2c\u4e00\u6b21\u63a8\u8350\u5242\u91cf\u51cf\u81f3<span>40mg\/<\/span>\u6b21\uff0c\u6bcf\u5929\u4e24\u6b21\u3002\u5982\u679c\u9700\u8981\u8fdb\u4e00\u6b65\u51cf\u91cf\uff0c\u5219\u63a8\u8350\u5242\u91cf\u51cf\u81f3<span>20mg<\/span><\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\/<\/span><span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b21<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u6bcf\u5929\u4e24\u6b21\u3002\u9488\u5bf9\u975e\u8840\u6db2\u5b66\u548c\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94\u7684\u5242\u91cf\u8c03\u6574\u8981\u6c42\u53c2\u89c1\u8868<span>10<\/span>\u548c\u8868<span>11<\/span>\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8868<span>10<\/span>&emsp;\u9488\u5bf9\u975e\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94\u7684\u5242\u91cf\u8c03\u6574<span><\/span><\/span><\/b>\n<\/p>\n<table class=\"MsoTableGrid\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\" style=\"border-collapse:collapse;border:none;\">\n<tbody>\n<tr>\n<td width=\"568\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u826f\u53cd\u5e94<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"568\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u8c03\u6574<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"568\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">CTCAE<sup>*<\/sup>3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\u975e\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94\uff0c\u4e0d\u80fd\u901a\u8fc7\u9884\u9632\u6cbb\u7597\uff0c\u6216\u7ecf\u8fc7\u6cbb\u7597\u4e0d\u826f\u53cd\u5e94\u4ecd\u6301\u7eed\u5b58\u5728<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"568\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u670d\u7528\u672c\u54c1\u4e0d\u8d85\u8fc7<span>28<\/span>\u5929\u76f4\u81f3\u4e0d\u826f\u53cd\u5e94\u7f13\u89e3<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728\u4e0b\u8c03\u7684\u5242\u91cf\u4e0b\u6062\u590d\u672c\u54c1\u6cbb\u7597<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"568\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u540e\u6301\u7eed\u5b58\u5728\u7684<span>CTCAE 4<\/span>\u7ea7\u975e\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"568\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<sup><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">*<\/span><\/sup><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6ce8\uff1a\u6309\u7167\u7f8e\u56fd\u56fd\u7acb\u764c\u75c7\u7814\u7a76\u6240\u7684\u4e0d\u826f\u4e8b\u4ef6\u901a\u7528\u672f\u8bed\u8bc4\u4f30\u6807\u51c6<span>4.03<\/span>\u7248\uff08<span>NCI-CTCAEv4.03<\/span>\uff09\u786e\u5b9a\u4e25\u91cd\u7a0b\u5ea6\u5206\u7ea7\u3002<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormalCxSpMiddle\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8868<span>11<\/span>&emsp;\u9488\u5bf9\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94\u7684\u5242\u91cf\u8c03\u6574<span><\/span><\/span><\/b>\n<\/p>\n<table class=\"MsoTableGrid\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\" style=\"border-collapse:collapse;border:none;\">\n<tbody>\n<tr>\n<td width=\"279\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e0d\u826f\u53cd\u5e94<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"857\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5242\u91cf\u8c03\u6574<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"279\" rowspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8d2b\u8840<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff08\u8840\u7ea2\u86cb\u767d\uff1c<span>90g\/L<\/span>\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"857\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9996\u6b21\u53d1\u751f\uff1a<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\u5e76\u9075\u533b\u5631\u6cbb\u7597\u76f4\u81f3\u8840\u7ea2\u86cb\u767d\u6062\u590d\u81f3<\/span><span style=\"font-size:14pt;line-height:150%;\"> <\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u2265<span>90<\/span><\/span><span style=\"font-size:14pt;line-height:150%;\"> <\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">g\/L<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u6c34\u5e73\u4ee5<span>40mg<\/span>\u6bcf\u5929\u4e24\u6b21\u7ed9\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"857\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u518d\u6b21\u53d1\u751f\uff1a<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u57fa\u4e8e\u4e34\u5e8a\u8bc4\u4f30\u7ed9\u4e88\u9002\u5f53\u7684\u652f\u6301\u6027\u6cbb\u7597\u5e76\u7ee7\u7eed\u4ee5<span>40mg<\/span>\u6bcf\u5929\u4e24\u6b21\u7ed9\u836f\uff0c\u6216\u8005<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\u5e76\u9075\u533b\u5631\u6cbb\u7597\u76f4\u81f3\u8840\u7ea2\u86cb\u767d\u6062\u590d\u81f3\u2265<span>90g\/L<\/span>\uff0c\u4ee5<span>40mg<\/span>\u6bcf\u5929\u4e24\u6b21\u7ee7\u7eed\u7ed9\u836f\uff0c\u6216\u8005<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\u5e76\u9075\u533b\u5631\u6cbb\u7597\u76f4\u81f3\u8840\u7ea2\u86cb\u767d\u6062\u590d\u81f3\u2265<\/span><span style=\"font-size:14pt;line-height:150%;\"> <\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">90g\/L<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff0c\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u6c34\u5e73\u4ee5<span>20mg<\/span>\u6bcf\u5929\u4e24\u6b21\u7ed9\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u82e5\u8d2b\u8840\u5371\u53ca\u751f\u547d\uff0c\u9700\u7d27\u6025\u6cbb\u7597\uff1a<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\u5e76\u9075\u533b\u5631\u6cbb\u7597\u76f4\u81f3\u8840\u7ea2\u86cb\u767d\u6062\u590d\u81f3\u2265<span>90g\/L<\/span>\uff0c\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u6c34\u5e73\u4ee5<span>20mg<\/span>\u6bcf\u5929\u4e24\u6b21\u7ed9\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5728<span>20mg<\/span>\u6bcf\u5929\u4e24\u6b21\u5242\u91cf\u6c34\u5e73\u518d\u6b21\u51fa\u73b0\u8d2b\u8840\u5371\u53ca\u751f\u547d\uff0c\u4e14\u8d2b\u8840\u4e0d\u662f\u7531\u4e8e\u5176\u4ed6\u5e72\u6270\u4e8b\u4ef6\uff08\u5982\u80c3\u80a0\u9053\u51fa\u8840\uff09\u5f15\u8d77\uff0c\u5e94\u505c\u7528\u672c\u54c1<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"279\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11<span>[<\/span>\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u8ba1\u6570\uff08<span>ANC<\/span>\uff09\uff1c<span>1<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u6216\u53d1\u70ed\u6027\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7<span>]<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"857\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\uff0c\u76f4\u81f3\u6062\u590d\u81f3<span>ANC<\/span>\u2265<\/span><span style=\"font-size:14pt;line-height:150%;\"> <\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1.5\u00d710<sup>9<\/sup>\/L<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6216\u53d1\u70ed\u6027\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u7f13\u89e3\uff0c\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u6c34\u5e73\u7ed9\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"279\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8840\u5c0f\u677f\u51cf\u5c11<span>[<\/span>\u8840\u5c0f\u677f\u8ba1\u6570\uff08<span>PLT<\/span>\uff09\uff1c<span>50<\/span>\u00d7<span>10<sup>9<\/sup>\/L]<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"857\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\uff0c\u76f4\u5230\u6062\u590d\u81f3<span>PLT<\/span>\u2265<span>75<\/span>\u00d7<span>10<sup>9<\/sup>\/L<\/span>\u6216\u57fa\u7ebf\u6c34\u5e73\uff0c\u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u6c34\u5e73\u7ed9\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormalCxSpMiddle\" style=\"text-indent:28.0pt;\">\n\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">7.<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5141\u8bb8\u5408\u5e76\u4f7f\u7528\u5f3a\u6548<span>\/<\/span>\u4e2d\u6548<span>\/<\/span>\u8f7b\u6548<span>CYP3A<\/span>\u6291\u5236\u5242\uff0c\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\">\u9644\u8868<span><\/span><\/span>\n<\/p>\n<p class=\"MsoNormal\" style=\"margin-left:24.0pt;text-indent:119.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9644\u8868<span>1 <\/span><\/span><\/b><b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u548c<\/span><\/b><b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u8c03\u6574\u65b9\u6848<span><\/span><\/span><\/b>\n<\/p>\n<table class=\"MsoNormalTable\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"1134\" style=\"border-collapse:collapse;border:none;\">\n<tbody>\n<tr>\n<td width=\"174\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e25\u91cd\u7a0b\u5ea6<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u8c03\u6574<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"174\" rowspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7<sup><span><\/span><\/sup><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7528\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"174\" rowspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80ba\u708e<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\uff0c\u76f4\u81f3\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u81f3<span>0<\/span>\uff5e<span>1<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>4<\/span>\u7ea7\u6216\u590d\u53d1\u6027<span>2<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"174\" rowspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8179\u6cfb\u53ca\u7ed3\u80a0\u708e<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\u6216<span>3<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\uff0c\u76f4\u81f3\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u81f3<span>0<\/span>\uff5e<span>1<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"174\" rowspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u809d\u708e<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\uff0c\u5929\u95e8\u51ac\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08<span>AST<\/span>\uff09\u6216\u4e19\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08<span>ALT<\/span>\uff09\u5728<span>3<\/span>\uff5e<span>5<\/span>\u500d\u6b63\u5e38\u503c\u4e0a\u9650\uff08<span>ULN<\/span>\uff09\u6216\u603b\u80c6\u7ea2\u7d20\uff08<span>TBIL<\/span>\uff09\u5728<span>1.5<\/span>\uff5e<span>3<\/span>\u500d<span>ULN<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\uff0c\u76f4\u81f3\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u81f3<span>0<\/span>\uff5e<span>1<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>4<\/span>\u7ea7\uff0c<span>AST<\/span>\u6216<span>ALT<\/span>\uff1e<span>5<\/span>\u500d<span>ULN<\/span>\uff0c\u6216<span>TBIL<\/span>\uff1e<span>3<\/span>\u500d<span>ULN<\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"174\" rowspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u80be\u708e<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>3<\/span>\u7ea7\u8840\u808c\u9150\u5347\u9ad8<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\uff0c\u76f4\u81f3\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u81f3<span>0<\/span>\uff5e<span>1<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\u8840\u808c\u9150\u5347\u9ad8<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"174\" rowspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5185\u5206\u6ccc\u75be\u75c5<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u75c7\u72b6\u6027<span>2<\/span>\uff5e<span>3<\/span>\u7ea7\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\uff0c<span>2<\/span>\uff5e<span>3<\/span>\u7ea7\u7532\u72b6\u817a\u529f\u80fd\u4ea2\u8fdb\u3001<span>2<\/span>\uff5e<span>3<\/span>\u7ea7\u5782\u4f53\u708e\u3001<span>2<\/span>\u7ea7\u80be\u4e0a\u817a\u529f\u80fd\u4e0d\u5168<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\u9ad8\u8840\u7cd6\u75c7\u6216<span>1<\/span>\u578b\u7cd6\u5c3f\u75c5<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\uff0c\u76f4\u81f3\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u81f3<span>0<\/span>\uff5e<span>1<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\u7532\u72b6\u817a\u529f\u80fd\u4ea2\u8fdb<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\u5782\u4f53\u708e<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>4<\/span>\u7ea7\u80be\u4e0a\u817a\u529f\u80fd\u4e0d\u5168<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\u9ad8\u8840\u7cd6\u75c7\u6216<span>1<\/span>\u578b\u7cd6\u5c3f\u75c5<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"174\" rowspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u76ae\u80a4\u4e0d\u826f\u53cd\u5e94<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\uff0c\u76f4\u81f3\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u81f3<span>0<\/span>\uff5e<span>1<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\uff0c<span>Stevens-Johnson<\/span>\u7efc\u5408\u5f81\u6216\u4e2d\u6bd2\u6027\u8868\u76ae\u574f\u6b7b\u677e\u89e3\u75c7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"174\" rowspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8840\u5c0f\u677f\u51cf\u5c11\u75c7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\uff0c\u76f4\u81f3\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u81f3<span>0<\/span>\uff5e<span>1<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"174\" rowspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5176\u4ed6\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>4<\/span>\u7ea7\u8840\u6dc0\u7c89\u9176\u5347\u9ad8\u6216\u8102\u80aa\u9176\u5347\u9ad8<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>3<\/span>\u7ea7\u80f0\u817a\u708e<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\u5fc3\u808c\u708e<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>3<\/span>\u7ea7\u9996\u6b21\u53d1\u751f\u7684\u5176\u4ed6\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7ed9\u836f\uff0c\u76f4\u81f3\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u81f3<span>0<\/span>\uff5e<span>1<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\u80f0\u817a\u708e\u6216\u4efb\u4f55\u7ea7\u522b\u7684\u590d\u53d1\u6027\u80f0\u817a\u708e<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>4<\/span>\u7ea7\u5fc3\u808c\u708e<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>4<\/span>\u7ea7\u8111\u708e<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7\u9996\u6b21\u53d1\u751f\u7684\u5176\u4ed6\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"174\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u590d\u53d1\u6216\u6301\u7eed\u7684\u4e0d\u826f\u53cd\u5e94<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u590d\u53d1\u6027<span>3<\/span>\uff5e<span>4<\/span>\u7ea7\uff08\u9664\u5916\u5185\u5206\u6ccc\u75be\u75c5\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672b\u6b21\u7ed9\u836f\u540e<span>12<\/span>\u5468\u5185<span>2<\/span>\uff5e<span>3<\/span>\u7ea7\u4e0d\u826f\u53cd\u5e94<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672a\u6539\u5584\u5230<span>0<\/span>\uff5e<span>1<\/span>\u7ea7\uff08\u9664\u5916\u5185\u5206\u6ccc\u75be\u75c5\uff09<span><\/span><\/span>\n\t\t\t\t<\/p>\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u672b\u6b21\u7ed9\u836f\u540e<span>12<\/span>\u5468\u5185\u7cd6\u76ae\u8d28\u6fc0\u7d20\u672a\u80fd\u964d\u81f3\u2264<span>10mg\/d<\/span>\u7684\u5f3a\u7684\u677e\u7b49\u6548\u5242\u91cf<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"174\" rowspan=\"2\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u8f93\u6db2\u53cd\u5e94<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u964d\u4f4e\u6ef4\u901f\u6216\u6682\u505c\u7ed9\u836f\uff0c\u5f53\u75c7\u72b6\u7f13\u89e3\u540e\u53ef\u8003\u8651\u6062\u590d\u7528\u836f\u5e76\u5bc6\u5207\u89c2\u5bdf<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"605\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\uff5e<span>4<\/span>\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"355\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p><b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\"><br \/>\n<\/span><\/b> <\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<b><span style=\"font-size:14pt;font-family:\u7b49\u7ebf;\"><\/span><\/b>\n<\/p>\n<p class=\"MsoNormal\" align=\"center\" style=\"text-align:center;text-indent:28.0pt;\">\n\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u9644\u8868<span>2 <\/span>\u53cd\u5e94\u6027\u6bdb\u7ec6\u8840\u7ba1\u589e\u751f\u75c7\u5206\u7ea7\u6807\u51c6\u548c\u6cbb\u7597\u5efa\u8bae<span><\/span><\/span><\/b>\n<\/p>\n<table class=\"MsoNormalTable\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"1136\" style=\"border-collapse:collapse;border:none;\">\n<tbody>\n<tr>\n<td width=\"128\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5206\u7ea7<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"359\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u4e34\u5e8a\u8868\u73b0<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"649\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<b><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6cbb\u7597\u5efa\u8bae<span><\/span><\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"128\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">1<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"359\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5355\u4e2a\u6700\u5927\u76f4\u5f84<span>\u226410mm<\/span>\uff0c\u4f34\u6216\u4e0d\u4f34\u7834\u6e83\u51fa\u8840<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"649\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ee7\u7eed\u7528\u836f\uff0c\u6613\u6469\u64e6\u90e8\u4f4d\u53ef\u7528\u7eb1\u5e03\u4fdd\u62a4\uff0c\u907f\u514d\u51fa\u8840\u3002\u7834\u6e83\u51fa\u8840\u8005\u53ef\u91c7\u7528\u5c40\u90e8\u538b\u8feb\u6b62\u8840\u6cbb\u7597<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"128\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">2<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"359\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5355\u4e2a\u6700\u5927\u76f4\u5f84\uff1e<span>10mm<\/span>\uff0c\u4f34\u6216\u4e0d\u4f34\u7834\u6e83\u51fa\u8840<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"649\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ee7\u7eed\u7528\u836f\uff0c\u6613\u6469\u64e6\u90e8\u4f4d\u53ef\u7528\u7eb1\u5e03\u4fdd\u62a4\uff0c\u907f\u514d\u51fa\u8840\u3002\u7834\u6e83\u51fa\u8840\u8005\u53ef\u5c40\u90e8\u538b\u8feb\u6b62\u8840\uff0c\u6216\u91c7\u53d6\u5c40\u90e8\u6cbb\u7597\u63aa\u65bd\uff0c\u5982\u6fc0\u5149\u6216\u624b\u672f\u5207\u9664\u7b49\u3002\u907f\u514d\u7834\u6e83\u5904\u611f\u67d3<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"128\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">3<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"359\" valign=\"top\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u5448\u6cdb\u53d1\u6027\uff0c\u53ef\u4ee5\u5e76\u53d1\u76ae\u80a4\u611f\u67d3\uff0c\u53ef\u80fd\u9700\u8981\u4f4f\u9662\u6cbb\u7597<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"649\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6682\u505c\u7528\u836f\uff0c\u5f85\u6062\u590d\u81f3<span>\u22641<\/span>\u7ea7\u540e\u6062\u590d\u7ed9\u836f\uff0c\u6613\u6469\u64e6\u90e8\u4f4d\u53ef\u7528\u7eb1\u5e03\u4fdd\u62a4\uff0c\u907f\u514d\u51fa\u8840\u3002\u7834\u6e83\u51fa\u8840\u8005\u53ef\u5c40\u90e8\u538b\u8feb\u6b62\u8840\uff0c\u6216\u91c7\u53d6\u5c40\u90e8\u6cbb\u7597\u63aa\u65bd\u5982\u6fc0\u5149\u6216\u624b\u672f\u5207\u9664\u7b49\uff0c\u5e76\u53d1\u611f\u67d3\u8005\u7ed9\u4e88\u6297\u611f\u67d3\u6cbb\u7597<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"128\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">4<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"359\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u591a\u53d1\u548c\u6cdb\u53d1\uff0c\u5a01\u80c1\u751f\u547d<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"649\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6c38\u4e45\u505c\u836f<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"128\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">5<\/span><span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u7ea7<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"359\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\">\u6b7b\u4ea1<span><\/span><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<td width=\"649\" style=\"border:solid windowtext 1.0pt;\">\n<p class=\"MsoNormal\" align=\"left\">\n\t\t\t\t\t<span style=\"font-size:14pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\">\n\t<span style=\"font-size:14.0pt;line-height:150%;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;color:#333333;\"><\/span>\n<\/p>\n<p class=\"MsoNormal\" align=\"left\">\n\t<span style=\"font-size:14.0pt;font-family:\u7b49\u7ebf;\"><\/span>\n<\/p>\n<p>\n\t\n<\/p>\n<p class=\"MsoNormal\" align=\"right\" style=\"text-align:right;text-indent:21.0pt;\">\n\t\n<\/p>\n<p class=\"MsoNormal\" 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